Maternal glucose intolerance reduces offspring nephron endowment and increases glomerular volume in adult offspring
Animal studies report a nephron deficit in offspring exposed to maternal diabetes, yet are limited to models of severe hyperglycaemia which do not reflect the typical clinical condition and which are associated with foetal growth restriction that may confound nephron endowment. We aimed to assess renal morphology and function in offspring of leptin receptor deficient mice (Leprdb/ and hypothesized that exposure to impaired maternal glucose tolerance (IGT) would be detrimental to the developing kidney.
Diabetes/metabolism research and reviews