Sesquiterpenes from the leaves of Laurus nobilis L.
Ten sesquiterpenes, together with 12 known compounds were isolated from leaves of Laurus nobilis L. Based on spectroscopic analyses, the 10 compounds were determined to be eudesmane lactones and their corresponding methyl esters. Most of these compounds exhibited moderate-to-significant cytotoxicity towards K562 leukemia cells. One compound had a higher cytotoxicity than doxorubicin, while other compounds had moderate to no activity.
A sesquiterpene alcohol from the fruits of Laurus nobilis
Abstract Besides known sesquiterpene lactones, the fruits of Laurus nobilis gave a germacrane derivative with a rare oxygenation pattern of the isopropyl side-chain.
The absolute configuration of thujane
Abstract (+)- cis - and (+)- trans -Thujane (XIV and XV) have been correlated with (+)-pulegone (IX) via (+)-pulegene (XIII). Using stereospecific reactions, the hydrocarbons of the thujane series have been linked with their oxygenated members. The absolute configurations found by Norin for these substances are in accord with our findings.