Design of an optimal damper to minimize the vibration of machine tool structures subject to random excitation
The vibration of machine tools during machining adversely affects machining accuracy and tool life, and therefore must be minimized. The cutting forces for stable turning are generally known to be random, and hence excite all the resonance modes. Of all these modes, those that generate relative motions between a cutting tool and a workpiece are of concern.This paper presents a new approach for designing an optimal damper to minimize the relative vibration between the cutting tool and workpiece during stable machining. An approximate normal mode method is employed to calculate the response of a machine tool system with nonproportional damping subject to random excitation. The major advantage of this method is that it reduces the amount of computation greatly for higher-order systems when responses have to be calculated repeatedly in the process of optimization. An optimal design procedure is presented based on a representative lumped parameter model that can be constructed by using existing experimental or analytical techniques. The two-step optimization procedure based on the modified pattern search and univariate search effectively leads the numerical solution to the global minimun irrespectively of initial values even under the existence of many local minima.
A Finite Element Program System and Its Application for Machine Tool Structural Analysis
A brief introduction to the finite element method is given, and a program system is described which permits structures to be analysed with respect to their static characteristics. The first part of the system is applicable to the deformation computation of structures approximated by flat elements and beams. The second part of the program system is used for the analysis of deformations and stresses in continuous three-dimensional components.
An injectable and thermosensitive hydrogel: Promoting periodontal regeneration by controlled-release of aspirin and erythropoietin.
Periodontitis is an inflammatory disease induced by complex interactions between host immune system and plaque microorganism. Alveolar bone resorption caused by periodontitis is considered to be one of the main reasons for tooth loss in adults. To terminate the alveolar bone resorption, simultaneous anti-inflammation and periodontium regeneration is required, which has not appeared in the existing methods. In this study, chitosan (CS), β-sodium glycerophosphate (β-GP), and gelatin were used to prepare an injectable and thermosensitive hydrogel, which could continuously release aspirin and erythropoietin (EPO) to exert pharmacological effects of anti-inflammation and tissue regeneration, respectively. The releasing profile showed that aspirin and EPO could be continuously released from the hydrogels, which exhibited no toxicity both in vitro and in vivo, for at least 21 days. Immunohistochemistry staining and micro-CT analyses indicated that administration of CS/β-GP/gelatin hydrogels loaded with aspirin/EPO could terminate the inflammation and recover the height of the alveolar bone, which is further confirmed by histological observations. Our results suggested that CS/β-GP/gelatin hydrogels are easily prepared as drug-loading vectors with excellent biocompatibility, and the CS/β-GP/gelatin hydrogels loaded with aspirin/EPO are quite effective in anti-inflammation and periodontium regeneration, which provides a great potential candidate for periodontitis treatment in the dental clinic. Statement of Significance To terminate the alveolar bone resorption caused by periodontitis, simultaneous anti-inflammation and periodontium regeneration is required, which has not appeared in the existing methods. Here, (1) the chitosan (CS)/β-sodium glycerophosphate/gelatin hydrogels loaded with aspirin/erythropoietin (EPO) can form at body temperature in 5 min with excellent biocompatibility in vitro and in vivo; (2) The faster release of aspirin than EPO in the early stage is beneficial for anti-inflammation and provides a microenvironment for ensuring the regeneration function of EPO in the following step. In vivo experiments revealed that the hydrogels are effective in the control of inflammation and regeneration of the periodontium. These results indicate that our synthesized hydrogels have a great potential in the future clinical application.