06 05 49 3 v 1 19 M ay 2 00 6 A New Mechanism for Gravitational Wave Emission in Core-Collapse Supernovae
Christian D. Ott, Adam Burrows, Luc Dessart, Eli Livne Max-Planck-Institut für Gravitationsphysik, Albert-Einstein-Institut, Potsdam, Germany; cott@aei.mpg.de Department of Astronomy and Steward Observatory, The University of Arizona, Tucson, AZ 85721; burrows@zenith.as.arizona.edu,luc@as.arizona.edu and Racah Institute of Physics, The Hebrew University, Jerusalem, Israel; eli@frodo.fiz.huji.ac.il
PROCEEDINGS OF THE Britbsh Pharmacoloqical The antihypertensive properties and effects on urate and electrolyte excretion of tienilic acid, bendrofluazide and spironolactone Influence of coronary artery occlusion on tthe myocardial distribution of digoxin
Speculation continues as to whether or not digoxin enhances the risk of ventricular dysrhythmias during acute myocardial infarction (Lown, Klein, Barr, Hagemeyer, Kosowsky & Garrison, 1972). Any heterogeneous distribution of digoxin might increase the arrhythmogenic potential of the ischaemic myocardium. Two aspects of the relationship between ischaemia of the myocardium and myocardial digoxin concentrations were therefore studied in 28 open-chest dogs with anterior wall infarction; firstly myocardial digoxin uptake and secondly, but more importantly, the rate and duration of the 'washout' of the drug from the myocardium. The uptake of 1251 labelled digoxin by the ischaemic myocardium, although directly proportional to regional myocardial blood flow (RMBF), was less severely depressed than was RMBF. As 'washout' times during continuing coronary occlusion were prolonged for up to 12 h, the concentrations of 1251 labelled digoxin in the ischaemic myocardium became steadily higher relative to those in the normal myocardium and reaching up to 208% of the normal. In addition, the more ischaemic the myocardium, the slower was the 'washout'. Thus, in acute myocardial infarction the distribution of digoxin throughout the myocardium is markedly heterogeneous and the effects of continued administration of the drug merit further study.
The MR-TOF-MS isobar separator for the TITAN facility at TRIUMF
At TRIUMF’s Ion Trap for Atomic and Nuclear Science (TITAN) a multiple-reflection time-of-flight mass spectrometer (MR-TOF-MS) will extend TITAN’s capabilities and facilitate mass measurements and in-trap decay spectroscopy of exotic nuclei that so far have not been possible due to strong isobaric contamination. This MR-TOF-MS will also enable mass measurements of very short-lived nuclides (half-life > 1 ms) that are produced in very low quantities (a few detected ions overall). In order to allow the installation of an MR-TOF-MS in the restricted space on the platform, on which the TITAN facility is located, novel mass spectrometric methods have been developed. Transport, cooling and distribution of the ions inside the device is done using a buffer gas-filled RFQ-based ion beam switchyard. Mass selection is achieved using a dynamic retrapping technique after time-of-flight analysis in an electrostatic isochronous reflector system. Only due to the combination of these novel methods the realization of an MR-TOF-MS based isobar separator at TITAN has become possible. The device has been built, commissioned off-line and is currently under installation at TITAN.