Due to the high resolution of pathological images, the automated semantic segmentation in the medical pathological images has shown greater challenges than that in natural images. Sliding Window method has shown its effect on solving problem caused by the high resolution of whole slide images (WSI). However, owing to its localization, Sliding Window method also suffers from lack of global information. In this paper, a dual input semantic segmentation network based on attention is proposed, in which, one input provides small-scale fine information, the other input provides large-scale coarse information. Compared with single input methods, our method based on dual inputs and attention: DA-RefineNet exhibits a dramatic performance improvement on ICIAR2018 breast cancer segmentation task.
In this paper we adopt Refinenet @cite_14 as the baseline. The main difference between Refinenet and Unet @cite_26 lies in the unique block "Refine Block". The Refine Block is a unique feature fusion block, which can be divided into three parts. (1) Residual Convolution Unit (RCU). This is a convolutional module based on the residual connection design. Compared with the original Resnet @cite_6 , the BN layer is removed, and the parameter amount is reduced to be used as a feature extractor. (2) Multi-size fusion. Our task is semantic segmentation, with the output and the input in the same size, the blocks except for Block No.4 being dual input, and the two input in different scales. Thus multi-size fusion is applied for upsampleing and feature fusion. (3) Chain residual pooling(CRP). The module efficiently fuses features through convolution pooling operations of different window sizes. Through this chained pooling operation, the receptive field is expanded. At the same time, multi-scale information is merged through short jump connections, which let gradient go to directly from one module to another.
@cite_14 @cite_6 @cite_26
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Recently, very deep convolutional neural networks (CNNs) have shown outstanding performance in object recognition and have also been the first choice for dense classification problems such as semantic segmentation. However, repeated subsampling operations like pooling or convolution striding in deep CNNs lead to a significant decrease in the initial image resolution. Here, we present RefineNet, a generic multi-path refinement network that explicitly exploits all the information available along the down-sampling process to enable high-resolution prediction using long-range residual connections. In this way, the deeper layers that capture high-level semantic features can be directly refined using fine-grained features from earlier convolutions. The individual components of RefineNet employ residual connections following the identity mapping mindset, which allows for effective end-to-end training. Further, we introduce chained residual pooling, which captures rich background context in an efficient manner. We carry out comprehensive experiments and set new state-of-the-art results on seven public datasets. In particular, we achieve an intersection-over-union score of 83.4 on the challenging PASCAL VOC 2012 dataset, which is the best reported result to date. Recently, very deep convolutional neural networks (CNNs) have shown outstanding performance in object recognition and have also been the first choice for dense classification problems such as semantic segmentation. However, repeated subsampling operations like pooling or convolution striding in deep CNNs lead to a significant decrease in the initial image resolution. Here, we present RefineNet, a generic multi-path refinement network that explicitly exploits all the information available along the down-sampling process to enable high-resolution prediction using long-range residual connections. In this way, the deeper layers that capture high-level semantic features can be directly refined using fine-grained features from earlier convolutions. The individual components of RefineNet employ residual connections following the identity mapping mindset, which allows for effective end-to-end training. Further, we introduce chained residual pooling, which captures rich background context in an efficient manner. We carry out comprehensive experiments and set new state-of-the-art results on seven public datasets. In particular, we achieve an intersection-over-union score of 83.4 on the challenging PASCAL VOC 2012 dataset, which is the best reported result to date. Compared to conventional saliency detection by handcrafted features, deep convolutional neural networks (CNNs) recently have been successfully applied to saliency detection field with superior performance on locating salient objects. However, due to repeated sub-sampling operations inside CNNs such as pooling and convolution, many CNN-based saliency models fail to maintain fine-grained spatial details and boundary structures of objects. To remedy this issue, this paper proposes a novel end-to-end deep learning-based refinement model named Refinet , which is based on fully convolutional network augmented with segmentation hypotheses. Intermediate saliency maps that are edge-aware are computed from segmentation-based pooling and then feed to a two-tier fully convolutional network for effective fusion and refinement, leading to more precise object details and boundaries. In addition, the resolution of feature maps in the proposed Refinet is carefully designed to guarantee sufficient boundary clarity of the refined saliency output. Compared to widely employed dense conditional random field, Refinet is able to enhance coarse saliency maps generated by existing models with more accurate spatial details, and its effectiveness is demonstrated by experimental results on seven benchmark datasets. State-of-the-art semantic segmentation approaches increase the receptive field of their models by using either a downsampling path composed of poolings strided convolutions or successive dilated convolutions. However, it is not clear which operation leads to best results. In this paper, we systematically study the differences introduced by distinct receptive field enlargement methods and their impact on the performance of a novel architecture, called Fully Convolutional DenseResNet (FC-DRN). FC-DRN has a densely connected backbone composed of residual networks. Following standard image segmentation architectures, receptive field enlargement operations that change the representation level are interleaved among residual networks. This allows the model to exploit the benefits of both residual and dense connectivity patterns, namely: gradient flow, iterative refinement of representations, multi-scale feature combination and deep supervision. In order to highlight the potential of our model, we test it on the challenging CamVid urban scene understanding benchmark and make the following observations: 1) downsampling operations outperform dilations when the model is trained from scratch, 2) dilations are useful during the finetuning step of the model, 3) coarser representations require less refinement steps, and 4) ResNets (by model construction) are good regularizers, since they can reduce the model capacity when needed. Finally, we compare our architecture to alternative methods and report state-of-the-art result on the Camvid dataset, with at least twice fewer parameters.