Love Thy Neighbor: The Tampere Convention as Global Legislation
The Internet, 24-hour news sources, and a host of other telecommunications advances have allowed global citizens to become instantaneously informed. With the privilege of real-time updates and acute awareness of the world’s events comes the responsibility of being more than a passive observer. Specifically, this Note focuses on the technological improvements in communication during natural disasters—improvements that can be used to assist and aid the victims of catastrophes. In the aftermath of a natural disaster, the country affected is rarely able to provide for its citizens; tsunamis, hurricanes, tornadoes, and earthquakes can (and often do) cripple an entire nation. This Note argues that a global responsibility exists to step in and help an affected country when it cannot help itself.  For instance, the 1998 Tampere Convention on the Provision of Telecommunication Resources for Disaster Mitigation and Relief Operations is the first global attempt to concretely define relief efforts by other nations, without demanding compliance or a singular rigid course of action. Instead, the Convention creates a flexible framework that each member nation can adapt to its own telecommunications infrastructure. In legislating on a global scale, the Convention acknowledges the interconnectedness of the world’s people, and presents ways in which global citizens can improve one another’s existence in the hours following a natural disaster—arguably when they need help most.
Reprint On Radio-Frequency Spectrum Management
This article review lessons learned from the uses of radio-frequency (RF) spectrum at national and international scales. Its main purpose is to stimulate debate on how to allow new wireless systems to operate, and to reduce the chronic apparent shortage of RF spectrum. The article aims at a better understanding of the mechanisms behind spectrum management and their pertinence to the public interest. The main contributions if the article are: • Considering RF spectrum management as a construct that structures radio services and, at the same time, distributes wealth and power; • Highlighting major doctrines of RF spectrum manage-
Influence of inducers and inhibitors on the metabolism in vitro and neurochemical effects in vivo of MDMA.
(S)-(+)- and (R)-(-)-3,4-methylenedioxymethamphetamine (MDMA) were metabolized in vitro by rat liver microsomes via N-demethylation to 3,4-methylenedioxyamphetamine (MDA). Whereas no difference was found in the biotransformation of the two enantiomers in the male rat or in the phenobarbital (PB) treated animals of either sex, more than twice as much MDA was formed from (S)-(+)- than from (R)-(-)-MDMA in the untreated female rat. Although 3-methylcholanthrene (3MC) pretreated rat liver microsomes were less active than those from the untreated rats of the same sex, they formed more MDA from (+)- than from (-)-MDMA. The enantioselective metabolism thus appears to be associated with the relative abundance of individual cytochrome P-450 isozymes. (S)-(+)- and (R)-(-)-MDMA.HCl (20 mg/kg) were about equipotent in depleting serotonin (5-HT) levels in the frontal cortex at 3 hrs and 1 wk following oral administration to female rats. Pretreatment of rats with SKF-525A attenuated and that with PB enhanced the 5-HT depleting potential of either isomer at 3 hrs. The 5-HT depleting potency of (+)-MDMA was significantly greater than that of its (-)-antipode at 3 hr in PB pretreated, but not in SKF-525A pretreated animals. The results suggest that the neurochemical effects of MDMA are caused by the formation of an active metabolite in vivo, and since both enantiomers were N-demethylated in vitro to approximately the same extent by PB pretreated rat liver microsomes, the active metabolite may be other than MDA.