RIPPER: a framework for MS1 only metabolomics and proteomics label free relative quantification
UNLABELLED RIPPER is a framework for mass spectrometry based label free relative quantification for proteomics and metabolomics studies. RIPPER combines a series of previously described algorithms for pre processing, analyte quantification, retention time alignment, and analyte grouping across runs. It is also the first software framework to implement proximity based intensity normalization. RIPPER produces lists of analyte signals with their unnormalized and normalized intensities that can serve as input to statistical and directed mass spectrometry (MS) methods for detecting quantitative differences between biological samples using MS. AVAILABILITY AND IMPLEMENTATION http:/www.z.umn.edu/ripper CONTACT vanr0014@umn.edu SUPPLEMENTARY INFORMATION Supplementary data are available at Bioinformatics online.
Bioinform.