A high speed 16 kbit ECL RAM
A 16384 /spl times/ 1 bit ECL RAM (emitter coupled logic random access memory) with an access time of 15 ns and a power dissipation of 700 mW has been developed. The high packing density and performance were achieved by using a p-n-p load cell, a novel ECL circuit, and U-groove isolation. The test results proved that a p-n-p load cell is very effective in producing a fast high-density bipolar RAM having a capacity of over 64 Kbits.
MOS and Bipolar Memory Circuit Techniques
Digital integrated circuits have seen phenomenal developments in terms of speed, density and functionally. These have been brought about by developments in VLSI technology, improvements in circuit techniques, novel system approaches and design methodology and the pressure of modern system requirements. In fact memories have been recognized to be technology drivers in enhancement of speed and density. Developments in integrated circuit logic and memory have been surveyed. Performance improvements in RISC and CISC have created a demand for ever improving performance. Systems with cycle times greater than 20 MHz have become common place and often require access times in the 20–40 ns range. The embedded control systems require significance non-volatile storage. Large memories with high speed are specially required to meet the demands of video signal processing, graphics and character recognition.The present survey discusses some of the above developments in memory, in particular, circuit techniques involved i...
Mode of action of bredinin with guanylic acid on L5178Y mouse leukemia cells.
Moderate concentrations of bredinin (1.2 X 10(-5) M) strongly inhibited growth of L5178Y cells, with the effect being reversed by guanylic acid (GMP). However, at higher concentrations of breeding the inhibition was not reversed completely by GMP added in excess. Bredinin was cytocidal at concentrations above 2 X 10(-5) M, but 5 X 10(-5) M bredinin in the presence of excess GMP, bredinin was cytostatic. Bredinin inhibited nucleic acid synthesis of L5178Y cells, but bredinin itself was not incorporated into the nucleic acid. Inhibition of nucleic acid synthesis was clearly reversed by GMP. Similarly chromosomal aberrations in L5178Y cells caused by bredinin were reversed by GMP. In contrast, the effect of ahigh concentration of bredinin on cell multiplication was not reversed by GMP. The modal volume of L5178Y cells increased during incubation in the presence of bredinin and GMP for 24 hours, 5 X 10(-5) M bredinin with GMP causing a 70% increase in cell volume. This increase in cell volume was mainly due to an increase in the protein content of the cells. The cytostatic effect of bredinin with GMP was reversed completely by adenosine-3',5'-cyclic monophosphate (cyclic AMP). Other cyclic nucleotides and nucleotides were ineffective. The reversing effect of cyclic AMP on cell survival depended upon the concentration of GMP, and was not seen in the absence of GMP. It was concluded that cyclic AMP influences the secondary cytostatic effect of bredinin, and not the primary cytotoxic effect reversed by GMP.