Artic le Reconquista : I lan Stavans and multicultural ist Latino / a discourse
Ilan Stavans constructs a multiculturalist framework for understanding the US Latino/a experience. By reading The Hispanic Condition (1995) alongside Stavans’ discussions of the Latino/a literary canon in the introductions to his anthologies, New World (1997) and Lengua Fresca (Augenbraum and Stavans, 2006), and his articles in the Chronicle of Higher Education, I argue that this multiculturalist approach is based on an equation of culture with language. Through this linguistic formulation of Latinidad with the Spanish language as its defining facet, Stavans privileges a colonialist rendering of Latino/a history, tracing the ancestral lineage of Latino/as in terms of solely Western European culture. By valorizing Spanish colonization, Stavans glosses over sites of violence in order to highlight a linguistic inheritance and formulates US Latino/a identity in opposition to American indigenous cultures. Uncovering the way in which Ilan Stavans positions the indigenous as Other in his multiculturalist approach to Latinidad is essential to understanding the colonialist and conservative underpinnings of how Stavans structures the Latino/a literary canon. I will consequently address how Latino/a Studies critics have wrestled with Stavans’ influence on the field and the ways in which Stavans’ vision of US Latino/a Studies resembles or reflects its institutional orientation and disciplinary locations. Latino Studies (2009) 7, 410–434. doi:10.1057/lst.2009.42
What Can Latinas/os Learn from Cornel West? The Latino Postcolonial Intellectual in the Age of the Exhaustion of Public Spheres
Because the exile sees things both in terms of what has been left behind and what is actually here and now, there is a double perspective that never sees things in isolation. Every scene or situation in the new country necessarily draws on its counterpart in the old country. Intellectually this means that an idea or experience is always counterposed with another, therefore making them both appear in some new and unpredictable light: from that juxtaposition one gets a better, perhaps even more universal idea of how to think, say, about a human rights issue in one situation by comparison with another. —Edward Said, “Intellectual Exile: Expatriates and Marginals”
Pharmacokinetics and Metabolism of 14C-Brivaracetam, a Novel SV2A Ligand, in Healthy Subjects
This study was designed to investigate the human absorption, disposition, and mass balance of 14C-brivaracetam, a novel high affinity SV2A ligand with potent anticonvulsant activity. Six healthy male subjects received a single p.o. dose of 14C-brivaracetam (150 mg, 82 μCi, or 3.03 MBq). Serial blood and complete urine and feces were collected until 144 h postdose. Expired air samples were obtained until 24 h. Brivaracetam was rapidly absorbed, with Cmax of 4 μg/ml occurring within 1.5 h of dosing. Unchanged brivaracetam amounted to 90% of the total plasma radioactivity, suggesting a modest first-pass effect. Plasma protein binding of radioactivity was low (17.5%). Urinary excretion exceeded 90% after 2 days, and the final mass balance reached 96.8% of the radioactivity in urine and 0.7% in feces. Only 8.6% of the radioactive dose was recovered in urine as unchanged brivaracetam, the remainder being identified as non–cytochrome P450 (P450)- and P450-dependent biotransformation products resulting from hydrolysis of the amide moiety (M9, 34.2%), hydroxylation of the n-propyl side chain (M1b, 15.9%), and a combination of these two pathways leading to the hydroxy acid (M4b, 15.2%). Minor amounts of taurine and glucuronic acid conjugates and other oxidized derivatives were also identified. Brivaracetam is completely absorbed, is weakly bound to plasma proteins, extensively biotransformed through several metabolic pathways, and eliminated renally.