A cytotoxic diterpenoid and antifungal phenolic compounds from Frullania muscicola steph
A novel ent -labdane type diterpenoid, muscicolone ( 1 ), as well as two bibenzyls ( 2 , 3 ) and four flavonoids ( 4 - 7 ) were isolated from the liverwort Frullania muscicola Steph. Their structures were established by analysis of the spectral data of IR, UV, 1D-, 2D-NMR, and ORD. The stereostructure of 1 was confirmed by X-ray crystallographic analysis. Bioassay experiments showed that compound 3 and 4 have potent inhibitory effects against some fungi while 1 showed cytotoxic effects to some human tumor cells.
Acylated flavone and glycerol glucosides from two Frullania species
Abstract Eight new compounds were identified from Frullania muscicola; five flavone O-glycosides with 3-hydroxy-3-methyl glutaric acid and three glycerol glucosides acylated with caffeic acid, together with three known flavone O-glucosides. From F. polysticta, two known flavone C-glycosides and three new acylated flavone O-glycosides with 3-hydroxy-3-methyl glutaric acid as acyl moiety were characterized.
Terpenoids and aromatic compounds from selected East Malaysian liverworts
Abstract Nine East Malaysian liverworts have been investigated chemically. Frullania serratta produces eudesmane-, germacrane-, eremophilane and elemane-type sesquiterpenoids and bibenzyls and is classified as chemotype I of the Frullaniaceae. Wiesnerella denudata elaborates not only germacranolides but also cyclic bis(bibenzyls), marchantins A and B. The major components of Trichocolea pluma is prenyl 3,4-dimethoxybenzoates, the chemical markers of the Trichocoleaceae. Mastigophora species are chemically almost identical to those of Herbertus because both genera produce unique isocuparene-type sesquiterpenoids and isocuparene dimers. Chandonathus, Heteroscyphus, Lepidozia, Scapania and Schistochila species produce various types of sesquiterpenoids which have been widely distributed in the other liverworts.