Deep Convolutional Neural Networks for Computer Aided Detection: CNN Architectures, Dataset Characteristics and Transfer Learning
Remarkable progress has been made in image recognition, primarily due to the availability of large scale annotated datasets and deep convolutional neural networks (CNNs) CNNs enable learning data driven, highly representative, hierarchical image features from sufficient training data. However, obtaining datasets as comprehensively annotated as ImageNet in the medical imaging domain remains a challenge. There are currently three major techniques that successfully employ CNNs to medical image classification: training the CNN from scratch, using off the shelf pre trained CNN features, and conducting unsupervised CNN pre training with supervised fine tuning. Another effective method is transfer learning, i.e. fine tuning CNN models pre trained from natural image dataset to medical image tasks. In this paper, we exploit three important, but previously understudied factors of employing deep convolutional neural networks to computer aided detection problems. We first explore and evaluate different CNN architectures. The studied models contain 5 thousand to 160 million parameters, and vary in numbers of layers. We then evaluate the influence of dataset scale and spatial image context on performance. Finally, we examine when and why transfer learning from pre trained ImageNet (via fine tuning) can be useful. We study two specific computer aided detection (CADe) problems, namely thoraco abdominal lymph node (LN) detection and interstitial lung disease (ILD) classification. We achieve the state of the art performance on the mediastinal LN detection, and report the first five fold cross validation classification results on predicting axial CT slices with ILD categories. Our extensive empirical evaluation, CNN model analysis and valuable insights can be extended to the design of high performance CAD systems for other medical imaging tasks.
Ieee Transactions on Medical Imaging