Method for High Accuracy Differential Pressure Measurements Using Fluid-Filled Catheters
The advantage of measuring differential pressure using fluid-filled catheters is that the system is relatively inexpensive, but the readings are not accurate and affected by the common mode pressure (CMP) distortion. High accuracy differential pressure measurements are required in various biomedical applications, such as in fluid-dynamic test rigs, or in the cath-lab, from cardiac valves efficacy to functional assessment of arterial stenoses. We have designed and built a unique system in which the pressure difference was measured along the fluid flow inside a rigid circular tube using a fluid-filled double-lumen catheter. The differential pressure measurements were taken across two side-holes near the catheter distal tip, spaced apart by 3 cm. The goal was to overcome the CMP error, which significantly distorted the output differential pressure signal and to formulate a restoration factor. A restoration formula was developed based on simultaneous gauge pressure measurements, and was tested in several different cases. Several representative cases are presented and show that the common mode artifact was reduced by factors of 12–27. The restored pressure gradient signal was validated using direct pressure drop measurements, and showed very good agreement.
Pressure drop and arterial compliance - Two arterial parameters in one measurement.
Coronary artery pressure-drop and distensibility (compliance) are two major, seemingly unrelated, parameters in the cardiovascular clinical setting, which are indicative of coronary arteries patency and atherosclerosis severity. While pressure drop is related to flow, and therefore serves as a functional indicator of a stenosis severity, the arterial distensibility is indicative of the arterial stiffness, and hence the arterial wall composition. In the present study, we hypothesized that local pressure drops are dependent on the arterial distensibility, and hence can provide information on both indices. The clinical significance is that a single measurement of pressure drop could potentially provide both functional and bio-mechanical metrics of lesions, and thus assist in real-time decision making prior to stenting. The goal of the current study was to set the basis for understanding this relationship, and define the accuracy and sensitivity required from the pressure measurement system. The investigation was performed using numerical fluid-structure interaction (FSI) simulations, validated experimentally using our high accuracy differential pressure measurement system. Simplified silicone mock coronary arteries with zero to intermediate size stenoses were used, and various combinations of arterial distensibility, diameter, and flow rate were simulated. Results of hyperemic flow cases were also compared to fractional flow reserve (FFR). The results indicate the potential clinical superiority of a high accuracy pressure drop-based parameter over FFR, by: (i) being more lesion-specific, (ii) the possibility to circumvent the FFR dependency on pharmacologically-induced hyperemia, and, (iii) by providing both functional and biomechanical lesion-specific information.
Parboiled rice effluent: A wastewater niche for microalgae and cyanobacteria with growth coupled to comprehensive remediation and phosphorus biofertilization
Abstract The potential of microalgae and cyanobacteria for bioremediation of wastewater by nutrient uptake combined with simultaneous biomass production is a well recognized perception of today's world. The present study illustrates the treatment of a highly polluted wastewater generated during parboiling of paddy in rice mill industries, widely operational in developing countries where rice is the staple food crop, with the help of microalgal and cyanobacterial isolates capable of growing at high rates in parboiled rice mill effluent (RME). This endeavor leads to comprehensive bioremediation of the said effluent and subsequent use of the harvested biomass as slow release phosphorus biofertilizers and the treated effluent for crop irrigation. The RME-acclimatized algal consortium demonstrated highest growth in terms of fresh weight and greatest remediation efficiency at the end of 36 days' treatment of RME, with 93.9% phosphorus and 100% ammonia-nitrogen removal, 98.7%, 91.6% and 93.5% reduction in biological oxygen demand, chemical oxygen demand and total dissolved solid, respectively, and an increment of 186 ± 0.3 mg L − 1 dissolved oxygen, bringing down the pollutants level well below the discharge limits suggested by Central Pollution Control Board, India. Additionally, microalgae in the consortium aggregated in clumps spontaneously in presence of the filaments of Phormidium sp. facilitating easy harvest. The RME-acclimatized algal consortium demonstrated highest accumulation of polyphosphate (poly-P) (0.76 ± 0.01% of dry weight) as well as highest release of phosphorus in non-sterile soil emphasizing the essential role of soil phosphorus solubilizing organisms to leach soluble phosphorus from the insoluble poly-P present in the biomass. The rice seedlings watered with treated RME also showed improved growth effect on shoot height and leaf width. The study results establish the suitability of RME as an excellent growth media for microalgae and cyanobacteria.