Is it Time to Rewrite the Constitution? Fidelity to Our Imperfect Constitution
This essay considers arguments that the U.S. Constitution is so imperfect — and the constitutional and political system so dysfunctional or otherwise failing — that it is time to rewrite the Constitution through amendment or constitutional convention. I argue that if we adopt and maintain an attitude of fidelity to our imperfect Constitution, it may be unnecessary to formally amend the Constitution unless there is good reason to believe that something better might come out of this process. The better approach is to maintain an attitude of fidelity to the imperfect Constitution and to apply a Constitution-perfecting theory — to interpret the Constitution so as to make it the best it can be. Furthermore, maintaining that attitude, we should recognize the need to “rewrite” the constitutional culture the better to secure constitutional democracy: to cultivate the civic virtues and foster the capacities needed to maintain constitutional self-government.
The Rights Retained By The People The History And Meaning Of The Ninth Amendment
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Thorium-induced Anatomical and Histopathological Changes in Liver of Swiss Mice
ObjectivePresent study is aimed to investigate the anatomical and histopathological changes in liver tissues of Swiss albino male mice, one month after intravenous administration of thorium (232Th; 4 and 40 mg/kg).MethodsSynchrotron X-ray micro-CT imaging, CD31 immuno-cytochemistry, hematoxylin & eosin staining and Periodic acid-Schiff staining were performed to study changes in liver anatomy, blood vessels/capillaries, histology and glycogen content of liver, respectively.ResultsSynchrotron X-ray micro-CT imaging of liver showed loss of blood vessels in mice treated with thorium (4 mg/kg), which was more prominent at higher dose of thorium (40 mg/kg). These thorium-induced changes in liver were correlated with the decrease in CD31 positive cells and loss of tissue architecture. A dose-dependent increase in glycogen content was also observed in the liver of thorium-treated mice.ConclusionOur results provide novel insight about the effects of thorium on liver, which may have significant implications in understanding the mechanism of thorium thorium-induced hepatotoxicity.