Evaluation Qualitative des Comprimes d'Albendazole, de Mebendazole et de Praziquantel Commercialises dans la Ville de Yaounde
Introduction. Assurer la qualite des medicaments fabriques localement ou importes est fondamentale dans tout systeme de sante. Les tests de controle qualite permettent de garantir la qualite du medicament. Au Cameroun, plus de dix millions de personnes sont parasitees par les vers intestinaux et deux millions par les bilharzies. Le but de notre travail etait d'evaluer la qualite des comprimes d'antihelminthiques a base d'Albendazole, Mebendazole et Praziquantel commercialises dans les circuits formel et informel de la ville de Yaounde. Materiel et methodes. Nous avons realise une etude experimentale d'une duree de 7 mois utilisant comme referentiel, les normes des pharmacopees europeenne 8.0 IVeme edition et americaine 37NF32. Les echantillons de lots differents ont ete selectionnes selon une methode non aleatoire dans les circuits formel et informel. Les tests pharmacotechniques effectues concernaient l'etiquetage, visuel, durete, desagregation, friabilite, masse et dimensions. Les tests physicochimiques portaient sur l'identification et dosage des principes actifs. Resultats. Le Mexique (24,2% et l'Inde (18.1% etaient les pays avec le plus grand taux de non conformite. Tous les lieux d'approvisionnement ont ete concernes par la non conformite. les non conformites pharmacotechniques etaient: durete 17lots (58,6% friabilite 2lots (6,9% etiquetage 7lots (24.1% desagregation 5lots (17,2% et masse 1lot (3,6% Le dosage du principe actif (20% est le seul parametre physicochimique retrouve non conforme. Conclusion. Nos resultats ont montre que les non conformites (18,8% concernaient tous les circuits avec une majorite dans l'informel (24,8% contre 13,1% dans le formel. ABSTRACT Introduction. Ensuring the quality of drugs imported or produced locally is essential in the health care systems. Quality control tests can guarantee the quality of the drug. In Cameroon, more than ten million of persons are infected with intestinal parasitic worms and two million by bilhalzias. The purpose of our study was to evaluate the quality of anthelminthics tablets based on Albendazole, Mebendazole and Praziquantel sold in the formal and informal health care systems of Yaounde. Materials and methods. We carried out an experimental study within a period of 7 months using as reference, the various standards contained in the European 8.0 IVth Edition and American 37NF32 pharmacopoeias. The different samples were collected using a non random method from the formal and informal health care systems. The pharmacotechnical tests performed included labelling, visual, hardness, decomposition, friability, mass and dimensions. The physicochemical tests aimed at identifying and assessing the dose of active molecules. Results. Mexico (24.2% and India (18.1% being the countries with the highest prevalence of non compliance. All the sites where samples were collected were included in non compliance. The pharmacotechnical non compliant parameters were: hardness 17lots (58.6% friability 2lots (6.9% labelling 7lots (24.1% decomposition 5lots (17.2% and mass 1lot (3.6% The dose of active molecule 5lots (20% was the only non compliant physicochemical parameter. Conclusion. Our results showed that non compliance (18.8% was involved in both health care systems with the majority being informal (24.8% and the least being the formal (13.1%