Plasmid Mediated mcr 1 Colistin Resistance in Escherichia coli from a Black Kite in Russia
The gene mcr 1 conferring resistance to last line antibiotic colistin has been reported globally. Here, we describe the first detection of plasmid mediated colistin resistance in Russian wildlife, an isolate of Escherichia coli sequence type 2280 from a black kite (Milvus migrans) scavenging raptor. Whole genome sequencing and plasmid transferability experiments revealed that mcr 1.1 was located on conjugative IncI2 plasmid pDR164 (59891 bp) ABSTRACT The gene mcr 1 conferring resistance to last line antibiotic colistin has been reported globally. Here, we describe the first detection of plasmid mediated colistin resistance in Russian wildlife, an isolate of Escherichia coli sequence type 2280 from a black kite (Milvus migrans) scavenging raptor. Whole genome sequencing and plasmid transferability experiments revealed that mcr 1.1 was located on conjugative IncI2 plasmid pDR164 (59891 bp) Migratory black kites may contribute to the global spread of mobile colistin resistance.
Antimicrobial Agents and Chemotherapy