NF2 Inhibits Proliferation and Cancer Stemness in Breast Cancer
Abstract Background Previous studies have shown that NF2 plays a key role in tumorigenesis. NF2 has been illustrated to be downregulated in several types of human cancer. However, the role of NF2 in breast cancer remains unclear. Methods We used UALCAN and KM plotter database to study NF2 expression in human breast cancer and corresponding normal tissues and analyzed its relationship with clinicopathological parameters. We investigated the role of NF2 in breast cancer cells behavior by inhibiting its expression in MDA MB 231 and MCF 7 cells. Results In this study, we found that NF2 was downregulated in breast cancer tissues compared to the adjacent normal tissues. We found that the low expression of NF2 was related with the tumor stage. NF2 overexpression inhibited the cell colon formation and stemness. Conclusion Our results indicate a role of NF2 in the progression of breast cancer.
Open medicine