One pot synthesis of 2 amino 3,4 dicyanopyridines from ketoximes and tetracyanoethylene via Cu(I) catalyzed cyclization
Abstract A novel approach to 2 amino 3,4 dicyanopyridines has been discovered from Cu(I) catalyzed cyclizations of simple and easily available ketoximes and tetracyanoethylene (TCNE) The complexed radical mechanism involves cleavage of several O H/N O/C H bonds, and new C C/C N bonds formation. A wide variety of substrates with different functional groups could be smoothly converted into the corresponding products in moderate yields.
Tetrahedron