Surgery at lowered body temperatures.
The reduction of total body temperature (24–26° C) has been employed in surgery only in the past few years, although it has been used for other purposes since 1930. The problems associated with bodily responses to the process of cooling are by no means thoroughly understood, nor are the therapeutic possibilities of the principle fully explored. It would seem to be more profitable to solve the first problem before pursuing too strenuously the second.
Further experiences with hypothermia for intracardiac surgery in monkeys and groundhogs.
FURTHER EXPERIENCES WITH HYPOTHERMIA FOR INTRACARDIAC SURGERY IN MONKEYS AND GROUNDHOGS W. Bigelow;J. McBibnie; Annals of Surgery
A COMPARISON OF THE EFFECTS OF HEAT AND THOSE OF COLD IN THE PREVENTION AND TREATMENT OF SHOCK
There has been a revival of interest in recent years in the reactions of living matter to changes in temperature. From the therapeutic point of view the effects of fever therapy in the treatment of infections, of low temperatures in the retardation of growth of cancer 1 and of cooling parts with deficient circulation in the prevention of gangrene 2 have been studied. In addition to determining the effects of different temperatures on the local tissues in which the circulation was inadequate, Allen 2b found that constriction of the circulation of the thigh is more apt to be accompanied with shock if the local temperature is high than if it is low. Because of the variability in individual responses to various means of producing shock, such as trauma and the removal of blood, it is extremely difficult to compare the effects of various therapeutic agents. In other words, the variation