IMPLEMENTATION PROCEDURE OF AN ADVANCED SUPERVISORY AND CONTROL STRATEGY IN THE PHARMACEUTICAL INDUSTRY
Abstract This paper describes the different steps followed in implementing a temperature controller and a supervisory controller in a Supervisory Control And Data Acquisition (SCADA) system to control a 60 and 160 l reactor in a pharmaceutical factory. These reactors are used to produce the initial quantities of drugs needed to perform clinical tests. The chemical reactions involved are often changed (several times a week). The different steps of the project will be presented: • design of a new heating–cooling system, • design of the predictive and Supervisory Control Algorithm (SCA), • connection of the SCA to the SCADA system, • experimental validation according to Good Manufacturing Practice (GMP). 
This SCA has been in daily use as the standard control system for more than 2 years.
A Supervisory Control Framework for Set Point Tuning in Industrial Processes
The problem of adjusting the set point of industrial processes with unknown characteristics is studied. An agent based supervisory control system framework is proposed. Modeling agents as well as intelligent agents are included. The modeling agents derive local steady - state models around operating points of the process. These models are considered to be constructed during normal process operation using various identification techniques, each of which corresponds to a different instantiation of our system. The intelligent agents are proposed to be implemented using finite automata units. The performance of the proposed scheme is illustrated through simulation results to some well-known benchmark problems of chemical industry
Control of Batch Reactors: A Review
Because of the structural change in industry from mass production to the production of small amount of various products with high added value, batch processing has come to the fore in the nineties. In the competitive atmosphere of today, batch chemical reactors are pinpointed as where better performance can be obtained through better process control. Due to their intrinsic characteristics, however, the control of batch reactors involves complex control functionality beyond the well-established norms for continuous processes, and constitutes a challenging area. This paper reviews the progress in the field of batch reactor control. Particular developments in model based control that have been applied to batch reactors, theoretical and experimental experience reported in literature are addressed. Some main directions of current activities are highlighted and suggestions for further research are given.