Immune Thrombocytopenic Purpura (ITP) Triggered by COVID 19 Infection and Vaccination.
I thrombocytopenia (ITP) is an autoimmune condition caused by the inhibition of platelet production and circulation by autoantibodies. It presents clinically as minor to major bleeding secondary to the thrombocytopenia [1] The most common form of ITP is idiopatic, but it has been described following various infections and drugs, and most recently, vaccinations [1] Since the beginning of the coronavirus disease 2019 (COVID 19) pandemic in December 2019, the severe acute respiratory syndrome coronavirus 2 (SARS CoV 2) was postulated as a potential trigger to numerous autoimmune disorders [2] Specifically ITP has been reported following SARS CoV 2 infection [3] Different vaccines against the infection were given worldwide in an attempt to control the SARS CoV 2 pandemic, raising the question of whether ITP may also result from COVID 19 vaccination, in addition to the infection.
The Israel Medical Association journal IMAJ