Our aging population increasingly suffers from multiple chronic diseases simultaneously, necessitating the comprehensive treatment of these conditions. Finding the optimal set of drugs for a combinatorial set of diseases is a combinatorial pattern exploration problem. Association rule mining is a popular tool for such problems, but the requirement of health care for finding causal, rather than associative, patterns renders association rule mining unsuitable. To address this issue, we propose a novel framework based on the Rubin-Neyman causal model for extracting causal rules from observational data, correcting for a number of common biases. Specifically, given a set of interventions and a set of items that define subpopulations (e.g., diseases), we wish to find all subpopulations in which effective intervention combinations exist and in each such subpopulation, we wish to find all intervention combinations such that dropping any intervention from this combination will reduce the efficacy of the treatment. A key aspect of our framework is the concept of closed intervention sets which extend the concept of quantifying the effect of a single intervention to a set of concurrent interventions. We also evaluated our causal rule mining framework on the Electronic Health Records (EHR) data of a large cohort of patients from Mayo Clinic and showed that the patterns we extracted are sufficiently rich to explain the controversial findings in the medical literature regarding the effect of a class of cholesterol drugs on Type-II Diabetes Mellitus (T2DM).
Applications of causal modeling is not exclusive to social and life sciences. In data mining, @cite_22 investigated the causal effect of new features on click through rates and @cite_8 used doubly robust estimation techniquest to determine the efficacy of display advertisements.
@cite_22 @cite_8
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Mining for association rules in market basket data has proved a fruitful area of research. Measures such as conditional probability (confidence) and correlation have been used to infer rules of the form “the existence of item A implies the existence of item B.” However, such rules indicate only a statistical relationship between A and B. They do not specify the nature of the relationship: whether the presence of A causes the presence of B, or the converse, or some other attribute or phenomenon causes both to appear together. In applications, knowing such causal relationships is extremely useful for enhancing understanding and effecting change. While distinguishing causality from correlation is a truly difficult problem, recent work in statistics and Bayesian learning provide some avenues of attack. In these fields, the goal has generally been to learn complete causal models, which are essentially impossible to learn in large-scale data mining applications with a large number of variables. In this paper, we consider the problem of determining casual relationships, instead of mere associations, when mining market basket data. We identify some problems with the direct application of Bayesian learning ideas to mining large databases, concerning both the scalability of algorithms and the appropriateness of the statistical techniques, and introduce some initial ideas for dealing with these problems. We present experimental results from applying our algorithms on several large, real-world data sets. The results indicate that the approach proposed here is both computationally feasible and successful in identifying interesting causal structures. An interesting outcome is that it is perhaps easier to infer the lack of causality than to infer causality, information that is useful in preventing erroneous decision making. An important problem in econometrics and marketing is to infer the causal impact that a designed market intervention has exerted on an outcome metric over time. In order to allocate a given budget optimally, for example, an advertiser must determine the incremental contributions that dierent advertising campaigns have made to web searches, product installs, or sales. This paper proposes to infer causal impact on the basis of a diusion-regressi on state-space model that predicts the counterfactual market response that would have occurred had no intervention taken place. In con- trast to classical dierence-in-dier ences schemes, state-space models make it possible to (i) infer the temporal evolution of attributable impact, (ii) incorporate empirical priors on the parameters in a fully Bayesian treatment, and (iii) exibly accommodate multiple sources of variation, including the time-varying inuence of contemporane- ous covariates, i.e., synthetic controls. Using a Markov chain Monte Carlo algorithm for posterior inference, we illustrate the statistical properties of our approach on synthetic data. We then demonstrate its practical utility by evaluating the eect of an online advertising campaign on search-related site visits. We discuss the strengths and limitations of our approach in improving the accuracy of causal at- tribution, power analyses, and principled budget allocation. In this paper, we develop an experimental analysis to estimate the causal effect of online marketing campaigns as a whole, and not just the media ad design. We analyze the causal effects on user conversion probability. We run experiments based on A B testing to perform this evaluation. We also estimate the causal effect of the media ad design given this randomization approach. We discuss the framework of a marketing campaign in the context of targeted display advertising, and incorporate the main elements of this framework in the evaluation. We consider budget constraints, the auction process, and the targeting engine in the analysis and the experimental set up. For the effects of this evaluation, we assume the targeting engine to be a black box that incorporates the impression delivery policy, the budget constraints, and the bidding process. Our method to disaggregate the campaign causal analysis is inspired on randomized experiments with imperfect compliance and the intention-to-treat (ITT) analysis. In this framework, individuals assigned randomly to the study group might refuse to take the treatment. For estimation, we present a Bayesian approach and provide credible intervals for the causal estimates. We analyze the effects of 2 independent campaigns for different products from the Advertising.com ad network for 20M+ users each campaign. Randomised controlled trials (RCTs) are the most effective approach to causal discovery, but in many circumstances it is impossible to conduct RCTs. Therefore, observational studies based on passively observed data are widely accepted as an alternative to RCTs. However, in observational studies, prior knowledge is required to generate the hypotheses about the cause-effect relationships to be tested, and hence they can only be applied to problems with available domain knowledge and a handful of variables. In practice, many datasets are of high dimensionality, which leaves observational studies out of the opportunities for causal discovery from such a wealth of data sources. In another direction, many efficient data mining methods have been developed to identify associations among variables in large datasets. The problem is that causal relationships imply associations, but the reverse is not always true. However, we can see the synergy between the two paradigms here. Specifically, association rule mining can be used to deal with the high-dimensionality problem, whereas observational studies can be utilised to eliminate noncausal associations. In this article, we propose the concept of causal rules (CRs) and develop an algorithm for mining CRs in large datasets. We use the idea of retrospective cohort studies to detect CRs based on the results of association rule mining. Experiments with both synthetic and real-world datasets have demonstrated the effectiveness and efficiency of CR mining. In comparison with the commonly used causal discovery methods, the proposed approach generally is faster and has better or competitive performance in finding correct or sensible causes. It is also capable of finding a cause consisting of multiple variables—a feature that other causal discovery methods do not possess.