A method for hermetically packing solid medicinal forms
Four basic methods are in existence for protecting solid drugs from external influences: i) coating of tablets with a film by pelleting or in a fluidized bed; 2) packaging preparations in polymeric film materials; 3) packaging in metal foil; 4) packaging in mixed films consisting of aluminum foil and cellophane, polypropylene, or other polymeric material. This method has the widest application at the present time. Methods have been developed not only for packaging in mixed films but also automatic lines of diverse productivity have been established.
EVALUATION OF POLYMERIC MATERIALS. I. SCREENING OF SELECTED POLYMERS AS FILM COATING AGENTS.
A procedure has been developed for the systematic evaluation of mechanical, thermal, and stability properties of polymeric materials through the study of unsupported films. Films of selected vinyl, acrylic, and cellulosic polymers were prepared by the knife edge applicator method and the mercury substrate technique. The mercury substrate technique afforded superior control of film thickness and facilitated film removal. Films that were very permeable to water vapor were rather impermeable to oxygen and vice versa. This relationship is discussed as it relates to a combination of the hydrophilic-lipophilic and pore theories of film structure. The unsupported vinyl films possessed superior mechanical properties of those tested. Moisture absorption by the polymer films was negligible. There was no discernible decomposition according to infrared analysis of the films, due to thermal, photo-oxidation, and/or aging effects.
STUDIES ON TERRESTRIAL CONTAMINANTS OF METEORITES
During t h e l a s t ha l f d e c a d e a n unpara l le led upsu rge h a s t aken p l ace in t h e s tudy of meteor i tes , e s p e c i a l l y t h e ca rbonaceous chondr i tes . S c i e n t i s t s from all ove r t h e world, employing t h e newes t a n d most s e n s i t i v e an a1 y t i c a l t ec hni q u e s , i n v e s t i g a t e t h e ch e m i c a l composition of t h e o rgan ic mate t ia l found in t h e s e meteor i tes . In t h i s way they a r e trying to de te rmine t h e phys ica l c o n s t a n t s of t h e meteor i tes and e s t a b l i s h , on t h e b a s i s of minera logica l and petrolog ica l s t u d i e s , t h e cha rac t e r i s t i c s of t h e environmental condi t ions f r o m which t h e s e s t o n e s or ig ina ted and to desc r ibe and ident i fy cer ta in mic ros t ruc tu res which abound in s o m e of t h e s e ca rbonaceous chondr i tes . A l l of t h e s e research i n t e r e s t s a r e d i rec ted towards o n e pa r t i cu la r problem, t h e def in i te so lu t ion of which may indeed have revolutionary e f f e c t s o n ou r c o n c e p t s of t he universe. T h e ques t ion is whether or not t h e s e meteor i tes conta in t r a c e s of ex t ra t e r r e s t r i a l l i fe , t hus proving tha t some kind of biota eve r e x i s t e d o ther t han on t h e ear th , o r if a l l of t h o s e f ea tu res tha t t end to subs t a n t i a t e t h e prev ious ly mentioned h y p o t h e s i s a r e only t h e r e s u l t of contaminat ion by te r res t r ia l matter. T h e impor tance of t h i s problem w a s emphas ized by Berna l (1961: 130) in t h e following way: “ T h e v i t a l ques t ion cou ld be s e t t l e d o n c e and for a l l if s p e c i f i c molecu le s s u c h a s porphyrins o r nuc leo t ides were found. A counter ind ica t ion a t t he moment is t h e extremely low phosphorous conten t of t h e meteorite.” S ince tha t s t a t emen t w a s made, porphyrins (Hodgson & Baker, 1964) a n d poss i b l y nuc leo t ides (Nagy et al., 1963a) have been ident i f ied f r o m t h e Orgueil meteor i te , but s t i l l t he q u e s t i o n of t h e e x i s t e n c e of extrat e r r e s t r i a l life is far from be ing proven. I t is clear from the a b o v e tha t o n e of t h e b a s i c problems tha t o n e faces in t h e s tudy of meteor i tes is tha t of contamination. In order t o e s t a b l i s h unques t ionably t h e e x i s t e n c e o r p a s t e x i s t e n c e of ex t ra te r res t r ia l l i f e through t h e s t u d i e s of meteor i tes , two primary q u e s t i o n s h a v e to b e dea l t with s imul taneous ly . O n e h a s to d e c i d e