Large-area Si(Li) orthogonal-strip detectors
Segmented lithium drifted silicon detectors are being developed for use in large Compton cameras and for medical imaging. We have successfully fabricated 3.5 mm thick crossed-strip detectors with active areas of 40 /spl times/ 40 mm/sup 2/ with a 2 mm strip pitch. These detectors utilize new contact technology consisting of a boron implanted p-type contact and an amorphous silicon (/spl alpha/-Si) n-type contact. Good energy resolution and excellent strip separation was obtained from both contacts at relatively high operating temperatures. An energy resolution of 2.1 keV FWHM at 122 keV was obtained for the /spl alpha/-Si strip at temperature up to 200 K and for the B strip at temperature up to 240 K. Measurements of the charge sharing between the strips were also performed. When the detector was flood illuminated with 60 keV gamma-rays, a small signal deficit was observed for events in which the signal was shared between two adjacent strips. The amount of deficit depended on the contact type, strip geometry and the operating temperature.
Large-volume Si(Li) orthogonal-strip detectors for Compton-effect-based instruments
Recent developments of large-area Si(Li) orthogonal-strip detectors have revealed their capability for applications in Compton-effect-based instruments. Some inherent advantages of silicon such as the dominance of Compton scattering in photon interactions and operation at room or somewhat lower temperature combined with the availability of large-volume Si(Li) detectors could stimulate the development of powerful Compton instruments. Several diodes 10 mm in thickness with a diameter of 102 mm were fabricated. Two 10 mm thick diodes were cut to form a 74 mmtimes74 mm square with slightly rounded corners. The same position-sensitive structure, 32 strips with a pitch of 2 mm, was produced on the thin Li-diffused n-contact and boron-implanted p+-contact by means of photolithography and plasma etched grooves. The position-sensitive area of 64 mmtimes64 mm is surrounded by a 5 mm wide guard-ring. One of these 10 mm thick Si(Li) orthogonal-strip detectors has been mounted in a cryostat prepared at Lawrence Livermore National Laboratory (LLNL). The detector will be extensively tested there with the goal of being integrated into the Compact Si+Ge Compton camera system consisting of this Si(Li) and a HPGe orthogonal-strip detector
Thorium-induced Anatomical and Histopathological Changes in Liver of Swiss Mice
ObjectivePresent study is aimed to investigate the anatomical and histopathological changes in liver tissues of Swiss albino male mice, one month after intravenous administration of thorium (232Th; 4 and 40 mg/kg).MethodsSynchrotron X-ray micro-CT imaging, CD31 immuno-cytochemistry, hematoxylin & eosin staining and Periodic acid-Schiff staining were performed to study changes in liver anatomy, blood vessels/capillaries, histology and glycogen content of liver, respectively.ResultsSynchrotron X-ray micro-CT imaging of liver showed loss of blood vessels in mice treated with thorium (4 mg/kg), which was more prominent at higher dose of thorium (40 mg/kg). These thorium-induced changes in liver were correlated with the decrease in CD31 positive cells and loss of tissue architecture. A dose-dependent increase in glycogen content was also observed in the liver of thorium-treated mice.ConclusionOur results provide novel insight about the effects of thorium on liver, which may have significant implications in understanding the mechanism of thorium thorium-induced hepatotoxicity.