A novel approach to the synthesis of cytotoxic C2-C3 unsaturated pyrrolo[2,1-c]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents.
A concise synthesis of three novel C2-C3 unsaturated pyrrolo[2,1-c][1,4]benzodiazepine analogues (18-20) containing conjugated acrylyl C2-substituents is reported that utilises Heck coupling to install the C2-acrylyl side chains. These analogues possess significant cytotoxicity according to the NCI 60-cell line screen with 18 surpassing anthramycin (1) in potency.
Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-Troc protection and Suzuki coupling.
Novel C7-aryl pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) have been synthesized via Suzuki coupling between a 7-Iodo N10-Troc-protected PBD carbinolamine and commercially available boronic acids.
Exploring interculturally competent teaching in social sciences classrooms
Abstract This paper explores a grounded research-based framework for intercultural competence and discusses the implications of interculturally competent teaching in the classroom and beyond. Given the importance of teachers being interculturally competent in today’s diverse classrooms, a number of questions, based on the framework, are presented, which guide teachers in reflecting upon their own teaching practice and the ways in which they integrate aspects of intercultural competence into their classrooms. The paper also provides some examples from the USA of ways in which intercultural competence development is being addressed in teacher training.