Mass spectrometry of some N-acyldaunosamine derivatives.
Abstract The principal modes of fragmentation subsequent to electron impact of some N -acyl derivatives of daunosamine, the glycoside moiety of the antitumour antibiotics daunomycin and adriamycin, have been studied by using specifically deuterated derivatives and high-resolution measurements. In particular, the elimination of MeOH from methyl β-daunosaminides is shown to occur extensively and stereo-specifically, and involves HO-4. The splitting of the moieties C-1-C-2 and C-5-O-5 affords the fragments D 2 , D ′ 2 , and D ′′ 2 , which are among the most abundant.
The synthesis of N-benzoyl-D-daunosamine
Abstract The structure of daunosamine (3-amino-2,3,6-trideoxy- L - lyxo -hexose), the carbohydrate component of the anti-tumour antibiotic daunomycin, has been confirmed by the synthesis of the N -benzoyl derivative of the D -enantiomorph from methyl 4,6- O -benzylidene-2-deoxy-α- D - ribo -hexopyranoside.
Regional strategies for the minerals industries of the states of the SADCC
The SADCC has been in existence for eleven years but little progress has been made in regional coordination of the minerals sector even though this sector is the most important exporter of the region. There is however scope for minerals development at the regional level.