Limited capture range, and the requirement to provide high quality initialization for optimization-based 2D 3D image registration methods, can significantly degrade the performance of 3D image reconstruction and motion compensation pipelines. Challenging clinical imaging scenarios, which contain significant subject motion such as fet al in-utero imaging, complicate the 3D image and volume reconstruction process. In this paper we present a learning based image registration method capable of predicting 3D rigid transformations of arbitrarily oriented 2D image slices, with respect to a learned canonical atlas co-ordinate system. Only image slice intensity information is used to perform registration and canonical alignment, no spatial transform initialization is required. To find image transformations we utilize a Convolutional Neural Network (CNN) architecture to learn the regression function capable of mapping 2D image slices to a 3D canonical atlas space. We extensively evaluate the effectiveness of our approach quantitatively on simulated Magnetic Resonance Imaging (MRI), fet al brain imagery with synthetic motion and further demonstrate qualitative results on real fet al MRI data where our method is integrated into a full reconstruction and motion compensation pipeline. Our learning based registration achieves an average spatial prediction error of 7 mm on simulated data and produces qualitatively improved reconstructions for heavily moving fetuses with gestational ages of approximately 20 weeks. Our model provides a general and computationally efficient solution to the 2D 3D registration initialization problem and is suitable for real-time scenarios.
@cite_30 use Convolutional Neural Networks (CNNs) to automatically estimate the spatial arrangement of landmarks in projection images. Their method utilizes a CNN to regress transformation residuals, @math , which refines the required transformation to register a source volume to a target X-ray image from an initially assumed position @math . Registration is then performed iteratively using synthetic Digitally Reconstructed Radiography (DRR) images generated from the source volume using @math . To address inaccurate transformation mappings caused by direct regression of transformation parameters, train their CNN using Pose-index features (landmarks) extracted from source and target image pairs and learn their @math . Pose-index features are insensitive to transform parameters @math yet sensitive to change in @math . This insensitivity to @math can be expressed as @math . The method requires a robust landmark detection algorithm, which is domain and scanner specific and the detection quality degrades for motion-corrupted data.
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Convolutional neural networks (CNNs) have demonstrated their ability object detection of very high resolution remote sensing images. However, CNNs have obvious limitations for modeling geometric variations in remote sensing targets. In this paper, we introduced a CNN structure, namely deformable ConvNet, to address geometric modeling in object recognition. By adding offsets to the convolution layers, feature mapping of CNN can be applied to unfixed locations, enhancing CNNs’ visual appearance understanding. In our work, a deformable region-based fully convolutional networks (R-FCN) was constructed by substituting the regular convolution layer with a deformable convolution layer. To efficiently use this deformable convolutional neural network (ConvNet), a training mechanism is developed in our work. We first set the pre-trained R-FCN natural image model as the default network parameters in deformable R-FCN. Then, this deformable ConvNet was fine-tuned on very high resolution (VHR) remote sensing images. To remedy the increase in lines like false region proposals, we developed aspect ratio constrained non maximum suppression (arcNMS). The precision of deformable ConvNet for detecting objects was then improved. An end-to-end approach was then developed by combining deformable R-FCN, a smart fine-tuning strategy and aspect ratio constrained NMS. The developed method was better than a state-of-the-art benchmark in object detection without data augmentation.