Design, Synthesis and Bioactivities of Novel Dichloro-Allyloxy-Phenol-Containing Pyrazole Oxime Derivatives
In this study, in order to find novel biologically active pyrazole oxime compounds, a number of dichloro-allyloxy-phenol-containing pyrazole oximes were designed and synthesized according to the method of active group combination. All of the target compounds were confirmed by 1H-NMR, 13C-NMR and elemental analysis. In addition, bioassays showed that all of the newly synthesized compounds had no acaricidal activity against Tetranychus cinnabarinus and low insecticidal activity against Aphis craccivora at tested concentrations. However, most of them displayed excellent insecticidal activity against Oriental armyworm at a concentration of 500 μg/mL, and some designed compounds still exhibited potent insecticidal activity against Oriental armyworm even at the dose of 20 μg/mL, especially compounds 7f, 7n and 7p had 100%, 90% and 90% inhibition rates, respectively, which were comparable to that of the control pyridalyl.
Synthesis and Insecticidal Activity of Sulfinic Esters Containing Dichloropropene
In search for new insecticides with high activity, broad-spectrum, low toxicity, favorable safety profile and no cross resistance to commercialized insecticides, eleven novel sulfinic esters containing dichloropropene were designed and synthesized from p-dihydroxybenzene in multiple steps. The structures of title compounds were identified by 1 H NMR, 13 C NMR spectra and elemental analysis. The preliminary bioassays indicated that some of the target compounds showed good insecticidal activity against Plutella xylostella L. 3-(2,6-Dichloro-4-(3,3-dichloroallyloxy)phenoxyl)propyl n-hexyl sulfurous ester (7h) showed 80% mortality against Plutella xylostella L. at 10 mg/L, better than pyridaly. Keywords dichloropropene; sulfinic esters; synthesis; insecticidal activity; Plutella xylostella L.
Synthesis and insecticidal activity of novel dihydropyrrole derivatives with N-sulfanyl, sulfinyl, and sulfonyl moieties.
This paper reports the synthesis and insecticidal activity of a new type of dihydropyrrole derivatives with sulfur moieties such as sulfanyl, sulfinyl, and sulfonyl groups at the 1-position. These derivatives exhibited high insecticidal potency against Nilaparvata lugens and Nephotettix cincticeps. Investigation of the structure-activity relationships revealed that the alkoxycarbonyloxy groups at the 4-position tended to increase the systemic insecticidal activity.