This paper addresses the challenge of localization of anatomical landmarks in knee X-ray images at different stages of osteoarthritis (OA). Landmark localization can be viewed as regression problem, where the landmark position is directly predicted by using the region of interest or even full-size images leading to large memory footprint, especially in case of high resolution medical images. In this work, we propose an efficient deep neural networks framework with an hourglass architecture utilizing a soft-argmax layer to directly predict normalized coordinates of the landmark points. We provide an extensive evaluation of different regularization techniques and various loss functions to understand their influence on the localization performance. Furthermore, we introduce the concept of transfer learning from low-budget annotations, and experimentally demonstrate that such approach is improving the accuracy of landmark localization. Compared to the prior methods, we validate our model on two datasets that are independent from the train data and assess the performance of the method for different stages of OA severity. The proposed approach demonstrates better generalization performance compared to the current state-of-the-art.
The proposed approach is related to the regression-based methods for keypoint localization @cite_7 . We utilize an hourglass network which is an encoder-decoder model initially introduced for human pose estimation @cite_34 and address both ROI and landmark localization tasks. Several other studies in medical imaging domain also leveraged a similar approach by applying U-Net @cite_38 to the landmark localization problem @cite_37 @cite_0 . However, the encoder-decoder networks are computationally heavy during the training phase since they regress a tensor of high-resolution heatmaps which is challenging for medical images that are typically of a large size. It is notable that decreasing the image resolution could negatively impact the accuracy of landmark localization. In addition, most of the existing approaches use a refinement step which makes the computational burden even harder to cope with. Nevertheless, hourglass CNNs are widely used in human pose estimation @cite_34 due to a possibility of lowering down the resolution and the absence of precise ground truth.
@cite_38 @cite_37 @cite_7 @cite_0 @cite_34
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There is large consent that successful training of deep networks requires many thousand annotated training samples. In this paper, we present a network and training strategy that relies on the strong use of data augmentation to use the available annotated samples more efficiently. The architecture consists of a contracting path to capture context and a symmetric expanding path that enables precise localization. We show that such a network can be trained end-to-end from very few images and outperforms the prior best method (a sliding-window convolutional network) on the ISBI challenge for segmentation of neuronal structures in electron microscopic stacks. Using the same network trained on transmitted light microscopy images (phase contrast and DIC) we won the ISBI cell tracking challenge 2015 in these categories by a large margin. Moreover, the network is fast. Segmentation of a 512x512 image takes less than a second on a recent GPU. The full implementation (based on Caffe) and the trained networks are available at http: lmb.informatik.uni-freiburg.de people ronneber u-net . The locations of the fiducial facial landmark points around facial components and facial contour capture the rigid and non-rigid facial deformations due to head movements and facial expressions. They are hence important for various facial analysis tasks. Many facial landmark detection algorithms have been developed to automatically detect those key points over the years, and in this paper, we perform an extensive review of them. We classify the facial landmark detection algorithms into three major categories: holistic methods, Constrained Local Model (CLM) methods, and the regression-based methods. They differ in the ways to utilize the facial appearance and shape information. The holistic methods explicitly build models to represent the global facial appearance and shape information. The CLMs explicitly leverage the global shape model but build the local appearance models. The regression based methods implicitly capture facial shape and appearance information. For algorithms within each category, we discuss their underlying theories as well as their differences. We also compare their performances on both controlled and in the wild benchmark datasets, under varying facial expressions, head poses, and occlusion. Based on the evaluations, we point out their respective strengths and weaknesses. There is also a separate section to review the latest deep learning based algorithms. The survey also includes a listing of the benchmark databases and existing software. Finally, we identify future research directions, including combining methods in different categories to leverage their respective strengths to solve landmark detection "in-the-wild". Abstract In many medical image analysis applications, only a limited amount of training data is available due to the costs of image acquisition and the large manual annotation effort required from experts. Training recent state-of-the-art machine learning methods like convolutional neural networks (CNNs) from small datasets is a challenging task. In this work on anatomical landmark localization, we propose a CNN architecture that learns to split the localization task into two simpler sub-problems, reducing the overall need for large training datasets. Our fully convolutional SpatialConfiguration-Net (SCN) learns this simplification due to multiplying the heatmap predictions of its two components and by training the network in an end-to-end manner. Thus, the SCN dedicates one component to locally accurate but ambiguous candidate predictions, while the other component improves robustness to ambiguities by incorporating the spatial configuration of landmarks. In our extensive experimental evaluation, we show that the proposed SCN outperforms related methods in terms of landmark localization error on a variety of size-limited 2D and 3D landmark localization datasets, i.e., hand radiographs, lateral cephalograms, hand MRIs, and spine CTs. This work introduces a novel convolutional network architecture for the task of human pose estimation. Features are processed across all scales and consolidated to best capture the various spatial relationships associated with the body. We show how repeated bottom-up, top-down processing used in conjunction with intermediate supervision is critical to improving the performance of the network. We refer to the architecture as a “stacked hourglass” network based on the successive steps of pooling and upsampling that are done to produce a final set of predictions. State-of-the-art results are achieved on the FLIC and MPII benchmarks outcompeting all recent methods.