NMR spectroscopic analysis of 2-mercapto-5-methyl-1,3,4-thiadiazole in cefazolin.
A rapid, sensitive, and accurate method for the quantitative analysis of 2-mercapto-5-methyl-1,3,4-thiadiazole in cefazolin is presented. The method utilizes NMR spectroscopy and is based on the difference in the chemical shift of the methyl protons on free thiadiazole and the thiadiazole moiety of cefazolin.
Analysis of cacodylate injections by NMR spectroscopy.
An NMR procedure was developed for the assay of sodium cacodylate injection. The results obtained by this technique compare favorably with those obtained by the NF X method and atomic absorption spectrophotometry. The advantages of the NMR procedure over the other procedures are that it is highly specific for the cacodylate and that it is less time consuming.
Simultaneous determination of trimethadione and its metabolite, dimethadione, by gas-liquid chromatography.
A simple gas chromatographic procedure is described for the measurement of trimethadione and its major metabolite, dimethadione, in serum. The method, with which compounds can be determined on a single extraction and injection, is reliable and free from interference caused by other drugs, particularly those that the patient is likely to be taking in combination with trimethadione.