Synthesis of Some Sulfa Drug Derivatives as Antibacterial Agents
Sulfonamides are an important class of synthetic bacteriostatic antibiotics still used today for the treatment of bacterial infections and those caused by other microorganisms. They are also known as sulfa drugs and were the main source of therapy against bacterial infections before the introduction of penicillin in 1941. Although sulfonamides have for the most part been replaced by other agents, they still maintain considerable action in certain types of infection, for example in the urinary tract, eye and ear, and bronchitis (Mok, 2008) The activity of the sulfa drugs has been extensively studied and can be explained in the following manner. Sulfonamides are typically administered in doses that are bacteriostatic, meaning they prevent or limit bacterial multiplication.