Multi-modal data is becoming more common in big data background. Finding the semantically similar objects from different modality is one of the heart problems of multi-modal learning. Most of the current methods try to learn the inter-modal correlation with extrinsic supervised information, while intrinsic structural information of each modality is neglected. The performance of these methods heavily depends on the richness of training samples. However, obtaining the multi-modal training samples is still a labor and cost intensive work. In this paper, we bring a extrinsic correlation between the space structures of each modalities in coreference resolution. With this correlation, a semi-supervised learning model for multi-modal coreference resolution is proposed. We firstly extract high-level features of images and text, then compute the distances of each object from some reference points to build the space structure of each modality. With a shared reference point set, the space structures of each modality are correlated. We employ the correlation to build a commonly shared space that the semantic distance between multi-modal objects can be computed directly. The experiments on two multi-modal datasets show that our model performs better than the existing methods with insufficient training data.
Besides these methods above, there still are other models proposed for multi-modal problems. @cite_24 employed voxel-based multi-modal partial least square(PLS) to analyze the correlations between FDG PET glucose uptake-MRI gray matter volume scores and apolipoprotein E epsilon 4 gene dose in cognitively normal adults.
@cite_24
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Abstract We previously introduced a voxel-based, multi-modal application of the partial least square algorithm (MMPLS) to characterize the linkage between patterns in a person's complementary complex datasets without the need to correct for multiple regional comparisons. Here we used it to demonstrate a strong correlation between MMPLS scores to characterize the linkage between the covarying patterns of fluorodeoxyglucose positron emission tomography (FDG PET) measurements of regional glucose metabolism and magnetic resonance imaging (MRI) measurements of regional gray matter associated with apolipoprotein E (APOE) e4 gene dose (i.e., three levels of genetic risk for late-onset Alzheimer's disease (AD)) in cognitively normal, late-middle-aged persons. Coregistered and spatially normalized FDG PET and MRI images from 70 of the subjects (27 e4 homozygotes, 36 e4 heterozygotes and 67 e4 non-carriers) were used in a hypothesis-generating MMPLS analysis to characterize the covarying pattern of regional gray matter volume and cerebral glucose metabolism most strongly correlated with APOE-e4 gene dose. Coregistered and spatially normalized FDG PET and MRI images from the remaining 30 of the subjects were used in a hypothesis-testing MMPLS analysis to generate FDG PET-MRI gray matter MMPLS scores blind to their APOE genotype and characterize their relationship to APOE-e4 gene dose. The hypothesis-generating analysis revealed covarying regional gray matter volume and cerebral glucose metabolism patterns that resembled those in traditional univariate analyses of AD and APOE-e4 gene dose and PET-MRI scores that were strongly correlated with APOE-e4 gene dose (p Many machine learning and pattern classification methods have been applied to the diagnosis of Alzheimer’s disease (AD) and its prodromal stage, i.e., mild cognitive impairment (MCI). Recently, rather than predicting categorical variables as in classification, several pattern regression methods have also been used to estimate continuous clinical variables from brain images. However, most existing regression methods focus on estimating multiple clinical variables separately and thus cannot utilize the intrinsic useful correlation information among different clinical variables. On the other hand, in those regression methods, only a single modality of data (usually only the structural MRI) is often used, without considering the complementary information that can be provided by different modalities. In this paper, we propose a general methodology, namely Multi-Modal Multi-Task (M3T) learning, to jointly predict multiple variables from multi-modal data. Here, the variables include not only the clinical variables used for regression but also the categorical variable used for classification, with different tasks corresponding to prediction of different variables. Specifically, our method contains two key components, i.e., (1) a multi-task feature selection which selects the common subset of relevant features for multiple variables from each modality, and (2) a multi-modal support vector machine which fuses the above-selected features from all modalities to predict multiple (regression and classification) variables. To validate our method, we perform two sets of experiments on ADNI baseline MRI, FDG-PET, and cerebrospinal fluid (CSF) data from 45 AD patients, 91 MCI patients, and 50 healthy controls (HC). In the first set of experiments, we estimate two clinical variables such as Mini Mental State Examination (MMSE) and Alzheimer’s Disease Assessment Scale - Cognitive Subscale (ADAS-Cog), as well as one categorical variable (with value of ‘AD’, ‘MCI’ or ‘HC’), from the baseline MRI, FDG-PET, and CSF data. In the second set of experiments, we predict the 2-year changes of MMSE and ADAS-Cog scores and also the conversion of MCI to AD from the baseline MRI, FDG-PET, and CSF data. The results on both sets of experiments demonstrate that our proposed M3T learning scheme can achieve better performance on both regression and classification tasks than the conventional learning methods. This paper presents a novel way to perform multi-modal face recognition. We use Partial Least Squares (PLS) to linearly map images in different modalities to a common linear subspace in which they are highly correlated. PLS has been previously used effectively for feature selection in face recognition. We show both theoretically and experimentally that PLS can be used effectively across modalities. We also formulate a generic intermediate subspace comparison framework for multi-modal recognition. Surprisingly, we achieve high performance using only pixel intensities as features. We experimentally demonstrate the highest published recognition rates on the pose variations in the PIE data set, and also show that PLS can be used to compare sketches to photos, and to compare images taken at different resolutions. article i nfo Partial Least Squares (PLS) methods are particularly suited to the analysis of relationships between measures of brain activity and of behavior or experimental design. In neuroimaging, PLS refers to two related methods: (1) symmetric PLS or Partial Least Squares Correlation (PLSC), and (2) asymmetric PLS or Partial Least Squares Regression (PLSR). The most popular (by far) version of PLS for neuroimaging is PLSC. It exists in several varieties based on the type of data that are related to brain activity: behavior PLSC analyzes the relationship between brain activity and behavioral data, task PLSC analyzes how brain activity relates to pre- defined categories or experimental design, seed PLSC analyzes the pattern of connectivity between brain regions, and multi-block or multi-table PLSC integrates one or more of these varieties in a common analysis. PLSR, in contrast to PLSC, is a predictive technique which, typically, predicts behavior (or design) from brain activity. For both PLS methods, statistical inferences are implemented using cross-validation techniques to identify significant patterns of voxel activation. This paper presents both PLS methods and illustrates them with small numerical examples and typical applications in neuroimaging. Segmentation of infant brain MR images is challenging due to insufficient image quality, severe partial volume effect, and the ongoing maturation and myelination processes. In particular, the image contrast inverts around 6–8 months of age, and the white and gray matter tissues are isointense in both T1- and T2-weighted MR images and thus exhibit the extremely low tissue contrast, which poses the significant challenges for automated segmentation. Most previous studies used multi-atlas label fusion strategy, which has the limitation of equally treating the available multi-modality images and is often computationally expensive. In this paper, we propose a novel learning-based multi-source integration framework for infant brain image segmentation. Specifically, we employ the random forest technique to effectively integrate features from multi-source images together for tissue segmentation. The multi-source images include initially only the multi-modality (T1, T2 and FA) images and later also the iteratively estimated and refined tissue probability maps of gray matter, white matter, and cerebrospinal fluid. Experimental results on 119 infant subjects and MICCAI challenges show that the proposed method achieves better performance than other state-of-the-art automated segmentation methods, with significantly reduction of running time from hours to 5 minutes. Although visible face recognition has been an active area of research for several decades, cross-modal face recognition has only been explored by the biometrics community relatively recently. Thermal-to-visible face recognition is one of the most difficult cross-modal face recognition challenges, because of the difference in phenomenology between the thermal and visible imaging modalities. We address the cross-modal recognition problem using a partial least squares (PLS) regression-based approach consisting of preprocessing, feature extraction, and PLS model building. The preprocessing and feature extraction stages are designed to reduce the modality gap between the thermal and visible facial signatures, and facilitate the subsequent one-vs-all PLS-based model building. We incorporate multi-modal information into the PLS model building stage to enhance cross-modal recognition. The performance of the proposed recognition algorithm is evaluated on three challenging datasets containing visible and thermal imagery acquired under different experimental scenarios: time-lapse, physical tasks, mental tasks, and subject-to-camera range. These scenarios represent difficult challenges relevant to real-world applications. We demonstrate that the proposed method performs robustly for the examined scenarios. In reality, data objects often belong to several different categories simultaneously, which are semantically correlated to each other. Multi-label learning can handle and extract useful information from such kind of data effectively. Since it has a great variety of potential applications, multi-label learning has attracted widespread attention from many domains. However, two major challenges still remain for multi-label learning: high dimensionality and correlations of data. In this paper, we address the problems by using the technique of partial least squares (PLS) and propose a new multi-label learning method called rPLSML (regularized Partial Least Squares for Multi-label Learning). Specifically, we exploit PLS discriminant analysis to identify a latent and common space from the variable and label spaces of data, and then construct a learning model based on the latent space. To tackle the multi-collinearity problem raised from the high dimensionality, a ( _2 )-norm penalty is further exerted on the optimization problem. The experimental results on public data sets show that rPLSML has better performance than the state-of-the-art multi-label learning algorithms. This paper concerns the spatial and intensity transformations that map one image onto another. We present a general technique that facilitates nonlinear spatial (stereotactic) normalization and image realignment. This technique minimizes the sum of squares between two images following nonlinear spatial deformations and transformations of the voxel (intensity) values. The spatial and intensity transformations are obtained simultaneously, and explicitly, using a least squares solution and a series of linearising devices. The approach is completely noninteractive (automatic), nonlinear, and noniterative. It can be applied in any number of dimensions. Various applications are considered, including the realignment of functional magnetic resonance imaging (MRI) time-series, the linear (affine) and nonlinear spatial normalization of positron emission tomography (PET) and structural MRI images, the coregistration of PET to structural MRI, and, implicitly, the conjoining of PET and MRI to obtain high resolution functional images. © 1995 Wiley-Liss, Inc. Imaging is a powerful tool being used in many disciplines such as engineering, physics, biology and medicine to name a few. Recent years have seen a trend that imaging modalities have been combined to create multi-modality imaging tools where different modalities acquire complementary information. For example, in medical imaging, positron emission tomography (PET) and magnetic resonance imaging (MRI) are combined to image structure and function of the human body. Another example is spectral imaging where each channel provides information about a different wave length, e.g. information about red, green and blue (RGB). Most imaging modalities do not acquire images directly but measure a quantity from which we can reconstruct an image. These inverse problems require a priori information in order to give meaningful solutions. Assumptions are often on the smoothness of the solution but other information is sometimes available, too. Many multi-modality images show a strong inter-channel correlation as they are acquired from the same anatomy in medical imaging or the same scenery in spectral imaging. However, images from different modalities are usually reconstructed separately. In this thesis we aim to exploit this correlation using the data from all modalities, that are present in the acquisition, in a joint reconstruction process with the assumption that similar structures in all channels are more likely. We propose a framework for joint reconstruction where modalities are coupled by additional information about the solution we seek. A family of priors -- called parallel level sets -- allows us to incorporate structural a priori knowledge into the reconstruction. We analyse the parallel level set priors in several aspects including their convexity and the diffusive flow generated by their variation. Several numerical examples in RGB colour imaging and in PET-MRI illustrate the gain of joint reconstruction and in particular of the parallel level set priors. This paper presents our contribution to ACM ICMI 2015 Emotion Recognition in the Wild Challenge (EmotiW 2015). We participate in both static facial expression (SFEW) and audio-visual emotion recognition challenges. In both challenges, we use a set of visual descriptors and their early and late fusion schemes. For AFEW, we also exploit a set of popularly used spatio-temporal modeling alternatives and carry out multi-modal fusion. For classification, we employ two least squares regression based learners that are shown to be fast and accurate on former EmotiW Challenge corpora. Specifically, we use Partial Least Squares Regression (PLS) and Kernel Extreme Learning Machines (ELM), which is closely related to Kernel Regularized Least Squares. We use a General Procrustes Analysis (GPA) based alignment for face registration. By employing different alignments, descriptor types, video modeling strategies and classifiers, we diversify learners to improve the final fusion performance. Test set accuracies reached in both challenges are relatively 25 above the respective baselines. This paper proposes a new approach for Cross Modal Matching, i.e. the matching of patterns represented in di erent modalities, when pairs of same di erent data are available for training (e.g. faces of same di erent persons). In this situation, standard approaches such as Partial Least Squares (PLS) or Canonical Correlation Analysis (CCA), map the data into a common latent space that maximizes the covariance, using the information brought by positive pairs only. Our contribution is a new metric learning algorithm, which alleviates this limitation by considering both positive and negative constraints and use them effi ciently to learn a discriminative latent space. The contribution is validated on several datasets for which the proposed approach consistently outperforms PLS CCA as well as more recent discriminative approaches. Combined positron emission tomography (PET) and magnetic resonance imaging (MRI) scanners acquire simultaneously functional PET and anatomical or functional MRI data. As the data of both modalities are likely to show similar structures we aim to exploit this by joint reconstruction of PET and MRI. In a Bayesian formulation, this can be achieved by adding prior information encoding that the images of the two modalities are not independent. Structural similarity can be modeled by the alignment of the image gradients or equivalently their level sets being parallel. Therefore we can combine the objective functions of both modalities and penalize image pairs which do not have parallel level sets. Our results show that combining the reconstruction from heavily under-sampled MRI and noisy PET data can lead to less under-sampling artifacts in MRI images and better defined PET images. Multi-modal sparse coding has played an important role in many multimedia applications, where data are usually with multiple modalities. Recently, various multi-modal sparse coding approaches have been proposed to learn sparse codes of multi-modal data, which assume that data appear in all modalities, or at least there is one modality containing all data. However, in real applications, it is often the case that some modalities of the data may suffer from missing information and thus result in partial multi-modality data. In this paper, we propose to solve the partial multi-modal sparse coding problem via multi-modal similarity structure regularization. Specifically, we propose a partial multi-modal sparse coding framework termed Adaptive Partial Multi-Modal Similarity Structure Regularization for Sparse Coding (AdaPM2SC), which preserves the similarity structure within the same modality and between different modalities. Experimental results conducted on two real-world datasets demonstrate that AdaPM2SC significantly outperforms the state-of-the-art methods under partial multi-modality scenario. Abstract In this paper, we present a novel automated method for White Matter (WM) lesion segmentation of Multiple Sclerosis (MS) patient images. Our approach is based on a cascade of two 3D patch-wise convolutional neural networks (CNN). The first network is trained to be more sensitive revealing possible candidate lesion voxels while the second network is trained to reduce the number of misclassified voxels coming from the first network. This cascaded CNN architecture tends to learn well from a small ( n ≤ 35 ) set of labeled data of the same MRI contrast, which can be very interesting in practice, given the difficulty to obtain manual label annotations and the large amount of available unlabeled Magnetic Resonance Imaging (MRI) data. We evaluate the accuracy of the proposed method on the public MS lesion segmentation challenge MICCAI2008 dataset, comparing it with respect to other state-of-the-art MS lesion segmentation tools. Furthermore, the proposed method is also evaluated on two private MS clinical datasets, where the performance of our method is also compared with different recent public available state-of-the-art MS lesion segmentation methods. At the time of writing this paper, our method is the best ranked approach on the MICCAI2008 challenge, outperforming the rest of 60 participant methods when using all the available input modalities (T1-w, T2-w and FLAIR), while still in the top-rank (3rd position) when using only T1-w and FLAIR modalities. On clinical MS data, our approach exhibits a significant increase in the accuracy segmenting of WM lesions when compared with the rest of evaluated methods, highly correlating ( r ≥ 0.97 ) also with the expected lesion volume. ObjectiveWe have previously reported an automated method for within-modality (e.g., PET-to-PET) image alignment. We now describe modifications to this method that allow for cross-modality registration of MRI and PET brain images obtained from a single subject.MethodsThis method does not require fidu In this paper, the problem of multi-view embedding from different visual cues and modalities is considered. We propose a unified solution for subspace learning methods using the Rayleigh quotient, which is extensible for multiple views, supervised learning, and nonlinear embeddings. Numerous methods including canonical correlation analysis, partial least square regression, and linear discriminant analysis are studied using specific intrinsic and penalty graphs within the same framework. Nonlinear extensions based on kernels and (deep) neural networks are derived, achieving better performance than the linear ones. Moreover, a novel multi-view modular discriminant analysis is proposed by taking the view difference into consideration. We demonstrate the effectiveness of the proposed multi-view embedding methods on visual object recognition and cross-modal image retrieval, and obtain superior results in both applications compared to related methods. Advances in neonatal care have improved the survival of infants born prematurely although these infants remain at increased risk of adverse neurodevelopmental outcome. The measurement of white matter structure and features of the cortical surface can help define biomarkers that predict this risk. The measurement of these structures relies upon accurate automated segmentation routines, but these are often confounded by neonatal-specific imaging difficulties including poor contrast, low resolution, partial volume effects and the presence of significant natural and pathological anatomical variability. In this work we develop and evaluate an adaptive preterm multi-modal maximum a posteriori expectation-maximisation segmentation algorithm (AdaPT) incorporating an iterative relaxation strategy that adapts the tissue proportion priors toward the subject data. Also incorporated are intensity non-uniformity correction, a spatial homogeneity term in the form of a Markov random field and furthermore, the proposed method explicitly models the partial volume effect specifically mitigating the neonatal specific grey and white matter contrast inversion. Spatial priors are iteratively relaxed, enabling the segmentation of images with high anatomical disparity from a normal population. Experiments performed on a clinical cohort of 92 infants are validated against manual segmentation of normal and pathological cortical grey matter, cerebellum and ventricular volumes. Dice overlap scores increase significantly when compared to a widely-used maximum likelihood expectation maximisation algorithm for pathological cortical grey matter, cerebellum and ventricular volumes. Adaptive maximum a posteriori expectation maximisation is shown to be a useful tool for accurate and robust neonatal brain segmentation. Multi-modal image registration is a challenging problem in medical imaging. The goal is to align anatomically identical structures; however, their appearance in images acquired with different imaging devices, such as CT or MR, may be very different. Registration algorithms generally deform one image, the floating image, such that it matches with a second, the reference image, by maximizing some similarity score between the deformed and the reference image. Instead of using a universal, but a priori fixed similarity criterion such as mutual information, we propose learning a similarity measure in a discriminative manner such that the reference and correctly deformed floating images receive high similarity scores. To this end, we develop an algorithm derived from max-margin structured output learning, and employ the learned similarity measure within a standard rigid registration algorithm. Compared to other approaches, our method adapts to the specific registration problem at hand and exploits correlations between neighboring pixels in the reference and the floating image. Empirical evaluation on CT-MR PET-MR rigid registration tasks demonstrates that our approach yields robust performance and outperforms the state of the art methods for multi-modal medical image registration. The segmentation of infant brain tissue images into white matter (WM), gray matter (GM), and cerebrospinal fluid (CSF) plays an important role in studying early brain development. In the isointense phase (approximately 6–8 months of age), WM and GM exhibit similar levels of intensity in both T1 and T2 MR images, resulting in extremely low tissue contrast and thus making the tissue segmentation very challenging. The existing methods for tissue segmentation in this isointense phase usually employ patch-based sparse labeling on single T1, T2 or fractional anisotropy (FA) modality or their simply-stacked combinations without fully exploring the multi-modality information. To address the challenge, in this paper, we propose to use fully convolutional networks (FCNs) for the segmentation of isointense phase brain MR images. Instead of simply stacking the three modalities, we train one network for each modality image, and then fuse their high-layer features together for final segmentation. Specifically, we conduct a convolution-pooling stream for multimodality information from T1, T2, and FA images separately, and then combine them in high-layer for finally generating the segmentation maps as the outputs. We compared the performance of our approach with that of the commonly used segmentation methods on a set of manually segmented isointense phase brain images. Results showed that our proposed model significantly outperformed previous methods in terms of accuracy. In addition, our results also indicated a better way of integrating multi-modality images, which leads to performance improvement. Recent advances in technology have enabled the combination of positron emission tomography (PET) with magnetic resonance imaging (MRI). These PET-MRI scanners simultaneously acquire functional PET and anatomical or functional MRI data. As function and anatomy are not independent of one another the images to be reconstructed are likely to have shared structures. We aim to exploit this inherent structural similarity by reconstructing from both modalities in a joint reconstruction framework. The structural similarity between two modalities can be modelled in two different ways: edges are more likely to be at similar positions and or to have similar orientations. We analyse the diffusion process generated by minimizing priors that encapsulate these different models. It turns out that the class of parallel level set priors always corresponds to anisotropic diffusion which is sometimes forward and sometimes backward diffusion. We perform numerical experiments where we jointly reconstruct from blurred Radon data with Poisson noise (PET) and under-sampled Fourier data with Gaussian noise (MRI). Our results show that both modalities benefit from each other in areas of shared edge information. The joint reconstructions have less artefacts and sharper edges compared to separate reconstructions and the l2-error can be reduced in all of the considered cases of under-sampling.