Longitudinal patient data has the potential to improve clinical risk stratification models for disease. However, chronic diseases that progress slowly over time are often heterogeneous in their clinical presentation. Patients may progress through disease stages at varying rates. This leads to pathophysiological misalignment over time, making it difficult to consistently compare patients in a clinically meaningful way. Furthermore, patients present clinically for the first time at different stages of disease. This eliminates the possibility of simply aligning patients based on their initial presentation. Finally, patient data may be sampled at different rates due to differences in schedules or missed visits. To address these challenges, we propose a robust measure of patient similarity based on subsequence alignment. Compared to global alignment techniques that do not account for pathophysiological misalignment, focusing on the most relevant subsequences allows for an accurate measure of similarity between patients. We demonstrate the utility of our approach in settings where longitudinal data, while useful, are limited and lack a clear temporal alignment for comparison. Applied to the task of stratifying patients for risk of progression to probable Alzheimer's Disease, our approach outperforms models that use only snapshot data (AUROC of 0.839 vs. 0.812) and models that use global alignment techniques (AUROC of 0.822). Our results support the hypothesis that patients' trajectories are useful for quantifying inter-patient similarities and that using subsequence matching and can help account for heterogeneity and misalignment in longitudinal data.
Time-series data are often multi-modal, , multiple heterogeneous sources of data exist. While DTW is trivially applicable to these settings, Shokoohi- @cite_19 find that the generalization of DTW to multi-modal time series is sensitive to the distance metric used for multi-modal comparisons. Furthermore, the application of DTW to multi-modal time series is further complicated by block-wise missing in the data. For example, patients in a study may receive an ubiquitous test ( a blood draw) on all visits but a specialized test ( a lumbar puncture) on only every other visit. While several approaches to deal with missing data have been presented before @cite_11 @cite_3 , these approaches do not consider multi-modal time series. In this paper, we specifically deal with the case of block-wise missing data in multi-modal time series.
@cite_19 @cite_3 @cite_11
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In recent years Dynamic Time Warping (DTW) has emerged as the distance measure of choice for virtually all time series data mining applications. For example, virtually all applications that process data from wearable devices use DTW as a core sub-routine. This is the result of significant progress in improving DTW's efficiency, together with multiple empirical studies showing that DTW-based classifiers at least equal (and generally surpass) the accuracy of all their rivals across dozens of datasets. Thus far, most of the research has considered only the one-dimensional case, with practitioners generalizing to the multi-dimensional case in one of two ways, dependent or independent warping. In general, it appears the community believes either that the two ways are equivalent, or that the choice is irrelevant. In this work, we show that this is not the case. The two most commonly used multi-dimensional DTW methods can produce different classifications, and neither one dominates over the other. This seems to suggest that one should learn the best method for a particular application. However, we will show that this is not necessary; a simple, principled rule can be used on a case-by-case basis to predict which of the two methods we should trust at the time of classification. Our method allows us to ensure that classification results are at least as accurate as the better of the two rival methods, and, in many cases, our method is significantly more accurate. We demonstrate our ideas with the most extensive set of multi-dimensional time series classification experiments ever attempted. Dynamic time warping (DTW), which finds the minimum path by providing non-linear alignments between two time series, has been widely used as a distance measure for time series classification and clustering. However, DTW does not account for the relative importance regarding the phase difference between a reference point and a testing point. This may lead to misclassification especially in applications where the shape similarity between two sequences is a major consideration for an accurate recognition. Therefore, we propose a novel distance measure, called a weighted DTW (WDTW), which is a penalty-based DTW. Our approach penalizes points with higher phase difference between a reference point and a testing point in order to prevent minimum distance distortion caused by outliers. The rationale underlying the proposed distance measure is demonstrated with some illustrative examples. A new weight function, called the modified logistic weight function (MLWF), is also proposed to systematically assign weights as a function of the phase difference between a reference point and a testing point. By applying different weights to adjacent points, the proposed algorithm can enhance the detection of similarity between two time series. We show that some popular distance measures such as DTW and Euclidean distance are special cases of our proposed WDTW measure. We extend the proposed idea to other variants of DTW such as derivative dynamic time warping (DDTW) and propose the weighted version of DDTW. We have compared the performances of our proposed procedures with other popular approaches using public data sets available through the UCR Time Series Data Mining Archive for both time series classification and clustering problems. The experimental results indicate that the proposed approaches can achieve improved accuracy for time series classification and clustering problems. In the last decade, Dynamic Time Warping (DTW) has emerged as the distance measure of choice for virtually all time series data mining applications. This is the result of significant progress in improving DTW’s efficiency, and multiple empirical studies showing that DTW-based classifiers at least equal the accuracy of all their rivals across dozens of datasets. Thus far, most of the research has considered only the one-dimensional case, with practitioners generalizing to the multi-dimensional case in one of two ways. In general, it appears the community believes either that the two ways are equivalent, or that the choice is irrelevant. In this work, we show that this is not the case. The two most commonly used multidimensional DTW methods can produce different classifications, and neither one dominates over the other. This seems to suggest that one should learn the best method for a particular application. However, we will show that this is not necessary; a simple, principled rule can be used on a case-by-case basis to predict which of the two methods we should give credence to. Our method allows us to ensure that classification results are at least as accurate as the better of the two rival methods, and in many cases, our method is strictly more accurate. We demonstrate our ideas with the most extensive set of multi-dimensional time series classification experiments ever attempted. Keywords—Dynamic Time Warping; Classification In the research field of time series analysis, dynamic time warping distance (DTW) is a prevalent similarity measure with high precision. However, the computational complexity of DTW is high, which makes it difficult to be applied to the high dimensional time series. An effective solution is to compute DTW on the piecewise representation (PR-DTW), which employs the features of the subsequences of time series for similarity measure. However, the features that most existing piecewise representations focus on are too simple, which capture only one aspect of the fluctuation information of time series, and thus influence the precision of PR-DTW. In order to solve this problem, we propose a novel piecewise representation model, named piecewise statistic approximation (PSA), for supporting the PR-DTW measure. Rather than focusing on a single type of features, PSA extracts multiple statistical features to capture the synthetic fluctuation information for similarity measure. Besides, by taking the weighted Euclidean distance for the subsequence matching in the subroutine, PSA based DTW (PSADTW) can discriminate the expressivities of the multiple features. Comprehensive experiments over 45 real-world datasets empirically demonstrate that, PSA is well suited to support both precise and efficient PR-DTW measure.