Synthesis of Fe3O4@Gd2O3:Tb3+@SiOx multifunctional nanoparticles and their luminescent, magnetic and hyperthermia properties.
Multifunctional Fe3O4@Gd2O3:Tb3+@SiOx nanoparticles were successfully synthesized by co precipitation and polyol methods. The synthesized nanoparticles were composed of cubic phase as core of Fe3O4 and Gd2O3:Tb3+ and the shell of amorphous SiOx. The composites exhibited spherical shape with a diameter of 10 15 nm and highly uniform dispersion. They showed not only excellent fluorescence under the excitation at wavelength of 278 nm, but also strong magnetic responsiveness (MS 24.040 emu/g) The results of magnetic resonance (MR) imaging in vitro (r1 6.00 mm 1s 1, r2 63.95 mm 1s 1) showed that the samples could be used as T1 positive and T2 negative contrast agents. In addition, it was found that Fe3O4@Gd2O3:Tb3+@SiOx attains hyperthermia temperature (43 degC) in 90 s under the alternating current (AC) magnetic field, and their specific absorption rate (SAR) (229.9 w/g) was higher than that of Fe3O4 (183.92 w/g) Hence, the multifunctional nanoparticle could be used for the diagnosis and therapy of cancer.
Nanotechnology