Using Fourier transform infrared spectroscopy to evaluate biological effects induced by photodynamic therapy
Vibrational spectroscopic methods associated with multivariate statistical techniques have been succeeded in discriminating skin lesions from normal tissues. However, there is no study exploring the potential of these techniques to assess the alterations promoted by photodynamic effect in tissue. The present study aims to demonstrate the ability of Fourier Transform Infrared (FTIR) spectroscopy on Attenuated total reflection (ATR) sampling mode associated with principal component linear discriminant analysis (PC LDA) to evaluate the biochemical changes caused by photodynamic therapy (PDT) in skin neoplastic tissue.
Lasers in surgery and medicine