DEVELOPMENT AND EVALUATION OF DROTOVERINE TASTE MASKED TABLETS WITH IMPROVED DISSOLUTION EFFICIENCY USING SOLID DISPERSION TECHNIQUE
The purpose of this research is to mask the bitter taste of the drug, Drotoverine using solid dispersion technique. The taste-masked drug is formulated in to a conventional tablet by direct compression method for ease of administration. Taste masking was done by solid dispersion using polymer such as urea and mannitol by melting/fusion method Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM) were performed to identify the physicochemical interaction between drug and carrier, hence its effect on dissolution. Conventional taste masked tablets were evaluated for weight variation, disintegration time, hardness and friability. In vitro drug release studies were performed for conventional tablets of drotoverine. Bitterness score was evaluated on volunteers. FTIR spectroscopy and SEM showed no interaction between drug and carriers. Conventional tablets prepared using solid dispersion, showed faster disintegration and complete bitter taste masking of drotoverine. In addition the prepared tablets exhibited better dissolution profile. Taste evaluation of taste masked tablets in human volunteers rated tasteless with a score of 0. Thus, results conclusively demonstrated successful masking of taste and oral disintegration of the formulated tablets in the oral cavity with improved dissolution.
FORMULATION AND EVALUATION OF FAST DISSOLVING TABLETS OF OLMESARTAN MEDOXOMIL BY USING CO- PROCESSED EXCIPIENTS TECHIQUE
In the present work, fast dissolving tablets of Olmesartan medoxomil were prepared using novel co-processed superdisintegrants consisting of crospovidone and croscarmellose sodium in different ratios (1:1, 1:2 and 1:3).Olmesartanmedoxomil (OLM) is an angiotensin II receptor blocker used for the treatment of hypertension. In present work an attempt was made to mask the metallic taste and enhance the solubility and dissolution rate of poorly soluble OLM by formulating it as inclusion complexesby kneading method with β-cyclodextrins (β-CDs) as complexing agentin 1:1 molar ratio. Effect of co-processed superdisintegrants on pre-formulation parameters, wetting time, disintegrating time, drug content and in-vitro release have been studied. Drug compatibility with excipients was checked by FTIR and DSC studies. The co-processing of the superdisintegrants was done by solvent evaporation. The values of pre-compression parameters evaluated were within prescribed limits and indicated good free flowing property. From the prepared inclusion complexes and co-processed excipients, fast dissolving tablets (FDTs) were formulated. In all the formulations, hardness test indicated good mechanical strength results ranging from 2.89 to 3.81 kg/cm 2 , friability is less than 1%indicated that tablets have good mechanical resistance. Wetting time is an important criteria for understanding the capacity of disintegrants to swell in presence of little amount of water were found to be in the range of 7.33 to 14.66 seconds. Disintegration time was found to be in the range of 8.33 to 20.00 seconds. Drug content was found to be in the range of 97.36 to 99.72 %. Among all the designed formulations, formulation CPI3 i.e.co-processed excipients having ratio CSS:CP (1:3) containing 5% w/w of co-processed superdisintegrants, was found to be promising and was displayed an in-vitro dispersion time of 8.33 seconds, which
Review of Literature on Probability of Detection for Magnetic Particle Nondestructive Testing
Abstract : A critical review of the available literature concerning the minimum reliably detectable defect size aNDI for magnetic particle testing (MPT) in aerospace applications is presented. Four probability of detection (POD) studies relevant to detection of fatigue cracks in aircraft components were found over the period 1968 to 2011. As the statistical methods used in these four previous studies were either outdated or otherwise deficient, the original data were reanalysed using currently accepted techniques. A meta-analysis of the results is presented, with emphasis on statistical inferences for the defect size expected to be detected with 90% POD. It is shown that the minimum reliably detectable defect size aNDI = 2.0 mm currently specified by the Royal Australian Air Force for wet fluorescent magnetic particle inspection using the continuous method is consistent with estimates of the average performance of MPT derived from the reanalysis of the literature.