Panoramic view of common fusion genes in a large cohort of Chinese de novo acute myeloid leukemia patients
Abstract Fusion genes are major molecular biological abnormalities in hematological malignancies. This study aimed to depict the common recurrent gene fusion landscape in acute myeloid leukemia (AML) 3135 de novo AML cases were enrolled and 36 recurrent fusion genes were assessed using multiplex nested RT PCR. Twenty three distinct fusion genes were detected in 1292 (41.21% cases. The incidence of fusion genes was higher in pediatric AML than in adult cases. The pediatric patients had higher incidences of RUNX1 RUNX1T1, KMT2A MLLT3, KMT2A MLLT10, KMT2A MLLT11, KMT2A MLLT6, and FUS ERG, whereas KMT2A PTD was more common in adult patients. The occurrence of molecular abnormalities involving the KMT2A gene and CBFB MYH11 was lower in Chinese pediatric AML compared to Western reports. The incidence of RUNX1 RUNX1T1 was higher in both pediatric and adult patients in our study than in Western countries. This study provides a genetic landscape of common fusion genes in Chinese AML and confirms different incidences between age groups and races.
Leukemia lymphoma