Association of type 1 diabetes mellitus and autoimmune disorders in Brazilian children and adolescents
Context: Type 1 diabetes mellitus (T1DM) is caused by an immune mediated destruction of pancreatic beta cells. Other autoimmune diseases can be observed in association with T1DM. The screening for celiac disease (CD) and Hashimoto's thyroiditis is necessary due to the increased prevalence of these pathologies in T1DM patients. Aims: This study aimed to investigate the prevalence of autoimmune markers for pancreatitis, thyroiditis, and CD in racially admixtured children and adolescents with T1DM. Settings and Design: Cross sectional clinic based study. Methods: Seventy one patients with T1DM (average: 11.6 5.1 years) In all patients, the following antibodies were surveyed: Anti glutamic acid decarboxylase (anti GAD) immunoglobulin A (IgA) anti transglutaminase (anti tTG) Antithyroglobulin (AAT) anti thyroid peroxidase (anti TPO) and IgA. Statistical Analysis Used: The quantitative variables were expressed as a mean and standard deviation and the qualitative variables in contingency tables. Student's t test and kh2 tests were used to assess the differences between the groups. The level of significance was established as P 0.05. Results: The prevalence of anti GAD antibodies was 5.9% anti tTG IgA, 7.4% anti TPO, 11.8% and AAT, 11.8% Conclusions: Children and adolescents with T1DM have increased the prevalence of antithyroid and CD related antibodies. The positivity for anti GAD and antithyroid antibodies was less frequent than in other studies. The prevalence of anti tTG antibodies was similar to the literature.
Indian journal of endocrinology and metabolism