Abstract Clinical named entity recognition aims to identify and classify clinical terms such as diseases, symptoms, treatments, exams, and body parts in electronic health records, which is a fundamental and crucial task for clinical and translational research. In recent years, deep neural networks have achieved significant success in named entity recognition and many other natural language processing tasks. Most of these algorithms are trained end to end, and can automatically learn features from large scale labeled datasets. However, these data-driven methods typically lack the capability of processing rare or unseen entities. Previous statistical methods and feature engineering practice have demonstrated that human knowledge can provide valuable information for handling rare and unseen cases. In this paper, we propose a new model which combines data-driven deep learning approaches and knowledge-driven dictionary approaches. Specifically, we incorporate dictionaries into deep neural networks. In addition, two different architectures that extend the bi-directional long short-term memory neural network and five different feature representation schemes are also proposed to handle the task. Computational results on the CCKS-2017 Task 2 benchmark dataset show that the proposed method achieves the highly competitive performance compared with the state-of-the-art deep learning methods.
Recently, deep learning approaches @cite_34 , especially the methods based on Bidirectional Recurrent Neural Network (RNN) using CRF as the output interface (Bi-RNN-CRF) @cite_38 , achieve state-of-the-art performance in CNER tasks and outperform the traditional statistical models @cite_29 @cite_2 @cite_31 . RNNs with gated recurrent cells, such as Long-Short Term Memory (LSTM) @cite_10 and Gated Recurrent Units (GRU) @cite_26 , are capable of capturing long dependencies and retrieving rich global information. The sequential CRF on top of the recurrent layers ensures that the optimal sequence of tags over the entire sentence is obtained.
@cite_38 @cite_26 @cite_29 @cite_2 @cite_31 @cite_34 @cite_10
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Abstract Biomedical named entity recognition (BNER), which extracts important named entities such as genes and proteins, is a challenging task in automated systems that mine knowledge in biomedical texts. The previous state-of-the-art systems required large amounts of task-specific knowledge in the form of feature engineering, lexicons and data pre-processing to achieve high performance. In this paper, we introduce a novel neural network architecture that benefits from both word- and character-level representations automatically, by using a combination of bidirectional long short-term memory (LSTM) and conditional random field (CRF) eliminating the need for most feature engineering tasks. We evaluate our system on two datasets: JNLPBA corpus and the BioCreAtIvE II Gene Mention (GM) corpus. We obtained state-of-the-art performance by outperforming the previous systems. To the best of our knowledge, we are the first to investigate the combination of deep neural networks, CRF, word embeddings and character-level representation in recognizing biomedical named entities. Text mining has become an important tool for biomedical research. The most fundamental text-mining task is the recognition of biomedical named entities (NER), such as genes, chemicals and diseases. Current NER methods rely on pre-defined features which try to capture the specific surface properties of entity types, properties of the typical local context, background knowledge, and linguistic information. State-of-the-art tools are entity-specific, as dictionaries and empirically optimal feature sets differ between entity types, which makes their development costly. Furthermore, features are often optimized for a specific gold standard corpus, which makes extrapolation of quality measures difficult.We show that a completely generic method based on deep learning and statistical word embeddings [called long short-term memory network-conditional random field (LSTM-CRF)] outperforms state-of-the-art entity-specific NER tools, and often by a large margin. To this end, we compared the performance of LSTM-CRF on 33 data sets covering five different entity classes with that of best-of-class NER tools and an entity-agnostic CRF implementation. On average, F1-score of LSTM-CRF is 5 above that of the baselines, mostly due to a sharp increase in recall.The source code for LSTM-CRF is available at https: github.com glample tagger and the links to the corpora are available at https: corposaurus.github.io corpora .habibima@informatik.hu-berlin.de. Drug-Named Entity Recognition (DNER) for biomedical literature is a fundamental facilitator of Information Extraction. For this reason, the DDIExtraction2011 (DDI2011) and DDIExtraction2013 (DDI2013) challenge introduced one task aiming at recognition of drug names. State-of-the-art DNER approaches heavily rely on hand-engineered features and domain-specific knowledge which are difficult to collect and define. Therefore, we offer an automatic exploring words and characters level features approach: a recurrent neural network using bidirectional long short-term memory (LSTM) with Conditional Random Fields decoding (LSTM-CRF). Two kinds of word representations are used in this work: word embedding, which is trained from a large amount of text, and character-based representation, which can capture orthographic feature of words. Experimental results on the DDI2011 and DDI2013 dataset show the effect of the proposed LSTM-CRF method. Our method outperforms the best system in the DDI2013 challenge. Rapid growth in electronic health records (EHRs) use has led to an unprecedented expansion of available clinical data in electronic formats. However, much of the important healthcare information is locked in the narrative documents. Therefore Natural Language Processing (NLP) technologies, e.g., Named Entity Recognition that identifies boundaries and types of entities, have been extensively studied to unlock important clinical information in free text. In this study, we investigated a novel deep learning method to recognize clinical entities in Chinese clinical documents using the minimal feature engineering approach. We developed a deep neural network (DNN) to generate word embeddings from a large unlabeled corpus through unsupervised learning and another DNN for the NER task. The experiment results showed that the DNN with word embeddings trained from the large unlabeled corpus outperformed the state-of-the-art CRF’s model in the minimal feature engineering setting, achieving the highest F1-score of 0.9280. Further analysis showed that word embeddings derived through unsupervised learning from large unlabeled corpus remarkably improved the DNN with randomized embedding, denoting the usefulness of unsupervised feature learning. Learning to store information over extended time intervals by recurrent backpropagation takes a very long time, mostly because of insufficient, decaying error backflow. We briefly review Hochreiter's (1991) analysis of this problem, then address it by introducing a novel, efficient, gradient based method called long short-term memory (LSTM). Truncating the gradient where this does not do harm, LSTM can learn to bridge minimal time lags in excess of 1000 discrete-time steps by enforcing constant error flow through constant error carousels within special units. Multiplicative gate units learn to open and close access to the constant error flow. LSTM is local in space and time; its computational complexity per time step and weight is O. 1. Our experiments with artificial data involve local, distributed, real-valued, and noisy pattern representations. In comparisons with real-time recurrent learning, back propagation through time, recurrent cascade correlation, Elman nets, and neural sequence chunking, LSTM leads to many more successful runs, and learns much faster. LSTM also solves complex, artificial long-time-lag tasks that have never been solved by previous recurrent network algorithms.