Remarkable effect of nitrogen dioxide for N-hydroxyphthalimide-catalyzed aerobic oxidation of methylquinolines.
Aerobic oxidation of methylquinolines was successfully achieved by the use of N-hydroxyphthalimide/Co(OAc)2/Mn(OAc)2 as catalyst in the presence of a small amount of nitrogen dioxide as an initiator.
Co/NHPI-mediated aerobic oxygenation of benzylic C–H bonds in pharmaceutically relevant molecules† †Electronic supplementary information (ESI) available: Screening data, experimental protocols, characterization data. See DOI: 10.1039/c6sc03831j Click here for additional data file.
A new method for Co/NHPI-catalyzed aerobic C–H oxygenation shows excellent tolerance of electronically diverse heterocycles.
THE FRIEDEL-CRAFTS REACTION OF THE BAYLIS-HILLMAN ADDUCTS
A simple and convenient methodology for the stereoselective construction of 2-benzyl substituted trisubstituted olefins via sulfuric acid catalyzed Fredel-Crafts reaction of benzene with Baylis-Hillman adducts is described.