Short total syntheses of both the putative and actual structures of the clerodane diterpenoid (+/-)-sacacarin by double annulation.
[reaction: see text] The putative structure of the naturally occurring clerodane diterpenoid (+/-)-sacacarin has been prepared in only 10 steps, six of which are C-C bond-forming steps, in a chemo-, regio-, and diastereoselective manner. The key part of the synthesis is the double annulation (double Michael, Pinner, and Dieckmann reaction) of a tethered carbon diacid and 3-butyn-2-one. A corrected structure for sacacarin is proposed, and the structure is proven by synthesis.
Investigations into the total synthesis of insect antifeedant clerodanes. The total synthesis of +/- 4-epi ajugarin
Abstract Starting from alcohol 3 , a stereospecific synthesis of carboxylic acid 2 is described. This acid 2 is a key intermediate in the total synthesis of ajugarins and its conversion into ± 4-epi ajugarin is reported.
Problems of a centralised department in a decentralised mental hospital.
Abstract This paper deals with some of the issues and problems which arose in a state mental hospital, when in the course of becoming a more community-oriented facility, the hospital decentralized its clinical structure into geographically-based treatment units while retaining a centralized nursing department administration. The effects of unitization and a subsequent attempt to reoganize the nursing department on both the character of professional roles and the integration of parts of the hospital are discussed within the context of an open-systems conceptual model of hospital organization.