Darwinolide, a New Diterpene Scaffold That Inhibits Methicillin Resistant Staphylococcus aureus Biofilm from the Antarctic Sponge Dendrilla membranosa
A new rearranged spongian diterpene, darwinolide, has been isolated from the Antarctic Dendroceratid sponge Dendrilla membranosa. Characterized on the basis of spectroscopic and crystallographic analysis, the central seven membered ring is hypothesized to originate from a ring expansion of a spongian precursor. Darwinolide displays 4 fold selectivity against the biofilm phase of methicillin resistant Staphylococcus aureus compared to the planktonic phase and may provide a scaffold for the development of therapeutics for this difficult to treat infection.
Organic letters