Dietary Nanosized Lactobacillus plantarum Enhances the Anticancer Effect of Kimchi on Azoxymethane and Dextran Sulfate Sodium Induced Colon Cancer in C57BL/6J Mice.
This study was undertaken to evaluate enhancement of the chemopreventive properties of kimchi by dietary nanosized Lactobacillus (Lab.)plantarum (nLp) in an azoxymethane (AOM)/dextran sulfate sodium (DSS) induced colitis associated colorectal cancer C57BL/6J mouse model. nLp is a dead, shrunken, processed form of Lab. Plantarum isolated from kimchi that is 0.5 1.0 um in size. The results obtained showed that animals fed kimchi with nLp (K nLp) had longer colons and lower colon weights/length ratios and developed fewer tumors than mice fed kimchi alone (K) In addition, K nLp administration reduced levels of proinflammatory cytokine serum levels and mediated the mRNA and protein expressions of inflammatory, apoptotic, and cell cycle markers to suppress inflammation and induce tumor cell apoptosis and cell cycle arrest. Moreover, it elevated natural killer cell cytotoxicity. The study suggests adding nLp to kimchi could improve the suppressive effect of kimchi on AOM/DSS induced colorectal cancer. These findings indicate nLp has potential use as a functional chemopreventive ingredient in the food industry.
Journal of environmental pathology, toxicology and oncology official organ of the International Society for Environmental Toxicology and Cancer