Detonation loading of tubes in the modified shear wave speed regime
We performed experiments and numerical simulations on a thin-wall aluminum tube with internal gaseous detonation loading in the modified shear wave speed regime. Strain gauges were used to determine the time-dependent hoop strain on the surface of the tube. The experimental results were compared with analytical models and numerical simulations with explicit finite element computation treating the detonation as a traveling load. Hoop strain amplification factors (defined as the ratio of the dynamic strain to the equivalent static strain) close to two were obtained both in the present experiments and simulations. No resonance phenomena in the hoop strain were found in either experiments or simulations. Computations reveal the existence of a resonance in the shear strain.
The Structural Response of Cylindrical Shells to Internal Shock Loading
The internal shock loading of cylindrical shells can be represented as a step load advancing at constant speed. Several analytical models are available to calculate the structural response of shells to this type of loading. These models show that the speed of the shock wave is an important parameter. In fact, for a linear model of a shell of infinite length, the amplitude of the radial deflection becomes unbounded when the speed of the shock wave is equal to a critical velocity. It is evident that simple (static) design formulas are no longer accurate in this case. The present paper deals with a numerical and experimental study on the structural response of a thin aluminum cylindrical shell to shock loading. Transient finite element calculations were carried out for a range of shock speeds. The results were compared to experimental results obtained with the GALCIT 6-in. shock tube facility. Both the experimental and the numerical results show an increase in amplitude near the critical velocity, as predicted by simple steady-state models for shells of infinite length. However, the finite length of the shell results in some transient phenomena. These phenomena are related to the reflection of structural waves and the development of the deflection profile when the shock wave enters the shell.
Modulation of neuronal serotonin uptake by a putative endogenous ligand of imipramine recognition sites.
Imipramine inhibits the serotonin uptake by binding with high affinity to regulatory sites of this uptake located on axons that release serotonin. The number of imipramine recognition sites located on crude synaptic membrane preparations is reduced by two daily injections of imipramine or desmethylimipramine for 3 weeks. When the binding sites for [3H]imipramine are down-regulated the Vmax of the neuronal uptake of serotonin is increased. Moreover, in minces prepared from the brain hippocampus of rats receiving imipramine in a dose regimen that reduces the number of [3H]imipramine recognition sites, the efficiency of imipramine as a blocker of the serotonin uptake is diminished. Hence the high-affinity binding sites for [3H]imipramine may have a physiological role in modulation of serotonin reuptake. Probably this is mediated by an endogenous effector of these regulatory sites. A nonpeptidic constituent of rat brain capable of displacing [3H]imipramine from its high-affinity binding site and of inhibiting the serotonin uptake in a dose-related manner has been extracted and its partial purification is described.