Assembly of Functionalized 4 Alkynylisoxazoles by Palladium Catalyzed Three Component Cascade Cyclization/Alkynylation.
A novel N heterocyclic carbene (NHC) palladium catalyzed three component cascade cyclization/alkynylation for the synthesis of structurally diverse 4 alkynylisoxazoles was efficiently developed in ionic liquids. The operational simplicity, without additives, no additional ligands, and 0.5 mol catalyst loading under air are some of the attractive features of this present protocol.
Chemistry, an Asian journal