Deep learning methods for classifying medical images have demonstrated impressive accuracy in a wide range of tasks but often these models are hard to interpret, limiting their applicability in clinical practice. In this work we introduce a convolutional neural network model for identifying disease in temporal sequences of cardiac MR segmentations which is interpretable in terms of clinically familiar measurements. The model is based around a variational autoencoder, reducing the input into a low-dimensional latent space in which classification occurs. We then use the recently developed concept activation vector' technique to associate concepts which are diagnostically meaningful (eg. clinical biomarkers such as low left-ventricular ejection fraction') to certain vectors in the latent space. These concepts are then qualitatively inspected by observing the change in the image domain resulting from interpolations in the latent space in the direction of these vectors. As a result, when the model classifies images it is also capable of providing naturally interpretable concepts relevant to that classification and demonstrating the meaning of those concepts in the image domain. Our approach is demonstrated on the UK Biobank cardiac MRI dataset where we detect the presence of coronary artery disease.
When a model is too complex for its entire decision process to be understood, interpretability is still possible by supplementing the output decision with information which can help to explain it. Saliency maps @cite_10 are a commonly used approach for interpreting image classification in which the gradient of the loss with respect to the input image is visualised. Although saliency maps can be useful for highlighting relevant regions of images, the level of interpretability that they can provide is often of limited use. Firstly, as explained in @cite_12 , , which is clearly undesirable. Secondly, as noted in @cite_11 , saliency methods only explain where the network is looking'. If an image of a dog is misclassified as a cat, and a saliency map highlights the region of the image containing the dog, we still do not know much about why this image was misclassified. Thirdly, the explanation is only relevant for the particular image in question and so an observer must manually assess many images and their saliency maps to draw more general conclusions @cite_5 .
@cite_5 @cite_10 @cite_12 @cite_11
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In order for machine learning to be deployed and trusted in many applications, it is crucial to be able to reliably explain why the machine learning algorithm makes certain predictions. For example, if an algorithm classifies a given pathology image to be a malignant tumor, then the doctor may need to know which parts of the image led the algorithm to this classification. How to interpret black-box predictors is thus an important and active area of research. A fundamental question is: how much can we trust the interpretation itself? In this paper, we show that interpretation of deep learning predictions is extremely fragile in the following sense: two perceptively indistinguishable inputs with the same predicted label can be assigned very different interpretations. We systematically characterize the fragility of several widely-used feature-importance interpretation methods (saliency maps, relevance propagation, and DeepLIFT) on ImageNet and CIFAR-10. Our experiments show that even small random perturbation can change the feature importance and new systematic perturbations can lead to dramatically different interpretations without changing the label. We extend these results to show that interpretations based on exemplars (e.g. influence functions) are similarly fragile. Our analysis of the geometry of the Hessian matrix gives insight on why fragility could be a fundamental challenge to the current interpretation approaches. Salient object detection increasingly receives attention as an important component or step in several pattern recognition and image processing tasks. Although a variety of powerful saliency models have been intensively proposed, they usually involve heavy feature (or model) engineering based on priors (or assumptions) about the properties of objects and backgrounds. Inspired by the effectiveness of recently developed feature learning, we provide a novel deep image saliency computing (DISC) framework for fine-grained image saliency computing. In particular, we model the image saliency from both the coarse-and fine-level observations, and utilize the deep convolutional neural network (CNN) to learn the saliency representation in a progressive manner. In particular, our saliency model is built upon two stacked CNNs. The first CNN generates a coarse-level saliency map by taking the overall image as the input, roughly identifying saliency regions in the global context. Furthermore, we integrate superpixel-based local context information in the first CNN to refine the coarse-level saliency map. Guided by the coarse saliency map, the second CNN focuses on the local context to produce fine-grained and accurate saliency map while preserving object details. For a testing image, the two CNNs collaboratively conduct the saliency computing in one shot. Our DISC framework is capable of uniformly highlighting the objects of interest from complex background while preserving well object details. Extensive experiments on several standard benchmarks suggest that DISC outperforms other state-of-the-art methods and it also generalizes well across data sets without additional training. The executable version of DISC is available online: http: vision.sysu.edu.cn projects DISC . Clearly explaining a rationale for a classification decision to an end user can be as important as the decision itself. Existing approaches for deep visual recognition are generally opaque and do not output any justification text; contemporary vision-language models can describe image content but fail to take into account class-discriminative image aspects which justify visual predictions. We propose a new model that focuses on the discriminating properties of the visible object, jointly predicts a class label, and explains why the predicted label is appropriate for the image. Through a novel loss function based on sampling and reinforcement learning, our model learns to generate sentences that realize a global sentence property, such as class specificity. Our results on the CUB dataset show that our model is able to generate explanations which are not only consistent with an image but also more discriminative than descriptions produced by existing captioning methods. Visual saliency is a fundamental problem in both cognitive and computational sciences, including computer vision. In this paper, we discover that a high-quality visual saliency model can be learned from multiscale features extracted using deep convolutional neural networks (CNNs), which have had many successes in visual recognition tasks. For learning such saliency models, we introduce a neural network architecture, which has fully connected layers on top of CNNs responsible for feature extraction at three different scales. We then propose a refinement method to enhance the spatial coherence of our saliency results. Finally, aggregating multiple saliency maps computed for different levels of image segmentation can further boost the performance, yielding saliency maps better than those generated from a single segmentation. To promote further research and evaluation of visual saliency models, we also construct a new large database of 4447 challenging images and their pixelwise saliency annotations. Experimental results demonstrate that our proposed method is capable of achieving state-of-the-art performance on all public benchmarks, improving the F-Measure by 5.0 and 13.2 respectively on the MSRA-B dataset and our new dataset (HKU-IS), and lowering the mean absolute error by 5.7 and 35.1 respectively on these two datasets.