Assessment of high strength and light weight aggregate concrete properties using ultrasonic pulse velocity technique
In this study, the ultrasonic pulse velocity technique as a non-destructive testing of concrete was used to assess the effect of some criteria on high strength and light weight aggregate concrete. The study included several concrete mix design with ages of 7, 28 and 90 days. The effect of age, cement content, water ratio and slump on two concrete types was studied and discussed. The use of ultrasonic pulse velocity technique to assessconcrete strength and quality was a good choice for effects determination. 
 
   
 
 Key words: Non destructive testing (NDT), ultrasonic pulse velocity (UPV), compressive strength, regression analysis.
Application of hybrid learning algorithm for optimization of LED lens design
In this study was performed optimization procedure of LED lens design by adaptive neuro fuzzy inference system (ANFIS). There are two objective functions in the optimization procedure: viewing angle and luminance uniformity. Optical design software was used for experimental procedure in order to extract training data for the ANFIS optimization procedure. In the first step of the optimization procedure the viewing angle was used as the optimization objective function. Afterwards the initial optimization of the lens shape was found. In the next step the luminance uniformity was used as the second optimization objective function. ANFIS model was used to find the optimal parameters for the LED lens design. The optimal parameters were found based on minimization of the ANFIS prediction accuracy of the viewing angle and luminance uniformity. The selected optimal parameters could be used further for improvement of the LED lens design.
An injectable and thermosensitive hydrogel: Promoting periodontal regeneration by controlled-release of aspirin and erythropoietin.
Periodontitis is an inflammatory disease induced by complex interactions between host immune system and plaque microorganism. Alveolar bone resorption caused by periodontitis is considered to be one of the main reasons for tooth loss in adults. To terminate the alveolar bone resorption, simultaneous anti-inflammation and periodontium regeneration is required, which has not appeared in the existing methods. In this study, chitosan (CS), β-sodium glycerophosphate (β-GP), and gelatin were used to prepare an injectable and thermosensitive hydrogel, which could continuously release aspirin and erythropoietin (EPO) to exert pharmacological effects of anti-inflammation and tissue regeneration, respectively. The releasing profile showed that aspirin and EPO could be continuously released from the hydrogels, which exhibited no toxicity both in vitro and in vivo, for at least 21 days. Immunohistochemistry staining and micro-CT analyses indicated that administration of CS/β-GP/gelatin hydrogels loaded with aspirin/EPO could terminate the inflammation and recover the height of the alveolar bone, which is further confirmed by histological observations. Our results suggested that CS/β-GP/gelatin hydrogels are easily prepared as drug-loading vectors with excellent biocompatibility, and the CS/β-GP/gelatin hydrogels loaded with aspirin/EPO are quite effective in anti-inflammation and periodontium regeneration, which provides a great potential candidate for periodontitis treatment in the dental clinic. Statement of Significance To terminate the alveolar bone resorption caused by periodontitis, simultaneous anti-inflammation and periodontium regeneration is required, which has not appeared in the existing methods. Here, (1) the chitosan (CS)/β-sodium glycerophosphate/gelatin hydrogels loaded with aspirin/erythropoietin (EPO) can form at body temperature in 5 min with excellent biocompatibility in vitro and in vivo; (2) The faster release of aspirin than EPO in the early stage is beneficial for anti-inflammation and provides a microenvironment for ensuring the regeneration function of EPO in the following step. In vivo experiments revealed that the hydrogels are effective in the control of inflammation and regeneration of the periodontium. These results indicate that our synthesized hydrogels have a great potential in the future clinical application.