Behavioral, cognitive, and motor performance and physical development of five year old children who were born after intracytoplasmic sperm injection with the use of testicular sperm.
OBJECTIVE To evaluate at the age of 5 years the behavioral, cognitive, and motor performance and physical development of children born after testicular sperm extraction (TESE) and intracytoplasmic sperm injection (ICSI) DESIGN A prospective longitudinal cohort study. SETTING Two university medical centers. PATIENT(S) A total of 103 5 year olds who were born after TESE ICSI. INTERVENTION(S) The follow up of the children was performed by questionnaires at birth and again at 1 year and at 4 years of age. Five year old children were invited for individual assessment. Behavioral performance was assessed with the use of the Child Behavior Checklist for parents and teachers. Cognitive performance was assessed with the use of the Dutch Wechsler Preschool and Primary Scale of Intelligence test, 3rd version. Motor performance was assessed with the use of the Dutch Movement Assessment Battery for Children, 2nd version. Physical development was assessed by means of physical examination and medical history. MAIN OUTCOME MEASURE(S) Behavioral, cognitive, and motor performance and physical development. RESULT(S) Eighty nine children were completely assessed, and 14 were partially assessed at the age of 5 years. The 5 year old cohort assessed significantly better on behavioral and cognitive performance and significantly worse on motor performance but still in the normal range compared with the theoretic distribution in the general population. Four children (3.8% of the 5 year old cohort had developmental problems/delays. Two of them were previously diagnosed with a form of autism (pervasive developmental disorder not otherwise specified) Two children had developmental problems based on our behavioral, cognitive, and/or motor assessments. CONCLUSION(S) The long term effects on development and health in children born after TESE ICSI procedures seem to be reassuring.
Fertility and sterility