Abstract Recent advances in deep learning methods have redefined the state-of-the-art for many medical imaging applications, surpassing previous approaches and sometimes even competing with human judgment in several tasks. Those models, however, when trained to reduce the empirical risk on a single domain, fail to generalize when applied to other domains, a very common scenario in medical imaging due to the variability of images and anatomical structures, even across the same imaging modality. In this work, we extend the method of unsupervised domain adaptation using self-ensembling for the semantic segmentation task and explore multiple facets of the method on a small and realistic publicly-available magnetic resonance (MRI) dataset. Through an extensive evaluation, we show that self-ensembling can indeed improve the generalization of the models even when using a small amount of unlabeled data.
Even though patch-wise methods are still being researched @cite_47 and have led to several advances in segmentation @cite_23 , the most common deep architecture for segmentation nowadays is the so-called Fully Convolutional Network (FCN) @cite_38 . This architecture is based solely on convolutional layers with the final result not depending on the use of fully-connected layers. FCNs can provide a fully-segmented image within a single forward step with variable output size depending on the input tensor size. One of the most well-known FCNs for medical imaging is U-net @cite_31 , which combines convolutional, downsampling, and upsampling operations with skip non-residual connections. We make use of U-Net throughout this work aiming for generalizable conclusions. This architecture is further discussed in .
@cite_38 @cite_47 @cite_31 @cite_23
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Fully convolutional networks (FCNs) are well known to provide state-of-the-art results in various medical image segmentation tasks. However, these models usually need a tremendous number of training samples to achieve good performances. Unfortunately, this requirement is often difficult to satisfy in the medical imaging field, due to the scarcity of labeled images. As a consequence, the common tricks for FCNs’ training go from data augmentation and transfer learning to patch-based segmentation. In the latter, the segmentation of an image involves patch extraction, patch segmentation, then patch aggregation. This paper presents a framework that takes advantage of all these tricks by starting with a patch-level segmentation which is then extended to the image level by transfer learning. The proposed framework follows two main steps. Given a image database ( D ), a first network ( N _P ) is designed and trained using patches extracted from ( D ). Then, ( N _P ) is used to pre-train a FCN ( N _I ) to be trained on the full sized images of ( D ). Experimental results are presented on the task of retinal blood vessel segmentation using the well known publicly available DRIVE database. U-Net has been providing state-of-the-art performance in many medical image segmentation problems. Many modifications have been proposed for U-Net, such as attention U-Net, recurrent residual convolutional U-Net (R2-UNet), and U-Net with residual blocks or blocks with dense connections. However, all these modifications have an encoder-decoder structure with skip connections, and the number of paths for information flow is limited. We propose LadderNet in this paper, which can be viewed as a chain of multiple U-Nets. Instead of only one pair of encoder branch and decoder branch in U-Net, a LadderNet has multiple pairs of encoder-decoder branches, and has skip connections between every pair of adjacent decoder and decoder branches in each level. Inspired by the success of ResNet and R2-UNet, we use modified residual blocks where two convolutional layers in one block share the same weights. A LadderNet has more paths for information flow because of skip connections and residual blocks, and can be viewed as an ensemble of Fully Convolutional Networks (FCN). The equivalence to an ensemble of FCNs improves segmentation accuracy, while the shared weights within each residual block reduce parameter number. Semantic segmentation is essential for retinal disease detection. We tested LadderNet on two benchmark datasets for blood vessel segmentation in retinal images, and achieved superior performance over methods in the literature. The implementation is provided https: github.com juntang-zhuang LadderNet Recent advances in deep learning, like 3D fully convolutional networks (FCNs), have improved the state-of-the-art in dense semantic segmentation of medical images. However, most network architectures require severely downsampling or cropping the images to meet the memory limitations of today's GPU cards while still considering enough context in the images for accurate segmentation. In this work, we propose a novel approach that utilizes auto-context to perform semantic segmentation at higher resolutions in a multi-scale pyramid of stacked 3D FCNs. We train and validate our models on a dataset of manually annotated abdominal organs and vessels from 377 clinical CT images used in gastric surgery, and achieve promising results with close to 90 Dice score on average. For additional evaluation, we perform separate testing on datasets from different sources and achieve competitive results, illustrating the robustness of the model and approach. In this paper, we study the influence of both long and short skip connections on Fully Convolutional Networks (FCN) for biomedical image segmentation. In standard FCNs, only long skip connections are used to skip features from the contracting path to the expanding path in order to recover spatial information lost during downsampling. We extend FCNs by adding short skip connections, that are similar to the ones introduced in residual networks, in order to build very deep FCNs (of hundreds of layers). A review of the gradient flow confirms that for a very deep FCN it is beneficial to have both long and short skip connections. Finally, we show that a very deep FCN can achieve near-to-state-of-the-art results on the EM dataset without any further post-processing.