Of Poets and Barbarians: Challenging Linguistic Hierarchies in Cervantes’s Los trabajos de Persiles y Sigismunda
Is style an ornamental feature of writing separate from the content or can it be a vehicle of political and ethical expression? This essay takes as point of departure the incipit of Miguel de Cervantes’s posthumously published epic novel, Los trabajos de Persiles y Sigismunda (1617) to argue for a richer understanding of style. More specifically, it shows how through the use of a high epic style in the Persiles Cervantes questions central humanist tenets and assumptions about the relation of language to humanity, of individual speakers and linguistic communities, as well as the expectations of a linguistic chain of being that would unflinchingly equate clarity of speech with civilization. By focusing on the representation of barbarian speech, this essay examines the ways in which Cervantes’s work offers a more ethical alternative to classical and Renaissance epic models that would either deny speech to barbarians or limit barbarian speech to the enabling curse that will get the heroic adventures going. By making the barbarian’s words intelligible through translation and more daringly, by making that very act of translation effect a change in the very texture of the receiving language itself, barbarolalia in Persiles emerges as poetry’s twin.
Los trabajos de Persiles y Sigismunda
Yo, Jeronimo Nunez de Leon, escribano de Camara del rey nuestro senor, de los que en su Consejo residen, doy fee que, habiendose visto por los senores del un libro intitulado Historia de los trabajos de Persiles y Sigismunda, compuesto por Miguel de Cervantes Saavedra, que con licencia de los dichos senores fue impreso, tasaron cada pliego de los del dicho libro a cuatro maravedis, y parece tener cincuenta y ocho pliegos, que al dicho respeto son docientos y treinta y dos maravedis, y a este precio mandaron se vendiese, y no a mas, y que esta tasa se ponga al principio de cada libro de los que se imprimieren. E, para que de ello conste, de mandamiento de los dichos senores del Consejo, y de pedimiento de la parte del dicho Miguel de Cervantes, doy esta fee. En Madrid, a veinte y tres de deciembre de mil y seiscientos y diez y seis anos. Geronimo Nunez de Leon. Tiene cincuenta y ocho pliegos, que, a cuatro maravedis, monta seis reales y veinte y ocho maravedis.
Sources of Information on Lymphoma Associated with Anti-Tumour Necrosis Factor Agents
AbstractBackground: Anti-tumour necrosis factor (TNF) agents, through their intense immunoregulatory effect, have been suspected to increase the risk of malignant lymphoma. However, the classical epidemiological approaches conducted over about the last 10 years have not totally succeeded in addressing the question of a causal or artifactual association. Therefore, the analysis of a substantial set of case reports, although usually considered as poorly generalizable to the general population, could be particularly informative. Two main sources of case reports in postmarketing settings are available; publications in medical journals and reports to pharmacovigilance systems.
 Objective: The aim of the study was to compare the characteristics of case reports from both these sources in order to understand whether they provided the same information for the investigation of the causal link between lymphoma and anti-TNF agents.
 Methods: All case reports of malignant lymphoma in patients treated with an anti-TNF agent published in MEDLINE and all reports to the French pharmacovigilance system up to 1 February 2010 were identified. Cases of malignant lymphoma identified in postmarketing surveillance from both sources were compared regarding the following variables: age, sex, anti-TNF agent involved, indication for use, type of lymphoma, prior or concomitant immunosuppressive drugs and time to onset of lymphoma.
 Results: A total of 81 published case reports and 61 cases reported to the French pharmacovigilance system were compared. In published reports, patients were younger (p = 0.03) and more frequently receiving a first anti-TNF treatment (p = 0.03), particularly infliximab (p = 0.03). Conversely, in the pharmacovigilance system reports, a succession of different anti-TNFs (p = 0.03) and adalimumab (p< 0.0001) were more frequently reported. Lymphomas in patients treated with anti-TNF agents for Crohn’s disease were more prevalent in published cases than in pharmacovigilance reports (p< 0.0001), and in particular involved hepatosplenic T-cell lymphoma. Conversely, rheumatoid arthritis was the main indication for anti-TNF agents in pharmacovigilance reports (p = 0.01). Time to onset was markedly shorter in published cases (median 12 months) than in pharmacovigilance reports (median 30 months; p = 0.0001).
 Conclusions: Characteristics of published cases and those reported to the French pharmacovigilance system differed markedly for all characteristics tested, except sex and the use of prior or concomitant immunosuppressive drugs. Published case reports favoured convincing arguments for drug causation whereas cases reported to the pharmacovigilance system were more disparate but could describe more accurately the reality of lymphoma occurrence in this particular population. These results argue for the use of the pharmacovigilance reports when case reports are used to investigate the causal link between lymphoma and anti-TNF agents at the population level. Data from cases notified to the French pharmacovigilance system did not indicate an increased risk of lymphoma during the early phase of anti-TNF treatment. To confirm this hypothesis, a study combining pharmacovigilance reports from several countries, or, if feasible, a cohort study both with a large sample size and a long duration of follow-up would be required.