Deep convolutional neural networks have achieved great success in various applications. However, training an effective DNN model for a specific task is rather challenging because it requires a prior knowledge or experience to design the network architecture, repeated trial-and-error process to tune the parameters, and a large set of labeled data to train the model. In this paper, we propose to overcome these challenges by actively adapting a pre-trained model to a new task with less labeled examples. Specifically, the pre-trained model is iteratively fine tuned based on the most useful examples. The examples are actively selected based on a novel criterion, which jointly estimates the potential contribution of an instance on optimizing the feature representation as well as improving the classification model for the target task. On one hand, the pre-trained model brings plentiful information from its original task, avoiding redesign of the network architecture or training from scratch; and on the other hand, the labeling cost can be significantly reduced by active label querying. Experiments on multiple datasets and different pre-trained models demonstrate that the proposed approach can achieve cost-effective training of DNNs.
There is one study trying to actively fine tune a pre-trained deep neural network for biomedical image analysis @cite_15 . The authors propose a new criterion to estimate the diversity among different patches extracted from the same image, and expect the image with more diverse patches is more useful for updating the model. However, this method is specially designed for biomedical image analysis, and can only handle binary classification problems, which strongly restricts its application.
@cite_15
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Training a deep convolutional neural network (CNN) from scratch is difficult because it requires a large amount of labeled training data and a great deal of expertise to ensure proper convergence. A promising alternative is to fine-tune a CNN that has been pre-trained using, for instance, a large set of labeled natural images. However, the substantial differences between natural and medical images may advise against such knowledge transfer. In this paper, we seek to answer the following central question in the context of medical image analysis: Can the use of pre-trained deep CNNs with sufficient fine-tuning eliminate the need for training a deep CNN from scratch? To address this question, we considered four distinct medical imaging applications in three specialties (radiology, cardiology, and gastroenterology) involving classification, detection, and segmentation from three different imaging modalities, and investigated how the performance of deep CNNs trained from scratch compared with the pre-trained CNNs fine-tuned in a layer-wise manner. Our experiments consistently demonstrated that 1) the use of a pre-trained CNN with adequate fine-tuning outperformed or, in the worst case, performed as well as a CNN trained from scratch; 2) fine-tuned CNNs were more robust to the size of training sets than CNNs trained from scratch; 3) neither shallow tuning nor deep tuning was the optimal choice for a particular application; and 4) our layer-wise fine-tuning scheme could offer a practical way to reach the best performance for the application at hand based on the amount of available data. Convolutional Neural Networks (CNN) are state-of-the-art models for many image classification tasks. However, to recognize cancer subtypes automatically, training a CNN on gigapixel resolution Whole Slide Tissue Images (WSI) is currently computationally impossible. The differentiation of cancer subtypes is based on cellular-level visual features observed on image patch scale. Therefore, we argue that in this situation, training a patch-level classifier on image patches will perform better than or similar to an image-level classifier. The challenge becomes how to intelligently combine patch-level classification results and model the fact that not all patches will be discriminative. We propose to train a decision fusion model to aggregate patch-level predictions given by patch-level CNNs, which to the best of our knowledge has not been shown before. Furthermore, we formulate a novel Expectation-Maximization (EM) based method that automatically locates discriminative patches robustly by utilizing the spatial relationships of patches. We apply our method to the classification of glioma and non-small-cell lung carcinoma cases into subtypes. The classification accuracy of our method is similar to the inter-observer agreement between pathologists. Although it is impossible to train CNNs on WSIs, we experimentally demonstrate using a comparable non-cancer dataset of smaller images that a patch-based CNN can outperform an image-based CNN. This paper investigates problems of image style, aesthetics, and quality estimation, which require fine-grained details from high-resolution images, utilizing deep neural network training approach. Existing deep convolutional neural networks mostly extracted one patch such as a down-sized crop from each image as a training example. However, one patch may not always well represent the entire image, which may cause ambiguity during training. We propose a deep multi-patch aggregation network training approach, which allows us to train models using multiple patches generated from one image. We achieve this by constructing multiple, shared columns in the neural network and feeding multiple patches to each of the columns. More importantly, we propose two novel network layers (statistics and sorting) to support aggregation of those patches. The proposed deep multi-patch aggregation network integrates shared feature learning and aggregation function learning into a unified framework. We demonstrate the effectiveness of the deep multi-patch aggregation network on the three problems, i.e., image style recognition, aesthetic quality categorization, and image quality estimation. Our models trained using the proposed networks significantly outperformed the state of the art in all three applications. Remarkable progress has been made in image recognition, primarily due to the availability of large-scale annotated datasets and deep convolutional neural networks (CNNs). CNNs enable learning data-driven, highly representative, hierarchical image features from sufficient training data. However, obtaining datasets as comprehensively annotated as ImageNet in the medical imaging domain remains a challenge. There are currently three major techniques that successfully employ CNNs to medical image classification: training the CNN from scratch, using off-the-shelf pre-trained CNN features, and conducting unsupervised CNN pre-training with supervised fine-tuning. Another effective method is transfer learning, i.e., fine-tuning CNN models pre-trained from natural image dataset to medical image tasks. In this paper, we exploit three important, but previously understudied factors of employing deep convolutional neural networks to computer-aided detection problems. We first explore and evaluate different CNN architectures. The studied models contain 5 thousand to 160 million parameters, and vary in numbers of layers. We then evaluate the influence of dataset scale and spatial image context on performance. Finally, we examine when and why transfer learning from pre-trained ImageNet (via fine-tuning) can be useful. We study two specific computer-aided detection (CADe) problems, namely thoraco-abdominal lymph node (LN) detection and interstitial lung disease (ILD) classification. We achieve the state-of-the-art performance on the mediastinal LN detection, and report the first five-fold cross-validation classification results on predicting axial CT slices with ILD categories. Our extensive empirical evaluation, CNN model analysis and valuable insights can be extended to the design of high performance CAD systems for other medical imaging tasks.