Synthesis of chiral amino cyclic phosphoric acids
Chiral amino cyclic phosphoric acids, 5-amino-2-hydroxy-4-(4-nitrophenyl)-1,3,2-dioxaphosphorinane 2-oxide and 2-hydroxy-4-(4-methylsulfonylphenyl)-5-phthalimido-1,3,2-dioxaphos phorinane 2-oxide are synthesized in good over yields (64.2% and 72.8% respectively) from 2-amino-1-aryl-1,3-propanediols. The different reaction conditions are necessary in hydrolysis reactions of amino cyclic phosphonyl chlorides.
SYNTHESIS OF CYCLIC SPHINGOSINE 1,3-PHOSPHATE (CSPP) THROUGH A PHOTOLYTIC REACTION
Abstract The synthesis of cyclic sphingosine 1,3-phosphate through photolytic methodology is described starting from d - erythro -sphingosine. A bifunctional phosphorylating reagent, 2-cyanoethyl N,N -diisopropylchlorophosphoramidite, is used to introduce the cyclic 1,3-phosphate moiety. This procedure generates cSPP in four steps and in 36% overall yield.
An efficient synthesis of sphingosine-1-phosphate
Abstract The total synthesis of D- erythro -sphingosine-1-phosphate ( 2 ) via the phosphoramidite approach, starting from 3-O-TBDMS-protected D- erythro -azidosphingosine 3 is described.