Human disorders of peroxisome metabolism and biogenesis.
Peroxisomes are dynamic organelles that play an essential role in a variety of cellular catabolic and anabolic metabolic pathways, including fatty acid alpha and beta oxidation, and plasmalogen and bile acid synthesis. Defects in genes encoding peroxisomal proteins can result in a large variety of peroxisomal disorders either affecting specific metabolic pathways, i.e. the single peroxisomal enzyme deficiencies, or causing a generalized defect in function and assembly of peroxisomes, i.e. peroxisome biogenesis disorders. In this review, we discuss the clinical, biochemical, and genetic aspects of all human peroxisomal disorders currently known.
Biochimica et biophysica acta