Statistical optimisation applied to the spectrophotometric study of the tolmetin-Fe(III) complex.
Tolmetin sodium has been examined and determined from dosage forms as its Fe(III) complex and the method has been optimized by statistical optimization.
Stability-indicating assay for tolmetin sodium in solid dosage forms.
A spectrophotometric assay for determining tolmetin sodium in pharmaceutical solid dosage forms is described. Tolmetin sodium is separated from common pharmaceutical excipients and probable degradation products. Recovery, precision, and accuracy data are provided. Two TLC methods are included which can be used to monitor qualitatively the stability of aged dosage forms.
Clozapine derived 2,3-dihydro-1H-1,4- and 1,5-benzodiazepines with D4 receptor selectivity: synthesis and biological testing.
Novel 4-arylpiperazin-1-yl-substituted 2,3-dihydro-1H-1,4- and 1H-1,5-benzodiazepines and their aza-analogues were synthesized as debenzoclozapine derivatives for evaluation as potential D4-ligands. While Ki values of some of the title compounds came within the range of clozapine, they showed an impressively greater selectivity over other dopamine receptor subtypes, especially D2. For the most promising compounds, intrinsic activity and binding properties to serotonin 5-HT1A and 5-HT2 were also determined.