NMR study of alkaloids. V.13C NMR spectra and reconsideration of the structures of 11- and 10-hydroxypleiocarpamines and the structures of new alkaloids fromVinca erecta
The structures of phenolic alkaloids isolated previously fromVinca erecta Rgl. et Schmalh. have been reconsidered on the basis of the results of a study of their13C NMR spectra, and it has been shown that a base with mp 228–229° has the structure of 11-hydroxystrictamine and an amorphous base of the same composition isomeric with it is 10-hydroxystrictamine. The structures of two new indolenine alkaloids — ercinamine and ercinaminine — have been determined from an analysis of13C NMR spectra, and also on the basis of PMR and IR spectra and chemical transformations.
Medicinal Plants of Uzbekistan and Their Traditional Uses
Uzbekistan is known throughout the world for its rich history of herbal plants and their use in traditional medicine. Uzbekistan significantly surpasses other regions of the world in terms of the endemism and species richness found in this country. These plants are a source for biologically active compounds that are used in pharmacological tests, with a high probability of new drug discovery. Pharmacological studies have confirmed that plant extracts and individual compounds have various biological activities such as hepatoprotective, dermatological, antimicrobial, antiviral, anti-ulcer, antioxidant, neuroprotective, and antiinflammatory properties. In the present review, an attempt was made to provide an up-to-date report on the diversity of medicinal plants widely used in Uzbekistan and their pharmacological properties. The present report can be useful for the continuous investigation of the Uzbek with the aim of obtaining new biologically active compounds.
Phloroglucinol derivatives from Hypericum japonicum.
The isolation and identification of a new phloroglucinol derivative (2), a diterpenol (4), together with the known compounds flavesone (1) and sarothralen B (3), from the aerial parts of Hypericum japonicum are reported. Their structures were established by extensive spectral analysis and the structure of (3) has also been confirmed by a single crystal X-ray determination.