Chemical Constituents Of Mitrella Kentii ( Annonaceae ) Ainnul Hamidah
Abstract: Mitrella kentii which belongs to the Annonaceae family is a tree-climbing liana found in the Malaysian Peninsula, Islands of Sumatra, Borneo, and New Guinea. This species was studied in 1972 for their alkaloids, 1997 and 2012 for their non-alkaloid constituents. In this study, chalcones, Desmosdumotin C (1) and their tautomer, 2-cinnamoyl3-hydroxy-5-methoxy-4,6,6-trimethylcyclohexa-2,4-dienone (2), flavanone, 7-hydroxy-5,6-dimethoxy-2-phenylchroman4-one (3), oxoaporphine alkaloids, Liriodenine (4) and Atherospermidine (5) and also terpenoid, -Sitostenone (6) have been isolated from this species. All these compounds were isolated for the first time from Mitrella kentii except Liriodenine (4). The isolated compounds were elucidated using spectroscopic techniques such as UV, IR,1D and 2D NMR and mass spectroscopy and by comparison their spectral data with those previously reported in the literatures. Desmosdumotin C (1) showed the anti-ulcer activity.
Desmosdumotin C, a novel cytotoxic principle from Desmos dumosus
Abstract The structure of desmosdumotin C ( 1 ), a novel compound isolated from the roots of Desmos dumosus, has been established from spectral data and X-ray crystallographic analysis. Significant and selective in vitro cytotoxicity of 1 was found against bone (HOS), breast (MCF), and ovarian (IA9) cancer cell lines.
Chemical, physical and antimicrobial properties of essential oils of Leptospermum scoparium and Kunzea ericoides.
The major components of commercial New Zealand essential oils of Leptospermum scoparium (manuka) and Kunzea ericoides (kanuka) are identified. In the manuka oil, monoterpenes are present at low levels (< or = 3%). Sesquiterpene hydrocarbons are predominant (> or = 60%) and include groups possessing cubebene/copaene, elemene, gurjunene/aromadendrene, farnesene/ caryophyllene, selinene, calamenene and cadinene skeletons. Oxygenated sesquiterpenes and triketones are present (< or = 30%). The antimicrobial activity of the manuka oil was associated with a fraction containing three major and three trace triketones, two of the latter were previously unreported. Kanuka oil was characterized by high levels of alpha-pinene (> 50%) and lower levels (< 10%) of viridiflorol and viridiflorene. GC-MS and GC-FID detector responses to the same components were noticeably different for some major components, including the triketones. Non-commercial manuka oils from different sites differed widely in composition and could be separated into four groups by the presence and levels of distinctive components. The density and refractive index of manuka and kanuka oils were closely correlated with the total sesquiterpene levels. The density of the commercial manuka oil was closely correlated with the level of the triketones. Simple density measurements enabled discrimination between the commercial oil and oils from other sites, and prediction of antimicrobial activity.