THE NATURE OF MIGRAINE
It was, therefore, also with some hesitation that I accepted the invitation, humbly realizing that I can bring my audience nothing new, and when now, I nevertheless venture to try to speak about the nature of migraine seen from my point of view after a long life of work with migraineological problems, I do it to a very limited extent only on the basis of my own experience, but first and foremost because I base my opinion on the facts with which friends and colleagues have enriched our knowledge through their research, not only through numerous literary publications and lectures, but also and not least through the answers to personal inquiries which I have received with thanks in the course of time.
Headache: Diagnosis and Treatment
the recto-sigmoid, the acceptanceof the risk of pyremic emboli to the liver in order to reducethe period of incapacity by immediate hsemorrhotdectomyin patientswith 'prolapsed thrombosed internal heemorrhotds,and the preference for suprapubicrather than retropubic prostatectomy. Although the disadvantagesof the perineal method of prostatectomy are given, it is of note that its technicaldetails are described in full with nine illustrations, whereasonly two inadequate illustrations of' the retropubic method are included. Despite these minor criticisms, this would appear to be one of the best standardworks on operative surgery, and it can be thoroughly recommendedto all who require such a book for systematicpost-graduatestudy or as a reference book when details of an unfamiliar operation are required. 'J5ookS mecei\lelJ.
Effects of methysergide on platelets incubated with reserpine
1 Platelets were incubated with methysergide and related compounds (2‐bromo lysergic acid (BOL), ergotamine and methyl ergotamine) together with reserpine. 2 Methysergide inhibited the normal aggregation response of platelets to 5‐hydroxytryptamine (5HT) but did not affect the reduction in the 5HT content caused by reserpine, or the uptake of 5HT by the platelets. 3 BOL, ergotamine and methyl ergotamine behaved similarly. Methysergide had greater anti5HT potency than BOL, and methyl ergotamine had greater potency than ergotamine. 4 The use of platelets as a model for synaptic preparations is discussed. 5 The role of 5HT receptor sites on the platelet membrane and the significance of the results for migraine patients treated with methysergide are discussed.