An elegant synthesis of Zetaclausenamide.
Zetaclausenamide, which was isolated as a hepatoprotective agent from the leaves of medicinal plant Clausena lansium, was synthesized for the first time in six steps including Darzen's condensation, photoisomerization, and the final cyclization reactions.
Palladium-catalyzed intramolecular C–H amidation: synthesis and biological activities of indolobenzazocin-8-ones
Abstract The synthesis of multi ring-fused indolobenzazocinone derivatives, an antimitotic agent, has been carried out using palladium-catalyzed C–H activation/intramolecular amidation of benzo[ d ]azocinones, which were synthesized by the ring annulations of dihydroisoquinolines and azlactone in refluxing acetonitrile. The target compounds, indolobenzazocin-8-one derivatives, were evaluated for their cytotoxicity against the cancer cell lines HUCCA-1, A549, HepG2, and MOLT-3. The results showed that an unsubstituted indolobenzazocin-8-one 1e exhibited very good activities in the nanomolar IC 50 value range (HepG2 and MOLT-3).
Procedure for the catalytic asymmetric epoxidation of allylic alcohols in the presence of molecular sieves
Etude de l'epoxydation du (E)-undecene-2ol-1 et du (E)-dimethyl-3,7 octadiene-2,6ol-1 (geraniol) par action de l'hydroperoxyde de t-butyle en presence de propanolate-2 de titane IV, de tartrate de diethyle et de tamis moleculaire