Destructive and Ultrasonic Investigations of Damage Development in Metallic Materials
Damage development due to creep under uniaxial tension at elevated temperatures is assessed using destructive and non-destructive methods in steels, commonly used in power plants or chemical industry, and in aluminium alloy used in aircrafts for responsible elements. The results obtained using two different destructive methods for assessments of damage development are critically discussed. In the first method the specimens of steel after different amounts of creep prestraining were stretched up to failure and variations of the selected tension parameters were taken into account for damage identification. In the second one, a damage degree was evaluated by studying variations of an initial yield locus position in the stress space and by determination of the yield loci dimensions. The ultrasonic investigations were selected as the non-destructive method for damage development evaluation.
The effect of predeformation on the creep and stress rupture of an oxide dispersion strengthened mechanical alloy
The effect of higher strain rate predeformation on creep behavior and stress rupture life of the oxide dispersion strengthened nickel-base alloy MA 754 was studied. Both the predeformation and creep testing were conducted at 760 °C. It was found that the minimum creep rate decreased as the amount of prestrain increased and was a factor of two lower at 1.2 pct prestrain. Predeformation also shortened the duration of primary creep. Transmission electron microscopy revealed dislocations being emitted from particle-matrix interfaces after prestraining and an increase in dislocation density with increasing prestrain. These observations are discussed with respect to the mechanical results.
Analysis of molecular interactions in solid dosage forms; challenge to molecular pharmaceutics.
The molecular states of active pharmaceutical ingredients (APIs) in pharmaceutical dosage forms strongly affect the properties and quality of a drug. Various important fundamental physicochemical studies were reviewed from the standpoint of molecular pharmaceutics. Mechanochemical effects were evaluated in mixtures of APIs and pharmaceutical additives. Amorphization, complex formation and nanoparticle formation are observed after grinding process depending on the combination of APIs and pharmaceutical additives. Sealed-heating method and mesoporous materials have been used to investigate drug molecular interactions in dosage forms. Molecular states have been investigated using powder X-ray diffraction, thermal analysis, IR, solid state fluorometry, and NMR.