RELATIVE SUSCEPTIBILITY TO ARSENIC IN SUCCESSIVE INSTARS OF THE SILKWORM
The susceptibility of the silkworm to arsenic decreases during its larval development. Relative susceptibility may be expressed numerically as a ratio of areas under dosage-effect curves.
Drug effects as modified by aging.
Abstract Although chronologic age has been shown to be correlated with response to drugs in certain circumstances, such correlation is not inevitable nor is its nature predictable. At times increasing age seems to predispose to hyperreactivity, at times to hyporeactivity, and at times seems not to affect the magnitude of response in any significant way. The problems involved in establishing and assessing such correlations are discussed. It is suggested that the systematic collection of data bearing on this point may provide leads for important contributions to our understanding of the fate and action of drugs.
Experience of using rating scales for the assessment of vocational trainees in general practice.
For two years trainers in the northern half of the south western region have been asked to assess their trainees with a condensed version of the new Manchester rating scales for vocational training in general practice and to send copies to the regional adviser. The condensed version retains the 23 scales but does not include the subscales. Trainers' workshops and comments from individuals suggested that no radical improvements to the scales were required and that they were an adequate statement of what was required from trainees. The response rate of 89% for returning at least one assessment and 38% for returning all three suggested that use of this condensed version would be more feasible than using the full version of the scales. Analysis of 86 first assessments and 48 sets of three assessments showed a range of variation both in trainee ratings and use of individual scales that was consistent with expectations. A lack of significant rank correlations between the scales indicated that each of the scales measured a different characteristic of behaviour. We suggest that the most useful way to achieve systematic assessment of vocational trainees is by the use of the 23 main rating scales, with regional variations where appropriate.