Investigation of lactams
The recen t ly developed methods of synthesizing substi tuted 1H,2,3 ,4te t rahydroazepino[3,4-b] indoles [1-3] f rom cap ro l ac t am have opened broad pe r spec t ives for p repar ing condensed lndole de r iva t ives of biological in te res t [4]. In pa r t i cu la r , it became of in te res t to synthesize the indole analogs of such biological ly active compounds as Corazol ( a f t p e n t a m e t h y l e n e t e t r a z o l e ) [5], Omethy lcapro lac t im [6], and also a s e r i e s of 1,2and 10-subst i tu ted azepino[3,4b]indoles for pharmacologica l investigation.
Die Reaktion cyclischer Lactimäther mit Aminocarbonsäuren
Cyclische Lactimather reagieren mit aliphatischen und aromatischen, Aminocarbonsauren zunachst unter Bildung offenkettiger amidinartiger Verbindungen, die in der aliphatischen Reihe nur schwer zum Ring geschlossen werden konnen. Der Ringschlus vollzieht sich bei aromatischen und heterocyclischen o-Amino-carbonsauren sehr leicht. Die neue Synthese macht auch das Alkaloid Rutaecarpin (XV) leicht zuganglich.
The qualitative research interview
Background  Interviews are among the most familiar strategies for collecting qualitative data. The different qualitative interviewing strategies in common use emerged from diverse disciplinary perspectives resulting in a wide variation among interviewing approaches. Unlike the highly structured survey interviews and questionnaires used in epidemiology and most health services research, we examine less structured interview strategies in which the person interviewed is more a participant in meaning making than a conduit from which information is retrieved.