Methyl 3-(Quinolin-2-yl)indolizine-1-carboxylate
A novel compound, methyl 3-(quinolin-2-yl)indolizine-1-carboxylate (2) has been synthesized by cycloaddition reaction of 1-(quinolin-2-ylmethyl)pyridinium ylide (1) with methyl propiolate in presence of sodium hydride in THF. The structure of this compound was established by IR, 1H-NMR, 13C-NMR and MS data
SYNTHESIS OF NEW HETEROCYCLIC RING SYSTEMS: INDENO[2,1-B]-BENZO[G]INDOLIZINE AND INDENO[1',2':5,4]PYRROLO[2,1-A]PHTHALAZINE
Some derivatives of the title heterocycles have been prepared by a «one step» synthesis from 2-hydroxy-2-acylmethylene-1,3-indandiones, tosyl chloride and isoquinoline or phthalazine. The synthesis of new indeno[2,1-b]indolizine derivatives performed by using pyridine as base is also reported
Recent progress in synthesis and bioactivity studies of indolizines.
The present review describes the recent progress in synthetic approaches to construct indolizine framework (including partially or wholly reduced ring) and the design of such compounds with potential biological activity. The methods of synthesis are classified as the Tschitschibabin reaction, 1,3-dipolar cycloadditions, cyclisation reactions depending on the position of bond formation, and other methods. The biological activities include antimicrobial activity, antioxidant activity, anti-inflammatory activity, anticonvulsant activity, enzymes inhibition activity and activity as calcium entry blocker. Consequently this review emphasizes the significant development in synthetic methods of indolizines during the current decade, and the importance of indolizines in drug discovery.