Mathematical Representation of Friction in Metal Forming Analysis
As recently stressed by Kalpakjian [1]. Schey [2] and many other authors [3-8] the development is an improved friction model is an important topic in metal farming analysis. In the present study a fresh friction approach is suggested. It connects the friction shear stress not only with the normal stress but also with the relative displacement between tool and workpiece and the relative surface increase. The model presented is based on the physical conception of the friction phenomenon as described by Schey [2.4″], Wanheim, [7] and Dautzenberg [8, 9]. Connections with the well known Coulomb model (T Fr = up) and the so called constant friction model [T Fr = m J F /✓3 and discussed. Theoretical findings are verified with experimental data from different tests. Although a few questions are still open, some progress in technical understanding of friction in forming tools could be achieved.
Improvement of the Plane-Strain Compression Test for Determining Flow Curves
Summary The plane-strain compression test can be applied for determining flow curves up to high-strains. In order to improve the accuracy of the test the use of dies with rounded edges was studied both theoretically and by experiments. The effects of influencing factors were studied and the actual effective area of the dies and the coefficient of friction were determined. The flow curve is determined by eliminating the contribution of friction and shear deformation from the resistance to deformation using the methods of elementary plastomechanics.
Pharmacokinetics of amikacin and chloramphenicol in the aqueous humor of rabbits
Composite data describing ocular pharmacokinetics are unreliable because of intersubject variation. To address this problem, an animal model was developed in which multiple aqueous samples from single subjects were obtained. Following direct anterior chamber or intravenous administration of amikacin or chloramphenicol, pharmacokinetic analysis of drug concentrations in the serum and anterior chamber was performed by using a nonlinear least-squares regression program. The number of anterior chamber paracenteses performed did not alter the beta elimination rates or percent penetration into the anterior chamber. The aqueous humor and peripheral-compartment terminal slopes were identical. These data indicate that complete ocular concentration-time curves can be obtained without altering antibiotic pharmacokinetics. Following direct injection into the anterior chamber, the elimination rates for both antibiotics followed a one-compartment model, whereas those following intravenous administration best fit an open, first-order, two-compartment model. Following intravenous administration, the anterior chamber elimination rate constants for both drugs were equal to that of the serum and significantly longer than that following direct injection. The elimination rates of both drugs following direct injection were similar. Systemic administration resulted in drug levels in aqueous humor that persisted longer than those following direct injection. Chloramphenicol, a lipophilic compound, gave higher mean concentrations in aqueous humor than did amikacin. Our model provides a new approach which rigorously examines ocular pharmacokinetics and provides data which suggest that for selected compounds the parenteral route of administration is preferable.