Summary: New Techniques in Video Displays
The preceding papers are summarized, with their important points gathered together for convenient reference.
Inherent memory effects in ZnS:Mn thin film EL devices
Remarkable hysteresis were found to excist in a thin film multilayer EL device consisting of a ZnS:Mn active layer sandwiched between a pair of Y 2 )0 3 , insulating layers. Due to its particular construction, hysteresis was observed between the brightness vs. amplitude of the exciting alternating voltage, which is instrumental to realizing the memory function. Electrical Writing and Erasing are possible by the amplitude modulation of the sustaining voltage. The typical memory margin observed here is about 10 to 30 volts(rms) under operating voltage of 170 to 280 volts(rms) with frequency of 1 to 5 kHz. Gray scale display as well as Optical Writing are possible.
Modulating dopamine receptors subtype selectivity by thiophene and benzothiophene based derivatives
In this work we tried to develop new dopaminergic ligands with novel affinity and selectivity profile towards the five different dopamine receptor subtypes; namely D1, D2, D3, D4, and D5 receptors to come up with new medical agents but with fewer side effects relative to those present in the medicinal market such as Haloperidol that is considered to be among the very famous typical antipsychotic agents characterized with Extrapyramidal symptoms adverse effects and Clozapine that represents the atypical antipsychotic agents that suffers agranulocytosis adverse effects. Among the fifty five synthesized ligands, compounds 3, 44a, and 45a were shown to have unique subtype receptor selectivity, thus could be promising atypical antipsychotic agents. Compound 3 was the first azecine derivative to show antagonistic action on both D2 and D5 receptor subtypes, (Ki (D2): 1.5 nM; Ki (D5): 1.9 nM). Compound 44a showed to be more than 200 times more selective to D2 receptors rather than D4 (Ki (D2): 138 nM; Ki (D4):0.62 nM). Compound 45a has shown to be more than 100 times more selective to D3 rather than D2 receptor subtypes and more than 900 times more selective to D4 rather than D2 receptor subtypes (Ki (D2): 28.5 nM; Ki (D3): 0.26 nM; Ki (D4): 0.03 nM).