PGM18 in two German families
PGMl-isoenzymes with a mobil i ty slower than a seem to be very rare (Hopkinson and Harris, 1966; Giblett, 1969; Yunis, 1969). Fami ly studies were impossible till now. We observed two not related German families with the allele PGM~ (Fig. 1). The pedigrees are shown in Fig. 2. The compilation of all findings in these families (Table) gives no evidence for linkage. We found these two families within al together 2200 PGMl-investigations. Our observation confirms the suggestion, t ha t PGM~ is a rare allele of the phosphoglueomntase.
Genetics and linkage analysis on phosphoglucomutase
The current study is based on 454 families with 843 children from two different areas in Western Germany (Marburg and Tfibingen). Only families which have been especially ascertained for these investigations have been taken into account. For the estimation of the gene frequencies 1449 unrelated persons from the areas mentioned above were investigated in addition to the parents of the family material. Our technique follows Spencer et al. (1964).
Phosphoglucomutase Polymorphism : an Unusual Type in Negroes
PHOSPHOGLUCOMUTASE is present in human erythrocytes in different forms. Spencer et al.1 showed that polymorphism results from the inheritance of two autosomalallelic genes, PGM1 and PGM2. The homozygous state for PGM1 results in pattern 1, for PGM2 in pattern 2, and the doubly heterozygous state results in pattern 2–1. In the English population the gene frequencies for PGM1 and PGM2 are respectively 0.76 and 0.24.