Idiopathic calcinosis cutis of the penis
2 Smllli I'R. UroL'kliursl K). tVlluliir bluL' IIL'\US OI Ihf scltTii. Anh OphilmhiH'! l'»7(.; 94: fil8-2(l. 3 FuU'I I>S, i!hiit;;iviin HS, Bluciicvu.s cii'lhc ulLTLii£.'(.L'rvLX. Hum I'atlwl 19SS: If): 7*J-Sfi. 4 Hasson A. (.luticrrcz \iC. Mcinn LcI ii/. Biuo iiLni on llic prcpuLXand glaniLs penis. .S'iiiii Odiccr 1990; S: 15-19. 5 Zaiiis N. T/ii' .Wii/ in livulth itiid Disfitsc. 2m\ t'tlri. Norwalk. CV: Applcton J4 LHnge. 1990.
Idiopathic calcinosis of the scrotum: histopathologic observations of fifty-one nodules.
A 29-year-old man had a 2-year history of multiple, asymptomatic, firm, subcutaneous nodules on the scrotal skin, which sometimes discharged a chalky material. Fifty-one nodules were observed in the histopathologic examination, which revealed, in addition to the typical findings of idiopathic calcinosis of the scrotum, various forms of intact cysts: epidermal (some calcified), pilar (calcified), hybrid (calcified), and indeterminate cysts with diffusely calcified keratinous content and attenuated walls. A mixture of calcified keratinous material and inflammatory infiltrates was detected, with or without remnants of the cyst wall. These findings suggest that idiopathic calcinosis of the scrotum derives from the dystrophic calcification of cysts.
Synthesis of 2,4-dideoxy-.beta.-D-erythro-hexopyranosyl nucleosides
The synthesis of 1-(2,4-dideoxy-β-D-erythro-hexopyranosyl)thymine (12) 1 was accomplished using two different synthetic routes. It was obtained starting either from 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose or from tri-O-acetyl-D-glucal. The other modified nucleosides, with either a cytosine, guanine, or adenine moiety, were synthesized using the second reaction scheme. Deoxygenation reactions were accomplished with the (2,4-dichlorophenoxy)thiocarbonyl derivatives generated in situ