Airways remodeling is reversed by aerobic training in an asthma animal model
Aerobic training (AT) reverses airway remodeling in murine model of asthma; however the effects triggered by AT are poorly known. Aim: Evaluate the effect of AT in airway remodeling and fibrosis mediators in an asthma model. Method: 32 Balb/c mice were divided in 4 groups (n=8) Control (CT) AT, Ovalbumin (OVA) OVA+AT. OVA groups received 4 i.p. OVA+Al(OH) 3 and OVA inhalations (1 3% 15 sessions, 30 min. 3xWk) that was maintained during AT. AT (50% max. exercise capacity; 60 min. begun after chronic airway inflammation and it was performed for 4 weeks. After that, tissue lung was collected to evaluated airway smooth muscle (ASM) and epithelium thickness, collagen and elastic fibers contents and mucus expression in the airways evaluated by image analyses. It was also evaluated eosinophil and neutrophil counting and IL 5, OPN, VEGF,TGF b, MMP 9, TIMP 1 by immnunohistochemistry in lung tissues slices. Result: Sensitized groups presented an increase of eosinophil and neutrophils, airway remodeling features and the expression of IL 5, OPN, VEGF, TGF b, MMP 9 and TIMP 2 *p