Idiopathic calcinosis cutis of the penis
2 Smllli I'R. UroL'kliursl K). tVlluliir bluL' IIL'\US OI Ihf scltTii. Anh OphilmhiH'! l'»7(.; 94: fil8-2(l. 3 FuU'I I>S, i!hiit;;iviin HS, Bluciicvu.s cii'lhc ulLTLii£.'(.L'rvLX. Hum I'atlwl 19SS: If): 7*J-Sfi. 4 Hasson A. (.luticrrcz \iC. Mcinn LcI ii/. Biuo iiLni on llic prcpuLXand glaniLs penis. .S'iiiii Odiccr 1990; S: 15-19. 5 Zaiiis N. T/ii' .Wii/ in livulth itiid Disfitsc. 2m\ t'tlri. Norwalk. CV: Applcton J4 LHnge. 1990.
Calcification in the penis.
The occurrence of calcification or ossification in the human penis is relatively rare. In the majority of cases the presence of such calcium or bone is the result of local trauma or plastic induration of the penis (Peyronie's disease). Rarely a so-called “os penis” has been reported in the human. Very few radiological demonstrations of penile calcification or ossification are to be found in the literature. In view of this, the following case may be worthy of record. A 53-year-old African male, J.M., was admitted to hospital in September, 1959. He complained of intermittent attacks of pain in both hip joints and stiffness of the back of two years' duration. During the course of investigation a radiograph of the pelvis was taken and this demonstrated the presence of calcification within the penis (Fig. 2). Further interrogation of the patient revealed that he had been the unfortunate recipient of a kick on the penis approximately two years prior to his present admission to hospital; the organ was not swolle...
Thorium-induced Anatomical and Histopathological Changes in Liver of Swiss Mice
ObjectivePresent study is aimed to investigate the anatomical and histopathological changes in liver tissues of Swiss albino male mice, one month after intravenous administration of thorium (232Th; 4 and 40 mg/kg).MethodsSynchrotron X-ray micro-CT imaging, CD31 immuno-cytochemistry, hematoxylin & eosin staining and Periodic acid-Schiff staining were performed to study changes in liver anatomy, blood vessels/capillaries, histology and glycogen content of liver, respectively.ResultsSynchrotron X-ray micro-CT imaging of liver showed loss of blood vessels in mice treated with thorium (4 mg/kg), which was more prominent at higher dose of thorium (40 mg/kg). These thorium-induced changes in liver were correlated with the decrease in CD31 positive cells and loss of tissue architecture. A dose-dependent increase in glycogen content was also observed in the liver of thorium-treated mice.ConclusionOur results provide novel insight about the effects of thorium on liver, which may have significant implications in understanding the mechanism of thorium thorium-induced hepatotoxicity.