Comparison of the effects of Mitomycin C and sodium hyaluronate/carboxymethylcellulose [NH/CMC] (Seprafilm) on abdominal adhesions
IntroductionIntra abdominal adhesions (IA) may occur after abdominal surgery and also may lead to complications such as infertility, intestinal obstruction and chronic pain. The aim of this study was to compare the effects of Mitomycin C (MM C) and sodium hyaluronate/carboxymethylcellulose [NH/CMC] on abdominal adhesions in a cecal abrasion model and to investigate the toxicity of MM C on complete blood count (CBC) and bone marrow analyses.MethodsThe study comprised forty rats in four groups (Control, Sham, Cecal abrasion MM C, and Cecal abrasion NH/CMC) On postoperative day 21, all rats except for the control (CBC femur resection) group, were sacrificed. Macroscopical and histopathological evaluations of abdominal adhesions were performed. In order to elucidate the side effects of MM C; CBC analyses and femur resections were performed to examine bone marrow cellularity.ResultsCBC analyses and bone marrow cellularity assessment revealed no statistically significant differences between MM C, NH/CMC and control groups. No significant differences in inflammation scores were observed between the groups. The MM C group had significantly lower fibrosis scores compared to the NH/CMC and sham groups. Although the adhesion scores were lower in the MM C group, the differences were not statistically significant.ConclusionDespite its potential for systemic toxicity, MM C may show some anti fibrosis and anti adhesive effects. MM C is a promising agent for the prevention of IAs, and as such, further trials are warranted to study efficacy.
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