Ability to quantify and predict progression of a disease is fundamental for selecting an appropriate treatment. Many clinical metrics cannot be acquired frequently either because of their cost (e.g. MRI, gait analysis) or because they are inconvenient or harmful to a patient (e.g. biopsy, x-ray). In such scenarios, in order to estimate individual trajectories of disease progression, it is advantageous to leverage similarities between patients, i.e. the covariance of trajectories, and find a latent representation of progression. Most of existing methods for estimating trajectories do not account for events in-between observations, what dramatically decreases their adequacy for clinical practice. In this study, we develop a machine learning framework named Coordinatewise-Soft-Impute (CSI) for analyzing disease progression from sparse observations in the presence of confounding events. CSI is guaranteed to converge to the global minimum of the corresponding optimization problem. Experimental results also demonstrates the effectiveness of CSI using both simulated and real dataset.
In mixed-effect models, every trajectory @math is assumed to be composed of two parts: the @math for some @math that remains the same among all patients and a @math that differs for each @math . In its simplest form, we assume where @math is the @math covariance matrix, @math is the standard deviation and @math , @math are functions @math and @math evaluated at the times @math , respectively. Estimations of model parameters @math can be made via expectation maximization (EM) algorithm @cite_1 . Individual coefficients @math can be estimated using the best unbiased linear predictor (BLUP) @cite_4 .
@cite_1 @cite_4
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In this paper, a novel algorithm to blindly separate an instantaneous linear underdetermined mixture of nonstationary sources is proposed. It means that the number of sources exceeds the number of channels of the available data. The separation is based on the working assumption that the sources are piecewise stationary with a different variance in each block. It proceeds in two steps: 1) estimating the mixing matrix, and 2) computing the optimum beamformer in each block to maximize the signal-to-interference ratio of each separated signal with respect to the remaining signals. Estimating the mixing matrix is accomplished through a specialized tensor decomposition of the set of sample covariance matrices of the received mixture in each block. It utilizes optimum weighting, which allows statistically efficient (CRB attaining) estimation provided that the data obey the assumed Gaussian piecewise stationary model. In simulations, performance of the algorithm is successfully tested on blind separation of 16 speech signals from nine linear instantaneous mixtures of these signals. Given @math noisy samples with @math dimensions, where @math , we show that the multi-step thresholding procedure based on the Lasso -- we call it the Thresholded Lasso , can accurately estimate a sparse vector @math in a linear model @math , where @math is a design matrix normalized to have column @math norm @math , and @math . We show that under the restricted eigenvalue (RE) condition (Bickel-Ritov-Tsybakov 09), it is possible to achieve the @math loss within a logarithmic factor of the ideal mean square error one would achieve with an oracle while selecting a sufficiently sparse model -- hence achieving sparse oracle inequalities ; the oracle would supply perfect information about which coordinates are non-zero and which are above the noise level. In some sense, the Thresholded Lasso recovers the choices that would have been made by the @math penalized least squares estimators, in that it selects a sufficiently sparse model without sacrificing the accuracy in estimating @math and in predicting @math . We also show for the Gauss-Dantzig selector (Cand e s-Tao 07), if @math obeys a uniform uncertainty principle and if the true parameter is sufficiently sparse, one will achieve the sparse oracle inequalities as above, while allowing at most @math irrelevant variables in the model in the worst case, where @math is the smallest integer such that for @math , @math . Our simulation results on the Thresholded Lasso match our theoretical analysis excellently. We introduce the framework of blind regression motivated by matrix completion for recommendation systems: given @math users, @math movies, and a subset of user-movie ratings, the goal is to predict the unobserved user-movie ratings given the data, i.e., to complete the partially observed matrix. Following the framework of non-parametric statistics, we posit that user @math and movie @math have features @math and @math respectively, and their corresponding rating @math is a noisy measurement of @math for some unknown function @math . In contrast with classical regression, the features @math are not observed, making it challenging to apply standard regression methods to predict the unobserved ratings. Inspired by the classical Taylor's expansion for differentiable functions, we provide a prediction algorithm that is consistent for all Lipschitz functions. In fact, the analysis through our framework naturally leads to a variant of collaborative filtering, shedding insight into the widespread success of collaborative filtering in practice. Assuming each entry is sampled independently with probability at least @math with @math , we prove that the expected fraction of our estimates with error greater than @math is less than @math plus a polynomially decaying term, where @math is the variance of the additive entry-wise noise term. Experiments with the MovieLens and Netflix datasets suggest that our algorithm provides principled improvements over basic collaborative filtering and is competitive with matrix factorization methods. We consider linear regression in the high-dimensional regime where the number of observations @math is smaller than the number of parameters @math . A very successful approach in this setting uses @math -penalized least squares (a.k.a. the Lasso) to search for a subset of @math parameters that best explain the data, while setting the other parameters to zero. Considerable amount of work has been devoted to characterizing the estimation and model selection problems within this approach. In this paper we consider instead the fundamental, but far less understood, question of . More precisely, we address the problem of computing p-values for single regression coefficients. On one hand, we develop a general upper bound on the minimax power of tests with a given significance level. On the other, we prove that this upper bound is (nearly) achievable through a practical procedure in the case of random design matrices with independent entries. Our approach is based on a debiasing of the Lasso estimator. The analysis builds on a rigorous characterization of the asymptotic distribution of the Lasso estimator and its debiased version. Our result holds for optimal sample size, i.e., when @math is at least on the order of @math . We generalize our approach to random design matrices with i.i.d. Gaussian rows @math . In this case we prove that a similar distributional characterization (termed standard distributional limit') holds for @math much larger than @math . Finally, we show that for optimal sample size, @math being at least of order @math , the standard distributional limit for general Gaussian designs can be derived from the replica heuristics in statistical physics.