On a new form of reagent against perspiration effects on shoe materials
In a discussion of a series of tests connected with the fastness of colours on textile fibres, Villavecchia (1918) mentions the use of neutral ammonium acetate or common salt solution for measuring the colour resistance to perspiration. Thus in the case of coloured cotton, this is immersed for 10 min. alongside an equal quantity of white cotton yarn in a 0·1% aqueous ammonium acetate at 80°C., and the extent of colouring of the yarn as well as the degree of stripping of the coloured sample noted after drying without rinsing. An odd number of degrees of fastness is arbitrarily assigned to the coloured specimen according to the result, e.g. V degrees if neither the original tint nor the whiteness of the yarn is changed. Similarly with linen, hemp and ramie. For coloured wool both methods are used, viz. with sodium chloride and with ammonium acetate. In the former case, the alteration in colour is noted after simply dipping the wool in salt solution and allowing to air-dry out at room temperature. In the latter case, an equal quantity of white zephyr wool in addition to the white cotton is present. V degrees in all cases are stated to be conventionally adopted between industrial associations and dyestuff manufacturers for materials which are fast enough to reveal no change whatever in the testing bath. For coloured silk there are no precise data, and usually it is immersed in distilled water for several days to ascertain if any colour is lost.
Dissolution of materials in artificial skin surface film liquids.
The dissolution of chemical constituents from jewelry, textiles, cosmetics, drugs, industrial chemicals, and particles in direct and prolonged contact with human skin is often assessed in vitro using artificial skin surface film liquids (SSFL). To provide meaningful results, the composition of artificial SSFL should accurately mimic human sweat and sebum, and the conditions of the in vitro test system should accurately reflect in vivo skin conditions. We summarized the reported composition of human SSFL and compared it to 45 different formulations of artificial sweat and 18 formulations of artificial sebum (studies published from 1940 to 2005). Conditions of in vitro dissolution test systems were reviewed and compared to in vivo skin conditions. The concentrations of individual constituents and pH of artificial sweat and concentrations of artificial sebum constituents are not always within ranges reported for human SSFL. Nearly all artificial SSFL lack many of the constituents in human SSFL. To develop a comprehensive model SSFL, we propose a standard SSFL, modified from the two best published sweat and sebum formulations. Little is known concerning the influence of test system conditions on dissolution, including SSFL temperature, container material composition, agitation, and physicochemical properties of the test article on dissolution. Thus, both a need and an opportunity exist for standardizing the composition of artificial SSFL and in vitro dissolution test methodologies. To standardize in vitro dissolution test systems, we recommend: maintaining artificial SSFL at a biologically relevant temperature appropriate to the human activity being modeled, carefully selecting test and sample storage containers to avoid bias in dissolution measurements, accounting for friction between a test article and skin in a biologically plausible manner, and physicochemical characterization of the test article or material to better understand mechanisms of dissolution and potential mechanisms of toxic action of dissolved material. More accurate modeling and better understanding of chemical dissolution from articles in contact with the skin will ultimately improve risk decision making, thereby protecting even the most susceptible persons from adverse health effects resulting from skin exposure.
A Text-book of Physiological Chemistry
PROF. OLAF HAMMARSTEN has resigned the chair he held for so many years at Upsala, but one is rejoiced to learn he has not relinquished work in the field where he has done such important service. Original papers from his pen still appear in the journals, and his well-known text-book continues to flourish, and has now reached a seventh German edition. The translation of this has, as in the past, been carried out by Prof. J. A. Mandel, of New York, who has performed what in his preface he terms a labour of love with his usual efficiency.A Text-book of Physiological Chemistry.By Prof. O. Hammarsten. Authorised translation from the author's enlarged and revised seventh German edition, by Prof. J. A. Mandel. Sixth edition. Pp. viii + 964. (New York: J. Wiley and Sons; London: Chapman and Hall, Ltd., 1911.) Price 17s. net.