Genetic variant rs4072037 of MUC1 and gastric cancer risk in an Eastern Chinese population
Published data on the association between the MUC1 rs4072037A G polymorphism and gastric cancer (GCa) risk were inconclusive. To derive a more precise estimation of the association, we conducted a large GCa study of 1,124 cases and 1,192 controls to confirm this association in an Eastern Chinese population. Our results showed that the G allele was strongly associated with a decreased GCa risk in the study population [GG vs. AA, odds ratio (OR) 0.47, 95% confidence interval (CI) 0.31 0.73; AG/GG vs. AA, OR 0.82, 95% CI 0.68 0.99; GG vs. AA/AG, OR 0.48, 95% CI 0.32 0.74] These associations remained significant in subgroups of age, tumor site, drinking and smoking status. Moreover, this association was supported by an additional meta analysis of published studies. In summary, these results suggest that the MUC1 rs4072037G allele may be a low penetrating protection factor for GCa risk in Chinese populations.
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