(a New Proposal to Jefferson Lab 12 Gev -pac34) Measurement of the Semi-inclusive Π and K Electro-production in Dis Regime from Transversely Polarized He Target with the Sbs & Bb Spectrometers in Hall A
An experiment is proposed to measure the Single Spin Asymmetries of the Semi-Inclusive Deep Inelastic Scattering (SIDIS) process ~n(e, e′π±(K±)), using the large-solid-angle Super Bigbite Spectrometer (SBS), the BigBite Spectrometer, and a novel polarized He target that includes alkali-hybrid optical pumping and convection flow to achieve very high luminosity. Both spectrometer arms will utilize GEM-based tracking to accommodate the high rates. The abundant statistics will allow the determination of the Collins and Sivers functions for neutron roughly 10 times more accurate than obtained for proton at HERMES for a detailed grid of the kinematic variables x, p T , and z. Furthermore, by including data taking at two energies, an 8.8 and 11 GeV, we will have data at two values of Q for each bin in x. The azimuthal coverage of our experiment is excellent, and is facilitated by collecting data at a series of neutron polarization directions, always transverse to the beam direction. The SIDIS pions and kaons will be detected over a wide range of the hadron momenta above 2 GeV for the angle between the hadron production and the electron scattering planes up to ±60◦, and the angle between the hadron momenta and the virtual photon momenta up to 60◦. Between the large acceptances of the electron and hadron arms, an electron polarizednucleon luminosity on the level of 4 · 10 cm−2/s, and a target polarization of 65%, we will obtain in a two-month run about 100 times more statistics (after accounting for difference in polarization and dilutions) then was done by the HERMES experiment. The experiment has significant potential for the discovery of new effects in hadron physics.
Pretzelosity distribution function
H. Avakian,1 A. V. Efremov,2 P. Schweitzer,3,4 F. Yuan5,6 1 Thomas Jefferson National Accelerator Facility, Newport News, VA 23606, U.S.A. 2 Joint Institute for Nuclear Research, Dubna, 141980 Russia 3 Inst. f. Theoret. Physik II, Ruhr-Universität Bochum, D-44780 Bochum, Germany 4 Departement of Physics, University of Connecticut, Storrs, CT 06269, U.S.A. 5 RIKEN BNL Research Center, Building 510A, BNL, Upton, NY 11973, U.S.A. 6 Nuclear Science Division, Berkeley National Laboratory, Berkeley, CA 94720, U.S.A.
Calyculins and Related Marine Natural Products as Serine-Threonine Protein Phosphatase PP1 and PP2A Inhibitors and Total Syntheses of Calyculin A, B, and C
Calyculins, highly cytotoxic polyketides, originally isolated from the marine sponge Discodermia calyx by Fusetani and co-workers, belong to the lithistid sponges group. These molecules have become interesting targets for cell biologists and synthetic organic chemists. The serine/threonine protein phosphatases play an essential role in the cellular signalling, metabolism, and cell cycle control. Calyculins express potent protein phosphatase 1 and 2A inhibitory activity, and have therefore become valuable tools for cellular biologists studying intracellular processes and their control by reversible phosphorylation. Calyculins might also play an important role in the development of several diseases such as cancer, neurodegenerative diseases, and type 2-diabetes mellitus. The fascinating structures of calyculins have inspired various groups of synthetic organic chemists to develop total syntheses of the most abundant calyculins A and C. However, with fifteen chiral centres, a cyano-capped tetraene unit, a phosphate-bearing spiroketal, an anti, anti, anti dipropionate segment, an α-chiral oxazole, and a trihydroxylated γ-amino acid, calyculins reach versatility that only few natural products can surpass, and truly challenge modern chemists’ asymmetric synthesis skills.