Chloroperoxidase-catalyzed oxidation of N-methyl-4-chloroaniline
Chloroperoxidase catalyzed the H2O2 oxidative conversion of N-methyl-4-chloroaniline to 4-chloronitrosobenzene, 4-chloroaniline and a mixture of complex products.
Studies in peroxidase action—XX
Abstract The peroxidase catalysed oxidation of a mixture of p-toluidine and 4-chloroaniline gives rise to a large number of products. The major products, aminoanilinobenzoquinone dianils, are all derived from N-p-tolylbenzoquinone diimine. Perkin bases derived from 4,4′-dimethyldiphenylamine, azobenzenes and azophenines are also produced. The mechanism of the formation of the products is discussed.
Studies in peroxidase action—XIV
Abstract Previous work has shown that the peroxidation of p-toluidine gives a complex mixture of six products one of which is 4,4′-dimethyldiphenylamine. It has also been suggested2 that4-methyl-N2-p-toly-o-phenylenediamine is an intermediate compound in the oxidation. Experiments have now been carried out to demonstrate that both these compounds are possible reaction intermediates. It has also been established that the relative yields of the oxidation products depend upon the initial concentration of the p-toluidine. TLC and column chromatography have been extensively used in the separation and identification of the products.