The great war that never was — 1871–1914
Abstract I.F. Clarke concludes his two-part study of the forecasts of future warfare in the half-century before the outbreak of World War I. He argues that the experts failed to foresee trench warfare and the long stalemate on the Western Front, precisely because they were experts, and that the devastating effects of the new military technologies ended the old-style belief in the uninterrupted forward march of mankind.
Oldspeak—the language of the future?
Abstract With this article the series moves on to a two-part examination of the many factors—military, political, technological—that encouraged the new communications industry of the late 19th century to promote the forecasting of future developments. A large part of this publishing was taken up with the popular stories of ‘the next great war’. Their visions of limited and fast-moving wars could not hope to anticipate the shapes of wars-to-come, because they were written in the old language of uniform progress and were grounded in assumptions that advances in the military technologies would speed up the conduct of warfare.
Calyculins and Related Marine Natural Products as Serine-Threonine Protein Phosphatase PP1 and PP2A Inhibitors and Total Syntheses of Calyculin A, B, and C
Calyculins, highly cytotoxic polyketides, originally isolated from the marine sponge Discodermia calyx by Fusetani and co-workers, belong to the lithistid sponges group. These molecules have become interesting targets for cell biologists and synthetic organic chemists. The serine/threonine protein phosphatases play an essential role in the cellular signalling, metabolism, and cell cycle control. Calyculins express potent protein phosphatase 1 and 2A inhibitory activity, and have therefore become valuable tools for cellular biologists studying intracellular processes and their control by reversible phosphorylation. Calyculins might also play an important role in the development of several diseases such as cancer, neurodegenerative diseases, and type 2-diabetes mellitus. The fascinating structures of calyculins have inspired various groups of synthetic organic chemists to develop total syntheses of the most abundant calyculins A and C. However, with fifteen chiral centres, a cyano-capped tetraene unit, a phosphate-bearing spiroketal, an anti, anti, anti dipropionate segment, an α-chiral oxazole, and a trihydroxylated γ-amino acid, calyculins reach versatility that only few natural products can surpass, and truly challenge modern chemists’ asymmetric synthesis skills.