The Concept of AI Based Algorithm: Analysis of CEUS Images and HSPs for Identification of Early Parenchymal Changes in Severe Acute Pancreatitis
(1) Background: Identifying early pancreas parenchymal changes remains a challenging radiologic diagnostic task. In this study, we hypothesized that applying artificial intelligence (AI) to contrast enhanced ultrasound (CEUS) along with measurement of Heat Shock Protein (HSP)70 levels could improve detection of early pancreatic necrosis in acute pancreatitis. (2) Methods: Acute pancreatitis (n 146) and ageand sex matched healthy controls (n 50) were enrolled in the study. The severity of acute pancreatitis was determined according to the revised Atlanta classification. The selected severe acute pancreatitis (AP) patient and an age/sex matched healthy control were analysed for the algorithm initiation. Peripheral blood samples from the pancreatitis patient were collected on admission and HSP 70 levels were measured using ELISA. A CEUS device acquired multiple mechanical index contrast specific mode images. Manual contour selection of the two dimensional (2D) spatial region of interest (ROI) followed by calculations of the set of quantitative parameters. Image processing calculations and extraction of quantitative parameters from the CEUS diagnostic images were performed using algorithms implemented in the MATLAB software. (3) Results: Serum HSP 70 levels were 100.246 ng/ml (mean 76.4 ng/ml) at the time of the acute pancreatitis diagnosis. The CEUS Peek value was higher (155.5) and the mean transit time was longer (40.1 s) for healthy pancreas than in parenchyma affected by necrosis (46.5 and 34.6 s, respectively) (4) Conclusions: The extracted quantitative parameters and HSP 70 biochem*Corresponding authors. 306 A. Kielaite Gulla et al. ical changes are suitable to be used further for AI based classification of pancreas pathology cases and automatic estimation of pancreatic necrosis in AP.
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