Investigation of lactams
The recen t ly developed methods of synthesizing substi tuted 1H,2,3 ,4te t rahydroazepino[3,4-b] indoles [1-3] f rom cap ro l ac t am have opened broad pe r spec t ives for p repar ing condensed lndole de r iva t ives of biological in te res t [4]. In pa r t i cu la r , it became of in te res t to synthesize the indole analogs of such biological ly active compounds as Corazol ( a f t p e n t a m e t h y l e n e t e t r a z o l e ) [5], Omethy lcapro lac t im [6], and also a s e r i e s of 1,2and 10-subst i tu ted azepino[3,4b]indoles for pharmacologica l investigation.
Säureamid‐Reaktionen, XLIII. Über Säureamid‐Dimethylsulfat‐Addukte
Die Dimethylsulfat-Addukte von N.N-Dialkyl- saureamiden, N-alkyl-substituierten cyclischen Amiden sowie von Bis-dialkylamiden einiger Dicarbonsauren werden beschrieben.
One-pot synthesis of annulated pyrido[2,3-d:6,5-d]dipyrimidine derivatives using nitrogen based DBU catalyst in aqueous ethanol medium
Abstract We have reported DBU as an efficient organocatalyst for one-pot three-component synthesis of annulated pyrido[2,3- d :6,5- d ]dipyrimidine derivatives using aromatic aldehyde, thio-barbituric acid and 6-amino-uracil in aqueous ethanol under reflux. The attractive advantages of this process are mild reaction conditions, environment friendly procedure, short reaction times, easy isolation of products, and excellent yields (72–89%).