Internal Wave Energy Budget Studies in the South China Sea
Abstract : We are focused on understanding small-scale processes that influence the ocean's thermodynamic and dynamic properties on the sub-mesoscale (scales less than 10 km). This includes the role of turbulence in modifying the upper ocean temperature and density structure. In the South China Sea, large- amplitude, nonlinear waves force turbulence in the seasonally variable continental shelf region. New observational data is sought for use in characterizing turbulence phenomena, and for parameterizing processes in models.
Internal tide and nonlinear internal wave behavior at the continental slope in the northern south China Sea
A field program to measure acoustic propagation characteristics and physical oceanography was undertaken in April and May 2001 in the northern South China Sea. Fluctuating ocean properties were measured with 21 moorings in water of 350- to 71-m depth near the continental slope. The sea floor at the site is gradually sloped at depths less than 90 m, but the deeper area is steppy, having gradual slopes over large areas that are near critical for diurnal internal waves and steep steps between those areas that account for much of the depth change. Large-amplitude nonlinear internal gravity waves incident on the site from the east were observed to change amplitude, horizontal length scale, and energy when shoaling. Beginning as relatively narrow solitary waves of depression, these waves continued onto the shelf much broadened in horizontal scale, where they were trailed by numerous waves of elevation (alternatively described as oscillations) that first appeared in the continental slope region. Internal gravity waves of both diurnal and semidiurnal tidal frequencies (internal tides) were also observed to propagate into shallow water from deeper water, with the diurnal waves dominating. The internal tides were at times sufficiently nonlinear to break down into bores and groups of high-frequency nonlinear internal waves.
An injectable and thermosensitive hydrogel: Promoting periodontal regeneration by controlled-release of aspirin and erythropoietin.
Periodontitis is an inflammatory disease induced by complex interactions between host immune system and plaque microorganism. Alveolar bone resorption caused by periodontitis is considered to be one of the main reasons for tooth loss in adults. To terminate the alveolar bone resorption, simultaneous anti-inflammation and periodontium regeneration is required, which has not appeared in the existing methods. In this study, chitosan (CS), β-sodium glycerophosphate (β-GP), and gelatin were used to prepare an injectable and thermosensitive hydrogel, which could continuously release aspirin and erythropoietin (EPO) to exert pharmacological effects of anti-inflammation and tissue regeneration, respectively. The releasing profile showed that aspirin and EPO could be continuously released from the hydrogels, which exhibited no toxicity both in vitro and in vivo, for at least 21 days. Immunohistochemistry staining and micro-CT analyses indicated that administration of CS/β-GP/gelatin hydrogels loaded with aspirin/EPO could terminate the inflammation and recover the height of the alveolar bone, which is further confirmed by histological observations. Our results suggested that CS/β-GP/gelatin hydrogels are easily prepared as drug-loading vectors with excellent biocompatibility, and the CS/β-GP/gelatin hydrogels loaded with aspirin/EPO are quite effective in anti-inflammation and periodontium regeneration, which provides a great potential candidate for periodontitis treatment in the dental clinic. Statement of Significance To terminate the alveolar bone resorption caused by periodontitis, simultaneous anti-inflammation and periodontium regeneration is required, which has not appeared in the existing methods. Here, (1) the chitosan (CS)/β-sodium glycerophosphate/gelatin hydrogels loaded with aspirin/erythropoietin (EPO) can form at body temperature in 5 min with excellent biocompatibility in vitro and in vivo; (2) The faster release of aspirin than EPO in the early stage is beneficial for anti-inflammation and provides a microenvironment for ensuring the regeneration function of EPO in the following step. In vivo experiments revealed that the hydrogels are effective in the control of inflammation and regeneration of the periodontium. These results indicate that our synthesized hydrogels have a great potential in the future clinical application.