Triterpene glycosides of Cephalaria kotschyi and C. nachiczevanica
Methanolic extracts of the flowers and roots of each species were evaporated to dryness separately, the residues were dissolved in water, and the solutions were washed with chloroform and ethyl acetate and were then extracted with n-butanol. The concentrated butanolic extracts were purified by chromatography on KSK silica gel in the butan-l-ol-methanol (3:1) system. According to thin-layer chromatography (TLC) on silica gel in the butan-l-ol-methanoi--25% ammonia (10:2:5) system, the combined saponins isolated contained seven triterpene glycosides, which were called, in order of increasing polarity, cephalarosides A, B, C, D, E, F, and G. The compositions of the glycosides of the two plants proved to be identical.
APORTES FITOQUIMICOS A LA SISTEMATICA DE LA FAMILIA DIPSACACEAE PHYTOCHEMICALS CONTRIBUTIONS TO THE DIPSACACEAE SYSTEMATIC
This work is part of a review of the Dipsacaceae family and its contributions. The chemistry is diversified to 89 species, such us glycosides triterpenes, flavonoids, iridoids and phenylpropanoids that are considered as taxonomy indicators, due its occurrence number and structural diversity. In fact, the analysis of the correlations between chemistry parameters about the basis of selected seconday metabolities with morphological parameters permits the reorganization of the systematic. Indeed, phenypropanol derivatives served as markers of Morinaceae, as well as absence of flavonoids permitted the recognition of Triplostegiaceae. Dipsacaceae, Morinaceae and Triplostegiaceae families presents differences in the production of its secondary metabolites, confirming the recognition of two segregate families from the Dipsacaceae and their systematic from a phytochemical point of view.
Clozapine derived 2,3-dihydro-1H-1,4- and 1,5-benzodiazepines with D4 receptor selectivity: synthesis and biological testing.
Novel 4-arylpiperazin-1-yl-substituted 2,3-dihydro-1H-1,4- and 1H-1,5-benzodiazepines and their aza-analogues were synthesized as debenzoclozapine derivatives for evaluation as potential D4-ligands. While Ki values of some of the title compounds came within the range of clozapine, they showed an impressively greater selectivity over other dopamine receptor subtypes, especially D2. For the most promising compounds, intrinsic activity and binding properties to serotonin 5-HT1A and 5-HT2 were also determined.