In this paper, we design a drug release mechanism for dynamic time division multiple access (TDMA)-based molecular communication via diffusion (MCvD). In the proposed scheme, the communication frame is divided into several time slots over each of which a transmitter nanomachine is scheduled to convey its information by releasing the molecules into the medium. To optimize the number of released molecules and the time duration of each time slot (symbol duration), we formulate a multi-objective optimization problem whose objective functions are the bit error rate (BER) of each transmitter nanomachine. Based on the number of released molecules and symbol durations, we consider four cases, namely: "static-time static-number of molecules" (STSN), "static-time dynamic-number of molecules" (STDN), "dynamic-time static-number of molecules" (DTSN), and "dynamic-time dynamic-number of molecules" (DTDN). We consider three types of medium in which the molecules are propagated, namely: "mild diffusive environment" (MDE), "moderate diffusive environment" (MODE), and "severe diffusive environment" (SDE). For the channel model, we consider a 3-dimensional (3D) diffusive environment, such as blood, with drift in three directions. Simulation results show that the STSN approach is the least complex one with BER around @math , but, the DTDN is the most complex scenario with the BER around @math .
Researchers study the TDMA optimization in neuron-based MC, which employs neurons to communicate and built in-body sensor-actuator networks (IBSANs) @cite_23 . They use an evolutionary multi-objective optimization algorithm to design the TDMA schedule. The resource allocation in MC has already studied for two transmitter nodes in @cite_10 where the authors propose a game-theoretic framework and study Bit Error Rate (BER) of such a system. In addition, the investigation of the channel capacity for multiple-access channels, which employs the principles of natural ligand-receptor is studied in @cite_24 . Furthermore, the researchers have found a high capacity in Single-input Single-output (SISO) and Multi-input Single-output (MISO)-based MC system @cite_24 . The investigation of more than two transmitter nodes in multiple access channel in existing works has not been considered yet. In addition, TDMA in Molecular Communication via Diffusion (MCvD) system has not been studied in the existing works on MC. The optimization of symbol durations and the number of released molecules by each transmitter node is also not considered in the existing works.
@cite_24 @cite_10 @cite_23
2140013661 2119160818 2031540173
Molecular communication is a new nano-scale communication paradigm that enables nanomachines to communicate with each other by emitting molecules to their surrounding environment. Nanonetworks are also envisioned to be composed of a number of nanomachines with molecular communication capability that are deployed in an environment to share specific molecular information such as odor, flavour, light, or any chemical state. In this paper, using the principles of natural ligand-receptor binding mechanisms in biology, we first derive a capacity expression for single molecular channel in which a single Transmitter Nanomachine (TN) communicates with a single Receiver Nanomachine (RN). Then, we investigate the capacity of the molecular multiple-access channel in which multiple TNs communicate with a single RN. Numerical results reveal that high molecular communication capacities can be attainable for the single and multiple-access molecular channels. Molecular communication (MC) will enable the exchange of information among nanoscale devices. In this novel bio-inspired communication paradigm, molecules are employed to encode, transmit and receive information. In the most general case, these molecules are propagated in the medium by means of free diffusion. An information theoretical analysis of diffusion-based MC is required to better understand the potential of this novel communication mechanism. The study and the modeling of the noise sources is of utmost importance for this analysis. The objective of this paper is to provide a mathematical study of the noise at the reception of the molecular information in a diffusion-based MC system when the ligand-binding reception is employed. The reference diffusion-based MC system for this analysis is the physical end-to-end model introduced in a previous work by the same authors, where the reception process is realized through ligand-binding chemical receptors. The reception noise is modeled in this paper by following two different approaches, namely, through the ligand-receptor kinetics and through the stochastic chemical kinetics. The ligand-receptor kinetics allows to simulate the random perturbations in the chemical processes of the reception, while the stochastic chemical kinetics provides the tools to derive a closed-form solution to the modeling of the reception noise. The ligand-receptor kinetics model is expressed through a block scheme, while the stochastic chemical kinetics results in the characterization of the reception noise using stochastic differential equations. Numerical results are provided to demonstrate that the analytical formulation of the reception noise in terms of stochastic chemical kinetics is compliant with the reception noise behavior resulting from the ligand-receptor kinetics simulations. This paper proposes and evaluates Neuronal TDMA, a TDMA-based signaling protocol framework for molecular communication, which utilizes neurons as a primary component to build in-body sensor-actuator networks (IBSANs). Neuronal TDMA leverages an evolutionary multiobjective optimization algorithm (EMOA) that optimizes the signaling schedule for nanomachines in IBSANs. The proposed EMOA uses a population of solution candidates, each of which represents a particular signaling schedule, and evolves them via several operators such as selection, crossover, mutation and offspring size adjustment. The evolution process is performed to seek Pareto-optimal signaling schedules subject to given constraints. Simulation results verify that the proposed EMOA efficiently obtains quality solutions. It outperforms several conventional EMOAs. A critical issue in applications involving networks of wireless sensors is their ability to synchronize, and mitigate the fading propagation channel effects. Especially when distributed “slave” sensors (nodes) reach-back to communicate with the “master” sensor (gateway), low power cooperative schemes are well motivated. Viewing each node as an antenna element in a multi-input multi-output (MIMO) multi-antenna system, we design pilot patterns to estimate the multiple carrier frequency offsets (CFO), and the multiple channels corresponding to each node-gateway link. Our novel pilot scheme consists of non-zero pilot symbols along with zeros, which separate nodes in a time division multiple access (TDMA) fashion, and lead to low complexity schemes because CFO and channel estimators per node are decoupled. The resulting training algorithm is not only suitable for wireless sensor networks, but also for synchronization and channel estimation of single- and multi-carrier MIMO systems. We investigate the performance of our estimators analytically, and with simulations. With bandwidths on the order of a gigahertz in emerging wireless systems, high-resolution analog-to-digital convertors (ADCs) become a power consumption bottleneck. One solution is to employ low resolution one-bit ADCs. In this paper, we analyze the flat fading multiple-input multiple-output (MIMO) channel with one-bit ADCs. Channel state information is assumed to be known at both the transmitter and receiver. For the multiple-input single-output channel, we derive the exact channel capacity. For the single-input multiple-output and MIMO channel, the capacity at infinite signal-to-noise ratio (SNR) is found. We also derive upper bound at finite SNR, which is tight when the channel has full row rank. In addition, we propose an efficient method to design the input symbols to approach the capacity achieving solution. We incorporate millimeter wave channel characteristics and find the bounds on the infinite SNR capacity. The results show how the number of paths and number of receive antennas impact the capacity. Abstract Simulation-based and information theoretic models for a diffusion-based short-range molecular communication channel between a nano-transmitter and a nano-receiver are constructed to analyze information rates between channel inputs and outputs when the inputs are independent and identically distributed (i.i.d.). The total number of molecules available for information transfer is assumed to be limited. It is also assumed that there is a maximum tolerable delay bound for the overall information transfer. Information rates are computed via simulation-based methods for different time slot lengths and transmitter–receiver distances. The rates obtained from simulations are then compared to those computed using information theoretic channel models which provide upper bounds for information rates. The results indicate that a 4-input–2-output discrete channel model provides a very good approximation to the nano-communication channel, particularly when the time slot lengths are large and the distance between the transmitter and the receiver is small. It is shown through an extensive set of simulations that the information theoretic channel capacity with i.i.d. inputs can be achieved when an encoder adjusts the relative frequency of binary zeros to be higher (between 50 and 70 for the scenarios considered) than binary ones, where a ‘zero’ corresponds to not releasing and a ‘one’ corresponds to releasing a molecule from the transmitter. In a diffusion-based molecular communication network, transmitters and receivers communicate by using signalling molecules (or ligands) in a fluid medium. This paper assumes that the transmitter uses different chemical reactions to generate different emission patterns of signalling molecules to represent different transmission symbols, and the receiver consists of receptors. When the signalling molecules arrive at the receiver, they may react with the receptors to form ligand-receptor complexes. Our goal is to study the demodulation in this setup assuming that the transmitter and receiver are synchronised. We derive an optimal demodulator using the continuous history of the number of complexes at the receiver as the input to the demodulator. We do that by first deriving a communication model which includes the chemical reactions in the transmitter, diffusion in the transmission medium and the ligand-receptor process in the receiver. This model, which takes the form of a continuous-time Markov process, captures the noise in the receiver signal due to the stochastic nature of chemical reactions and diffusion. We then adopt a maximum a posteriori framework and use Bayesian filtering to derive the optimal demodulator. We use numerical examples to illustrate the properties of this optimal demodulator. A diffusion-based molecular communication system has two major components: the diffusion in the medium, and the ligand-reception. Information bits, encoded in the time variations of the concentration of molecules, are conveyed to the receiver front through the molecular diffusion in the medium. The receiver, in turn, measures the concentration of the molecules in its vicinity in order to retrieve the information. This is done via ligand-reception process. In this paper, we develop models to study the constraints imposed by the concentration sensing at the receiver side and derive the maximum rate by which a ligand-receiver can receive information. Therefore, the overall capacity of the diffusion channel with the ligand receptors can be obtained by combining the results presented in this paper with our previous work on the achievable information rate of molecular communication over the diffusion channel. Molecular communication networks can be used to realise communication between nanoscale devices. In a molecular communication network, transmitters and receivers communicate by using signalling molecules. At the receivers, the signalling molecules react, via a chain of chemical reactions, to produce output molecules. The counts of output molecules over time is the output signal of the receiver. The output signal is noisy due to the stochastic nature of diffusion and chemical reactions. This paper aims to characterise the properties of the output signal. We do this by modelling the transmission medium, transmitter and receiver. In order to simplify the analysis, we model the transmitter as a sequence which specifies the number of molecules emitted by the transmitter over time. This paper considers two receiver reaction mechanisms, reversible conversion and linear catalytic, which can be used to approximate, respectively, ligand-receptor binding and enzymatic reactions. These two mechanisms are chosen because, if we consider them on their own (i.e. without the transmitter and diffusion), the ordinary differential equations describing the mean behaviour of these two reaction mechanisms have the same form; however, if we consider the end-to-end behaviour from the transmitter signal to the mean variance of the number of output molecules, then these two receiver reaction mechanisms have very different behaviours. We show this by deriving analytical expressions for the mean, variance and frequency properties of the number of output molecules of these two receiver reaction mechanisms. In addition, for reversible conversion, we are able to derive the exact probability distribution of the number of output molecules. Our model allows us to study the impact of design parameters on the communication performance. For example, we assume that our receiver is enclosed by a membrane and we study the impact of the diffusibility of molecules across this membrane on the communication performance. With much advancement in the field of nanotechnology, bioengineering, and synthetic biology over the past decade, microscales and nanoscales devices are becoming a reality. Yet the problem of engineering a reliable communication system between tiny devices is still an open problem. At the same time, despite the prevalence of radio communication, there are still areas where traditional electromagnetic waves find it difficult or expensive to reach. Points of interest in industry, cities, and medical applications often lie in embedded and entrenched areas, accessible only by ventricles at scales too small for conventional radio waves and microwaves, or they are located in such a way that directional high frequency systems are ineffective. Inspired by nature, one solution to these problems is molecular communication (MC), where chemical signals are used to transfer information. Although biologists have studied MC for decades, it has only been researched for roughly 10 year from a communication engineering lens. Significant number of papers have been published to date, but owing to the need for interdisciplinary work, much of the results are preliminary. In this survey, the recent advancements in the field of MC engineering are highlighted. First, the biological, chemical, and physical processes used by an MC system are discussed. This includes different components of the MC transmitter and receiver, as well as the propagation and transport mechanisms. Then, a comprehensive survey of some of the recent works on MC through a communication engineering lens is provided. The survey ends with a technology readiness analysis of MC and future research directions. Multiple-input-multiple-output (MIMO) communication systems can provide large capacity gains over traditional single-input-single-output (SISO) systems and are expected to be a core technology of next generation wireless systems. Often, these capacity gains are achievable only with some form of adaptive transmission. In this paper, we study the capacity loss (defined as the rate loss in bits s Hz) of the MIMO wireless system when the covariance matrix of the transmitted signal vector is designed using a low rate feedback channel. For the MIMO channel, we find a bound on the ergodic capacity loss when random codebooks, generated from the uniform distribution on the complex unit sphere, are used to convey the second order statistics of the transmitted signal from the receiver to the transmitter. In this case, we find a closed-form expression for the ergodic capacity loss as a function of the number of bits fed back at each channel realization. These results show that the capacity loss decreases at least as O(2 sup -B (2MMt-2) ) where B is the number of feedback bits, M sub t is the number of transmit antennas, and M=min M sub r ,M sub t where M sub r is the number of receive antennas. In the high SNR regime, we present a new bound on the capacity loss that is tighter than the previously derived bound and show that the capacity loss decreases exponentially as a function of the number of feedback bits. This paper considers the transmitter design for wireless information and energy transfer (WIET) in a multiple-input single-output (MISO) interference channel (IFC). The design problem is to maximize the system throughput subject to individual energy harvesting constraints and power constraints. It is observed that the ideal scheme, where the receivers simultaneously perform information detection (ID) and energy harvesting (EH) from the received signal, may not always achieve the best tradeoff between information transfer and energy harvesting, but simple practical schemes based on time splitting may perform better. We therefore propose two practical time splitting schemes, namely the time-division mode switching (TDMS) and time-division multiple access (TDMA), in addition to the existing power splitting (PS) scheme. In the two-user scenario, we show that beamforming is optimal to all the schemes. Moreover, the design problems associated with the TDMS and TDMA schemes admit semi-analytical solutions. In the general K-user scenario, a successive convex approximation method is proposed to handle the WIET problems associated with the ideal scheme, the PS scheme and the TDMA scheme, which are known NP-hard in general. Simulation results show that none of the schemes under consideration can always dominate another in terms of the sum rate performance. Specifically, it is observed that stronger cross-link channel power improves the achievable sum rate of time splitting schemes but degrades the sum rate performance of the ideal scheme and PS scheme. As a result, time splitting schemes can outperform the ideal scheme and the PS scheme in interference dominated scenarios. In this paper, we propose a novel multi-channel wireless network with infrastructure support, called an MC-IS network. To the best of our knowledge, we are the first to study the capacity and the delay of such an MC-IS network. In particular, we derive the upper bounds and the lower bounds on the network capacity of such MC-IS networks contributed by ad hoc communications, where the orders of the upper bounds are the same as the orders of the lower bounds, implying that the bounds are tight. We also found that the capacity of MC-IS networks contributed by ad hoc communications is mainly limited by connectivity requirement, interference requirement, destination-bottleneck requirement and interface-bottleneck requirement. In addition, we also derive the average delay of MC-IS networks contributed by ad hoc communications, which is bounded by the maximum number of hops. Many transmission scheduling algorithms have been proposed to maximize spatial reuse and minimize the time division multiple access (TDMA) frame length in multihop packet radio networks. Almost all existing algorithms assume exact network topology information and require recomputations when the network topology changes. In addition, existing work focuses on single channel TDMA systems. In this paper, we propose a multichannel topology-transparent algorithm based on latin squares. The proposed algorithm has the flexibility to allow the growth of the network, i.e., the network can add more mobile nodes without recomputation of transmission schedules for existing nodes. At the same time, a minimum throughput is guaranteed. We analyze the efficiency of this algorithm and examine the topology-transparent characteristics and the sensitivity on design parameters by analytical and simulation techniques. We consider a channel model based on the diffusion of particles in the medium which is motivated by the natural communication mechanisms between biological cells based on exchange of molecules. In this model, the transmitter secretes particles into the medium via a particle dissemination rate. The concentration of particles at any point in the medium is a function of its distance from the transmitter and the particle dissemination rate. The reception process is a doubly stochastic Poisson process whose rate is a function of the concentration of the particles in the vicinity of the receiver. We derive a closed-form for the mutual information between the input and output processes in this communication scenario and establish useful properties about the mutual information. We also provide a signaling strategy using which we derive a lower bound on the capacity of the diffusion channel with Poisson reception process under average and peak power constraints. Furthermore, it is shown that the capacity of discretized diffusion channel can be a negligible factor of the capacity of continuous time diffusion channel. Finally, the application of the considered model to the molecular communication systems is discussed. In this paper, we consider molecular communication, with information conveyed in the time of release of molecules. These molecules propagate to the transmitter through a fluid medium, propelled by a positive drift velocity and Brownian motion. The main contribution of this paper is the development of a theoretical foundation for such a communication system; specifically, the additive inverse Gaussian noise (AIGN) channel model. In such a channel, the information is corrupted by noise that follows an IG distribution. We show that such a channel model is appropriate for molecular communication in fluid media. Taking advantage of the available literature on the IG distribution, upper and lower bounds on channel capacity are developed, and a maximum likelihood receiver is derived. Results are presented which suggest that this channel does not have a single quality measure analogous to signal-to-noise ratio in the additive white Gaussian noise channel. It is also shown that the use of multiple molecules leads to reduced error rate in a manner akin to diversity order in wireless communications. Finally, some open problems are discussed that arise from the IG channel model. We consider the problem of power allocation over one or more time-varying channels with unknown distributions in energy harvesting communications. In the single-channel case, the transmitter chooses the transmit power based on the amount of stored energy in its battery with the goal of maximizing the average rate over time. We model this problem as a Markov decision process (MDP) with transmitter as the agent, battery status as the state, transmits power as the action and rate as the reward. The average reward maximization problem can be modeled by a linear program (LP) that uses the transition probabilities for the state-action pairs and their reward values to select a power allocation policy. This problem is challenging because the uncertainty in channels implies that the mean rewards associated with the state-action pairs are unknown. We therefore propose two online learning algorithms: linear program of sample means (LPSM) and Epoch-LPSM that learn these rewards and adapt their policies over time. For both algorithms, we prove that their regret is upper-bounded by a constant. To our knowledge this is the first result showing constant regret learning algorithms for MDPs with unknown mean rewards. We also prove an even stronger result about LPSM: that its policy matches the optimal policy exactly in finite expected time. Epoch-LPSM incurs a higher regret compared with the LPSM, while reducing the computational requirements substantially. We further consider a multi-channel scenario, where the agent also chooses a channel in each slot, and present our multi-channel LPSM (MC-LPSM) algorithm that explores different channels and uses that information to solve the LP during exploitation. MC-LPSM incurs a regret that scales logarithmically in time and linearly in the number of channels. Through a matching lower bound on the regret of any algorithm, we also prove the asymptotic order optimality of MC-LPSM. Molecular Communication (MC) is a bio-inspired communication technique that uses molecules as a method of information transfer among nanoscale devices. MC receiver is an essential component having profound impact on the communication system performance. However, the interaction of the receiver with information bearing molecules has been usually oversimplified in modeling the reception process and developing signal detection techniques. In this paper, we focus on the signal detection problem of MC receivers employing receptor molecules to infer the transmitted messages encoded into the concentration of molecules, i.e., ligands. Exploiting the observable characteristics of ligand-receptor binding reaction, we first introduce a Maximum Likelihood (ML) detection method based on instantaneous receptor occupation ratio, as aligned with the current MC literature. Then, we propose a novel ML detection technique, which exploits the amount of time the receptors stay unbound in an observation time window. A comprehensive analysis is carried out to compare the performance of the detectors in terms of bit error probability. In evaluating the detection performance, emphasis is given to the receptor saturation problem resulting from the accumulation of messenger molecules at the receiver as a consequence of intersymbol interference. The results reveal that detection based on receptor unbound time is quite reliable even in saturation, whereas the reliability of detection based on receptor occupation ratio substantially decreases as the receiver gets saturated. Finally, we also discuss the potential methods of implementing the detectors. Currently, communication between nanomachines is an important topic for the development of novel devices. To implement a nanocommunication system, diffusion-based molecular communication is considered as a promising bio-inspired approach. Various technical issues about molecular communications, including channel capacity, noise and interference, and modulation and coding, have been studied in the literature, while the resource allocation problem among multiple nanomachines has not been well investigated, which is a very important issue since all the nanomachines share the same propagation medium. Considering the limited computation capability of nanomachines and the expensive information exchange cost among them, in this paper, we propose a game-theoretic framework for distributed resource allocation in nanoscale molecular communication systems. We first analyze the inter-symbol and inter-user interference, as well as bit error rate performance, in the molecular communication system. Based on the interference analysis, we formulate the resource allocation problem as a non-cooperative molecule emission control game, where the Nash equilibrium is found and proved to be unique. In order to improve the system efficiency while guaranteeing fairness, we further model the resource allocation problem using a cooperative game based on the Nash bargaining solution, which is proved to be proportionally fair. Simulation results show that the Nash bargaining solution can effectively ensure fairness among multiple nanomachines while achieving comparable social welfare performance with the centralized scheme. Optimization of a point-to-point (p2p) multiple-input single-output (MISO) communication system is considered when both the transmitter (TX) and the receiver (RX) have energy harvesting (EH) capabilities. The RX is interested in feeding back the channel state information (CSI) to the TX to help improve the transmission rate. The objective is to maximize the throughput by a deadline, subject to the EH constraints at the TX and the RX. The throughput metric considered is an upper bound on the ergodic rate of the MISO channel with beamforming and limited feedback. Feedback bit allocation and transmission policies that maximize the upper bound on the ergodic rate are obtained. Tools from majorization theory are used to simplify the formulated optimization problems. Optimal policies obtained for the modified problem outperform the naive scheme in which no intelligent management of energy is performed.