Age-Related Macular Degeneration (AMD) is an asymptomatic retinal disease which may result in loss of vision. There is limited access to high-quality relevant retinal images and poor understanding of the features defining sub-classes of this disease. Motivated by recent advances in machine learning we specifically explore the potential of generative modeling, using Generative Adversarial Networks (GANs) and style transferring, to facilitate clinical diagnosis and disease understanding by feature extraction. We design an analytic pipeline which first generates synthetic retinal images from clinical images; a subsequent verification step is applied. In the synthesizing step we merge GANs (DCGANs and WGANs architectures) and style transferring for the image generation, whereas the verified step controls the accuracy of the generated images. We find that the generated images contain sufficient pathological details to facilitate ophthalmologists' task of disease classification and in discovery of disease relevant features. In particular, our system predicts the drusen and geographic atrophy sub-classes of AMD. Furthermore, the performance using CFP images for GANs outperforms the classification based on using only the original clinical dataset. Our results are evaluated using existing classifier of retinal diseases and class activated maps, supporting the predictive power of the synthetic images and their utility for feature extraction. Our code examples are available online.
Recently, researchers have used convolutional neural networks to generate images @cite_17 with different given style. The method makes use of a pre-trained network to optimize the image and its features. However, this method operates as a global optimization; therefore, generated image exhibit distortions and detailed parts cannot be presented on the transferred images. Meeting this challenge, recent work @cite_21 accomplished realistic image generation and style transferring. On the other hand, in @cite_18 , authors combined a convolutional neural network and GANs to generate new images, thus mitigating the impact of a limited number of features of pathological relevance in original images. While their work clearly improved the state-of-the-art methods, the technique may generate poor image samples or fails to converge. To ensure convergence and quality of generated images, we deploy a closed form solution for style transferring @cite_9 .
@cite_9 @cite_18 @cite_21 @cite_17
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Photorealistic image style transfer algorithms aim at stylizing a content photo using the style of a reference photo with the constraint that the stylized photo should remains photorealistic. While several methods exist for this task, they tend to generate spatially inconsistent stylizations with noticeable artifacts. In addition, these methods are computationally expensive, requiring several minutes to stylize a VGA photo. In this paper, we present a novel algorithm to address the limitations. The proposed algorithm consists of a stylization step and a smoothing step. While the stylization step transfers the style of the reference photo to the content photo, the smoothing step encourages spatially consistent stylizations. Unlike existing algorithms that require iterative optimization, both steps in our algorithm have closed-form solutions. Experimental results show that the stylized photos generated by our algorithm are twice more preferred by human subjects in average. Moreover, our method runs 60 times faster than the state-of-the-art approach. Code and additional results are available at this https URL In recent years, supervised learning with convolutional networks (CNNs) has seen huge adoption in computer vision applications. Comparatively, unsupervised learning with CNNs has received less attention. In this work we hope to help bridge the gap between the success of CNNs for supervised learning and unsupervised learning. We introduce a class of CNNs called deep convolutional generative adversarial networks (DCGANs), that have certain architectural constraints, and demonstrate that they are a strong candidate for unsupervised learning. Training on various image datasets, we show convincing evidence that our deep convolutional adversarial pair learns a hierarchy of representations from object parts to scenes in both the generator and discriminator. Additionally, we use the learned features for novel tasks - demonstrating their applicability as general image representations. This paper introduces a deep-learning approach to photographic style transfer that handles a large variety of image content while faithfully transferring the reference style. Our approach builds upon the recent work on painterly transfer that separates style from the content of an image by considering different layers of a neural network. However, as is, this approach is not suitable for photorealistic style transfer. Even when both the input and reference images are photographs, the output still exhibits distortions reminiscent of a painting. Our contribution is to constrain the transformation from the input to the output to be locally affine in colorspace, and to express this constraint as a custom fully differentiable energy term. We show that this approach successfully suppresses distortion and yields satisfying photorealistic style transfers in a broad variety of scenarios, including transfer of the time of day, weather, season, and artistic edits. Rendering the semantic content of an image in different styles is a difficult image processing task. Arguably, a major limiting factor for previous approaches has been the lack of image representations that explicitly represent semantic information and, thus, allow to separate image content from style. Here we use image representations derived from Convolutional Neural Networks optimised for object recognition, which make high level image information explicit. We introduce A Neural Algorithm of Artistic Style that can separate and recombine the image content and style of natural images. The algorithm allows us to produce new images of high perceptual quality that combine the content of an arbitrary photograph with the appearance of numerous wellknown artworks. Our results provide new insights into the deep image representations learned by Convolutional Neural Networks and demonstrate their potential for high level image synthesis and manipulation.