Analysis of Geomechanical Properties in Well Design and Well Optimization
Main aspect in wellbore instability is the selection of an appropriate rock failure criterion. This criterion involves only the maximum and minimum principal stresses 1  and 3  and therefore assumes that the intermediate stress 2  has no influence on the rock strength. When Mohr-Coulomb criterion was developed it justified by experimental evidence from conventional triaxial test ( 1  > 3 2    ). Based on triaxal failure machine the Mohr-Coulomb criterion has been extensively used to represent rock failure under the polyaxial stress state ( 1  > 3 2    ). In contrast to the prediction of redistribution Mohr-Coulomb much evidence has been accumulating to suggest that 2  thus indeed have a strengthening effect. This research shown that Mohr-Coulomb failure criterion only represent, that triaxial stress state ( 1  = 1 2 3     or ) which only occasionally encountered in-situ.The linear failure criterion has been justified by experimental evidence from triaxial tests as well as polyaxial test. It is natural extension of the classical Mohr-Coulomb criterion into three dimensions. As the Mohr-Coulomb criterion only represents rock failure under triaxial stress state, it is expected to be conservative in predicting well bore instability. The 3D analytical model employed by MogiCoulomb has been achieved by using linear elasticity theory to calculate the stresses. A model was developed used in analyzing shale intrusion, at depth 6100ft the well bore pressure of the formation is found to be 0.9180psi/ft and decreases to 0.420psi/ft at depth 7300ft. The membrane efficiency of the formation increases from 0.698 to 0.719 at the depth considered above.
Groundwater Flow in Low‐Permeability Environments
Certain geologic media are known to have small permeability; subsurface environments composed of these media and lacking well developed secondary permeability have groundwater flow sytems with many distinctive characteristics. Moreover, groundwater flow in these environments appears to influence the evolution of certain hydrologic, geologic, and geochemical systems, may affect the accumulation of pertroleum and ores, and probably has a role in the structural evolution of parts of the crust. Such environments are also important in the context of waste disposal. This review attempts to synthesize the diverse contributions of various disciplines to the problem of flow in low-permeability environments. Problems hindering analysis are enumerated together with suggested approaches to overcoming them. A common thread running through the discussion is the significance of size- and time-scale limitations of the ability to directly observe flow behavior and make measurements of parameters. These limitations have resulted in rather distinct small- and large-scale approaches to the problem. The first part of the review considers experimental investigations of low-permeability flow, including in situ testing; these are generally conducted on temporal and spatial scales which are relatively small compared with those of interest. Results from this work have provided increasingly detailed information about many aspects of the flow but leave certain questions unanswered. Recent advances in laboratory and in situ testing techniques have permitted measurements of permeability and storage properties in progressively “tighter” media and investigation of transient flow under these conditions. However, very large hydraulic gradients are still required for the tests; an observational gap exists for typical in situ gradients. The applicability of Darcy's law in this range is therefore untested, although claims of observed non-Darcian behavior appear flawed. Two important nonhydraulic flow phenomena, osmosis and ultrafiltration, are experimentally well established in prepared clays but have been incompletely investigated, particularly in undisturbed geologic media. Small-scale experimental results form much of the basis for analyses of flow in low-permeability environments which occurs on scales of time and size too large to permit direct observation. Such large-scale flow behavior is the focus of the second part of the review. Extrapolation of small-scale experimental experience becomes an important and sometimes controversial problem in this context. In large flow systems under steady state conditions the regional permeability can sometimes be determined, but systems with transient flow are more difficult to analyze. The complexity of the problem is enhanced by the sensitivity of large-scale flow to the effects of slow geologic processes. One-dimensional studies have begun to elucidate how simple burial or exhumation can generate transient flow conditions by changing the state of stress and temperature and by burial metamorphism. Investigation of the more complex problem of the interaction of geologic processes and flow in two and three dimensions is just beginning. Because these transient flow analyses have largely been based on flow in experimental scale systems or in relatively permeable systems, deformation in response to effective stress changes is generally treated as linearly elastic; however, this treatment creates difficulties for the long periods of interest because viscoelastic deformation is probably significant. Also, large-scale flow simulations in argillaceous environments generally have neglected osmosis and ultrafiltration, in part because extrapolation of laboratory experience with coupled flow to large scales under in situ conditions is controversial. Nevertheless, the effects are potentially quite important because the coupled flow might cause ultra long lived transient conditions. The difficulties associated with analysis are matched by those of characterizing hydrologic conditions in tight environments; measurements of hydraulic head and sampling of pore fluids have been done only rarely because of the practical difficulties involved. These problems are also discussed in the second part of this paper.
Production of new antituberculosis drug and other medical preparations by electron beam treatment
Abstract Possibility of electron beam usage for immobilization of hydrazidum of an isonicotinic acid (HIA) on dextrane was studied to produce a drug for treatment of a tuberculosis. As a result of irradiation of dextrane the processes of oxidation and formation of polysaccharide occur due to carbonyl groups which are to link isoniasidum. The HIA immobilized on dextrane may be used as an effective medical preparation having prolonged action for action on endo and extracellular population of Micobacterium tuberculosis .