An Efficient and Chemoselective Procedure for Acylal Synthesis
A novel heterogeneous efficient procedure has been developed for the chemoselective synthesis of acylals (1,1-diacetates) under solvent-free conditions. A novel catalyst prepared by the sulfuric acid catalyzed copolymerization of p-toluenesulfonic acid and paraformaldehyde displays extremely high activities for the title reactions, affording average yields over 90% within several minutes. A comparative study showed that the novel catalyst has much higher activity than other catalysts used for this purpose. Besides, the novel catalyst displays chemoselectivity for the protection of aldehydes in the presence of ketones. In addition the high acidity (4.0 mmol/g), thermal stability (200 ºC) and easy reusability make the novel catalyst one of the best choices for the process.
Conversion of corn stalk into furfural using a novel heterogeneous strong acid catalyst in γ-valerolactone.
A novel solid acid catalyst was prepared by the copolymerization of p-toluenesulfonic acid and paraformaldehyde and then characterized by FT-IR, TG/DTG, HRTEM and N2-BET. Furfural was successfully produced by the dehydration of xylose and xylan using the novel catalyst in γ-valerolactone. This investigation focused on effects of various reaction conditions including solvent, acid catalyst, reaction temperature, residence time, water concentration, xylose loading and catalyst dosage on the dehydration of xylose to furfural. It was found that the solid catalyst displayed extremely high activity for furfural production. 80.4% furfural yield with 98.8% xylose conversion was achieved at 170°C for 10 min. The catalyst could be recycled at least five times without significant loss of activity. Furthermore, 83.5% furfural yield and 19.5% HMF yield were obtained from raw corn stalk under more severe conditions (190°C for 100 min).
A study of the local tissue reactions in man to cortisone and compound F. VI. Histopathological studies of the local effect of compound F in normal and pathologic skin of man.
After our previous negative studies (1) of the local effect of cortisone acetate in the skin of man, a year ago, a parallel study of 17-hydroxycorticosterone-21-acetate, Compound F, was outlined. Theoretically, Compound F should be the active steroid. It was so suggested by Rothman (2), that in all probability Compound F and not cortisone would be active locally in the skin of man.