Measurement and evaluation of the irradiation test parameters for a specimen in a HANARO material irradiation capsule
A material capsule system has been developed for irradiation tests of nuclear materials in the core region of the High-flux Advanced Neutron Application Reactor (HANARO) and has been actively utilized for the various material irradiation tests requested by numerous users. For an irradiation test in the reactor, nuclear characteristics and irradiation temperature of the capsule parts are basically necessary for the safety analysis of the capsule and capsule detail design. The irradiation temperature and neutron fluence of the specimens are key parameters required by a user to analyze any neutron irradiation damage effects. Based on a basic design of a capsule, the reactivity effect, neutron flux/fluence, and gamma heating of specimens are calculated by the MCNP code. To compare the calculated neutron fluence of the specimens, thermal and fast fluence monitors (F/Ms) are installed in a capsule. After an irradiation, the F/Ms are dismantled and analyzed to obtain a neutron spectrum. The obtained fast neutrons (E>1.0MeV) by using the SANDII code are located within about a 20% error range of the theoretical values calculated by the MCNP code. The irradiation temperature of the specimens is analyzed preliminary by using the GENGTC or ANSYS codes based on the basic design of a capsule and gamma heating. During an irradiation test, the temperatures of the specimens in a capsule are measured and monitored by thermocouples. The DPA (Displacement Per Atom) and activation of the irradiated specimens are also evaluated by using the SPECTOR and ORIGEN2 codes, respectively, at HANARO.
Study on the Effects of Liquid Thermal Media on the Irradiation Capsule of High-Temperature Materials
Irradiation tests of materials at HANARO have usually been conducted using a standard capsule at temperatures of about 300°C for irradiation of materials used at PWR. Thus, the standard capsule uses aluminum as the specimen holder, which acts to dissipate the thermal energy. Future nuclear systems such as a VHTR and SFR require the irradiation tests at a relatively high temperature. As an alternative to aluminum which has been used as the thermal media in a standard material capsule, the characteristics of liquid metals such as NaK and LBE are reviewed. The temperatures of the capsule are affected by the variation of parameters such as the gap and wall thickness of the container. In particular, the external gap is most important in determining the temperature of the specimen. LBE raises the temperature of the specimen higher than NaK at the same configuration of the capsule. Thus, LBE can lessen the gap of the parts and reduce the vibration for a stable long-term test in reactor.
High-Performance Liquid Chromatographic (HPLC) and HPLC-Mass Spectrometric (MS) Analysis of the Degradation of the Luteinizing Hormone-Releasing Hormone (LH-RH) Antagonist RS-26306 in Aqueous Solution
The kinetics of the degradation of an LH-RH antagonist, RS-26306,1, in aqueous solution from pH 1 to pH 11 were studied by reverse-phase HPLC. The pH–rate profiles at 50, 60, and 80°C were U-shaped with the rate law of kobs = kHaH + kw + kOHaOH. The predicted 25°C shelf life at the pH of maximum stability, pH ∼5, is greater than 10 years. The products from the degradation were analyzed by HPLC-MS using thermospray ionization. Below pH 3, the primary product, 2, forms from the acid-catalyzed deamidation of the C-terminal amide. Above pH 7, epimerization of the individual amino acids is the principal reaction. Between pH 4 and pH 6, intramolecular serine-catalyzed peptide hydrolysis becomes important, yielding a tripeptide, 3, and a heptapeptide, 4. At the pH of maximum stability all three pathways for degradation are observed.