The majority of medical documents and electronic health records are in text format that poses a challenge for data processing and finding relevant documents. Looking for ways to automatically retrieve the enormous amount of health and medical knowledge has always been an intriguing topic. Powerful methods have been developed in recent years to make the text processing automatic. One of the popular approaches to retrieve information based on discovering the themes in health and medical corpora is topic modeling; however, this approach still needs new perspectives. In this research, we describe fuzzy latent semantic analysis (FLSA), a novel approach in topic modeling using fuzzy perspective. FLSA can handle health and medical corpora redundancy issue and provides a new method to estimate the number of topics. The quantitative evaluations show that FLSA produces superior performance and features to latent Dirichlet allocation, the most popular topic model.
Fuzzy clustering has used in predicting the response to treatment with citalopram in alcohol dependence @cite_22 , analyzing diabetic neuropathy @cite_29 , detecting early diabetic retinopathy @cite_49 , characterizing stroke subtypes and coexisting causes of ischemic stroke @cite_6 @cite_13 @cite_34 , improving decision-making in radiation therapy @cite_44 , and detecting cancer such as breast cancer @cite_26 . In addition, fuzzy clustering was used to improve ultrasound imaging technique @cite_1 and analyze microarray data @cite_25 .
@cite_26 @cite_22 @cite_29 @cite_1 @cite_6 @cite_44 @cite_49 @cite_34 @cite_13 @cite_25
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Discusses a hybrid fuzzy image-processing system for situation assessment of diabetic retinopathy. The hybrid approach is motivated by the characteristics of the medical data and of the diagnostic decision-making process. The aim of the system is to support the early detection of diabetic retinopathy in a primary-care environment. For this purpose, both internal medicine. (diabetes) and ophthalmology have to be considered. The main input data are ophthalmological parameters, such as visual acuity, status of the anterior segment, status of the fundus, and previous therapies, and diabetological status; i.e., metabolic data. To reduce the huge number of parameters that have to be extracted by the ophthalmologist, image-processing methods for the automatic analysis of fundus photographs have been developed. The extraction is done by a multistage model-based approach. The segmentation results are used as an input to an overall fuzzy system that produces the final decision outcome (situation classes). Abstract Twentieth century medical science has embraced nineteenth century Boolean probability theory based upon two-valued Aristotelian logic. With the later addition of bit-based, von Neumann structured computational architectures, an epistemology based on randomness has led to a bivalent epidemiological methodology that dominates medical decision making. In contrast, fuzzy logic, based on twentieth century multi-valued logic, and computational structures that are content addressed and adaptively modified, has advanced a new scientific paradigm for the twenty-first century. Diseases such as stroke involve multiple concomitant causal factors that are difficult to represent using conventional statistical methods. We tested which paradigm best represented this complex multi-causal clinical phenomenon—stroke. We show that the fuzzy logic paradigm better represented clinical complexity in cerebrovascular disease than current probability theory based methodology. We believe this finding is generalizable to all of clinical science since multiple concomitant causal factors are involved in nearly all known pathological processes. Abstract Understanding the organization of the human brain requires identification of its functional subdivisions. Clustering schemes based on resting-state functional magnetic resonance imaging (fMRI) data are rapidly emerging as non-invasive alternatives to cytoarchitectonic mapping in postmortem brains. Here, we propose a novel spatio-temporal probabilistic parcellation scheme that overcomes major weaknesses of existing approaches by (i) modeling the fMRI time series of a voxel as a von Mises-Fisher distribution, which is widely used for clustering high dimensional data; (ii) modeling the latent cluster labels as a Markov random field, which provides spatial regularization on the cluster labels by penalizing neighboring voxels having different cluster labels; and (iii) introducing a prior on the number of labels, which helps in uncovering the number of clusters automatically from the data. Cluster labels and model parameters are estimated by an iterative expectation maximization procedure wherein, given the data and current estimates of model parameters, the latent cluster labels, are computed using α-expansion, a state of the art graph cut, method. In turn, given the current estimates of cluster labels, model parameters are estimated by maximizing the pseudo log-likelihood. The performance of the proposed method is validated using extensive computer simulations. Using novel stability analysis we examine the sensitivity of our methods to parameter initialization and demonstrate that the method is robust to a wide range of initial parameter values. We demonstrate the application of our methods by parcellating spatially contiguous as well as non-contiguous brain regions at both the individual participant and group levels. Notably, our analyses yield new data on the posterior boundaries of the supplementary motor area and provide new insights into functional organization of the insular cortex. Taken together, our findings suggest that our method is a powerful tool for investigating functional subdivisions in the human brain. Display Omitted Survival prediction of HCC patients is modeled in a real and high complex scenario.Its complexity is due to a small dataset with heterogeneous and missing input data.We propose a new cluster-based oversampling method to overcome these drawbacks.Neural networks and logistic regression are applied in the classification stage.Experimental results show that our method outperforms previous existing approaches. Liver cancer is the sixth most frequently diagnosed cancer and, particularly, Hepatocellular Carcinoma (HCC) represents more than 90 of primary liver cancers. Clinicians assess each patients treatment on the basis of evidence-based medicine, which may not always apply to a specific patient, given the biological variability among individuals. Over the years, and for the particular case of Hepatocellular Carcinoma, some research studies have been developing strategies for assisting clinicians in decision making, using computational methods (e.g. machine learning techniques) to extract knowledge from the clinical data. However, these studies have some limitations that have not yet been addressed: some do not focus entirely on Hepatocellular Carcinoma patients, others have strict application boundaries, and none considers the heterogeneity between patients nor the presence of missing data, a common drawback in healthcare contexts. In this work, a real complex Hepatocellular Carcinoma database composed of heterogeneous clinical features is studied. We propose a new cluster-based oversampling approach robust to small and imbalanced datasets, which accounts for the heterogeneity of patients with Hepatocellular Carcinoma. The preprocessing procedures of this work are based on data imputation considering appropriate distance metrics for both heterogeneous and missing data (HEOM) and clustering studies to assess the underlying patient groups in the studied dataset (K-means). The final approach is applied in order to diminish the impact of underlying patient profiles with reduced sizes on survival prediction. It is based on K-means clustering and the SMOTE algorithm to build a representative dataset and use it as training example for different machine learning procedures (logistic regression and neural networks). The results are evaluated in terms of survival prediction and compared across baseline approaches that do not consider clustering and or oversampling using the Friedman rank test. Our proposed methodology coupled with neural networks outperformed all others, suggesting an improvement over the classical approaches currently used in Hepatocellular Carcinoma prediction models.