Segmenting the retinal vasculature entails a trade-off between how much of the overall vascular structure we identify vs. how precisely we segment individual vessels. In particular, state-of-the-art methods tend to under-segment faint vessels, as well as pixels that lie on the edges of thicker vessels. Thus, they underestimate the width of individual vessels, as well as the ratio of large to small vessels. More generally, many crucial bio-markers---including the artery-vein (AV) ratio, branching angles, number of bifurcation, fractal dimension, tortuosity, vascular length-to-diameter ratio and wall-to-lumen length---require precise measurements of individual vessels. To address this limitation, we propose a novel, stochastic training scheme for deep neural networks that better classifies the faint, ambiguous regions of the image. Our approach relies on two key innovations. First, we train our deep networks with dynamic weights that fluctuate during each training iteration. This stochastic approach forces the network to learn a mapping that robustly balances precision and recall. Second, we decouple the segmentation process into two steps. In the first half of our pipeline, we estimate the likelihood of every pixel and then use these likelihoods to segment pixels that are clearly vessel or background. In the latter part of our pipeline, we use a second network to classify the ambiguous regions in the image. Our proposed method obtained state-of-the-art results on five retinal datasets---DRIVE, STARE, CHASE-DB, AV-WIDE, and VEVIO---by learning a robust balance between false positive and false negative rates. In addition, we are the first to report segmentation results on the AV-WIDE dataset, and we have made the ground-truth annotations for this dataset publicly available.
Vessel segmentation has a long history, although the advent of deep neural networks has yielded significant improvements in recent years. Earlier techniques relied primarily on handcrafted features, including matched filters @cite_32 , quadrature filters @cite_8 , and Gabor filters @cite_17 @cite_5 . The latter approach, in particular, uses a predefined kernel bank to incorporate all vessel widths and orientations. However, handcrafted features are limited by our ability to analytically model the segmentation process. Other classic techniques, as surveyed further in @cite_7 , include piece-wise thresholding @cite_4 , region growing @cite_20 , and concavity measurements @cite_16 . In addition to handcrafted features, some prior approaches used graph-theoretic techniques to trace the vascular structure, including shortest-path tracking @cite_13 and the fast marching algorithm @cite_25 .
@cite_4 @cite_7 @cite_8 @cite_32 @cite_5 @cite_16 @cite_13 @cite_25 @cite_20 @cite_17
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Describes an automated method to locate and outline blood vessels in images of the ocular fundus. Such a tool should prove useful to eye care specialists for purposes of patient screening, treatment evaluation, and clinical study. The authors' method differs from previously known methods in that it uses local and global vessel features cooperatively to segment the vessel network. The authors evaluate their method using hand-labeled ground truth segmentations of 20 images. A plot of the operating characteristic shows that the authors' method reduces false positives by as much as 15 times over basic thresholding of a matched filter response (MFR), at up to a 75 true positive rate. For a baseline, they also compared the ground truth against a second hand-labeling, yielding a 90 true positive and a 4 false positive detection rate, on average. These numbers suggest there is still room for a 15 true positive rate improvement, with the same false positive rate, over the authors' method. They are making all their images and hand labelings publicly available for interested researchers to use in evaluating related methods. The Image segmentation is referred to as one of the most important processes of image processing. Image segmentation is the technique of dividing or partitioning an image into parts, called segments. It is mostly useful for applications like image compression or object recognition, because for these types of applications, it is inefficient to process the whole image. So, image segmentation is used to segment the parts from image for further processing. There exist several image segmentation techniques, which partition the image into several parts based on certain image features like pixel intensity value, color, texture, etc. These all techniques are categorized based on the segmentation method used. In this paper the various image segmentation techniques are reviewed, discussed and finally a comparison of their advantages and disadvantages is listed. The segmentation of blood vessels is a common problem in medical imaging and various applications are found in diagnostics, surgical planning, training and more. Among many different techniques, the use of multiple scales and line detectors is a popular approach. However, the typical line filters used are sensitive to intensity variations and do not target the detection of vessel walls explicitly. In this article, we combine both line and edge detection using quadrature filters across multiple scales. The filter result gives well defined vessels as linear structures, while distinct edges facilitate a robust segmentation. We apply the filter output to energy optimization techniques for segmentation and show promising results in 2D and 3D to illustrate the behavior of our method. The conference version of this article received the best paper award in the bioinformatics and biomedical applications track at ICPR 2008. Blood vessels usually have poor local contrast, and the application of existing edge detection algorithms yield results which are not satisfactory. An operator for feature extraction based on the optical and spatial properties of objects to be recognized is introduced. The gray-level profile of the cross section of a blood vessel is approximated by a Gaussian-shaped curve. The concept of matched filter detection of signals is used to detect piecewise linear segments of blood vessels in these images. Twelve different templates that are used to search for vessel segments along all possible directions are constructed. Various issues related to the implementation of these matched filters are discussed. The results are compared to those obtained with other methods. > Detecting blood vessels in retinal images with the presence of bright and dark lesions is a challenging unsolved problem. In this paper, a novel multiconcavity modeling approach is proposed to handle both healthy and unhealthy retinas simultaneously. The differentiable concavity measure is proposed to handle bright lesions in a perceptive space. The line-shape concavity measure is proposed to remove dark lesions which have an intensity structure different from the line-shaped vessels in a retina. The locally normalized concavity measure is designed to deal with unevenly distributed noise due to the spherical intensity variation in a retinal image. These concavity measures are combined together according to their statistical distributions to detect vessels in general retinal images. Very encouraging experimental results demonstrate that the proposed method consistently yields the best performance over existing state-of-the-art methods on the abnormal retinas and its accuracy outperforms the human observer, which has not been achieved by any of the state-of-the-art benchmark methods. Most importantly, unlike existing methods, the proposed method shows very attractive performances not only on healthy retinas but also on a mixture of healthy and pathological retinas. We present a methodology for extracting the vascular network in the human retina using Dijkstra’s shortest-path algorithm. Our method preserves vessel thickness, requires no manual intervention, and follows vessel branching naturally and efficiently. To test our method, we constructed a retinal video indirect ophthalmoscopy (VIO) image database from pediatric patients and compared the segmentations achieved by our method and state-of-the-art approaches to a human-drawn gold standard. Our experimental results show that our algorithm outperforms prior state-of-the-art methods, for both single VIO frames and automatically generated, large field-of-view enhanced mosaics. We have made the corresponding dataset and source code freely available online. We present a new interactive method for tubular structure extraction. The main application and motivation for this work is vessel tracking in 2D and 3D images. The basic tools are minimal paths solved using the fast marching algorithm. This allows interactive tools for the physician by clicking on a small number of points in order to obtain a minimal path between two points or a set of paths in the case of a tree structure. Our method is based on a variant of the minimal path method that models the vessel as a centerline and surface. This is done by adding one dimension for the local radius around the centerline. The crucial step of our method is the definition of the local metrics to minimize. We have chosen to exploit the tubular structure of the vessels one wants to extract to built an anisotropic metric. The designed metric is well oriented along the direction of the vessel, admits higher velocity on the centerline, and provides a good estimate of the vessel radius. Based on the optimally oriented flux this measure is required to be robust against the disturbance introduced by noise or adjacent structures with intensity similar to the target vessel. We obtain promising results on noisy synthetic and real 2D and 3D images and we present a clinical validation. We present a method for retinal blood vessel segmentation based upon the scale-space analysis of the first and second derivative of the intensity image which gives information about its topology and overcomes the problem of variations in contrast inherent in these images. We use the local maxima over scales of the magnitude of the gradient and the maximum principal curvature as the two features used in a region growing procedure. In the first stage, the growth is constrained to regions of low gradient magnitude. In the final stage this constraint is relaxed to allow borders between regions to be defined. The algorithm is tested in both red-free and fluorescein retinal images. Retinal blood vessel segmentation is a widely used process in diagnosis of various diseases such as diabetic retinopathy, glaucoma and arteriosclerosis. Therefore, an automated tool developed for vessel segmentation could be employed in diagnosis of those illnesses to help ophthalmologists. In this paper, we suggest a method to segment retinal blood vessels automatically. In the method, we apply top-hat transform after Gabor filter to enhance blood vessels. Later on, the output of the transformation is converted to binary image with p-tile thresholding. In order to test the developed system 20 images obtained from STARE database are used for performance evaluation. The results shows 86.31 of true positive rate (sensivity) and 92.90 of accuracy, which is promising.