EMSA Eritin polyherbal can suppress NF kB activation and decrease IL 17 cytokine in an irradiated mice model
ABSTRACT EMSA Eritin which consists of red rice, soybean, and coconut water extract has been widely reported as having antioxidant activity. This study aimed to analyse the effect of EMSA Eritin on nuclear factor (NF) kB activation and pro inflammatory cytokines IL 17 after radiation exposure. The experiments were carried out in the irradiated mouse model (6 Gy) Oral administration of EMSA Eritin 1.04, 3.125, and 9.375 mg/g BW for 14 days was compared with injections of 4.16 mg Erythropoietin aTM (EPO) This study shows an increase in NF kB activation and IL 17 production in irradiated mice compared to normal mice (p .05) EPO injection could not prevent these changes. Oral administration of EMSA Eritin suppressed NF kB activation, and also decreased production of pro inflammatory IL 17 significantly (p .05) compared with irradiated mice and irradiated mice treated with EPO.