Characterizing the molecular interaction of perfluorocarbons with carbamazepine and benzodiazepine using photo acoustic studies
Abstract Lennox Gastaut syndrome (LGS) is commonly characterized by a triad of features including multiple seizure types, intellectual disability or regression. LGS type of seizures is epilepsy which is due to abnormal vibrations occurring in seizures. During the time of such abnormal vibrations, both the seizures and the lungs suffer a lack in oxygen content to a considerable extent. These result in prolonged vibrations and loss of nervous control. Perfluorodecalin C 10 F 18 (PFD) and perfluorohexane C 6 F 14 (PFH) which are excellent oxygen carriers are made as an interfacial solution with anti epileptic drugs (AEDs) such as carbamazepine and benzodiazepine with dimethylformamide (DMF) as common solvent. The interfacial solutions were subjected to ultrasonic laser diffraction (photo acoustical method) The experimentally measured data were plugged in classical mathematical models to analyze the complete molecular interactions. The estimated structure factor S(Q) and the L J potential parameter ph (r) reveals that both PFD and PFH co exist along with AEDs and support the purpose of this study, which is a neuro lung protective strategy.