Coumarins of Ferula kopetdaghensis and the structure of kopeolin and kopeoside
SummaryThe roots ofFerula kopetdaghensis Eug. Kor. have yielded five coumarins — umbelliferone and four new compounds (kopetin, kopeodin, kopeolin, and kopeoside).On the basis of NMR, mass, and IR spectroscopy, derivatives, and transformation products, the structures of two of the new coumarins kopeolin and kopeoside have been established. It has been shown that kopeolin is a derivative of farnesiferol C and kopeoside is kopeolin 3-O-β-D-glucoside.
Biological activities of farnesiferol C: a review
Abstract Farnesiferol C (FC) is a sesquiterpene coumarin, with a unique chemical structure, isolated from Ferula (Apiaceae) species including Ferula assa-foetida and Ferula szowitsiana. The compound is an important natural product with different biological activities. Recently, researchers have been interested in FC and begun to investigate its biological effects. They have shown that FC possesses various biological properties including cytotoxic, apoptotic, MDR reversal, antitumor, antimutagenic, and antiviral activity. In addition, FC has shown moderate neuroprotective activity against oxygen–glucose deprivation in vitro. This review summarizes the biological activities of FC that has been published to date. A complete search performed on relevant databases consists of Pubmed, Scopus, Web of science, Google scholar, Science direct, and Magiran. Selected keywords were sesquiterpene coumarin, farnesiferol C, biological activity, cytotoxicity, pharmacology, anticancer, and anti-angiogenesis. All of the data were checked out and irrelevant articles were discarded.
Zur Kenntnis der Sesquiterpene und Azulene. 126. Mitteilung. Über die Inhaltsstoffe der Asa foetida I. Farnesiferol A
From the non-volatile, neutral fraction of Asa foedita (Umbelliferae) 3 isomeric compounds C24H30O4, designated farnesiferol A, B, and C, have been isolated. Farnesiferol A (I) is a mixed ether of umbelliferone with a sesquiterpene moiety of the bicyclofarnesylic type. It might arise biogenetically by oxidative cyclisation of the known umbelliprenine (XXXII).