Signet ring cell carcinoma is a type of rare adenocarcinoma with poor prognosis. Early detection leads to huge improvement of patients’ survival rate. However, pathologists can only visually detect signet ring cells under the microscope. This procedure is not only laborious but also prone to omission. An automatic and accurate signet ring cell detection solution is thus important but has not been investigated before. In this paper, we take the first step to present a semi-supervised learning framework for the signet ring cell detection problem. Self-training is proposed to deal with the challenge of incomplete annotations, and cooperative-training is adapted to explore the unlabeled regions. Combining the two techniques, our semi-supervised learning framework can make better use of both labeled and unlabeled data. Experiments on large real clinical data demonstrate the effectiveness of our design. Our framework achieves accurate signet ring cell detection and can be readily applied in the clinical trails. The dataset will be released soon to facilitate the development of the area.
Several semi-supervised learning methods have been proposed and verified their effectiveness on natural images @cite_13 @cite_5 @cite_9 @cite_4 @cite_16 @cite_0 . @cite_4 used box-level annotation to achieve similar performance with pixel-level annotation. @cite_9 organized a reconstruction head to convert segmentation output back to original images. Generally, all the previous methods focus on training one model with complex auxiliary branches. On the contrary, our semi-supervised learning framework can organize the multiple models to support each other and no extra auxiliary branch is needed. There have been lots of automatic methods for pathology, including nuclei segmentation @cite_12 @cite_8 @cite_18 and specific object @cite_10 . However, automatic signet ring cell detection has not been investigated before to our best knowledge.
@cite_18 @cite_4 @cite_8 @cite_10 @cite_9 @cite_0 @cite_5 @cite_16 @cite_13 @cite_12
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Supervised contour detection methods usually require many labeled training images to obtain satisfactory performance. However, a large set of annotated data might be unavailable or extremely labor intensive. In this paper, we investigate the usage of semi-supervised learning (SSL) to obtain competitive detection accuracy with very limited training data (three labeled images). Specifically, we propose a semi-supervised structured ensemble learning approach for contour detection built on structured random forests (SRF). To allow SRF to be applicable to unlabeled data, we present an effective sparse representation approach to capture inherent structure in image patches by finding a compact and discriminative low-dimensional subspace representation in an unsupervised manner, enabling the incorporation of abundant unlabeled patches with their estimated structured labels to help SRF perform better node splitting. We re-examine the role of sparsity and propose a novel and fast sparse coding algorithm to boost the overall learning efficiency. To the best of our knowledge, this is the first attempt to apply SSL for contour detection. Extensive experiments on the BSDS500 segmentation dataset and the NYU Depth dataset demonstrate the superiority of the proposed method. Supervised object detection and semantic segmentation require object or even pixel level annotations. When there exist image level labels only, it is challenging for weakly supervised algorithms to achieve accurate predictions. The accuracy achieved by top weakly supervised algorithms is still significantly lower than their fully supervised counterparts. In this paper, we propose a novel weakly supervised curriculum learning pipeline for multi-label object recognition, detection and semantic segmentation. In this pipeline, we first obtain intermediate object localization and pixel labeling results for the training images, and then use such results to train task-specific deep networks in a fully supervised manner. The entire process consists of four stages, including object localization in the training images, filtering and fusing object instances, pixel labeling for the training images, and task-specific network training. To obtain clean object instances in the training images, we propose a novel algorithm for filtering, fusing and classifying object instances collected from multiple solution mechanisms. In this algorithm, we incorporate both metric learning and density-based clustering to filter detected object instances. Experiments show that our weakly supervised pipeline achieves state-of-the-art results in multi-label image classification as well as weakly supervised object detection and very competitive results in weakly supervised semantic segmentation on MS-COCO, PASCAL VOC 2007 and PASCAL VOC 2012. We present an adversarial domain adaptation based deep learning approach for automatic tumor segmentation from T2-weighted MRI. Our approach is composed of two steps: (i) a tumor-aware unsupervised cross-domain adaptation (CT to MRI), followed by (ii) semi-supervised tumor segmentation using Unet trained with synthesized and limited number of original MRIs. We introduced a novel target specific loss, called tumor-aware loss, for unsupervised cross-domain adaptation that helps to preserve tumors on synthesized MRIs produced from CT images. In comparison, state-of-the art adversarial networks trained without our tumor-aware loss produced MRIs with ill-preserved or missing tumors. All networks were trained using labeled CT images from 377 patients with non-small cell lung cancer obtained from the Cancer Imaging Archive and unlabeled T2w MRIs from a completely unrelated cohort of 6 patients with pre-treatment and 36 on-treatment scans. Next, we combined 6 labeled pre-treatment MRI scans with the synthesized MRIs to boost tumor segmentation accuracy through semi-supervised learning. Semi-supervised training of cycle-GAN produced a segmentation accuracy of 0.66 computed using Dice Score Coefficient (DSC). Our method trained with only synthesized MRIs produced an accuracy of 0.74 while the same method trained in semi-supervised setting produced the best accuracy of 0.80 on test. Our results show that tumor-aware adversarial domain adaptation helps to achieve reasonably accurate cancer segmentation from limited MRI data by leveraging large CT datasets. Fully convolutional networks (FCN) have achieved great success in human parsing in recent years. In conventional human parsing tasks, pixel-level labeling is required for guiding the training, which usually involves enormous human labeling efforts. To ease the labeling efforts, we propose a novel weakly supervised human parsing method which only requires simple object keypoint annotations for learning. We develop an iterative learning method to generate pseudo part segmentation masks from keypoint labels. With these pseudo masks, we train an FCN network to output pixel-level human parsing predictions. Furthermore, we develop a correlation network to perform joint prediction of part and object segmentation masks and improve the segmentation performance. The experiment results show that our weakly supervised method is able to achieve very competitive human parsing results. Despite our method only uses simple keypoint annotations for learning, we are able to achieve comparable performance with fully supervised methods which use the expensive pixel-level annotations. Learning representative computational models from medical imaging data requires large training data sets. Often, voxel-level annotation is unfeasible for sufficient amounts of data. An alternative to manual annotation, is to use the enormous amount of knowledge encoded in imaging data and corresponding reports generated during clinical routine. Weakly supervised learning approaches can link volume-level labels to image content but suffer from the typical label distributions in medical imaging data where only a small part consists of clinically relevant abnormal structures. In this paper we propose to use a semantic representation of clinical reports as a learning target that is predicted from imaging data by a convolutional neural network. We demonstrate how we can learn accurate voxel-level classifiers based on weak volume-level semantic descriptions on a set of 157 optical coherence tomography (OCT) volumes. We specifically show how semantic information increases classification accuracy for intraretinal cystoid fluid (IRC), subretinal fluid (SRF) and normal retinal tissue, and how the learning algorithm links semantic concepts to image content and geometry. We address the problem of semantic segmentation: classifying each pixel in an image according to the semantic class it belongs to (e.g. dog, road, car). Most existing methods train from fully supervised images, where each pixel is annotated by a class label. To reduce the annotation effort, recently a few weakly supervised approaches emerged. These require only image labels indicating which classes are present. Although their performance reaches a satisfactory level, there is still a substantial gap between the accuracy of fully and weakly supervised methods. We address this gap with a novel active learning method specifically suited for this setting. We model the problem as a pairwise CRF and cast active learning as finding its most informative nodes. These nodes induce the largest expected change in the overall CRF state, after revealing their true label. Our criterion is equivalent to maximizing an upper-bound on accuracy gain. Experiments on two data-sets show that our method achieves 97 percent of the accuracy of the corresponding fully supervised model, while querying less than 17 of the (super-)pixel labels. Over the last years, deep convolutional neural networks (ConvNets) have transformed the field of computer vision thanks to their unparalleled capacity to learn high level semantic image features. However, in order to successfully learn those features, they usually require massive amounts of manually labeled data, which is both expensive and impractical to scale. Therefore, unsupervised semantic feature learning, i.e., learning without requiring manual annotation effort, is of crucial importance in order to successfully harvest the vast amount of visual data that are available today. In our work we propose to learn image features by training ConvNets to recognize the 2d rotation that is applied to the image that it gets as input. We demonstrate both qualitatively and quantitatively that this apparently simple task actually provides a very powerful supervisory signal for semantic feature learning. We exhaustively evaluate our method in various unsupervised feature learning benchmarks and we exhibit in all of them state-of-the-art performance. Specifically, our results on those benchmarks demonstrate dramatic improvements w.r.t. prior state-of-the-art approaches in unsupervised representation learning and thus significantly close the gap with supervised feature learning. For instance, in PASCAL VOC 2007 detection task our unsupervised pre-trained AlexNet model achieves the state-of-the-art (among unsupervised methods) mAP of 54.4 that is only 2.4 points lower from the supervised case. We get similarly striking results when we transfer our unsupervised learned features on various other tasks, such as ImageNet classification, PASCAL classification, PASCAL segmentation, and CIFAR-10 classification. The code and models of our paper will be published on: this https URL . Abstract Weakly-supervised learning based on, e.g., partially labelled images or image-tags, is currently attracting significant attention in CNN segmentation as it can mitigate the need for full and laborious pixel voxel annotations. Enforcing high-order (global) inequality constraints on the network output (for instance, to constrain the size of the target region) can leverage unlabeled data, guiding the training process with domain-specific knowledge. Inequality constraints are very flexible because they do not assume exact prior knowledge. However, constrained Lagrangian dual optimization has been largely avoided in deep networks, mainly for computational tractability reasons. To the best of our knowledge, the method of (2015a) is the only prior work that addresses deep CNNs with linear constraints in weakly supervised segmentation. It uses the constraints to synthesize fully-labeled training masks (proposals) from weak labels, mimicking full supervision and facilitating dual optimization. We propose to introduce a differentiable penalty, which enforces inequality constraints directly in the loss function, avoiding expensive Lagrangian dual iterates and proposal generation. From constrained-optimization perspective, our simple penalty-based approach is not optimal as there is no guarantee that the constraints are satisfied. However, surprisingly, it yields substantially better results than the Lagrangian-based constrained CNNs in (2015a) , while reducing the computational demand for training. By annotating only a small fraction of the pixels, the proposed approach can reach a level of segmentation performance that is comparable to full supervision on three separate tasks. While our experiments focused on basic linear constraints such as the target-region size and image tags, our framework can be easily extended to other non-linear constraints, e.g., invariant shape moments (Klodt and Cremers, 2011) and other region statistics (, 2014). Therefore, it has the potential to close the gap between weakly and fully supervised learning in semantic medical image segmentation. Our code is publicly available. The goal of this work is to automatically collect a large number of highly relevant natural images from Internet for given queries. A novel automatic image dataset construction framework is proposed by employing multiple query expansions. In specific, the given queries are first expanded by searching in the Google Books Ngrams Corpora to obtain a richer semantic descriptions, from which the visually non-salient and less relevant expansions are then filtered. After retrieving images from the Internet with filtered expansions, we further filter noisy images by clustering and progressively Convolutional Neural Networks (CNN) based methods. To evaluate the performance of our proposed method for image dataset construction, we build an image dataset with 10 categories. We then run object detections on our image dataset with three other image datasets which were constructed by weak supervised, web supervised and full supervised learning, the experimental results indicated the effectiveness of our method is superior to weak supervised and web supervised state-of-the-art methods. In addition, we do a cross-dataset classification to evaluate the performance of our dataset with two publically available manual labelled dataset STL-10 and CIFAR-10. Over the last years, deep convolutional neural networks (ConvNets) have transformed the field of computer vision thanks to their unparalleled capacity to learn high level semantic image features. However, in order to successfully learn those features, they usually require massive amounts of manually labeled data, which is both expensive and impractical to scale. Therefore, unsupervised semantic feature learning, i.e., learning without requiring manual annotation effort, is of crucial importance in order to successfully harvest the vast amount of visual data that are available today. In our work we propose to learn image features by training ConvNets to recognize the 2d rotation that is applied to the image that it gets as input. We demonstrate both qualitatively and quantitatively that this apparently simple task actually provides a very powerful supervisory signal for semantic feature learning. We exhaustively evaluate our method in various unsupervised feature learning benchmarks and we exhibit in all of them state-of-the-art performance. Specifically, our results on those benchmarks demonstrate dramatic improvements w.r.t. prior state-of-the-art approaches in unsupervised representation learning and thus significantly close the gap with supervised feature learning. For instance, in PASCAL VOC 2007 detection task our unsupervised pre-trained AlexNet model achieves the state-of-the-art (among unsupervised methods) mAP of 54.4 that is only 2.4 points lower from the supervised case. We get similar striking results when we transfer our unsupervised learned features on various other tasks, such as ImageNet classification, PASCAL classification, PASCAL segmentation, and CIFAR-10 classification.