Artefactual pyruvate and 2-oxobutyrate produced by trimethylsilylation of methylmalonic and ethylmalonic acids in the presence of oxygen
Trimethylsilylation of methylmalonic and ethylmalonic acids in the presence of headspace atmospheric oxygen is shown to produce the trimethylsilyl derivatives of pyruvic and 2-oxobutyric acids, along with 2-hydroxy-2-methylmalonic and 2-hydroxy-2-ethylmalonic acids, respectively. This may lead to overestimation of these keto acids, if they were not oximated in the original sample, and the mistaken reporting of the 2-hydroxymalonates.
Trimethylsilylation of malonate ester enols.
Malonic acid silylates readily to yield the expected bis-trimethylsilyl (TMS) ester; this ester reacts further in the silylating mixture to yield a tris-TMS derivative, apparently through enolization of one of the ester groups. Methylmalonic and hydroxymalonic acids behave similarly. The methyl and ethyl esters of malonic acid also silylate once with some facility. Mass spectra of these derivatives are presented
Evidence of spurious results along with spatially autocorrelated errors in the context of geographically weighted regression for two independent SAR(1) processes
AbstractThe aim of this paper is to examine the performance of the geographically weighted regression (GWR) technique in terms of recognizing linear relationships at the local level. Using a Monte Carlo analysis with two independent spatially autocorrelated SAR(1) processes, this study finds that spurious behavior exists at the local level along with spatially autocorrelated errors. Therefore, GWR estimation results must be interpreted with caution.
