Impact of Excessive Stocks in Process of Bearing Stock Optimization Using Branch and Bound Method
Supply process is one of major priorities for each manufacturing plant. To produce quality products with low prices is an advantage in competition on the market. A prerequisite for such a state is to minimize prices of production inputs, which can be achieved by stock optimizing. Presented contribution on specific example illustrates discrete optimization process on principles of Branch & Bound, which defines the input, and optimized parameters of initial stock of bearings in selected companies operating on Slovak market. In conclusion, the impact of optimized solutions is given and highlights the need for optimization.
Laserowe modyfikowanie materiałów polimerowych. Cz. I. Fizyczne podstawy działania i kryteria doboru laserów
On the basis of literature review the fundamentals of lasers' operation were discussed (Fig. 1 and 2). The general classification of lasers (Table 3, Fig. 3) and the principles of action of two-, three- and four-level lasers (Fig. 4 and 5) were presented. Selected phenomena going in the materials as the results of laser irradiation were described, among others linear and non-linear absorption. The significance of absorption coefficient and laser light reflection coefficient in the processes of modifications of surface layers (WW) of polymeric materials has been stressed (Table 1, Fig. 6). Basic criteria of selection of lasers suitable for this application were given. Possibilities and limitations of lasers in modification of polymeric materials' surface layers have been marked.
Modulating dopamine receptors subtype selectivity by thiophene and benzothiophene based derivatives
In this work we tried to develop new dopaminergic ligands with novel affinity and selectivity profile towards the five different dopamine receptor subtypes; namely D1, D2, D3, D4, and D5 receptors to come up with new medical agents but with fewer side effects relative to those present in the medicinal market such as Haloperidol that is considered to be among the very famous typical antipsychotic agents characterized with Extrapyramidal symptoms adverse effects and Clozapine that represents the atypical antipsychotic agents that suffers agranulocytosis adverse effects. Among the fifty five synthesized ligands, compounds 3, 44a, and 45a were shown to have unique subtype receptor selectivity, thus could be promising atypical antipsychotic agents. Compound 3 was the first azecine derivative to show antagonistic action on both D2 and D5 receptor subtypes, (Ki (D2): 1.5 nM; Ki (D5): 1.9 nM). Compound 44a showed to be more than 200 times more selective to D2 receptors rather than D4 (Ki (D2): 138 nM; Ki (D4):0.62 nM). Compound 45a has shown to be more than 100 times more selective to D3 rather than D2 receptor subtypes and more than 900 times more selective to D4 rather than D2 receptor subtypes (Ki (D2): 28.5 nM; Ki (D3): 0.26 nM; Ki (D4): 0.03 nM).