Transfer learning is a machine learning technique designed to improve generalization performance by using pre-trained parameters obtained from other learning tasks. For image recognition tasks, many previous studies have reported that, when transfer learning is applied to deep neural networks, performance improves, despite having limited training data. This paper proposes a two-stage feature transfer learning method focusing on the recognition of textural medical images. During the proposed method, a model is successively trained with massive amounts of natural images, some textural images, and the target images. We applied this method to the classification task of textural X-ray computed tomography images of diffuse lung diseases. In our experiment, the two-stage feature transfer achieves the best performance compared to a from-scratch learning and a conventional single-stage feature transfer. We also investigated the robustness of the target dataset, based on size. Two-stage feature transfer shows better robustness than the other two learning methods. Moreover, we analyzed the feature representations obtained from DLDs imagery inputs for each feature transfer models using a visualization method. We showed that the two-stage feature transfer obtains both edge and textural features of DLDs, which does not occur in conventional single-stage feature transfer models.
@cite_11 @cite_9 applied a feature transfer to the classification of DLDs and used conventional single-staged feature transfer, which uses a natural image dataset. They reported that feature tranfer improves the classification performance over learning from scratch. However, the appropriateness of the source domain was not discussed, despite noting that the targets were textural. @cite_17 proposed an ensemble method that used multiple models trained with different domains for lung disorder classification. The term, transfer learning,'' references fine-tuning. The essence of this method entails ensemble modeling, rather than an actual transfer process. A notable study of transfer learning in the field of medical image analysis, @cite_14 , systematically surveyed and analyzed the effects of transfer learning for various types of medical images, including textural images. They compared transfer learning from natural images and several modern parameter initialization methods in various medical image classification tasks, which had limited amounts of training data. They concluded that transfer learning from natural images to medical images is possible and meaningful, despite the large difference between the source and target domains. Nonetheless, the reason transfer learning works in DCNNs is still not fully understood.
@cite_9 @cite_14 @cite_17 @cite_11
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Convolutional networks (ConvNets) have achieved great successes in various challenging vision tasks. However, the performance of ConvNets would degrade when encountering the domain shift. The domain adaptation is more significant while challenging in the field of biomedical image analysis, where cross-modality data have largely different distributions. Given that annotating the medical data is especially expensive, the supervised transfer learning approaches are not quite optimal. In this paper, we propose an unsupervised domain adaptation framework with adversarial learning for cross-modality biomedical image segmentations. Specifically, our model is based on a dilated fully convolutional network for pixel-wise prediction. Moreover, we build a plug-and-play domain adaptation module (DAM) to map the target input to features which are aligned with source domain feature space. A domain critic module (DCM) is set up for discriminating the feature space of both domains. We optimize the DAM and DCM via an adversarial loss without using any target domain label. Our proposed method is validated by adapting a ConvNet trained with MRI images to unpaired CT data for cardiac structures segmentations, and achieved very promising results. In spite of the compelling achievements that deep neural networks (DNNs) have made in medical image computing, these deep models often suffer from degraded performance when being applied to new test datasets with domain shift. In this paper, we present a novel unsupervised domain adaptation approach for segmentation tasks by designing semantic-aware generative adversarial networks (GANs). Specifically, we transform the test image into the appearance of source domain, with the semantic structural information being well preserved, which is achieved by imposing a nested adversarial learning in semantic label space. In this way, the segmentation DNN learned from the source domain is able to be directly generalized to the transformed test image, eliminating the need of training a new model for every new target dataset. Our domain adaptation procedure is unsupervised, without using any target domain labels. The adversarial learning of our network is guided by a GAN loss for mapping data distributions, a cycle-consistency loss for retaining pixel-level content, and a semantic-aware loss for enhancing structural information. We validated our method on two different chest X-ray public datasets for left right lung segmentation. Experimental results show that the segmentation performance of our unsupervised approach is highly competitive with the upper bound of supervised transfer learning. Remarkable progress has been made in image recognition, primarily due to the availability of large-scale annotated datasets and deep convolutional neural networks (CNNs). CNNs enable learning data-driven, highly representative, hierarchical image features from sufficient training data. However, obtaining datasets as comprehensively annotated as ImageNet in the medical imaging domain remains a challenge. There are currently three major techniques that successfully employ CNNs to medical image classification: training the CNN from scratch, using off-the-shelf pre-trained CNN features, and conducting unsupervised CNN pre-training with supervised fine-tuning. Another effective method is transfer learning, i.e., fine-tuning CNN models pre-trained from natural image dataset to medical image tasks. In this paper, we exploit three important, but previously understudied factors of employing deep convolutional neural networks to computer-aided detection problems. We first explore and evaluate different CNN architectures. The studied models contain 5 thousand to 160 million parameters, and vary in numbers of layers. We then evaluate the influence of dataset scale and spatial image context on performance. Finally, we examine when and why transfer learning from pre-trained ImageNet (via fine-tuning) can be useful. We study two specific computer-aided detection (CADe) problems, namely thoraco-abdominal lymph node (LN) detection and interstitial lung disease (ILD) classification. We achieve the state-of-the-art performance on the mediastinal LN detection, and report the first five-fold cross-validation classification results on predicting axial CT slices with ILD categories. Our extensive empirical evaluation, CNN model analysis and valuable insights can be extended to the design of high performance CAD systems for other medical imaging tasks. One of the serious challenges in computer vision and image classification is learning an accurate classifier for a new unlabeled image dataset, considering that there is no available labeled training data. Transfer learning and domain adaptation are two outstanding solutions that tackle this challenge by employing available datasets, even with significant difference in distribution and properties, and transfer the knowledge from a related domain to the target domain. The main difference between these two solutions is their primary assumption about change in marginal and conditional distributions where transfer learning emphasizes on problems with same marginal distribution and different conditional distribution, and domain adaptation deals with opposite conditions. Most prior works have exploited these two learning strategies separately for domain shift problem where training and test sets are drawn from different distributions. In this paper, we exploit joint transfer learning and domain adaptation to cope with domain shift problem in which the distribution difference is significantly large, particularly vision datasets. We therefore put forward a novel transfer learning and domain adaptation approach, referred to as visual domain adaptation (VDA). Specifically, VDA reduces the joint marginal and conditional distributions across domains in an unsupervised manner where no label is available in test set. Moreover, VDA constructs condensed domain invariant clusters in the embedding representation to separate various classes alongside the domain transfer. In this work, we employ pseudo target labels refinement to iteratively converge to final solution. Employing an iterative procedure along with a novel optimization problem creates a robust and effective representation for adaptation across domains. Extensive experiments on 16 real vision datasets with different difficulties verify that VDA can significantly outperform state-of-the-art methods in image classification problem.