A method for hermetically packing solid medicinal forms
Four basic methods are in existence for protecting solid drugs from external influences: i) coating of tablets with a film by pelleting or in a fluidized bed; 2) packaging preparations in polymeric film materials; 3) packaging in metal foil; 4) packaging in mixed films consisting of aluminum foil and cellophane, polypropylene, or other polymeric material. This method has the widest application at the present time. Methods have been developed not only for packaging in mixed films but also automatic lines of diverse productivity have been established.
Evaluative procedures for filmforming materials used in pharmaceutical applications.
The current interest in films for use in many pharmaceutical applications has motivated a study in which meaningful testing procedures have been developed or adapted for evaluating such films. The testing procedures studied were found to be rapid, efficient, reproducible, and valid for the evaluation of the pertinent properties of several different series of film-forming materials. The studies were conducted on the free films which were cast from these materials. Data gathered on solubility, moisture absorption, water vapor transmission rates, and the effects of temperature, humidity, and light on the free films indicate that the testing methods may be used to predict the effects of these variables on the performance of the films when they are utilized in a dosage form.
Some Relations Between Molecular Structure and Plasticizing Effect
The inter‐relation between the chemical constitution and structure of plasticizers and plastics is discussed. The results obtained with sulfonamide, phthalate and phosphate plasticizers in cellulose acetate compositions are used as examples and the author speculates on the possibility of formulating general rules from such data.