Improvement of bisphenol A quantitation from urine by LCMS
AbstractBisphenol A (BPA) is a synthetic chemical extensively used in many consumer products. It mimics estrogen activities and is related to developmental disorders and metabolic diseases. The current challenge of BPA detection is their low circulating levels at 0.1~10 ng/mL which is close to the detection limit of most of current analytical methods. In this report, we developed a simple, sensitive, and accurate liquid chromatography mass spectrometry (LCMS) method after 1 methylimidazole 2 sulfonyl chloride derivatization. The method significantly improves sensitivity 5~9 fold over dansyl derivatization and approximately 100 fold without derivatization. Graphical abstractBPA: Bisphenol A; ISCl: 1 methylimidazole 2 sulfonyl chloride; NaHCO3: sodium bicarbonate
Analytical and Bioanalytical Chemistry