Fatty acids, eicosanoids and PPAR gamma.
Peroxisome proliferator activated receptor g (PPARg) belongs to the family of nuclear nuclear receptors and is mainly expressed in adipose tissue, hematopoietic cells and the large intestine. Contrary to other nuclear receptors that mainly bind a single specific ligand, there are numerous natural PPARg ligands, in particular fatty acids or their derivatives called eicosanoids. PPARg have pleiotropic functions: (i) glucose and lipid metabolism regulation, (ii) anti inflammatory properties, (iii) oxidative stress inhibition, (iv) improvement of endothelial function. Its role has been mainly studied by the use synthetic agonists. In this review, we will focus on the effects of PPARg mediated through fatty acids and how these have beneficial health properties.
European journal of pharmacology