New Actors on the Horizon: The International Outreach of Italian CSOs
Italian civil society organisations are holding more and more sway in the foreign policy arena, strengthening links with their counterparts both in the European Union and further abroad. Some well-organised groups are increasingly capable of wielding influence in the international scenario, mainly thanks to their initiatives directed at fuelling citizens’ interests in sensitive issues and fostering transnational cooperation. In parallel with these global trends, Italian civil society is going through a period of change and reassessment, shaken by the need to protect some core values to which it is undeniably attached.
Italian hybrid diplomacy
ABSTRACT The text offers a new assessment of Italy’s contribution to international affairs. Through a more pluralist interpretation of Italian action at international level it is possible to outline an image of Italy as a normative power able to influence the formulation of the principles that determine what is legitimate at international level. Italy’s contribution in recent decades has been crucial in a series of transnational campaigns that have had a significant impact globally. These cases illustrate the role played by Italy in the politics of changing international norms related to human rights. The mobilisations have been the result of a combination of factors, including the intense synergy that has been established between the actions of the Italian government and Italian civil-society organisations. This study analyses eight cases in which such synergy has been positive, leading to a significant impact of Italian hybrid diplomacy on international politics.
Collagen dynamics in articular cartilage under osmotic pressure
Cartilage is a complex biological tissue consisting of collagen, proteoglycans and water. The structure and molecular mobility of the collagen component of cartilage were studied by 13C solid‐state NMR spectroscopy as a function of hydration. The hydration level of cartilage was adjusted between fully hydrated (∼80 wt% H2O) and highly dehydrated (∼30 wt% H2O) using the osmotic stress technique. Thus, the conditions of mechanical load could be simulated and the response of the tissue macromolecules to mechanical stress is reported. From the NMR measurements, the following results were obtained. (i) Measurements of motionally averaged dipolar 1H–13C couplings were carried out to study the segmental mobility in cartilage collagen at full hydration. Backbone segments undergo fast motions with amplitudes of ∼35° whereas the collagen side‐chains are somewhat more mobile with amplitudes between 40 and 50°. In spite of the high water content of cartilage, collagen remains essentially rigid. (ii) No chemical shift changes were observed in 13C cross‐polarization magic angle spinning spectra of cartilage tissue at varying hydration indicating that the collagen structure was not altered by application of high osmotic stress. (iii) The 1H–13C dipolar coupling values detected for collagen signals respond to dehydration. The dipolar coupling values gradually increase upon cartilage dehydration, reaching rigid limit values at ∼30 wt% H2O. This indicates that collagen is essentially dehydrated in cartilage tissue under very high mechanical load, which provides insights into the elastic properties of cartilage collagen, although the mechanical pressures applied here exceed the physiological limit. Copyright © 2006 John Wiley & Sons, Ltd.