Therapeutic effects of ellagic acid on L arginin induced acute pancreatitis.
PURPOSE To investigate the therapeutic effects of ellagic acid on L arginin induced acute pancreatitis in rats. METHODS Thirty two were split into four groups. Group 1 (control) rats were performed only laparotomy, no drugs were administered. Group 2 (control+EA) rats were administered 85mg/kg EA orally. Rats were sacrificed by cardiac puncture 24 hours after the administration. Group3 (AP) 24 hours after intraperitoneal L arginine administration, rats were sacrificed by cardiac puncture. Group 4 (EA) (AP) 85mg/kg EA was administered orally after the L arginine administration. 24 hours later, rats were sacrificed by cardiac puncture. Serum TNF a, IL 1b, IL 6, total oxidative status (TOS) total antioxidant capacity (TAC) amylase levels were determined in all groups. RESULTS Group 3 (AP) rats showed significantly raised TOS level as compared to Group1 (control) rats (p<0.001) Following the EA therapy, a decrease in TOS was observed in Group 4 (AP+EA) TAC levels were significantly raised in the Group 4 (AP+EA) compared to the Group 3 (AP) (p=0.003) Group 3 (AP) showed significantly increased TNF a, IL 1b and IL 6 serum levels as compared to Group 4 (AP+EA) Histopathological changes were supported our result. CONCLUSION The healing effects of ellagic acid on inflammatory and oxidative stress were confirmed by histopathological and biochemical evaluations of the pancreatic tissue.
Acta cirurgica brasileira