Privacy is of the utmost importance in genomic matching. Therefore a number of privacy-preserving protocols have been presented using secure computation. Nevertheless, none of these protocols prevents inferences from the result. Goodrich has shown that this resulting information is sufficient for an effective attack on genome databases. In this paper we present an approach that can detect and mitigate such an attack on encrypted messages while still preserving the privacy of both parties. Note that randomization, e.g. using differential privacy, will almost certainly destroy the utility of the matching result. We combine two known cryptographic primitives -- secure computation of the edit distance and fuzzy commitments -- in order to prevent submission of similar genome sequences. Particularly, we contribute an efficient zero-knowledge proof that the same input has been used in both primitives. We show that using our approach it is feasible to preserve privacy in genome matching and also detect and mitigate Goodrich's attack.
The guaranteed randomization approach to prevent inferences about the input is differential privacy @cite_21 . A randomized function @math gives @math -differential privacy if, for all data sets @math and @math differing on at most one element and all @math , @math It means, that the likelihood of any function result will only marginally change with the presence or absence of one additional element.
@cite_21
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Over the past five years a new approach to privacy-preserving data analysis has born fruit [13, 18, 7, 19, 5, 37, 35, 8, 32]. This approach differs from much (but not all!) of the related literature in the statistics, databases, theory, and cryptography communities, in that a formal and ad omnia privacy guarantee is defined, and the data analysis techniques presented are rigorously proved to satisfy the guarantee. The key privacy guarantee that has emerged is differential privacy. Roughly speaking, this ensures that (almost, and quantifiably) no risk is incurred by joining a statistical database. In this survey, we recall the definition of differential privacy and two basic techniques for achieving it. We then show some interesting applications of these techniques, presenting algorithms for three specific tasks and three general results on differentially private learning.