Combination Treatment of High‐Dose Pyridoxal Phosphate and Low‐Dose ACTH in Children with West Syndrome and Related Disorders
Abstract: Combination therapy of hih‐dose pyridoxal phosphate (PALP, 40–50 mg/kg/day) and low‐dose ACTIW1‐X‐Z (tetracosactide acetate‐Zn, Cortrosyn Z®, 0.01 mg/kg/day) was institnted in 26 children suffering from West syndrome and related disorders ‐pretreated without success with high‐dose PAL‐P alone; 18 with West syndrome (14 with symptomatic and 4 with cryptogenic types), 2 with symptomatic Lennox‐Gastaut syndrome, 5 with cerebral palsy with hypsarhythmia or diffuse slow spike‐waves and one with myoclonic seizures (secondary generalized epilepsy). Clinical, electroencephalographic and neurochemical investigations were carried out.