Chemistry of Kupipakwa Rasayanas – A Review
Kupipakwa Rasayanas are very popular and commonly prescribed preparations among the Ayurvedic physicians, and are looked upon as panacea. These are prepared in a specially designed glass bottle by gradual heating immersion in sand bath (Valuka Yantra). Particular chemical processes are involved in these preparations which also bear testimony to the great chemical knowledge prevailing in ancient India. In the present review, the probable chemistry of Kupipakwa Rasayanas has been discussed.
Clinical Evaluation of Siddha Drug Gowri Chinthamani Chendooram in the Management of Osteoarthritis
The present study was carried out to investigate the efficacy and safety of Siddha drug Gowri Chinthamani Chendooram (GCC) in the treatment of osteoarthritis (Keel Vayu). The raw drugs for the preparation of GCC were obtained and authenticated by the Gunapadam experts. The drugs were purified according to the specification given in the Siddha classical literature “Agasthiar Vaidhya Kaviyam – 1500”. The purified raw drugs were then prepared under the capsule heating process. Fifty patients of either sex were selected for clinical trials and were given a dose of 100 – 200 mg thrice a day with Thirikadugu Choornam and sufficient honey after meals. The duration of the treatment depended on the severity from 30 – 60 days. The clinical efficacy with respect to symptoms and grade of movement restriction were assessed prior to and after the treatment. Majority of the patients showed a significant response in ways of remarkable reduction in various symptoms and joint swelling. None of the patients showed any adverse effects. The result of the present study suggested that the usefulness of GCC in patients with osteoarthritis. Keywords––Osteoarthritis, Gowri Chinthamani Chendooram, Keel vayu, joint swelling, Siddha.
Synthesis of Dihydrostreptobiosamine
The isopropylidene derivative (4) of benzyl dihydrostreptoside and 3,4,6-tri-O-acetyl-2-amino-N-anisylidene-2-deoxy-α-L-glucopyranosyl bromide (7) were prepared, and they were coupled by a modified Koenigs-Knorr condensation. After hydrolysis of the N-ankylidene group of the product, N-methoxycarbonylation followed by N-methylation was accomplished to afford the fully protected derivative (9) of dihydrostreptobiosamine, which was, after deblocking, led to benzyl dihydrostreptobiosaminide and dihydrostreptobiosamine.