Improvement in the method for the preparation of N-(3,4-dimethoxyphenylethyl)-3′,4′-dimethoxyphenylacetamide
The synthesis of I was first described in 1909 [i]. At present several methods are known for the preparation of this compound, starting from 3,4-dimethoxyphenylethylamine (If) and 3,4-dimethoxyphenylacetic acid (III) or its acid chloride (IV) [2-4]. The use of IV makes it possible to obtain I in a yield of up to 95% [5, 6], but this method cannot be used industrially because of considerable complications of the industrial process.
Practical preparation of coralyne chloride.
Abstract Coralyne chloride was prepared by a convenient process which can be adapted to large-scale synthesis of this antileukemic alkaloid.
Differences in the length of initial hospital stay in very preterm infants
Aim: To investigate the effect of maternal, infant and birth hospital district related factors on the length of initial hospital stay in very preterm infants. In addition, rehospitalization rate within the first year from the initial discharge was studied.