Multi-organ segmentation is a critical problem in medical image analysis due to its great value for computer-aided diagnosis, computer-aided surgery, and radiation therapy. Although fully-supervised segmentation methods can achieve good performance, they usually require a large amount of 3D data, such as CT scans, with voxel-wised annotations which are usually difficult, expensive, and slow to obtain. By contrast, large unannotated datasets of CT images are available. Inspired by the well-known semi-supervised learning framework co-training, we propose multi-planar co-training (MPCT), to generate more reliable pseudo-labels by enforcing consistency among multiple planes, i.e., saggital, coronal, and axial planes, of 3D unlabeled medical data, which play a vital role in our framework. Empirical results show that generating pseudo-labels by the multi-planar fusion rather than a single plane leads to a significant performance gain. We evaluate our approach on a new collected dataset and show that MPCT boosts the performance of a typical segmentation model, fully convolutional networks, by a large margin, when only a small set of labeled 3D data is available, i.e., 77.49 vs. 73.14 .
Graph-based semi-supervised methods define a graph where the nodes are labeled and unlabeled examples in the dataset, and edges reflect the similarity of examples. These methods have been widely adopted in non-deep-learning based semi-supervised learning algorithms in the biomedical imaging domain @cite_26 @cite_46 @cite_42 .
@cite_46 @cite_26 @cite_42
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Semi-supervised learning is becoming increasingly important because it can combine data carefully labeled by humans with abundant unlabeled data to train deep neural networks. Classic methods on semi-supervised learning that have focused on transductive learning have not been fully exploited in the inductive framework followed by modern deep learning. The same holds for the manifold assumption---that similar examples should get the same prediction. In this work, we employ a transductive label propagation method that is based on the manifold assumption to make predictions on the entire dataset and use these predictions to generate pseudo-labels for the unlabeled data and train a deep neural network. At the core of the transductive method lies a nearest neighbor graph of the dataset that we create based on the embeddings of the same network.Therefore our learning process iterates between these two steps. We improve performance on several datasets especially in the few labels regime and show that our work is complementary to current state of the art. Multi-label learning refers to the problems where an instance can be assigned to more than one category. In this paper, we present a novel Semi-supervised algorithm for Multi-label learning by solving a Sylvester Equation (SMSE). Two graphs are first constructed on instance level and category level respectively. For instance level, a graph is defined based on both labeled and unlabeled instances, where each node represents one instance and each edge weight reflects the similarity between corresponding pairwise instances. Similarly, for category level, a graph is also built based on all the categories, where each node represents one category and each edge weight reflects the similarity between corresponding pairwise categories. A regularization framework combining two regularization terms for the two graphs is suggested. The regularization term for instance graph measures the smoothness of the labels of instances, and the regularization term for category graph measures the smoothness of the labels of categories. We show that the labels of unlabeled data finally can be obtained by solving a Sylvester Equation. Experiments on RCV1 data set show that SMSE can make full use of the unlabeled data information as well as the correlations among categories and achieve good performance. In addition, we give a SMSE’s extended application on collaborative filtering. In many domain adaption formulations, it is assumed to have large amount of unlabeled data from the domain of interest (target domain), some portion of it may be labeled, and large amount of labeled data from other domains, also known as source domain(s). Motivated by the fact that labeled data is hard to obtain in any domain, we design algorithms for the settings in which there exists large amount of unlabeled data from all domains, small portion of which may be labeled. We build on recent advances in graph-based semi-supervised learning and supervised metric learning. Given all instances, labeled and unlabeled, from all domains, we build a large similarity graph between them, where an edge exists between two instances if they are close according to some metric. Instead of using predefined metric, as commonly performed, we feed the labeled instances into metric-learning algorithms and (re)construct a data-dependent metric, which is used to construct the graph. We employ different types of edges depending on the domain-identity of the two vertices touching it, and learn the weights of each edge. Experimental results show that our approach leads to significant reduction in classification error across domains, and performs better than two state-of-the-art models on the task of sentiment classification. In the literature, most existing graph-based semi-supervised learning methods only use the label information of observed samples in the label propagation stage, while ignoring such valuable information when learning the graph. In this paper, we argue that it is beneficial to consider the label information in the graph learning stage. Specifically, by enforcing the weight of edges between labeled samples of different classes to be zero, we explicitly incorporate the label information into the state-of-the-art graph learning methods, such as the low-rank representation (LRR), and propose a novel semi-supervised graph learning method called semi-supervised low-rank representation. This results in a convex optimization problem with linear constraints, which can be solved by the linearized alternating direction method. Though we take LRR as an example, our proposed method is in fact very general and can be applied to any self-representation graph learning methods. Experiment results on both synthetic and real data sets demonstrate that the proposed graph learning method can better capture the global geometric structure of the data, and therefore is more effective for semi-supervised learning tasks. We present a graph-based semi-supervised learning algorithm to address the sentiment analysis task of rating inference. Given a set of documents (e.g., movie reviews) and accompanying ratings (e.g., "4 stars"), the task calls for inferring numerical ratings for unlabeled documents based on the perceived sentiment expressed by their text. In particular, we are interested in the situation where labeled data is scarce. We place this task in the semi-supervised setting and demonstrate that considering unlabeled reviews in the learning process can improve rating-inference performance. We do so by creating a graph on both labeled and unlabeled data to encode certain assumptions for this task. We then solve an optimization problem to obtain a smooth rating function over the whole graph. When only limited labeled data is available, this method achieves significantly better predictive accuracy over other methods that ignore the unlabeled examples during training. The lack of labeled data always poses challenges for tasks where machine learning is involved. Semi-supervised and cross-domain approaches represent the most common ways to overcome this difficulty. Graph-based algorithms have been widely studied during the last decade and have proved to be very effective at solving the data limitation problem. This paper explores one of the most popular stateof-the-art graph-based algorithms - label propagation, together with its modifications previously applied to sentiment classification. We study the impact of modified graph structure and parameter variations and compare the performance of graph-based algorithms in cross-domain and semi-supervised settings. The results provide a strategy for selecting the most favourable algorithm and learning paradigm on the basis of the available labeled and unlabeled data. We propose a family of learning algorithms based on a new form of regularization that allows us to exploit the geometry of the marginal distribution. We focus on a semi-supervised framework that incorporates labeled and unlabeled data in a general-purpose learner. Some transductive graph learning algorithms and standard methods including support vector machines and regularized least squares can be obtained as special cases. We use properties of reproducing kernel Hilbert spaces to prove new Representer theorems that provide theoretical basis for the algorithms. As a result (in contrast to purely graph-based approaches) we obtain a natural out-of-sample extension to novel examples and so are able to handle both transductive and truly semi-supervised settings. We present experimental evidence suggesting that our semi-supervised algorithms are able to use unlabeled data effectively. Finally we have a brief discussion of unsupervised and fully supervised learning within our general framework. Learning rich visual representations often require training on datasets of millions of manually annotated examples. This substantially limits the scalability of learning effective representations as labeled data is expensive or scarce. In this paper, we address the problem of unsupervised visual representation learning from a large, unlabeled collection of images. By representing each image as a node and each nearest-neighbor matching pair as an edge, our key idea is to leverage graph-based analysis to discover positive and negative image pairs (i.e., pairs belonging to the same and different visual categories). Specifically, we propose to use a cycle consistency criterion for mining positive pairs and geodesic distance in the graph for hard negative mining. We show that the mined positive and negative image pairs can provide accurate supervisory signals for learning effective representations using Convolutional Neural Networks (CNNs). We demonstrate the effectiveness of the proposed unsupervised constraint mining method in two settings: (1) unsupervised feature learning and (2) semi-supervised learning. For unsupervised feature learning, we obtain competitive performance with several state-of-the-art approaches on the PASCAL VOC 2007 dataset. For semi-supervised learning, we show boosted performance by incorporating the mined constraints on three image classification datasets. Semi-supervised learning algorithms reduce the high cost of acquiring labeled training data by using both labeled and unlabeled data during learning. Deep Convolutional Networks (DCNs) have achieved great success in supervised tasks and as such have been widely employed in the semi-supervised learning. In this paper we leverage the recently developed Deep Rendering Mixture Model (DRMM), a probabilistic generative model that models latent nuisance variation, and whose inference algorithm yields DCNs. We develop an EM algorithm for the DRMM to learn from both labeled and unlabeled data. Guided by the theory of the DRMM, we introduce a novel non-negativity constraint and a variational inference term. We report state-of-the-art performance on MNIST and SVHN and competitive results on CIFAR10. We also probe deeper into how a DRMM trained in a semi-supervised setting represents latent nuisance variation using synthetically rendered images. Taken together, our work provides a unified framework for supervised, unsupervised, and semi-supervised learning. Semi-supervised learning, which uses unlabeled data to help learn a discriminative model, is especially important for structured output problems, as considerably more effort is needed to label its multi-dimensional outputs versus standard single output problems. We propose a new max-margin framework for semi-supervised structured output learning, that allows the use of powerful discrete optimization algorithms and high order regularizers defined directly on model predictions for the unlabeled examples. We show that our framework is closely related to Posterior Regularization, and the two frameworks optimize special cases of the same objective. The new framework is instantiated on two image segmentation tasks, using both a graph regularizer and a cardinality regularizer. Experiments also demonstrate that this framework can utilize unlabeled data from a different source than the labeled data to significantly improve performance while saving labeling effort. This paper presents a novel semi-supervised learning algorithm called Active Deep Networks (ADN), to address the semi-supervised sentiment classification problem with active learning. First, we propose the semi-supervised learning method of ADN. ADN is constructed by Restricted Boltzmann Machines (RBM) with unsupervised learning using labeled data and abundant of unlabeled data. Then the constructed structure is fine-tuned by gradient-descent based supervised learning with an exponential loss function. Second, we apply active learning in the semi-supervised learning framework to identify reviews that should be labeled as training data. Then ADN architecture is trained by the selected labeled data and all unlabeled data. Experiments on five sentiment classification datasets show that ADN outperforms the semi-supervised learning algorithm and deep learning techniques applied for sentiment classification. In many practical data mining applications such as text classification, unlabeled training examples are readily available, but labeled ones are fairly expensive to obtain. Therefore, semi supervised learning algorithms have aroused considerable interests from the data mining and machine learning fields. In recent years, graph-based semi supervised learning has been becoming one of the most active research areas in the semi supervised learning community. In this paper, a novel graph-based semi supervised learning approach is proposed based on a linear neighborhood model, which assumes that each data point can be linearly reconstructed from its neighborhood. Our algorithm, named linear neighborhood propagation (LNP), can propagate the labels from the labeled points to the whole data set using these linear neighborhoods with sufficient smoothness. A theoretical analysis of the properties of LNP is presented in this paper. Furthermore, we also derive an easy way to extend LNP to out-of-sample data. Promising experimental results are presented for synthetic data, digit, and text classification tasks. The recently proposed self-ensembling methods have achieved promising results in deep semi-supervised learning, which penalize inconsistent predictions of unlabeled data under different perturbations. However, they only consider adding perturbations to each single data point, while ignoring the connections between data samples. In this paper, we propose a novel method, called Smooth Neighbors on Teacher Graphs (SNTG). In SNTG, a graph is constructed based on the predictions of the teacher model, i.e., the implicit self-ensemble of models. Then the graph serves as a similarity measure with respect to which the representations of "similar" neighboring points are learned to be smooth on the low-dimensional manifold. We achieve state-of-the-art results on semi-supervised learning benchmarks. The error rates are 9.89 , 3.99 for CIFAR-10 with 4000 labels, SVHN with 500 labels, respectively. In particular, the improvements are significant when the labels are fewer. For the non-augmented MNIST with only 20 labels, the error rate is reduced from previous 4.81 to 1.36 . Our method also shows robustness to noisy labels. In traditional machine learning approaches to classification, one uses only a labeled set to train the classifier. Labeled instances however are often difficult, expensive, or time consuming to obtain, as they require the efforts of experienced human annotators. Meanwhile unlabeled data may be relatively easy to collect, but there has been few ways to use them. Semi-supervised learning addresses this problem by using large amount of unlabeled data, together with the labeled data, to build better classifiers. Because semi-supervised learning requires less human effort and gives higher accuracy, it is of great interest both in theory and in practice. We present a series of novel semi-supervised learning approaches arising from a graph representation, where labeled and unlabeled instances are represented as vertices, and edges encode the similarity between instances. They address the following questions: How to use unlabeled data? (label propagation); What is the probabilistic interpretation? (Gaussian fields and harmonic functions); What if we can choose labeled data? (active learning); How to construct good graphs? (hyperparameter learning); How to work with kernel machines like SVM? (graph kernels); How to handle complex data like sequences? (kernel conditional random fields); How to handle scalability and induction? (harmonic mixtures). An extensive literature review is included at the end. Semi-supervised learning is a learning paradigm concerned with the study of how computers and natural systems such as humans learn in the presence of both labeled and unlabeled data. Traditionally, learning has been studied either in the unsupervised paradigm (e.g., clustering, outlier detection) where all the data is unlabeled, or in the supervised paradigm (e.g., classification, regression) where all the data is labeled.The goal of semi-supervised learning is to understand how combining labeled and unlabeled data may change the learning behavior, and design algorithms that take advantage of such a combination. Semi-supervised learning is of great interest in machine learning and data mining because it can use readily available unlabeled data to improve supervised learning tasks when the labeled data is scarce or expensive. Semi-supervised learning also shows potential as a quantitative tool to understand human category learning, where most of the input is self-evidently unlabeled. In this introductory book, we present some popular semi-supervised learning models, including self-training, mixture models, co-training and multiview learning, graph-based methods, and semi-supervised support vector machines. For each model, we discuss its basic mathematical formulation. The success of semi-supervised learning depends critically on some underlying assumptions. We emphasize the assumptions made by each model and give counterexamples when appropriate to demonstrate the limitations of the different models. In addition, we discuss semi-supervised learning for cognitive psychology. Finally, we give a computational learning theoretic perspective on semi-supervised learning, and we conclude the book with a brief discussion of open questions in the field. Insufficiency of labeled training data is a major obstacle for automatically annotating large-scale video databases with semantic concepts. Existing semi-supervised learning algorithms based on parametric models try to tackle this issue by incorporating the information in a large amount of unlabeled data. However, they are based on a "model assumption" that the assumed generative model is correct, which usually cannot be satisfied in automatic video annotation due to the large variations of video semantic concepts. In this paper, we propose a novel semi-supervised learning algorithm, named Semi Supervised Learning by Kernel Density Estimation (SSLKDE), which is based on a non-parametric method, and therefore the "model assumption" is avoided. While only labeled data are utilized in the classical Kernel Density Estimation (KDE) approach, in SSLKDE both labeled and unlabeled data are leveraged to estimate class conditional probability densities based on an extended form of KDE. We also investigate the connection between SSLKDE and existing graph-based semi-supervised learning algorithms. Experiments prove that SSLKDE significantly outperforms existing supervised methods for video annotation. Shortage of manually sense-tagged data is an obstacle to supervised word sense disambiguation methods. In this paper we investigate a label propagation based semi-supervised learning algorithm for WSD, which combines labeled and unlabeled data in learning process to fully realize a global consistency assumption: similar examples should have similar labels. Our experimental results on benchmark corpora indicate that it consistently outperforms SVM when only very few labeled examples are available, and its performance is also better than monolingual bootstrapping, and comparable to bilingual bootstrapping. This work addresses graph-based semi-supervised classification and betweenness computation in large, sparse, networks (several millions of nodes). The objective of semi-supervised classification is to assign a label to unlabeled nodes using the whole topology of the graph and the labeling at our disposal. Two approaches are developed to avoid explicit computation of pairwise proximity between the nodes of the graph, which would be impractical for graphs containing millions of nodes. The first approach directly computes, for each class, the sum of the similarities between the nodes to classify and the labeled nodes of the class, as suggested initially in [1,2]. Along this approach, two algorithms exploiting different state-of-the-art kernels on a graph are developed. The same strategy can also be used in order to compute a betweenness measure. The second approach works on a trellis structure built from biased random walks on the graph, extending an idea introduced in [3]. These random walks allow to define a biased bounded betweenness for the nodes of interest, defined separately for each class. All the proposed algorithms have a linear computing time in the number of edges while providing good results, and hence are applicable to large sparse networks. They are empirically validated on medium-size standard data sets and are shown to be competitive with state-of-the-art techniques. Finally, we processed a novel data set, which is made available for benchmarking, for multi-class classification in a large network: the U.S. patents citation network containing 3M nodes (of six different classes) and 38M edges. The three proposed algorithms achieve competitive results (around 85 classification rate) on this large network-they classify the unlabeled nodes within a few minutes on a standard workstation. Probability distributions and histograms are natural representations for product ratings, traffic measurements, and other data considered in many machine learning applications. Thus, this paper introduces a technique for graph-based semi-supervised learning of histograms, derived from the theory of optimal transportation. Our method has several properties making it suitable for this application; in particular, its behavior can be characterized by the moments and shapes of the histograms at the labeled nodes. In addition, it can be used for histograms on non-standard domains like circles, revealing a strategy for manifold-valued semi-supervised learning. We also extend this technique to related problems such as smoothing distributions on graph nodes. Due to its wide applicability, the problem of semi-supervised classification is attracting increasing attention in machine learning. Semi-Supervised Support Vector Machines (S3VMs) are based on applying the margin maximization principle to both labeled and unlabeled examples. Unlike SVMs, their formulation leads to a non-convex optimization problem. A suite of algorithms have recently been proposed for solving S3VMs. This paper reviews key ideas in this literature. The performance and behavior of various S3VMs algorithms is studied together, under a common experimental setting.