Samuel Putnam, cosmopolitismo y vanguardia española en Estados Unidos
This article explores the early reception of the Spanish avant-garde in the United States through the analysis of the work of the American literary critic Samuel Putnam (1888-1950), and frames his output as part of a new form of cosmopolitan criticism in fashion during the twenties. From his position as an expatriate in Paris, Putnam’s work as translator, reviewer, and editor made him a promoter and a publicist of the European avant-gardes, and he paid close attention to the writings of Alberti, Giménez Caballero and Jarnés. The article documents the vision that Putnam offered of the most innovative Spanish literature and explains how his critical position was modified when he returned to the States in the thirties and advocated greater involvement of writers in politics.
Becoming Americans in Paris : transatlantic politics and culture between the World Wars
Introduction: The Age of World Wars Part I: The Specter of Americanization 1. Triumphant Arrivals 2. Reluctant Hosts Part II: Parisian Cultural Politics 3. The Sacco-Vanzetti Riots 4. Prefect Chiappe's Purging of Paris Part III: American Political Culture 5. Legionnaires on Parade 6. The Expatriates Reconsidered Epilogue: The Beginning of American Innocence Notes Bibliography Index
Pharmacokinetics and Metabolism of 14C-Brivaracetam, a Novel SV2A Ligand, in Healthy Subjects
This study was designed to investigate the human absorption, disposition, and mass balance of 14C-brivaracetam, a novel high affinity SV2A ligand with potent anticonvulsant activity. Six healthy male subjects received a single p.o. dose of 14C-brivaracetam (150 mg, 82 μCi, or 3.03 MBq). Serial blood and complete urine and feces were collected until 144 h postdose. Expired air samples were obtained until 24 h. Brivaracetam was rapidly absorbed, with Cmax of 4 μg/ml occurring within 1.5 h of dosing. Unchanged brivaracetam amounted to 90% of the total plasma radioactivity, suggesting a modest first-pass effect. Plasma protein binding of radioactivity was low (17.5%). Urinary excretion exceeded 90% after 2 days, and the final mass balance reached 96.8% of the radioactivity in urine and 0.7% in feces. Only 8.6% of the radioactive dose was recovered in urine as unchanged brivaracetam, the remainder being identified as non–cytochrome P450 (P450)- and P450-dependent biotransformation products resulting from hydrolysis of the amide moiety (M9, 34.2%), hydroxylation of the n-propyl side chain (M1b, 15.9%), and a combination of these two pathways leading to the hydroxy acid (M4b, 15.2%). Minor amounts of taurine and glucuronic acid conjugates and other oxidized derivatives were also identified. Brivaracetam is completely absorbed, is weakly bound to plasma proteins, extensively biotransformed through several metabolic pathways, and eliminated renally.