Medicinal Properties of Tinospora Cordifolia (Guduchi)
Tinospora cordifolia is one of the most important medicinal plant commonly known as Giloy belonging to menispermaceae family is a deciduous climbing shrub described known for its immense application in the treatment of various diseases such as jaundice, fever, diabetes, and skin diseases etc.The chemical constituents of this shrub belong to different classes such as alkaloid, lactones, steroids, phenolics, aliphatic compound, glycosides and polyscharide compounds having medical importance.
Tinocordifolin, a sesquiterpene from Tinospora cordifolia
A new daucane-type sesquiterpene, tinocordifolin, has been isolated from the stem of Tinospora cordifolia and its structure established by detailed spectroscopic studies.
Restoration of Thymic Homeostasis in a Tumor-Bearing Host by in Vivo Administration of Medicinal Herb Tinospora Cordifolia
In vivo administration of alcoholic extract of medicinal plant Tinospora cordifolia (TC) to mice bearing a spontaneous T cell lymphoma designated as Dalton’s lymphoma prevented tumor growth-dependent regression of thymus. TC was found to augment proliferation of thymocytes with a concomitant decrease in thymocyte apoptosis. It also resulted in a decrease in the number of Hassal’s corpuscles. Restoration of thymus homeostasis was caused by TC-dependent augmentation in production of thymocyte growth promoting cytokines Interleukin-2 and Interferon-gamma from thymocytes. TC was found to downregulate thymocyte apoptosis by modulation of Caspase pathway. TC administration retarded tumor growth and prolonged survival of tumor-bearing mice. The possible mechanisms are discussed.