Gwent Reviews Its Needs
Gwent Education Authority systematically evaluates its policies, procedures, administration and the financial arrangements for young people with special educational needs. Julien Kramer, director of education, London Borough of Greenwich, until recently divisional director of education, School Support and Finance, Gwent, who has been working with service partners, the voluntary bodies and the district auditor, highlights strengths and weaknesses in service arrangements in Gwent and sets an agenda for change in anticipation of the requirements of the 1993 Education Act.
Restructuring Reform: choice and change in special education
Steve Rayner, Lecturer in Special Education in the School of Education at The University of Birmingham and formerly head of a residential school for pupils with emotional and behavioural difficulties, argues for a proactive response to educational reform in the management of special education. The action of choice and change is perceived as not only necessary for institutional survival but also as an opportunity for educational renewal and a revised definition of special educational need.
Target of inhibition by the anti-lipogenic antibiotic cerulenin of sterol synthesis in yeast.
Abstract The antibiotic cerulenin inhibited the incorporation of 14 C-acetyl-CoA by 67% at a concentration of 9 × 10 −6 M but not that of 14 C-HMG-CoA into the non-saponifiable fraction in a cell-free extract of Saccharomyces cerevisiae . Cerulenin markedly inhibited the activity of partially purified HMG-CoA synthase. No inhibition of acetoacetyl-CoA thiolase activity was observed in the same preparation of HMG-CoA synthase. Therefore, cerulenin inhibition of overall sterol synthesis may be accounted for by the specific inhibition of HMG-CoA synthase activity.