Progress in the Pathogenesis of Liver Injury in Sepsis
Liver injury plays an important role in the development of sepsis,and improving liver function helps to improve the prognosis of patients. Therefore,the pathogenesis of liver injury in sepsis research has important clinical value. The current study suggests that the pathogenesis of septic liver is as follows: sepsis caused hepatic microcirculation and hepatic blood flow changes lead to hypoxic ischemic liver cells,and if combined energy metabolism of liver cells exists,liver injury is then caused. Endotoxin directly damages Kupffer cells,while the endotoxin can cause inflammatory cytokines changes which aggravates the liver injury. The massive release of oxygen free radicals and lipid peroxidation product malondialdehyde in sepsis cause damage to the integrity of mitochondrial membrane and cell membranes,causing liver injury. The role of platelet activating factor,hepatocyte apoptosis,and some other processes together cause the liver injury in sepsis,and here is to make a review of the above mentioned mechanisms of septic liver injury.