Chemical Constituents Of Mitrella Kentii ( Annonaceae ) Ainnul Hamidah
Abstract: Mitrella kentii which belongs to the Annonaceae family is a tree-climbing liana found in the Malaysian Peninsula, Islands of Sumatra, Borneo, and New Guinea. This species was studied in 1972 for their alkaloids, 1997 and 2012 for their non-alkaloid constituents. In this study, chalcones, Desmosdumotin C (1) and their tautomer, 2-cinnamoyl3-hydroxy-5-methoxy-4,6,6-trimethylcyclohexa-2,4-dienone (2), flavanone, 7-hydroxy-5,6-dimethoxy-2-phenylchroman4-one (3), oxoaporphine alkaloids, Liriodenine (4) and Atherospermidine (5) and also terpenoid, -Sitostenone (6) have been isolated from this species. All these compounds were isolated for the first time from Mitrella kentii except Liriodenine (4). The isolated compounds were elucidated using spectroscopic techniques such as UV, IR,1D and 2D NMR and mass spectroscopy and by comparison their spectral data with those previously reported in the literatures. Desmosdumotin C (1) showed the anti-ulcer activity.
Desmosdumotin C, a novel cytotoxic principle from Desmos dumosus
Abstract The structure of desmosdumotin C ( 1 ), a novel compound isolated from the roots of Desmos dumosus, has been established from spectral data and X-ray crystallographic analysis. Significant and selective in vitro cytotoxicity of 1 was found against bone (HOS), breast (MCF), and ovarian (IA9) cancer cell lines.
Identification of Dihydroxy Aromatic Compounds in a Low-Temperature Pyrolysis Coal Tar by Gas Chromatography−Mass Spectrometry (GC−MS) and Fourier Transform Ion Cyclotron Resonance Mass Spectrometry (FT-ICR MS)
Dihydroxy aromatics in coal tar undergo rapid coupling reactions with each other and with some coal-derived species during coal pyrolysis and liquefaction. However, only limited information on the structure of dihydroxy aromatics is known. In this study, Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS) and gas chromatography−mass spectrometry (GC−MS) were used to characterize the dihydroxy aromatics in a low-temperature pyrolyzed coal tar and its distillate and residue fractions. Negative-ion electrospray ionization (ESI) FT-ICR MS spectra of coal-tar-derived samples had low molecular masses and narrow mass ranges. Negative-ion ESI is extremely selective for the dihydroxy aromatics present in coal tar. The O2 class species had the highest ion intensity among the species in the negative-ion FT-ICR mass spectrum for each sample. Dihydroxy compounds with an aromatic core structure of benzene, indan, biphenyl (and/or acenaphthene), and naphthalene were identified in the distillate fract...