Castleman's disease in a patient with recurrent reactive lymphadenopathy
Castleman's disease is an uncommon benign disorder associated with progressive lymph node enlargement. It most commonly involves the mediastinum and involvement of the neck accounts for 6%. A 28-year-old male presented with a progressively enlarging left-sided neck mass. He had a history of excisional lymph node biopsy that yielded a histopathologic diagnosis of reactive lymphadenopathy. In our clinic, a repeat excisional biopsy was performed and the diagnosis was made as Castleman's disease. Although it is an uncommon cause of lymphadenopathy in the neck, Castleman's disease should be considered in the differential diagnosis of recurring lymphadenopathies. Repeated excisional biopsies may be necessary (from the largest lymph node when possible) to uncover the disease.