Evaluation of SUV normalized by lean body mass (SUL) in 68Ga PSMA11 PET/CT: a bi centric analysis
IntroductionThe aim of this analysis was to investigate whether the standardized uptake value (SUV) normalized by lean body mass (SUL) is a more appropriate quantitative parameter compared to the commonly used SUV normalized by patient's weight in 68Ga PSMA11 PET/CT.Material and methods68Ga PSMA11 PET/CT scans of 121 patients with prostate cancer from two institutions were evaluated. Liver SUV was measured within a 3 cm volume of interest (VOI) in the right hepatic lobe and corrected for lean body mass using the Janmahasatian formula. SUV and SUL repeatability between baseline and follow up scans of the same patients were assessed.ResultsSUV was significantly positively correlated with body weight (r 0.35, p 0.02) In contrast, SUL was not correlated with body weight (r 0.23, p 0.07) No significant differences were found between baseline and follow up scan (p 0.52).ConclusionThe Janmahasatian formula annuls the positive correlations between SUV and body weight, suggesting that SUL is preferable to SUV for quantitative analyses of 68Ga PSMA11 PET/CT scans.
EJNMMI Research