Modern nutrigenomics and nutrigenetics and some metabolic aspects of pathogenesis in inflammatory bowel diseases: a look into the future
The implementation of the target setting for the treatment of inflammatory bowel diseases the achievement of clinical and endoscopic remission in each case, even taking into account biological therapy drugs, is not always achievable. It is obvious that patients with ulcerative colitis and Crohn's disease are genetically heterogeneous in nature, which is manifested by the formation of various clinical and genetic phenotypes and various profiles of altered intestinal microbiota. Modern dietetics and nutritionology can be the most important fine tuning tool in this chain of events and significantly increase the effectiveness of the therapy, equally contributing to both normalization of the intestinal microbial community and providing mechanisms for regulating gene expression (epigenetic effect)