Piperidinecarboxamides with potential CNS and cardiovascular properties.
Several 1- and 2-(2-phenylethyl)piperidinecarboxamides were prepared and subjected to preliminary pharmacological studies. Moderate to strong activity by several compounds was observed in modified dopa potentiation tests in mice.
Open-chain analogs of LSD. II. Synthesis of some 2-(3-indolylethyl)- and 2-(3-methyl-2-indolylethyl)piperidines.
Abstract 6-MethyIpyridines substituted in the 3-position, which were quaternized with methyl or ethyl iodide, were condensed under Knoevenagel conditions with 3-indolealde- hyde or with 3-methyl-2-indolealdehyde. The indolylethenylpyridinium iodides thus produced were hydrogenated to the corresponding indolylethylpiperidines. Conversion of the hydrogenation products into acid salts or into quaternary salts provided compounds for pharmacological testing. Some of these are open-chain analogs of LSD.
Über China‐Alkaloide. 8. Mitteilung. Über α‐Oxymethyl‐indole und Indol‐α‐aldehyde. Synthese des α‐(Oxymethyl)‐β‐(2‐oxyäthyl)‐indols, eines Abbauproduktes des Cinchonamins
1. α-Oxymethyl-indole IV, V und VI lassen sich in guter Ausbeute durch Reduktion der entsprechenden Indol-α-carbonsaure-ester I, II und III mit Lithiumaluminiumhydrid gewinnen.