Vitamin D And Chronic Periodontitis A Randomised Double Blinded Placebo Controlled Parallel Clinical Trial
Background: Vitamin D is crucial for a wide variety of organ systems; nevertheless, evidence has demonstrated that vitamin D deficiency may place subjects at risk for not only low mineral bone density /osteoporosis and osteopenia but also infectious and chronic inflammatory diseases Vitamin D also has anti inflammatory effects by suppressing pro inflammatory cytokines through its effect on bone and mineral metabolism, innate immunity and several VDR gene polymorphisms, vitamin D has been reported to be associated with periodontal disease. Objectives: To assess anti inflammatory effect of vitamin D3, when administered as monotherapy in generalised chronic periodontitis. Methods: This study comprises of 56 patients of generalised chronic periodontitis who were screened for their serum vitamin D3 levels. Out of which 30 patients who were vitamin D3 deficient <20ng/ml) formed the study group. They were randomly given either vitamin D3 supplement or placebo. The Periodontal parameters and RVG were taken before treatment and post treatment after 2 months. Results: The results of this study indicate a probing pocket depth reduction in the vitamin D supplement group. The post treatment pocket depth is 5.3472 compared to 5.7661 in the pretreatment group. A correlation of 0.667 and statistically significant (p<0.002) reduction in pocket depth is noted. Clinical attachment gain in the post treatment group was 35.61 compared to the pre treatment mean value 33.72 indicat ing a statistically significant gain in the clinical attachment (p<0.000) Conclusion: Vitamin D deficiency may place subjects at risk for not only low bone mineral density/osteoporosis and osteopenia, but also infectious and chronic inflammatory diseases like periodontitis.