Use and abuse of psoralens.
The psoralens 1 are furocoumarins to which most people in the United States have been exposed. Celery contains psoralen. Oil of bergamot, widely used in perfumes, contains 5-methoxypsoralen. Thus, there are few persons who have not ingested psoralen and probably no adult woman who has not applied a psoralen to her skin. Plants containing psoralen have been used to produce pigmentation for at least 3,000 years. Recently, oil of bergamot has been used for this purpose. Scientific investigation of the psoralens began when Kuske 2 and, later, Fahmy and his group 3 isolated the active chemicals from a variety of plants. Many physicians in different countries began to study these compounds. Lerner, Denton, and Fitzpatrick 4 and Kelly and Pinkus 5 initiated clinical evaluation in the United States. The chemical alterations in the psoralesn which occur after oral ingestion or topical application to the skin are not known. Exposure of
Simplification of local therapy of psoriasis with 8‐methoxypsoralen
Local 8‐methoxypsoralen black‐light treatment was carried out on sixty‐two patients. For the first time, oil was employed as a preparation base in order to increase the transparency and so the effectiveness of irradiation. Also the need for a descaling pretreatment was avoided. In investigations still being carried out, 27.5% patients showed very good improvement, 48.4% good and 24.2% unsatisfactory results of treatment. In many cases, less than fifteen irradiation sessions were necessary for clinical healing. However, to obtain a uniform pigmentation, additional irradiation proved necessary.
Thermodynamics on the Carbochlorination of Titanium-bearing Ores
The equilibrium compositions of the multi-component, multi-phase and multi-reaction system of carbochlorination of titanium-bearing ores are calculated with HSC, a computational chemistry software. The thermodynamic equilibrium calculation of the reaction system shows that a complete conversion of titanium-bearing ores is feasible at a temperature near 200oC. At temperatures ranging from 800 to 1600oC, the products of the reaction system are all in gaseous phase. Thermodynamic analysis accords with the industrial practice. The simulated results provide reasonable scientific basis for improving suitable technological conditions of the carbochlorination reduction.