A radioimmunoassay combined with solid-phase extraction for the determination (pg ml-1) of AR-C15849XX) in human plasma.
A radioimmunoassay has been developed for the determination of AR-C15849KF, a CCK-8 analogue, in human plasma. The method incorporates solid-phase sample extraction, is suitable for the determination of the analyte at pg ml-1 concentrations and is based on a method developed and validated for dog plasma. The solid-phase extraction, using ion-exchange aminopropyl and octadecyl sorbents sequentially, was retained for this procedure to remove matrix interferences in the plasma and to enhance method sensitivity. The calibration range is 10-500 pg ml-1, using a 1 ml sample of undiluted human plasma. The method has been successfully used to generate early human pharmacokinetic data during a programme of exploratory development.
A radioimmunoassay combined with solid-phase extraction for the determination of a novel anti-obesity agent, ARL 15849XX, in dog plasma.
A radioimmunoassay has been developed for the determination of ARL 15849XX, a cholecystokinin-8 (CCK-8) analogue, in dog plasma. The method incorporates solid-phase sample extraction and is suitable for the determination of the analyte at picogram per millilitre concentrations. The antiserum was raised in Suffolk-cross sheep following primary and booster immunisations with an immunogen prepared by conjugating ARL 16935XX, an analogue of ARL 15849KF, to bovine serum albumin. The radioligand was prepared by the no-carrier-added 125I iodination of a non-sulphated derivative, ARL 15745XX. The solid-phase extraction procedure, carried out using ion-exchange aminopropyl and octadecyl sorbents sequentially, was introduced to remove matrix interferences in the plasma and to enhance the method sensitivity. The calibration range is 20-1000 pg ml-1, using a 1 ml sample of undiluted dog plasma.
Beyond zero tolerance : discrimination in military culture
Chapter 1 Introduction: Rethinking Military Culture Part 2 Constructing Military Culture Chapter 3 Discrimination and Military Cohesion: An Organizational Perspective Chapter 4 Military Folk Culture Chapter 5 Dressed to Kill? The Paradox of Women in Military Uniforms Chapter 6 A Tangled Webb the Navy Can't Afford Chapter 7 Women at the U.S. Army War College Part 8 The Military, Society, and Policy Chapter 9 Reflections of Society: The Intersection of Race and Gender in the U.S. Army in World War II Chapter 10 Intersectionality: A Necessary Consideration for Women of Color in the Military? Chapter 11 In War and Peace: Incidence and Implications of Rape by Military Personnel Chapter 12 Persistence of Sexual Harassment: The Impact of Military Culture on Policy Implementation Chapter 13 A Culture of Silence: Consequences of Don't Ask, Don't Tell, Don't Pursue Chapter 14 Gender and Sexual Orientation Diversity in Modern Military Forces: Cross-National Patterns Chapter 15 Military Culture and Military Families