Chemical structure and fungicide selectivity
The influence of stereo- and other isomers, homologues and structural variations on the activity of various types of systemic fungicides is reviewed.
Investigations on fungicides: XIV. Fungitoxicity of N‐(2,2,2–trichloro‐1–methoxyethyl)‐formamide and related compounds
SUMMARY 
 
From a study of forty compounds related to the systemic fungicide N,N'-bis(1–formamido-2,2,2–trichloroethyl)-piperazine, known as triforine (CELAW524), it was found that a new compound, N-(2,2,2–trichloro-1–methoxyethyl)-formamide, controls Erysiphe graminis on wheat when applied to the roots in sand. A number of N-(2,2,2–trichloro-1–aryloxyethyl)-form-amides and alkyl N-(2,2,2–trichloro-1–arylaminoethyl)-carbamates protect broad beans against Uromyces fabae and wheat against Erysiphe graminis; some of these formamides show slight activity when applied to plant roots.
Investigations on fungicides
SUMMARY 
 
The structure/anti-fungal relationships of a group of 137 sulphur-containing compounds were studied by observation of their effects on the mycelial growth of six fungi, Pythium ultimum, Sclerotinia fructigena, Verticillium albo-atrum, Alternaria solani, Botrytis cinerea and Aspergillus niger, and the germination of spores of Botrytis cinevea. These compounds consist of (a) salts and (b) carboxy-alkyl and -alkenyl esters of both alkyl- and aryl-substituted dithiocarbamic and hydroxydithioformic acids, (c) certain cyclic derivatives of (b), and (d) alkyl and aryl isothiocyanates. Short homologous series were selected to assess the importance of physico-chemical properties in fungitoxicity, whilst certain aryl-substituents were used on the basis of their contrasting electronic effects. 
 
 
 
Derivatives of alkoxydithioformic acids showed higher toxicity than those of N-alkyl-substituted dithiocarbamic acids, except for a series of β-(N-alkylthio-carbamoylthio)acrylic acids. The fungitoxicity of esters of alkyl-substituted dithiocarbamic or hydroxydithioformic acids showed little change on increasing the size of the alkyl substituent or ester grouping. The fungitoxicity of compounds derived from N-aryldithiocarbamic acids varied considerably with the nature of the N-substituent.