Thiol modified gold coated glass as an efficient hydrophobic substrate for drop coating deposition Raman (DCDR) technique
In this paper we report an easy and low cost way to prepare a hydrophobic substrate for drop coating deposition Raman (DCDR) spectroscopy. This substrate is formed by a thiol modified Au coated glass and provides the Raman spectra with the same quality as the commercial Teflon coated stainless steel substrate (SpectRIM(tm) Tienta Sciences, Inc. for model molecular systems albumin solution and liposome suspension. Gold layer, similarly to polished steel in the commercial substrate, served as a highly refractive layer strongly increasing the Raman signal. The main advantage of introduced substrate is that it is simple and a low cost preparation easily manageable in every standard laboratory. Thus, it represents a promising alternative to commercial Teflon coated stainless steel substrate. Copyright (c) 2016 John Wiley Sons, Ltd.