From Republicanism to Liberalism: Corruption and Empire in Enlightenment Political Thought
Debates about the relationship between empire and corruption were prominent in eighteenth century British political thought. Some of these debates were framed within classical Republican or Civic Humanist discourses, of which Charles-Louis Montesquieu and Adam Ferguson were emblematic exemplars. Within the terms of this discourse, corruption represented a collective moral failure, and was closely connected to a supposed cycle of imperial greatness and decline. Yet, similar fears of empire motivated the articulation of more modern, proto-liberal notions of corruption as forms of activity that blurred the boundaries between private interests and public responsibilities. In his analysis of the economic distortions and trading monopolies caused by empire (especially the East India Company), Adam Smith articulated and pioneered this proto-liberal concept of corruption. Between Smith’s proto-liberal and Montesquieu/Ferguson’s Republican concepts of corruption, however, stood the work of Edmund Burke. Motivated in part by concerns about empire, Burke shared Smith’s strong opposition to the EIC, an organisation he considered to be corrupt and corrupting. Emerging from his work, then, was an understanding of corruption that shared the Republican emphasis on moral decay, but also anticipated a proto-liberal concern with keeping distinct the boundaries between public (political) and private (economic) activity. In the work of these four thinkers corruption thus emerges as a central concept in the transition from Republican to Liberal political thought in the late eighteenth century.
Sir William Jones and Edmund Burke
MUCH has been written about Edmund Burke, and much more will undoubtedly be written about him in time to come, particularly now that his voluminous correspondence is being edited for publication. Today a ready source of interest is the men who associated with Burke, because those associations often throw light upon him and his multifold activities. For example, one of the important subjects to which he devoted himself was India. As in the case of
Pharmacokinetics of Mivacurium Isomers and Their Metabolites in Healthy Volunteers after Intravenous Bolus Administration
Background Previous studies report the pharmacokinetics of mivacurium isomers after an infusion using venous blood sampling. Although the extent of the mivacurium arterial‐venous gradient is not known, the sampling site is likely to influence mivacurium pharmacokinetic parameters because the drug is rapidly metabolized as it traverses the circulation. The objectives of this study were (1) to determine the pharmacokinetics of mivacurium isomers in healthy persons after intravenous bolus administration using intensive arterial blood sampling, and (2) to characterize the formation and elimination of mivacurium metabolites in human plasma. Methods Eight persons classified as American Society of Anesthesiologists physical status 1 or 2 who were scheduled to undergo elective surgery under balanced anesthesia received 0.15 mg/kg mivacurium chloride as an intravenous bolus. Arterial blood samples were collected every 10 s during the first 2 min and at frequent intervals for 4 h thereafter. Plasma concentrations of mivacurium isomers and their metabolites were determined by two stereoselective high‐performance liquid chromatographic methods coupled with fluorometric detection and noncompartmental pharmacokinetic parameters. Results Mean elimination half‐lives of the trans‐trans, cis‐trans, and cis‐cis isomers were 2.4, 2, and 28.5 min, respectively, with corresponding mean plasma clearances of 29.2, 45.7, and 6.7 ml [center dot] min‐1 [center dot] kg‐1. The volumes of distribution at steady state of the trans‐trans, cis‐trans, and cis‐cis isomers were 0.047, 0.054, and 0.189 l/kg, respectively. Plasma concentrations of monoester and alcohol metabolites peaked 25 s (median) after mivacurium injection, with half‐lives in the range of 90 min, except for the cis alcohol metabolite, which was only negligibly and transiently formed. Conclusions Substantial hydrolysis of mivacurium isomers by cholinesterases was confirmed by the rapid appearance of mivacurium metabolites in plasma. The intensive arterial sampling proved to be critical for the trans‐trans and cis‐trans isomers because the area under the curve between 0 and 2 min accounted for 75% and 86% of the total, respectively.