Investigation of wood properties that influence the final moisture content of air-dried sugi (Cryptomeria japonica) using principal component regression analysis
Sugi (Cryptomeria japonica D. Don) lumber is known to have a large variability in final moisture content (MCf) and is difficult to dry. This study investigated the variability in MCf of sugi in relation to wood properties. The wood property variables included initial moisture content (MCi), basic density (BD), annual ring orientation (ARO), annual ring width (ARW), heartwood ratio (HR) and CIE L* color (L*). Sugi samples were cut from flat-sawn lumbers and air-dried; a principal component regression (PCR) model for predicting MCf was developed with the wood property variables. The wood properties that contributed to the prediction of MCf were evaluated by PCR analysis. Significant positive regression coefficients of the PCR model were observed in the MCi, BD, ARO and HR, whereas negative ones in the L*. There were no significant regression coefficients in the ARW. These results suggest that the MCi, BD, ARO and HR had a positive influence, the L* had a negative influence, and the ARW had little influence on the MCf of air-dried sugi wood. This finding is in line with the general view on the drying characteristics in relation to these wood properties.
EFFECTS OF SAWING PATTERN ON LUMBER DRYING: MODEL SIMULATION AND EXPERIMENTAL INVESTIGATION
ABSTRACT The sawing pattern of lumber affects the drying rate due to transverse permeability differences. These permeability differences are considered in a single board drying model which is able to investigate the drying rates for boards with varying growth ring angles. For the drying of Pinus radiata lumber, the model predicts that the quartersawn boards need longer drying time than the flatsawn boards. The drying time difference was 10–15% of the total drying time for conventional temperature (CT) drying and accelerated conventional temperature (ACT) drying, but was less significant for high temperature (HT) drying. In the simulation of a kiln stack drying, a sawing pattern factor was introduced to the relative drying rate function, which reflected the effects of the growth ring angle and the drying temperatures. The modified kiln wide drying model was used to predict the drying rates for a kiln stack consisting of entirely flatsawn boards and a kiln stack consisting of entirely quartersawn boards. Drying tests were conducted using stacks of mixed flatsawn and quartersawn Pinus radiata sapwood boards. In the tests, three drying schedules were used which included CT, ACT and HT drying. The experimental results agree closely with the model predictions and thus, after further validation, the drying models can be used to predict commercial kiln drying of boards with different sawing patterns.
Improved Skin Penetration Using In Situ Nanoparticulate Diclofenac Diethylamine in Hydrogel Systems: In Vitro and In Vivo Studies
Delivering diclofenac diethylamine transdermally by means of a hydrogel is an approach to reduce or avoid systemic toxicity of the drug while providing local action for a prolonged period. In the present investigation, a process was developed to produce nanosize particles (about 10 nm) of diclofenac diethylamine in situ during the development of hydrogel, using simple mixing technique. Hydrogel was developed with polyvinyl alcohol (PVA) (5.8% w/w) and carbopol 71G (1.5% w/w). The formulations were evaluated on the basis of field emission scanning electron microscopy, texture analysis, and the assessment of various physiochemical properties. Viscosity (163–165 cps for hydrogel containing microsize drug particles and 171–173 cps for hydrogel containing nanosize drug particles, respectively) and swelling index (varied between 0.62 and 0.68) data favor the hydrogels for satisfactory topical applications. The measured hardness of the different hydrogels was uniform indicating a uniform spreadability. Data of in vitro skin (cadaver) permeation for 10 h showed that the enhancement ratios of the flux of the formulation containing nanosize drug (without the permeation enhancer) were 9.72 and 1.30 compared to the formulation containing microsized drug and the marketed formulations, respectively. In vivo plasma level of the drug increased predominantly for the hydrogel containing nanosize drug-clusters. The study depicts a simple technique for preparing hydrogel containing nanosize diclofenac diethylamine particles in situ, which can be commercially viable. The study also shows the advantage of the experimental transdermal hydrogel with nanosize drug particles over the hydrogel with microsize drug particles.