Methyl 3-(Quinolin-2-yl)indolizine-1-carboxylate
A novel compound, methyl 3-(quinolin-2-yl)indolizine-1-carboxylate (2) has been synthesized by cycloaddition reaction of 1-(quinolin-2-ylmethyl)pyridinium ylide (1) with methyl propiolate in presence of sodium hydride in THF. The structure of this compound was established by IR, 1H-NMR, 13C-NMR and MS data
A Novel Approach for the Synthesis of 5-Pyridylindolizine Derivatives via 2-(2-Pyridyl)pyridinium Ylides.
New 5-pyridylindolizine derivatives (IV) (16 examples) are synthesized via a one-pot three-component reaction using 1,2-butylene oxide as reaction medium and acid scavenger.
Highly enantio- and diastereoselective synthesis of β-methyl-γ-monofluoromethyl-substituted alcohols.
Enanatiopure β-methyl-γ-monofluoromethyl alcohols were prepared from the allylic alkylation between fluorobis(phenylsulfonyl)methane with Morita-Baylis-Hillman carbonates. The reaction was catalyzed by using the Cinchona alkaloid derivative, (DHQD)(2)AQN. The origin of the stereoselectivity was verified by DFT methods. Calculated geometries and relative energies of various transition states strongly support the observed stereoselectivity.