Tunable resistive pulse sensing (TRPS)
Abstract TRPS is an experimental technique of growing popularity that has been used to measure a range of synthetic and biological colloidal particles, including drug delivery particles, DNA, viruses, and bacteria, among other analytes. Based upon the Coulter method for counting particles, TRPS has the unique capability of measuring a wide range of particles, from ca. 40 nm up to the size of cells, finding numerous applications in nanomedicine and biotechnology. The primary aim of this chapter is to provide a guide that focuses on the use of TRPS technology for particle characterization together with some trouble shooting methods. General TRPS protocols to determine particle size, size distribution, z potential, and concentration are included, and selected comparison studies of TRPS technology with other associated analytical techniques are also presented here.