Structures of minor components of the validamycin complex.
complicated oligosaccharides using NMRspectroscopy have developed quite remarkably. The structure of validamycin G (VM-G),43 the most recently discovered congener was established by making use of these techniques. Wehave now used NMRto reinvestigated the position of the glycosidic linkage of the minor components which had remained obscure. The results were first disclosed in a patent application,53 though without experimental data. Here we discussed the structures of the minor components with experimental results. To elucidate the unidentified positions of the glucosidic linkage by *H NMRspectroscopy, VM-B~ F were acetylated with acetic anhydride and pyridine to give the corresponding peracetyl derivatives. The chemical shifts of 1-H and l'-H of the peracetates, recognized in the region of 3.2~3.6 ppm, indicate that the imino group is not acetylated. Therefore, these peracetates must be dodeca-O-acetyl validamycin B (Ac-
The C7N aminocyclitol family of natural products.
This review covers microbial secondary metabolites classified in the family of C7N aminocyclitols, a relatively new class of natural products that is increasingly gaining recognition due to their significant biomedical and agricultural uses. Their discovery and structure determinations, their biosynthetic origin, biological properties, chemical synthesis, as well as their further development for pharmaceutical uses are described. The literature from 1970 to July 2002 is reviewed, with 269 references cited.
Relationship between level of internet addiction and time management skills among nursing students.
PURPOSE
This study investigated nursing students' levels of internet addiction (IA) and time management (TM) skills.


DESIGN AND METHODS
This cross-sectional descriptive study was conducted with 400 nursing students of a university in Turkey. The data were collected using the Personal Information Form, IA Scale, and TM Inventory.


FINDINGS
The IA scale and TM inventory mean scores were 40.83 ± 14.81 and 81.34 ± 11.91, respectively. A significantly negative relationship between students' level of IA and TM skills was found (p <0.05).


PRACTICE IMPLICATIONS
The concept of effective time management should be used in interventions for promoting students' conscious internet use.