Alkaloids ofThalictrum collinum
The method of methanolic extraction was applied to the roots. After the methanol has been distilled off, the concentrated extract was treated with 10% sulfuric acid, the acid extracts were alkalinized to pH 9, and the alkaloids were extracted with ether and chloroform. The combined ether-soluble and chloroform-soluble alkaloids obtained were separated into phenolic and nonphenolic bases. The combined nonphenolic tertiary bases were chromat.graphed on a column of alumina (1:70, neutral, activity grade II). The alkaloids were eluted with benzene, benzene--chloroform, chloroform, ethyl acetate, and ethyl acetate-methanol.
Thalictrum alkaloids. V. Isolation.
The experimental procedure which led to the isolation of the new alkaloids thalifendlerine (I), thalifendine (II), thalidastine (III), thaliporphine (IV), preocoteine (V), and thalidezine (VI), from Thalictrum fendleri is described in detail. Known alkaloids also found in T. fendleri are berberine (VII), jatrorrhizine (VIII), glaucine (IX), magnoflorine (X), ocoteine (XI), hernandezine (XII), and thalicarpine (XIII). A completely new dimeric aporphinebenzylisoquinoline alkaloid of only partially elucidated structure is thaldimenne (XIV). A novel procedure for the separation of tertiary alkaloids consists of partition chromatography of the mixture of hydrochloride salts using a cellulose column in the system methyl ethyl ketone–water.
Cooperative Collection Development
The author discusses cooperative collection development from an historical perspective and examines some of the projects conceived and implemented during the past forty years. In many cases the projects failed even after years of concentrated effort. However, more important than these failures are new efforts that are being made. The major focus of this article is on both current regional projects and the more broadly based ARL-sponsored North American Collections Inventory Project. The author discusses these efforts and offers some specific judgments regarding the possibility that these projects will lead to a truly successful coordinated collection development project on a national basis.