Primary ciliary dyskinesia and humoral immunodeficiency--is there a missing link?
Primary ciliary dyskinesia (PCD) and humoral mmunodeficiency (HID) are both rare disorders which cause recurrent upper and lower respiratory tract infections. To examine the concurrence of PCD and HID in a patient cohort with known PCD. Retrospective review of the patient files. We describe 11 patients of a cohort of 168 patients with PCD (6.5%) with a combination of PCD and some form of HID. The patients all presented with typical clinical symptoms for PCD, however the role of the concomitant immunological abnormalities is not clear. PCD and HID coincided in 6.5% of the patients. We suggest that a common pathophysiological pathway results in both disorders.