Medicinal Properties of Tinospora Cordifolia (Guduchi)
Tinospora cordifolia is one of the most important medicinal plant commonly known as Giloy belonging to menispermaceae family is a deciduous climbing shrub described known for its immense application in the treatment of various diseases such as jaundice, fever, diabetes, and skin diseases etc.The chemical constituents of this shrub belong to different classes such as alkaloid, lactones, steroids, phenolics, aliphatic compound, glycosides and polyscharide compounds having medical importance.
A furanoid diterpene glucoside from Tinospora cordifolia
Abstract A novel furanoid diterpene glucoside with the molecular formula C 26 H 34 O 11 was isolated from the stems of Tinospora cordifolia . Its complete structure was determined by spectroscopic and chemical studies along with the comparison of the spectral data with the related furanoid diterpene glucosides.
Effects of the adjuvants SGP and Quil A on the induction of experimental autoimmune thyroiditis in mice.
In the present study, two adjuvants, SGP and Quil A, were assessed for their ability to induce experimental autoimmune thyroiditis (EAT) in mice. SGP (a synthetic copolymer of starch, acrylamide, and sodium acrylate) and Quil A (a plant saponin) were compared with lipopolysaccharide (LPS) and complete Freund's adjuvant (CFA) given together with mouse thyroglobulin (MTg) for their ability to induce EAT in CBA/J mice. Immunization with MTg and LPS, MTg and CFA, or MTg with SGP was effective in inducing anti-MTg antibodies and histologic EAT, while MTg with Quil A was ineffective in inducing either anti-MTg antibodies or EAT. MTg with LPS was able to prime mice for the development of an in vitro spleen cell proliferative response to MTg while MTg with SGP or with Quil A was unable to prime spleen cells to proliferate detectably in response to MTg. MTg with LPS given in vivo primes CBA/J spleen cells for further activation by in vitro culture with MTg to transfer EAT to naive CBA/J recipients. MTg with SGP was also effective in priming CBA/J spleen cells for in vitro activation and transfer of EAT while MTg with Quil A was ineffective. The effective adjuvant activity of SGP and its lack of toxicity relative to LPS should make it a useful agent for further studies in murine models of EAT.