Method of evaluation of process of red blood cell sedimentation based on photometry of droplet samples
The paper focuses on research aimed at creating and testing a new approach to evaluate the processes of aggregation and sedimentation of red blood cells for purpose of its use in clinical laboratory diagnostics. The proposed method is based on photometric analysis of blood sample formed as a sessile drop. The results of clinical approbation of this method are given in the paper. Analysis of the processes occurring in the sample in the form of sessile drop during the process of blood cells sedimentation is described. The results of experimental studies to evaluate the effect of the droplet sample focusing properties on light radiation transmittance are presented. It is shown that this method significantly reduces the sample volume and provides sufficiently high sensitivity to the studied processes.
RBC aggregation effects on light scattering from blood
We consider a number of diffusive and transport models of light transmission through whole blood, targeting better understanding of nature of optical transmission pulsations for blood flow modulated by heartbeats. We claim the existence of scattering- associated mechanism rather than the absorption-associated one. Single erythrocytes and their aggregates are considered to be the main centers of scattering in the red- near infrared spectral region. The shape and size of aggregates change in time due to blood flow changes. The corresponding changes of optical transmission are simulated.
Endoscopic treatment of early gastric cancer.
Laser therapy and endoscopic strip biopsy for early gastric cancer are useful measures from our experience. It is considered that the larger lesion of early cancer should be treated by laser therapy and the smaller lesion by strip biopsy. However, endoscopic therapy as a curative treatment still presents problems. Clinical trials with laser therapy has to accumulate to ascertain the effectiveness of laser on the gastric wall. Also, endoscopic treatment methods are limited to patients who cannot be admitted to surgery. Furthermore, it is difficult to judge the metastasis to lymph nodes surrounding the stomach with present diagnostic capabilities. Wider application of these endoscopic treatment methods will follow when these difficulties are overcome.