Signet ring cell carcinoma is a type of rare adenocarcinoma with poor prognosis. Early detection leads to huge improvement of patients’ survival rate. However, pathologists can only visually detect signet ring cells under the microscope. This procedure is not only laborious but also prone to omission. An automatic and accurate signet ring cell detection solution is thus important but has not been investigated before. In this paper, we take the first step to present a semi-supervised learning framework for the signet ring cell detection problem. Self-training is proposed to deal with the challenge of incomplete annotations, and cooperative-training is adapted to explore the unlabeled regions. Combining the two techniques, our semi-supervised learning framework can make better use of both labeled and unlabeled data. Experiments on large real clinical data demonstrate the effectiveness of our design. Our framework achieves accurate signet ring cell detection and can be readily applied in the clinical trails. The dataset will be released soon to facilitate the development of the area.
Several semi-supervised learning methods have been proposed and verified their effectiveness on natural images @cite_13 @cite_5 @cite_9 @cite_4 @cite_16 @cite_0 . @cite_4 used box-level annotation to achieve similar performance with pixel-level annotation. @cite_9 organized a reconstruction head to convert segmentation output back to original images. Generally, all the previous methods focus on training one model with complex auxiliary branches. On the contrary, our semi-supervised learning framework can organize the multiple models to support each other and no extra auxiliary branch is needed. There have been lots of automatic methods for pathology, including nuclei segmentation @cite_12 @cite_8 @cite_18 and specific object @cite_10 . However, automatic signet ring cell detection has not been investigated before to our best knowledge.
@cite_18 @cite_4 @cite_8 @cite_10 @cite_9 @cite_0 @cite_5 @cite_16 @cite_13 @cite_12
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Supervised contour detection methods usually require many labeled training images to obtain satisfactory performance. However, a large set of annotated data might be unavailable or extremely labor intensive. In this paper, we investigate the usage of semi-supervised learning (SSL) to obtain competitive detection accuracy with very limited training data (three labeled images). Specifically, we propose a semi-supervised structured ensemble learning approach for contour detection built on structured random forests (SRF). To allow SRF to be applicable to unlabeled data, we present an effective sparse representation approach to capture inherent structure in image patches by finding a compact and discriminative low-dimensional subspace representation in an unsupervised manner, enabling the incorporation of abundant unlabeled patches with their estimated structured labels to help SRF perform better node splitting. We re-examine the role of sparsity and propose a novel and fast sparse coding algorithm to boost the overall learning efficiency. To the best of our knowledge, this is the first attempt to apply SSL for contour detection. Extensive experiments on the BSDS500 segmentation dataset and the NYU Depth dataset demonstrate the superiority of the proposed method. Supervised object detection and semantic segmentation require object or even pixel level annotations. When there exist image level labels only, it is challenging for weakly supervised algorithms to achieve accurate predictions. The accuracy achieved by top weakly supervised algorithms is still significantly lower than their fully supervised counterparts. In this paper, we propose a novel weakly supervised curriculum learning pipeline for multi-label object recognition, detection and semantic segmentation. In this pipeline, we first obtain intermediate object localization and pixel labeling results for the training images, and then use such results to train task-specific deep networks in a fully supervised manner. The entire process consists of four stages, including object localization in the training images, filtering and fusing object instances, pixel labeling for the training images, and task-specific network training. To obtain clean object instances in the training images, we propose a novel algorithm for filtering, fusing and classifying object instances collected from multiple solution mechanisms. In this algorithm, we incorporate both metric learning and density-based clustering to filter detected object instances. Experiments show that our weakly supervised pipeline achieves state-of-the-art results in multi-label image classification as well as weakly supervised object detection and very competitive results in weakly supervised semantic segmentation on MS-COCO, PASCAL VOC 2007 and PASCAL VOC 2012. We present an adversarial domain adaptation based deep learning approach for automatic tumor segmentation from T2-weighted MRI. Our approach is composed of two steps: (i) a tumor-aware unsupervised cross-domain adaptation (CT to MRI), followed by (ii) semi-supervised tumor segmentation using Unet trained with synthesized and limited number of original MRIs. We introduced a novel target specific loss, called tumor-aware loss, for unsupervised cross-domain adaptation that helps to preserve tumors on synthesized MRIs produced from CT images. In comparison, state-of-the art adversarial networks trained without our tumor-aware loss produced MRIs with ill-preserved or missing tumors. All networks were trained using labeled CT images from 377 patients with non-small cell lung cancer obtained from the Cancer Imaging Archive and unlabeled T2w MRIs from a completely unrelated cohort of 6 patients with pre-treatment and 36 on-treatment scans. Next, we combined 6 labeled pre-treatment MRI scans with the synthesized MRIs to boost tumor segmentation accuracy through semi-supervised learning. Semi-supervised training of cycle-GAN produced a segmentation accuracy of 0.66 computed using Dice Score Coefficient (DSC). Our method trained with only synthesized MRIs produced an accuracy of 0.74 while the same method trained in semi-supervised setting produced the best accuracy of 0.80 on test. Our results show that tumor-aware adversarial domain adaptation helps to achieve reasonably accurate cancer segmentation from limited MRI data by leveraging large CT datasets. Fully convolutional networks (FCN) have achieved great success in human parsing in recent years. In conventional human parsing tasks, pixel-level labeling is required for guiding the training, which usually involves enormous human labeling efforts. To ease the labeling efforts, we propose a novel weakly supervised human parsing method which only requires simple object keypoint annotations for learning. We develop an iterative learning method to generate pseudo part segmentation masks from keypoint labels. With these pseudo masks, we train an FCN network to output pixel-level human parsing predictions. Furthermore, we develop a correlation network to perform joint prediction of part and object segmentation masks and improve the segmentation performance. The experiment results show that our weakly supervised method is able to achieve very competitive human parsing results. Despite our method only uses simple keypoint annotations for learning, we are able to achieve comparable performance with fully supervised methods which use the expensive pixel-level annotations.