Antiviral activity of N-phosphorylated amides, thioamides, and their salts
The N-(O,O-dimethylphosphoryl)benzamide (I) was obtained according to [4]; N-(O-methylS-methylphosphoryl)acetamide (acephate) (II) was obtained according to [6], and N-(O,O-diisopropylthiophosphoryl)thiobenzamide (III) (benztriamiph) was obtained according to [7]. The synthesis of N-(O,O-diisopropylthiophosphoryl)thioacetamide (IV), the sodium salt of N-(O,O-dimethylphosphoryl)benzamide (V), and the sodium salt of N-(O,O-diethylphosphoryl)thiobenzamide (VI) is described below.
Isothiocyanates of Phosphorus Acids, N-Phosphorylated Thiocarbamates and Thioureas
Current data on the synthesis, structures, the activities, and practical applications of the isothiocyanates of tricoordinate, tetracoordinate, pentacoordinate, and hexacoordinate phosphorus acids and N-phosphorylated and N-thiophosphorylated thiocarbamates, dithiocarbamates, and thioureas are examined and surveyed. The bibliography includes 223 references.
Improvement of scopolamine-induced memory impairment by Z-ajoene in the water maze in mice
Z-ajoene, a major compound containing sulfur in oil-macerated garlic products, exhibited inhibitory effects against scopolamine-induced memory impairment in mice using the Morris water maze test. The effects of Z-ajoene were observed dose-dependently (0.25-25 mg/kg). At the highest dosage, the memory performance of mice was improved compared to normal mice. The acetylcholinesterase (AChE) activity in the brain was reduced by administration of Z-ajoene dose-dependently. However, alliin and diallyl disulfide, organosulfur compounds from garlic, did not improve memory performance nor AChE inhibitory effect. These results suggest that Z-ajoene may act on the cholinergic system and on memory impairment caused by excess activity of AChE.