Antiviral activity of N-phosphorylated amides, thioamides, and their salts
The N-(O,O-dimethylphosphoryl)benzamide (I) was obtained according to [4]; N-(O-methylS-methylphosphoryl)acetamide (acephate) (II) was obtained according to [6], and N-(O,O-diisopropylthiophosphoryl)thiobenzamide (III) (benztriamiph) was obtained according to [7]. The synthesis of N-(O,O-diisopropylthiophosphoryl)thioacetamide (IV), the sodium salt of N-(O,O-dimethylphosphoryl)benzamide (V), and the sodium salt of N-(O,O-diethylphosphoryl)thiobenzamide (VI) is described below.
Synthesis and crystal structures of new potential chelating sulfonylamidophosphate ligands
Abstract Sulfonylamidophosphates with formula PhSO2NHP(O)(OR)2 (HL1: R = PhCH2 ; HL2: R = p-MeC6H4 ) and (p-C6H4SO2NHP(O)(OMe)2)2 (H2L3) were synthesized via a three-step procedure based on Kirsanov reaction. Sodium salts NaL1, NaL2 and Na2L3 were prepared from the corresponding sulfonylamidophosphates to explore their acid nature of the imide nitrogen. The products were characterized by means of 1H, 31P NMR and IR spectroscopies and elemental analysis. Crystal structures of HL2, H2L3 and NaL2 were determined using X-ray crystallography. HL2 produces a dimeric aggregate via intermolecular hydrogen bonding. In contrast, H2L3 and NaL2 form 1D polymeric chains.
Syntheses of a New Series of Transition Metal Chelates of Diphenylphosphinothioylthiourea Anion
New thiourea derivatives, 3-diphenylphosphinothioyl-1 -phenylthiourea (PTTU-A), 3-diphenylphosphinothioyl-1,1-diethyl thiourea (PTTU-B), and 3-diphenylphosphinothioyl-1,1-dimethylthiourea (PTTU-C) were found to behave as bidentate ligands with transition metal ions such as Ni(II), Pd(II), Co(II), and Cu(II) to give a series of novel metal chelates. The structures of these complexes are discussed on the basis of magnetic susceptibilities, infrared spectra, electronic spectra, powder X-ray diffraction patterns and elemental analyses. Tentative assignments of two metal-sulfur stretching vibrations in the far infrared spectra were made for Ni-PTTU and Pd-PTTU, which have square-planar configurations. However, the structures of the Cu-PTTU complexes could not be determined by these methods because of the instability of the complexes. They were confirmed by electronic and ESR spectroscopies.