Improvement of Al-6061 alloys mechanical properties by controlling processing parameters
— this paper discusses the effect of casting processing parameter on the mechanical properties of Aluminum alloy 6061 companied with Al 2 O 3 and Si C P. The specimens were poured in two different mold types one of steel and the other of graphite. These two types have a wide range of cooling rate; steel has fast cooling rate whereas graphite has slow one. In order to investigate this effect, and the alloying elements participation the specimens were taken from three different positions in the mold; top, middle and bottom. The mechanical wear, hardness and microstructure examination were performed. The results showed that wear rate and hardness increase in case of specimen poured in steel mold. This increasing due to fast cooling rate which make refining of the grain size of aluminum alloys. Whereas, their mechanical properties decreased when using graphite molds. In contrast of this result, ductility is increased. This is attributed to that graphite has slow cooling rate (heat dissipate is low) which make enlargement to the grain size of aluminum alloy and the graphite is also solid lubricate playing as interactive lubricate which is main reason to decrease the wear rate.
Influences of superheat and grain structure on hot-tearing susceptibilities of AI-Cu alloy castings
AbstractAn investigation has been carried out. under controlled solidification conditions, regarding the manner in which composition, melt superheat and grain structure interact to determine the hot-tearing susceptibilities of Al- Cu alloys in the range 0·15 wt-% Cu. The results demonstrate that the influence of both superheat and grain structure relates to the way in which these variables affect the number of potential sites of crack origin. This number then has to he considered in conjunction with the mechanisms that can operate to withstand hot tearing which are themselves dependent on metal composition. Under the experimental conditions employed, cracking, as detected by measurement of electrical resistance only ever occurred in alloys containing less than 7 wt-% Cu. The actual composition range within which cracking was observed was dependent on grain structure and superheat. Increasing superheat increased the susceptibility to tearing of an alloy of fixed composition and hence the composition range ...
Atomistic insight into novel co-delivery of doxorubicin and paclitaxel using fullerene modified by dimethyl acrylamide trimethyl chitosan: A computational study

 Background: The distribution of drugs could not be controlled in the conventional drug delivery system. This has led to the development of a smart nanoparticle-based drug delivery system, known as smart drug delivery systems. In cancer research, novel biocompatible nanocarriers have received much attention for various ranges of anticancer drugs.In the current study, the effect of a novel co-polymer "dimethyl acrylamide-trimethyl chitosan" was investigated on drug delivery of doxorubicin and paclitaxel utilizing modified fullerene nanocarrier. This study was performed via molecular dynamics simulation based on acidic pH sensitivity of the cancer microenvironment. Furthermore, hydrogen bonds, diffusion coefficient, gyration radius, and drug-carrier interaction energies were investigated here. Interestingly, a simultaneous pH and temperature-sensitive system was proposed for paclitaxel and doxorubicin for a co-polymer. A pH-sensitive and temperature-sensitive copolymer was used based on trimethyl chitosan and dimethyl acrylamide, respectively. In such a dualistic approach, co-polymer makes an excellent option to have two properties in one bio-polymer. Results: The results suggest the dramatic and indisputable role of the co-polymer in the release of doxorubicin and paclitaxel in cancerous tissues, as well as an increased biocompatibility and drug uptake in a neutral state. The validation test was performed by repeated simulations of a similar article. The results are very close to those of the reference paper .Conclusions: Overall, conjugated fullerene and dimethyl acrylamide-trimethyl chitosan (DMAA-TMC) as carriers can be a good proposition for loading, delivery, and release of anti-cancer drugs based on a pH/temperature-sensitive smart drug delivery system.