Specifically neuropathic Gaucher's mutations accelerate cognitive decline in Parkinson's
We hypothesized that specific mutations in the b glucocerebrosidase gene (GBA) causing neuropathic Gaucher's disease (GD) in homozygotes lead to aggressive cognitive decline in heterozygous Parkinson's disease (PD) patients, whereas non neuropathic GD mutations confer intermediate progression rates.
Annals of neurology