Intraspecific Chemical Variability of Essential Oil of Hoslundia opposita
Chemical investigation on leaves oil of Hoslundia opposita, aromatic plant used 
in traditional medicine, harvested from 20 localities of C?te d’Ivoire 
was realized by GC and GC/MS. In total, 101 compounds were identified 
accounting to 92% - 99%, aromatic compounds such benzyl benzoate and sesquiterpenes 
namely germacrene D, β-caryophyllene and α-humulene hydroxyl were found as the major constituents. As regard, 
the chemical profiles of our samples, it was found a great chemical variability 
suggesting a high polymorphism degree. In order to study this chemical 
variability, the results were submitted to the principal components and cluster 
analysis which allowed distinguishing two main groups of essential oils with 
respect to sampling site. The cluster I was dominated by benzyl benzoate (15%) 
and thymol (7.4%) comprising 6 localities, cluster II was characterized by 
phytol (8.5%) and α-humulene (7%) and constituted by 14 localities.
ANTIDYSLIPIDEMIC EFFECT OF LEAF ESSENTIAL OIL OF HOSLUNDIA OPPOSITAVAHL. IN ALLOXAN-INDUCED DIABETIC RATS
Objectives The effect of leaf essential oil of Hoslundia opposita Vahl. on lipid profiles in alloxan-induced dyslipidemic rats was investigated. Forty eight rats were randomly selected into two large normal and diabetic groups, each with four sub-groups. Rats were treated with 110 and 220 mg/kg body weight of the essential oil. All treatments were intraperitoneally administered once a day for four days and data obtained were compared with the standard clinical drug metformin. Hyperglycemia-induced dyslipidemia associated with diabetic complications were normalized on sub-chronic treatment with the oil. Level of total cholesterol, total triglycerides and low density cholesterol (LDL-c) were significantly (p 0.05) from normal control in treated diabetic. The extract also exhibited a dose dependent hypocholesterolemic effect in normal rats. Overall, antidyslipidemic activity of the essential oil extract from leaves of H. opposita may be of benefits in the management of type 2 diabetes and its associated vascular complications
Malabarolide, a novel furanoid bisnorditerpenoid from Tinospora malabarica
A novel furanoid bisnorditerpene has been isolated from the fresh stems of Tinospora malabarica Miers (Menispermaceae) and structurally characterized using X-ray crystallographic and spectroscopic techniques.