Mass spectrometry of some N-acyldaunosamine derivatives.
Abstract The principal modes of fragmentation subsequent to electron impact of some N -acyl derivatives of daunosamine, the glycoside moiety of the antitumour antibiotics daunomycin and adriamycin, have been studied by using specifically deuterated derivatives and high-resolution measurements. In particular, the elimination of MeOH from methyl β-daunosaminides is shown to occur extensively and stereo-specifically, and involves HO-4. The splitting of the moieties C-1-C-2 and C-5-O-5 affords the fragments D 2 , D ′ 2 , and D ′′ 2 , which are among the most abundant.
Massenspektrometrische untersuchungen—VIII
Zusammenfassung Nach Aufklarung der Zerfallsmechanismen permethylierter Aldopento- und Aldohexopyranoside wird der Einfluss von Aminogruppen auf die Fragmentierungsreaktionen bei Elektronenbeschus gezeigt. Die Massenspektren der permethylierten N-Acetyl-Aminozucker konnen mit den bei der permethylierten Arabinose und Glucose gefundenen Zerfallswegen gedeutet werden. Die Massenspektrometrie gestattet eindeutige Aussagen uber die Struktur von Aminozukkern.
Production of new antituberculosis drug and other medical preparations by electron beam treatment
Abstract Possibility of electron beam usage for immobilization of hydrazidum of an isonicotinic acid (HIA) on dextrane was studied to produce a drug for treatment of a tuberculosis. As a result of irradiation of dextrane the processes of oxidation and formation of polysaccharide occur due to carbonyl groups which are to link isoniasidum. The HIA immobilized on dextrane may be used as an effective medical preparation having prolonged action for action on endo and extracellular population of Micobacterium tuberculosis .