Three dimensional packaging and interconnecting techniques for microwave modules
Three dimensional (3D) packaging and interconnecting techniques can greatly reduce the weight and volume of conventional planar microwave modules. The objective of this study was to employ a novel 3D structure with simple manufacturing process to develop 3D microwave modules. Many advanced 3D packaging and interconnecting methods, such as LTCC microwave multichip modules, vertical interconnects, and 3D electromagnetic field analyzing and optimizing, were applied to increase the package density and improve the electric performance. Test method and test results of 3D microwave modules were introduced. These techniques are very useful to many types of modern active phased array radar systems and communication systems.
Advanced interconnecting techniques of integrated T/R modules
The basic requirements for transmit/receive(T/R) modules of active phased array radar systems are small volume and light weight with excellent microwave performance and uniformity. The objective of this study was to employ new interconnecting techniques to develop high density, integrated T/R modules. Many advanced interconnecting methods were applied to increase the package density and improve the electric performance. High density, integrated T/R modules with good microwave performance and uniformity were manufactured successfully. These techniques are very useful to many types of modern active phased array radar systems.
BIOSYNTHESIS OF DAUNORUBICIN GLYCOSIDES: ANALYSIS WITH BLOCKED MUTANTS
ABSTRACT Daunorubicin (daunomycin; NSC 82151) is an anthracycline antibiotic that is useful in the treatment of human leukemias. Several Streptomyces species accumulate higher glycosides of daunorubicin, which can be converted to daunorubicin by simple hydrolysis. We isolated a number of mutants of a daunorubicin glycoside-producing streptomycete, and found that some were deficient in accumulation of daunorubicin glycosides. One such mutant accumulated no detectable anthracyclines, while other mutants accumulated anthracyclines or aglycones that have not been reported before or have been described as co-metabolites of daunorubicin glycosides. Some of these anthracyclines and aglycones were purified and used as substrates in bioconversion experiments with various mutants. The results allowed us to construct a proposed pathway for the biosynthesis of daunorubicin glycosides by this streptomycete. KEYWORDS Anthracycline; daunorubicin; biosynthesis; blocked mutants; biotransformation.