06 05 49 3 v 1 19 M ay 2 00 6 A New Mechanism for Gravitational Wave Emission in Core-Collapse Supernovae
Christian D. Ott, Adam Burrows, Luc Dessart, Eli Livne Max-Planck-Institut für Gravitationsphysik, Albert-Einstein-Institut, Potsdam, Germany; cott@aei.mpg.de Department of Astronomy and Steward Observatory, The University of Arizona, Tucson, AZ 85721; burrows@zenith.as.arizona.edu,luc@as.arizona.edu and Racah Institute of Physics, The Hebrew University, Jerusalem, Israel; eli@frodo.fiz.huji.ac.il
PROCEEDINGS OF THE Britbsh Pharmacoloqical The antihypertensive properties and effects on urate and electrolyte excretion of tienilic acid, bendrofluazide and spironolactone Influence of coronary artery occlusion on tthe myocardial distribution of digoxin
Speculation continues as to whether or not digoxin enhances the risk of ventricular dysrhythmias during acute myocardial infarction (Lown, Klein, Barr, Hagemeyer, Kosowsky & Garrison, 1972). Any heterogeneous distribution of digoxin might increase the arrhythmogenic potential of the ischaemic myocardium. Two aspects of the relationship between ischaemia of the myocardium and myocardial digoxin concentrations were therefore studied in 28 open-chest dogs with anterior wall infarction; firstly myocardial digoxin uptake and secondly, but more importantly, the rate and duration of the 'washout' of the drug from the myocardium. The uptake of 1251 labelled digoxin by the ischaemic myocardium, although directly proportional to regional myocardial blood flow (RMBF), was less severely depressed than was RMBF. As 'washout' times during continuing coronary occlusion were prolonged for up to 12 h, the concentrations of 1251 labelled digoxin in the ischaemic myocardium became steadily higher relative to those in the normal myocardium and reaching up to 208% of the normal. In addition, the more ischaemic the myocardium, the slower was the 'washout'. Thus, in acute myocardial infarction the distribution of digoxin throughout the myocardium is markedly heterogeneous and the effects of continued administration of the drug merit further study.
The Impact of EU Unfair Contract Terms Law on U.S. Business-to-Consumer Internet Merchants
When the Court of Appeals for Versailles issued its decision in AOL France v. UFC Que Choisir2 in September 2005, it sent the message to U.S. Internet businesses that even contractual boilerplate localized for European markets may be invalid in European consumer transactions. In that case, a French consumer advocacy group challenged the terms AOL offered its French customers after AOL had made extensive revisions to its standard form contracts to respond to the concerns regarding those terms expressed in an advisory opinion by a French consumer protection agency. In 2004, a trial court invalidated nearly every term in the revised agreement; the appeals court affirmed on all counts. Subsequently, in July 2006 following concerns raised by the Office of Fair Trading (“OFT”), a United Kingdom government agency charged with “making sure markets work well for consumers,”3 Dell Corporation Limited changed its online terms and conditions to make them fairer to consumers.4 European consumer contract law had an impact in both cases. At issue for AOL France and Dell Corporation Limited was the application of France’s and the UK’s consumer contract law which is based on the Unfair Contract Terms Directive of 19945 and calls into question the validity of many of the terms that U.S. courts routinely enforce in transactions involving American consumers and merchants.