Beta Adrenoceptor Antagonists and Antianginal Drugs
Abstract This review of the 2015 publications on beta adrenoceptor antagonists and antianginal drugs covers beta adrenoceptor antagonists, calcium channel blockers, the potassium channel activator nicorandil, nitroglycerin, and the late sodium channel (INA) inhibitor ranolazine. Highlights include reports of a pityriasis rosea like reaction with atenolol, acute generalized exanthematous pustulosis with labetalol, psychosis with metoprolol, gynecomastia with nebivolol, fatal hyperkalemia with concomitant propranolol and succinylcholine, and psychosis with topical timolol. Studies reporting a lack of increased fracture risk of elderly patients on calcium channel blockers coprescribed clarithromycin, reduced vasodilatory side effects and headache with combination nifedipine candesartan, and lack of hypotension in aortic stenosis patients receiving nitroglycerin are described. Case reports of intractable hyperkalemia from nicorandil, Schamberg's disease with amlodipine, gingival overgrowth with nitrendipine and amlodipine, and T wave inversions with ranolazine are also included.