Age-Related Macular Degeneration (AMD) is an asymptomatic retinal disease which may result in loss of vision. There is limited access to high-quality relevant retinal images and poor understanding of the features defining sub-classes of this disease. Motivated by recent advances in machine learning we specifically explore the potential of generative modeling, using Generative Adversarial Networks (GANs) and style transferring, to facilitate clinical diagnosis and disease understanding by feature extraction. We design an analytic pipeline which first generates synthetic retinal images from clinical images; a subsequent verification step is applied. In the synthesizing step we merge GANs (DCGANs and WGANs architectures) and style transferring for the image generation, whereas the verified step controls the accuracy of the generated images. We find that the generated images contain sufficient pathological details to facilitate ophthalmologists' task of disease classification and in discovery of disease relevant features. In particular, our system predicts the drusen and geographic atrophy sub-classes of AMD. Furthermore, the performance using CFP images for GANs outperforms the classification based on using only the original clinical dataset. Our results are evaluated using existing classifier of retinal diseases and class activated maps, supporting the predictive power of the synthetic images and their utility for feature extraction. Our code examples are available online.
Yet, a major issue has been the stability and convergence of training a GAN. Recent work @cite_19 demonstrated improved stability when using a Kantorovich-Rubinstein metric, which we have adopted in our training of the GAN for retinal images. Rapid advances have demonstrated that GANs generate realistic images, with a rich number of features. For example, GANs have been successfully applied for face generation @cite_5 , indoor scene reconstruction @cite_1 and person re-identification @cite_11 . Here we benefit from recent progress with GANs to generate new synthetic retinal disease images using both Deep Convolutional Generative Adversarial Networks (DCGANs) @cite_18 and Wasserstein GANs (WGANs) @cite_19 . These architectures utilize a convolutional decoder, and DCGAN enables the employment of large GANs using Convolutional Neural Networks (CNNs), resulting in stable training across various datasets. Finally, our use of WGANs improves the stability of learning,thereby avoiding known challenges such as model collapse @cite_19 .
@cite_18 @cite_1 @cite_19 @cite_5 @cite_11
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Generative Adversarial Networks (GANs) excel at creating realistic images with complex models for which maximum likelihood is infeasible. However, the convergence of GAN training has still not been proved. We propose a two time-scale update rule (TTUR) for training GANs with stochastic gradient descent on arbitrary GAN loss functions. TTUR has an individual learning rate for both the discriminator and the generator. Using the theory of stochastic approximation, we prove that the TTUR converges under mild assumptions to a stationary local Nash equilibrium. The convergence carries over to the popular Adam optimization, for which we prove that it follows the dynamics of a heavy ball with friction and thus prefers flat minima in the objective landscape. For the evaluation of the performance of GANs at image generation, we introduce the "Frechet Inception Distance" (FID) which captures the similarity of generated images to real ones better than the Inception Score. In experiments, TTUR improves learning for DCGANs and Improved Wasserstein GANs (WGAN-GP) outperforming conventional GAN training on CelebA, CIFAR-10, SVHN, LSUN Bedrooms, and the One Billion Word Benchmark. Generative Adversarial Networks (GANs) excel at creating realistic images with complex models for which maximum likelihood is infeasible. However, the convergence of GAN training has still not been proved. We propose a two time-scale update rule (TTUR) for training GANs with stochastic gradient descent on arbitrary GAN loss functions. TTUR has an individual learning rate for both the discriminator and the generator. Using the theory of stochastic approximation, we prove that the TTUR converges under mild assumptions to a stationary local Nash equilibrium. The convergence carries over to the popular Adam optimization, for which we prove that it follows the dynamics of a heavy ball with friction and thus prefers flat minima in the objective landscape. For the evaluation of the performance of GANs at image generation, we introduce the Frechet Inception Distance'' (FID) which captures the similarity of generated images to real ones better than the Inception Score. In experiments, TTUR improves learning for DCGANs and Improved Wasserstein GANs (WGAN-GP) outperforming conventional GAN training on CelebA, CIFAR-10, SVHN, LSUN Bedrooms, and the One Billion Word Benchmark. The main contribution of this paper is a simple semi-supervised pipeline that only uses the original training set without collecting extra data. It is challenging in 1) how to obtain more training data only from the training set and 2) how to use the newly generated data. In this work, the generative adversarial network (GAN) is used to generate unlabeled samples. We propose the label smoothing regularization for outliers (LSRO). This method assigns a uniform label distribution to the unlabeled images, which regularizes the supervised model and improves the baseline. We verify the proposed method on a practical problem: person re-identification (re-ID). This task aims to retrieve a query person from other cameras. We adopt the deep convolutional generative adversarial network (DCGAN) for sample generation, and a baseline convolutional neural network (CNN) for representation learning. Experiments show that adding the GAN-generated data effectively improves the discriminative ability of learned CNN embeddings. On three large-scale datasets, Market-1501, CUHK03 and DukeMTMC-reID, we obtain +4.37 , +1.6 and +2.46 improvement in rank-1 precision over the baseline CNN, respectively. We additionally apply the proposed method to fine-grained bird recognition and achieve a +0.6 improvement over a strong baseline. The code is available at this https URL This paper proposes an unpaired learning method for image enhancement. Given a set of photographs with the desired characteristics, the proposed method learns a photo enhancer which transforms an input image into an enhanced image with those characteristics. The method is based on the framework of two-way generative adversarial networks (GANs) with several improvements. First, we augment the U-Net with global features and show that it is more effective. The global U-Net acts as the generator in our GAN model. Second, we improve Wasserstein GAN (WGAN) with an adaptive weighting scheme. With this scheme, training converges faster and better, and is less sensitive to parameters than WGAN-GP. Finally, we propose to use individual batch normalization layers for generators in two-way GANs. It helps generators better adapt to their own input distributions. All together, they significantly improve the stability of GAN training for our application. Both quantitative and visual results show that the proposed method is effective for enhancing images.