COVID 19: its impact on dental schools in Italy, clinical problems in endodontic therapy and general considerations
Dear Editor COVID 19 is a novel disease caused by a member of the coronavirus family that originated in Wuhan, Hubei, China in December 2019. Over the last few months, the infection has spread to several countries worldwide. Coronaviruses are described by the World Health Organisation (WHO) as a large family of viruses, which may cause illness in animals or humans (https:/www.who.int/news room/q a detail/ q a coronaviruses) Although COVID 19 infections in humans most often present with mild symptoms, in a variable percentage of cases, it can cause an acute respiratory syndrome, which has led to patient fatalities (Phan 2020, Lu et al. 2020) COVID 19 appears to be a particular risk for patient with pre existing medical conditions (such as high blood pressure, heart disease, lung disease, cancer or diabetes; https:/www.who.int/news room/q a detail/q a coron aviruses) Recently, a letter has been published, detailing the potential impact of COVID 19 in Dentistry (SabinoSilva et al. 2020) whilst other articles have set out the routes of transmission, implications and controls required in dental practice (Peng et al. 2020) In addition, various world, national and dental organizations have issued guidance, for example American Dental Association (http:/success.ada.org/en/practice mana gement/patients//media/ 32D2D1F13B3D4D919E67CFBC00AF71B0.pdf) British Dental Association (https:/bda.org/news centre/ latest news articles/Pages/Wuhan novel coronavirusadvice for dentists.aspx) and the WHO (https:/www. who.int/news room/q a detail/q a coronaviruses) At the present time, the principle challenge is that the population has no innate protection against COVID 19 and a vaccine has not been developed. It is also of note that no specific antiviral therapy has currently proven to be effective against SARS CoV 2 (the virus causing the disease COVID 19) This combination of no vaccine as well as no effective therapeutic countermeasure is potentially leading to an unknown but possibly challenging scenario with millions of people becoming infected globally. This would inevitably have a major impact on daily life, with the potential to drive even the healthcare systems in developed countries to the brink of collapse. Although the exact transmission routes are yet to be determined with certainty, as with influenza and many other viruses affecting the upper and lower respiratory airways, aerosol transmission between humans has been confirmed. The mean incubation period is estimated to be around 5 days (but probably ranges from 1 to 19 days) which allows travel to spread the disease globally (https:/www.who.int/ne ws room/q a detail/q a coronaviruses) Interestingly, only a few paediatric cases have been reported, whilst in contrast, adult and older patients are frequently involved with some requiring hospitalization and even intubation within intensive care units (Rothan Byrareddy 2020) The clinical and virological evidence to date is not sufficiently robust to exclude the possibility that virus transmission can occur during the incubation period from infected but asymptomatic patients. Symptoms of COVID 19 are very similar to those of human influenza and include a fever, cough, rhinitis, myalgia, conjunctivitis and fatigue. From a European perspective, at least two separate clusters of infection have been identified in Northern Italy. The entire area of Italy is now a 'red zone' with multiple limitations imposed on education, work and transport. However, considering the rapid spread of the virus, additional restrictions on the movement of the population are being considered in an attempt to reduce the number of patients. All the Italian Schools and Universities suspended teaching activity on 24th February, 2020. The rationale for this decision was to minimize the transmission of the virus between persons of different areas in the hope of reducing the spread of the infection. Considering that SARS CoV 2 has been identified in the saliva of infected patients and that screening to determine the presence of the virus in Italy is carried out by sampling nasopharyngeal secretions, all Medical Doctors, Nurses and Dentists exposed to potential contact with this biological material are, at least in theory, exposed to an unknown risk of acquiring the SARS CoV 23 agent. Notably, the spread of the
International endodontic journal