Hollow MnO2 as a tumor microenvironment responsive biodegradable nano platform for combination therapy favoring antitumor immune responses
Herein, an intelligent biodegradable hollow manganese dioxide (H MnO2) nano platform is developed for not only tumor microenvironment (TME) specific imaging and on demand drug release, but also modulation of hypoxic TME to enhance cancer therapy, resulting in comprehensive effects favoring anti tumor immune responses. With hollow structures, H MnO2 nanoshells post modification with polyethylene glycol (PEG) could be co loaded with a photodynamic agent chlorine e6 (Ce6) and a chemotherapy drug doxorubicin (DOX) The obtained H MnO2 PEG/C&D would be dissociated under reduced pH within TME to release loaded therapeutic molecules, and in the meantime induce decomposition of tumor endogenous H2O2 to relieve tumor hypoxia. As a result, a remarkable in vivo synergistic therapeutic effect is achieved through the combined chemo photodynamic therapy, which simultaneously triggers a series of anti tumor immune responses. Its further combination with checkpoint blockade therapy would lead to inhibition of tumors at distant sites, promising for tumor metastasis treatment.MnO2 nanostructures are promising TME responsive theranostic agents in cancer. Here, the authors develop a nano platform based on hollow H MnO2 nanoshells able to modulate the tissue microenvironment, release a drug and inhibit tumor growth alone or in combination with check point blockade therapy.
Nature Communications