Effect of Synchrotron Radiation in the Proposed 4-GeV Argonne Microtron
Synchrotron radiation in the sector magnets of the 4 GeV microtron designed at the Argonne National Laboratory produces a small but noticeable distortion of the closed orbits of the system and a very significant growth of the horizontal and longitudinal phase space emittances. Because of the small apertures in the three 25 meter linacs, it is important that the expected growth of the beam be calculated as accurately as possible. The dynamical problem has been solved using a computer program which follows the motions of individual electrons in the four dimensional horizontal and longitudinal phase space as they are accelerated in the system. In this paper the authors call attention to the fact that there are 3 long 28 m linac sections separated by sector magnets from 3 dispersion sections where the orbits for different energies are separated. The interaction of the linac rf systems with the synchrotron energy loss in the sector magnets produces different orbit effects in the downstream and upstream linac sector magnets. The average synchrotron radiation energy loss per sector magnet is given.
Transverse Beam Containment in the ANL 4-GeV Microtron
Optical systems have been designed to contain the electrons during the acceleration from 0.185-4.0 GeV. These systems are located in the dispersive straight sectionX and maintain a matched dispersion free beam with ß* = 15.0 m in the linac centers, and transverse beam waists in the centers of the dispersive straight sections. A thin-lens code has been developed to design the multi-energy system. Three versions of the focussing systems have been evolved: (i) Two quadrupole triplets for E ¿ 1.62 GeV; (ii) A single triplet for 1.655 ¿ E 2.215 GeV, and (iii) A pentaquad system for E ¿ 2.250 GeV. For case (i) we step the exit edges for the 60° bending magnets so as to simulate a zero degree edge - this reduces vertical defocussing effects to an acceptable value. At the higher energies the exit edge angles are -60°. The entrance angles are 15° on the linac sides of the dipoles. Energy behavior of the Twiss parameters and quadrupole strengths are presented.
Electrophysiological evidence that a subset of midbrain dopamine neurons integrate the reward signal induced by electrical stimulation of the posterior mesencephalon
This study was aimed at determining whether midbrain dopamine (DA) neurons are trans-synaptically activated by rewarding electrical stimulation applied near the midline in the posterior mesencephalon (PM), and in the affirmative, whether the increase in firing was proportional to the rewarding effectiveness of the stimulation. Experiments were performed on male Long-Evans rats trained to lever press to obtain 400 ms trains of cathodal rectangular pulses. Following the training period, curves relating the rates of responding to the stimulation frequencies were determined at two current intensities and reward thresholds were calculated for each animal. Each animal was then anesthetized with urethane (1.2 g/kg, i.p.) and firing rate of DA neurons were recorded before, during, and after each of 50 trains (1 train/3 s) of stimulation to the PM using stimulation parameters that either sustained near threshold responding (rewarding), or failed to sustain responding (non-rewarding), in the behavioral tests. A total of 24 DA cells were recorded from 13 behaviorally trained animals, and of these, 17 (71%) responded to rewarding stimulation by an increase in firing, five (21%) were unresponsive and two (8%) were inhibited. In 12 of the 17 cells that were activated, the increase in firing was proportional to the rewarding effectiveness of the stimulation rather than the total strength of the stimulation. These results provide evidence that a subset of midbrain DA neurons are trans-synaptically activated by rewarding PM stimulation and constitute a second, or subsequent, stage of the reward-relevant pathway that integrates the PM reward signal.