Nomenclature for factors of the HLA system, update November 2006 *
The following sequences have been submitted to the Nomenclature Committee since the October 2006 nomenclature update and, following agreed policy, have been assigned official allele designations. Full details of all sequences will be published in a forthcoming report. Below are listed the newly assigned sequences (Table 1) and confirmations of previously reported sequences (Table 2). The accession number of each sequence is given and these can be used to retrieve the sequence files from either the EMBL, GenBank or DDBJ data libraries.
A new HLA-B*07 allele, B*070503, identified in a Chinese bone marrow donor.
A novel B*070503 allele showed one nucleotide difference form the closest matching allele B*070501 at position 435 from G to A in exon 3, resulting in no amino acid substitution at codon 145K.
On the use of the Hardening Soil Small Strain model in geotechnical practice
This article highlights the importance of using advanced constitutive soil models in numerical modelling as daily geotechnical practice. In this context, the Hardening Soil (HS) model is presented as the most advanced soil model implemented in the ZSoil finite element code. The article recalls the basic features of the HS model and it explains their role in numerical simulations. The role of pre-failure non-linear behaviour of soils is also discussed. An application of the HS model is illustrated on typical geotechnical problems such as retaining wall excavation, tunnel excavation and undrained loading followed by consolidation.