Blockade of Treg Cell Differentiation and Function by the Interleukin 21 Mechanistic Target of Rapamycin Axis Via Suppression of Autophagy in Patients With Systemic Lupus Erythematosus
The mechanistic target of rapamycin (mTOR) has become a therapeutic target in systemic lupus erythematosus (SLE) In T cells, mTOR plays a central role in lineage specification, including development of regulatory cells (Treg cells) This study sought to investigate whether mTOR is activated within Treg cells and whether this contributes to the depletion and dysfunction of Treg cells in patients with SLE.
Arthritis rheumatology