Knowledge of what spatial elements of medical images deep learning methods use as evidence is important for model interpretability, trustiness, and validation. There is a lack of such techniques for models in regression tasks. We propose a method, called visualization for regression with a generative adversarial network (VR-GAN), for formulating adversarial training specifically for datasets containing regression target values characterizing disease severity. We use a conditional generative adversarial network where the generator attempts to learn to shift the output of a regressor through creating disease effect maps that are added to the original images. Meanwhile, the regressor is trained to predict the original regression value for the modified images. A model trained with this technique learns to provide visualization for how the image would appear at different stages of the disease. We analyze our method in a dataset of chest x-rays associated with pulmonary function tests, used for diagnosing chronic obstructive pulmonary disease (COPD). For validation, we compute the difference of two registered x-rays of the same patient at different time points and correlate it to the generated disease effect map. The proposed method outperforms a technique based on classification and provides realistic-looking images, making modifications to images following what radiologists usually observe for this disease. Implementation code is available at this https URL.
@cite_7 , researchers visualize what brain MRIs of patients with mild cognitive impairment would look like if they developed Alzheimer's disease, generating disease effect maps. To solve problems with other visualization methods, they propose an adversarial setup. A generator is trained to modify an input image which fools a discriminator. The modifications the generator outputs are used as visualization of evidence of one class. This setup inspires our method. However, instead of classification labels, we use regression values and a novel loss function.
@cite_7
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Attributing the pixels of an input image to a certain category is an important and well-studied problem in computer vision, with applications ranging from weakly supervised localisation to understanding hidden effects in the data. In recent years, approaches based on interpreting a previously trained neural network classifier have become the de facto state-of-the-art and are commonly used on medical as well as natural image datasets. In this paper, we discuss a limitation of these approaches which may lead to only a subset of the category specific features being detected. To address this problem we develop a novel feature attribution technique based on Wasserstein Generative Adversarial Networks (WGAN), which does not suffer from this limitation. We show that our proposed method performs substantially better than the state-of-the-art for visual attribution on a synthetic dataset and on real 3D neuroimaging data from patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). For AD patients the method produces compellingly realistic disease effect maps which are very close to the observed effects. Computer-aided early diagnosis of Alzheimers Disease (AD) and its prodromal form, Mild Cognitive Impairment (MCI), has been the subject of extensive research in recent years. Some recent studies have shown promising results in the AD and MCI determination using structural and functional Magnetic Resonance Imaging (sMRI, fMRI), Positron Emission Tomography (PET) and Diffusion Tensor Imaging (DTI) modalities. Furthermore, fusion of imaging modalities in a supervised machine learning framework has shown promising direction of research. In this paper we first review major trends in automatic classification methods such as feature extraction based methods as well as deep learning approaches in medical image analysis applied to the field of Alzheimer's Disease diagnostics. Then we propose our own algorithm for Alzheimer's Disease diagnostics based on a convolutional neural network and sMRI and DTI modalities fusion on hippocampal ROI using data from the Alzheimers Disease Neuroimaging Initiative (ADNI) database (this http URL). Comparison with a single modality approach shows promising results. We also propose our own method of data augmentation for balancing classes of different size and analyze the impact of the ROI size on the classification results as well. Deep neural networks are known to be vulnerable to adversarial examples, i.e., images that are maliciously perturbed to fool the model. Generating adversarial examples has been mostly limited to finding small perturbations that maximize the model prediction error. Such images, however, contain artificial perturbations that make them somewhat distinguishable from natural images. This property is used by several defense methods to counter adversarial examples by applying denoising filters or training the model to be robust to small perturbations. In this paper, we introduce a new class of adversarial examples, namely "Semantic Adversarial Examples," as images that are arbitrarily perturbed to fool the model, but in such a way that the modified image semantically represents the same object as the original image. We formulate the problem of generating such images as a constrained optimization problem and develop an adversarial transformation based on the shape bias property of human cognitive system. In our method, we generate adversarial images by first converting the RGB image into the HSV (Hue, Saturation and Value) color space and then randomly shifting the Hue and Saturation components, while keeping the Value component the same. Our experimental results on CIFAR10 dataset show that the accuracy of VGG16 network on adversarial color-shifted images is 5.7 . Deep neural networks are known to be vulnerable to adversarial examples, i.e., images that are maliciously perturbed to fool the model. Generating adversarial examples has been mostly limited to finding small perturbations that maximize the model prediction error. Such images, however, contain artificial perturbations that make them somewhat distinguishable from natural images. This property is used by several defense methods to counter adversarial examples by applying denoising filters or training the model to be robust to small perturbations. In this paper, we introduce a new class of adversarial examples, namely "Semantic Adversarial Examples," as images that are arbitrarily perturbed to fool the model, but in such a way that the modified image semantically represents the same object as the original image. We formulate the problem of generating such images as a constrained optimization problem and develop an adversarial transformation based on the shape bias property of human cognitive system. In our method, we generate adversarial images by first converting the RGB image into the HSV (Hue, Saturation and Value) color space and then randomly shifting the Hue and Saturation components, while keeping the Value component the same. Our experimental results on CIFAR10 dataset show that the accuracy of VGG16 network on adversarial color-shifted images is 5.7 .