The protective effect of epigallocatechin gallate on renal ischemia reperfusion injury in rats
Objective To study the protective effect of epigallocatechin gallate(EGCG)on renal ischemia reperfusion injury in rats.Methods Twelve Lewis rats were divided into 2 groups:the ex perimental group(n 7)was intravenously administered with ECCG at the dose of 10 mg/kg during the reperfusion period,and the remaining rats served as control group.At the end of reperfusion period,all the rats were sacrificed.Blood and kidney samples were collected for the blood levels of creatinine and urea nitrogen,the tissue concentration of malondialdehyde(MDA)and superoxide dis mutase(SOD)and pathological studies.Results The blood levels of creatinine and urea nitrogen in experimental group were lower than in control group(P0.05).The tissue concentrations of MDA and SOD in experimental group was reduced and increased,respectively,as compared with control group(P0.01).Pathological studies indicated that EGCG could attenuate the ischemia reperfusion injury in rats.Conclusion EGCG is a promising agent,which can be implicated into the therapy for ischemia and reperfusion injury.