Novel reaction of N,N'-bisarylmethanediamines with formaldehyde. Synthesis of some new 1,3,5-triaryl-1,3,5-hexahydrotriazines.
The acid-catalyzed cyclocondensation of N,N'-bisaryl (aryl = 2-pyrimidinyl, 2-pyrazinyl and 4-nitrophenyl) methanediamines 5a-c with aqueous formaldehyde in refluxing acetonitrile leads to the formation of the corresponding 1,3,5-triaryl-1,3,5-hexa-hydrotriazines 6a-c. The stoichiometric reactions of 2-aminopyrimidine and 2-amino-pyrazine with aqueous formaldehyde in acetonitrile under reflux conditions also afforded 6a and 6b, respectively. Treatment of 2-aminopyrimidine with aqueous formaldehyde in a 3:2 ratio yielded N,N',N"-tris(2-pyrimidinyl)dimethylenetriamine (7a) as a sole product, which upon subsequent reaction with formaldehyde also afforded 6a. The reaction of N,N'-biphenylmethanediamine with formaldehyde was also investigated.
Procédés de fabrication de poly(hexahydrotriazine)s par l'intermédiaire d'une polymérisation en suspension ou en émulsion
L'invention concerne un procede de fabrication d'un reseau covalent dynamique hemiaminal (HDCN) comprenant la reaction d'une diamine et d'un formaldehyde en presence d'un milieu de reaction comprenant un solvant polaire et un solvant non polaire a une temperature d'environ 15 o C a environ 100 o C pour former le HDCN. Une composition comprenant le HDCN produit peut etre moulee afin de former divers articles comprenant des poly(hexahydrotriazine)s.
Production of new antituberculosis drug and other medical preparations by electron beam treatment
Abstract Possibility of electron beam usage for immobilization of hydrazidum of an isonicotinic acid (HIA) on dextrane was studied to produce a drug for treatment of a tuberculosis. As a result of irradiation of dextrane the processes of oxidation and formation of polysaccharide occur due to carbonyl groups which are to link isoniasidum. The HIA immobilized on dextrane may be used as an effective medical preparation having prolonged action for action on endo and extracellular population of Micobacterium tuberculosis .