This paper is motivated by the comparison of genetic networks based on microarray samples. The aim is to test whether the differences observed between two inferred Gaussian graphical models come from real differences or arise from estimation uncertainties. Adopting a neighborhood approach, we consider a two-sample linear regression model with random design and propose a procedure to test whether these two regressions are the same. Relying on multiple testing and variable selection strategies, we develop a testing procedure that applies to high-dimensional settings where the number of covariates @math is larger than the number of observations @math and @math of the two samples. Both type I and type II errors are explicitely controlled from a non-asymptotic perspective and the test is proved to be minimax adaptive to the sparsity. The performances of the test are evaluated on simulated data. Moreover, we illustrate how this procedure can be used to compare genetic networks on Hess breast cancer microarray dataset.
The literature on high-dimensional two-sample tests is very light. In the context of high-dimensional two-sample comparison of means, @cite_3 @cite_42 @cite_34 @cite_2 have introduced global tests to compare the means of two high-dimensional Gaussian vectors with unknown variance. Recently, @cite_24 @cite_8 developped two-sample tests for covariance matrices of two high-dimensional vectors.
@cite_8 @cite_42 @cite_3 @cite_24 @cite_2 @cite_34
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We propose two tests for the equality of covariance matrices between two high-dimensional populations. One test is on the whole variance-covariance matrices, and the other is on offdiagonal sub-matrices which define the covariance between two non-overlapping segments of the high-dimensional random vectors. The tests are applicable (i) when the data dimension is much larger than the sample sizes, namely the “large p, small n” situations and (ii) without assuming parametric distributions for the two populations. These two aspects surpass the capability of the conventional likelihood ratio test. The proposed tests can be used to test on covariances associated with gene ontology terms. In this paper, we consider a test for the mean vector of independent and identically distributed multivariate normal random vectors where the dimension p is larger than or equal to the number of observations N. This test is invariant under scalar transformations of each component of the random vector. Theories and simulation results show that the proposed test is superior to other two tests available in the literature. Interest in such significance test for high-dimensional data is motivated by DNA microarrays. However, the methodology is valid for any application which involves high-dimensional data. In the high-dimensional setting, this article considers three interrelated problems: (a) testing the equality of two covariance matrices and ; (b) recovering the support of ; and (c) testing the equality of and row by row. We propose a new test for testing the hypothesis H 0: and investigate its theoretical and numerical properties. The limiting null distribution of the test statistic is derived and the power of the test is studied. The test is shown to enjoy certain optimality and to be especially powerful against sparse alternatives. The simulation results show that the test significantly outperforms the existing methods both in terms of size and power. Analysis of a prostate cancer dataset is carried out to demonstrate the application of the testing procedures. When the null hypothesis of equal covariance matrices is rejected, it is often of significant interest to further investigate how they differ from each other. Motivated by applications in genomics, we also consider recovering the support of and ... We consider the hypothesis testing problem of detecting a shift between the means of two multivariate normal distributions in the high-dimensional setting, allowing for the data dimension p to exceed the sample size n. Specifically, we propose a new test statistic for the two-sample test of means that integrates a random projection with the classical Hotelling T^2 statistic. Working under a high-dimensional framework with (p,n) tending to infinity, we first derive an asymptotic power function for our test, and then provide sufficient conditions for it to achieve greater power than other state-of-the-art tests. Using ROC curves generated from synthetic data, we demonstrate superior performance against competing tests in the parameter regimes anticipated by our theoretical results. Lastly, we illustrate an advantage of our procedure's false positive rate with comparisons on high-dimensional gene expression data involving the discrimination of different types of cancer. We proposed a two sample test for means of high dimensional data when the data dimension is much larger than the sample size. The classical Hotelling's @math test does not work for this large p, small n" situation. The proposed test does not require explicit conditions on the relationship between the data dimension and sample size. This offers much flexibility in analyzing high dimensional data. An application of the proposed test is in testing significance for sets of genes, which we demonstrate in an empirical study on a Leukemia data set.