Spectral/target activity of short lived radio isotope in pulsed plasma accelerator.
Accelerated deuteron spectra from magnetic spectrometry and graphite bombardment by such deuterons were used to produce short-lived radionuclides in NX2 plasma focus. The experiments show one order of magnitude difference between the activity generated by these techniques. The average activity of NX2 is 5.2 kBq and the highest activity for the best shot is about 40 kBq.
Short-Lived PET Radioisotope Production in a Small Plasma Focus Device
High-energy deuterons from a small plasma focus device (1.7 kJ) have been used for short-lived radioisotope production. For the 12C(d, n)13N reaction, 40 kBq of 13N was obtained by bombarding a graphite target at a 1-Hz shot repetition rate for 30 s. This could be increased to 10 MBq at a 16-Hz repetition rate. Plasma focus devices operating with higher bank energies should produce substantially higher isotope yields.
Fungal Biotransformations in Pharmaceutical Sciences
The regio- and stereoselective conversion of complex substrates represents one of the major advantage of microbial biotransformation. This chapter covers the biocatalytic capacities of fungi to derivatize bioactive small molecules, both from natural sources and from synthetic compounds. We focus particularly on sterol and taxane biotransformation. We also present examples at the interface of biotransformation and pathway engineering using recombinant organisms, with an emphasis on the production of lovastatin derivatives. Finally, we highlight selected studies on fungal xenometabolism which serves as a model to study the breakdown of drugs in mammals.