Two new components from the roots of Angelicae koreana Kitagawa
Two new compounds, 2-hydroxyethylcarboxylic acid-5,9-eicodien-carboxylate and 1-(2′-propenoxy)undec-2-ene, and two known compounds, 2-hydroxy-4-methyl-acetophenone and β-sitosterol, were isolated from the roots of Angelicae koreana Kitagawa. The structures of the compounds were established on the basis of MS and NMR spectral data.
Identification and antifungal activity of novel organic compounds found in cuticular and internal lipids of medically important flies.
Novel organic compounds found in the cuticular and internal lipids of medically important flies were identified. Uracil, 9-tricosene, 1-oleoyl glycerol, dimethyl suberate and butyl stearate were tested for their potential antifungal activity. Minimal inhibitory concentrations of the compounds against reference strains of fungi were determined. Uracil and dimethyl suberate slightly inhibited the growth of entomopathogenic fungi. The cuticular and internal lipids of Calliphora vicina, Calliphora vomitoria, Sarcophaga carnaria and Musca domestica were studied by gas chromatography (GC) combined with mass spectrometry (GC/MS). A comparison of the lipid extracts between the preimaginal and mature stages showed adults flies contained a higher total content of the identified components. Furthermore, their amounts distinctly predominated in the internal lipids of all the species. The amount of 9-tricosene was the highest in adults of C. vicina, while the larvae and pupae had a definitively lower amount of this compound. Uracil was found to be the most abundant component in extracts obtained from C. vomitoria especially in the internal lipids of adults. 1-oleoyl glycerol was detected in all of the examined species of flies. It was most abundant in the internal extracts isolated from the larvae of C. vicina and the pupae of C. vomitoria. Suberic acid dimethyl ester was found in the larval and pupal internal lipids of C. vicina and S. carnaria in low amounts. Butyl stearate was identified only in the internal lipids of the larvae and adults of houseflies.
The costs of identifying undiagnosed prostate cancer in asymptomatic men in New Zealand general practice
Background. Screening for prostate cancer (PCa) using the prostate-specific antigen (PSA) test is widespread in New Zealand. 3 informed testing history in 2007–09 were NZ$8887 compared to NZ$13 870 if the men had PSA tests in 2007–09. If we assumed a PSA test involved a full 15-minute general practice consultation, the estimated costs increased to NZ$26 877 per PCa identified. Conclusions. Screening of asymptomatic men for PCa is widely practiced. Most of the costs of screening were incurred in general practice. Calls for men to receive increased information on the harms and benefits of screening will substantially increase the costs. The current costs could be reduced by better targeting of screening.