A gated electronic switch for stimulation and recording with a single electrode
A circuit design is described for an electronic device which is gate controlled to rapidly switch electrode connections between a stimulator and an amplifier. An integrated switch in the circuit is operated by transistor-transistor logic pulses and will conduct analog signals of up to 15 V amplitude. Electrographic records made using the switch show multi-unit spike discharge after repetitive stimulation of the amygdala in the kindled rat.
Cyclic nucleotides in the amygdala of the kindled rat
The basolateral amygdala of rats was stimulated once daily until three successive fully kindled seizures were elicited. Twenty-four hours after the last seizure the rats were sacrificed by focused microwave irradiation to the head. Tissues from homolateral and contralateral amygdala and cerebral cortex were assayed for cAMP and cGMP content. No significant changes in cyclic nucleotides were measured in the kindled animals. These studies indicate that long term changes in the steady-state level of total tissue cyclic nucleotides do not occur concomitant with the persistently altered excitability associated with kindling of the amygdala.
The application of adsorptive stripping voltammetry for a study of the reaction of human serum albumin with anti-human serum albumin
Abstract Adsorptive stripping voltammetry has been used to study the interaction of human serum albumin with anti-human serum albumin. The adsorptive stripping voltammetric behaviour of both proteins has been optimised with respect to accumulation potential, accumulation time and scan rate. It has been demonstrated that adsorptive stripping voltammetry can be a useful technique for the study of the interaction of these two proteins directly in solution.