Sorocein I, a new Diels-Alder type adduct from Sorocea ilicifolia.
From ethyl acetate extract of the root bark of Sorocea ilicifolia a new ketalized Diels-Alder type adduct, sorocein I (1), was isolated.
A new phenolic glycoside from Sorocea ilicifolia stem bark.
A new phenolic glycoside, 3,4-dimethoxyphenyl-1-O-beta-d-apiofuranosyl (1-->2)-beta-d-glucopyranoside (1), was isolated from the acetone extract of the Sorocea ilicifolia stem bark, along with the known compounds, 3,4,5-trimethoxyphenyl-1-O-beta-apiofuranosyl (1-->6)-beta-d-glucopyranoside, benzyl-O-beta-d-apiofuranosyl (1-->2)-beta-d-glucopyranoside, sorocein A, mulberrofuran K, kuwanon J, sorocein B, chalcomoracin, and kuwanol E.
Stereoselective disposition of ibuprofen enantiomers in infants.
The pharmacokinetics of the enantiomers of ibuprofen were investigated after oral administration of a single 7.6 +/- 0.3 mg kg-1 dose of the racemate in 11 infants. Mean (+/- s.d.) half-lives were 1.6 +/- 0.5 h for S(+) and 1.5 +/- 0.5 h for R(-) and mean (+/- s.d.) AUC values were 31.5 +/- 14.3 mg l-1 h for S(+) and 36.6 +/- 13.8 mg l-1 h for R(-). Since plasma concentrations of the active S(+)-isomer were lower than those reported in adults, a higher dosage might be required in infants.