Synthesis and fungitoxicity of some pyrimidine derivatives
A series of 12 pyrimidine derivatives were prepared and testedin vitro against growth, sporulation and nucleic acid content ofFusarium oxysporum f. sp.lycopersici andHelminthosporium oryzae. Introduction of a thiazole ring together with two aryl groups into 2-aminopyrimidine brought about drastic toxicity for both fungi. Pyrimidine derivatives with aryl groups alone were less toxic. Nitro groups were found to enhance the toxicity of the pyrimidine derivatives especially when substituted in the ortho-position of the aryl groups. Inhibition of nucleic acid synthesis of both fungi was attributed mainly to the presence of the thiazole ring.
SYNTHESIS OF 1,3,5-TRIAZINE BASED PYRIMIDINES AS POTENT ANTI-BACTERIAL AND ANTI-FUNGAL AGENTS
Objectives: Pyrimidines and 1,3,5-triazines play an important role in many biological processes. 2,4,6-trichloro-1,3,5-triazine (TCT) provides a good opportunity to a chemist in the synthesis of its various derivatives by the replacement of its chlorine atom with bioactive pharmacophores at three different temperatures. Hence, present work was carried out keeping in mind that combination or addition of two or more pharmacophores may enhance the biological activities with wide spectrum of their pharmacological profile. Methods: Chalcone derivatives of [(E)-1-(4-(4,6-bis(pyrimidine-2-ylamino)-1,3,5-triazine2-ylamino) phenyl)-3(pyridine-2-yl)prop-2-en-1-one & (E)-3(pyridine-2-yl)-1-(4-(4-(4-(E)-3-(pyridine-2-yl)acryloyl)phenylamino)6-(pyrimdine-2-ylamino)-1,3,5-triazine-2-ylamino)phenyl)prop-2-en1-one] were prepared to explore to provide an easy one pot synthesis with urea, thiourea and guanidine to furnish pyrimidine analogues. All the compounds synthesized were characterized elemental analysis and IR, 1 H NMR, MS data. Conclusion: Compound 2 and 8 has been found to possess good anti-bacterial and anti-fungal activity.
Two novel antifungal alka-2,4-dienals from Triticum aestivum
Abstract Two novel antifungal compounds have been isolated from water extracts of the shoots of Triticum aestivum cv Maris Huntsman, and characterized as 4-