Low-dose computed tomography (LDCT) has offered tremendous benefits in radiation-restricted applications, but the quantum noise as resulted by the insufficient number of photons could potentially harm the diagnostic performance. Current image-based denoising methods tend to produce a blur effect on the final reconstructed results especially in high noise levels. In this paper, a deep learning-based approach was proposed to mitigate this problem. An adversarially trained network and a sharpness detection network were trained to guide the training process. Experiments on both simulated and real dataset show that the results of the proposed method have very small resolution loss and achieves better performance relative to state-of-the-art methods both quantitatively and visually.
Convolutional neural network (CNN) based methods have recently achieved great success in image related tasks. Although its origins can be traced back to the 1980s, the resurgence of CNN can be greatly attributed to increased computational power and recently introduced techniques for efficient training of deep networks, such as BatchNorm @cite_26 , Rectifier linear units @cite_57 and residual connection @cite_47 . @cite_15 first used CNN to denoise CT images by learning a patch-based neural net and later on refined it with a encoder and decoder structure for end-to-end training @cite_14 . @cite_44 devised a 24 convolution layer net with by-pass connection and contracting path for denoising but instead of mapping in the image domain, it performed end-to-end training in the wavelet domain. @cite_18 adopted perceptual loss into the training, which measures the difference of the processed image and the ground truth in a high level feature space projected by a pre-trained CNN. @cite_32 proposed to use a massive-training artificial neural network (MTANN) for CT denoising. The network accepts local patches of the LDCT and regressed to the center value of the corresponding patch of the convCT.
@cite_18 @cite_14 @cite_26 @cite_15 @cite_32 @cite_57 @cite_44 @cite_47
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Convolutional neural network (CNN) has achieved the state-of-the-art performance in many different visual tasks. Learned from a large-scale training data set, CNN features are much more discriminative and accurate than the handcrafted features. Moreover, CNN features are also transferable among different domains. On the other hand, traditional dictionary-based features (such as BoW and spatial pyramid matching) contain much more local discriminative and structural information, which is implicitly embedded in the images. To further improve the performance, in this paper, we propose to combine CNN with dictionary-based models for scene recognition and visual domain adaptation (DA). Specifically, based on the well-tuned CNN models (e.g., AlexNet and VGG Net), two dictionary-based representations are further constructed, namely, mid-level local representation (MLR) and convolutional Fisher vector (CFV) representation. In MLR, an efficient two-stage clustering method, i.e., weighted spatial and feature space spectral clustering on the parts of a single image followed by clustering all representative parts of all images, is used to generate a class-mixture or a class-specific part dictionary. After that, the part dictionary is used to operate with the multiscale image inputs for generating mid-level representation. In CFV, a multiscale and scale-proportional Gaussian mixture model training strategy is utilized to generate Fisher vectors based on the last convolutional layer of CNN. By integrating the complementary information of MLR, CFV, and the CNN features of the fully connected layer, the state-of-the-art performance can be achieved on scene recognition and DA problems. An interested finding is that our proposed hybrid representation (from VGG net trained on ImageNet) is also complementary to GoogLeNet and or VGG-11 (trained on Place205) greatly. Recently, neuron activations extracted from a pre-trained convolutional neural network (CNN) show promising performance in various visual tasks. However, due to the domain and task bias, using the features generated from the model pre-trained for image classification as image representations for instance retrieval is problematic. In this paper, we propose quartet-net learning to improve the discriminative power of CNN features for instance retrieval. The general idea is to map the features into a space where the image similarity can be better evaluated. Our network differs from the traditional Siamese-net in two ways. First, we adopt a double-margin contrastive loss with a dynamic margin tuning strategy to train the network which leads to more robust performance. Second, we introduce in the mimic learning regularization to improve the generalization ability of the network by preventing it from overfitting to the training data. Catering for the network learning, we collect a large-scale dataset, namely GeoPair, which consists of 68k matching image pairs and 63k non-matching pairs. Experiments on several standard instance retrieval datasets demonstrate the effectiveness of our method. Convolutional neural networks (CNNs) have been successfully used for fast and accurate estimation of dense correspondences between images in computer vision applications. However, much of their success is based on the availability of large training datasets with dense ground truth correspondences, which are only rarely available in medical applications. In this paper, we, therefore, address the problem of CNNs learning from few training data for medical image registration. Our contributions are threefold: (1) We present a novel approach for learning highly expressive appearance models from few training samples, (2) we show that this approach can be used to synthesize huge amounts of realistic ground truth training data for CNN-based medical image registration, and (3) we adapt the FlowNet architecture for CNN-based optical flow estimation to the medical image registration problem. This pipeline is applied to two medical data sets with less than 40 training images. We show that CNNs learned from the proposed generative model outperform those trained on random deformations or displacement fields estimated via classical image registration. Learning Convolutional Neural Networks (CNN) is commonly carried out by plain supervised gradient descent. With sufficient training data, this leads to very competitive results for visual recognition tasks when starting from a random initialization. When the amount of labeled data is limited, CNNs reveal their strong dependence on large amounts of training data. However, recent results have shown that a well chosen optimization starting point can be beneficial for convergence to a good generalizing minimum. This starting point was mostly found using unsupervised feature learning techniques such as sparse coding or transfer learning from related recognition tasks. In this work, we compare these two approaches against a simple patch based initialization scheme and a random initialization of the weights. We show that pre-training helps to train CNNs from few samples and that the correct choice of the initialization scheme can push the network's performance by up to 41 compared to random initialization.