Protective effect of inactivated bovine herpesvirus-1 in calves experimentally infected with bovine herpesvirus-1 and Pasteurella haemolytica.
The protective effect of an inactivated whole-virion bovine herpesvirus-1 (BHV-1) immunising inoculum, without adjuvant, against viral-bacterial respiratory disease was studied in three experimental treatment groups of five calves each. One group was boosted 14 days after the first vaccination and at this time the second group received their initial inoculation. Seven days later, calves were challenged with BHV-1 in aerosol and four days after this challenge all calves were exposed to Pasteurella haemolytica A1 in aerosol. Among the three groups, differences in rectal temperature responses four days after viral challenge (P less than 0.01) did not relate to protection. However the main response variable, viral-bacterial pneumonia, was reduced in boosted calves (P less than 0.05).
Veterinary vaccines: alternatives to antibiotics?*
Abstract The prevention of infectious diseases of animals by vaccination has been routinely practiced for decades and has proved to be one of the most cost-effective methods of disease control. However, since the pioneering work of Pasteur in the 1880s, the composition of veterinary vaccines has changed very little from a conceptual perspective and this has, in turn, limited their application in areas such as the control of chronic infectious diseases. New technologies in the areas of vaccine formulation and delivery as well as our increased knowledge of disease pathogenesis and the host responses associated with protection from disease offer promising alternatives for vaccine formulation as well as targets for the prevention of bacterial disease. These new vaccines have the potential to lessen our reliance on antibiotics for disease control, but will only reach their full potential when used in combination with other intervention strategies.
First Along the River: A Brief History of the U.S. Environmental Movement
Chapter 1: Philosophical Foundations Chapter 2: The 1400s through the 1700s: Inhabiting a New Land Chapter 3: The Early 1800s: Destroying the Frontier Chapter 4: The Late 1880s: Building an Industrial Nation Chapter 5: The 1900s through the 1930s: Beginnings of the Conservation Movement Chapter 6: The 1940s through the 1960s: Prelude to the Green Decade Chapter 7: The 1970s: The Conservation Movement Matures Chapter 8: The 1980s: A Conservative Backlash Chapter 9: The Early 1990s: Government Retrenchment and Public Apathy Chapter 10: The Environmental Movement in the Post-9/11 World Conclusion