Cycloartanes from the red alga Galaxaura sp.
Six cycloartane triterpenes have been isolated from the red alga Galaxaura sp. The new structures (galaxaurols A–E) were determined to be methyl 3β-hydroxy-23-oxocycloart-24-en-29-oate (2), methyl 23(E)-3β-hydroxy-25-methoxycycloart-23-en-29-oate (3), methyl 23(E)-3β-hydroxycycloarta-23,25-dien-29-oate (4), 23(E)-25-methoxycycloart-23-en-3β,29-diol (5), and cycloart-24-en-3β,23α,29-triol (6), respectively.
New cytotoxic cycloartane triterpene from Cassia italica aerial parts
Phytochemical study of the aerial parts of Cassiaitalica Mill. (family: Fabaceae) growing in Saudi Arabia afforded one new cycloartane triterpene, named (22E)-3-β-hydroxycycloart-22-en-24-one (2), together with eight known compounds: β-sitosterol (1), uvaol (3), daucosterol (4), methyl 3,4-dihydroxybenzoate (5), emodin (6), 4-hydroxypheny-O-β-D-glucopyranoside (7), aloin (8) and rutin (9). The structure of the isolated compounds was determined by physical, chemical and spectral data (UV, IR, MS, 1D (1H, 13C and DEPT) and 2D (1H–1H COSY, HSQC and HMBC) NMR), as well as by comparing with authentic samples. Compounds 3–5 and 7–9 were isolated for the first time from the plant. Compound 2 was evaluated for its cytotoxic activity against the L5178Y and PC12 cell lines. The total methanolic extract and compounds 5–9 exhibited free radical-scavenging activity using DPPH assay.
Composition en stérols de végétaux marins méditerranéens
INTRODUCTION M. C. !atrides\ J. Artauda, N. Vicenteb. a Institut Universitaire de Technologie, rue des Geraniums, 13337 Marseille Cedex 14, et Laboratoire des Organo-Phosphores, Universite d'Aix-Marseille-III, 13397 Marseille Cedex 14. b Laboratoire de Biologie marine, Universite d'Aix-Marseille-III, 13397 Marseille Cedex 14. Recu le 7/6/82, revise le 19/8/82, accepte le 23/8/82. La composition en sterols de diverses algues et phanerogames marines mediterraneennes a ete determinee : Rissoel/a. verruculosa (Rhodophycee) est riche en cholesterol et desmosterol alors que Halopteris scoparia, Cystoseira stricta et Padina pavonica (Pheophycees) possedent du fucosterol en majorite. La composition d'U/va /actuca (Chlorophycee) est conforme a ce que l'on connaissait anterieurement puisqu'elle contient du .15-avenasterol a plus de 90 %. Pour toutes ces algues les sterols mineurs ont ete determines. Posidonia oceanica et Cymodocea nodosa (Phanerogames) ont une composition en sterols caracterisee par du 13-sitosterol et du stigmasterol principalement. De petites quantites de cholesterol, campesterol, .15-avenasterol sont aussi mises en evidence. Oceanol. Acta, 1983, 6, 1, 73-77. Sterol composition of Mediterranean marine plants. The sterol composition of various Mediterranean marine algae and phanerogams has been determined. Cholesterol and desmosterol are major constituents of Rissoella verrucu/osa (Rhodophyceae) and fucosterol is the main component of Halopteris scoparia, Cystoseira stricta and Padina pavonica (Pheophyceae). As expected, Ulva lactuca (Chlorophyceae) contains more than 90% .15-avenasterol. In ali these algae the minor sterols have been analysed. The sterol composition of Posidonia oceanica and Cymodocea nodosa (Phanerogams) consists essentially of 13-sitosterol and stigmasterol and certain amounts of cholesterol, campesterol, .15-avenasterol have also been found. Oceano/. Acta, 1983, 6, 1, 73-77. L'etude de la composition en sterols d'un certain nombre d'algues marines a ete precedemment utilisee a leur chimiotaxonomie. al., 1980) de preciser, dans un certain nombre d'especes d'algues, les sterols mineurs presents a cote des sterols majoritaires. Ainsi chez les algues, le fucosterol caracterise les Pheophycees, le cholesterol les Rhodophycees, alors que les Chlorophycees presentent souvent une composition sterolique complexe sans sterol caracteristique. L'application de methodes chromatographiques modernes nous a permis dans un precedent travail (Artaud et 0399-1784!1983/73/S 5.00/ ~Gauthier-Villars 73 Les vegetaux marins mediterraneens n'ayant pas jusqu'a present fait l'objet de travaux particuliers, ce travail a pour but de determiner la composition sterolique de differentes especes d'algues mediterraneennes en vue de confirmer leur taxonomie et celle de deux especes de plantes superieures vivant dans le meme biotope et pour lesquelles il n'existe pas de donnees anterieures. M. C. !ATRIDES. J. ARTAUD. N. VICENTE PARTIE EXPERIMENTALE