Our aging population increasingly suffers from multiple chronic diseases simultaneously, necessitating the comprehensive treatment of these conditions. Finding the optimal set of drugs for a combinatorial set of diseases is a combinatorial pattern exploration problem. Association rule mining is a popular tool for such problems, but the requirement of health care for finding causal, rather than associative, patterns renders association rule mining unsuitable. To address this issue, we propose a novel framework based on the Rubin-Neyman causal model for extracting causal rules from observational data, correcting for a number of common biases. Specifically, given a set of interventions and a set of items that define subpopulations (e.g., diseases), we wish to find all subpopulations in which effective intervention combinations exist and in each such subpopulation, we wish to find all intervention combinations such that dropping any intervention from this combination will reduce the efficacy of the treatment. A key aspect of our framework is the concept of closed intervention sets which extend the concept of quantifying the effect of a single intervention to a set of concurrent interventions. We also evaluated our causal rule mining framework on the Electronic Health Records (EHR) data of a large cohort of patients from Mayo Clinic and showed that the patterns we extracted are sufficiently rich to explain the controversial findings in the medical literature regarding the effect of a class of cholesterol drugs on Type-II Diabetes Mellitus (T2DM).
Knowing the correct graph structure is important, because substructures in the graph are suggestive of sources of bias. To correct for biases, we are looking for specific substructures. For example, causal chains can be sources of overcorrection bias and "V"-shaped structures can be indicative of confounding or endogenous selection bias @cite_13 . Many other interesting substructures have been studied @cite_5 @cite_16 @cite_11 . In our work, we consider three fundamental such structures: direct causal effect, indirect causal effect and confounding. Of these, confounding is the most severe and received the most research interest.
@cite_5 @cite_16 @cite_13 @cite_11
2134652049 1845768777 2001667451 2962850650
Causal discovery becomes especially challenging when the possibility of latent confounding and or selection bias is not assumed away. For this task, ancestral graph models are particularly useful in that they can represent the presence of latent confounding and selection effect, without explicitly invoking unobserved variables. Based on the machinery of ancestral graphs, there is a provably sound causal discovery algorithm, known as the FCI algorithm, that allows the possibility of latent confounders and selection bias. However, the orientation rules used in the algorithm are not complete. In this paper, we provide additional orientation rules, augmented by which the FCI algorithm is shown to be complete, in the sense that it can, under standard assumptions, discover all aspects of the causal structure that are uniquely determined by facts of probabilistic dependence and independence. The result is useful for developing any causal discovery and reasoning system based on ancestral graph models. There are several existing algorithms that under appropriate assumptions can reliably identify a subset of the underlying causal relationships from observational data. This paper introduces the first computationally feasible score-based algorithm that can reliably identify causal relationships in the large sample limit for discrete models, while allowing for the possibility that there are unobserved common causes. In doing so, the algorithm does not ever need to assign scores to causal structures with unobserved common causes. The algorithm is based on the identification of so called Y substructures within Bayesian network structures that can be learned from observational data. An example of a Y substructure is A -> C, B -> C, C -> D. After providing background on causal discovery, the paper proves the conditions under which the algorithm is reliable in the large sample limit. Determining interrelatedness structure of various entities from multiple time series data is of significant interest to many areas. Knowledge of such a structure can aid in identifying cause and effect relationships, clustering of similar entities, identification of representative elements and model reduction. The majority of existing results are based on correlation based indices which effectively assume a static relationship between the time series data and are not suitable for detecting interrelatedness when the time series are dynamically related or when the time series involve loops. In this paper, a methodology for identifying the interrelatedness structure of dynamically related time series data is presented that also allows for the presence of loops in the connectivity structure. A linear dynamic graph model is presented where it is assumed that each time series data is the sum of an independent stochastic noise source and a dynamically weighted sum of other time series data. A link is assumed to be present between two time series if the weight of a time series, which is a linear time-invariant filter, is nonzero in the formation of the other. Reconstruction of the link connectivity structure under various scenarios is considered. It is shown that when the linear dynamic graph is allowed to admit non-causal weights, then the links structure can be recovered with the possibility of identifying spurious connections. However, it is shown that the spurious links remain local, where, a spurious link is restricted to be within one hop of a true link. Furthermore, strategies for exact reconstruction of the link structure when the weights are restricted to be causal are developed. The main tools for determining the network topology are based on variations of Wiener filtering. A significant insight provided by the article is that, in the class of network models considered in the paper, the Wiener filter estimating a stochastic process based on other processes remains local in the sense that the Wiener filter utilizes only measurements local to the node being estimated. Knowledge graphs contain knowledge about the world and provide a structured representation of this knowledge. Current knowledge graphs contain only a small subset of what is true in the world. Link prediction approaches aim at predicting new links for a knowledge graph given the existing links between the entities. Tensor factorization approaches have proved promising for such link prediction problems. Proposed in 1927, Canonical Polyadic (CP) decomposition is among the first tensor factorization approaches. CP generally performs poorly for link prediction as it learns two independent embedding vectors for each entity, whereas they are really tied. We present a simple enhancement (which we call SimplE) of CP to allow the two embeddings of each entity to be learned dependently. The complexity of SimplE grows linearly with the size of embeddings. The embeddings learned through SimplE are interpretable, and certain types of background knowledge in terms of logical rules can be incorporated into these embeddings through weight tying. We prove SimplE is fully-expressive and derive a bound on the size of its embeddings for full expressivity. We show empirically that, despite its simplicity, SimplE outperforms several state-of-the-art tensor factorization techniques.