Statistical optimisation applied to the spectrophotometric study of the tolmetin-Fe(III) complex.
Tolmetin sodium has been examined and determined from dosage forms as its Fe(III) complex and the method has been optimized by statistical optimization.
Micro-determination of tolmetin in plasma by electron-capture gas chromatography.
A highly sensitive, specific and precise gas chromatographic method for the determination of the anti-inflammatory agent tolmetin in micro-samples of blood plasma is described. The pentafluorobenzyl ester derivative of tolmetin, which can be detected down to picogram levels using electron-capture detection, has been prepared. The lowest concentration of tolmetin which can be measured accurately and precisely (coefficient of variation less than 15%) in a 25-microliter plasma sample is 0.1 microgram/ml. Previously reported assays require a sample size 20--80 times larger and have a detection limit of 0.5 microgram/ml. The pentafluorobenzyl ester derivatives of both tolmetin and the internal standard have been identified from their chemical ionization mass spectra. The present method was found to be in good agreement with another published gas chromatographic assay when both methods were employed to analyze the same set of plasma samples from four juvenile reheumatoid arthritic patients.
Creativity profile of university and conservatory dance students.
What are dance students' creative potential, Special personality characteristics and preferences for high energy activities? Using standardized and original paper and pencil instruments, comparisons were made among dance students in university and conservatory settings, college students and art students. The results demonstrated that dance students are creative, show strong preference for dynamic figures, and have distinct personality characteristics. The university dance students differed from the conservatory students in several important ways.