To the optimization of the diagnosis of primary ciliary dyskinesia
Functional and morphological studies of the mucociliary system in primary ciliary dyskinesia were conducted using a model of the Zivert-Cartagener syndrome. They established the specific features of the mucociliary system and the expediency of a direct evaluation of mucociliary clearance by a non-invasive method in vivo, by taking into account the pronounced degree of mucociliary insufficiency. This makes it possible, no matter whether the situs inversus is absent or present, to reduce a cumbersome diagnostic complex usually used to verify this pathology and to undertake a study of the ultrastructure of bronchial epithelial cilia immediately. This approach enhances the accuracy of a diagnosis of this pathology, decreases its scope and time, and reduces its cost.