Dissecting the pathophysiology of immune thrombotic thrombocytopenic purpura: interplay between genes and environmental triggers
"Activation of ADAMTS13 specific CD4+ T cells requires uptake of ADAMTS13 by antigen presenting cells (APCs) and presentation of ADAMTS13 derived peptides on HLA molecules. As the HLA DRB1*11 was identified as a risk factor for the development of iTTP, investigation of ADAMTS13 derived peptides that are preferentially presented on MHC class II of healthy individuals positive for this allele was performed."
Haematologica