Research development of endocrine disrupting chemicals (EDCs) in water in China.
More and more importance has been attached to the problem of endocrine disrupting chemicals (EDCs) since 1960s. This article elaborates the recent research progress of EDCs in water and the trends in the near future in China.
Mutation Effect of Alkyl-hydroxybenzene
The mutation toxicity of the environmental potential endocrine disturbances Alkyl\|hydroxybenzenes has been investigated with Ames test by using the TA97,TA98,TA100 and TA102.The result shows that,except the 2,4-dichlorphenol,the test chemicals such as dimethylphenol,p\|ethylphenol,4\|octanylphenol,nonylphenol,and some chlorophenols have positive responses on the TA98,and the main type of gene mutation is base\|pair frame\|shift.
Synthesis of 2,4-dideoxy-.beta.-D-erythro-hexopyranosyl nucleosides
The synthesis of 1-(2,4-dideoxy-β-D-erythro-hexopyranosyl)thymine (12) 1 was accomplished using two different synthetic routes. It was obtained starting either from 1,2:5,6-di-O-isopropylidene-α-D-glucofuranose or from tri-O-acetyl-D-glucal. The other modified nucleosides, with either a cytosine, guanine, or adenine moiety, were synthesized using the second reaction scheme. Deoxygenation reactions were accomplished with the (2,4-dichlorophenoxy)thiocarbonyl derivatives generated in situ