Natural diaryl ethers
In this review, on the basis of an analysis of voluminous literature material on natural phenolic compounds belonging to various structural types, the interrelationship between the dimeric molecules formed as the result of the oxidative coupling of the corresponding monomeric compounds is considered.
The Oxidation of 3,5-Diiodotyrosine to Thyroxine.
A physiologically active protein product from which thyroxine (IV) can be isolated was prepared from milk casein by W. Ludwig and P. von Mutzenbecherl in 1939, by treatment of this protein with iodine under carefully controlled conditions. The experimental technique of these workers was repeated by C. R. and Rosalind V. P. and the original findings of the German investigators were confirmed in every respect.
Second-Generation Process Research Towards Eletriptan: A Fischer Indole Approach
The development of a second-generation process for the synthesis of eletriptan via a Fischer indole cyclisation is described. The finalised process offers several potential advantages over the current route of manufacture including cost, throughput, and safety.