A Case of Cancer associated Dermatomyositis in a Patient with Thymic Carcinoma
Background. Thymic carcinoma is a cause of a cancer associated dermatomyositis. Case. A 73year old female was referred to our hospital with sudden onset dermatitis and was diagnosed with dermatomyositis. Since steroid therapy was accompanied by the waxing and waning of the patient's skin symptoms, cancerassociated dermatomyositis was suspected. Chest computed tomography revealed a lobular anterior mediastinal tumor of 42 mm in diameter with mediastinal and supraclavicular lymphadenopathy. Thymectomy with resection of the invaded pericardium and left brachiocephalic vein and lymphadenectomy were performed via median sternotomy. A pathological examination revealed a poorly differentiated squamous cell carcinoma of the thymus with metastatic lymph nodes (pT1aN2M0, stage IVb) Although the clinical symptoms of dermatomyositis were ameliorated soon after resection, the patient's skin rashes worsened after the recurrence of thymic carcinoma. Conclusion. The abrupt development of symptoms and the remission of skin symptoms in response to the therapeutic process were helpful as evidence of thymic cancer associated dermatomyositis. (JJLC. 2016;56:189 193) KEY WORDS Thymic carcinoma, Dermatomyositis, Paraneoplastic syndrome Corresponding author: Minoru Aoki. Received December 1, 2015; accepted February 29, 2016. Yao Zhi Bei Jing .Xiong Xian Yan haE Xing Zhong Yang Guan Lian Pi Fu Jin Yan noYuan Yin tonariDe ru.Zheng Li .73 Sui ,Nu Xing .Pi Fu Jin Yan woJi Su niFa Zheng shi,suteroidoZhi Liao woKai Shi sareta.Zheng Zhuang gaAn Ding shinaita meE Xing Zhong Yang He Bing woYi tsuta.Jing Cha Shi niXiong Bu CTniteQian Zong Ge niChang Jing 42 mmnoFen Xie Zhuang noJie Jie oyobiZong Ge ,Suo Gu Shang Wo rin paJie Zhong Da woZhi Zhai sareta.Zhen Duan toZhi Liao woJian netaXiong Gu Zheng Zhong Qie Kai Qian Zong Ge Zhong Yang Qie Chu Shu ,Kuo Da Xiong Xian Zhai Chu Shu ,Xin Mo Zong Ge Xiong Mo Zuo Wan Tou Jing Mo He Bing Qie Chu Shu ,rinpaJie Guo Qing Shu gaXing wareta.Bing Li Zu Zhi Jian Cha deharinpaJie Zhuan Yi woBan uXiong Xian Yuan Fa Bian Ping Shang Pi Yan (pT1aN2M0,stage IVb)toZhen Duan sareta.Pi Fu Jin Yan Zheng Zhuang ha Shu Hou Su yakaniGai Shan shitaga,Shu Hou 4kaYue Hou niGan Zhuan Yi Zai Fa wo Ren me,Yi Hou Pi Fu Zheng Zhuang gaZai Zeng E shita.Jie Yu .Ben Zheng Li noPi Fu Jin Yan ha,Tu Ran noFa Zheng ,Qie Chu Hou noGai Shan ,Zai Fa Shi noZai Zeng E no tame,Xiong Xian Yan niSui Ban suruBing Tai toKao eta. Suo Yin Yong Yu Xiong Xian Yan ,Pi Fu Jin Yan ,Zhong Yang Sui Ban Zheng Hou Qun