Operating experience of the United States National High Magnetic Field Laboratory 60 T Long Pulse Magnet
The 60 T Long-Pulse (60 T LP) magnet system has provided controlled power magnetic field pulses to experimentalists since August 3, 1998. This magnet system is installed as part of the user facility research equipment at the National High Magnetic Laboratory (NHMFL) Pulsed Field Facility at Los Alamos National Laboratory. The 60 T LP magnet is the first of its kind in the United States and produces the highest field in its class, routinely providing a 60 T pulsed field of 100 ms flat-top duration in a 32 mm diameter bore. In addition, numerous other controlled pulse shapes at 60 T and lower fields have been provided. Since the start of commissioning on September 17, 1997 the magnet has been pulsed in excess of 800 times at various field levels. More than 600 magnet pulses have been provided to experiments and almost 400 of these were at 60 T. Operating statistics including coil system and inductance and resistance histories are presented. Operating and maintenance experience and issues are discussed as well as realizable improvements and upgrades to the magnet.
Design and Analysis of a Combined Power Supply for High-Field Quasi-Continuous Magnets
The high-field quasi-continuous magnets (QCM) are of great interest for scientific experiments that require long pulse duration and in particular a field pulse with a flat-top. For the QCM, the power supply is a real challenge. At the Wuhan National High Magnetic Field Center (WHMFC), it is planned to realize a 45 T/500 ms flat-top field by the series combination of a 0.6 kV/35 kA battery bank and a 12-pulse rectifier that is powered by a 100 MVA/100 MJ flywheel pulse generator (FPG). In order to reduce the dc current ripple, a dc passive filter is connected in parallel with the rectifier. The simulation of the pulse shape with respect to the voltage profile supplied by the power supply takes the resistance of the magnet into account; this increases with temperature as a function of coil current. The configuration and the associated control strategy are presented in this paper. A simulation model of the combined power supply system is developed and compared with the model of a single rectifier supply system. Results are provided to validate the proposed method.
Nuclear sphingolipid metabolism.
Nuclear lipid metabolism is implicated in various processes, including transcription, splicing, and DNA repair. Sphingolipids play roles in numerous cellular functions, and an emerging body of literature has identified roles for these lipid mediators in distinct nuclear processes. Different sphingolipid species are localized in various subnuclear domains, including chromatin, the nuclear matrix, and the nuclear envelope, where sphingolipids exert specific regulatory and structural functions. Sphingomyelin, the most abundant nuclear sphingolipid, plays both structural and regulatory roles in chromatin assembly and dynamics in addition to being an integral component of the nuclear matrix. Sphingosine-1-phosphate modulates histone acetylation, sphingosine is a ligand for steroidogenic factor 1, and nuclear accumulation of ceramide has been implicated in apoptosis. Finally, nuclear membrane-associated ganglioside GM1 plays a pivotal role in Ca(2+) homeostasis. This review highlights research on the factors that control nuclear sphingolipid metabolism and summarizes the roles of these lipids in various nuclear processes.