Consider the following three important problems in statistical inference, namely, constructing confidence intervals for (1) the error of a high-dimensional ( @math ) regression estimator, (2) the linear regression noise level, and (3) the genetic signal-to-noise ratio of a continuous-valued trait (related to the heritability). All three problems turn out to be closely related to the little-studied problem of performing inference on the @math -norm of the signal in high-dimensional linear regression. We derive a novel procedure for this, which is asymptotically correct when the covariates are multivariate Gaussian and produces valid confidence intervals in finite samples as well. The procedure, called EigenPrism, is computationally fast and makes no assumptions on coefficient sparsity or knowledge of the noise level. We investigate the width of the EigenPrism confidence intervals, including a comparison with a Bayesian setting in which our interval is just 5 wider than the Bayes credible interval. We are then able to unify the three aforementioned problems by showing that the EigenPrism procedure with only minor modifications is able to make important contributions to all three. We also investigate the robustness of coverage and find that the method applies in practice and in finite samples much more widely than just the case of multivariate Gaussian covariates. Finally, we apply EigenPrism to a genetic dataset to estimate the genetic signal-to-noise ratio for a number of continuous phenotypes.
There has also been a lot of recent interest in estimating the noise level @math in high-dimensional regression problems. @cite_19 introduced a refitted cross validation method that estimates @math assuming sparsity and a model selection procedure that misses none of the correct variables. @cite_12 introduced the scaled Lasso for estimating @math using an iterative procedure that includes the Lasso. @cite_20 also use an @math penalty to estimate the noise level, but in a finite mixture of regressions model. @cite_18 use the Lasso and Stein's unbiased risk estimate to produce an estimator for @math . All of these works prove consistency of their estimators, but under conditions on the sparsity of the coefficient vector. Indeed, it can be shown that such a condition is needed when @math is treated as fixed (which it is not in the present paper). Under the same sparsity conditions, @cite_19 and @cite_12 also provide asymptotic distributional results for their estimators, allowing for the construction of asymptotic CIs. What distinguishes our treatment of this problem from the existing literature is that our estimator and CI for @math make assumptions on the sparsity or structure of @math .
@cite_19 @cite_18 @cite_20 @cite_12
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The problem of consistently estimating the sparsity pattern of a vector β* ∈ RP based on observations contaminated by noise arises in various contexts, including signal denoising, sparse approximation, compressed sensing, and model selection. We analyze the behavior of l1-constrained quadratic programming (QP), also referred to as the Lasso, for recovering the sparsity pattern. Our main result is to establish precise conditions on the problern dimension p, the number k of nonzero elements in β*, and the number of observations n that are necessary and sufficient for sparsity pattern recovery using the Lasso. We first analyze the case of observations made using deterministic design matrices and sub-Gaussian additive noise, and provide sufficient conditions for support recovery and l∞-error bounds, as well as results showing the necessity of incoherence and bounds on the minimum value. We then turn to the case of random designs, in which each row of the design is drawn from a N(0, Σ) ensemble. For a broad class of Gaussian ensembles satisfying mutual incoherence conditions, we compute explicit values of thresholds 0 0, if n > 2(θu + δ)k log(p - k), then the Lasso succeeds in recovering the sparsity pattern with probability converging to one for large problems, whereas for n < 2(θl - δ)k log(p - k), then the probability of successful recovery converges to zero. For the special case of the uniform Gaussian ensemble (Σ = I p×p), we show that θl = θu = 1, so that the precise threshold n = 2k log (p - k) is exactly determined. We consider the problem of fitting the parameters of a high-dimensional linear regression model. In the regime where the number of parameters @math is comparable to or exceeds the sample size @math , a successful approach uses an @math -penalized least squares estimator, known as Lasso. Unfortunately, unlike for linear estimators (e.g., ordinary least squares), no well-established method exists to compute confidence intervals or p-values on the basis of the Lasso estimator. Very recently, a line of work javanmard2013hypothesis, confidenceJM, GBR-hypothesis has addressed this problem by constructing a debiased version of the Lasso estimator. In this paper, we study this approach for random design model, under the assumption that a good estimator exists for the precision matrix of the design. Our analysis improves over the state of the art in that it establishes nearly optimal testing power if the sample size @math asymptotically dominates @math , with @math being the sparsity level (number of non-zero coefficients). Earlier work obtains provable guarantees only for much larger sample size, namely it requires @math to asymptotically dominate @math . In particular, for random designs with a sparse precision matrix we show that an estimator thereof having the required properties can be computed efficiently. Finally, we evaluate this approach on synthetic data and compare it with earlier proposals. We consider the problem of estimating an unknown signal @math from noisy linear observations @math . In many practical instances, @math has a certain structure that can be captured by a structure inducing convex function @math . For example, @math norm can be used to encourage a sparse solution. To estimate @math with the aid of @math , we consider the well-known LASSO method and provide sharp characterization of its performance. We assume the entries of the measurement matrix @math and the noise vector @math have zero-mean normal distributions with variances @math and @math respectively. For the LASSO estimator @math , we attempt to calculate the Normalized Square Error (NSE) defined as @math as a function of the noise level @math , the number of observations @math and the structure of the signal. We show that, the structure of the signal @math and choice of the function @math enter the error formulae through the summary parameters @math and @math , which are defined as the Gaussian squared-distances to the subdifferential cone and to the @math -scaled subdifferential, respectively. The first LASSO estimator assumes a-priori knowledge of @math and is given by @math . We prove that its worst case NSE is achieved when @math and concentrates around @math . Secondly, we consider @math , for some @math . This time the NSE formula depends on the choice of @math and is given by @math . We then establish a mapping between this and the third estimator @math . Finally, for a number of important structured signal classes, we translate our abstract formulae to closed-form upper bounds on the NSE. Scaled sparse linear regression jointly estimates the regression coefficients and noise level in a linear model. It chooses an equilibrium with a sparse regression method by iteratively estimating the noise level via the mean residual square and scaling the penalty in proportion to the estimated noise level. The iterative algorithm costs little beyond the computation of a path or grid of the sparse regression estimator for penalty levels above a proper threshold. For the scaled lasso, the algorithm is a gradient descent in a convex minimization of a penalized joint loss function for the regression coefficients and noise level. Under mild regularity conditions, we prove that the scaled lasso simultaneously yields an estimator for the noise level and an estimated coefficient vector satisfying certain oracle inequalities for prediction, the estimation of the noise level and the regression coefficients. These inequalities provide sufficient conditions for the consistency and asymptotic normality of the noise-level estimator, including certain cases where the number of variables is of greater order than the sample size. Parallel results are provided for least-squares estimation after model selection by the scaled lasso. Numerical results demonstrate the superior performance of the proposed methods over an earlier proposal of joint convex minimization. Copyright 2012, Oxford University Press.