Aerosol recovery from large-volume reservoir delivery systems is highly dependent on the static properties of the reservoir
In this study, the role of electrostatic fields on aerosol recovery from a system with a large collapsible reservoir (30 L) was investigated. In addition, the efficacy of the reservoir method for bronchial challenge procedures was assessed in vivo. Aerosol recovery was determined by measuring the fraction of aerosol (0.05% 99mTc-tagged human albumin solution) retrieved from the reservoir. Before aerosol recovery experiments, electrostatic fields in the reservoir were measured. Aerosol recovery varied significantly with wall thickness of the reservoir and presence of an antistatic coating (range 6.0-70.3%). A close inverse relationship was found between the mean electrostatic field in the reservoir and aerosol recovery. The nebulized provocative concentration of histamine causing a 20% fall in forced expiratory volume in one second in asthmatics was found to be approximately half that of a standard method when compared with the reservoir system (mean ratio 2.24 (95% confidence interval, 1.60-3.12)). Recovery from an aerosol delivery system with a relatively large collapsible aerosol reservoir was highly dependent on the electrostatic field in the reservoir. In these systems the use of electrostatic field dissipative material for the reservoir is therefore recommended.
UvA-DARE ( Digital Academic Repository ) Allergic asthma : Environmental factors challenging the immune system
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The microscale obstacle-resolving meteorological model MITRAS v2.0: model theory
Abstract. This paper describes the developing theory and underlying
processes of the microscale obstacle-resolving model MITRAS version 2. MITRAS
calculates wind, temperature, humidity, and precipitation fields, as well as
transport within the obstacle layer using Reynolds averaging. It explicitly
resolves obstacles, including buildings and overhanging obstacles, to
consider their aerodynamic and thermodynamic effects. Buildings are
represented by impermeable grid cells at the building positions so that the
wind speed vanishes in these grid cells. Wall functions are used to calculate
appropriate turbulent fluxes. Most exchange processes at the obstacle
surfaces are considered in MITRAS, including turbulent and radiative
processes, in order to obtain an accurate surface temperature. MITRAS is also
able to simulate the effect of wind turbines. They are parameterized using
the actuator-disk concept to account for the reduction in wind speed. The
turbulence generation in the wake of a wind turbine is parameterized by
adding an additional part to the turbulence mechanical production term in the
turbulent kinetic energy equation. Effects of trees are considered
explicitly, including the wind speed reduction, turbulence production, and
dissipation due to drag forces from plant foliage elements, as well as the
radiation absorption and shading. The paper provides not only
documentation of the model dynamics and numerical framework but also a solid
foundation for future microscale model extensions.
