Noreudesmane sesquiterpenoids from the leaves of Nicotiana tabacum.
Six new 14-noreudesmane sesquiterpenoids, nicotabacosides A-F (1-6), along with five known sesquiterpenoids (7-11), were isolated from the leaves of Nicotiana tabacum. The structures of compounds 1-6 were elucidated as isorishitin 3-O-β-D-glucopyranoside (1), rishitin 3-O-β-D-glucopyranoside (2), rishitin 2-O-β-D-glucopyranoside (3), 1, 6-dehydro-rishitin 3-O-β-D-glucopyranoside (4), 2-hydroxyl-ligudentatol 3-O-β-D-glucopyranoside (5) and oxyglutinosone 3-O-β-D-glucopyranoside (6) based on extensive spectroscopic analyses (HRESIMS, UV, IR, 1D and 2D NMR). Their absolute configurations were determined by X-ray single-crystal diffraction and comparison of their electronic circular dichroism (ECD) spectra.
Lignans from the Fruits of Melia toosendan and Their Agonistic Activities on Melatonin Receptor MT1.
Investigation on the fruits of Melia toosendan afforded seven new lignans (1-7), along with seventeen known compounds (8-24). The structures of the new compounds, involving four neo-lignans (1-4), two sesquilignans (5-6), and a nor-lignan (7), were elucidated based on extensive spectroscopic analyses (high-resolution electrospray ionization mass spectra, ultraviolet, infrared, one-dimensional and two-dimensional nuclear magnetic resonance). Compound 24 exhibited activity on melatonin receptor type 1 with an agonistic rate of 57.77% at 1.02 mM according to the assay on HEK293 cell lines in vitro.
Accumulation of Bone-Seeking Radionuclides in Liver Metastasis from Colon Carcinoma
Fifteen colon cancer patients with metastasis to the liver were examined by both liver and bone scans. Seven of these showed accumulation of bone seeking radionuclides in the liver at the site of a defect in the scan. Such accumulation was found in two diphosphonate, in one pyrophosphate and in six 18F scans. To our knowledge, this is the first series to report localization of 18F in intrahepatic metastasis from colon cancer. The precise mechanism for this non-skeletal accumulation is unknown.