This paper presents a new method for medical diagnosis of neurodegenerative diseases, such as Parkinson's, by extracting and using latent information from trained Deep convolutional, or convolutional-recurrent Neural Networks (DNNs). In particular, our approach adopts a combination of transfer learning, k-means clustering and k-Nearest Neighbour classification of deep neural network learned representations to provide enriched prediction of the disease based on MRI and or DaT Scan data. A new loss function is introduced and used in the training of the DNNs, so as to perform adaptation of the generated learned representations between data from different medical environments. Results are presented using a recently published database of Parkinson's related information, which was generated and evaluated in a hospital environment.
The developed networks included: transfer learning of the ResNet-50 network @cite_20 as far as the convolutional part of the networks was concerned, with retraining of the fully connected network layers; adding on top of this and training a recurrent network using Gated Recurrent Units (GRU) @cite_5 in an end-to-end manner.
@cite_5 @cite_20
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Recurrent neural networks (RNNs) have been widely used for processing sequential data. However, RNNs are commonly difficult to train due to the well-known gradient vanishing and exploding problems and hard to learn long-term patterns. Long short-term memory (LSTM) and gated recurrent unit (GRU) were developed to address these problems, but the use of hyperbolic tangent and the sigmoid action functions results in gradient decay over layers. Consequently, construction of an efficiently trainable deep network is challenging. In addition, all the neurons in an RNN layer are entangled together and their behaviour is hard to interpret. To address these problems, a new type of RNN, referred to as independently recurrent neural network (IndRNN), is proposed in this paper, where neurons in the same layer are independent of each other and they are connected across layers. We have shown that an IndRNN can be easily regulated to prevent the gradient exploding and vanishing problems while allowing the network to learn long-term dependencies. Moreover, an IndRNN can work with non-saturated activation functions such as relu (rectified linear unit) and be still trained robustly. Multiple IndRNNs can be stacked to construct a network that is deeper than the existing RNNs. Experimental results have shown that the proposed IndRNN is able to process very long sequences (over 5000 time steps), can be used to construct very deep networks (21 layers used in the experiment) and still be trained robustly. Better performances have been achieved on various tasks by using IndRNNs compared with the traditional RNN and LSTM. Recurrent Neural Networks (RNNs) with sophisticated units that implement a gating mechanism have emerged as powerful technique for modeling sequential signals such as speech or electroencephalography (EEG). The latter is the focus on this paper. A significant big data resource, known as the TUH EEG Corpus (TUEEG), has recently become available for EEG research, creating a unique opportunity to evaluate these recurrent units on the task of seizure detection. In this study, we compare two types of recurrent units: long short-term memory units (LSTM) and gated recurrent units (GRU). These are evaluated using a state of the art hybrid architecture that integrates Convolutional Neural Networks (CNNs) with RNNs. We also investigate a variety of initialization methods and show that initialization is crucial since poorly initialized networks cannot be trained. Furthermore, we explore regularization of these convolutional gated recurrent networks to address the problem of overfitting. Our experiments revealed that convolutional LSTM networks can achieve significantly better performance than convolutional GRU networks. The convolutional LSTM architecture with proper initialization and regularization delivers 30 sensitivity at 6 false alarms per 24 hours. In existing convolutional neural networks (CNNs), both convolution and pooling are locally performed for image regions separately, no contextual dependencies between different image regions have been taken into consideration. Such dependencies represent useful spatial structure information in images. Whereas recurrent neural networks (RNNs) are designed for learning contextual dependencies among sequential data by using the recurrent (feedback) connections. In this work, we propose the convolutional recurrent neural network (C-RNN), which learns the spatial dependencies between image regions to enhance the discriminative power of image representation. The C-RNN is trained in an end-to-end manner from raw pixel images. CNN layers are firstly processed to generate middle level features. RNN layer is then learned to encode spatial dependencies. The C-RNN can learn better image representation, especially for images with obvious spatial contextual dependencies. Our method achieves competitive performance on ILSVRC 2012, SUN 397, and MIT indoor. Two-stream Convolutional Networks (ConvNets) have shown strong performance for human action recognition in videos. Recently, Residual Networks (ResNets) have arisen as a new technique to train extremely deep architectures. In this paper, we introduce spatiotemporal ResNets as a combination of these two approaches. Our novel architecture generalizes ResNets for the spatiotemporal domain by introducing residual connections in two ways. First, we inject residual connections between the appearance and motion pathways of a two-stream architecture to allow spatiotemporal interaction between the two streams. Second, we transform pretrained image ConvNets into spatiotemporal networks by equipping these with learnable convolutional filters that are initialized as temporal residual connections and operate on adjacent feature maps in time. This approach slowly increases the spatiotemporal receptive field as the depth of the model increases and naturally integrates image ConvNet design principles. The whole model is trained end-to-end to allow hierarchical learning of complex spatiotemporal features. We evaluate our novel spatiotemporal ResNet using two widely used action recognition benchmarks where it exceeds the previous state-of-the-art.