Lactobacillus plantarum TWK10 Supplementation Improves Exercise Performance and Increases Muscle Mass in Mice
Lactobacillus plantarum (L. plantarum) is a well known probiotic among the ingested microorganism probiotics (i.e. ingested microorganisms associated with beneficial effects for the host) However, few studies have examined the effects of L. plantarum TWK10 (LP10) supplementation on exercise performance, physical fatigue, and gut microbial profile. Male Institute of Cancer Research (ICR) strain mice were divided into three groups (n 8 per group) for oral administration of LP10 for six weeks at 0, 2.05 x 108, or 1.03 x 109 colony forming units/kg/day, designated the vehicle, LP10 1X and LP10 5X groups, respectively. LP10 significantly decreased final body weight and increased relative muscle weight LP10 supplementation dose dependently increased grip strength (p 0.0001) and endurance swimming time (p 0.001) and decreased levels of serum lactate (p 0.0001) ammonia (p 0.0001) creatine kinase (p 0.0118) and glucose (p 0.0151) after acute exercise challenge. The number of type I fibers (slow muscle) in gastrocnemius muscle significantly increased with LP10 treatment. In addition, serum levels of albumin, blood urea nitrogen, creatinine, and triacylglycerol significantly decreased with LP10 treatment. Long term supplementation with LP10 may increase muscle mass, enhance energy harvesting, and have health promotion, performance improvement, and anti fatigue effects.
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