Characteristics of Submerged Flow Below Gate With Sill in Non-Prismatic Channels
The characteristics of submerged flow below vertical gate with sill upstream of horizontal diverging channel reach are analyzed based on experimental investigation. The experimental program is conducted in a laboratory flume with 10 cm wide, 31 cm deep and 3.0 m long. A diverging channel reach with fixed length and constant divergence angle is used. Polygonal sills with constant height, constant upstream slope and variable downstream slope are used under the gate. These sills are tested under wide range of similar submerged flow conditions to investigate the effect of sill slope on the flow characteristics. Also, a particular sill is tested under different heights to address the effect of sill height on the flow characteristics. Both the effects of submergence and the under-gate Froude number on the flow below the gate are discussed. Different flow regimes are considered (Supercritical, critical and subcritical flow). It is found that the presence of sill under the gate upstream of diverging channel reach has a remarkable effect on the discharge coefficient of the gate. It is noticed that the submergence ratio and the upstream head ratio are not able to explain the observed variations (or scatter of data) in the discharge coefficients. These variations or scatters are completely explained by the under-gate Froude number and the differential head ratio.
Discharge Characteristics Through Vertical Sluice Gate in a Sudden Expanding Stilling Basin
There is no doubt that, sluice gates are one of the most practical important controller and metric device. The discharge coefficient of sluice gate is an associating function of geometric and hydraulic parameters. The present study was focused on investigating experimentally the different parameters affecting the discharge below one vent sluice gate under free flow conditions. The impact of different expansion ratios and the effect of lateral sill on discharge characteristics have been investigated. Results show that, the augmentation in the expansion ratio yeve higher values for the discharge coefficient, the optimal design of lateral sill which led to high values of the discharge coefficient was also determined. Results of past studies which concerned of sluice gate discharge coefficient determinable were included for comparison purpose. The proposed statistical equations were compared with the laboratory statements and appear to be in a good agreement.
Pharmacokinetics of amikacin and chloramphenicol in the aqueous humor of rabbits
Composite data describing ocular pharmacokinetics are unreliable because of intersubject variation. To address this problem, an animal model was developed in which multiple aqueous samples from single subjects were obtained. Following direct anterior chamber or intravenous administration of amikacin or chloramphenicol, pharmacokinetic analysis of drug concentrations in the serum and anterior chamber was performed by using a nonlinear least-squares regression program. The number of anterior chamber paracenteses performed did not alter the beta elimination rates or percent penetration into the anterior chamber. The aqueous humor and peripheral-compartment terminal slopes were identical. These data indicate that complete ocular concentration-time curves can be obtained without altering antibiotic pharmacokinetics. Following direct injection into the anterior chamber, the elimination rates for both antibiotics followed a one-compartment model, whereas those following intravenous administration best fit an open, first-order, two-compartment model. Following intravenous administration, the anterior chamber elimination rate constants for both drugs were equal to that of the serum and significantly longer than that following direct injection. The elimination rates of both drugs following direct injection were similar. Systemic administration resulted in drug levels in aqueous humor that persisted longer than those following direct injection. Chloramphenicol, a lipophilic compound, gave higher mean concentrations in aqueous humor than did amikacin. Our model provides a new approach which rigorously examines ocular pharmacokinetics and provides data which suggest that for selected compounds the parenteral route of administration is preferable.