Metabolites of furazolidone in urine of chickens.
Colostomized chickens were medicated with single oral doses of the antibacterial furazolidone. An average of 7.5 ± 3.0% of the dose was excreted in the urine within 12 hr. as compounds measured by a procedure in which they react to form 5-nitrofurfural phenylhydrazone. Chromatographic analysis delected four metabolites containing a furan ring. Only one metabolite reacted to form 5-nitrofurfural phenylhydrazone. Elimination of the metabolites with a furan ring was complete in 12 hr. Only traces of furazolidone were detected by the chromatographic procedure.
Method specific for determination of furazolidone in urine: evidence for drug-related metabolites.
Furazolidone, N -(5-nitro-2-furfurylidene)-3-amino-2-oxazolidinone, is a chemotherapeutic drug used orally for the treatment of bacterial enteritis. A new, more specific analytical method for the determination of furazolidone in urine is described. Utilizing this procedure, furazolidone was not detected in urine samples collected from dogs and humans following oral administration of the drug. Evidence is provided for the presence of drug-related metabolites.
First diamino Daphniphyllum alkaloid, daphnipaxinin, with an unprecedented heterohexacyclic skeleton from Daphniphyllum paxianum.
[structure: see text] The first diamino Daphniphyllum alkaloid, daphnipaxinin (1), with an unprecedented hexacyclic fused skeleton, along with a known alkaloid, daphnicyclidin A (2), was isolated from the stem of Daphniphyllum paxianum Rosenth. The structure and absolute stereochemistry of 1 were established by spectral methods, especially two-dimensional NMR techniques and CD analysis.