Local RhoA activation induces cytokinetic furrows independent of spindle position and cell cycle stage
Using optogenetics to obtain spatiotemporal control of RhoA activation, Wagner and Glotzer show that local RhoA activation is sufficient to induce cytokinetic furrowing. Furrows can be induced at both the cell equator and cell poles during various stages of mitosis, and cell rounding allows active RhoA to induce furrows in interphase.
The Journal of cell biology