Quantification of anatomical shape changes still relies on scalar global indexes which are largely insensitive to regional or asymmetric modifications. Accurate assessment of pathology-driven anatomical remodeling is a crucial step for the diagnosis and treatment of heart conditions. Deep learning approaches have recently achieved wide success in the analysis of medical images, but they lack interpretability in the feature extraction and decision processes. In this work, we propose a new interpretable deep learning model for shape analysis. In particular, we exploit deep generative networks to model a population of anatomical segmentations through a hierarchy of conditional latent variables. At the highest level of this hierarchy, a two-dimensional latent space is simultaneously optimised to discriminate distinct clinical conditions, enabling the direct visualisation of the classification space. Moreover, the anatomical variability encoded by this discriminative latent space can be visualised in the segmentation space thanks to the generative properties of the model, making the classification task transparent. This approach yielded high accuracy in the categorisation of healthy and remodelled hearts when tested on unseen segmentations from our own multi-centre dataset as well as in an external validation set. More importantly, it enabled the visualisation in three-dimensions of the most discriminative anatomical features between the two conditions. The proposed approach scales effectively to large populations, facilitating high-throughput analysis of normal anatomy and pathology in large-scale studies of volumetric imaging.
* Contributions In this paper, we aim to extend our preliminary work @cite_28 on classification and visualisation of discriminative features by employing LVAEs, with the aim of assisting clinicians in quantifying the morphological changes related to disease, and in order to develop medical image classifiers that can visualise the morphological features driving the classification result. The main contributions of this work can be described as follows:
@cite_28
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In many visual classification tasks the spatial distribution of discriminative information is (i) non uniform e.g. person ‘reading’ can be distinguished from ‘taking a photo’ based on the area around the arms i.e. ignoring the legs and (ii) has intra class variations e.g. different readers may hold the books differently. Motivated by these observations, we propose to learn the discriminative spatial saliency of images while simultaneously learning a max margin classifier for a given visual classification task. Using the saliency maps to weight the corresponding visual features improves the discriminative power of the image representation. We treat the saliency maps as latent variables and allow them to adapt to the image content to maximize the classification score, while regularizing the change in the saliency maps. Our experimental results on three challenging datasets, for (i) human action classification, (ii) fine grained classification and (iii) scene classification, demonstrate the effectiveness and wide applicability of the method. In this chapter we study the problem of classifying human–object interaction activities in still images. The goal of our method is to explore fine image statistics and identify the discriminative image patches for recognition. We achieve this goal by combining two ideas, discriminative feature mining and randomization. Discriminative feature mining allows us to model the detailed information that distinguishes different classes of images, while randomization allows us to handle the huge feature space and prevent over-fitting. We propose a random forest with discriminative decision trees algorithm where every tree node is a discriminative classifier that is trained by combining the information in this node as well as all upstream nodes. Besides human action recognition in still images, we also evaluate our method on subordinate categorization. Experimental results show that our method identifies semantically meaningful visual information and outperforms state-of-the-art algorithms on various datasets. Using our method, we achieved the best results and won the award in PASCAL VOC action classification challenges in 2011 and 2012. In this paper, we propose a new classification method for five categories of lung tissues in high-resolution computed tomography (HRCT) images, with feature-based image patch approximation. We design two new feature descriptors for higher feature descriptiveness, namely the rotation-invariant Gabor-local binary patterns (RGLBP) texture descriptor and multi-coordinate histogram of oriented gradients (MCHOG) gradient descriptor. Together with intensity features, each image patch is then labeled based on its feature approximation from reference image patches. And a new patch-adaptive sparse approximation (PASA) method is designed with the following main components: minimum discrepancy criteria for sparse-based classification, patch-specific adaptation for discriminative approximation, and feature-space weighting for distance computation. The patch-wise labelings are then accumulated as probabilistic estimations for region-level classification. The proposed method is evaluated on a publicly available ILD database, showing encouraging performance improvements over the state-of-the-arts. In this paper, two supervised methods for enhancing the classification accuracy of the Nonnegative Matrix Factorization (NMF) algorithm are presented. The idea is to extend the NMF algorithm in order to extract features that enforce not only the spatial locality, but also the separability between classes in a discriminant manner. The first method employs discriminant analysis in the features derived from NMF. In this way, a two-phase discriminant feature extraction procedure is implemented, namely NMF plus Linear Discriminant Analysis (LDA). The second method incorporates the discriminant constraints inside the NMF decomposition. Thus, a decomposition of a face to its discriminant parts is obtained and new update rules for both the weights and the basis images are derived. The introduced methods have been applied to the problem of frontal face verification using the well-known XM2VTS database. Both methods greatly enhance the performance of NMF for frontal face verification