06 05 49 3 v 1 19 M ay 2 00 6 A New Mechanism for Gravitational Wave Emission in Core-Collapse Supernovae
Christian D. Ott, Adam Burrows, Luc Dessart, Eli Livne Max-Planck-Institut für Gravitationsphysik, Albert-Einstein-Institut, Potsdam, Germany; cott@aei.mpg.de Department of Astronomy and Steward Observatory, The University of Arizona, Tucson, AZ 85721; burrows@zenith.as.arizona.edu,luc@as.arizona.edu and Racah Institute of Physics, The Hebrew University, Jerusalem, Israel; eli@frodo.fiz.huji.ac.il
PROCEEDINGS OF THE Britbsh Pharmacoloqical The antihypertensive properties and effects on urate and electrolyte excretion of tienilic acid, bendrofluazide and spironolactone Influence of coronary artery occlusion on tthe myocardial distribution of digoxin
Speculation continues as to whether or not digoxin enhances the risk of ventricular dysrhythmias during acute myocardial infarction (Lown, Klein, Barr, Hagemeyer, Kosowsky & Garrison, 1972). Any heterogeneous distribution of digoxin might increase the arrhythmogenic potential of the ischaemic myocardium. Two aspects of the relationship between ischaemia of the myocardium and myocardial digoxin concentrations were therefore studied in 28 open-chest dogs with anterior wall infarction; firstly myocardial digoxin uptake and secondly, but more importantly, the rate and duration of the 'washout' of the drug from the myocardium. The uptake of 1251 labelled digoxin by the ischaemic myocardium, although directly proportional to regional myocardial blood flow (RMBF), was less severely depressed than was RMBF. As 'washout' times during continuing coronary occlusion were prolonged for up to 12 h, the concentrations of 1251 labelled digoxin in the ischaemic myocardium became steadily higher relative to those in the normal myocardium and reaching up to 208% of the normal. In addition, the more ischaemic the myocardium, the slower was the 'washout'. Thus, in acute myocardial infarction the distribution of digoxin throughout the myocardium is markedly heterogeneous and the effects of continued administration of the drug merit further study.
Sensitivity to digitalis drugs in acute myocardial infarction.
Abstract Tolerance for digitalis during acute myocardial infarction was evaluated by acetyl strophanthidin testing. Fifty-four patients hospitalized in a coronary care unit were studied within 48 hours of admission; continuous electrocardiographic monitoring and the rapid onset in activity of acetyl strophanthidin allowed a precise titration of druginduced arrhythmias. The dose schedule was 0.1 to 0.2 mg every 5 to 6 minutes. Tolerance for 1.0 mg of acetyl strophanthidin or the emergence of gastrointestinal symptoms or electrocardiographic signs of early digitalis intoxication with 1.0 mg or less constituted the test procedure. Forty-eight of the patients (89 percent) tolerated a full dose of acetyl strophanthidin; ventricular ectopic mechanisms developed in only 3 patients (6.0 percent of those receiving 1.0 mg). An increase in blood pressure followed administration of acetyl strophanthidin in 32 (59.3 percent) of the 54 patients. These data suggest that the large majority of patients with acute myocardial infarction and heart failure can safely be treated with digitalis drugs.