We proposed a deep learning method for interpretable diabetic retinopathy (DR) detection. The visual-interpretable feature of the proposed method is achieved by adding the regression activation map (RAM) after the global averaging pooling layer of the convolutional networks (CNN). With RAM, the proposed model can localize the discriminative regions of an retina image to show the specific region of interest in terms of its severity level. We believe this advantage of the proposed deep learning model is highly desired for DR detection because in practice, users are not only interested with high prediction performance, but also keen to understand the insights of DR detection and why the adopted learning model works. In the experiments conducted on a large scale of retina image dataset, we show that the proposed CNN model can achieve high performance on DR detection compared with the state-of-the-art while achieving the merits of providing the RAM to highlight the salient regions of the input image.
The most work most related to our method is @cite_3 in which class activation map is proposed to characterize the weighted activation maps after global average pooling or global maximum pooling layer. This idea has recently been generalized to time series analysis to localize the significant regions in the raw data @cite_17 . In this paper, we extend the method @cite_3 from a classification to a regression setting and shed light on DR detection problem.
@cite_3 @cite_17
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In this work, we revisit the global average pooling layer proposed in [13], and shed light on how it explicitly enables the convolutional neural network to have remarkable localization ability despite being trained on image-level labels. While this technique was previously proposed as a means for regularizing training, we find that it actually builds a generic localizable deep representation that can be applied to a variety of tasks. Despite the apparent simplicity of global average pooling, we are able to achieve 37.1 top-5 error for object localization on ILSVRC 2014, which is remarkably close to the 34.2 top-5 error achieved by a fully supervised CNN approach. We demonstrate that our network is able to localize the discriminative image regions on a variety of tasks despite not being trained for them We propose a technique for making Convolutional Neural Network (CNN)-based models more transparent by visualizing input regions that are 'important' for predictions -- or visual explanations. Our approach, called Gradient-weighted Class Activation Mapping (Grad-CAM), uses class-specific gradient information to localize important regions. These localizations are combined with existing pixel-space visualizations to create a novel high-resolution and class-discriminative visualization called Guided Grad-CAM. These methods help better understand CNN-based models, including image captioning and visual question answering (VQA) models. We evaluate our visual explanations by measuring their ability to discriminate between classes, to inspire trust in humans, and their correlation with occlusion maps. Grad-CAM provides a new way to understand CNN-based models. We have released code, an online demo hosted on CloudCV, and a full version of this extended abstract. In this work, we revisit the global average pooling layer proposed in [13], and shed light on how it explicitly enables the convolutional neural network (CNN) to have remarkable localization ability despite being trained on imagelevel labels. While this technique was previously proposed as a means for regularizing training, we find that it actually builds a generic localizable deep representation that exposes the implicit attention of CNNs on an image. Despite the apparent simplicity of global average pooling, we are able to achieve 37.1 top-5 error for object localization on ILSVRC 2014 without training on any bounding box annotation. We demonstrate in a variety of experiments that our network is able to localize the discriminative image regions despite just being trained for solving classification task1. In this paper we evaluate the quality of the activation layers of a convolutional neural network (CNN) for the gen- eration of object proposals. We generate hypotheses in a sliding-window fashion over different activation layers and show that the final convolutional layers can find the object of interest with high recall but poor localization due to the coarseness of the feature maps. Instead, the first layers of the network can better localize the object of interest but with a reduced recall. Based on this observation we design a method for proposing object locations that is based on CNN features and that combines the best of both worlds. We build an inverse cascade that, going from the final to the initial convolutional layers of the CNN, selects the most promising object locations and refines their boxes in a coarse-to-fine manner. The method is efficient, because i) it uses the same features extracted for detection, ii) it aggregates features using integral images, and iii) it avoids a dense evaluation of the proposals due to the inverse coarse-to-fine cascade. The method is also accurate; it outperforms most of the previously proposed object proposals approaches and when plugged into a CNN-based detector produces state-of-the- art detection performance.