Arterial spin labeling perfusion MRI is a noninvasive technique for measuring quantitative cerebral blood flow (CBF), but the measurement is subject to a low signal-to-noise-ratio(SNR). Various post-processing methods have been proposed to denoise ASL MRI but only provide moderate improvement. Deep learning (DL) is an emerging technique that can learn the most representative signal from data without prior modeling which can be highly complex and analytically indescribable. The purpose of this study was to assess whether the record breaking performance of DL can be translated into ASL MRI denoising. We used convolutional neural network (CNN) to build the DL ASL denosing model (DL-ASL) to inherently consider the inter-voxel correlations. To better guide DL-ASL training, we incorporated prior knowledge about ASL MRI: the structural similarity between ASL CBF map and grey matter probability map. A relatively large sample data were used to train the model which was subsequently applied to a new set of data for testing. Experimental results showed that DL-ASL achieved state-of-the-art denoising performance for ASL MRI as compared to current routine methods in terms of higher SNR, keeping CBF quantification quality while shorten the acquisition time by 75 , and automatic partial volume correction.
Imaging denoising is a classic low-level vision problem which have been widely studied in past decades. The image prior modeling often play a central role in image denoising. Traditional methods that used image prior knowledge as regularization techniques, scuh as nonlocal self-similarity models @cite_8 @cite_17 @cite_15 @cite_11 , Markov Random Field (MRF) @cite_9 @cite_12 @cite_19 and spares models @cite_0 @cite_13 , have shown very promising performance. However, in traditional denoising methods, image prior knowledge are explicitly pre-defined, which are often limited in capturing the full characteristics of image structure and limited in blind image denoising.
@cite_8 @cite_9 @cite_17 @cite_0 @cite_19 @cite_15 @cite_13 @cite_12 @cite_11
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Natural image modeling plays a key role in many vision problems such as image denoising. Image priors are widely used to regularize the denoising process, which is an illposed inverse problem. One category of denoising methods exploit the priors (e.g., TV, sparsity) learned from external clean images to reconstruct the given noisy image, while another category of methods exploit the internal prior (e.g., self-similarity) to reconstruct the latent image. Though the internal prior based methods have achieved impressive denoising results, the improvement of visual quality will become very difficult with the increase of noise level. In this paper, we propose to exploit image external patch prior and internal self-similarity prior jointly, and develop an external patch prior guided internal clustering algorithm for image denoising. It is known that natural image patches form multiple subspaces. By utilizing Gaussian mixture models (GMMs) learning, image similar patches can be clustered and the subspaces can be learned. The learned GMMs from clean images are then used to guide the clustering of noisypatches of the input noisy images, followed by a low-rank approximation process to estimate the latent subspace for image recovery. Numerical experiments show that the proposed method outperforms many state-of-the-art denoising algorithms such as BM3D and WNNM. Image denoising is a central problem in image processing and it is often a necessary step prior to higher level analysis such as segmentation, reconstruction, or super-resolution. The nonlocal means (NL-means) perform denoising by exploiting the natural redundancy of patterns inside an image; they perform a weighted average of pixels whose neighborhoods (patches) are close to each other. This reduces significantly the noise while preserving most of the image content. While it performs well on flat areas and textures, it suffers from two opposite drawbacks: it might over-smooth low-contrasted areas or leave a residual noise around edges and singular structures. Denoising can also be performed by total variation minimization-the Rudin, Osher and Fatemi model-which leads to restore regular images, but it is prone to over-smooth textures, staircasing effects, and contrast losses. We introduce in this paper a variational approach that corrects the over-smoothing and reduces the residual noise of the NL-means by adaptively regularizing nonlocal methods with the total variation. The proposed regularized NL-means algorithm combines these methods and reduces both of their respective defaults by minimizing an adaptive total variation with a nonlocal data fidelity term. Besides, this model adapts to different noise statistics and a fast solution can be obtained in the general case of the exponential family. We develop this model for image denoising and we adapt it to video denoising with 3D patches. Patch based image modeling has achieved a great success in low level vision such as image denoising. In particular, the use of image nonlocal self-similarity (NSS) prior, which refers to the fact that a local patch often has many nonlocal similar patches to it across the image, has significantly enhanced the denoising performance. However, in most existing methods only the NSS of input degraded image is exploited, while how to utilize the NSS of clean natural images is still an open problem. In this paper, we propose a patch group (PG) based NSS prior learning scheme to learn explicit NSS models from natural images for high performance denoising. PGs are extracted from training images by putting nonlocal similar patches into groups, and a PG based Gaussian Mixture Model (PG-GMM) learning algorithm is developed to learn the NSS prior. We demonstrate that, owe to the learned PG-GMM, a simple weighted sparse coding model, which has a closed-form solution, can be used to perform image denoising effectively, resulting in high PSNR measure, fast speed, and particularly the best visual quality among all competing methods. Demosaicking and denoising are the key first stages of the digital imaging pipeline but they are also a severely ill-posed problem that infers three color values per pixel from a single noisy measurement. Earlier methods rely on hand-crafted filters or priors and still exhibit disturbing visual artifacts in hard cases such as moire or thin edges. We introduce a new data-driven approach for these challenges: we train a deep neural network on a large corpus of images instead of using hand-tuned filters. While deep learning has shown great success, its naive application using existing training datasets does not give satisfactory results for our problem because these datasets lack hard cases. To create a better training set, we present metrics to identify difficult patches and techniques for mining community photographs for such patches. Our experiments show that this network and training procedure outperform state-of-the-art both on noisy and noise-free data. Furthermore, our algorithm is an order of magnitude faster than the previous best performing techniques.