This paper has been withdrawn by the authors due to insufficient or definition error(s) in the ethics approval protocol. Autism spectrum disorders (ASD) impact the cognitive, social, communicative and behavioral abilities of an individual. The development of new clinical decision support systems is of importance in reducing the delay between presentation of symptoms and an accurate diagnosis. In this work, we contribute a new database consisting of video clips of typical (normal) and atypical (such as hand flapping, spinning or rocking) behaviors, displayed in natural settings, which have been collected from the YouTube video website. We propose a preliminary non-intrusive approach based on skeleton keypoint identification using pretrained deep neural networks on human body video clips to extract features and perform body movement analysis that differentiates typical and atypical behaviors of children. Experimental results on the newly contributed database show that our platform performs best with decision tree as the classifier when compared to other popular methodologies and offers a baseline against which alternate approaches may developed and tested.
Recently Dawson in @cite_21 reported differences in motor function are an early feature of ASD. They explored midline head and body posture control by detecting facial landmarks and head pose angles of children. Their finding shows that toddlers with ASD exhibited significant higher rate of head movement as compared to non-ASD toddlers, suggesting difficulties in balancing midline head position while engaging attentional systems.
@cite_21
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Evidence suggests that differences in motor function are an early feature of autism spectrum disorder (ASD). One aspect of motor ability that develops during childhood is postural control, reflected in the ability to maintain a steady head and body position without excessive sway. Observational studies have documented differences in postural control in older children with ASD. The present study used computer vision analysis to assess midline head postural control, as reflected in the rate of spontaneous head movements during states of active attention, in 104 toddlers between 16–31 months of age (Mean = 22 months), 22 of whom were diagnosed with ASD. Time-series data revealed robust group differences in the rate of head movements while the toddlers watched movies depicting social and nonsocial stimuli. Toddlers with ASD exhibited a significantly higher rate of head movement as compared to non-ASD toddlers, suggesting difficulties in maintaining midline position of the head while engaging attentional systems. The use of digital phenotyping approaches, such as computer vision analysis, to quantify variation in early motor behaviors will allow for more precise, objective, and quantitative characterization of early motor signatures and potentially provide new automated methods for early autism risk identification. In this paper, we propose a “Response to Name Dataset” for autism spectrum disorder (ASD) study as well as a multimodal ASD auxiliary screening system based on machine learning. ASD children are characterized by their impaired interpersonal communication abilities and lack of response. In the proposed dataset, the reactions of children are recorded by cameras upon calling their names. The responsiveness of each child is then evaluated by a clinician with a score among 0, 1 and 2 following the Autism Diagnostic Observation Schedule (ADOS). We then develop a rule-based multimodal framework to quantitatively evaluate each child. Our system involves speech recognition based automatic name calling detection, face detection alignment, head pose estimation, and considers the response speed, eye contact duration and head orientation to output the final prediction. Compared to existing work, our dataset characterizes a more precise and detailed scoring system with clinical trial standards, as well as a more spontaneous setting by incorporating less lab-controlled sessions with dynamic cluttered environments, multi-pose mobile captured videos, and flexible number of accompanying adults. Experiments show that our machine predicted scores align closely with human professional diagnosis, showing promising potential in early screening of ASD, and shedding light on future clinical applications. Autism spectrum disorder (ASD) is a neurodevelopmental disability with atypical traits in behavioral and physiological responses. These atypical traits in individuals with ASD may be too subtle and subjective to measure visually using tedious methods of scoring. Alternatively, the use of intrusive sensors in the measurement of psychophysical responses in individuals with ASD may likely cause inhibition and bias. This paper proposes a novel experimental protocol for non-intrusive sensing and analysis of facial expression, visual scanning, and eye-hand coordination to investigate behavioral markers for ASD. An institutional review board approved pilot study is conducted to collect the response data from two groups of subjects (ASD and control) while they engage in the tasks of visualization, recognition, and manipulation. For the first time in the ASD literature, the facial action coding system is used to classify spontaneous facial responses. Statistical analyses reveal significantly (p <0.01) higher prevalence of smile expression for the group with ASD with the eye-gaze significantly averted (p<0.05) from viewing the face in the visual stimuli. This uncontrolled manifestation of smile without proper visual engagement suggests impairment in reciprocal social communication, e.g., social smile. The group with ASD also reveals poor correlation in eye-gaze and hand movement data suggesting deficits in motor coordination while performing a dynamic manipulation task. The simultaneous sensing and analysis of multimodal response data may provide useful quantitative insights into ASD to facilitate early detection of symptoms for effective intervention planning. Children with autism spectrum condition (ASC) suffer from deficits or developmental delays in symbolic thinking. In particular, they are often found lacking in pretend play during early childhood. Researchers believe that they encounter difficulty in generating and maintaining mental representation of pretense coupled with the immediate reality. We have developed an interactive system that explores the potential of Augmented Reality (AR) technology to visually conceptualize the representation of pretense within an open-ended play environment. Results from an empirical study involving children with ASC aged 4 to 7 demonstrated a significant improvement of pretend play in terms of frequency, duration and relevance using the AR system in comparison to a non computer-assisted situation. We investigated individual differences, skill transfer, system usability and limitations of the proposed AR system. We discuss design guidelines for future AR systems for children with ASC and other pervasive developmental disorders.