Matrix metalloproteinase gene polymorphisms and periodontitis susceptibility: a meta analysis involving 6,162 individuals
We aimed to systematically investigate the potential association of matrix metalloproteinase (MMP) 9, 3, 2, and 8 gene polymorphisms with susceptibility to periodontitis using meta analysis. A literature search in PubMed, Embase, and Web of Sciencewas conducted to obtain relevant publications. Finally a total of 16 articles with 24 case control studies (nine on MMP 9 1562 C/T, seven on MMP 3 1171 A5/A6, four on MMP 2 753C/T, and four on MMP 8 799 C/T) were considered in this meta analysis. The results based on 2,724 periodontitis patients and 3,438 controls showed that MMP 9 1562C/T, MMP 3 1171 A5/A6, and MMP 8 799C/T polymorphisms were associated with periodontitis susceptibility. No significant association was found between MMP 2 753 C/T and periodontitis susceptibility. Subgroup analyses suggested that the MMP 9 1562 C/T polymorphism reduced chronic periodontitis susceptibility and MMP 3 1171 A5/A6polymorphism increased chronic periodontitis susceptibility. In summary, current evidence demonstrated that MMP 9 753 C/Tpolymorphism reduced the risk of periodontitis, MMP 3 1171 5A/6A and MMP 8 799 C/Tpolymorphisms increased the risk of periodontitis, and MMP 2 753 C/T was not associated with risk of periodontitis.
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