Persistent hyperinsulinemic neonatal hypoglycemia caused by focal nesidioblastosis
Preoperative diagnosis by pancreatic venous sampling. A female infant with persistent hyperinsulinemic hypoglycemia is described. Persistent euglycemia could not be achieved by diazoxide, somatostatin and frequent, low protein feeds. Preoperative localization of focal insulin hypersecretion by percutaneous pancreatic venous sampling allowed excision of only a small pancreatic portion which was followed by normalization of blood glucose levels.