Study on process parameter of high performance laser cutting machine tool for copper sheet
A high performance NC laser cutting machine tool for copper sheet is designed, emphasis discussing the components of NC laser cutting machine tool and design points. Performance of high power semiconductor pulse micro-cutting of copper sheet is studied and several key parameters are given by changing assistant gas and process parameters. The experimental results show that the best cutting quality can be obtained when argon is used as assistant gas, and oxygen is on the contrary. Also, in a certain range, improving laser power and cutting speed can help in decreasing laser cutting gap, minishing heat affected area, and achieving better cutting quality.
Influence of wire addition direction in C02 laser welding of aluminum
Laser beam welding of aluminum alloys is expected to offer both the technical and economical advantages. In most cases welding wire addition is necessary from the viewpoints to suppress hot cracks, improve mechanical properties of the weld as well as to reduce demands on the edge preparation, fit-up tolerance, and beam alignment. In practice, the filler wire could be added to the weld pool either in the leading or trailing direction. In this experimental work reported, the influence of the wire addition direction on the weld efficiency and process stability was investigated by using a 5kW CO2 laser to weld aluminum alloy 6009 with a plate thickness of 3mm. Beam-on-plate welds were made either in the autogeneous mode or with filler wire AISi12. Illuminated by a double frequency Nd:YAG laser, the weld pool dynamics and the wire melting process were observed applying a high speed camera. The experimental results demonstrate that welding with filler wire in the trailing direction is more efficient and stable than in the leading direction. High speed camera photographs show that the filler wire is mainly melted through weld pool heating and plasma heating in the former case and through direct laser irradiation and plasma heating in the later case. The weld pool is of vibration when welding in the autogeneous mode or with filler wire in the leading direction. However, the weld pool is much calmer when the wire is added in the trailing direction to the weld pool.
Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform
This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, the effectiveness of 20 dicarboxylic acids to generate a specific cross-linked hydrogel capable of supporting different amounts of γ-cyclodextrin (γ-CD) was evaluated. According to the interaction energies calculated with the in-silico studies, the hydrogel made from PVA cross-linked with succinic acids (SA) was shown to be the best candidate for containing γ-CD. Later, molecular dynamics simulation studies were performed in order to evaluate the intermolecular interactions between PDN and three cross-linked hydrogel formulations with different proportions of γ-CD (2.44%, 4.76% and 9.1%). These three cross-linked hydrogels were synthesized and characterized. The loading and the subsequent release of PDN from the hydrogels were investigated. The in-silico and experimental results showed that the interaction between PDN and γ-CDHSA was mainly produced with the γ-CDs linked to the hydrogels. Thus, the unique structures and properties of γ-CDHSA demonstrated an interesting multiphasic profile that could be utilized as a promising drug carrier for controlled, sustained and localized release of PDN.