NMR spectroscopic analysis of 2-mercapto-5-methyl-1,3,4-thiadiazole in cefazolin.
A rapid, sensitive, and accurate method for the quantitative analysis of 2-mercapto-5-methyl-1,3,4-thiadiazole in cefazolin is presented. The method utilizes NMR spectroscopy and is based on the difference in the chemical shift of the methyl protons on free thiadiazole and the thiadiazole moiety of cefazolin.
NMR analysis of pharmaceuticals. X. Determination of methsuximide and phensuximide in capsules.
Abstract A method for the quantitative analysis of methsuximide and phensuximide using NMR is reported. For samples of the pure drugs, results were accurate to 0.3% or less with standard deviations of 0.6% or less. Analysis of capsules of each drug by NMR and NF XIII procedures indicated a maximum difference of 1.5%. but generally the difference was less than 1.0%. This procedure is recommended for the analysis of these drugs since it provides good quantitative results together with a unique spectrum as confirmatory identification.
Determination of meprobamate in tablets by NMR.
A rapid NMR procedure was developed for the analysis of meprobamate tablets with malonic acid as internal standard. An average error of 0.9 percent was obtained on seven synthetic mixtures. The NMR spectrum, in addition, provided a very specific means of identification for meprobamate.