The structure of ervinceine
UV spectrum: Xma x (ethanol) 248, 328 m/l (log ~ 4.12, 4.26), which is characteristic for a -methylene indol ine alkaloids. The NMR spectrum of ervinceine with signals at 8 8, 88 (NH, singlet), 6 .14-6 .91 (aromatic protons, 3H), [ 3.69 (singlet, COOCHs), 3.66 (singlet, OCHs), and 0.58 (triplet, --C--C~Hs). I The reduction of ervinceine with zinc in methanoiic sulfuric acid gave dihydroervinceine, C2zHz0NzOz, mp 118:119" C (methanol), [a]~3 +3.3 (c 0.9; chloroform). Its IR spectrum; Xrnax (ethanol) 249, 305 mg (log ~ 3.78, 3.73) is characteristic of ind0tine bases. Its mass spectrum has the molecular peak M + 370 (16%) and also peaks of ions with m/e 339 (M--OCH~) + I0%, 2~4 (M--86) + 26% and 124 (I00%).
Action of alkaline solutions of hydroxamic acids on guanylic acid and RNA
ConclusionsIt has been shown that at pH 10 and 37° C, hydroxamine acids do not react directly with any of the components of ribonucleic acid. Under these conditions the cleavage of the polynucleotide chain takes place at an appreciable rate.
Über die Struktur des Alkaloids Herbacein aus Vinca herbacea W. K.
Chemische und spektroskopische Untersuchungen am Herbacein fuhren zur wahrscheinlichen Struktur 1. Somit erweist sich das Alkaloid als erster Vertreter einer neuen Indolalkaloid gruppe mit einem 16.17-Dihydro-heteroyohimban-Gerust.