Impact of Excessive Stocks in Process of Bearing Stock Optimization Using Branch and Bound Method
Supply process is one of major priorities for each manufacturing plant. To produce quality products with low prices is an advantage in competition on the market. A prerequisite for such a state is to minimize prices of production inputs, which can be achieved by stock optimizing. Presented contribution on specific example illustrates discrete optimization process on principles of Branch & Bound, which defines the input, and optimized parameters of initial stock of bearings in selected companies operating on Slovak market. In conclusion, the impact of optimized solutions is given and highlights the need for optimization.
Laserowe modyfikowanie materiałów polimerowych. Cz. I. Fizyczne podstawy działania i kryteria doboru laserów
On the basis of literature review the fundamentals of lasers' operation were discussed (Fig. 1 and 2). The general classification of lasers (Table 3, Fig. 3) and the principles of action of two-, three- and four-level lasers (Fig. 4 and 5) were presented. Selected phenomena going in the materials as the results of laser irradiation were described, among others linear and non-linear absorption. The significance of absorption coefficient and laser light reflection coefficient in the processes of modifications of surface layers (WW) of polymeric materials has been stressed (Table 1, Fig. 6). Basic criteria of selection of lasers suitable for this application were given. Possibilities and limitations of lasers in modification of polymeric materials' surface layers have been marked.
Clozapine derived 2,3-dihydro-1H-1,4- and 1,5-benzodiazepines with D4 receptor selectivity: synthesis and biological testing.
Novel 4-arylpiperazin-1-yl-substituted 2,3-dihydro-1H-1,4- and 1H-1,5-benzodiazepines and their aza-analogues were synthesized as debenzoclozapine derivatives for evaluation as potential D4-ligands. While Ki values of some of the title compounds came within the range of clozapine, they showed an impressively greater selectivity over other dopamine receptor subtypes, especially D2. For the most promising compounds, intrinsic activity and binding properties to serotonin 5-HT1A and 5-HT2 were also determined.