Value of pathogenic diagnosis of 18F FDG PET/CT imaging in non traumatic unilateral vocal cord paralysis
Objective To evaluate the diagnostic value of 18F fluorodeoxyglucose (FDG) PET/CT imaging in non traumatic unilateral vocal cord paralysis (UVCP) and compare the radioactive uptake in different lesions. Methods Clinical data of 62 patients (49 males, 13 females; age: (61.7+ 12.8) years) with non traumatic UVCP (43 cases of left vocal cord paralysis and 19 cases of right) admitted to Ji'an Hospital from January 2016 to December 2018 were analyzed retrospectively. Pathological results, imaging or follow up results were considered as the standard of final diagnosis. The diagnostic efficacy of PET/CT imaging for the primary cause was analyzed. The maximum standardized uptake values (SUVmax) of vocal cord in patients with different etiology were compared by independent sample t test. Results According to the final diagnosis, the primary causes of UVCP were as follows: malignant tumors (n=44) inflammation (n=16) glomus jugulare tumor (n=1) and idiopathic UVCP (n=1) The diagnostic accuracy of PET/CT imaging for the primary cause was 90.32%(56/62) 44 cases were correctly diagnosed as malignant tumors, while 11 cases as inflammation, and 1 case as glomus jugulare tumor. Among 62 patients, 29 patients had increased SUVmax in the affected side (direct invasion group; further divided into tumor group (n=12) and non tumor group (n=17) and other 33 patients had increased SUVmax in the healthy side (indirect invasion group) SUVmax of the affected vocal cord in direct invasion group was higher than that in the healthy side (9.97+ 5.21 vs 2.43+ 0.62; t=8.14, P 0.05) Conclusions 18F FDG PET/CT imaging has high diagnostic value in pathogenic diagnosis of non traumatic UVCP. The different radioactive uptake of vocal cords in the affected side and the healthy side provides more accurate etiological information for clinical analysis. Key words: Vocal cord paralysis; Positron emission tomography; Tomography, X ray computed; Deoxyglucose