Studies have identified various risk factors associated with the onset of stroke in an individual. Data mining techniques have been used to predict the occurrence of stroke based on these factors by using patients' medical records. However, there has been limited use of electronic health records to study the inter-dependency of different risk factors of stroke. In this paper, we perform an analysis of patients' electronic health records to identify the impact of risk factors on stroke prediction. We also provide benchmark performance of the state-of-art machine learning algorithms for predicting stroke using electronic health records.
There are several works in literature that use machine learning techniques on electronic health records to predict the probability of stroke occurrence. @cite_7 identified that there is a direct relationship between the total count of risk factors and the probability of stroke occurrence. A regression approach was recommended to statistically test the association between a risk factor and its effect. Hanifa and Raja @cite_8 achieved an improved accuracy for predicting stroke risk using radial basis function and polynomial functions applied in a non-linear support vector classification model. At the same time, studies have indicated that redundant attributes and or totally irrelevant attributes to a class should be identified and removed before the use of a classification algorithm @cite_2 . Systematic analysis of input features has been performed for modelling the response variable in areas other than healthcare -- color analysis of ground-based sky cloud images @cite_4 , weather recordings for rainfall detection @cite_0 etc.
@cite_4 @cite_7 @cite_8 @cite_0 @cite_2
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Many machine learning and pattern classification methods have been applied to the diagnosis of Alzheimer’s disease (AD) and its prodromal stage, i.e., mild cognitive impairment (MCI). Recently, rather than predicting categorical variables as in classification, several pattern regression methods have also been used to estimate continuous clinical variables from brain images. However, most existing regression methods focus on estimating multiple clinical variables separately and thus cannot utilize the intrinsic useful correlation information among different clinical variables. On the other hand, in those regression methods, only a single modality of data (usually only the structural MRI) is often used, without considering the complementary information that can be provided by different modalities. In this paper, we propose a general methodology, namely Multi-Modal Multi-Task (M3T) learning, to jointly predict multiple variables from multi-modal data. Here, the variables include not only the clinical variables used for regression but also the categorical variable used for classification, with different tasks corresponding to prediction of different variables. Specifically, our method contains two key components, i.e., (1) a multi-task feature selection which selects the common subset of relevant features for multiple variables from each modality, and (2) a multi-modal support vector machine which fuses the above-selected features from all modalities to predict multiple (regression and classification) variables. To validate our method, we perform two sets of experiments on ADNI baseline MRI, FDG-PET, and cerebrospinal fluid (CSF) data from 45 AD patients, 91 MCI patients, and 50 healthy controls (HC). In the first set of experiments, we estimate two clinical variables such as Mini Mental State Examination (MMSE) and Alzheimer’s Disease Assessment Scale - Cognitive Subscale (ADAS-Cog), as well as one categorical variable (with value of ‘AD’, ‘MCI’ or ‘HC’), from the baseline MRI, FDG-PET, and CSF data. In the second set of experiments, we predict the 2-year changes of MMSE and ADAS-Cog scores and also the conversion of MCI to AD from the baseline MRI, FDG-PET, and CSF data. The results on both sets of experiments demonstrate that our proposed M3T learning scheme can achieve better performance on both regression and classification tasks than the conventional learning methods. Health surveillance systems based on online user-generated content often rely on the identification of textual markers that are related to a target disease. Given the high volume of available data, these systems benefit from an automatic feature selection process. This is accomplished either by applying statistical learning techniques, which do not consider the semantic relationship between the selected features and the inference task, or by developing labour-intensive text classifiers. In this paper, we use neural word embeddings, trained on social media content from Twitter, to determine, in an unsupervised manner, how strongly textual features are semantically linked to an underlying health concept. We then refine conventional feature selection methods by a priori operating on textual variables that are sufficiently close to a target concept. Our experiments focus on the supervised learning problem of estimating influenza-like illness rates from Google search queries. A "flu infection" concept is formulated and used to reduce spurious and potentially confounding features that were selected by previously applied approaches. In this way, we also address forms of scepticism regarding the appropriateness of the feature space, alleviating potential cases of overfitting. Ultimately, the proposed hybrid feature selection method creates a more reliable model that, according to our empirical analysis, improves the inference performance (Mean Absolute Error) of linear and nonlinear regressors by 12 and 28.7 , respectively. We aim to produce predictive models that are not only accurate, but are also interpretable to human experts. Our models are decision lists, which consist of a series of if...then... statements (for example, if high blood pressure, then stroke) that discretize a high-dimensional, multivariate feature space into a series of simple, readily interpretable decision statements. We introduce a generative model called Bayesian Rule Lists that yields a posterior distribution over possible decision lists. It employs a novel prior structure to encourage sparsity. Our experiments show that Bayesian Rule Lists has predictive accuracy on par with the current top algorithms for prediction in machine learning. Our method is motivated by recent developments in personalized medicine, and can be used to produce highly accurate and interpretable medical scoring systems. We demonstrate this by producing an alternative to the CHADS2 score, actively used in clinical practice for estimating the risk of stroke in patients that have atrial fibrillation. Our model is as interpretable as CHADS2, but more accurate. Summary Background—Most machine learning approaches only provide a classification for binary responses. However, probabilities are required for risk estimation using individual patient characteristics. It has been shown recently that every statistical learning machine known to be consistent for a nonparametric regression problem is a probability machine that is provably consistent for this estimation problem. Objectives—The aim of this paper is to show how random forests and nearest neighbors can be used for consistent estimation of individual probabilities. Methods—Two random forest algorithms and two nearest neighbor algorithms are described in detail for estimation of individual probabilities. We discuss the consistency of random forests, nearest neighbors and other learning machines in detail. We conduct a simulation study to illustrate the validity of the methods. We exemplify the algorithms by analyzing two well-known data sets on the diagnosis of appendicitis and the diagnosis of diabetes in Pima Indians. Results—Simulations demonstrate the validity of the method. With the real data application, we show the accuracy and practicality of this approach. We provide sample code from R packages in which the probability estimation is already available. This means that all calculations can be performed using existing software. Conclusions—Random forest algorithms as well as nearest neighbor approaches are valid machine learning methods for estimating individual probabilities for binary responses. Freely available implementations are available in R and may be used for applications.