A therapeutic regimen for purging dieldrin from adulterated individuals
SummaryIn four feedlots 1013 steers had become contaminated by being fed over 50% of their diet as cull seed potatoes containing 0.1 to 0.2 ppm dieldrin (dry weight basis), developing residues of up to 0.76 ppm (rendered fat). These residues were in excess of federal guidelines (0.30 ppm, rendered fat), but considered non-pathological and without physiological effect. Application of a therapeutic regimen, consisting of an initial injection of testosterone propionate and vitamins A, D and E and of daily oral doses of phenobarbital (first 20 days only) and activated charcoal in a finishing ration, resulted in marked reductions in dieldrin residues within 30 days. The rate of dieldrin loss was increased six-fold and the residual half-life reduced from a reported 150 to 250 days to about 25 to 80 days. The effectiveness of individual components or combinations was not evaluated, but the rate of charcoal feeding appeared most important.
Drug effects on dieldrin storage in rat tissue
SummarySelected drugs were tested for effectiveness in reducing dieldrin retention by rats. Female rats were fed diets treated to contain 1 ppm dieldrin. The drugs were administered as feed additives or by i.p. injections. The rats were sacrificed after 10 days of treatment and abdominal adipose tissue was analyzed for dieldrin using electron capture gas chromatography.Heptabarbital (40 and 225 mg/kg rat/day), aminopyrine (75 and 350 mg/kg rat/day), tolbutamide (60 and 290 mg/kg rat/day), and phenylbutazone (90 mg/kg rat/day) were effective as feed additives in reducing tissue dieldrin. Heptabarbital was the most effective and reduced the concentration of tissue dieldrin by 80 per cent at the higher dose level. In comparison, DDT (4 mg/kg rat/day) effected a 72 per cent reduction. A contrast with DDT was also observed in trials with i.p. administration of drugs and DDT. In those trials, the duration of the DDT action was apparently greater than that of the drugs.We suggest that suitable drugs might be used to reduce insecticide accumulation in the tissues of animals and man, and for treatment of individuals after over exposure to insecticides.
Application of attribute recognition method for evaluating on sustained developmental degree of water resource systems.
Taking Ping Ba area as an example, this paper explores the method of comprehensive evaluation on sustained developmental extent of water resources systems and sets up an evaluation model by applying the attribute recognition theoretical model The result shows that it is coherence to the result of the fuzzy comprehensive evaluation method, meanwhile, this method is easy and understood, and it suit for evaluating on system quality with standardsKey words: water resources systems; attribute recognition theoretical model; fuzzy comprehensive evaluation method