Evaluation of Antifungal and Antibacterial Activity and Analysis of Bioactive Phytochemical Compounds of Cinnamomum Zeylanicum (Cinnamon Bark) using Gas Chromatography Mass Spectrometry
Phytochemicals are chemical compounds often referred to as secondary metabolites. Thirty nine bioactive phytochemical compounds were identified in the methanolic extract of Cinnamon bark. The identification of phytochemical compounds is based on the peak area, retention time molecular weight and molecular formula. GC MS analysis of Cinnamomum zeylanicum revealed the existence of the 6 Oxa bicyclo[3.1.0]hexan 3 one, Benzaldehyde, Cyclohexene,4isopropenyl 1 methoxymethoxymethyl, Benzoic acid methyl ester, Benzaldehyde dimethyl acetal, Benzenepropanal, Benzylidenemalonaldehyde, 3 Phenylpropanol, Cinnamaldehyde, (E) 2 Propen 1 ol,3 phenyl, 9 Methoxybicyclo[6.1.0]nona 2,4,6 triene 1,3 Bis(cinnamoyloxymethyl) adamantine, Alfa. Copaene, Naphthalene 1,2,3,5,6,7,8,8a octahydro 1,8a dimethyl 7 (1 methyl) Cis 2 Methoxycinnamic acid, Bicyclo[3.1.1]hept 2 ene,2,6 dimethyl 6 (4 methyl 3 pentenyl) Trans 2 Hydroxycinnamic acid methyl ester, y Muurolene, s Guaiene, Cadala 1(10),3,8 triene, Isolongifolene,4,5,9,10 dehydro, Cubenol, Tau Muurolol, A Cadinol Spiro[tricyclo[4.4.0.0(5.9) decane 10.2oxirane],1 methyl 4 isoprol, 6 Isopropenyl 4,8q dimethyl 1,2,3,5,6,7,8,8aoctahydronaphthalen, Ethyl9,9 difomylnona 2,4,6,8 tetraenoate, Trans 13 Octadecenoic acid, Tributyl acetylcitrate, 9,12,15 Octadecatrienoic acid ,2,3 dihydroxypropyl ester, 9 Octadecenamide, 17.alfa. 21s 28,30 Bisnorhopane, 17.alfa. 21s 28,30 Bisnorhopane, Androstan 3 one,cyclic 1,2ethanediyl mercaptole (5a) (4H)4a,5,6,7,8,8a Hexahydrobenzopyran 5 one 3 carboxamide,2, 4H Cyclopropa[5',6']benz [1',2',7,8]azuleno[5,6]oxiren 4 one,8,8a, (22S) 21 Acetoxy 6a,11sdihydroxy 16a,17a propylmethylenediox, a Tocopherol,O methyl and Stigmasterol. Cinnamomum zeylanicum contain chemical constitutions which may be useful for various herbal formulation as anti inflammatory, analgesic, antipyretic, cardiac tonic and antiasthamatic. Cinnamomum zeylanicum was highly active against Aspergillus flavus (6.16+ 0.42) Methanolic extract of bioactive compounds of Cinnamomum zeylanicum was assayed for in vitro antibacterial activity against Pseudomonas aerogenosa, Escherichia coli, Proteus mirabilis, Staphylococcus aureus and Klebsiella pneumonia by using the diffusion method in agar. The zone of inhibition were compared with different standard antibiotics. The diameters of inhibition zones ranged from 6.12+ 0.52 to 0.39+ 0.17 mm for all treatments.