Status of China in Science and Technology as Reflected in its Publications Output, 1997–2007
The study examines China’s performance in science and technology (S&T) during 1997–2007, based on several parameters including the country’s annual average growth rate, global publication share and rank, strong and weak subject areas (in terms of national priority, international collaborative share and global share), institutional profiles of select top institutions, the overall international collaboration profile and major collaborative partners, patterns of communication in national and international journals and characteristics of its top highly cited papers. The study also compares similarities of China’s research profile with nineteen other top productive countries.
China ranks second in scientific publications since 2006
With the fast development of its economy, China plays an increasingly important role in the world. China's performance in science is also impressive. The exponential growth of Chinese scientific publications provides evidence. However, statistical results about China's world share of scientific publications provided by different institutions and researchers have been in disagreement. With the data for 2007 being now available, we provide an update on this issue and conclude that China has become the second largest producer of scientific publications since 2006.
Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform
This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, the effectiveness of 20 dicarboxylic acids to generate a specific cross-linked hydrogel capable of supporting different amounts of γ-cyclodextrin (γ-CD) was evaluated. According to the interaction energies calculated with the in-silico studies, the hydrogel made from PVA cross-linked with succinic acids (SA) was shown to be the best candidate for containing γ-CD. Later, molecular dynamics simulation studies were performed in order to evaluate the intermolecular interactions between PDN and three cross-linked hydrogel formulations with different proportions of γ-CD (2.44%, 4.76% and 9.1%). These three cross-linked hydrogels were synthesized and characterized. The loading and the subsequent release of PDN from the hydrogels were investigated. The in-silico and experimental results showed that the interaction between PDN and γ-CDHSA was mainly produced with the γ-CDs linked to the hydrogels. Thus, the unique structures and properties of γ-CDHSA demonstrated an interesting multiphasic profile that could be utilized as a promising drug carrier for controlled, sustained and localized release of PDN.