The structure of regalamine
SummaryOn the basis of UV, IR, NMR, and mass spectra and chemical transformations the structure of 11,12-dihydroxy-2-methoxy-1,12-epoxyhexahydrohomoproaporphine has been proposed for regalamine.
Alkaloide Von Bulbocodium vernum L Inhaltstoffe der Liliaceae‐Wurmbaeoideae. 75. Mitteilung
From whole plants of Bulbocodium vernum L. the flavone luteoline (I) and the alkaloids colchicine (II), N-formyl-N-deacetylcolchicine (III), 3-demethylcolchicine (V), (+)-bulbocodine (IX) and (−)-kreysigine (XI) were isolated in crystals. The presence of 2-demethylcolchicine (IV), s- (VII) and γ-lumicolchicine (VIII), demecolcine (VI) and five not identified alkaloids was demonstrated by thin-layer chromatography. On the basis of ultraviolet, infrared and mass spectra, PMR.-analysis (Overhauser effect), and circular dichroism, the (6a-R, 8a-S)homo-proaporphine structure IX, with one methoxy group at C-2, has been assigned to (+)-bulbocodine. The (6a-R)-structure (XI) was deduced for (−)-kreysigine by comparing its optical rotation and circular dichroism which the values of (−)-multifloramine (X), the structure of which is known.
Role of the coronoid process in varus osteoarticular stability of the elbow.
The role of the coronoid process in varus osteoarticular stability of the elbow was investigated in 10 cadaveric elbows. Testing was performed at multiple flexion angles after incremental removal of the coronoid. At each flexion angle, removal of more than 50% of the coronoid produced a statistically significant decrease in the load resisting varus displacement compared with all lesser resection levels (P < .003). There was a trend for decreasing load after removal of 50% of the coronoid. The mean decrease in load across all flexion angles was 10.1%, 50.4%, and 75.4% after removal of 50%, 75%, and 100% of the coronoid, respectively. Resistance to varus displacement tended to decrease more as a percent of control at lower flexion angles than at higher flexion angles after removal of more than 50% of the coronoid. The coronoid process was found to be a key varus stabilizer in the elbow and may contribute more to elbow stability in extension than in flexion.