LOW-REYNOLDS-NUMBER INSTABILITY OF THE LAMINAR FLOW BETWEEN WAVY WALLS
Instability of a viscous incompressible flow in a channel with wavy walls is investigated theoretically, numerically and experimentally. Linear stability analysis shows that appropriately chosen wall waviness leads to flow destabilization at surprisingly low Reynolds numbers. The unstable mode of disturbances forms a vortex array, which travels downstream. The remarkable feature is that the most destabilizing waviness does not introduce any additional flow resistance. The outcome of the stability analysis are consistent with the result of direct numerical simulation obtained using CFD finite volume package FLUENT (Ansys Inc.). Preliminary experimental data gained for a channel with appropriately corrugated wall seem to confirm these predictions.
A high-throughput microfluidic real-time gene expression living cell array.
The dynamics of gene expression are fundamental to the coordination of cellular responses. Measurement of temporal gene expression patterns is currently limited to destructive low-throughput techniques such as northern blotting, reverse transcription polymerase chain reaction (RT-PCR), and DNA microarrays. We report a scalable experimental platform that combines microfluidic addressability with quantitative live cell imaging of fluorescent protein transcriptional reporters to achieve real-time characterization of gene expression programs in living cells. Integrated microvalve arrays control row-seeding and column-stimulation of 256 nanoliter-scale bioreactors to create a high density matrix of stimulus-response experiments. We demonstrate the approach in the context of hepatic inflammation by acquiring approximately 5000 single-time-point measurements in each automated and unattended experiment. Experiments can be assembled in hours and perform the equivalent of months of conventional experiments. By enabling efficient investigation of dynamic gene expression programs, this technology has the potential to make significant impacts in basic science, drug development, and clinical medicine.
The Female Face of God in Auschwitz: A Jewish Feminist Theology of the Holocaust
Introduction 1. Reading Post-Holocaust Theology from a Feminist Perspective 2. The Hiding of God's Face in Auschwitz 3. Feminist Intimations of the Holy in Auschwitz 4. Face to Face (with God) in Auschwitz 5. A Mother/God in Auschwitz 6. The Redemption of God in Auschwitz 7. The Princess and the City of Death: A Feminist Maaseh, after Rabbi Nachman of Bratslav. Notes. Select Glossary of Hebrew and Yiddish Terms