Accurate identification and localization of abnormalities from radiology images play an integral part in clinical diagnosis and treatment planning. Building a highly accurate prediction model for these tasks usually requires a large number of images manually annotated with labels and finding sites of abnormalities. In reality, however, such annotated data are expensive to acquire, especially the ones with location annotations. We need methods that can work well with only a small amount of location annotations. To address this challenge, we present a unified approach that simultaneously performs disease identification and localization through the same underlying model for all images. We demonstrate that our approach can effectively leverage both class information as well as limited location annotation, and significantly outperforms the comparative reference baseline in both classification and localization tasks.
Zhang al proposed a dual-attention model using images and optional texts to make accurate prediction @cite_33 . In @cite_14 , Zhang al proposed an image-to-text model to establish a direct mapping from medical images to diagnostic reports. Both models were evaluated on a dataset of bladder cancer images and corresponding diagnostic reports. Wang al took advantage of a large-scale chest X-ray dataset to formulate the disease diagnosis problem as multi-label classification, using class-specific image feature transformation @cite_39 . They also applied a thresholding method to the feature map visualization @cite_11 for each class and derived the bounding box for each disease. Their qualitative results showed that the model usually generated much larger bounding box than the ground-truth. Hwang al @cite_30 proposed a self-transfer learning framework to learn localization from the globally pooled class-specific feature maps supervised by image labels. These works have the same essence with class activation mapping @cite_19 which handles natural images. The location annotation information was not directly formulated into the loss function in the none of these works. Feature map pooling based localization did not effectively capture the precise disease regions.
@cite_30 @cite_14 @cite_33 @cite_39 @cite_19 @cite_11
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The inability to interpret the model prediction in semantically and visually meaningful ways is a well-known shortcoming of most existing computer-aided diagnosis methods. In this paper, we propose MDNet to establish a direct multimodal mapping between medical images and diagnostic reports that can read images, generate diagnostic reports, retrieve images by symptom descriptions, and visualize attention, to provide justifications of the network diagnosis process. MDNet includes an image model and a language model. The image model is proposed to enhance multi-scale feature ensembles and utilization efficiency. The language model, integrated with our improved attention mechanism, aims to read and explore discriminative image feature descriptions from reports to learn a direct mapping from sentence words to image pixels. The overall network is trained end-to-end by using our developed optimization strategy. Based on a pathology bladder cancer images and its diagnostic reports (BCIDR) dataset, we conduct sufficient experiments to demonstrate that MDNet outperforms comparative baselines. The proposed image model obtains state-of-the-art performance on two CIFAR datasets as well. In this paper, we introduce the semantic knowledge of medical images from their diagnostic reports to provide an inspirational network training and an interpretable prediction mechanism with our proposed novel multimodal neural network, namely TandemNet. Inside TandemNet, a language model is used to represent report text, which cooperates with the image model in a tandem scheme. We propose a novel dual-attention model that facilitates high-level interactions between visual and semantic information and effectively distills useful features for prediction. In the testing stage, TandemNet can make accurate image prediction with an optional report text input. It also interprets its prediction by producing attention on the image and text informative feature pieces, and further generating diagnostic report paragraphs. Based on a pathological bladder cancer images and their diagnostic reports (BCIDR) dataset, sufficient experiments demonstrate that our method effectively learns and integrates knowledge from multimodalities and obtains significantly improved performance than comparing baselines. The chest X-ray is one of the most commonly accessible radiological examinations for screening and diagnosis of many lung diseases. A tremendous number of X-ray imaging studies accompanied by radiological reports are accumulated and stored in many modern hospitals Picture Archiving and Communication Systems (PACS). On the other side, it is still an open question how this type of hospital-size knowledge database containing invaluable imaging informatics (i.e., loosely labeled) can be used to facilitate the data-hungry deep learning paradigms in building truly large-scale high precision computer-aided diagnosis (CAD) systems. In this paper, we present a new chest X-ray database, namely ChestX-ray8, which comprises 108,948 frontal-view X-ray images of 32,717 unique patients with the text-mined eight disease image labels (where each image can have multi-labels), from the associated radiological reports using natural language processing. Importantly, we demonstrate that these commonly occurring thoracic diseases can be detected and even spatially-located via a unified weakly-supervised multi-label image classification and disease localization framework, which is validated using our proposed dataset. Although the initial quantitative results are promising as reported, deep convolutional neural network based reading chest X-rays (i.e., recognizing and locating the common disease patterns trained with only image-level labels) remains a strenuous task for fully-automated high precision CAD systems. Chest X-ray is one of the most accessible medical imaging technique for diagnosis of multiple diseases. With the availability of ChestX-ray14, which is a massive dataset of chest X-ray images and provides annotations for 14 thoracic diseases; it is possible to train Deep Convolutional Neural Networks (DCNN) to build Computer Aided Diagnosis (CAD) systems. In this work, we experiment a set of deep learning models and present a cascaded deep neural network that can diagnose all 14 pathologies better than the baseline and is competitive with other published methods. Our work provides the quantitative results to answer following research questions for the dataset: 1) What loss functions to use for training DCNN from scratch on ChestX-ray14 dataset that demonstrates high class imbalance and label co occurrence? 2) How to use cascading to model label dependency and to improve accuracy of the deep learning model? Diagnostic imaging often requires the simultaneous identification of a multitude of findings of varied size and appearance. Beyond global indication of said findings, the prediction and display of localization information improves trust in and understanding of results when augmenting clinical workflow. Medical training data rarely includes more than global image-level labels as segmentations are time-consuming and expensive to collect. We introduce an approach to managing these practical constraints by applying a novel architecture which learns at multiple resolutions while generating saliency maps with weak supervision. Further, we parameterize the Log-Sum-Exp pooling function with a learnable lower-bounded adaptation (LSE-LBA) to build in a sharpness prior and better handle localizing abnormalities of different sizes using only image-level labels. Applying this approach to interpreting chest x-rays, we set the state of the art on 9 abnormalities in the NIH's CXR14 dataset while generating saliency maps with the highest resolution to date. Chest X-rays is one of the most commonly available and affordable radiological examinations in clinical practice. While detecting thoracic diseases on chest X-rays is still a challenging task for machine intelligence, due to 1) the highly varied appearance of lesion areas on X-rays from patients of different thoracic disease and 2) the shortage of accurate pixel-level annotations by radiologists for model training. Existing machine learning methods are unable to deal with the challenge that thoracic diseases usually happen in localized disease-specific areas. In this article, we propose a weakly supervised deep learning framework equipped with squeeze-and-excitation blocks, multi-map transfer and max-min pooling for classifying common thoracic diseases as well as localizing suspicious lesion regions on chest X-rays. The comprehensive experiments and discussions are performed on the ChestX-ray14 dataset. Both numerical and visual results have demonstrated the effectiveness of proposed model and its better performance against the state-of-the-art pipelines. Despite the recent advances in automatically describing image contents, their applications have been mostly limited to image caption datasets containing natural images (e.g., Flickr 30k, MSCOCO). In this paper, we present a deep learning model to efficiently detect a disease from an image and annotate its contexts (e.g., location, severity and the affected organs). We employ a publicly available radiology dataset of chest x-rays and their reports, and use its image annotations to mine disease names to train convolutional neural networks (CNNs). In doing so, we adopt various regularization techniques to circumvent the large normal-vs-diseased cases bias. Recurrent neural networks (RNNs) are then trained to describe the contexts of a detected disease, based on the deep CNN features. Moreover, we introduce a novel approach to use the weights of the already trained pair of CNN RNN on the domain-specific image text dataset, to infer the joint image text contexts for composite image labeling. Significantly improved image annotation results are demonstrated using the recurrent neural cascade model by taking the joint image text contexts into account. In this work, we exploit the task of joint classification and weakly supervised localization of thoracic diseases from chest radiographs, with only image-level disease labels coupled with disease severity-level (DSL) information of a subset. A convolutional neural network (CNN) based attention-guided curriculum learning (AGCL) framework is presented, which leverages the severity-level attributes mined from radiology reports. Images in order of difficulty (grouped by different severity-levels) are fed to CNN to boost the learning gradually. In addition, highly confident samples (measured by classification probabilities) and their corresponding class-conditional heatmaps (generated by the CNN) are extracted and further fed into the AGCL framework to guide the learning of more distinctive convolutional features in the next iteration. A two-path network architecture is designed to regress the heatmaps from selected seed samples in addition to the original classification task. The joint learning scheme can improve the classification and localization performance along with more seed samples for the next iteration. We demonstrate the effectiveness of this iterative refinement framework via extensive experimental evaluations on the publicly available ChestXray14 dataset. AGCL achieves over 5.7 (averaged over 14 diseases) increase in classification AUC and 7 11 increases in Recall Precision for the localization task compared to the state of the art. In this paper we introduce and experiment with a framework for learning local perceptual distance functions for visual recognition. We learn a distance function for each training image as a combination of elementary distances between patch-based visual features. We apply these combined local distance functions to the tasks of image retrieval and classification of novel images. On the Caltech 101 object recognition benchmark, we achieve 60.3 mean recognition across classes using 15 training images per class, which is better than the best published performance by Zhang, et al We aim to model the top-down attention of a convolutional neural network (CNN) classifier for generating task-specific attention maps. Inspired by a top-down human visual attention model, we propose a new backpropagation scheme, called Excitation Backprop, to pass along top-down signals downwards in the network hierarchy via a probabilistic Winner-Take-All process. Furthermore, we introduce the concept of contrastive attention to make the top-down attention maps more discriminative. We show a theoretic connection between the proposed contrastive attention formulation and the Class Activation Map computation. Efficient implementation of Excitation Backprop for common neural network layers is also presented. In experiments, we visualize the evidence of a model’s classification decision by computing the proposed top-down attention maps. For quantitative evaluation, we report the accuracy of our method in weakly supervised localization tasks on the MS COCO, PASCAL VOC07 and ImageNet datasets. The usefulness of our method is further validated in the text-to-region association task. On the Flickr30k Entities dataset, we achieve promising performance in phrase localization by leveraging the top-down attention of a CNN model that has been trained on weakly labeled web images. Finally, we demonstrate applications of our method in model interpretation and data annotation assistance for facial expression analysis and medical imaging tasks. Recently, deep convolutional neural networks (DCNNs) have significantly promoted the development of semantic image segmentation. However, previous works on learning the segmentation network often rely on a large number of ground-truths with pixel-level annotations, which usually require considerable human effort. In this paper, we explore a more challenging problem by learning to segment under image-level annotations. Specifically, our framework consists of two components. First, reliable hypotheses based localization maps are generated by incorporating the hypotheses-aware classification and cross-image contextual refinement. Second, the segmentation network can be trained in a supervised manner by these generated localization maps. We explore two network training strategies for achieving good segmentation performance. For the first strategy, a novel multi-label cross-entropy loss is proposed to train the network by directly using multiple localization maps for all classes, where each pixel contributes to each class with different weights. For the second strategy, the rough segmentation mask can be inferred from the localization maps, and then the network is optimized based on the single-label cross-entropy loss with the produced masks. We evaluate our methods on the PASCAL VOC 2012 segmentation benchmark. Extensive experimental results demonstrate the effectiveness of the proposed methods compared with the state-of-the-arts. HighlightsLocalization map generation is proposed by using the hypothesis-based classification.A novel multi-label loss is proposed to train the network based on localization maps.An effective method is proposed to predict the rough mask of the given training image.Our methods achieve new state-of-the-art results on PASCAL VOC 2012 benchmark. This paper considers the task of thorax disease classification on chest X-ray images. Existing methods generally use the global image as input for network learning. Such a strategy is limited in two aspects. 1) A thorax disease usually happens in (small) localized areas which are disease specific. Training CNNs using global image may be affected by the (excessive) irrelevant noisy areas. 2) Due to the poor alignment of some CXR images, the existence of irregular borders hinders the network performance. In this paper, we address the above problems by proposing a three-branch attention guided convolution neural network (AG-CNN). AG-CNN 1) learns from disease-specific regions to avoid noise and improve alignment, 2) also integrates a global branch to compensate the lost discriminative cues by local branch. Specifically, we first learn a global CNN branch using global images. Then, guided by the attention heat map generated from the global branch, we inference a mask to crop a discriminative region from the global image. The local region is used for training a local CNN branch. Lastly, we concatenate the last pooling layers of both the global and local branches for fine-tuning the fusion branch. The Comprehensive experiment is conducted on the ChestX-ray14 dataset. We first report a strong global baseline producing an average AUC of 0.841 with ResNet-50 as backbone. After combining the local cues with the global information, AG-CNN improves the average AUC to 0.868. While DenseNet-121 is used, the average AUC achieves 0.871, which is a new state of the art in the community. State-of-the-art methods treat pedestrian attribute recognition as a multi-label image classification problem. The location information of person attributes is usually eliminated or simply encoded in the rigid splitting of whole body in previous work. In this paper, we formulate the task in a weakly-supervised attribute localization framework. Based on GoogLeNet, firstly, a set of mid-level attribute features are discovered by novelly designed detection layers, where a max-pooling based weakly-supervised object detection technique is used to train these layers with only image-level labels without the need of bounding box annotations of pedestrian attributes. Secondly, attribute labels are predicted by regression of the detection response magnitudes. Finally, the locations and rough shapes of pedestrian attributes can be inferred by performing clustering on a fusion of activation maps of the detection layers, where the fusion weights are estimated as the correlation strengths between each attribute and its relevant mid-level features. Extensive experiments are performed on the two currently largest pedestrian attribute datasets, i.e. the PETA dataset and the RAP dataset. Results show that the proposed method has achieved competitive performance on attribute recognition, compared to other state-of-the-art methods. Moreover, the results of attribute localization are visualized to understand the characteristics of the proposed method. In this paper, we propose a novel weakly supervised model, Multi-scale Anchored Transformer Network (MATN), to accurately localize free-form textual phrases with only image-level supervision. The proposed MATN takes region proposals as localization anchors, and learns a multiscale correspondence network to continuously search for phrase regions referring to the anchors. In this way, MATN can exploit useful cues from these anchors to reliably reason about locations of the regions described by the phrases given only image-level supervision. Through differentiable sampling on image spatial feature maps, MATN introduces a novel training objective to simultaneously minimize a contrastive reconstruction loss between different phrases from a single image and a set of triplet losses among multiple images with similar phrases. Superior to existing region proposal based methods, MATN searches for the optimal bounding box over the entire feature map instead of selecting a sub-optimal one from discrete region proposals. We evaluate MATN on the Flickr30K Entities and ReferItGame datasets. The experimental results show that MATN significantly outperforms the state-of-the-art methods. Convolutional neural networks (CNNs) have shown great performance as general feature representations for object recognition applications. However, for multi-label images that contain multiple objects from different categories, scales and locations, global CNN features are not optimal. In this paper, we incorporate local information to enhance the feature discriminative power. In particular, we first extract object proposals from each image. With each image treated as a bag and object proposals extracted from it treated as instances, we transform the multi-label recognition problem into a multi-class multi-instance learning problem. Then, in addition to extracting the typical CNN feature representation from each proposal, we propose to make use of ground-truth bounding box annotations (strong labels) to add another level of local information by using nearest-neighbor relationships of local regions to form a multi-view pipeline. The proposed multi-view multiinstance framework utilizes both weak and strong labels effectively, and more importantly it has the generalization ability to even boost the performance of unseen categories by partial strong labels from other categories. Our framework is extensively compared with state-of-the-art handcrafted feature based methods and CNN based methods on two multi-label benchmark datasets. The experimental results validate the discriminative power and the generalization ability of the proposed framework. With strong labels, our framework is able to achieve state-of-the-art results in both datasets. The effectiveness of generative adversarial approaches in producing images according to a specific style or visual domain has recently opened new directions to solve the unsupervised domain adaptation problem. It has been shown that source labeled images can be modified to mimic target samples making it possible to train directly a classifier in the target domain, despite the original lack of annotated data. Inverse mappings from the target to the source domain have also been evaluated but only passing through adapted feature spaces, thus without new image generation. In this paper we propose to better exploit the potential of generative adversarial networks for adaptation by introducing a novel symmetric mapping among domains. We jointly optimize bi-directional image transformations combining them with target self-labeling. Moreover we define a new class consistency loss that aligns the generators in the two directions imposing to conserve the class identity of an image passing through both domain mappings. A detailed qualitative and quantitative analysis of the reconstructed images confirm the power of our approach. By integrating the two domain specific classifiers obtained with our bi-directional network we exceed previous state-of-the-art unsupervised adaptation results on four different benchmark datasets. A probabilistic formulation for semantic image annotation and retrieval is proposed. Annotation and retrieval are posed as classification problems where each class is defined as the group of database images labeled with a common semantic label. It is shown that, by establishing this one-to-one correspondence between semantic labels and semantic classes, a minimum probability of error annotation and retrieval are feasible with algorithms that are 1) conceptually simple, 2) computationally efficient, and 3) do not require prior semantic segmentation of training images. In particular, images are represented as bags of localized feature vectors, a mixture density estimated for each image, and the mixtures associated with all images annotated with a common semantic label pooled into a density estimate for the corresponding semantic class. This pooling is justified by a multiple instance learning argument and performed efficiently with a hierarchical extension of expectation-maximization. The benefits of the supervised formulation over the more complex, and currently popular, joint modeling of semantic label and visual feature distributions are illustrated through theoretical arguments and extensive experiments. The supervised formulation is shown to achieve higher accuracy than various previously published methods at a fraction of their computational cost. Finally, the proposed method is shown to be fairly robust to parameter tuning Recent advances of deep learning have achieved remarkable performances in various challenging computer vision tasks. Especially in object localization, deep convolutional neural networks outperform traditional approaches based on extraction of data task-driven features instead of hand-crafted features. Although location information of region-of-interests (ROIs) gives good prior for object localization, it requires heavy annotation efforts from human resources. Thus a weakly supervised framework for object localization is introduced. The term "weakly" means that this framework only uses image-level labeled datasets to train a network. With the help of transfer learning which adopts weight parameters of a pre-trained network, the weakly supervised learning framework for object localization performs well because the pre-trained network already has well-trained class-specific features. However, those approaches cannot be used for some applications which do not have pre-trained networks or well-localized large scale images. Medical image analysis is a representative among those applications because it is impossible to obtain such pre-trained networks. In this work, we present a "fully" weakly supervised framework for object localization ("semi"-weakly is the counterpart which uses pre-trained filters for weakly supervised localization) named as self-transfer learning (STL). It jointly optimizes both classification and localization networks simultaneously. By controlling a supervision level of the localization network, STL helps the localization network focus on correct ROIs without any types of priors. We evaluate the proposed STL framework using two medical image datasets, chest X-rays and mammograms, and achieve signiticantly better localization performance compared to previous weakly supervised approaches. Training deep learning based video classifiers for action recognition requires a large amount of labeled videos. The labeling process is labor-intensive and time-consuming. On the other hand, large amount of weakly-labeled images are uploaded to the Internet by users everyday. To harness the rich and highly diverse set of Web images, a scalable approach is to crawl these images to train deep learning based classifier, such as Convolutional Neural Networks (CNN). However, due to the domain shift problem, the performance of Web images trained deep classifiers tend to degrade when directly deployed to videos. One way to address this problem is to fine-tune the trained models on videos, but sufficient amount of annotated videos are still required. In this work, we propose a novel approach to transfer knowledge from image domain to video domain. The proposed method can adapt to the target domain (i.e. video data) with limited amount of training data. Our method maps the video frames into a low-dimensional feature space using the class-discriminative spatial attention map for CNNs. We design a novel Siamese EnergyNet structure to learn energy functions on the attention maps by jointly optimizing two loss functions, such that the attention map corresponding to a ground truth concept would have higher energy. We conduct extensive experiments on two challenging video recognition datasets (i.e. TVHI and UCF101), and demonstrate the efficacy of our proposed method. We propose to revisit knowledge transfer for training object detectors on target classes from weakly supervised training images, helped by a set of source classes with bounding-box annotations. We present a unified knowledge transfer framework based on training a single neural network multi-class object detector over all source classes, organized in a semantic hierarchy. This generates proposals with scores at multiple levels in the hierarchy, which we use to explore knowledge transfer over a broad range of generality, ranging from class-specific (bycicle to motorbike) to class-generic (objectness to any class). Experiments on the 200 object classes in the ILSVRC 2013 detection dataset show that our technique (1) leads to much better performance on the target classes (70.3 CorLoc, 36.9 mAP) than a weakly supervised baseline which uses manually engineered objectness [11] (50.5 CorLoc, 25.4 mAP). (2) delivers target object detectors reaching 80 of the mAP of their fully supervised counterparts. (3) outperforms the best reported transfer learning results on this dataset (+41 CorLoc and +3 mAP over [18, 46], +16.2 mAP over [32]). Moreover, we also carry out several across-dataset knowledge transfer experiments [27, 24, 35] and find that (4) our technique outperforms the weakly supervised baseline in all dataset pairs by 1.5 A— - 1.9A—, establishing its general applicability.