Boosting MAIT cells as immunotherapy: context is everything
INTRODUCTION The abundance of mucosal associated invariant T (MAIT) cells, their strong evolutionary conservation and innate like effector functions have made them a focus of much research attention over the past decade. However, this biology has yet to see clinical translation. Sakai et al. present exciting murine data showing a differential effect of enhancing MAIT cells at different stages of infection with Mycobacterium tuberculosis (M.tb) with a tantalising suggestion of how MAIT cells could be modulated therapeutically.
Mucosal Immunology