Requirements and Constraints for a Robotized Roll Hemming Solution
The objective of this study is the design of a new roller hemming tool. For this purpose, main parameters affecting the final quality of the rolled hemmed part have been studied in order to identify and outline the key factors in roller design as well as in roller hemming process stages. A preliminary set of experiments has been carried out to study the pre-hemming force and springback relation in an aluminium sheet. Experiments showed the required forces in first pre-hemming stage and allowed to calculate a stiffness coefficient based on the springback deformation angle.
The influence of the robot's stiffness on roller hemming processes
Hemming is a widely used joining technology in car body manufacturing. It is mostly used to assemble the structured inner part and the outer part of car body hang on parts like doors, hoods and boot lids. A special hemming technology is roller hemming in which a standard industrial robot is used to join the assembly parts. The properties of the robot do have a significant influence on the process quality. The paper shows the influence of the robot's system stiffness on roller hemming processes. At first the influence of varying robot system stiffnesses on the hemming result is shown. After that a method to predict the stiffness behaviour of the robot is being introduced. The prediction method is validated and compared to real measurements in hemming experiments. Finally, the robots stiffness behaviour along a selected complex hemming path is shown and interpreted.
Atomistic insight into novel co-delivery of doxorubicin and paclitaxel using fullerene modified by dimethyl acrylamide trimethyl chitosan: A computational study

 Background: The distribution of drugs could not be controlled in the conventional drug delivery system. This has led to the development of a smart nanoparticle-based drug delivery system, known as smart drug delivery systems. In cancer research, novel biocompatible nanocarriers have received much attention for various ranges of anticancer drugs.In the current study, the effect of a novel co-polymer "dimethyl acrylamide-trimethyl chitosan" was investigated on drug delivery of doxorubicin and paclitaxel utilizing modified fullerene nanocarrier. This study was performed via molecular dynamics simulation based on acidic pH sensitivity of the cancer microenvironment. Furthermore, hydrogen bonds, diffusion coefficient, gyration radius, and drug-carrier interaction energies were investigated here. Interestingly, a simultaneous pH and temperature-sensitive system was proposed for paclitaxel and doxorubicin for a co-polymer. A pH-sensitive and temperature-sensitive copolymer was used based on trimethyl chitosan and dimethyl acrylamide, respectively. In such a dualistic approach, co-polymer makes an excellent option to have two properties in one bio-polymer. Results: The results suggest the dramatic and indisputable role of the co-polymer in the release of doxorubicin and paclitaxel in cancerous tissues, as well as an increased biocompatibility and drug uptake in a neutral state. The validation test was performed by repeated simulations of a similar article. The results are very close to those of the reference paper .Conclusions: Overall, conjugated fullerene and dimethyl acrylamide-trimethyl chitosan (DMAA-TMC) as carriers can be a good proposition for loading, delivery, and release of anti-cancer drugs based on a pH/temperature-sensitive smart drug delivery system.