Study on Risk Management of Investment on Food and Drug Safety of Fiddlehead
Fiddlehead has been used in traditional Chinese medicine since Han Dynasty. However fiddlehead are still underutilized and hence wasted. In order to better utilize fiddlehead resources, the drug safety of benzene/alcohol extractives from fiddlehead were analyzed by GC/MS. Relative content of each component was determined by area normalization. The main ingredients of benzene/alcohol extractives of fiddlehead were toluene,2-furancarboxaldehyde, 5-(hydroxym ethyl)-, n1-(4-hydroxybutyl)-n3-methylguani dine acetate, 1,3-dihydroxyacetone dimer, sulfurous acid, cyclohexylmethyl hexadecyl ester, 1,4,7,10,13,16-hexaoxanonadecane, 18-propyl-, 1,6-anhydro-.beta.-d-glucopyranose(levoglucosan), oxirane, hexadecyl-, etc. The results obtained fully indicated that the benzene/alcohol extractives of fiddlehead had the great potential of noble natural biomedicines.
Study on Biomedical Resources of Benzene/Alcohol Extractives of Eucalyptus Leaves by GC/MS
Eucalyptus leaves have been used as a common traditional herbal medicine for more than 200 years. In order to further utilize Eucalyptus leaves in biomedicine and put forward new ideas for biomedical manufacturing, the biomedical resources of extractives of Eucalyptus dunnii and Eucalyptus grandis leaves were analyzed by GC/MS. The results showed that: 1) The main constituents of benzene/ethanol extractives in E. dunnii leaves were α-amyrin(9.05%), cyclohexyl-15-crown-5-(6.51%), 1,4,7, 10,13,16-hexaoxanonadecane, 18-propyl-(6.09%), vitamin E (5.83%), 1,19-eicosadiene(5.65%), 1,4-dioxane-2,6-dimethanol(5.32%), coumarin-6-ol, 3,4-dihydro -4,4-dimethyl-7-nitro-(4.42%), 2-furancarboxaldehyde, 5-(hydroxymethyl)- (4.21%), benzene, 1,2,3 -trimethoxy-5-methyl(3.45%), etc. 2) The main constituents of benzene/ethanol extractives in E. grandis leaves were (-)-globulol (7.35%), 1,2,3-benzenetriol(7.17%), D-allose(6.37%), 2- furancarboxaldehyde,5-(hydroxymethyl)-(6.33%), N1-(4-hydroxybutyl)-N3-methylguanidine acetate(5.35%), 1,4,7,10,13,16-hexaoxanonade–cane,18-propyl-(3.95%), vitamin E(3.26%), cyclohexyl-15-crown-5-(3.13%), eucalyptol(2.91%), etc. The results of function analyses suggested that the benzene/ethanol extractives of both E. dunnii and E. grandis leaves were abundant in materials of noble natural biomedicines, and also contained constituents which could be developed into top value-added materials of cosmetics and health care.
Effect of pretreatment with antibiotics on the hydrolysis of salicyluric acid in rabbit intestinal microorganisms.
The effect of pretreatment with antibiotics on the hydrolysis of salicyluric acid in rabbit intestinal microorganisms was investigated. Latamoxef sodium (LMOX, 25 mg/kg/d, intravenously) and cephalexin (CEX, 16.7 mg/kg/d, orally) were administered for 1 or 3 d. The blood concentration of salicyluric acid and salicylic acid following oral, intracecal and rectal administration of salicyluric acid was determined. By the pretreatment with LMOX for 1 or 3 d, the blood concentration of salicylic acid following oral administration of salicyluric acid was slightly decreased. In rabbits pretreated with CEX for 3 d, the blood concentration of salicylic acid was detected at low concentration. By the pretreatment with LMOX and CEX, however, the decrease in the blood concentration of salicylic acid following rectal administration of salicyluric acid was not observed. Although the examination of population of intestinal microorganisms induced by the pretreatment with antibiotics was not performed, the metabolic activity of intestinal microorganisms may be changed.