8930290
Data mining of gene expression changes in Alzheimer brain
Genome-wide transcription profiling is a powerful technique for studying the enormous complexity of cellular states. Moreover, when applied to disease tissue it may reveal quantitative and qualitative alterations in gene expression that give information on the context or underlying basis for the disease and may provide a new diagnostic approach. However, the data obtained from high-density microarrays is highly complex and poses considerable challenges in data mining. The data requires care in both pre-processing and the application of data mining techniques. This paper addresses the problem of dealing with microarray data that come from two known classes (Alzheimer and normal). We have applied three separate techniques to discover genes associated with Alzheimer disease (AD). The 67 genes identified in this study included a total of 17 genes that are already known to be associated with Alzheimer's or other neurological diseases. This is higher than any of the previously published Alzheimer's studies. Twenty known genes, not previously associated with the disease, have been identified as well as 30 uncharacterized expressed sequence tags (ESTs). Given the success in identifying genes already associated with AD, we can have some confidence in the involvement of the latter genes and ESTs. From these studies we can attempt to define therapeutic strategies that would prevent the loss of specific components of neuronal function in susceptible patients or be in a position to stimulate the replacement of lost cellular function in damaged neurons. Although our study is based on a relatively small number of patients (four AD and five normal), we think our approach sets the stage for a major step in using gene expression data for disease modeling (i.e. classification and diagnosis). It can also contribute to the future of gene function identification, pathology, toxicogenomics, and pharmacogenomics.
8336028
Evaluation and optimization of clustering in gene expression data analysis
MOTIVATION
A measurement of cluster quality is needed to choose potential clusters of genes that contain biologically relevant patterns of gene expression. This is strongly desirable when a large number of gene expression profiles have to be analyzed and proper clusters of genes need to be identified for further analysis, such as the search for meaningful patterns, identification of gene functions or gene response analysis.


RESULTS
We propose a new cluster quality method, called stability, by which unsupervised learning of gene expression data can be performed efficiently. The method takes into account a cluster's stability on partition. We evaluate this method and demonstrate its performance using four independent, real gene expression and three simulated datasets. We demonstrate that our method outperforms other techniques listed in the literature. The method has applications in evaluating clustering validity as well as identifying stable clusters.


AVAILABILITY
Please contact the first author.
3756850
Clustering algorithms for content-based publication-subscription systems
We consider efficient communication schemes based on both network-supported and application-level multicast techniques for content-based publication-subscription systems. We show that the communication costs depend heavily on the network configurations, distribution of publications and subscriptions. We devise new algorithms and adapt existing partitional data clustering algorithms. These algorithms can be used to determine multicast groups with as much commonality as possible, based on the totality of subscribers' interests. They perform well in the context of highly heterogeneous subscriptions, and they also scale well. An efficiency of 60% to 80% with respect to the ideal solution can be achieved with a small number of multicast groups (less than 100 in our experiments). Some of these same concepts can be applied to match publications to subscribers in real-time, and also to determine dynamically whether to unicast, multicast or broadcast information about the events over the network to the matched subscribers. We demonstrate the quality of our algorithms via simulation experiments.
7550543
A digital library for geography examination resources
We describe a Web-based application developed above a digital library of geographical resources for Singapore students preparing to take a national examination in geography. The application provides an interactive, non-sequential approach to learning that supplements textbooks.
2853015
On the capacity of hybrid wireless networks
This paper involves the study of the throughput capacity of hybrid wireless networks. A hybrid network is formed by placing a sparse network of base stations in an ad hoc network. These base stations are assumed to be connected by a high-bandwidth wired network and act as relays for wireless nodes. They are not data sources nor data receivers. Hybrid networks present a tradeoff between traditional cellular networks and pure ad hoc networks in that data may be forwarded in a multihop fashion or through the infrastructure. It has been shown that the capacity of a random ad hoc network does not scale well with the number of nodes in the system. In this work, we consider two different routing strategies and study the scaling behavior of the throughput capacity of a hybrid network. Analytical expressions of the throughput capacity are obtained. For a hybrid network of n nodes and m base stations, the results show that if m grows asymptotically slower than √n, the benefit of adding base stations on capacity is insignificant. However, if m grows faster than √n, the throughput capacity increases linearly with the number of base stations, providing an effective improvement over a pure ad hoc network. Therefore, in order to achieve nonnegligible capacity gain, the investment in the wired infrastructure should be high enough.
16465387
Rapid modeling of animated faces from video
Generating realistic 3D human face models and facial animations has been a persistent challenge in computer graphics. We have developed a system that constructs textured 3Dface models from videos with minimal user interaction. Our system takes images andvideo sequences of a face with an ordinary video camera. After five manual clicks ontwo images to tell the system where the eye corners, nose top and mouth corners are, thesystem automatically generates a realistic looking 3D human head model and the constructed model can be animated immediately. A user with a PC and an ordinary camera can use our system to generate his/her face model in a few minutes. Copyright © 2001 John Wiley & Sons, Ltd.
5156351
Model-based bundle adjustment with application to face modeling
We present a new model-based bundle adjustment algorithm to recover the 3D model of a scene/object from a sequence of images with unknown motions. Instead of representing scene/object by a collection of isolated 3D features (usually points), our algorithm uses a surface controlled by a small set of parameters. Compared with previous model-based approaches, our approach has the following advantages. First instead of using the model space as a regularizer we directly use it as our search space, thus resulting in a more elegant formulation with fewer unknowns and fewer equations. Second, our algorithm automatically associates tracked points with their correct locations on the surfaces, thereby eliminating the need for a prior 2D-to-3D association. Third, regarding face modeling, we use a very small set of face metrics (meaningful deformations) to parameterize the face geometry, resulting in a smaller search space and a better posed system. Experiments with both synthetic and real data show that this new algorithm is faster, more accurate and more stable than existing ones.