Research development of endocrine disrupting chemicals (EDCs) in water in China.
More and more importance has been attached to the problem of endocrine disrupting chemicals (EDCs) since 1960s. This article elaborates the recent research progress of EDCs in water and the trends in the near future in China.
Mutation Effect of Alkyl-hydroxybenzene
The mutation toxicity of the environmental potential endocrine disturbances Alkyl\|hydroxybenzenes has been investigated with Ames test by using the TA97,TA98,TA100 and TA102.The result shows that,except the 2,4-dichlorphenol,the test chemicals such as dimethylphenol,p\|ethylphenol,4\|octanylphenol,nonylphenol,and some chlorophenols have positive responses on the TA98,and the main type of gene mutation is base\|pair frame\|shift.
Fungal Biotransformations in Pharmaceutical Sciences
The regio- and stereoselective conversion of complex substrates represents one of the major advantage of microbial biotransformation. This chapter covers the biocatalytic capacities of fungi to derivatize bioactive small molecules, both from natural sources and from synthetic compounds. We focus particularly on sterol and taxane biotransformation. We also present examples at the interface of biotransformation and pathway engineering using recombinant organisms, with an emphasis on the production of lovastatin derivatives. Finally, we highlight selected studies on fungal xenometabolism which serves as a model to study the breakdown of drugs in mammals.