Investigation of lactams
The recen t ly developed methods of synthesizing substi tuted 1H,2,3 ,4te t rahydroazepino[3,4-b] indoles [1-3] f rom cap ro l ac t am have opened broad pe r spec t ives for p repar ing condensed lndole de r iva t ives of biological in te res t [4]. In pa r t i cu la r , it became of in te res t to synthesize the indole analogs of such biological ly active compounds as Corazol ( a f t p e n t a m e t h y l e n e t e t r a z o l e ) [5], Omethy lcapro lac t im [6], and also a s e r i e s of 1,2and 10-subst i tu ted azepino[3,4b]indoles for pharmacologica l investigation.
Die Reaktion cyclischer Lactimäther mit Aminocarbonsäuren
Cyclische Lactimather reagieren mit aliphatischen und aromatischen, Aminocarbonsauren zunachst unter Bildung offenkettiger amidinartiger Verbindungen, die in der aliphatischen Reihe nur schwer zum Ring geschlossen werden konnen. Der Ringschlus vollzieht sich bei aromatischen und heterocyclischen o-Amino-carbonsauren sehr leicht. Die neue Synthese macht auch das Alkaloid Rutaecarpin (XV) leicht zuganglich.
The application of adsorptive stripping voltammetry for a study of the reaction of human serum albumin with anti-human serum albumin
Abstract Adsorptive stripping voltammetry has been used to study the interaction of human serum albumin with anti-human serum albumin. The adsorptive stripping voltammetric behaviour of both proteins has been optimised with respect to accumulation potential, accumulation time and scan rate. It has been demonstrated that adsorptive stripping voltammetry can be a useful technique for the study of the interaction of these two proteins directly in solution.