Experiment in relative permeabilities and two-phase transient theory
A series of pressure transients were observed at BR21, a high-enthalpy well. The variation in transient behavior with enthalpy gives some indication of the form of relative permeability functions for fractured media. The consistent form of the observed transients indicates that two-phase transient observations can be used to determine reservoir parameters.
The compressibility and hydraulic diffusivity of a water‐steam flow
Physical parameters are defined for a flow of water and steam in a porous medium: dynamic and kinematic viscosity, density, and compressibility. These permit single-phase pressure transient theory to be applied to two-phase flow provided that the pressure changes are not too large.
Modulation of neuronal serotonin uptake by a putative endogenous ligand of imipramine recognition sites.
Imipramine inhibits the serotonin uptake by binding with high affinity to regulatory sites of this uptake located on axons that release serotonin. The number of imipramine recognition sites located on crude synaptic membrane preparations is reduced by two daily injections of imipramine or desmethylimipramine for 3 weeks. When the binding sites for [3H]imipramine are down-regulated the Vmax of the neuronal uptake of serotonin is increased. Moreover, in minces prepared from the brain hippocampus of rats receiving imipramine in a dose regimen that reduces the number of [3H]imipramine recognition sites, the efficiency of imipramine as a blocker of the serotonin uptake is diminished. Hence the high-affinity binding sites for [3H]imipramine may have a physiological role in modulation of serotonin reuptake. Probably this is mediated by an endogenous effector of these regulatory sites. A nonpeptidic constituent of rat brain capable of displacing [3H]imipramine from its high-affinity binding site and of inhibiting the serotonin uptake in a dose-related manner has been extracted and its partial purification is described.