Research on the relationship between estrogen receptor polymorphisms and female postmeno pausal osteoporosis and the relevant factors in Wenzhou
Objective: To probe the relationship between postmenopausal osteoporosis(PMOP)and the estrogen receptor a gene polymorphisms and other relevant factors.Methods: Two hundred and three postmenopausal women were randomly selected and devided into nomal control group,bone loss group and PMOP group.Lumbar BMD was measured,and genotypes were detected.Meanwhile,the dietary behavior and exercise of the women were also surveyed.Results: Age,lower educational level.shorter height,lower weight,BMI,more pregnancies and childbirth were related with PMOP.Intake of more milk,soy milk,tea,sea food,beans or bean products,meet,eggs,fruit,nuts and more exercise monthly were associated with high BMD.The frequencies distribution of PvuII was PP:26.6%,pp:27.6% and Pp:45.8%,respectively,and the frequencies distribution of XbaI was XX:9.9%,xx:57.1% and Xx:33%,respectively.Logistic regression indicated that age,coffee and XbaI XX were the risk factors of bone loss,the high degree of culture,BMI,often drinking tea or intake of fruit were the protection factors of PMOP.Conclusion: The frequen cies distribution of ERa is different from other regions,and the relationship between BMD is not clear,the predictive value on PMOP remains to need further study.Close relationship between and dietary behavior and environmental factors is found in our rcescarch.