A Modern Apparatus for Performing Flash Chromatography: An Experiment for the Organic Laboratory.
A modern apparatus for performing flash chromatography using commercially available, prepacked silica cartridges has been developed. The key advantage of this system, when compared to traditional flash chromatography, is its use of commercially available silica cartridges, which obviates the need for students to handle silica gel. The apparatus has been tested for its ability to perform separations that are commonly found in organic chemistry teaching laboratories, and a laboratory module that combines the techniques of thin-layer chromatography, gas chromatography, and flash chromatography is described. The performance of this new chromatography apparatus was comparable to a traditional flash chromatography column.
Solution-Phase Synthesis of Dipeptides: A Capstone Project That Employs Key Techniques in an Organic Laboratory Course
A contemporary approach to the synthesis and purification of several UV-active dipeptides has been developed for the second-year organic laboratory. This experiment exposes students to the important technique of solution-phase peptide synthesis and allows an instructor to highlight the parallel between what they are accomplishing in the laboratory to the advancements being made in the pharmaceutical industry. By illustrating the importance of protecting group strategy and stereochemistry preservation, while also reinforcing the various separatory and purification techniques learned throughout the typical laboratory course, this experiment serves as an excellent candidate for a capstone project that assesses students’ mastery of important techniques learned in an introductory organic laboratory course.
Catalytic removal of tert-butyldimethylsilyl (TBS) ether by PVP-I
Abstract A mild, efficient and rapid protocol the deprotection of alcoholic TBDMS ethers using PVP-1 as catalyst in methanol, the procedure of deprotection of various TBDMS ethers were found to be very convenient, easy work-up, high yielding.