FORMULATION AND EVALUATION OF BUCCO ADHESIVE TABLETS OF INSULIN USING LOCUST BEAN GUM B. Arun Prasanth* R. Sankaranand, V. Venugopal, P. Sathvika, R. Pranitha, M. Ashritha, V. Swathi and K. Jyothirmai
The present study is to develop a buccoadhesive drug delivery system of Insulin using natural polymer locust bean gum in order to overcome the poor permeability and ineffectiveness when administered orally. Insulin is a polypeptide anti diabetic agent usually administered through injections. The use of these injections throughout life of a patient presents various problems, such as physical and psychic pain, hypertrophy or atrophy of the subcutaneous fat at an injection site. Also when taken orally results in short biological half life and ineffectivness due to enzymatic degradation and poor permeability. As insulin is a peptide drug, its delivery via the buccal oral cavity has several therapeutic advantages. Locust bean gum is a mucoadhesive polymer. It is useful as a stabilizer, adsorbent and demulscent therapeutically. Polyethylene glycol dimethyl ether 500 is used as permeation enhancer.Mucoadhesive buccal tablets of insulin are prepared by direct compression method. Buccal tablets are evaluated by certain parameters like dissolution, in vitro bioadhesion study drug permeation study and in vivo study. Results revealed that the tablet containing 5mg locust bean gum and 4 mg PEG, DME500 as an ideal formulation for mucoadhesive buccal delivery of insulin.