Deep learning algorithms offer a powerful means to automatically analyze the content of medical images. However, many biological samples of interest are primarily transparent to visible light and contain features that are difficult to resolve with a standard optical microscope. Here, we use a convolutional neural network (CNN) not only to classify images, but also to optimize the physical layout of the imaging device itself. We increase the classification accuracy of a microscope's recorded images by merging an optical model of image formation into the pipeline of a CNN. The resulting network simultaneously determines an ideal illumination arrangement to highlight important sample features during image acquisition, along with a set of convolutional weights to classify the detected images post-capture. We demonstrate our joint optimization technique with an experimental microscope configuration that automatically identifies malaria-infected cells with 5-10 higher accuracy than standard and alternative microscope lighting designs.
Deep learning networks for conventional @cite_4 and biomedical @cite_1 image classification are now commonplace and much of this recent work relies on CNNs. However, as noted above, most studies in this area do not try to use deep learning to optimize the acquisition process for their image data sets. While early work has shown that simple neural networks offer an effective way to design cameras @cite_17 , one of the first works to consider this question in the context of CNN-based learning was presented recently by Chakrabarti @cite_5 , who designed an optimal pixel-level color filter layout for color image reconstruction that outperformed the standard Bayer filter pattern.
@cite_1 @cite_5 @cite_4 @cite_17
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Deep convolutional neural networks (CNN) have seen tremendous success in large-scale generic object recognition. In comparison with generic object recognition, fine-grained image classification (FGIC) is much more challenging because (i) fine-grained labeled data is much more expensive to acquire (usually requiring domain expertise); (ii) there exists large intra-class and small inter-class variance. Most recent work exploiting deep CNN for image recognition with small training data adopts a simple strategy: pre-train a deep CNN on a large-scale external dataset (e.g., ImageNet) and fine-tune on the small-scale target data to fit the specific classification task. In this paper, beyond the fine-tuning strategy, we propose a systematic framework of learning a deep CNN that addresses the challenges from two new perspectives: (i) identifying easily annotated hyper-classes inherent in the fine-grained data and acquiring a large number of hyper-class-labeled images from readily available external sources (e.g., image search engines), and formulating the problem into multitask learning; (ii) a novel learning model by exploiting a regularization between the fine-grained recognition model and the hyper-class recognition model. We demonstrate the success of the proposed framework on two small-scale fine-grained datasets (Stanford Dogs and Stanford Cars) and on a large-scale car dataset that we collected. Recently, neuron activations extracted from a pre-trained convolutional neural network (CNN) show promising performance in various visual tasks. However, due to the domain and task bias, using the features generated from the model pre-trained for image classification as image representations for instance retrieval is problematic. In this paper, we propose quartet-net learning to improve the discriminative power of CNN features for instance retrieval. The general idea is to map the features into a space where the image similarity can be better evaluated. Our network differs from the traditional Siamese-net in two ways. First, we adopt a double-margin contrastive loss with a dynamic margin tuning strategy to train the network which leads to more robust performance. Second, we introduce in the mimic learning regularization to improve the generalization ability of the network by preventing it from overfitting to the training data. Catering for the network learning, we collect a large-scale dataset, namely GeoPair, which consists of 68k matching image pairs and 63k non-matching pairs. Experiments on several standard instance retrieval datasets demonstrate the effectiveness of our method. Convolutional neural networks (CNN) have recently shown outstanding image classification performance in the large- scale visual recognition challenge (ILSVRC2012). The suc- cess of CNNs is attributed to their ability to learn rich mid- level image representations as opposed to hand-designed low-level features used in other image classification meth- ods. Learning CNNs, however, amounts to estimating mil- lions of parameters and requires a very large number of annotated image samples. This property currently prevents application of CNNs to problems with limited training data. In this work we show how image representations learned with CNNs on large-scale annotated datasets can be effi- ciently transferred to other visual recognition tasks with limited amount of training data. We design a method to reuse layers trained on the ImageNet dataset to compute mid-level image representation for images in the PASCAL VOC dataset. We show that despite differences in image statistics and tasks in the two datasets, the transferred rep- resentation leads to significantly improved results for object and action classification, outperforming the current state of the art on Pascal VOC 2007 and 2012 datasets. We also show promising results for object and action localization. Deep learning methods such as convolutional neural networks (CNNs) can deliver highly accurate classification results when provided with large enough data sets and respective labels. However, using CNNs along with limited labeled data can be problematic, as this leads to extensive overfitting. In this letter, we propose a novel method by considering a pretrained CNN designed for tackling an entirely different classification problem, namely, the ImageNet challenge, and exploit it to extract an initial set of representations. The derived representations are then transferred into a supervised CNN classifier, along with their class labels, effectively training the system. Through this two-stage framework, we successfully deal with the limited-data problem in an end-to-end processing scheme. Comparative results over the UC Merced Land Use benchmark prove that our method significantly outperforms the previously best stated results, improving the overall accuracy from 83.1 up to 92.4 . Apart from statistical improvements, our method introduces a novel feature fusion algorithm that effectively tackles the large data dimensionality by using a simple and computationally efficient approach.