A novel approach to the synthesis of cytotoxic C2-C3 unsaturated pyrrolo[2,1-c]benzodiazepines (PBDs) with conjugated acrylyl C2-substituents.
A concise synthesis of three novel C2-C3 unsaturated pyrrolo[2,1-c][1,4]benzodiazepine analogues (18-20) containing conjugated acrylyl C2-substituents is reported that utilises Heck coupling to install the C2-acrylyl side chains. These analogues possess significant cytotoxicity according to the NCI 60-cell line screen with 18 surpassing anthramycin (1) in potency.
Limitations and factors affecting the lactam reduction approach to the synthesis of anthramycin analogs
Abstract The limitations and factors affecting the hydride reduction of pyrrolo [1,4]benzodiazepine-5,10-diones to anthramycin-type analogs have been explored.
Evaluating Cultural Authenticity in Multicultural Picture Books: A Collaborative Analysis for Diversity Education
This study examines cultural authenticity reflected in multicultural picture books. Specifically, this study attempts to reframe issues surrounding the topic of cultural authenticity based on a systematic and empirical analysis of picture books that represent three different ethnic groups: African Americans, Asian Americans, and Hispanic Americans. A total of forty-five systematically selected picture books that represent fifteen books per ethnic group were selected and evaluated by multiple reviewers who were insiders of the culture. A coding scheme was developed to evaluate each book in terms of profile of major and minor characters, settings of the story, stereotypical features, and cultural authenticity. An in-depth evaluation of all selected books was added by a team of three reviewers in order to validate the results of the coded analysis. This study aims to shed light on library youth services and diversity education in a society with increasing ethnic diversity.