Focusing System With Permanent Magnets for Klystrons
Applying permanent magnet technology to beam focusing in klystrons can reduce power consumption and increase reliability. These features benefit a variety of applications especially for large facilities that use a large number of klystrons such as the International Linear Collider. The low magnetic field needed for the purpose allows us to use inexpensive ferrite magnets instead of rare earth magnets. In order to evaluate the feasibility of such a focusing system with ferrite magnets, a test model for 750 kW L-band klystron was constructed. As a result of the power test, we attained 94% of the output power compared to an electromagnet.
DESIGN CONSIDERATION TO PPM KLYSTRONS FOR INDUSTRIAL LINAC
Toshiba has been developing the C-band and X-band Periodic Permanent Magnet (PPM) focused klystron in collaboration with KEK and manufactured prototypes for the JLC project. [1] The PPM klystron has an advantage to enhance the total efficiency as a result of eliminating the electric power for the focusing magnet. From experience on the development the PPM focused klystrons for the JLC project, we plan to apply the PPM focused klystron to the medical and industrial linac. The periodic magnet focusing scheme has some technical difficulties such as stop band voltage. To design the PPM klystron for the medical and industrial linac, it is necessary to give heed to electron beam instability; so that the tube parameters of the PPM focused klystrons have some constraints. The size of the accelerator system is substantially reduced if a PPM focused klystron is used. The majority of medical and industrial linacs use frequencies of S-band range. We discuss the availability of the S-band PPM focused klystron in this paper.
Nuclear sphingolipid metabolism.
Nuclear lipid metabolism is implicated in various processes, including transcription, splicing, and DNA repair. Sphingolipids play roles in numerous cellular functions, and an emerging body of literature has identified roles for these lipid mediators in distinct nuclear processes. Different sphingolipid species are localized in various subnuclear domains, including chromatin, the nuclear matrix, and the nuclear envelope, where sphingolipids exert specific regulatory and structural functions. Sphingomyelin, the most abundant nuclear sphingolipid, plays both structural and regulatory roles in chromatin assembly and dynamics in addition to being an integral component of the nuclear matrix. Sphingosine-1-phosphate modulates histone acetylation, sphingosine is a ligand for steroidogenic factor 1, and nuclear accumulation of ceramide has been implicated in apoptosis. Finally, nuclear membrane-associated ganglioside GM1 plays a pivotal role in Ca(2+) homeostasis. This review highlights research on the factors that control nuclear sphingolipid metabolism and summarizes the roles of these lipids in various nuclear processes.