In recent years, with the popularization of deep learning frameworks and large datasets, researchers have started parallelizing their models in order to train faster. This is crucially important, because they typically explore many hyperparameters in order to find the best ones for their applications. This process is time consuming and, consequently, speeding up training improves productivity. One approach to parallelize deep learning models followed by many researchers is based on weak scaling. The minibatches increase in size as new GPUs are added to the system. In addition, new learning rates schedules have been proposed to fix optimization issues that occur with large minibatch sizes. In this paper, however, we show that the recommendations provided by recent work do not apply to models that lack large datasets. In fact, we argument in favor of using strong scaling for achieving reliable performance in such cases. We evaluated our approach with up to 32 GPUs and show that weak scaling not only does not have the same accuracy as the sequential model, it also fails to converge most of time. Meanwhile, strong scaling has good scalability while having exactly the same accuracy of a sequential implementation.
In medical imaging, the current state-of-art for classification and segmentation of 3D exams are 3D deep learning models @cite_15 . However, the widely known computational burden of such models due to 3D convolutions, in many times hinders the development of real-time systems for aiding in the diagnosis of 3D exams. This creates opportunities for methods that aim at providing time-efficient support to process 3D models in parallel.
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Automatic liver segmentation from CT volumes is a crucial prerequisite yet challenging task for computer-aided hepatic disease diagnosis and treatment. In this paper, we present a novel 3D deeply supervised network (3D DSN) to address this challenging task. The proposed 3D DSN takes advantage of a fully convolutional architecture which performs efficient end-to-end learning and inference. More importantly, we introduce a deep supervision mechanism during the learning process to combat potential optimization difficulties, and thus the model can acquire a much faster convergence rate and more powerful discrimination capability. On top of the high-quality score map produced by the 3D DSN, a conditional random field model is further employed to obtain refined segmentation results. We evaluated our framework on the public MICCAI-SLiver07 dataset. Extensive experiments demonstrated that our method achieves competitive segmentation results to state-of-the-art approaches with a much faster processing speed. Medical imaging has advanced enormously over the last few decades, revolutionizing patient diagnostics and care. At the same time, additive manufacturing has emerged as a means of reproducing physical shapes and models previously not possible. In combination, they have given rise to 3-dimensional (3D) modeling, an entirely new technology for physicians. In an era in which 3D imaging has become a standard for aiding in the diagnosis and treatment of cardiac disease, this visualization now can be taken further by bringing the patient’s anatomy into physical reality as a model. The authors describe the generalized process of creating a model of cardiac anatomy from patient images and their experience creating patient-specific dynamic mitral valve models. This involves a combination of image processing software and 3D printing technology. In this article, the complexity of 3D modeling is described and the decision-making process for cardiac anesthesiologists is summarized. The management of cardiac disease has been altered with the emergence of 3D echocardiography, and 3D modeling represents the next paradigm shift. While deep convolutional neural networks (CNNs) have achieved remarkable success in 2D medical image segmentation, it is still a difficult task for CNNs to segment important organs or structures from 3D medical images owing to several mutually affected challenges, including the complicated anatomical environments in volumetric images, optimization difficulties of 3D networks and inadequacy of training samples. In this paper, we present a novel and efficient 3D fully convolutional network equipped with a 3D deep supervision mechanism to comprehensively address these challenges; we call it 3D DSN. Our proposed 3D DSN is capable of conducting volume-to-volume learning and inference, which can eliminate redundant computations and alleviate the risk of over-fitting on limited training data. More importantly, the 3D deep supervision mechanism can effectively cope with the optimization problem of gradients vanishing or exploding when training a 3D deep model, accelerating the convergence speed and simultaneously improving the discrimination capability. Such a mechanism is developed by deriving an objective function that directly guides the training of both lower and upper layers in the network, so that the adverse effects of unstable gradient changes can be counteracted during the training procedure. We also employ a fully connected conditional random field model as a post-processing step to refine the segmentation results. We have extensively validated the proposed 3D DSN on two typical yet challenging volumetric medical image segmentation tasks: (i) liver segmentation from 3D CT scans and (ii) whole heart and great vessels segmentation from 3D MR images, by participating two grand challenges held in conjunction with MICCAI. We have achieved competitive segmentation results to state-of-the-art approaches in both challenges with a much faster speed, corroborating the effectiveness of our proposed 3D DSN. Multi-organ segmentation is a critical problem in medical image analysis due to its great value for computer-aided diagnosis, computer-aided surgery, and radiation therapy. Although fully-supervised segmentation methods can achieve good performance, they usually require a large amount of 3D data, such as CT scans, with voxel-wised annotations which are usually difficult, expensive, and slow to obtain. By contrast, large unannotated datasets of CT images are available. Inspired by the well-known semi-supervised learning framework co-training, we propose multi-planar co-training (MPCT), to generate more reliable pseudo-labels by enforcing consistency among multiple planes, i.e., saggital, coronal, and axial planes, of 3D unlabeled medical data, which play a vital role in our framework. Empirical results show that generating pseudo-labels by the multi-planar fusion rather than a single plane leads to a significant performance gain. We evaluate our approach on a new collected dataset and show that MPCT boosts the performance of a typical segmentation model, fully convolutional networks, by a large margin, when only a small set of labeled 3D data is available, i.e., 77.49 vs. 73.14 . Alterations in the geometry and function of the heart define well-established causes of cardiovascular disease. However, current approaches to the diagnosis of cardiovascular diseases often rely on subjective human assessment as well as manual analysis of medical images. Both factors limit the sensitivity in quantifying complex structural and functional phenotypes. Deep learning approaches have recently achieved success for tasks such as classification or segmentation of medical images, but lack interpretability in the feature extraction and decision processes, limiting their value in clinical diagnosis. In this work, we propose a 3D convolutional generative model for automatic classification of images from patients with cardiac diseases associated with structural remodeling. The model leverages interpretable task-specific anatomic patterns learned from 3D segmentations. It further allows to visualise and quantify the learned pathology-specific remodeling patterns in the original input space of the images. This approach yields high accuracy in the categorization of healthy and hypertrophic cardiomyopathy subjects when tested on unseen MR images from our own multi-centre dataset (100 ) as well on the ACDC MICCAI 2017 dataset (90 ). We believe that the proposed deep learning approach is a promising step towards the development of interpretable classifiers for the medical imaging domain, which may help clinicians to improve diagnostic accuracy and enhance patient risk-stratification. Automatic liver segmentation in 3D medical images is essential in many clinical applications, such as pathological diagnosis of hepatic diseases, surgical planning, and postoperative assessment. However, it is still a very challenging task due to the complex background, fuzzy boundary, and various appearance of liver. In this paper, we propose an automatic and efficient algorithm to segment liver from 3D CT volumes. A deep image-to-image network (DI2IN) is first deployed to generate the liver segmentation, employing a convolutional encoder-decoder architecture combined with multi-level feature concatenation and deep supervision. Then an adversarial network is utilized during training process to discriminate the output of DI2IN from ground truth, which further boosts the performance of DI2IN. The proposed method is trained on an annotated dataset of 1000 CT volumes with various different scanning protocols (e.g., contrast and non-contrast, various resolution and position) and large variations in populations (e.g., ages and pathology). Our approach outperforms the state-of-the-art solutions in terms of segmentation accuracy and computing efficiency. In this paper, we adopt 3D Convolutional Neural Networks to segment volumetric medical images. Although deep neural networks have been proven to be very effective on many 2D vision tasks, it is still challenging to apply them to 3D tasks due to the limited amount of annotated 3D data and limited computational resources. We propose a novel 3D-based coarse-to-fine framework to effectively and efficiently tackle these challenges. The proposed 3D-based framework outperforms the 2D counterpart to a large margin since it can leverage the rich spatial infor- mation along all three axes. We conduct experiments on two datasets which include healthy and pathological pancreases respectively, and achieve the current state-of-the-art in terms of Dice-S rensen Coefficient (DSC). On the NIH pancreas segmentation dataset, we outperform the previous best by an average of over 2 , and the worst case is improved by 7 to reach almost 70 , which indicates the reliability of our framework in clinical applications. Semantic parsing of large-scale 3D point clouds is an important research topic in computer vision and remote sensing fields. Most existing approaches utilize hand-crafted features for each modality independently and combine them in a heuristic manner. They often fail to consider the consistency and complementary information among features adequately, which makes them difficult to capture high-level semantic structures. The features learned by most of the current deep learning methods can obtain high-quality image classification results. However, these methods are hard to be applied to recognize 3D point clouds due to unorganized distribution and various point density of data. In this paper, we propose a 3DCNN-DQN-RNN method which fuses the 3D convolutional neural network (CNN), Deep Q-Network (DQN) and Residual recurrent neural network (RNN)for an efficient semantic parsing of large-scale 3D point clouds. In our method, an eye window under control of the 3D CNN and DQN can localize and segment the points of the object's class efficiently. The 3D CNN and Residual RNN further extract robust and discriminative features of the points in the eye window, and thus greatly enhance the parsing accuracy of large-scale point clouds. Our method provides an automatic process that maps the raw data to the classification results. It also integrates object localization, segmentation and classification into one framework. Experimental results demonstrate that the proposed method outperforms the state-of-the-art point cloud classification methods. Automatic segmentation of the liver and its lesion is an important step towards deriving quantitative biomarkers for accurate clinical diagnosis and computer-aided decision support systems. This paper presents a method to automatically segment liver and lesions in CT abdomen images using cascaded fully convolutional neural networks (CFCNs) and dense 3D conditional random fields (CRFs). We train and cascade two FCNs for a combined segmentation of the liver and its lesions. In the first step, we train a FCN to segment the liver as ROI input for a second FCN. The second FCN solely segments lesions from the predicted liver ROIs of step 1. We refine the segmentations of the CFCN using a dense 3D CRF that accounts for both spatial coherence and appearance. CFCN models were trained in a 2-fold cross-validation on the abdominal CT dataset 3DIRCAD comprising 15 hepatic tumor volumes. Our results show that CFCN-based semantic liver and lesion segmentation achieves Dice scores over (94 , ) for liver with computation times below 100 s per volume. We experimentally demonstrate the robustness of the proposed method as a decision support system with a high accuracy and speed for usage in daily clinical routine. This paper proposes RIU-Net (for Range-Image U-Net), the adaptation of a popular semantic segmentation network for the semantic segmentation of a 3D LiDAR point cloud. The point cloud is turned into a 2D range-image by exploiting the topology of the sensor. This image is then used as input to a U-net. This architecture has already proved its efficiency for the task of semantic segmentation of medical images. We demonstrate how it can also be used for the accurate semantic segmentation of a 3D LiDAR point cloud and how it represents a valid bridge between image processing and 3D point cloud processing. Our model is trained on range-images built from KITTI 3D object detection dataset. Experiments show that RIU-Net, despite being very simple, offers results that are comparable to the state-of-the-art of range-image based methods. Finally, we demonstrate that this architecture is able to operate at 90fps on a single GPU, which enables deployment for real-time segmentation. Accurate localization and segmentation of intervertebral discs (IVDs) from volumetric data is a pre-requisite for clinical diagnosis and treatment planning. With the advance of deep learning, 2D fully convolutional networks (FCN) have achieved state-of-the-art performance on 2D image segmentation related tasks. However, how to segment objects such as IVDs from volumetric data hasn’t been well addressed so far. In order to resolve above problem, we extend the 2D FCN into a 3D variant with end-to-end learning and inference, where voxel-wise predictions are generated. In order to compare the performance of 2D and 3D deep learning methods on volumetric segmentation, two different frameworks are studied: one is a 2D FCN with deep feature representations by making use of adjacent slices, the other one is a 3D FCN with flexible 3D convolutional kernels. We evaluated our methods on the 3D MRI data of MICCAI 2015 Challenge on Automatic Intervertebral Disc Localization and Segmentation. Extensive experimental results corroborated that 3D FCN can achieve a higher localization and segmentation accuracy than 2D FCN, which demonstrates the significance of volumetric information when confronting 3D localization and segmentation tasks. Lung nodule segmentation is one of the most significant steps in many Computer Aided Detection (CAD) systems used for lung nodule identification and classification. Three-dimensional convolutional neural networks (3D CNNs) have become a promising method in lung nodule segmentation, as this method can achieve higher detection accuracy than conventional methods. It has been proven that FPGAs can provide the most energy-efficient solution for CNN acceleration. However, the high computational complexity and memory requirements of 3D CNNs make it challenging to accelerate 3D CNNs on a single FPGA, as this will further bottleneck the performance of a 3D CNN-based CAD system. Accordingly, in this work, we focus on accelerating the 3D CNN-based lung nodule segmentation on a multi-FPGA platform by proposing an efficient mapping scheme that takes advantage of the massive parallelism provided by the platform, as well as maximizing the computational efficiency of the accelerators. Experimental results show that our system is able to achieve high computational efficiency and thereby a state-of-the-art performance of 14.5 TOPS at 200 MHz. Comparisons with CPU and GPU solutions demonstrate that our system achieves a 29.4x performance gain over CPU and a 10.5x energy efficiency improvement over GPU. 3D medical image registration is of great clinical importance. However, supervised learning methods require a large amount of accurately annotated corresponding control points (or morphing). The ground truth for 3D medical images is very difficult to obtain. Unsupervised learning methods ease the burden of manual annotation by exploiting unlabeled data without supervision. In this paper, we propose a new unsupervised learning method using convolutional neural networks under an end-to-end framework, Volume Tweening Network (VTN), to register 3D medical images. Three technical components ameliorate our unsupervised learning system for 3D end-to-end medical image registration: (1) We cascade the registration subnetworks; (2) We integrate affine registration into our network; and (3) We incorporate an additional invertibility loss into the training process. Experimental results demonstrate that our algorithm is 880x faster (or 3.3x faster without GPU acceleration) than traditional optimization-based methods and achieves state-of-the-art performance in medical image registration. Segmentation of 3D images is a fundamental problem in biomedical image analysis. Deep learning (DL) approaches have achieved the state-of-the-art segmentation performance. To exploit the 3D contexts using neural networks, known DL segmentation methods, including 3D convolution, 2D convolution on the planes orthogonal to 2D slices, and LSTM in multiple directions, all suffer incompatibility with the highly anisotropic dimensions in common 3D biomedical images. In this paper, we propose a new DL framework for 3D image segmentation, based on a combination of a fully convolutional network (FCN) and a recurrent neural network (RNN), which are responsible for exploiting the intra-slice and inter-slice contexts, respectively. To our best knowledge, this is the first DL framework for 3D image segmentation that explicitly leverages 3D image anisotropism. Evaluating using a dataset from the ISBI Neuronal Structure Segmentation Challenge and in-house image stacks for 3D fungus segmentation, our approach achieves promising results, comparing to the known DL-based 3D segmentation approaches. While deep convolutional neural networks (CNN) have been successfully applied for 2D image analysis, it is still challenging to apply them to 3D anisotropic volumes, especially when the within-slice resolution is much higher than the between-slice resolution and when the amount of 3D volumes is relatively small. On one hand, direct learning of CNN with 3D convolution kernels suffers from the lack of data and likely ends up with poor generalization; insufficient GPU memory limits the model size or representational power. On the other hand, applying 2D CNN with generalizable features to 2D slices ignores between-slice information. Coupling 2D network with LSTM to further handle the between-slice information is not optimal due to the difficulty in LSTM learning. To overcome the above challenges, we propose a 3D Anisotropic Hybrid Network (AH-Net) that transfers convolutional features learned from 2D images to 3D anisotropic volumes. Such a transfer inherits the desired strong generalization capability for within-slice information while naturally exploiting between-slice information for more effective modelling. The focal loss is further utilized for more effective end-to-end learning. We experiment with the proposed 3D AH-Net on two different medical image analysis tasks, namely lesion detection from a Digital Breast Tomosynthesis volume, and liver and liver tumor segmentation from a Computed Tomography volume and obtain the state-of-the-art results. Automatic and accurate whole-heart and great vessel segmentation from 3D cardiac magnetic resonance (MR) images plays an important role in the computer-assisted diagnosis and treatment of cardiovascular disease. However, this task is very challenging due to ambiguous cardiac borders and large anatomical variations among different subjects. In this paper, we propose a novel densely-connected volumetric convolutional neural network, referred as DenseVoxNet, to automatically segment the cardiac and vascular structures from 3D cardiac MR images. The DenseVoxNet adopts the 3D fully convolutional architecture for effective volume-to-volume prediction. From the learning perspective, our DenseVoxNet has three compelling advantages. First, it preserves the maximum information flow between layers by a densely-connected mechanism and hence eases the network training. Second, it avoids learning redundant feature maps by encouraging feature reuse and hence requires fewer parameters to achieve high performance, which is essential for medical applications with limited training data. Third, we add auxiliary side paths to strengthen the gradient propagation and stabilize the learning process. We demonstrate the effectiveness of DenseVoxNet by comparing it with the state-of-the-art approaches from HVSMR 2016 challenge in conjunction with MICCAI, and our network achieves the best dice coefficient. We also show that our network can achieve better performance than other 3D ConvNets but with fewer parameters. Deep learning has recently gained popularity achieving state-of-the-art performance in tasks involving text, sound, or image processing. Due to its outstanding performance, there have been efforts to apply it in more challenging scenarios, for example, 3D data processing. This article surveys methods applying deep learning on 3D data and provides a classification based on how they exploit them. From the results of the examined works, we conclude that systems employing 2D views of 3D data typically surpass voxel-based (3D) deep models, which however, can perform better with more layers and severe data augmentation. Therefore, larger-scale datasets and increased resolutions are required. This paper addresses 3D shape recognition. Recent work typically represents a 3D shape as a set of binary variables corresponding to 3D voxels of a uniform 3D grid centered on the shape, and resorts to deep convolutional neural networks(CNNs) for modeling these binary variables. Robust learning of such CNNs is currently limited by the small datasets of 3D shapes available, an order of magnitude smaller than other common datasets in computer vision. Related work typically deals with the small training datasets using a number of ad hoc, hand-tuning strategies. To address this issue, we formulate CNN learning as a beam search aimed at identifying an optimal CNN architecture, namely, the number of layers, nodes, and their connectivity in the network, as well as estimating parameters of such an optimal CNN. Each state of the beam search corresponds to a candidate CNN. Two types of actions are defined to add new convolutional filters or new convolutional layers to a parent CNN, and thus transition to children states. The utility function of each action is efficiently computed by transferring parameter values of the parent CNN to its children, thereby enabling an efficient beam search. Our experimental evaluation on the 3D ModelNet dataset demonstrates that our model pursuit using the beam search yields a CNN with superior performance on 3D shape classification than the state of the art. During the last few years, Convolutional Neural Networks are slowly but surely becoming the default method solve many computer vision related problems. This is mainly due to the continuous success that they have achieved when applied to certain tasks such as image, speech, or object recognition. Despite all the efforts, object class recognition methods based on deep learning techniques still have room for improvement. Most of the current approaches do not fully exploit 3D information, which has been proven to effectively improve the performance of other traditional object recognition methods. In this work, we propose PointNet, a new approach inspired by VoxNet and 3D ShapeNets, as an improvement over the existing methods by using density occupancy grids representations for the input data, and integrating them into a supervised Convolutional Neural Network architecture. An extensive experimentation was carried out, using ModelNet - a large-scale 3D CAD models dataset - to train and test the system, to prove that our approach is on par with state-of-the-art methods in terms of accuracy while being able to perform recognition under real-time constraints. We develop three efficient approaches for generating visual explanations from 3D convolutional neural networks (3D-CNNs) for Alzheimer's disease classification. One approach conducts sensitivity analysis on hierarchical 3D image segmentation, and the other two visualize network activations on a spatial map. Visual checks and a quantitative localization benchmark indicate that all approaches identify important brain parts for Alzheimer's disease diagnosis. Comparative analysis show that the sensitivity analysis based approach has difficulty handling loosely distributed cerebral cortex, and approaches based on visualization of activations are constrained by the resolution of the convolutional layer. The complementarity of these methods improves the understanding of 3D-CNNs in Alzheimer's disease classification from different perspectives.