Structure of the products of the metabolism of deoxypeganine and of deoxyvasicinone
The structures of the main components of the total metabolites of the anticholinesterase drug deoxypeganine (DOP) and its analog deoxyvasicinone (DOV) in the rat organism have been studied. The structures of two metabolites of DOP and DOV — 11α-hydroxydeoxyvasicinone and 2-(β-ethoxycarbonyl)ethyl-4-quinazoline — have been determined by the PMR method. On the basis of their structures and the results of measurements of the elementary compositions of ions, the fragmentation of the compounds has been elucidated. A minor component of the total metabolites has been isolated by chromato-mass spectrometry and for it the structure of 6-methoxydide-hydrovasicinone is proposed. A scheme of the metabolism of DOP and DOV has been put forward.
Bestimmung der Molekül‐ und Kristallstruktur sowie der Absolutkonfiguration von Peganin
Mittels Rontgenkristallstrukturanalyse wurde die Molekul- und Kristall-struktur sowie unter Ausnutzung der anomalen Streuung an den Chloratomen des Hydrochlorids von 2 die Absolutkonfiguration von (-)-Peganin 2 bestimmt. Danach besitzt 2R-Konfiguration. 
 
 
 
The Crystal and Molecular Structure of Peganine. Estimation of its Absolute Configuration 
 
 
 
The crystal and molecular structure of (-)-peganine hydrochloride 2 have been determined by X-ray structure analysis. Furthermore the absolute configuration of this alkaloid was deduced with the aid of the anomalous scattering at the Cl-atoms. The pyrrolidine ring of 2 has envelope conformation. 2 possesses R-configuration.
Heavy metal adsorption from industrial wastewater by PAMAM/TiO2 nanohybrid: Preparation, characterization and adsorption studies
Abstract This study investigates the removal of heavy metals from industrial wastewater using TiO 2 nanoparticles modified with poly-amidoamine dendrimer (PAMAM, G 4 ). The metal ions Cu 2 + , Pb 2 + , and Cd 2 + were selected as model pollutants. FTIR, SEM, BET surface area and Zeta potential measurements, and Dispersion Observing methods have been employed for characterizing the synthetic nanohybrid and these techniques indicated that the PAMAM loaded on to TiO 2 have been favorably synthesized. The effects of several parameters including initial metal ion concentration, temperature, pH solution, the nanohybrid dosage and contact time were studied. The experimental data were analyzed using equilibrium isotherm and kinetics models. The adsorption process was studied using isotherm, kinetics, and thermodynamics models. The analysis shows that the Langmuir isotherm and pseudo-second-order kinetics are appropriate models for the adsorption process. The thermodynamic parameters illustrate that the absorption is endothermic and spontaneous. The findings suggest that the nanohybrid is a good super absorbent for the removal of heavy metals from industrial effluents.