Statistical optimisation applied to the spectrophotometric study of the tolmetin-Fe(III) complex.
Tolmetin sodium has been examined and determined from dosage forms as its Fe(III) complex and the method has been optimized by statistical optimization.
Orthogonal array design as a chemometric method for the optimization of analytical procedures. Part 5. Three-level design and its application in microwave dissolution of biological samples
The theory and methodology of two-level orthogonal array design for the optimization of analytical procedures were developed. In the theoretical part, the matrix of the two-level orthogonal array design is described while orthogonality is proved by a linear regression model. Then, the assignment of experiments in a two-level orthogonal array design and the application of the triangular table associated with the corresponding orthogonal array matrix are illustrated, followed by the data analysis strategy, in which significance of the different factor effects is quantitatively evaluated by the analysis of variance (ANOVA) technique and the percentage contribution method. Finally, a linear regression equation representing the response surface is established to estimate the factors that have a significant influence. In the application section, microwave dissolution for the determination of selenium in biological samples by hydride generation atomic absorption spectrometry as a practical example is employed to demonstrate the application of the proposed two-level orthogonal array design in analytical chemistry.
Pharmacokinetic studies of tolmetin in man
The pharmacokinetics of the new anti‐inflammatory agent tolmetin have been studied after its oral administration to normal subjects and to patients with rheumatoid arthritis. Plasma concentration‐time data were fitted to a one‐compartment open model. Following single oral doses, no basic differences in rates of drug absorption and elimination were found between normal subjects and arthritic patients. For the 12 subjects studied, the overall mean elimination rate constant was 0.839 hr‒1, corresponding to a plasma half‐life of 0.83 hr. The drug was rapidly absorbed and had a mean apparent volume of distribution of 0.098 1/kg. Plasma levels and pharmacokinetic parameters of tolmetin in arthritic patients after multiple dosing were similar to those after a single dose.