Wnt signaling pathway in development and cancer.
Wnt signaling pathway is one of the most important signaling pathways. The complexity of Wnt signals and their functional role is crucial in development and growth. It is the most active during embryogenesis facilitating new organism formation by cell differentiation, polarization and migration. Its activation is also common during development of many tumors and others diseases. In this review we shortly describe a role of Wnt pathway in development in order to better understand its role in cancer progression. We also describe current anti cancer therapies targeting Wnt pathway.
Journal of physiology and pharmacology an official journal of the Polish Physiological Society