Given the wide success of convolutional neural networks (CNNs) applied to natural images, researchers have begun to apply them to neuroimaging data. To date, however, exploration of novel CNN architectures tailored to neuroimaging data has been limited. Several recent works fail to leverage the 3D structure of the brain, instead treating the brain as a set of independent 2D slices. Approaches that do utilize 3D convolutions rely on architectures developed for object recognition tasks in natural 2D images. Such architectures make assumptions about the input that may not hold for neuroimaging. For example, existing architectures assume that patterns in the brain exhibit translation invariance. However, a pattern in the brain may have different meaning depending on where in the brain it is located. There is a need to explore novel architectures that are tailored to brain images. We present two simple modifications to existing CNN architectures based on brain image structure. Applied to the task of brain age prediction, our network achieves a mean absolute error (MAE) of 1.4 years and trains 30 faster than a CNN baseline that achieves a MAE of 1.6 years. Our results suggest that lessons learned from developing models on natural images may not directly transfer to neuroimaging tasks. Instead, there remains a large space of unexplored questions regarding model development in this area, whose answers may differ from conventional wisdom.
Predicting age from brain images is an important step towards understanding typical brain development and further understanding developmental disorders . While there has been a lot of progress on the task of developing machine learning techniques for predicting age from brain images , here we focus primarily on those works that utilize CNNs. @cite_4 propose a CNN architecture with repeated blocks of 3D, @math convolutions. Their focus is not on comparing different CNN architectures, but rather comparing the performance of their proposed architecture to a Gaussian Process model.
@cite_4
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Abstract Machine learning analysis of neuroimaging data can accurately predict chronological age in healthy people. Deviations from healthy brain ageing have been associated with cognitive impairment and disease. Here we sought to further establish the credentials of ‘brain-predicted age’ as a biomarker of individual differences in the brain ageing process, using a predictive modelling approach based on deep learning, and specifically convolutional neural networks (CNN), and applied to both pre-processed and raw T1-weighted MRI data. Firstly, we aimed to demonstrate the accuracy of CNN brain-predicted age using a large dataset of healthy adults (N = 2001). Next, we sought to establish the heritability of brain-predicted age using a sample of monozygotic and dizygotic female twins (N = 62). Thirdly, we examined the test-retest and multi-centre reliability of brain-predicted age using two samples (within-scanner N = 20; between-scanner N = 11). CNN brain-predicted ages were generated and compared to a Gaussian Process Regression (GPR) approach, on all datasets. Input data were grey matter (GM) or white matter (WM) volumetric maps generated by Statistical Parametric Mapping (SPM) or raw data. CNN accurately predicted chronological age using GM (correlation between brain-predicted age and chronological age r = 0.96, mean absolute error [MAE] = 4.16 years) and raw (r = 0.94, MAE = 4.65 years) data. This was comparable to GPR brain-predicted age using GM data (r = 0.95, MAE = 4.66 years). Brain-predicted age was a heritable phenotype for all models and input data (h 2 ≥ 0.5). Brain-predicted age showed high test-retest reliability (intraclass correlation coefficient [ICC] = 0.90–0.99). Multi-centre reliability was more variable within high ICCs for GM (0.83–0.96) and poor-moderate levels for WM and raw data (0.51–0.77). Brain-predicted age represents an accurate, highly reliable and genetically-influenced phenotype, that has potential to be used as a biomarker of brain ageing. Moreover, age predictions can be accurately generated on raw T1-MRI data, substantially reducing computation time for novel data, bringing the process closer to giving real-time information on brain health in clinical settings. In this paper, we address the problem of apparent age estimation. Different from estimating the real age of individuals, in which each face image has a single age label, in this problem, face images have multiple age labels, corresponding to the ages perceived by the annotators, when they look at these images. This provides an intriguing computer vision problem, since in generic image or object classification tasks, it is typical to have a single ground truth label per class. To account for multiple labels per image, instead of using average age of the annotated face image as the class label, we have grouped the face images that are within a specified age range. Using these age groups and their age-shifted groupings, we have trained an ensemble of deep learning models. Before feeding an input face image to a deep learning model, five facial landmark points are detected and used for 2-D alignment. We have employed and fine tuned convolutional neural networks (CNNs) that are based on VGG-16 [24] architecture and pretrained on the IMDB-WIKI dataset [22]. The outputs of these deep learning models are then combined to produce the final estimation. Proposed method achieves 0.3668 error in the final ChaLearn LAP 2016 challenge test set [5]. In this paper we tackle the estimation of apparent age in still face images with deep learning. Our convolutional neural networks (CNNs) use the VGG-16 architecture [13] and are pretrained on ImageNet for image classification. In addition, due to the limited number of apparent age annotated images, we explore the benefit of finetuning over crawled Internet face images with available age. We crawled 0.5 million images of celebrities from IMDB and Wikipedia that we make public. This is the largest public dataset for age prediction to date. We pose the age regression problem as a deep classification problem followed by a softmax expected value refinement and show improvements over direct regression training of CNNs. Our proposed method, Deep EXpectation (DEX) of apparent age, first detects the face in the test image and then extracts the CNN predictions from an ensemble of 20 networks on the cropped face. The CNNs of DEX were finetuned on the crawled images and then on the provided images with apparent age annotations. DEX does not use explicit facial landmarks. Our DEX is the winner (1st place) of the ChaLearn LAP 2015 challenge on apparent age estimation with 115 registered teams, significantly outperforming the human reference. Abstract Convolutional Neural Networks (CNNs) have been proven very effective for human demographics estimation by a number of recent studies. However, the proposed solutions significantly vary in different aspects leaving many open questions on how to choose an optimal CNN architecture and which training strategy to use. In this work, we shed light on some of these questions improving the existing CNN-based approaches for gender and age prediction and providing practical hints for future studies. In particular, we analyse four important factors of the CNN training for gender recognition and age estimation: (1) the target age encoding and loss function, (2) the CNN depth, (3) the need for pretraining, and (4) the training strategy: mono-task or multi-task. As a result, we design the state-of-the-art gender recognition and age estimation models according to three popular benchmarks: LFW, MORPH-II and FG-NET . Moreover, our best model won the ChaLearn Apparent Age Estimation Challenge 2016 significantly outperforming the solutions of other participants.