Enantioselective total synthesis of the indole alkaloid 16-episilicine.
The first total synthesis of (-)-16-episilicine has been completed from a phenylglycinol-derived bicyclic lactam, the key steps being stereoselective conjugate addition and alkylation reactions, and a ring-closing metathesis.
A uniform numbering system for indole alkaloids
Nous proposons un mode uniforme de numérotation pour le squelette des alcaloïdes indoliques complexes. Il est basé sur le fait que tous ces composés sont susceptibles d'être coupés en éléments identiques.
Synthesis and Odor of Chiral Partial Structures of Khusimone. Part 1
Khusimone (1), one of the main odor-donating compounds of vetiver oil is subject of the following study on structure/odor relationship. The omittance of the ethano bridge of the tricyclic khusimone leads to a bicyclic system. The stereoselective approach to this degraded structure is described, and the olfactory properties are studied. The key step of the synthesis of the hydrindane nucleus is based on a highly diastereoselective conjugate addition to a chiral oxo-cyclopentene-2-carboxylate.