Suppression of TLR4 by miR 448 is involved in Diabetic development via regulating Macrophage polarization
Lipopolysaccharide (LPS) contributed to the development and progression of type 2 diabetes mellitus (T2D) while TLR4 is reported to mediate the LPS induced inflammation in macrophages. However, the potential molecular mechanisms for TLR4 mediated macrophages activation in T2D have not yet to be fully clarified.
The Journal of pharmacy and pharmacology