A new UTD formulation for multiple cylindrical diffraction
This paper describes a new formulation of the uniform theory of diffraction (UTD) with application to multiple cylindrical structures. The new formulas present some modified UTD diffraction coefficients in cooperation with a slope diffraction term for higher accuracy in the electromagnetic modeling. The above are then combined with a simple ray tracing algorithm that takes into account multipath propagation between cylindrical structures. Comparisons with existing analytical models that employ other electromagnetic theories have shown that the new UTD solution can give very accurate results while it seems to be superior in terms of computation time and complexity. The solution can be applicable to radiowave paths which are characterized by convex structures and multipath propagation such as mountainous areas or urban areas with special rounded objects
A uniform GTD analysis of the diffraction of electromagnetic waves by a smooth convex surface
The problem of the diffraction of an arbitrary ray optical electromagnetic field by a smooth perfectly conducting convex surface is investigated. A pure ray optical solution to this problem has been developed by Keller within the framework of his geometrical theory of diffraction (GTD). However, the original GTD solution fails in the transition region adjacent to the shadow boundary where the diffracted field plays a significant role. A uniform GTD solution is developed which remains valid within the shadow boundary transition region, and which reduces to the GTD solution outside this transition region where the latter solution is valid. The construction of this uniform solution is based on an asymptotic solution obtained previously for a simpler canonical problem. The present uniform GTD solution can be conveniently and efficiently applied to many practical problems. Numerical results based on this uniform GTD solution are shown to agree very well with experiments.
Pharmacokinetics of amikacin and chloramphenicol in the aqueous humor of rabbits
Composite data describing ocular pharmacokinetics are unreliable because of intersubject variation. To address this problem, an animal model was developed in which multiple aqueous samples from single subjects were obtained. Following direct anterior chamber or intravenous administration of amikacin or chloramphenicol, pharmacokinetic analysis of drug concentrations in the serum and anterior chamber was performed by using a nonlinear least-squares regression program. The number of anterior chamber paracenteses performed did not alter the beta elimination rates or percent penetration into the anterior chamber. The aqueous humor and peripheral-compartment terminal slopes were identical. These data indicate that complete ocular concentration-time curves can be obtained without altering antibiotic pharmacokinetics. Following direct injection into the anterior chamber, the elimination rates for both antibiotics followed a one-compartment model, whereas those following intravenous administration best fit an open, first-order, two-compartment model. Following intravenous administration, the anterior chamber elimination rate constants for both drugs were equal to that of the serum and significantly longer than that following direct injection. The elimination rates of both drugs following direct injection were similar. Systemic administration resulted in drug levels in aqueous humor that persisted longer than those following direct injection. Chloramphenicol, a lipophilic compound, gave higher mean concentrations in aqueous humor than did amikacin. Our model provides a new approach which rigorously examines ocular pharmacokinetics and provides data which suggest that for selected compounds the parenteral route of administration is preferable.