Structures of 5,5-disubstituted cyanoiminobarbituric acids
O. A. Erastov, S. N. Ignat'eva, and T. V. Malkova, Khim. Geterotsikl. Soedin., No. i0, 1313-1319 (1971). Japanese Patent No. 8271; Ref. Zh. Khim., No. 16, 58000P (1959). Japanese Patent No. 8871; Ref. Zh. Khim., No. 18, 74348P (1960). Japanese Patent No. 9538; Ref. Zh. Khim., No. 9, N79P (1971). B. I. Shapira, A. A. Malina, G. Z. Yakovleva, et al., Khim.farm. Zh., No. 6, 46-49 (1969). F. Korte and F. Wusten, Tetrahedron, 19, No. 9, 1423-1436 (1963).
Orthoamide, IX über die Umsetzung CH‐acider Verbindungen mit Amidacetalen, einem Aminal‐tert.‐butylester und Tris‐dimethylamino‐methan
Orthoamide reagieren mit wasserfreier Blausaure und Alkinen zu 2-Dimethylamino-2-alkoxy-nitrilen (2, 4, 6, 8, 10), 2.2-Bis-dimethylamino-nitrilen (12, 12a) und 3.3-Bis-dimethylamino-alkinen-(l) (14–16). Aus Methan-Derivaten und Dimethylformamid-diathylacetal (1) ent-stehen in der Warme die alkylierten Methan-Derivate (25, 26, 28, 29, 30, 34) und mit dem Aminal-tert.-butylester 11 unter milden Reaktionsbedingungen die Tetramethylformamidini-um-Salze(31,32, 33,35). 
 
 
 
Orthoamides, IX: Reaction of CH-Acidic Compounds with Amide Acetals, an Aminal-tert-butylester and Tris(dimethylamino)methane 
 
 
 
Orthoamides react with hydrogen cyanide and alkynes to give 2-dimethylamino-2-alkoxy-nitriles (2, 4, 6, 8, 10), 2,2-bis(dimethylamino)nitriles (12,12a), and 3,3-bis(dimethylamino)-alkynes (14–16). Methane derivatives heated with dimethylformamide diathylacetal (1) react to form the alkylated methane derivatives (25, 26, 28, 29, 30, 34), whereas under mild conditions methane derivatives react with the aminal tert-butylester 11 to produce tetramethyl-formamidinium salts (31, 32, 33, 35).
Melanocins A, B and C, new melanin synthesis inhibitors produced by Eupenicillium shearii. I. Taxonomy, fermentation, isolation and biological properties.
New melanin synthesis inhibitors, melanocins A, B and C, were isolated from the fermentation broth and mycelium extract of Eupenicillium shearii F80695. Melanocin A, an isocyanide compound, inhibited mushroom tyrosinase and melanin biosynthesis of B16 melanoma cells with IC50 value of 9.0 nM and MIC value of 0.9 microM, respectively. Melanocin A also inhibited growth of Streptomyces bikiniensis. While, the structurally very related but non-isocyanide compounds melanocins B and C did not show inhibitory activity in these assays. Melanocins A, B and C showed potent antioxidant activity with scavenging activity of DPPH radical and superoxide anion radical.