CONTACT PHOTOALLERGY TO TRIBROMSALICYLANILIDE
SUMMARY. .
Primary sensitization potentials of some halogenated salicylanilides and their cross-sensitivity in guinea-pigs.
Abstract Contact sensitization potentials of some halogenated salicylanilides were studied in guineapigs after topical immunization with the compounds in acetone with the aid of heat-killed Mycobacterium tuberculosis as an adjuvant. When challenged and rechallenged with the inducer allergen, the treated animals had the following responses: strong to 4′-monobromosalicylanilide (4′-MBS) and 3,3′,4,5-tetrachlorosalicylanilide (TCSA), weak to strong to 4′,5-dibromosalicylanilide (4′,5-DBS), weak to moderate to 3,5-dibromosalicylanilide (3,5-DBS), negligible to weak to 5-bromosalicylanilide (5-MBS) and 3,4′,5-tribromosalicylanilide (TBS), and negligible to 2′,3,4′,5-tetrabromosalicylanilide (tetra-BS). The relative contact sensitization pattern after repeated challenges was TCSA > 4′-MBS > 4′,5-DBS > 3,5-DBS > 5-MBS > TBS > tetra-BS, and closely parallels the pattern in man. When each immunized animal group was challenged with the inducer allergen plus six other halogenated salicylanilides, the guinea-pigs strongly sensitized to 4′-MBS showed a weak cross-sensitivity to 4′,5-DBS and TCSA. All other groups had no cross-sensitivity or a negligible response to all other halogenated salicylanilides. When guinea-pigs were immunized with a topical application of TBS in soap or in acetone and challenged with TBS in aqueous soap, they showed a strong sensitization.
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