Enflurane (Ethrane, compound 347) in man *
Enflurane (2 chloro-1, 1,2-trifluoroethyl difluoro methyl ether) (CHFrOCFrCHFC1) is a halogenated liquid developed by Ross Terrell with the trade name Ethrane1’2. Enflurane has a pleasant, non-irritating smell, is volatile, colourless, non-flammable, stable with soda-lime, and unaffected by metals, light, moisture, heat and oxygen. It is non-explosive in anaesthetic concentrations when mixed with oxygen, air or nitrous oxide. Table 1 shows its physical and chemical characteristics. Virtue et al. 3 confirmed the anaesthetic properties of enflurane in dogs. They found that the agent was incompatible with the use of adrenaline and discovered some evidence of neuromuscular excitation under deep anaesthesia. McDowell and his colleagues4 also used enflurane on dogs. They produced some cardiac and respiratory depression and reported that it
Clinical and Laboratory Evaluation of a New Inhalation Agent: Compound 347 (CHF2-O-CF2-CHF Cl)
Compound 347 (CHF2-O-CF2-CHFCl), a new non-explosive fluorinated ether, was administered with nitrous oxide–oxygen to 100 patients for major elective abdominal operations. This agent provided rapid, pleasant induction and emergence and adequate hypnosis, analgesia and muscular relaxation, with minimal alterations in the vital signs. Circulatory dynamics and cardiac rhythm remained relatively stable. Patient acceptance was excellent. Comprehensive laboratory studies of the blood showed no change in acid-base balance, serum sodium and chloride, a slight decrease of serum potassium and inorganic phosphorus, a marked increase in blood glucose and plasma cortisol, no change in histamine or serotonin, and an increase in plasma catecholamines. Transaminases (SGOT and SGPT) rose slightly, while there was no change in the blood urea nitrogen or creatinme. This anesthetic appears to deserve clinical evaluation.
Highly enantio- and diastereoselective synthesis of β-methyl-γ-monofluoromethyl-substituted alcohols.
Enanatiopure β-methyl-γ-monofluoromethyl alcohols were prepared from the allylic alkylation between fluorobis(phenylsulfonyl)methane with Morita-Baylis-Hillman carbonates. The reaction was catalyzed by using the Cinchona alkaloid derivative, (DHQD)(2)AQN. The origin of the stereoselectivity was verified by DFT methods. Calculated geometries and relative energies of various transition states strongly support the observed stereoselectivity.