A novel Salvialactomine from the callus culture of Salvia santolinifolia Boiss
Abstract A novel compound Salvialactomine (1) along with two other unusual occurring natural products Pentatriacontanoic acid 1, 3-dihydroxypropyl ester (2) and 5-Methylflavone (3) were isolated from the callus of Salvia santolinifolia Boiss. Callus was initiated on MS medium containing NAA (0.5 mg/L) and further sub-cultured on MS medium supplemented with NAA with BA (0.5 + 1.5 mg/L). The structures of isolated compounds were determined by using mass spectrometry, 1D, and 2D–NMR techniques. Compounds 1, and 3 were tested for two different cancer cell lines, i.e. Hela (Cervical cancer cell) and PC-3 (Prostate cancer cells). IC50 was found as > 30 using Doxorobicin (0.912 ± 0.12 μmol L−1) as a standard.
Synthesis of the Anti-Melanogenic Glycerol Fatty Acid Ester Isolated from the Tuber-Barks of Colocasia antiquorum var. esculenta
(2′ S )-1- O -9-Oxo-(10 E ,12 E )-octadecadienoyl glycerol, a natural anti-melanogenic monoglyceride, is synthesized for the first time. The chiral pool based route employed not only confirms the absolute configuration, but also illustrates the first synthetic entry to the ( E , E )-diene keto acid, which is another molecule of biological importance. The confusion caused by the misinterpreted 1 H NMR spectroscopic data for the ( E , E )-diene motif in the literature is discussed. The first unequivocal piece of evidence for the assigned (12 E ) configuration is also presented.
Nietzsche's Moral Philosophy
Expounds and criticizes the moral consequences of Nietzsche's basic concept of the will to power. This study argues that Nietzsche's doctrines on moral subjects reveal a man profoundly torn between different and conflicting impulses.