Tenoxicam-kollicoat IR binary systems: physicochemical and biological evaluation.
Tenoxicam (TNX) binary systems in Kollicoat IR (KL) matrix were prepared in different drug: polymer ratios using kneading and spray-drying method. The prepared binary systems were characterized for drug dissolution rate, differential scanning calorimetry (DSC), IR spectroscopy and x-ray diffractometry. The results showed that the drug dissolution rate was remarkably enhanced by incorporating it in the KL matrix either by kneading or spray-drying, and the dissolution rate was increased by decreasing the drug weight ratio. The DSc and x-ray studies revealed the presence of TNX in less crystalline or amorphous state in its-KL binary systems. Moreover, the spray-dried TNX-KL system in 1:4 ratio, that exhibited the faster dissolution rate, was formulated in oral disintegrating tablets (ODTs). The data indicated that a fast disintegration and higher drug dissolution rate was achieved in case of the ODTs containing the spray-dried form compared to the ODTS containing untreated drug or the commercial tablet (Epicotil). Also, the drug exhibited significantly (p < 0.01) faster onset of the anti-inflammatory analgesic activities in case of the ODTs containing the spray-dried form, that was superior to that observed with both the commercial tablet product and the ODTS containing untreated drug.
Solubility Enhancement , Formulation and Evaluation of Furosemide Stomach Specific Mucoadhesive Tablet
International Journal of Pharmaceutical Sciences Review and Research International Journal of Pharmaceutical Sciences Review and Research Available online at www.globalresearchonline.net © Copyright protected. Unauthorised republication, reproduction, distribution, dissemination and copying of this document in whole or in part is strictly prohibited. Available online at www.globalresearchonline.net 258 Nora Zawar Yousif*, Sura Zuhair Mahmood, Zeina D. Salman Department of Pharmaceutics, College of Pharmacy, Al-Mustansiriyah University, Baghdad, Iraq. *Corresponding author’s E-mail: nazawara@yahoo.com
Simulation Analysis of Local Heat Treatment Formability of an Aerospace Aluminum Alloy Frame Parts
Wang Zhijian1,a, Guo Fangyu1,b, Shang Xiaofeng1,c, Song Hongwu2,d, Wang Ling3,e and Wang Jiale1,f 1School of Mechatronics Engineering, Shenyang Aerospace University, Shenyang 110136, China 2Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, China 3Shenyang aircraft industry company, Shenyang 110134, China aWangzhijian1974@sina.com, b1486121506@qq.com, c1009074102@qq.com dhwsong@imr.ac.cn, ew_ling2008@aliyun.com, f1591897439@qq.com