Correlation of serum ANA and direct immunofluorescence studies in elderly Thai patients with red and white oral lesions.
OBJECTIVES This study investigated the presence of serum antinuclear antibodies (ANA) profile and direct immunofluorescence (DIF) evaluation in elderly Thai patients with red and white oral lesions. MATERIALS AND METHODS Thirty two patients with red and white oral lesions were divided into two groups: group I consisted of 10 cases not taking medications, while group II consisted of 12 cases taking medications, and 30 healthy subjects as a control group. Blood samples were used to determine the ANA profile. DIF was investigated in the lesion containing groups. RESULTS Serum ANA was found in six cases (60% in group I, eight cases (66.7% in group II, and 19 cases (63.3% in the control group. There were no significant differences between group I and group II and the control group (P 0.05) Serum ANA was most commonly found in patients taking hypolipidemics (80% followed by antihypertensives (71.4% NSAIDs (50% hypoglycemics (50% and others (66.7% The anticytoplasmic staining frequency in group II was higher compared with group I and the control group. Anti dsDNA antibodies were not found in any group. CONCLUSIONS Elderly patients with red and white oral lesions who were taking medications had a higher serum ANA frequency than group I and the control group.
Journal of oral pathology medicine official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology