Interleukin 1 Gene Cluster Polymorphisms and its Haplotypes may Predict the Risk to Develop Cervical Cancer in Tunisia
Our study aimed to evaluate the association between IL 1a (4845 G/T) IL 1b 511C/T) and IL 1RN (VNTR) polymorphisms and risk of cervical cancer. This case control study investigates three polymorphisms in 130 patients and 260 controls by PCR restriction fragment length polymorphism (RFLP) The IL 1RN (VNTR) A1/A3 genotype appear as a cervical cancer risk factor (p 0.048; OR 2.92; 95 CI 1.00 8.74) moreover, the L/2* decreased the risk (p 0.011; OR 0.47; 95 CI 0.25 0.88) and may be a protective factor against this pathology. Stratified analysis according to the FIGO stage subgroup revealed that the IL 1b 511 T/T genotype and T allele may be a protective factors against cervical cancer development for patients with early stage (p 0.030; OR 0.46; 95 CI 0.22 0.96) (p 0.020; OR 0.68; 95 CI 0.48 0.97) However, for the patients with advanced FIGO stage, IL 1RN VNTR L/2* genotype appear as a protective factor for this pathology (p 0.023; OR 0.29; 95 CI 0.08 0.99) The (G T L) haplotype showed a significant decreased frequency in cervical cancer patients as compared to controls (p 0.032; OR 0.53; 95 CI 0.29 0.95) In contrast, the (T T 2* combination appear a risk factor for the development of cervical cancer (p 0.018; OR 1.57; 95 CI 1.07 2.30) Our study suggested that IL1 cluster polymorphisms and haplotypes may be a genetic risk factor for cervical cancer.
Pathology Oncology Research