Retraction: Glyphosate Use Predicts ADHD Hospital Discharges in the Healthcare Cost and Utilization Project Net (HCUPnet): A Two-Way Fixed-Effects Analysis
The publisher wishes to retract this paper because it was published in error. This paper was editorially rejected following peer review and consultation with the Editorial Board. Unfortunately , the production process was erroneously completed on this paper resulting in publication , and the publisher apologizes for this mistake. open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Glyphosate Use Predicts Healthcare Utilizationfor ADHD in the Healthcare Cost and UtilizationProject net (HCUPnet):A Two-Way Fixed-Effects Analysis
There has been considerable international study on the etiology of rising mental disorders, such as ADHD, in human populations. As glyphosate is the most commonly used herbicide in the world, we sought to test the hypothesis that glyphosate use in agriculture may be a contributing environmental factor to the increase in healthcare utilization among individuals with diagnosed ADHD. State estimates for glyphosate use and nitrogen fertilizer use were obtained from the USGS. We queried the Healthcare Cost and Utilization Project net (HCUPNET) for state-level hospitalization discharge diagnosis data on all patients for all-listed ADHD cases from 2007 to 2010. The least squares dummy variable (LSDV) method and within the method using two-way fixed effects was used to elucidate the relationship between glyphosate use and all-listed ADHD hospital discharge diagnoses. A 1-kg increase in glyphosate use in one year positively predicts state-level all-listed ADHD discharge diagnoses the following year (coefficient = 5.54E-08, p<.01). A study of the effects of urbanization on the relationship between glyphosate use and ADHD indicates that the relationship is marginally significantly positive in urban U.S. counties (p<.025). Furthermore, total glyphosate use is strongly associated with total farm use of nitrogen fertilizers from 1992 to 2006 (p<.001). Glyphosate use is a significant predictor of state healthcare utilization for ADHD, with the effect concentrated in urban U.S. counties. We draw upon the econometric results to propose unique and exploratory mechanisms, borrowing principles from soil and atmospheric sciences, for how glyphosate-based herbicides may be contributing to the rise of ADHD in all populations.
Attention deficit hyperactivity disorder among children exposed to secondhand smoke: a logistic regression analysis of secondary data.
BACKGROUND
A growing body of literature examines the association of postnatal secondhand smoke exposure with attention deficit hyperactivity disorder (ADHD) in children, but the findings are mixed.


OBJECTIVE
We compare prevalence of ADHD in children aged 4-15 years who were exposed to postnatal secondhand smoke with prevalence in those who were not exposed, and examine the association of postnatal secondhand smoke exposure with ADHD using both reported and cotinine-measured secondhand smoke exposure.


DESIGN AND SETTING
We analyze secondary data from the 1999-2004 U.S. National Health and Nutrition Examination Surveys.


PARTICIPANTS
Analyses using reported secondhand smoke exposure and cotinine-measured exposure included 6283 and 6033 children aged 4-15 respectively, including 419 and 404 children who either had a reported physician diagnosis of ADHD or were taking stimulant medications.


METHODS
The association of secondhand smoke exposure with ADHD was examined by two multiple logistic regression models that differ in the secondhand smoke measurement used.


RESULTS
After controlling for maternal smoking during pregnancy, gender, age, race/ethnicity, preschool attendance, health insurance coverage, and exposure to lead, children with reported secondhand smoke exposure at home were more likely to have ADHD (adjusted odds ratio=1.5, 95% confidence interval: 1.1-2.0) than those who were not exposed. After controlling for these covariates, children with detectable cotinine levels were more likely to have ADHD (adjusted odds ratio=1.8, 95% confidence interval: 1.3-2.5) than those with non-detectable levels.


CONCLUSIONS
Our findings suggest that secondhand smoke exposure in children is strongly associated with ADHD independent of other risk factors and this association is robust using both measurements of secondhand smoke exposure. Further research is needed to understand the mechanism underlying this association. Nurses and other healthcare professionals can play an important role in encouraging parents to quit smoking to reduce children's exposure to secondhand smoke and their risk of ADHD.