Implementing a Korea–Japan Nuclear‐Weapon‐Free Zone: Precedents, Legal Forms, Governance, Scope, Domain, Verification, Compliance and Regional Benefits
To assess the possibility of a future denuclearized Korean peninsula it is important to consider not only US and allied security interests, but also North Korean underlying security concerns. However, beyond the North–South conflict on the Korean peninsula, there is also a longer-term problem of Korean–Japanese relations. Both Japan and South Korea have the capacity to rapidly develop and acquire nuclear weapons. North Korean nuclear acquisition could well provide the rationale for either or both to acquire nuclear weapons. In the Northeast Asian region there is already a lengthy history of denuclearization proposals and even agreements. While the focus of previous proposals had concentrated on the Korean peninsula itself, an alternative way forward would be the initial establishment of a nuclear-weapon-free zone (NWFZ) between Japan and South Korea, with North Korea encouraged to join at a later date. The negotiation of a Korea–Japan NWFZ would serve to confirm and guarantee the current non-nuclear-weapon status of South Korea and Japan, while acting as an important confidence-building step to address North Korea's underlying security concerns and enable it to subsequently join the NWFZ. Internationally, the commitment of the US Obama administration to a reduced reliance on nuclear weapons, the recent unanimous final document of the 2010 Nuclear Non-Proliferation Treaty Review Conference calling for expansion of NWFZs, and the greater openness of the USA and other nuclear powers to NWFZ establishment in areas of regional conflict, suggest that we now have a new window of opportunity for denuclearization of Northeast Asia.
Limited nuclear-weapon-free zones: the time has come
Abstract This paper focuses on the creation, development and current status of the concept of a “limited nuclear-weapon-free zone for Northeast Asia.” While initial work was started in 1991 to develop a system to reinforce the South–North Korean nonaggression and denuclearization treaties, a more formal phase began in January 1995, when a panel of senior military officers met in Atlanta, Georgia. The original panel of general officer-rank specialists from China, Japan, South Korea, Russia and the United States grew in membership to eventually include Mongolia and North Korea, as well as observers from Argentina, Finland and France. The concept was refined in plenary meetings held in Buenos Aires; Bordeaux, France; Moscow; Helsinki; Tokyo; Seoul; Beijing; Ulaanbaatar, Mongolia; Jeju-do, South Korea; Shanghai and Tokyo. The 12th Plenary will be held in Daejeon, South Korea, in October 2008. While the concept of a limited nuclear-free zone has been developed, the international nonproliferation system has com...
Pharmacokinetics of Mivacurium Isomers and Their Metabolites in Healthy Volunteers after Intravenous Bolus Administration
Background Previous studies report the pharmacokinetics of mivacurium isomers after an infusion using venous blood sampling. Although the extent of the mivacurium arterial‐venous gradient is not known, the sampling site is likely to influence mivacurium pharmacokinetic parameters because the drug is rapidly metabolized as it traverses the circulation. The objectives of this study were (1) to determine the pharmacokinetics of mivacurium isomers in healthy persons after intravenous bolus administration using intensive arterial blood sampling, and (2) to characterize the formation and elimination of mivacurium metabolites in human plasma. Methods Eight persons classified as American Society of Anesthesiologists physical status 1 or 2 who were scheduled to undergo elective surgery under balanced anesthesia received 0.15 mg/kg mivacurium chloride as an intravenous bolus. Arterial blood samples were collected every 10 s during the first 2 min and at frequent intervals for 4 h thereafter. Plasma concentrations of mivacurium isomers and their metabolites were determined by two stereoselective high‐performance liquid chromatographic methods coupled with fluorometric detection and noncompartmental pharmacokinetic parameters. Results Mean elimination half‐lives of the trans‐trans, cis‐trans, and cis‐cis isomers were 2.4, 2, and 28.5 min, respectively, with corresponding mean plasma clearances of 29.2, 45.7, and 6.7 ml [center dot] min‐1 [center dot] kg‐1. The volumes of distribution at steady state of the trans‐trans, cis‐trans, and cis‐cis isomers were 0.047, 0.054, and 0.189 l/kg, respectively. Plasma concentrations of monoester and alcohol metabolites peaked 25 s (median) after mivacurium injection, with half‐lives in the range of 90 min, except for the cis alcohol metabolite, which was only negligibly and transiently formed. Conclusions Substantial hydrolysis of mivacurium isomers by cholinesterases was confirmed by the rapid appearance of mivacurium metabolites in plasma. The intensive arterial sampling proved to be critical for the trans‐trans and cis‐trans isomers because the area under the curve between 0 and 2 min accounted for 75% and 86% of the total, respectively.