A Cu catalyzed four component cascade reaction to construct b ester g amino ketones.
Herein, a novel Cu catalyzed four component cascade reaction, which encompasses styrenes, diazo compounds, amines, and tert butyl hydroperoxide (TBHP) was developed for the synthesis of b ester g amino ketones. Mechanistically, this transformation was initiated by the interception of an electrophilic Cu based carbene with nucleophilic a aminoalkyl radicals, followed by a radical cascade process and an ionic Kornblum DeLaMare reaction. The methodology was also distinguished by its wide substrate scope, easily available starting materials, and operational simplicity.
Organic biomolecular chemistry