Self assembled IR780 loaded transferrin nanoparticles as an imaging, targeting and PDT/PTT agent for cancer therapy
Combination of photothermal and photodynamic therapy (PTT/PDT) offer unique advantages over PDT alone. However, to achieve synergetic PDT/PTT effect, one generally needs two lasers with different wavelengths. Near infrared dye IR 780 could be used as photosensitizer both for PTT and PDT, but its lipophilicity limits its practical use and in vivo efficiency. Herein, a simple multifunctional IR780 loaded nanoplatform based on transferrin was developed for targeted imaging and phototherapy of cancer compatible with a single NIR laser irradiation. The self assembled transferrin IR780 nanoparticles (Tf IR780 NPs) exhibited narrow size distribution, good photo stability, and encouraging photothermal performance with enhanced generation of ROS under laser irradiation. Following intravenous injection, Tf IR780 NPs had a high tumor to background ratio in CT26 tumor bearing mice. Treatment with Tf IR780 NPs resulted in significant tumor suppression. Overall, the Tf IR780 NPs show notable targeting and theranostic potential in cancer therapy.
Scientific reports