A New Dioic Acid from a wbl Gene Mutant of Deepsea Derived Streptomyces somaliensis SCSIO ZH66
The wblAso gene functions as a global regulatory gene in a negative manner in deepsea derived Streptomyces somaliensis SCSIO ZH66. A new dioic acid (1) as well as two known butenolides (2 and 3) were isolated from the DwblAso mutant strain of S. somaliensis SCSIO ZH66. The structure of 1 was elucidated by a combination of spectroscopic analyses, including MS and NMR techniques. In the cell growth inhibitory evaluation, compound 3 exhibited moderate activity against the human hepatic carcinoma cell line (Huh7.5) with an IC50 value of 19.4 mg/mL, while compounds 1 and 2 showed null activity up to 100 mg/mL.
Marine drugs