Antiviral activity of N-phosphorylated amides, thioamides, and their salts
The N-(O,O-dimethylphosphoryl)benzamide (I) was obtained according to [4]; N-(O-methylS-methylphosphoryl)acetamide (acephate) (II) was obtained according to [6], and N-(O,O-diisopropylthiophosphoryl)thiobenzamide (III) (benztriamiph) was obtained according to [7]. The synthesis of N-(O,O-diisopropylthiophosphoryl)thioacetamide (IV), the sodium salt of N-(O,O-dimethylphosphoryl)benzamide (V), and the sodium salt of N-(O,O-diethylphosphoryl)thiobenzamide (VI) is described below.
Dinuclear 3D metal complexes based on a carbacylamidophosphate ligand: redetermination of the ligand crystal structure
Dinuclear Ni(II), Co(II) and Zn(II) complexes of general formula $$ \left[ {{\text{M}}_{ 2}^{\text{II}} {\text{Cl}}_{ 4} \left( {\text{HL}} \right)_{ 4} \left( {\text{i-PrOH}} \right)_{ 2} \cdot 2\left( {\text{i-PrOH}} \right)} \right] $$ with a carbacylamidophosphate ligand, namely 2,2,2-trichloro-N-(dipiperidine-1-yl-phosphoryl)acetamide (CCl3C(O)N(H)P(O)[N(CH2)5]2), were synthesized and characterized by physicochemical and spectroscopic methods. Electronic absorption spectra of the nickel and cobalt complexes were measured at room temperature in toluene and in the solid state. The crystal structures of HL and [Ni2Cl4(HL)4(i-PrOH)2·2(i-PrOH)] have been determined by single-crystal XRD studies. Earlier, the structure of a monoclinic C2/c modification of HL was reported. In this paper, redetermination of the structure of HL with triclinic crystal system, P$$ \overline{1} $$, was made. The nickel complex is a chloro-bridged dimer, in which the Ni(II) centers are in a distorted octahedral geometry and the neutral HL is coordinated via its phosphoryl oxygen atom. This coordination mode was determined for the first time for 3D metal carbacylamidophosphate complexes.
Effect of temperature on the solvated electron in 1-propanol
Abstract The technique of pulse radiolysis has been used to study the effect of temperature on the solvated electron in 1-propanol. The spectrum of the solvated electron has been measured in the range 140–298 K. The wavelength at maximum absorption, λ max , decreases with decreasing temperature (corresponding to an increase in the energy, E max ) but the spectral width at half height, ΔE 1 2 , changes little with temperature. At temperatures above ≈180 K, the formation of the solvated electron is complete at the end of the pulse and its spectrum shows no change in shape with time. Below ≈170 K, the absorption spectrum is time-dependent in both liquid and glassy phases, the changes being attributed to the solvation process. The reaction(s) leading to solvated electron formation following the pulse show an activation energy of 22±2 kJ mol − and the solvated electron decays with an activation energy of 20±2 kJ mol −1 . The yield of solvated electrons decreases continuously with decreasing temperature in the range 298-77 K and, at all temperatures studied, is less than the total ionization yield measured by scavenging techniques.