A 18F labeled dibenzocyclooctyne (DBCO) derivative for copper free click labeling of biomolecules
The new prosthetic group 18F TEG DBCO (dibenzocyclooctyne) can be prepared within a total reaction time of 60 min including purification with an overall yield (n.d.c. of 34 5% Copper free click cycloadditions with an azido cRGD, a folate azide and two a MSH analogue azido peptides resulted in very high RCYs and fast reaction kinetics.