Chloroperoxidase-catalyzed oxidation of N-methyl-4-chloroaniline
Chloroperoxidase catalyzed the H2O2 oxidative conversion of N-methyl-4-chloroaniline to 4-chloronitrosobenzene, 4-chloroaniline and a mixture of complex products.
Studies in peroxidase action—XX
Abstract The peroxidase catalysed oxidation of a mixture of p-toluidine and 4-chloroaniline gives rise to a large number of products. The major products, aminoanilinobenzoquinone dianils, are all derived from N-p-tolylbenzoquinone diimine. Perkin bases derived from 4,4′-dimethyldiphenylamine, azobenzenes and azophenines are also produced. The mechanism of the formation of the products is discussed.
Fungal Biotransformations in Pharmaceutical Sciences
The regio- and stereoselective conversion of complex substrates represents one of the major advantage of microbial biotransformation. This chapter covers the biocatalytic capacities of fungi to derivatize bioactive small molecules, both from natural sources and from synthetic compounds. We focus particularly on sterol and taxane biotransformation. We also present examples at the interface of biotransformation and pathway engineering using recombinant organisms, with an emphasis on the production of lovastatin derivatives. Finally, we highlight selected studies on fungal xenometabolism which serves as a model to study the breakdown of drugs in mammals.