Synthesis and evaluation of antimitotic activity of alkylated 2-amino-1,3,4-oxadiazole derivatives.
Series of N-alkylated-2-amino-1,3,4-oxadiazoles (2) were synthesized via alkylation of 2-amino-1,3,4-oxadiazoles (1) under phase transfer condition. This paper also describes the study of antimitotic activity of these molecules by onion root tip method.
Synthesis of 2-amino-1,3,4-oxadiazoles and 2-amino-1,3,4-thiadiazoles via sequential condensation and I2-mediated oxidative C–O/C–S bond formation.
2-Amino-substituted 1,3,4-oxadiazoles and 1,3,4-thiadiazoles were synthesized via condensation of semicarbazide/thiosemicarbazide and the corresponding aldehydes followed by I2-mediated oxidative C–O/C–S bond formation. This transition-metal-free sequential synthesis process is compatible with aromatic, aliphatic, and cinnamic aldehydes, providing facile access to a variety of diazole derivatives bearing a 2-amino substituent in an efficient and scalable fashion.
Mercuric Acetate in Organic Synthesis: A Simple Procedure for the Synthesis of Pyrazolines1
Reaction of aldehyde hydrazones (1) with mercuric acetate leads to the formation of nitrile imines (2) which can react insitu with olefins to produce 1,3,5-trisubstituted 2-pyrazolines (4) in good yield.