Effect of PLGA polymer on Antimicrobial Activity and the Release Studies of Nanoparticle Hydrogel Containing Mimosa pudica Extract
In the present study an attempt was made to formulate hydrogel containing Mimosa pudica extracts and was evaluated for its antimicrobial activity. The chemical consitutents was extracted by cold maceration in ethanol. Polymeric PLGA nanoparticles were formulated and incorporated into gel matrix, using HPMC K4M as base. Nanoparticulate hydrogel formulations exhibited high viscosity, neutral pH with good spreadability which is appropriate for transdermal application. In vitro drug release showed prolonged drug release from optimized formulation up to 24 h. The antimicrobial evaluation was done using cup plate method for zone of inhibition. Zone of inhibition of plant extracts was studied prior to gel formulation to compare the changes in activity after incorporation into hydrogel. Activity of plant extracts was not much affected by incorporation in hydrogel. The hydrogel showed promising antibacterial activity against other strains of S. Aureus.