Age-Related Macular Degeneration (AMD) is an asymptomatic retinal disease which may result in loss of vision. There is limited access to high-quality relevant retinal images and poor understanding of the features defining sub-classes of this disease. Motivated by recent advances in machine learning we specifically explore the potential of generative modeling, using Generative Adversarial Networks (GANs) and style transferring, to facilitate clinical diagnosis and disease understanding by feature extraction. We design an analytic pipeline which first generates synthetic retinal images from clinical images; a subsequent verification step is applied. In the synthesizing step we merge GANs (DCGANs and WGANs architectures) and style transferring for the image generation, whereas the verified step controls the accuracy of the generated images. We find that the generated images contain sufficient pathological details to facilitate ophthalmologists' task of disease classification and in discovery of disease relevant features. In particular, our system predicts the drusen and geographic atrophy sub-classes of AMD. Furthermore, the performance using CFP images for GANs outperforms the classification based on using only the original clinical dataset. Our results are evaluated using existing classifier of retinal diseases and class activated maps, supporting the predictive power of the synthetic images and their utility for feature extraction. Our code examples are available online.
Yet, a major issue has been the stability and convergence of training a GAN. Recent work @cite_19 demonstrated improved stability when using a Kantorovich-Rubinstein metric, which we have adopted in our training of the GAN for retinal images. Rapid advances have demonstrated that GANs generate realistic images, with a rich number of features. For example, GANs have been successfully applied for face generation @cite_5 , indoor scene reconstruction @cite_1 and person re-identification @cite_11 . Here we benefit from recent progress with GANs to generate new synthetic retinal disease images using both Deep Convolutional Generative Adversarial Networks (DCGANs) @cite_18 and Wasserstein GANs (WGANs) @cite_19 . These architectures utilize a convolutional decoder, and DCGAN enables the employment of large GANs using Convolutional Neural Networks (CNNs), resulting in stable training across various datasets. Finally, our use of WGANs improves the stability of learning,thereby avoiding known challenges such as model collapse @cite_19 .
@cite_18 @cite_1 @cite_19 @cite_5 @cite_11
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In recent years, supervised learning with convolutional networks (CNNs) has seen huge adoption in computer vision applications. Comparatively, unsupervised learning with CNNs has received less attention. In this work we hope to help bridge the gap between the success of CNNs for supervised learning and unsupervised learning. We introduce a class of CNNs called deep convolutional generative adversarial networks (DCGANs), that have certain architectural constraints, and demonstrate that they are a strong candidate for unsupervised learning. Training on various image datasets, we show convincing evidence that our deep convolutional adversarial pair learns a hierarchy of representations from object parts to scenes in both the generator and discriminator. Additionally, we use the learned features for novel tasks - demonstrating their applicability as general image representations. Generation of 3D data by deep neural network has been attracting increasing attention in the research community. The majority of extant works resort to regular representations such as volumetric grids or collection of images, however, these representations obscure the natural invariance of 3D shapes under geometric transformations, and also suffer from a number of other issues. In this paper we address the problem of 3D reconstruction from a single image, generating a straight-forward form of output &#x2013; point cloud coordinates. Along with this problem arises a unique and interesting issue, that the groundtruth shape for an input image may be ambiguous. Driven by this unorthordox output form and the inherent ambiguity in groundtruth, we design architecture, loss function and learning paradigm that are novel and effective. Our final solution is a conditional shape sampler, capable of predicting multiple plausible 3D point clouds from an input image. In experiments not only can our system outperform state-of-the-art methods on single image based 3D reconstruction benchmarks, but it also shows strong performance for 3D shape completion and promising ability in making multiple plausible predictions. Recent advances in Generative Adversarial Networks (GANs) have shown impressive results for task of facial expression synthesis. The most successful architecture is StarGAN, that conditions GANs’ generation process with images of a specific domain, namely a set of images of persons sharing the same expression. While effective, this approach can only generate a discrete number of expressions, determined by the content of the dataset. To address this limitation, in this paper, we introduce a novel GAN conditioning scheme based on Action Units (AU) annotations, which describes in a continuous manifold the anatomical facial movements defining a human expression. Our approach allows controlling the magnitude of activation of each AU and combine several of them. Additionally, we propose a fully unsupervised strategy to train the model, that only requires images annotated with their activated AUs, and exploit attention mechanisms that make our network robust to changing backgrounds and lighting conditions. Extensive evaluation show that our approach goes beyond competing conditional generators both in the capability to synthesize a much wider range of expressions ruled by anatomically feasible muscle movements, as in the capacity of dealing with images in the wild. Person Re-identification (re-id) faces two major challenges: the lack of cross-view paired training data and learning discriminative identity-sensitive and view-invariant features in the presence of large pose variations. In this work, we address both problems by proposing a novel deep person image generation model for synthesizing realistic person images conditional on pose. The model is based on a generative adversarial network (GAN) and used specifically for pose normalization in re-id, thus termed pose-normalization GAN (PN-GAN). With the synthesized images, we can learn a new type of deep re-id feature free of the influence of pose variations. We show that this feature is strong on its own and highly complementary to features learned with the original images. Importantly, we now have a model that generalizes to any new re-id dataset without the need for collecting any training data for model fine-tuning, thus making a deep re-id model truly scalable. Extensive experiments on five benchmarks show that our model outperforms the state-of-the-art models, often significantly. In particular, the features learned on Market-1501 can achieve a Rank-1 accuracy of 68.67 on VIPeR without any model fine-tuning, beating almost all existing models fine-tuned on the dataset.