The personalized health care service utilizes the relational patient data and big data analytics to tailor the medication recommendations. However, most of the health care data are in unstructured form and it consumes a lot of time and effort to pull them into relational form. This study proposes a novel data lake architecture to reduce the data ingestion time and improve the precision of healthcare analytics. It also removes the data silos and enhances the analytics by allowing the connectivity to the third-party data providers (such as clinical lab results, chemist, insurance company,etc.). The data lake architecture uses the Hadoop Distributed File System (HDFS) to provide the storage for both structured and unstructured data. This study uses K-means clustering algorithm to find the patient clusters with similar health conditions. Subsequently, it employs a support vector machine to find the most successful healthcare recommendations for the each cluster. Our experiment results demonstrate the ability of data lake to reduce the time for ingesting data from various data vendors regardless of its format. Moreover, it is evident that the data lake poses the potential to generate clusters of patients more precisely than the existing approaches. It is obvious that the data lake provides a unified storage location for the data in its native format. It can also improve the personalized healthcare medication recommendations by removing the data silos.
The proactive, patient-centric and tailored healthcare medication recommendation to the individual based on the analysis of the corresponding person’s EHR, genomic profile, laboratory data and other related supporting data @cite_33 .
@cite_33
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With the advent of electronic health records, more data are continuously collected for individual patients, and more data are available for review from past patients. Despite this, it has not yet been possible to successfully use this data to systematically build clinical decision support systems that can produce personalized clinical recommendations to assist clinicians in providing individualized healthcare. In this paper, we present a novel approach, discovery engine (DE), that discovers which patient characteristics are most relevant for predicting the correct diagnosis and or recommending the best treatment regimen for each patient. We demonstrate the performance of DE in two clinical settings: diagnosis of breast cancer as well as a personalized recommendation for a specific chemotherapy regimen for breast cancer patients. For each distinct clinical recommendation, different patient features are relevant; DE can discover these different relevant features and use them to recommend personalized clinical decisions. The DE approach achieves a 16.6 improvement over existing state-of-the-art recommendation algorithms regarding kappa coefficients for recommending the personalized chemotherapy regimens. For diagnostic predictions, the DE approach achieves a 2.18 and 4.20 improvement over existing state-of-the-art prediction algorithms regarding prediction error rate and false positive rate, respectively. We also demonstrate that the performance of our approach is robust against missing information and that the relevant features discovered by DE are confirmed by clinical references.