Structure of stenanzidinine
On the basis of the results of a study of the chemical and physical characteristics of the alkaloid itself and of the products of its transformation, the most probable structure and partial configuration of stenanzidinine have been established as 3β, 6α-dihydroxycevanine.
Configuration and reactivity of ten-membered 5,10-seco-compounds obtained by fragmentation of 5-hydroxy-steroids
Abstract Assignment of configuration to the 1,10-double bond in the cis-trans isomeric 3β-acetoxy-5,10-seco-1,10-cholesten-5-ones has been achieved by means of NMR spectrometry. Some reactions of these new compounds have been studied and, as expected from conformational analysis, it was found that only the trans-isomer readily undergoes transannular cyclizations.
Opening of steroid ring a by means of lead tetraacetate
Abstract The lead tetraacetate oxidation of cholestan-1β-ol and cholestan-1α-ol in benzene solution did not afford cyclic ethers but resulted, in major part, in the opening of ring A with formation of 1,10-seco-aldehydes. In addition, cholestane, cholest-1-ene and cholestan-1-one were also obtained.