Development of circumference oscillation mechanism with adjustable amplitude
According to the situation of the currently developed circumference oscillation mechanism without adjustable amplitude generally. The circular oscillation mechanism with adjustable amplitude is designed. It mainly comprises an eccentric motion mechanism and adaptive dynamic balance mechanism. The dynamic simulation and analysis is carried out on eccentric motion mechanism. The experimental results show it can achieve 0-Φ50mm adjustable amplitude and 20-350RPM adjustable oscillation frequency in the meantime, and the latter can be realized by changing eccentricity adjusting pin manually. The unbalance quality of the table can be compensated by adaptive dynamic balance mechanism in order to increase the die life. Its amplitude can be changed simply, conveniently and fast, and has the characteristics of simple and compact mechanism, rigid connection, strong bearing capacity and maintenance easily. It will be widely used in the field of biological engineering.
ADAMS kinematics simulation of series-parallel robot based on UG
On the basis of the peculiar transformation relationship inside the multi-entity modeling software,and by means of Pro/E and UG to establish the geometrical entity model of series-parallel robot.The kinematic pair of robot was defined inside the UG and the specially designated program was worked out in ADAMS.The reverse kinematic characteristics of upper and lower platforms of mechanism under specialized structural forms were dynamically simulated.The kinematics simulation result of mechanism under given conditions was reflected synthetically by the use of 3D dynamic film frame and planar curve diagram.
Energetic and Morphological Plasticity of C6 Glioma Cells Grown on 3-D Support; Effect of Transient Glutamine Deprivation
The energetic metabolism of rat C6 glioma cells has been investigated as a function of the proliferative and differentiation states under three-dimensional (3-D) growing conditions on microcarrier beads. First, the transient deprivation of glutamine from the culture medium induced a marked decrease in the growth rate and a differentiation of C6 cells through the oligodendrocytic phenotype. Second, the respiratory capacity of the C6 cells during short-term subcultures with or without glutamine continuously declined as a function of the cell density, in part due to the mitochondrial content decrease. During the transition from the early exponential to the plateau growth phase in glutamine-containing medium, the oxygen consumption rate per single cell decreased concomitantly with a decrease in the glucose consumption and lactate production rates. This phenomenon led to a sixfold decrease in the total ATP production flux, without significantly affecting the cellular ATP/ADP ratio, thus indicating that some ATP-consuming processes were simultaneously suppressed during C6 proliferation. In glutamine-free medium, the cellular ATP/ADP ratio transiently increased due to growth arrest and to a reduced ATP turnover. Moreover, the results indicated that glutamine is not an essential respiratory substrate for rat C6 glioma under short-term glutamine deprivation. Worth noting was the high contribution of the mitochondrial oxidative phosphorylation toward the total ATP synthesis (about 80%), regardless of the proliferation or the differentiation status of the C6 cells.