Gender differences in DNA damage/repair after laser-generated ultrafast electron beam irradiation
The laser-generated electron acceleration is a developing technology, which can make a revolution in radiation therapy of tumors. The possibility of creating directed ultra-short pulses of enormous capacity (up to kGy/s) allows the precise dose-control induction of local effects on solid tumors with minimal exposure of normal tissues. The obvious advantage of laser-generated electron accelerators is also the significantly smaller size and cost than that of conventional radiotherapy machines.1 There are only a few publications on the biological effects of ultra-short pulsed electron beam radiation.2–5 However, before translating the usage of lasergenerated accelerators into clinical practice, the radiobiological effectiveness of such ultra-short electron bunches should be approved.
The LD50 for Low-Energy Ultrashort-Pulsed Laser Driven Electron Beam Whole-Body Irradiation of Wistar Rats
Recently, a new technology of low-energy ultrashort-pulsed electron beam (UPEB) accelerators has been developed opening new directions for radiobiology and biomedical research. The purpose of this study was to reveal the lethal dose, LD50 (lethal dose, 50%) delivered by low-energy UPEB whole-body exposure on an organismal level. Wistar rats were exposed to low-energy UPEB whole-body irradiation with different doses and pulse repetition rates to find the LD50 and in silico computer simulations were performed to conduct numerical dose calculations. Survival rate, body weight and water consumption were monitored over the 30-day observation period postirradiation. The LD50 was observed after a 2 Gy dose and pulse repetition rate of 2 Hz. In this group, 50% of the animals survived 30 days postirradiation. The groups of animals exposed to low-energy UPEB radiation at higher doses and pulse repetition rates demonstrated higher mortality rates. We demonstrated that the LD50 dose for the low-energy UPEB whole body irradiation in Wistar rats corresponds to 2 Gy with a pulse repetition rate of 2 Hz. Moreover, we showed that the pulse repetition rate is a very important parameter in the experiments with UPEB and should be assessed in the experiments with such kind of novel irradiation sources.
Experimental Study for a Double-Glazed Forced-Flow Solar Collector/Regenerator
Experimental study of a double-glazed forced-convection solar collector/regenerator for absorption solar cooling is presented. The south facing experimental solar collector/regenerator with 10 deg slope is located at Kaohsiung, Taiwan at 120{degree}19minutesE longitude and 22{degree}34minutesN latitude. The size of the collector is 1 m wide and 7 m long with an effective regeneration area of 0.9 m by 6 m. Previous study for single-glazed forced-convection solar collector/regenerator operated at the same location has shown to have a best day-average efficiency of 17%. In order to raise the system performance, a double-glazed collector/regenerator is constructed such that air can be preheated in the upper channel flow. The preheated air is then conducted into the lower channel where it contacts with the film flow of solar heated lithium-chloride solution and regenerates the solution by carrying out the evaporated water vapor. The preheated air has lower relative humidity but the same humidity ratio since it is sensibly heated. Therefore, the regeneration driving potential is increased. The present study shows that the best day-average efficiency can reach 20% which increases the feasibility of the open-cycle absorption solar cooling system. Effects of controlling parameters on the collector/regenerator performance are studied, and heat and mass transfer correlationsmore » are also presented for design purposes.« less