Multi-Scale Modelling of Textile Reinforced Tissue Engineered Heart Valves
Transcatheter aortic valve implantation of fibrin-based tissue engineered heart valves with a tubular leaflet construct have been developed as an alternative to invasive traditional surgical heart valve implantation, but currently need reinforcement to withstand pressures found in the aortic position. To increase valve strength, a PET textile reinforcement has been introduced to the fibrin scaffold. However, care must be taken when using a textile reinforcement. Increasing reinforcement may increase the strength, but also increases stiffness which can interfere with the functionality of the valve, prohibiting full valve closure. In order to predict the behavior of the valve, improve design, and eventually optimize valve performance by tailoring the textile reinforcement, a 4-tiered hierarchical multi-scale modelling framework has been created. The model includes an individual fiber scale model, two textile-level models, and a full heart valve model. Geometry generation based on microscopic images of the composite will be discussed, along with application of boundary conditions and loading application. Fitting the various material models based on homogenization of the smaller scale will be demonstrated. Finally, experimental validation and characterization at various scales will be discussed.
A temporarily stented, autologous pericardial aortic valve prosthesis.
BACKGROUND AND AIM OF THE STUDY
A new bioprosthesis has been developed that is: (i) constructed from glutaraldehyde-treated autologous pericardium due to its lack of antigenicity and low cost; (ii) easily constructed in the operating room; (iii) stentless but easy to implant by using a temporary stent that is removed once its function is no longer necessary; and (iv) implanted with a single proximal suture and three commissural stitches.


METHODS
This prosthesis was implanted in the subcoronary aortic position of six sheep. The mean prosthesis size was 19.7 +/- 3.5 mm, and manufacturing time 16 +/- 3 min. Cardiopulmonary bypass and cross-clamp times were 142.5 +/- 26.7 min and 100.2 +/- 28.8 min, respectively. Three sheep were euthanized at three, seven, or 27 days, and the remainder at five months postoperatively.


RESULTS
In all cases the valve was competent and the single commissural stitches were well-anchored. The pericardium was pliable in all cases, but one animal had obvious endocarditis (at 27 days). Small calcific nodules were found at the commissures in valves explanted at five months. Histology showed an intact collagen and elastin structure, and neointimal growth was seen covering the basal quarter of the leaflets and commissures.


CONCLUSION
This new bioprosthesis might offer a particularly attractive alternative for the young patient population of the developing world. The simplicity of construction, low cost, and absence of any need for anticoagulation makes this prosthesis close to the ideal aortic valve substitute.
Prediction of a representative point for rail temperature measurement by considering longitudinal deformation
Monitoring rail temperature is very important for determining the safe running speed of trains and to prevent buckling. In general, the maximum variation of the internal rail temperature can be >7 ℃ depending on the point of measurement. However, there is as yet no sufficient information about how to predict the measurement point to represent the thermal deformation due to temperature distribution. In this study, the authors report a new point, called the representative measurement point, at which the rail temperature can be measured. This point considers the average deformation of the rail through structural analysis by adopting experimental and actual rail temperature data. The authors designed and installed a measurement system similar to an actual rail environment. Using the system, various data were acquired (internal/surface rail temperature and weather data) for 10 months. On the basis of these data, an analysis was done to calculate the average deformation point through thermal analysis. Finally, the representative measurement point was proposed as the position at which the average deformation point converges regardless of weather or seasons. The authors believe that the method described herein is advantageous in that it could be used in a high-accuracy temperature-monitoring system and for predicting thermal deformation and buckling.