Clinicopathological evaluation of Prostatic Adenocarcinoma: A unicenter study
Background: Prostate cancer is a significant cause of morbidity and mortality. It ranks fifth in cancer incidence and fourth in cancer mortality in India. As the literature on the issue in India is limited, we undertook the study with the objective of evaluating the histopathological features of prostatic adenocarcinoma (PCa) and correlating these with certain clinicopathological variables. Methods: All the cases of PCa diagnosed on transurethral resection (TURP) specimens and core needle biopsies, over a period of three years (between January 2013 and January 2016) were evaluated. The clinicopathological data obtained was subjected to statistical analysis to discern correlations. Results: The study included 55 cases of PCa comprised of 29.1% of moderately differentiated, 18.2% of moderate to poorly differentiated and 52.7% of poorly differentiated cases. The mean patient age was 69 years with mean preoperative serum PSA level of 162.9 ng/ml. The three commonest clinical presenting symptoms were increased frequency of micturation (45.5% incomplete voiding (40% and dysuria (38.2% Gleason score 8 was the most frequent [15(27.3% followed by Gleason score 9 [13(23.6% The average tumour volume in TURP specimens and needle biopsies was 52.5 and 58.1% respectively. Conclusions: A positive correlation was found between high Gleason score and increased PSA levels and tumour volume. Majority of our patients had poorly differentiated PCa with high PSA levels suggesting that the disease is advanced at the time of diagnosis.