Microbiological Evaluation of 4-substituted-imidazolidine Derivatives
In the present studies, two series of 4-substituted-imidazolidines (IIIa-i and IIIj,k) were synthesized by reacting different tetrahydro-di-Schiff bases (IIa-i and IIj,k) with p-diethylaminobenzaldehyde/ dimethylaminobenzaldehyde. The title compounds were evaluated for their antibacterial and antifungal actions against some selected microbes. The results of microbiological evaluation revealed that two compounds, 4-(1,3-bis(benzo[d][1,3]dioxol-5-ylmethyl)-4-methylimidazolidin-2-yl)-N,N-diethyl aniline (IIIj), 4-(1,3-bis(benzo[d][1,3]dioxol-5-ylmethyl)-4-methylimidazolidin-2-yl)-N,N-dimethyl aniline (IIIk) were good in their antibacterial as well as antifungal actions. Minimum inhibitory concentration values (MIC) of the compounds are reported.
Synthesis and biological screening of di- and trisubstituted imidazoles.
Disubstituted imidazoles were prepared by reacting appropriate phenylglyoxal with different aryl aldehydes in the presence of ammonium acetate. Trisubstituted imidazoles were prepared by reacting disubstituted imidazoles with chlorobenzene in the presence of catalytic amount of triethylamine (TEA). The synthesized compounds were characterized on the basis of IR, 1H-NMR and mass spectral data and elemental analysis results. They were tested for their antiinflammatory and antimicrobial actions. Two compounds showed good antiinflammatory activity in carrageenan induced rat paw edema test with very low ulcerogenic activity. Fair number of compounds were found to have significant antimicrobial activity especially against fungal species.
A resposta do Schistosoma mansoni mantido in vitro frente a derivados imidazolidinonicos
Silvânia M. OLIVEIRA 1, Mônica C.P.A. ALBUQUERQUE 2, Maira G.R. PITTA 3, Elisabeth MALAGUEÑO 3,4, José V. SANTANA 3,5, Maria do Carmo A. LIMA 1, Ivan R. PITTA 1 & Suely L. GALDINO 1* 1 Departamento de Antibióticos, 2 Departamento de Medicina Tropical, 3 Laboratório de Imunopatologia Keizo Asami, 4 Departamento de Ciências Farmacêuticas, 5 Departamento de Biofísica. Universidade Federal de Pernambuco. 50670-901. Recife, PE