Kinetcis of silicothermic reduction of clacined dolomite in flowing argon atmosphere
The magnesium vapour extracted is removed using vacuum condition to condense as a dense metal. Thermodynamic analysis of this process has been carried out in the past to predict the distribution of the metal impurities in condensed magnesium. The results suggested that a number of impurities in different phases formed in the region between reaction zone and condenser. The thermodynamic results only are not sufficient to describe the process, and the knowledge of the kinetics of the Pidgeon process is required. Kinetics plays important role to give more insight to the process such as for process design and control.
Producing Pure Magnesium Through Silicothermic Under the Atmospheric Pressure
The majority of pure magnesium produced worldwide is made by using silicothermic method (Pidgeon process). However, the Pidgeon process suffers poor efficiency, low industrial concentration, and intermittent production. The main reason is that Pidgeon process requires to keep the reaction chamber in a vacuum state during the entire reduction process. By analyzing the thermodynamic reaction principle, we reveal that it is the low magnesium partial pressure instead of vacuum that is necessary for the silicothermic process. Based on this understanding, we develop a new technique that can produce pure magnesium under the atmospheric pressure by using silicothermic method. Flowing argon is used to carry away the magnesium vapor around the reactants, which reduces the local magnesium partial pressure. The magnesium production efficiency reaches 82.36% that is comparable to the widely used Pidgeon method, and high purity of magnesium with 99.97 wt% after melting is produced directly. The industrialized application of this exciting technique is expected to help the silicothermic to realize high efficiency, automated, and continuous production while at the same time completely change the poor production conditions, and reduce energy consumption and pollution.
Atomistic insight into novel co-delivery of doxorubicin and paclitaxel using fullerene modified by dimethyl acrylamide trimethyl chitosan: A computational study

 Background: The distribution of drugs could not be controlled in the conventional drug delivery system. This has led to the development of a smart nanoparticle-based drug delivery system, known as smart drug delivery systems. In cancer research, novel biocompatible nanocarriers have received much attention for various ranges of anticancer drugs.In the current study, the effect of a novel co-polymer "dimethyl acrylamide-trimethyl chitosan" was investigated on drug delivery of doxorubicin and paclitaxel utilizing modified fullerene nanocarrier. This study was performed via molecular dynamics simulation based on acidic pH sensitivity of the cancer microenvironment. Furthermore, hydrogen bonds, diffusion coefficient, gyration radius, and drug-carrier interaction energies were investigated here. Interestingly, a simultaneous pH and temperature-sensitive system was proposed for paclitaxel and doxorubicin for a co-polymer. A pH-sensitive and temperature-sensitive copolymer was used based on trimethyl chitosan and dimethyl acrylamide, respectively. In such a dualistic approach, co-polymer makes an excellent option to have two properties in one bio-polymer. Results: The results suggest the dramatic and indisputable role of the co-polymer in the release of doxorubicin and paclitaxel in cancerous tissues, as well as an increased biocompatibility and drug uptake in a neutral state. The validation test was performed by repeated simulations of a similar article. The results are very close to those of the reference paper .Conclusions: Overall, conjugated fullerene and dimethyl acrylamide-trimethyl chitosan (DMAA-TMC) as carriers can be a good proposition for loading, delivery, and release of anti-cancer drugs based on a pH/temperature-sensitive smart drug delivery system.