A Case of Unicentric Castleman Disease and Langerhans Cell Histiocytosis: Two Entities in One Lymph Node
<i>Background:</i> Castleman disease (CD) is a lymphoproliferative disorder and Langerhans cell histiocytosis (LCH) is a clonal disease of the monocyte-macrophage system. The authors describe a rare case of CD coexistent with LCH at diagnosis in one lymph node. <i>Methods:</i> Hematologic investigation and intrapulmonary mass biopsy were performed. <i>Results:</i> The patient achieved complete remission and, up to now, no signs of recurrence were found. <i>Conclusions:</i> The report about co-existence with CD and LCH will promote correct diagnosis because of the recognition of this rare morphologic combination. An adequate amount of tissue should be obtained to avoid missing the diagnosis.