Organocatalytic Mitsunobu Reactionswith 3,5 Dinitrobenzoic Acid
A second generation procedure for organocatalytic Mitsunobu reactions using 3,5 dinitrobenzoic acid as the pro nucleophile has been developed. The increased acidity of this acid compared to 4 nitrobenzoic acid, which was used in the original procedure, allowed for higher isolated yields of the desired products and eliminated formation of undesired acetate byproducts.