Study on stability of double corsair's main stand
The structure safety is numerically studied on main support of the huge pirate ship by use of finite element method (FEM). In order to the elements meshed successfully, the equivalent treatment is used for the complex structure. The static, structure instability and model analyses are carried out. The static and stability safe coefficient are 6.12 and 19, respectively, which are more than the demand in national standard. The model analysis indicates that the swing frequency is 0.08 Hz, and can be kept off the natural frequency.
Thin-walled structures with slotted connections stability problems
Abstract In this paper the linear and non-linear stability analyses of elastic structures with unilateral supports or connections are presented. Local and global buckling phenomena are analysed for a wide range of columns’ lengths to encounter coupled instability, which appears when local buckling occurs close to global one. Influence of clearances on buckling and post-critical response is examined. This phenomena is illustrated using simplified models, where the clearances are introduced as translation or rotation gaps. Main attention is focused on modelling the double sigma members, where the cross-sections are composed of two sigma members, connected in discrete points distributed along the webs. The influence of spacing and way of numerical modelling of connectors on buckling behaviour of beams is studied. Numerical examples illustrate the importance of proper modelling of the structures with slotted connections accounting for initial imperfections. The examples are solved using FEM.
Rational Design, Synthesis and Evaluation of γ-CD-Containing Cross-Linked Polyvinyl Alcohol Hydrogel as a Prednisone Delivery Platform
This study describes the in-silico rational design, synthesis and evaluation of cross-linked polyvinyl alcohol hydrogels containing γ-cyclodextrin (γ-CDHSAs) as platforms for the sustained release of prednisone (PDN). Through in-silico studies using semi-empirical quantum mechanical calculations, the effectiveness of 20 dicarboxylic acids to generate a specific cross-linked hydrogel capable of supporting different amounts of γ-cyclodextrin (γ-CD) was evaluated. According to the interaction energies calculated with the in-silico studies, the hydrogel made from PVA cross-linked with succinic acids (SA) was shown to be the best candidate for containing γ-CD. Later, molecular dynamics simulation studies were performed in order to evaluate the intermolecular interactions between PDN and three cross-linked hydrogel formulations with different proportions of γ-CD (2.44%, 4.76% and 9.1%). These three cross-linked hydrogels were synthesized and characterized. The loading and the subsequent release of PDN from the hydrogels were investigated. The in-silico and experimental results showed that the interaction between PDN and γ-CDHSA was mainly produced with the γ-CDs linked to the hydrogels. Thus, the unique structures and properties of γ-CDHSA demonstrated an interesting multiphasic profile that could be utilized as a promising drug carrier for controlled, sustained and localized release of PDN.