Stilbene derivatives from two species of Gnetaceae.
Five new stilbene oligomers (gnemonols A, B and C, gnemonoside E and gnetal) were isolated together with 2b-hydroxyampelopsin F and gnetin E from Gnetum gnemon and G. gnemonoides. The structures of the compounds were elucidated on the basis of spectral evidence.
Growth inhibition of stilbenoids in Welwitschiaceae and Gnetaceae through induction of apoptosis in human leukemia HL60 cells.
Fifty-six stilbenoids isolated from the families of Welwitschiaceae and Gnetaceae were screened for growth inhibitory activity against HL60 cells, and two compounds (gnemonol G and gnetin I) among them exhibited a strong activity with IC(50) of 10.0 microM and 12.2 microM at 48 h incubation, respectively. The growth suppression by gnemonol G and gnetin I was found to be in part due to apoptosis which was assessed by morphological findings such as nuclear condensation and fragmentation, and DNA ladder formation in human leukemia HL60 cells.
Canaliculatol, an antifungal resveratrol trimer from Stemonoporous canaliculatus
Abstract A new resveratrol trimer, canaliculatol, has been isolated from the bark of Stemonoporus canaliculatus . Canaliculatol showed antifungal activity against the fungus, Cladosporium cladosporioides. The structure and stereochemistry of canaliculatol is reported in this paper.