An efficient and versatile approach for optical resolution of C2 symmetric axially chiral biaryl dials. Synthesis of enantiopure biaryl derived cyclic trans 1,2 diols.
An efficient and practical method for optical resolution of axially chiral biaryl dials using enantiomeric tert butanesulfinamide as resolving agent was developed. The approach offers a very convenient and straightforward access to versatile enantiomerically pure C2 symmetric biaryl dials in good yields. With the obtained axially chiral dials, stereoselective synthesis of a series of cyclic trans 1,2 diols in optically pure form was investigated.
Organic letters