Polar steroid derivatives from the Vietnamese starfish Astropecten polyacanthus
Abstract Five polar steroid derivatives, including one new glycosylated polyhydroxysteroid namely polyacanthoside A (1) were isolated from the water soluble materials from the MeOH extract of the Vietnamese starfish Astropecten polyacanthus using various chromatographic separations. The structure elucidation was confirmed by spectroscopic experiments such as HR ESI MS, 1D and 2D NMR. Among the isolated compounds, (20R,24S) 3b,6a,8,15b,24 pentahydroxy 5a cholestane (3) showed significant cytotoxic effect against five human cancer cell lines as HepG2, KB, LNCaP, MCF7 and SK Mel2 with the IC50 values from 18.03 2.63 to 21.59 3.23 mM.
Natural product research