Estimation of Fatigue Life of Long-Span Bridge by Considering Vehicle-Bridge Coupled Vibration
To estimate the fatigue life of long-span steel bridge more accurately, this paper proposes a method for estimating the fatigue life of long-span bridges by considering vehicle-bridge coupled vibration. Firstly, the universal equation of vehicle-bridge vibration is derived based on triaxial standard multi-scale model of fatigue vehicle and bridge, and relevant program for vehicle-bridge coupled vibration is programmed. Secondly, a method for estimating the fatigue life of long-span steel bridge is proposed based on fracture mechanics theories, and the analysis process is expounded in details. Finally, the method for estimating fatigue life proposed in this paper is verified by taking a double pylon cable- stayed bridge with orthotropic steel bridge deck slab as an example.
Fatigue failure of welded vertical members of a steel truss bridge
Abstract This paper describes the analysis of the collapse of a steel truss motorway bridge. The cause of the failure was fatigue crack initiation and propagation in a welded vertical member caused by insufficient weld penetration.
Clozapine derived 2,3-dihydro-1H-1,4- and 1,5-benzodiazepines with D4 receptor selectivity: synthesis and biological testing.
Novel 4-arylpiperazin-1-yl-substituted 2,3-dihydro-1H-1,4- and 1H-1,5-benzodiazepines and their aza-analogues were synthesized as debenzoclozapine derivatives for evaluation as potential D4-ligands. While Ki values of some of the title compounds came within the range of clozapine, they showed an impressively greater selectivity over other dopamine receptor subtypes, especially D2. For the most promising compounds, intrinsic activity and binding properties to serotonin 5-HT1A and 5-HT2 were also determined.