In this paper, we develop a new weakly supervised learning algorithm to learn to segment cancerous regions in histopathology images. This paper is under a multiple instance learning (MIL) framework with a new formulation, deep weak supervision (DWS); we also propose an effective way to introduce constraints to our neural networks to assist the learning process. The contributions of our algorithm are threefold: 1) we build an end-to-end learning system that segments cancerous regions with fully convolutional networks (FCNs) in which image-to-image weakly-supervised learning is performed; 2) we develop a DWS formulation to exploit multi-scale learning under weak supervision within FCNs; and 3) constraints about positive instances are introduced in our approach to effectively explore additional weakly supervised information that is easy to obtain and enjoy a significant boost to the learning process. The proposed algorithm, abbreviated as DWS-MIL, is easy to implement and can be trained efficiently. Our system demonstrates the state-of-the-art results on large-scale histopathology image data sets and can be applied to various applications in medical imaging beyond histopathology images, such as MRI, CT, and ultrasound images.
Holistically-nested edge detector (HED) is developed in @cite_38 by combining deep supervision with fully convolutional networks to effectively learn edges and object boundaries. Our deep weak supervision formulation is inspired by HED but we instead focus on a weakly-supervised learning setting as opposed to being fully supervised in HED. Our deep weak supervision demonstrates its power under an end-to-end MIL framework.
@cite_38
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We develop a new edge detection algorithm that tackles two important issues in this long-standing vision problem: (1) holistic image training and prediction; and (2) multi-scale and multi-level feature learning. Our proposed method, holistically-nested edge detection (HED), performs image-to-image prediction by means of a deep learning model that leverages fully convolutional neural networks and deeply-supervised nets. HED automatically learns rich hierarchical representations (guided by deep supervision on side responses) that are important in order to approach the human ability resolve the challenging ambiguity in edge and object boundary detection. We significantly advance the state-of-the-art on the BSD500 dataset (ODS F-score of .782) and the NYU Depth dataset (ODS F-score of .746), and do so with an improved speed (0.4 second per image) that is orders of magnitude faster than some recent CNN-based edge detection algorithms. Wepropose using relaxed deep supervision (RDS) within convolutional neural networks for edge detection. The conventional deep supervision utilizes the general groundtruth to guide intermediate predictions. Instead, we build hierarchical supervisory signals with additional relaxed labels to consider the diversities in deep neural networks. We begin by capturing the relaxed labels from simple detectors (e.g. Canny). Then we merge them with the general groundtruth to generate the RDS. Finally we employ the RDS to supervise the edge network following a coarse-to-fine paradigm. These relaxed labels can be seen as some false positives that are difficult to be classified. Weconsider these false positives in the supervision, and are able to achieve high performance for better edge detection. Wecompensate for the lack of training images by capturing coarse edge annotations from a large dataset of image segmentations to pretrain the model. Extensive experiments demonstrate that our approach achieves state-of-the-art performance on the well-known BSDS500 dataset (ODS F-score of .792) and obtains superior cross-dataset generalization results on NYUD dataset. Data-driven approaches for edge detection have proven effective and achieve top results on modern benchmarks. However, all current data-driven edge detectors require manual supervision for training in the form of hand-labeled region segments or object boundaries. Specifically, human annotators mark semantically meaningful edges which are subsequently used for training. Is this form of strong, highlevel supervision actually necessary to learn to accurately detect edges? In this work we present a simple yet effective approach for training edge detectors without human supervision. To this end we utilize motion, and more specifically, the only input to our method is noisy semi-dense matches between frames. We begin with only a rudimentary knowledge of edges (in the form of image gradients), and alternate between improving motion estimation and edge detection in turn. Using a large corpus of video data, we show that edge detectors trained using our unsupervised scheme approach the performance of the same methods trained with full supervision (within 3-5 ). Finally, we show that when using a deep network for the edge detector, our approach provides a novel pre-training scheme for object detection. Weakly supervised object detection has attracted extensive research efforts in recent years. Without the need of annotating bounding boxes, the existing methods usually follow a two multi-stage pipeline with an online compulsive stage to extract object proposals, which is an order of magnitude slower than fast fully supervised object detectors such as SSD [31] and YOLO [34]. In this paper, we speedup online weakly supervised object detectors by orders of magnitude by proposing a novel generative adversarial learning paradigm. In the proposed paradigm, the generator is a one-stage object detector to generate bounding boxes from images. To guide the learning of object-level generator, a surrogator is introduced to mine high-quality bounding boxes for training. We further adapt a structural similarity loss in combination with an adversarial loss into the training objective, which solves the challenge that the bounding boxes produced by the surrogator may not well capture their ground truth. Our one-stage detector outperforms all existing schemes in terms of detection accuracy, running at 118 frames per second, which is up to 438A— faster than the state-of-the-art weakly supervised detectors [8, 30, 15, 27, 45]. The code will be available publicly soon.