THE NATURE OF MIGRAINE
It was, therefore, also with some hesitation that I accepted the invitation, humbly realizing that I can bring my audience nothing new, and when now, I nevertheless venture to try to speak about the nature of migraine seen from my point of view after a long life of work with migraineological problems, I do it to a very limited extent only on the basis of my own experience, but first and foremost because I base my opinion on the facts with which friends and colleagues have enriched our knowledge through their research, not only through numerous literary publications and lectures, but also and not least through the answers to personal inquiries which I have received with thanks in the course of time.
Migraine Occurring for the First Time in Pregnancy
SYNOPSIS
l-Phenylalanine dehydrogenase from Brevibacterium sp. for production of l-phenylalanine by reductive amination of phenylpyruvate
SummaryFor production of l-phenylalanine the reductive amination of phenylpyruvate, catalyzed by phenylalanine-dehydrogenase was examined. To reach high levels and a sufficient stability of the inducible intracellular enzyme, growth conditions of Brevibacterium sp. are optimized. For continuous production of l-phenylalanine in an enzyme membrane reactor, the kinetic parameters of the partially purified enzyme are determined.In continuous production a space time yield of 37.4 g l-Phe l-1 d-1 can be reached.By means of the measured kinetic parameters and simultaneous calculation of the mass balances of all reaction components the behaviour of the reactor can be simulated. For certain conditions the multi-enzyme-system shows multiple steady-states.