Illuminated Physiology and Medical Uses of Light
ABSTRACT The purpose of this paper is to bring a broader understanding to the physiology of light metabolism in the human body and to present novel techniques of utilizing light diagnostically and therapeutically. Much work has been done to use light to achieve altered states of consciousness, and there is much research documenting the presence and activities of light within the body. However, this paper seeks to promote the utilization of light as a primary treatment. A brief explanation of the author's novel diagnostic technique, BioResonance Scanning™, and novel treatment technique called NeuroPhotonic TherapyTM is detailed with clinical gems and case review
Microtube theory of sensory transduction.
Abstract It is proposed that ciliary microtubules are actively involved in the reception and transduction of sensory information from the distal portion of the dendrite to the basal body area of the receptor cell. Environmental stimuli may cause stimulus-specific conformational changes in the tubulin protein molecule. This characteristic change may then be propagated along the tubulin polymer filaments. Once this coded information has reached the cell body, classical ion flux mechanisms are thought to further amplify the stimulus energy and transmit its patterned information (generator potential) to the action potential generating sites of the cell. Morphological and biochemical evidence for this point of view is presented.
Gene control in eukaryotes and thec-value paradox “Excess” DNA as an impediment to transcription of coding sequences
SummaryWays in which control of gene activity may lead to the observed high DNA content per haploid eukaryote genome are examined. It is proposed that deoxyribonucleoprotein (DNP) acts as a barrier to transcription at two distinct structural levels.At the lower level, melting of the nucleosome supercoil (quaternary structure) and of the nucleosomes (tertiary structure) might be brought about by the process of transcription itself. After unwinding the barrier section, the polymerase would eventually reach the structural gene. The transcripts of noncoding sequences, at least as far as their “unique” sequence components are concerned, may thus have filled their main function through the very process of transcription. The possibility of an inverse relationship between the length of the DNP barrier and the rates of transcription of the coding sequences is to some extent supported by available data. Different modes of coordination between the transcription of mRNA and of hnRNA from a single functional unit of gene action (fuga) are considered.An analysis of gene control at high structural levels of DNP is made on the basis of other data, in relation to the concepts of eurygenic and stenogenic control. The concept of a euryon is introduced, namely of a set of linked fugas under common eurygenic control. Structure of order higher than quaternary can be inferred to exist in larger chromomeres of polytene chromosomes and in corresponding sections of ordinary chromosomes. Only moderate amounts of highest order interphase euchromatic structure are likely to be able to be accomodated in average chromomeres and none in very thin chromomeres. Puffs are interpreted as the melting of highest order interphase structure, and the absence of puffs during transcription as the absence of this highest order structure in the resting state of the chromomeres. Genes that are constantly active in all tissues may dispense with highest order interphase structure and with the corresponding control mechanism, and the fugas involved thus may not puff. Puffs, large chromomeres and highest order interphase euchromatic DNP structure seem to be correlated with genes that need to be transcribed only under certain developmental conditions. It is proposed that the function of high order structure is to sequester genetic material, namely mainly controller sequences. Since such high order structure, in most cases, would be built up to house the controller dependencies of justone structural gene, the amount of DNA per structural gene needed for gene control would be considerable, and the concept, if correct, would go a long way towards explaining thec-value paradox (“excess” DNA in eukaryotes).In eurygenic determination, the high order structure is thought to be conditioned for melting or to actually melt to an intermediate level of structure. From there, stenogenic control, leading to transcription, is considered to carry the melting process further to yet lower structural levels.Middle repetitive sequences, inasmuch as they represent receptor sequences for eurygenic control, are hypothesized to be associated with interbands. Structural genes are probably mostly located at the edge of a band and, under certain conditions, are allowed to extend into interbands. Receptor sequences relevant to the activation and repression of individual genes (stenogenic control sites) are thought to be likely to be located within bands, if the barrier concept is valid.