Secrets Between Selves and The Exchange of Desires: Mirror-Stage Politics and Self-Reflecting Wishes within Conrad's "The Secret Sharer" and Under Western Eyes
Thesis written by a student in the UNT Honors College discussing author Joseph Conrad's work in relation to self-realization, self-awareness, and the loss of self. Includes psychoanalytic theories, especially those of Jacques Lacan.
Essays on Conrad
Foreword: Frank Kermode 1. Joseph Conrad: alienation and commitment 2. Almayer's Folly: introduction 3. Conrad criticism and The Nigger of the 'Narcissus' 4. Conrad's Heart of Darkness and the critics 5. Comedy and humour in Typhoon 6. Political and social background of The Secret Agent 7. The Secret Sharer: introduction 8. Conrad, James and Chance 9. Story and idea in The Shadow-Line 10. The decline of the decline: notes on Conrad's reputation 11. Around Conrad's grave 12. 'The Bridge over the River Kwai' as myth.
Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform
This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, the effectiveness of 20 dicarboxylic acids to generate a specific cross-linked hydrogel capable of supporting different amounts of γ-cyclodextrin (γ-CD) was evaluated. According to the interaction energies calculated with the in-silico studies, the hydrogel made from PVA cross-linked with succinic acids (SA) was shown to be the best candidate for containing γ-CD. Later, molecular dynamics simulation studies were performed in order to evaluate the intermolecular interactions between PDN and three cross-linked hydrogel formulations with different proportions of γ-CD (2.44%, 4.76% and 9.1%). These three cross-linked hydrogels were synthesized and characterized. The loading and the subsequent release of PDN from the hydrogels were investigated. The in-silico and experimental results showed that the interaction between PDN and γ-CDHSA was mainly produced with the γ-CDs linked to the hydrogels. Thus, the unique structures and properties of γ-CDHSA demonstrated an interesting multiphasic profile that could be utilized as a promising drug carrier for controlled, sustained and localized release of PDN.