Preventing early progression of epilepsy and so the severity of seizures requires an effective diagnosis. Epileptic transients indicate the ability to develop seizures but humans overlook such brief events in an electroencephalogram (EEG) what compromises patient treatment. Traditionally, training of the EEG event detection algorithms has relied on ground truth labels, obtained from the consensus of the majority of labelers. In this work, we go beyond labeler consensus on EEG data. Our event descriptor integrates EEG signal features with one-hot encoded labeler category that is a key to improved generalization performance. Notably, boosted decision trees take advantage of singly-labeled but more varied training sets. Our quantitative experiments show the proposed labeler-hot epileptic event detector consistently outperforms a consensus-trained detector and maintains confidence bounds of the detection. The results on our infant EEG recordings suggest datasets can gain higher event variety faster and thus better performance by shifting available human effort from consensus-oriented to separate labeling when labels include both, the event and the labeler category.
Detection of epileptiform EEG discharges has been addressed before as well. Detection has usually used time domain features (e.g. amplitude, duration, curvature sharpness, complication, fractal dimension, sample entropy), frequency domain features (e.g. spectral power density, Hjorth's parameters, phase congruence) or wavelet domain features (e.g. wavelet coefficients). Different classification algorithms ware applied: SVM, logistic regression, boosted trees, random forests. There were also experiments with clustering and anomaly detection methods and dynamic time warping. For comprehensive review see @cite_19 @cite_20 . Spike detection brought attention in deep learning community @cite_4 . Commercial implementations also exist @cite_14 .
@cite_19 @cite_14 @cite_4 @cite_20
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A novel wavelet-based algorithm for real-time detection of epileptic seizures using scalp EEG is proposed. In a moving-window analysis, the EEG from each channel is decomposed by wavelet packet transform. Using wavelet coefficients from seizure and nonseizure references, a patient-specific measure is developed to quantify the separation between seizure and nonseizure states for the frequency range of 1-30 Hz. Utilizing this measure, a frequency band representing the maximum separation between the two states is determined and employed to develop a normalized index, called combined seizure index (CSI). CSI is derived for each epoch of every EEG channel based on both rhythmicity and relative energy of that epoch as well as consistency among different channels. Increasing significantly during ictal states, CSI is inspected using one-sided cumulative sum test to generate proper channel alarms. Analyzing alarms from all channels, a seizure alarm is finally generated. The algorithm was tested on scalp EEG recordings from 14 patients, totaling 75.8 h with 63 seizures. Results revealed a high sensitivity of 90.5 , a false detection rate of 0.51 h-1 and a median detection delay of 7 s. The algorithm could also lateralize the focus side for patients with temporal lobe epilepsy. Objective: Synchronization phenomena of epileptic electroencephalography (EEG) have long been studied. In this study, we aim at investigating the spatial-temporal synchronization pattern in epileptic human brains using the spectral graph theoretic features extracted from scalp EEG and developing an efficient multivariate approach for detecting seizure onsets in real time. Methods: A complex network model is used for representing the recurrence pattern of EEG signals, based on which the temporal synchronization patterns are quantified using the spectral graph theoretic features. Furthermore, a statistical control chart is applied to the extracted features overtime for monitoring the transits from normal to epileptic states in multivariate EEG systems. Results: Our method is tested on 23 patients from CHB-MIT Scalp EEG database. The results show that the graph theoretic feature yields a high sensitivity ( @math 98 ) and low latency ( @math 6 s) on average, and seizure onsets in 18 patients are 100 detected. Conclusion: Our approach validates the increased temporal synchronization in epileptic EEG and achieves a comparable detection performance to previous studies. Significance: We characterize the temporal synchronization patterns of epileptic EEG using spectral network metrics. In addition, we found significant changes in temporal synchronization in epileptic EEG, which enable a patient-specific approach for real-time seizure detection for personalized diagnosis and treatment. In this paper we present the application of ensemble learning to epileptic seizure detection problem. We propose a robust learning framework to mitigate class imbalance in large CHB-MIT (982 hrs) scalp EEG dataset. The algorithm being used is RUSBoost which is a hybrid data sampling and boosting technique designed especially for skewed classes. The data that is being used in this study has severe class imbalance, with average representation of 0.38 of seizure class to that of 99.62 of non-seizure class. The proposed approach shows the power of RUSBoost in terms of robustness and generalization. We compared our method with the most successful Support Vector Machine (SVM) based approach and report competitive results of 97 seizure detection accuracy, mean detection delay of 2.7s and false detection rate of 0.08 seizure hr. We also report fast training times of just under three minutes on average for average training data of 21 hrs. Abstract Epilepsy is a neurological disorder characterized by the presence of recurring seizures. Like many other neurological disorders, epilepsy can be assessed by the electroencephalogram (EEG). The EEG signal is highly non-linear and non-stationary, and hence, it is difficult to characterize and interpret it. However, it is a well-established clinical technique with low associated costs. In this work, we propose a methodology for the automatic detection of normal , pre-ictal , and ictal conditions from recorded EEG signals. Four entropy features namely Approximate Entropy ( ApEn ), Sample Entropy ( SampEn ), Phase Entropy 1 ( S1 ), and Phase Entropy 2 ( S2 ) were extracted from the collected EEG signals. These features were fed to seven different classifiers: Fuzzy Sugeno Classifier (FSC), Support Vector Machine (SVM), K-Nearest Neighbour (KNN), Probabilistic Neural Network (PNN), Decision Tree (DT), Gaussian Mixture Model (GMM), and Naive Bayes Classifier (NBC). Our results show that the Fuzzy classifier was able to differentiate the three classes with a high accuracy of 98.1 . Overall, compared to previous techniques, our proposed strategy is more suitable for diagnosis of epilepsy with higher accuracy.