A gated electronic switch for stimulation and recording with a single electrode
A circuit design is described for an electronic device which is gate controlled to rapidly switch electrode connections between a stimulator and an amplifier. An integrated switch in the circuit is operated by transistor-transistor logic pulses and will conduct analog signals of up to 15 V amplitude. Electrographic records made using the switch show multi-unit spike discharge after repetitive stimulation of the amygdala in the kindled rat.
Closed-Loop Deep Brain Stimulation for Parkinson’s Disease
Optimal outcomes of deep brain stimulation (DBS) surgery are often an elusive goal. 
 
 
Constant “one-program” stimulation does not reflect the reality of changing clinical symptoms. 
 
 
Closed-loop technology might provide a solution. 
 
 
Closed-loop design will likely integrate multi-sourced sensing data, computed using information from a population database and individual hierarchical paradigms to continuously titrate parameters of stimulation. 
 
 
Proof of principle already exists for the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) primate model and in human Parkinson’s disease (PD) patients. 
 
 
Many elements of such a feedback system have already been developed.
In-House Industrial Production of the Superconducting Conductor for the 43 T Hybrid Magnet of LNCMI-Grenoble
The hybrid magnet being built at LNCMI-Grenoble is based on the combination of resistive inserts, made up of Bitter and polyhelix coils, with a large bore superconducting outsert. It will produce, in the first step, an overall continuous magnetic field of 43 T in a 34 mm warm bore aperture. The superconducting coil will provide a nominal magnetic field of 8.5 T in a 1.1 m cold bore diameter. It relies on the novel development of an Nb-Ti/Cu Rutherford Cable On Conduit Conductor (RCOCC) cooled down to 1.8 K by a bath of superfluid helium pressurized at 1200 mbar. After a brief reminder of the specificity of hybrid magnets, namely the strong electromechanical coupling between resistive and superconducting coils, the main requirements of the RCOCC for efficient and reliable magnet operation are given. The test and validation phases prior to the industrial production of the RCOCC are reported, including the trial production of the ½ hard-drawn (H02 cold-worked) Cu-Ag 0.05% hollow stabilizer in continuous lengths of 325 m. The novelty of the RCOCC development concerns the assembly and the induction soft-soldering of the Rutherford cable on the Cu-Ag hollow stabilizer allowing a strict control of the interstrand contact resistance. Studies, developments, and the integration of the industrial production line at LNCMI-Grenoble are presented together with the result of the production of all RCOCC unit lengths.