Ability to quantify and predict progression of a disease is fundamental for selecting an appropriate treatment. Many clinical metrics cannot be acquired frequently either because of their cost (e.g. MRI, gait analysis) or because they are inconvenient or harmful to a patient (e.g. biopsy, x-ray). In such scenarios, in order to estimate individual trajectories of disease progression, it is advantageous to leverage similarities between patients, i.e. the covariance of trajectories, and find a latent representation of progression. Most of existing methods for estimating trajectories do not account for events in-between observations, what dramatically decreases their adequacy for clinical practice. In this study, we develop a machine learning framework named Coordinatewise-Soft-Impute (CSI) for analyzing disease progression from sparse observations in the presence of confounding events. CSI is guaranteed to converge to the global minimum of the corresponding optimization problem. Experimental results also demonstrates the effectiveness of CSI using both simulated and real dataset.
While the probabilistic approach of mixed-effect models offers many theoretical advantages including convergence rates and inference testing, it is often sensitive to the assumptions on distributions, some of which are hard to verify in practice. To avoid the potential bias of distributional assumptions in mixed-effect models, in @cite_8 formulate the problem as a sparse matrix completion problem. We will review this approach in the current section.
@cite_8
2951999827 2125126993 1977580401 2110355775
In this paper, we consider the matrix completion problem when the observations are one-bit measurements of some underlying matrix M, and in particular the observed samples consist only of ones and no zeros. This problem is motivated by modern applications such as recommender systems and social networks where only "likes" or "friendships" are observed. The problem of learning from only positive and unlabeled examples, called PU (positive-unlabeled) learning, has been studied in the context of binary classification. We consider the PU matrix completion problem, where an underlying real-valued matrix M is first quantized to generate one-bit observations and then a subset of positive entries is revealed. Under the assumption that M has bounded nuclear norm, we provide recovery guarantees for two different observation models: 1) M parameterizes a distribution that generates a binary matrix, 2) M is thresholded to obtain a binary matrix. For the first case, we propose a "shifted matrix completion" method that recovers M using only a subset of indices corresponding to ones, while for the second case, we propose a "biased matrix completion" method that recovers the (thresholded) binary matrix. Both methods yield strong error bounds --- if M is n by n, the Frobenius error is bounded as O(1 ((1-rho)n), where 1-rho denotes the fraction of ones observed. This implies a sample complexity of O(n n) ones to achieve a small error, when M is dense and n is large. We extend our methods and guarantees to the inductive matrix completion problem, where rows and columns of M have associated features. We provide efficient and scalable optimization procedures for both the methods and demonstrate the effectiveness of the proposed methods for link prediction (on real-world networks consisting of over 2 million nodes and 90 million links) and semi-supervised clustering tasks. We are interested in a low-rank matrix factorization problem where one of the matrix factors has a special structure; specifically, its columns live in the unit simplex. This problem finds applications in diverse areas such as hyperspectral unmixing, video summarization, spectrum sensing, and blind speech separation. Prior works showed that such a factorization problem can be formulated as a self-dictionary sparse optimization problem under some assumptions that are considered realistic in many applications, and convex mixed norms were employed as optimization surrogates to realize the factorization in practice. Numerical results have shown that the mixed-norm approach demonstrates promising performance. In this letter, we conduct performance analysis of the mixed-norm approach under noise perturbations. Our result shows that using a convex mixed norm can indeed yield provably good solutions. More importantly, we also show that using nonconvex mixed (quasi) norms is more advantageous in terms of robustness against noise. Recovering low-rank and sparse matrices from incomplete or corrupted observations is an important problem in statistics, machine learning, computer vision, as well as signal and image processing. In theory, this problem can be solved by the natural convex joint mixed relaxations (i.e., l 1 -norm and trace norm) under certain conditions. However, all current provable algorithms suffer from superlinear per-iteration cost, which severely limits their applicability to large-scale problems. In this paper, we propose a scalable, provable and structured robust bilinear factorization (RBF) method to recover low-rank and sparse matrices from missing and grossly corrupted data, i.e., robust matrix completion (RMC), or incomplete and grossly corrupted measurements, i.e., compressive principal component pursuit (CPCP). Specifically, we first present two small-scale matrix trace norm regularized bilinear factorization models for RMC and CPCP problems, in which repetitively calculating SVD of a large-scale matrix is replaced by updating two much smaller factor matrices. Then, we apply the alternating direction method of multipliers (ADMM) to efficiently solve the RMC problems. Finally, we provide the convergence analysis of our algorithm, and extend it to address general CPCP problems. Experimental results verified both the efficiency and effectiveness of our method compared with the state-of-the-art methods. Recovering structured models (e.g., sparse or group-sparse vectors, low-rank matrices) given a few linear observations have been well-studied recently. In various applications in signal processing and machine learning, the model of interest is structured in several ways, for example, a matrix that is simultaneously sparse and low rank. Often norms that promote the individual structures are known, and allow for recovery using an orderwise optimal number of measurements (e.g., @math norm for sparsity, nuclear norm for matrix rank). Hence, it is reasonable to minimize a combination of such norms. We show that, surprisingly, using multiobjective optimization with these norms can do no better, orderwise, than exploiting only one of the structures, thus revealing a fundamental limitation in sample complexity. This result suggests that to fully exploit the multiple structures, we need an entirely new convex relaxation. Further, specializing our results to the case of sparse and low-rank matrices, we show that a nonconvex formulation recovers the model from very few measurements (on the order of the degrees of freedom), whereas the convex problem combining the @math and nuclear norms requires many more measurements, illustrating a gap between the performance of the convex and nonconvex recovery problems. Our framework applies to arbitrary structure-inducing norms as well as to a wide range of measurement ensembles. This allows us to give sample complexity bounds for problems such as sparse phase retrieval and low-rank tensor completion.