In this paper, we present a novel neural network architecture for retinal vessel segmentation that improves over the state of the art on two benchmark datasets, is the first to run in real time on high resolution images, and its small memory and processing requirements make it deployable in mobile and embedded systems. The M2U-Net has a new encoder-decoder architecture that is inspired by the U-Net. It adds pretrained components of MobileNetV2 in the encoder part and novel contractive bottleneck blocks in the decoder part that, combined with bilinear upsampling, drastically reduce the parameter count to 0.55M compared to 31.03M in the original U-Net. We have evaluated its performance against a wide body of previously published results on three public datasets. On two of them, the M2U-Net achieves new state-of-the-art performance by a considerable margin. When implemented on a GPU, our method is the first to achieve real-time inference speeds on high-resolution fundus images. We also implemented our proposed network on an ARM-based embedded system where it segments images in between 0.6 and 15 sec, depending on the resolution. Thus, the M2U-Net enables a number of applications of retinal vessel structure extraction, such as early diagnosis of eye diseases, retinal biometric authentication systems, and robot assisted microsurgery.
Liskowski and Krawiec @cite_12 propose a patch-based approach, where a network that consists of a stack of convolutional layers followed by three fully-connected layers is trained with small patches of the input fundus image. In contrast, Maninis al @cite_35 and Yan al @cite_10 train their networks with complete fundus images.
@cite_35 @cite_10 @cite_12
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Convolutional Neural Networks (CNN) are state-of-the-art models for many image classification tasks. However, to recognize cancer subtypes automatically, training a CNN on gigapixel resolution Whole Slide Tissue Images (WSI) is currently computationally impossible. The differentiation of cancer subtypes is based on cellular-level visual features observed on image patch scale. Therefore, we argue that in this situation, training a patch-level classifier on image patches will perform better than or similar to an image-level classifier. The challenge becomes how to intelligently combine patch-level classification results and model the fact that not all patches will be discriminative. We propose to train a decision fusion model to aggregate patch-level predictions given by patch-level CNNs, which to the best of our knowledge has not been shown before. Furthermore, we formulate a novel Expectation-Maximization (EM) based method that automatically locates discriminative patches robustly by utilizing the spatial relationships of patches. We apply our method to the classification of glioma and non-small-cell lung carcinoma cases into subtypes. The classification accuracy of our method is similar to the inter-observer agreement between pathologists. Although it is impossible to train CNNs on WSIs, we experimentally demonstrate using a comparable non-cancer dataset of smaller images that a patch-based CNN can outperform an image-based CNN. We propose an unsupervised method for learning multi-stage hierarchies of sparse convolutional features. While sparse coding has become an increasingly popular method for learning visual features, it is most often trained at the patch level. Applying the resulting filters convolutionally results in highly redundant codes because overlapping patches are encoded in isolation. By training convolutionally over large image windows, our method reduces the redudancy between feature vectors at neighboring locations and improves the efficiency of the overall representation. In addition to a linear decoder that reconstructs the image from sparse features, our method trains an efficient feed-forward encoder that predicts quasi-sparse features from the input. While patch-based training rarely produces anything but oriented edge detectors, we show that convolutional training produces highly diverse filters, including center-surround filters, corner detectors, cross detectors, and oriented grating detectors. We show that using these filters in multistage convolutional network architecture improves performance on a number of visual recognition and detection tasks. This paper investigates problems of image style, aesthetics, and quality estimation, which require fine-grained details from high-resolution images, utilizing deep neural network training approach. Existing deep convolutional neural networks mostly extracted one patch such as a down-sized crop from each image as a training example. However, one patch may not always well represent the entire image, which may cause ambiguity during training. We propose a deep multi-patch aggregation network training approach, which allows us to train models using multiple patches generated from one image. We achieve this by constructing multiple, shared columns in the neural network and feeding multiple patches to each of the columns. More importantly, we propose two novel network layers (statistics and sorting) to support aggregation of those patches. The proposed deep multi-patch aggregation network integrates shared feature learning and aggregation function learning into a unified framework. We demonstrate the effectiveness of the deep multi-patch aggregation network on the three problems, i.e., image style recognition, aesthetic quality categorization, and image quality estimation. Our models trained using the proposed networks significantly outperformed the state of the art in all three applications. Feedforward multilayer networks trained by supervised learning have recently demonstrated state of the art performance on image labeling problems such as boundary prediction and scene parsing. As even very low error rates can limit practical usage of such systems, methods that perform closer to human accuracy remain desirable. In this work, we propose a new type of network with the following properties that address what we hypothesize to be limiting aspects of existing methods: (1) a wide' structure with thousands of features, (2) a large field of view, (3) recursive iterations that exploit statistical dependencies in label space, and (4) a parallelizable architecture that can be trained in a fraction of the time compared to benchmark multilayer convolutional networks. For the specific image labeling problem of boundary prediction, we also introduce a novel example weighting algorithm that improves segmentation accuracy. Experiments in the challenging domain of connectomic reconstruction of neural circuity from 3d electron microscopy data show that these "Deep And Wide Multiscale Recursive" (DAWMR) networks lead to new levels of image labeling performance. The highest performing architecture has twelve layers, interwoven supervised and unsupervised stages, and uses an input field of view of 157,464 voxels ( @math ) to make a prediction at each image location. We present an associated open source software package that enables the simple and flexible creation of DAWMR networks.