Synthesis and Characterisation of Macrocyclic Diamino Chiral Crown Ethers
A benign and efficient synthesis of chiral macrocyclic ‘aza-crown’ ethers of varying ring size is reported. The synthesis involves a Schiff base condensation of ether linked dialdehydes of varying chain length and (1R,2R)-(–)-1,2-diaminocyclohexane under mild conditions to yield the macrocycles, which are subsequently reduced to yield the diamino analogues.
Benign approaches for the synthesis of bis-imine Schiff bases
Pure bis-imine Schiff bases are readily accessible in high yield, typically >95%, when aliphatic diamine/aldehyde condensation reactions are carried out under solvent-free conditions or in poly(propyleneglycol) (PPG) as a recyclable reaction medium, with negligible waste.
Subject index
Adoptive immunotherapy A1, A63, A63, A64, A64, A65, A66, A68, A69, A69, A70, A70, A71, A71, A72, A72, A73, A73, A74, A75, A76, A78, A79, A79, A7, A80, A80, A81, A81, A82, A84, A85, A86, A86, A88, A88, A89, A90, A90, A91, A92, A93, A93, A94, A95, A95, A96, A96, A97, A97, A98, A98, A99, A99, A102, A103, A104, A104, A166, A167, A169, A170, A174, A177, A179, A181, A182, A199, A204, A205, A21, A215, A220, A231, A231, A243, A251, A254, A25, A276, A287, A304, A307, A310, A315, A316, A316, A329, A331, A333, A357, A358, A369, A405, A441, A442, A458, A458, A459, A459, A461, A461, A463, A468, A468, A479, A492, A497, A497, A56, A58, A58, A59, A60, A60, A61, 1, 100, 101, 102, 103, 104, 106, 109, 111, 112, 113, 114, 115, 116, 117, 119, 120, 122, 123, 124, 125, 127, 128, 129, 13, 130, 131, 133, 134, 136, 139, 140, 141, 142, 146, 147, 148, 149, 150, 152, 153, 154, 155, 156, 157, 158, 159, 160, 161, 163, 164, 165, 166, 167, 169, 173, 174, 175, 272, 273, 278, 280, 285, 290, 293, 297, 298, 324, 333, 335, 35, 353, 360, 379, 380, 400, 414, 418, 42, 454, 470, 493, 500, 504, 513, 515, 516, 542, 545, 549, 598, 599, 614, 675, 737, 739, 764, 765, 766, 767, 770, 771, 772, 780, 781, 801, 822, 830, 831, 89, 91, 92, 94, 95, 96, 98 Angiogenesis A108, A155, A171, A200, A201, A214, A228, A265, A305, A349, A350, A359, A410, A47, A48, A480, A483, A519, A5, 181, 257, 281, 327, 328, 351, 374, 435, 495, 583, 584, 602, 683, 76, 78, 802, 808, 873, 9 Antibody A7, A73, A81, A86, A91, A8, A99, A9, A104, A108, A108, A109, A109, A111, A115, A119, A126, A128, A130, A135, A138, A141, A144, A151, A153, A159, A160, A163, A164, A164, A171, A172, A175, A176, A2, A187, A193, A193, A195, A195, A198, A199, A20, A209, A212, A225, A229, A230, A23, A233, A233, A235, A239, A239, A240, A242, A244, A244, A245, A245, A246, A247, A247, A24, A250, A256, A260, A261, A266, A267, A268, A269, A273, A275, A286, A288, A292, A293, A296, A299, A300, A307, A3, A308, A31, A318, A324, A35, A334, A334, A336, A338, A339, A342, A343, A344, A344, A346, A346, A351, A351, A353, A356, A360, A361, A363, A368, A369, A370, A371, A372, A372, A373, A374, A376, A377, A378, A378, A379, A379, A380, A380, A388, A391, A399, A399, A41, A402, A410, A410, A411, A412, A414, A417, A418, A419, A419, A420, A422, A422, A423, A426, A427, A428, A428, A430, A431, A432, A434, A434, A435, A446, A454, A455, A459, A463, A465, A468, A468, A469, A474, A481, A483, A50, A486, A487, A491, A502, A502, A504, A507, A507, A508, A510, A511, A512, A512, A516, 12, 122, 133, 141, 151, 16, 167, 17, 174, 181, 182, 184, 185, 188, 195, 203, 210, 215, 218, 227, 231, 237, 243, 250, 253, 261, 262, 265, 267, 268, 281, 282, 287, 288, 3, 305, 313, 315, 317, 318, 323, 325, 34, 342, 348, 369, 377, 378, 38, 384, 385, 387, 393, 394, 395, 399, 401, 402, 403, 404, 405, 406, 407, 41, 412, 421, 428, 429, 438, 439, 442, 443, 450, 453, 469, 472, 476, 478, 480, 483, 486, 499, 5, 501, 51, 519, 531, 55, 550, 552, 557, 561, 562, 569, 571, 572, 573, 576, 578, 586, 587, 590, 594, 603, 605, 607, 612, 615, 616, 617, 618, 619, 621, 622, 626, 629, 630, 631, 632, 633, 634, 635, 647, 653, 665, 666, 67, 670, 683, 684, 686, 687, 690, 693, 696, 697, 698, 699, 702, 703, 704, 711, 713, 714, 715, 718, 721, 722, 725, 726, 727, 745, 757, 760, 766, 772, 776, 780, 781, 785, 793, 804, 808, 81, 812, 814, 820, 842, 843, 846, 851, 852, 853, 856, 858, 860, 861, 869 Antigen presenting cells A67, A79, A80, A92, A95, A96, A99, A99, A101, A102, A102, A108, A108, A111, A129, A139, A160, A166, A177, A178, A183, A191, A191, A213, A220, A221, A245, A254, A256, A262, A266, A275, A314, A322, A327, A328, A35, A335, A345, A359, A359, A360, A361, A364, A366, A368, A369, A371, A372, A403, A409, A411, A411, A418, A422, A433, A449, A48, A468, A471, A472, A4, A50, A495, A502, A506, A513, A514, A515, 108, 128, 130, 153, 157, 160, 166, 167, 168, 169, 170, 181, 182, 188, 217, 235, 263, 271, 290, 291, 299, 310, 311, 349, 360, 362, 404, 418, 421, 431, 438, 453, 510, 526, 538, 540, 55, 553, 575, 601, 602, 603, 605, 610, 611, 612, 615, 617, 618, 672, 682, 685, 686, 695, 703, 724, 748, 78, 780, 787, 790, 8, 81, 828, 842, 849, 862, 864, 868 Autoimmunity A8, A116, A15, A180, A181, A22, A380, A387, A394, A395, A402, A408, A502, A510, 16, 197, 27, 295, 296, 37, 637, 645, 657, 658, 671, 680, 843, 856