Ti OMo Biao Mian Gu Ding Bu Tong Shou Xing Jiu Shi Suan Ji Qi Xie Ye Xiang Rong Xing Ping Jie Immobilization of Different Chiral Tartaric Acid on Ti O Surface and Blood Compatibility Evaluation
Shou Xing Shi Sheng Ming Ti Xi De Ji Ben Te Zheng ,Sheng Ming Ti Xi Ju You Gao Du De Shou Xing Xuan Ze Xing ,Biao Mian Shou Xing Ke Neng Xian Zhu Ying Xiang Sheng Wu Cai Liao De Sheng Wu Xue Gong Neng Ben Wen Jiang Bu Tong Shou Xing Jiu Shi Suan Fen Zi Gu Ding Zai Ti OMo Biao Mian ,Huo De Liao Bu Tong Shou Xing Biao Mian XPSJian Ce Jie Guo Xian Shi ,Chen Ji Liao Duo Ba E De Yang Pin Biao Mian Chu Xian Liao Xin De N1sFeng ,Jie Zhi Liao Ji Er E De Yang Pin Biao Mian N:CZhi Sheng Gao ,Sui Hou You Yin Wei Jie Zhi Liao Shou Xing Jiu Shi Suan ,Qi Biao Mian De O:CZhi Sheng Gao ,XPSJie Guo Biao Ming Ge Ceng Ci Biao Mian Jun Yi Zhi Bei Cheng Gong Shui Jie Hong Jiao Jian Ce Jie Guo Xian Shi ,L Jiu Shi Suan Biao Mian He D Jiu Shi Suan Biao Mian De Shui Jie Hong Jiao Ji Hu Mei You Chai Yi ,Shuo Ming Biao Mian Shou Xing Bu Hui Ying Xiang Cai Liao Biao Mian De Qin Shu Shui Xing Tong Guo Xian Wei Dan Bai Yuan Bian Xing Shi Yan He Ti Wai Xie Xiao Ban Nian Fu Yu Ji Huo Shi Yan Lai Ping Jie Shou Xing Dui Yu Cai Liao Biao Mian Xie Ye Xiang Rong Xing De Ying Xiang Xiang Dui Yu L Jiu Shi Suan Biao Mian ,D Jiu Shi Suan Biao Mian Xian Shi Chu Jiao Di De Xian Wei Dan Bai Yuan Bian Xing Cheng Du ,Bing Qie Xie Xiao Ban De Nian Fu Liang Geng Shao ,Xie Xiao Ban Bei Ji Huo De Cheng Du Geng Di Zhe Xie Jie Guo Biao Ming Shou Xing Dui Yu Sheng Wu Cai Liao De Kang Ning Xie Xing Neng You Zhao Bu Rong Hu Shi De Ying Xiang ,Wei Kai Fa Xing Neng You Yi De Kang Ning Xie Cai Liao Ti Gong Liao Xin De Si Lu Chirality is one of the basic characteristics of life system, which has a high degree of chiral selectivity, surface chirality may significantly affect the biological function of biomaterials. In this paper, different chiral tartaric acid molecules were immobilized on the surface of Ti O films. XPS test results showed the peak of nitrogen appeared on the samples which had deposited dopamine, the ratio of nitrogen to carbon was increased when hexamethylendiamine was introduced. When chiral tartaric acid was grafted, the ratio of oxygen to carbon was increased. XPS results showed that all surfaces had been successfully prepared. The water contact angle test results showed that no difference was present on the L surface and D surface, indicating that surface chirality had little effect on surface hydrophobicity. The effects of chirality on the blood compatibility of materials were evaluated by fibrinogen denaturation test and platelet adhesion and activation assay in vitro. Compared with L tartaric acid surface, D tartaric acid surface showed a lower degree of denatura tion of fibrinogen, less platelet adhesion and a lower degree of platelet activation. These results indicate that chirality cannot be ignored in the anticoagulant properties of biomaterials, which provides a new idea for the development of anticoagulant materials with excellent properties.