Dimethamine — A new bimolecular alkaloid from Thermopsis alterniflora
SummaryFrom the epigeal part ofThermopsis alterniflora, in addition to the alkaloids found previously, argentine, argentamine, and a new alkaloid, dimethamine, which is a representative of the bimolecular series, have been isolated. The structure of 3-(3′,4′-dihydro-N-methylcytisin-5′-yl)-N-methylcytisine has been proposed for dimethamine on the basis of IR, UV, mass, and NMR spectra and also from its conversion products.
Derives de la cytisine ou derives azabicycliques condenses avec la pyridone, leur preparation et leur utilisation dans le traitement des toxicomanies
L'invention concerne des composes azabicycliques condenses avec la pyridone, de formule (I), dans laquelle R?1, R2 et R3? sont definis plus loin, leurs sels et promedicaments pharmaceutiquement acceptables, ainsi que leurs intermediaires et leurs procedes de preparation. L'invention concerne egalement des compositions et des procedes permettant d'utiliser les composes de formule (I) dans le traitement des troubles neurologiques et mentaux dus a une baisse de la fonction cholinergique, tels que la dependance a la nicotine, la choree de Huntington, la dyskinesie tardive, l'hyperkinesie, la manie, la dyslexie, la schizophrenie, l'analgesie, les troubles deficitaires de l'attention, la demence par infarctus multiples, le declin cognitif lie au vieillissement, l'epilepsie, les troubles neurologiques et mentaux dus a une baisse de la fonction cholinergique, la demence senile de type Alzheimer, la maladie de Parkinson, l'hyperactivite avec troubles deficitaires de l'attention, l'anxiete, l'obesite, la maladie de Gilles de la Tourette et la rectocolite hemorragique.
A bifunctional Cr/Yb/Tm:Ca3Ga2Ge3O12 phosphor with near-infrared long-lasting phosphorescence and upconversion luminescence.
Currently, upconversion nanocrystals and long-lasting phosphorescent particles have attracted extensive research interest for their possible applications as bioimaging probes. However, there are few reports concerning the achievement of both upconversion luminescence of lanthanide ions and long-lasting phosphorescence of transition metal ions in a sole host so far. Herein, we demonstrate a novel calcium gallium germanium garnet (Ca3Ga2Ge3O12) host where lanthanide ions such as Tm(3+)/Yb(3+) and transition metal ions such as Cr(3+) can be easily incorporated through substituting the Ca(2+) and Ga(3+) respectively. This Cr/Yb/Tm:Ca3Ga2Ge3O12 phosphor exhibits both broadband near-infrared long-lasting phosphorescence of Cr(3+) with an afterglow time of more than 7000 s and near-infrared to near-infrared upconversion luminescence of Tm(3+). Impressively, it is evidenced that the addition of Yb(3+)/Tm(3+) into Cr:Ca3Ga2Ge3O12 not only results in Tm(3+) upconversion luminescence but also greatly increases Cr(3+) afterglow time. Based on excitation/emission, three-dimensional thermoluminescence, and time-resolved luminescence spectra, the related long-lasting phosphorescence and upconversion luminescent mechanisms are systematically discussed as well.