Palladium catalyzed direct C H arylation of pyridine N oxides with potassium aryl and heteroaryltrifluoroborates.
An efficient ligand free Pd(OAc)2 catalyzed selective arylation of pyridine N oxides using potassium (hetero)aryltrifluoroborates as coupling partners via C H bond activation was achieved in the presence of TBAI. This approach has a broad substrate scope and shows moderate to high yields.
Organic biomolecular chemistry