Probiotics and Obesity
from the group of Gordon et al. [1, 2] who characterized the composition of the fecal microbiota by extensive 16S rRNA gene sequence analysis, the authors of the 2 recent human studies [4, 5] applied 16S rRNA targeted oligonucleotide probes for the quantification of major bacterial groups. However, the probes used in these trials do not detect members of the Erysipelotrichaceae, a bacterial family within the Firmicutes, which was shown in mice to be largely responsible for the increase in Firmicutes observed in response to a high fat diet [6]
Annals of Nutrition and Metabolism