Serum nesfatin 1 levels in patients with different glucose tolerance levels.
The aim of this study was to compare the levels of nesfatin 1 in healthy subjects with those in prediabetic and diabetic patients who have different glucose tolerance levels. Overall, 100 subjects were divided into 5 groups healthy control (C) impaired fasting glycemia (IFG) impaired glucose tolerance (IGT) metabolic syndrome (MS) and type 2 diabetes mellitus, (Type 2 DM) Glycated hemoglobin (HbA1c) assessed the glycemic control. Homeostasis model assessment of insulin resistance (HOMA IR) was determined using computer analyses. Nesfatin 1 levels were measured using ELISA method. IFG and IGT (prediabetic groups) from MS and Type 2 DM (diabetic groups) differed significantly in HOMA IR. The nesfatin 1 levels were lower, although not statistically significant, in IFG (0.937+ 0.03 ng/ml, p=0.07) and IGT (1.039+ 0.06 ng/ml, p=0.5) groups compared to healthy subjects (1.094+ 0.07 ng/ml) However, the nesfatin 1 levels were lower in patients with Type 2 DM (0.867+ 0.02 ng/ml, p=0.007) and MS (0.885+ 0.01 ng/ml, p=0.01) compared to healthy subjects. Nesfatin 1 levels were significantly lower in diabetic patients compared to healthy subjects. This study supports the role of insulin resistance in decreased nesfatin 1 levels in patients with Type 2 DM and MS.
Physiological research