Chrysin Alleviates Monocrotaline induced Pulmonary Hypertension (MCTPH) in Rats via Regulation of Intracellular Calcium Homeostasis in pulmonary arterial smooth muscle cells (PASMCs)
Chrysin (CH) is the main ingredient of many medicinal plants. Our previous study showed that CH could suppress hypoxia induced PASMC proliferation and alleviate chronic hypoxia induced pulmonary hypertension (CHPH) by targeting SOCE [Ca]i pathway. In this study, we investigated the effect of CH on MCT induced pulmonary hypertension (MCTPH) and the mechanism behnd it. Results show that, in MCTPH model rats, 1) CH significantly reduced the enhancement of right ventricular pressure, right ventricular hypertrophy, and pulmonary vascular remodeling; 2) CH markedly suppressed the promotion of SOCE and [Ca]i in PASMCs and 3) CH obviously inhibited the MCT upregulated PCNA, TRPC1, TRPC4 and TRPC6 expression in distal pulmonary arteries. These results demonstrate that CH likely alleviates MCTPH by targeting TRPC1,4,6 SOCE [Ca]i pathway.
Journal of cardiovascular pharmacology