Procedimentos metodológicos para a elaboração de projetos de pesquisa relacionados a dissertações de mestrado em Ciências Contábeis
This study aimed to distinguish the essential stages in the elaboration of a research project for a master's dissertation in Accountancy. A documentary and bibliographic research was carried out by means of a deductive methodology. It was concludes that the essential stages for the elaboration of an Accountancy master's research project are: a) Title; b) Introduction; c) Problem Characterization; d) (General and Specific) Objectives; e) Relevance; f) Study Delimitation; g) Methodology; h) Literature Review; i) References; j) Timetable, since these represent the basic requirements that qualify a master's project.
INVESTIGAÇÃO DO PERFIL DE PESQUISA DOS ACADÊMICOS DE CIÊNCIAS CONTÁBEIS DA UNIVERSIDADE FEDERAL DE SANTA CATARINA
With the expansion of Accountancy, it becomes essential to the integration of scientific research in teaching as a means of building knowledge and training of critical thinking. Thus, this study investigated the profile of students of Accounting Sciences, Federal University of Santa Catarina (UFSC) in relation to scientific research. The study is descriptive, qualitative and primary source of data. As a result it was found that: only 30% of the students claim to have participated in some forum, lecture or seminar, 46% consider it very important scientific research for those who have claim to follow the academic career (sensu strictu), 65% of the students say the course in Accounting offers no events on what is and how to develop a scientific research, 92% of the students have never participated in any research group accredited by CNPq and coordinated by a professor at UFSC, 84% of the students were encouraged to have contact scientific articles, the teachers of the course, the 47 students who were encouraged to develop scientific article, the most developed one to two articles, among other results. It is concluded that students have a profile related to scientific research, even in its embryonic stage.
Design and synthesis of water-soluble prodrugs of rifabutin for intraveneous administration.
Acinetobacter baumannii is a gram-negative bacterium causing severe hospital-acquired infections such as bloodstream infections or pneumonia. Moreover, multidrug resistant A. baumannii becomes prevalent in many hospitals. Consequently, the World Health Organization made this bacterium a critical priority for the research and development of new antibiotics. Rifabutin, a semisynthetic product from the rifamycin class, was recently found to be very active in nutrient-limited eukaryotic cell culture medium against various A. baumannii strains, including extremely drug-resistant strains, with minimal inhibitory concentrations as low as 0.008 μg/mL. Moreover, this in vitro potency translates into in vivo efficacy. Thus, rifabutin appears to be an attractive novel antibiotic against A. baumannii. In this work, our objective was to design and synthetize rifabutin prodrugs with increased aqueous solubility to allow intraveneous use. Synthetic methodologies were developed to selectively functionalize the hydroxyl group in position 21 and to afford 17 prodrugs. We measured the water solubility of the prodrugs, the stability in human and mouse plasma and their antimicrobial activity against A. baumannii after incubation in human serum. Finally, a pharmacokinetic release study of rifabutin was performed in CD1 mice with three selected prodrugs as a proof of concept.