Parameter inference for stochastic differential equations is challenging due to the presence of a latent diffusion process. Working with an Euler-Maruyama discretisation for the diffusion, we use variational inference to jointly learn the parameters and the diffusion paths. We use a standard mean-field variational approximation of the parameter posterior, and introduce a recurrent neural network to approximate the posterior for the diffusion paths conditional on the parameters. This neural network learns how to provide Gaussian state transitions which bridge between observations in a very similar way to the conditioned diffusion process. The resulting black-box inference method can be applied to any SDE system with light tuning requirements. We illustrate the method on a Lotka-Volterra system and an epidemic model, producing accurate parameter estimates in a few hours.
Another Monte Carlo approach is to perform approximate inference based on low dimensional summary statistics of the observations @cite_13 . This results in a loss of information, which our approach avoids.
@cite_13
2127281696
Models defined by stochastic differential equations (SDEs) allow for the representation of random variability in dynamical systems. The relevance of this class of models is growing in many applied research areas and is already a standard tool to model, for example, financial, neuronal, and population growth dynamics. However, inference for multidimensional SDE models is still very challenging, both computationally and theoretically. Approximate Bayesian computation (ABC) allows to perform Bayesian inference for models which are sufficiently complex that the likelihood function is either analytically unavailable or computationally prohibitive to evaluate. A computationally efficient ABC-MCMC algorithm is proposed, halving the running time in our simulations. Focus here is on the case where the SDE describes latent dynamics in state-space models; however, the methodology is not limited to the state-space framework. We consider simulation studies for a pharmacokinetics pharmacodynamics model and for stochast...