Secoiridoid analogues from the fruits of Ligustrum lucidum and their inhibitory activities against influenza A virus.
A phytochemical study focusing on the secoiridoid components in the fruits of Ligustrum lucidum was carried out, which finally led to the isolation of nine secoiridoid glycosides (1-9) together with two secoiridoids (10, 11). The structures of all compounds were established mainly by NMR and MS experiments as well as the necessary chemical evidence, of which 1, 2, 4 (ligulucisides A-C), 10 and 11 (liguluciridoids A and B) were identified as new secoiridoid analogues. An in vitro antiviral bioassay indicated that 1, 4, 6, and 10 displayed the inhibitory activities against influenza A virus with the IC50 values of 16.5, 12.5, 13.1, and 18.5 μM, respectively, which were better than the positive control Ribavirin (IC50 22.6 μM). .
A secoiridoid dilactone fromFraxinus ornus bark
SummaryThe isolation and structure elucidation of the secoiridoid hydroxyornoside is described. The behaviour of secoiridoid dilactones on acid methanolysis is discussed.ZusammenfassungDie Isolierung und Strukturaufklärung des Secoiridoids Hydroxyornosid wird beschrieben. Das Verhalten von Secoiridoiddilactonen bezüglich saurer Methanolyse wird diskutiert.
Chemical Consituents of Petroleum Ether Extract from Fruits of Ligustrum lucidum
OBJECTIVE To investigate the chemical constituents of petroleum ether extract fraction from the fruits of Ligustrum lucidum.METHODS Chemical constituents were isolated by various chromatographic techniques,and their structures were identified on the basis of spectroscopic data and physico-chemical properties.RESULTS Eleven compounds were isolated and identified,including(132-S)-hydroxyphaeophytin a(1),(132-R)-hydroxyphaeophytin a(2),β-sitosterol(3),stigmasterol(4),betulinic acid(5),(E)-3β,20-dihydroxy-25-perhydroxydammar-23-ene(6),20(S)-3β,20-dihydroxy-24-perhydroxydammar-25-ene(7),acetyloleanolic acid(8),oleanolic acid(9),lupeol(10),and betulin(11).CONCLUSION Compounds 1-5 were isolated from this plant for the first time.