Phosphorescence of 8-azasteroids and related compounds.
We have investigated the electron absorption, fluorescence and phosphorescence spectra of 8-azasteroids and model compounds containing enaminodicarbonyl fragment. It has been shown that the investigated compounds have absorption and phosphorescence spectra similar in form and position. The results obtained permit the conclusion that the main deactivation channel of the excited singlet state is the intersystem crossing. It is suggested that the investigated 8-azasteroids of enaminodicarbonyl series under light irradiation undergo phototransformations presumably into derivatives with a gamma-pyridone fragment.
Development of a plasma 17α-hydroxyprogesterone time resolved-fluorescence immunoassay involving a new biotinylated tracer
A biotinylated 17alpha-hydroxyprogesterone probe (3) was prepared from 17alpha-hydroxyprogesterone-3-carboxymethyloxime and conjugate obtained by acylation of biotinylaminopropylammonium trifluroacetate. This new tracer was used in the development of a 17alpha-hydroxyprogesterone time-resolved fluoroimmunoassay using streptavidin-europium. The new method was compared to a long-standing radioimmunoassay method and found to be more sensitive and economical.
Towards a Formalisation of Justification and Justifiability
We introduce the logic QKD S which is a normal multi-modal logic over finitely many modalities that additionally supports bounded quantification of modalities. An important feature of this logic is that it allows to quantify over the information components of systems and, hence, can be used to derive justifications. We compare the proposed logic with Artemov’s justification logic and also report on a prototypical implementation of a satisfiability solver of this logic and show some examples.