Structure and configuration of tavimolidin
From the roots ofPeucedanum mogoltavicum Korov. have been isolated tadzhiferin, farnesiferol B, 5-methoxy-3,4-methylenedioxypropiophenone, and a new terpenoid coumarin — tavimolidin. The structure and absolute configuration of tavimolidin have been established on the basis of a study of its chemical and spectral characteristics. The passage from tavimolidin to feselol has confirmed the structure proposed previously for mogoltavinin, mogoltavin, and mogoltin and has established their absolute configurations.
A new coumarin from Ferula loscosii and the correct structure of coladonin
Abstract From the roots of Ferula loscosii the coumarins umbelliprenin, coladin and coladonin and the new natural isovaleryl derivative of the latter have been isolated. A study which confirms the structure of coladonin and its difference from farnesiferol A is also given.
Thorium-induced Anatomical and Histopathological Changes in Liver of Swiss Mice
ObjectivePresent study is aimed to investigate the anatomical and histopathological changes in liver tissues of Swiss albino male mice, one month after intravenous administration of thorium (232Th; 4 and 40 mg/kg).MethodsSynchrotron X-ray micro-CT imaging, CD31 immuno-cytochemistry, hematoxylin & eosin staining and Periodic acid-Schiff staining were performed to study changes in liver anatomy, blood vessels/capillaries, histology and glycogen content of liver, respectively.ResultsSynchrotron X-ray micro-CT imaging of liver showed loss of blood vessels in mice treated with thorium (4 mg/kg), which was more prominent at higher dose of thorium (40 mg/kg). These thorium-induced changes in liver were correlated with the decrease in CD31 positive cells and loss of tissue architecture. A dose-dependent increase in glycogen content was also observed in the liver of thorium-treated mice.ConclusionOur results provide novel insight about the effects of thorium on liver, which may have significant implications in understanding the mechanism of thorium thorium-induced hepatotoxicity.