Structure of the products of the metabolism of deoxypeganine and of deoxyvasicinone
The structures of the main components of the total metabolites of the anticholinesterase drug deoxypeganine (DOP) and its analog deoxyvasicinone (DOV) in the rat organism have been studied. The structures of two metabolites of DOP and DOV — 11α-hydroxydeoxyvasicinone and 2-(β-ethoxycarbonyl)ethyl-4-quinazoline — have been determined by the PMR method. On the basis of their structures and the results of measurements of the elementary compositions of ions, the fragmentation of the compounds has been elucidated. A minor component of the total metabolites has been isolated by chromato-mass spectrometry and for it the structure of 6-methoxydide-hydrovasicinone is proposed. A scheme of the metabolism of DOP and DOV has been put forward.
Bestimmung der Molekül‐ und Kristallstruktur sowie der Absolutkonfiguration von Peganin
Mittels Rontgenkristallstrukturanalyse wurde die Molekul- und Kristall-struktur sowie unter Ausnutzung der anomalen Streuung an den Chloratomen des Hydrochlorids von 2 die Absolutkonfiguration von (-)-Peganin 2 bestimmt. Danach besitzt 2R-Konfiguration. 
 
 
 
The Crystal and Molecular Structure of Peganine. Estimation of its Absolute Configuration 
 
 
 
The crystal and molecular structure of (-)-peganine hydrochloride 2 have been determined by X-ray structure analysis. Furthermore the absolute configuration of this alkaloid was deduced with the aid of the anomalous scattering at the Cl-atoms. The pyrrolidine ring of 2 has envelope conformation. 2 possesses R-configuration.
COMBINATION OF MULTIPLE ISOMORPHOUS REPLACEMENT AND ANOMALOUS DISPERSION DATA FOR PROTEIN STRUCTURE DETERMINATION. I. DETERMINATION OF HEAVY-ATOM POSITIONS IN PROTEIN DERIVATIVES.
None of these structure determinations, including the present, are up to modern standards (counter data, anisotropic refinement, refinement of hydrogen atoms) but taken as a whole they suggest that bonds significantly longer than 1-54 A occur in cyclobutane compounds. An explanation of long C-C bonds in cyclobutane rings has been given by Dunitz & Schomaker (1952) as arising from non-bonded carbon-carbon repulsion. In this compound only two of the four C-C bonds are lengthened; thus the non-bonded interaction is reduced without affecting the five-membered ring.