40143819
Efficient Filtering of Large DatasetA User-Centric Paradigm
5788516
Efficient genome ancestry inference in complex pedigrees with inbreeding
Motivation: High-density SNP data of model animal resources provides opportunities for fine-resolution genetic variation studies. These genetic resources are generated through a variety of breeding schemes that involve multiple generations of matings derived from a set of founder animals. In this article, we investigate the problem of inferring the most probable ancestry of resulting genotypes, given a set of founder genotypes. Due to computational difficulty, existing methods either handle only small pedigree data or disregard the pedigree structure. However, large pedigrees of model animal resources often contain repetitive substructures that can be utilized in accelerating computation. Results: We present an accurate and efficient method that can accept complex pedigrees with inbreeding in inferring genome ancestry. Inbreeding is a commonly used process in generating genetically diverse and reproducible animals. It is often carried out for many generations and can account for most of the computational complexity in real-world model animal pedigrees. Our method builds a hidden Markov model that derives the ancestry probabilities through inbreeding process without explicit modeling in every generation. The ancestry inference is accurate and fast, independent of the number of generations, for model animal resources such as the Collaborative Cross (CC). Experiments on both simulated and real CC data demonstrate that our method offers comparable accuracy to those methods that build an explicit model of the entire pedigree, but much better scalability with respect to the pedigree size. Contact: weiwang@cs.unc.edu
7408751
Quantitative Association Analysis Using Tree Hierarchies
Association analysis arises in many important applications such as bioinformatics and business intelligence. Given a large collection of measurements over a set of samples, association analysis aims to find dependencies of target variables to subsets of measurements. Most previous algorithms adopt a two-stage approach; they first group samples based on the similarity in the subset of measurements, and then they examine the association between these groups and the specified target variables without considering the inter-group similarities or alternative groupings. This can lead to cases where the strength of association depends significantly on arbitrary clustering choices. In this paper, we propose a tree-based method for quantitative association analysis. Tree hierarchies derived from sample similarities represent many possible sample groupings. They also provide a natural way to incorporate domain knowledge such as ontologies and to identify and remove outliers. Given a tree hierarchy, our association analysis evaluates all possible groupings and selects the one with strongest association to the target variable. We introduce an efficient algorithm, TreeQA, to systematically explore the search-space of all possible groupings in a set of input trees, with integrated permutation tests. Experimental results show that TreeQA is able to handlelarge-scale association analysis very efficiently and is more effective and robust in association analysis than previous methods.
62615149
Mining Asynchronous Periodic Patterns in Time Series Data
Periodicy detection in time series data is a challenging problem of great importance in many applications. Most previous work focused on mining synchronous periodic patterns and did not recognize the misaligned presence of a pattern due to the intervention of random noise. In this paper, we propose a more flexible model of asynchronous periodic pattern that may be present only within a subsequence and whose occurrences may be shifted due to disturbance. Two parameters min/spl I.bar/rep and max/spl I.bar/dis are employed to specify the minimum number of repetitions that is required within each segment of nondisrupted pattern occurrences and the maximum allowed disturbance between any two successive valid segments. Upon satisfying these two requirements, the longest valid subsequence of a pattern is returned. A two-phase algorithm is devised to first generate potential periods by distance-based pruning followed by an iterative procedure to derive and validate candidate patterns and locate the longest valid subsequence. We also show that this algorithm cannot only provide linear time complexity with respect to the length of the sequence but also achieve space efficiency.
14969897
Dynamic adaptive file management in a local area network
In light of advances in processor and networking technology, especially the emergence of network attached disks, the traditional client-server architecture of file systems has become suboptimal for many computation/data intensive applications. We introduce a revised architecture for file management employing network attached storage: the dynamic file server environment (Dynamo). Dynamo introduces two main architectural innovations: to provide high scalability, the file management functions are mainly performed cooperatively by the clients in the system. Furthermore, data is transferred directly to the client's cache from network-attached disks, thus avoiding copies from a disk to the server buffer and then over the network to the client. Secondly, Dynamo uses a cooperative cache management which employs a decentralized lottery-based page replacement strategy. We show via performance benchmarks run on the Dynamo system and simulation results how this architecture increases the system's adaptability, scalability and cost performance.
2548187
Mining asynchronous periodic patterns in time series data
Periodicy detection in time series data is a challenging problem of great importance in many applications. Most previous work focused on mining synchronous periodic patterns and did not recognize the misaligned presence of a pattern due to the intervention of random noise. In this paper, we propose a more flexible model of asynchronous periodic pattern that may be present only within a subsequence and whose occurrences may be shifted due to disturbance. Two parameters min rep and max dis are employed to specify the minimum number of repetitions that is required within each segment of nondisrupted pattern occurrences and the maximum allowed disturbance between any two successive valid segments. Upon satisfying these two requirements, the longest valid subsequence of a pattern is returned. A two-phase algorithm is devised to first generate potential periods by distance-based pruning followed by an iterative procedure to derive and validate candidate patterns and locate the longest valid subsequence. We also show that this algorithm cannot only provide linear time complexity with respect to the length of the sequence but also achieve space
1582891
Lazy Updates: An Efficient Technique to Continuously Monitoring Reverse kNN
In this paper, we study the problem of continuous monitoring of reverse k nearest neighbor queries. Existing continuous reverse nearest neighbor monitoring techniques are sensitive towards objects and queries movement. For example, the results of a query are to be recomputed whenever the query changes its location. We present a framework for continuous reverse k nearest neighbor queries by assigning each object and query with a rectangular safe region such that the expensive recomputation is not required as long as the query and objects remain in their respective safe regions. This significantly improves the computation cost. As a by-product, our framework also reduces the communication cost in client-server architectures because an object does not report its location to the server unless it leaves its safe region or the server sends a location update request. We also conduct a rigid cost analysis to guide an effective selection of such rectangular safe regions. The extensive experiments demonstrate that our techniques outperform the existing techniques by an order of magnitude in terms of computation cost and communication cost.
6226035
Online and adaptive anomaly Detection: detecting intrusions in unlabelled audit data streams
Disclosed is a method of lowering the prolactin level in the blood or serum of a person which method comprises administering a therapeutically effective amount of 2-amino-6-allyl-5,6,7,8-tetrahydro-4H-thiazolo-[5,4-d]azepine or a non-toxic, pharmaceutically acceptable acid addition salt thereof.
24206437
Chopper: Efficient algorithm for tree mining
With the development of Internet, frequent pattern mining has been extended to more complex patterns like tree mining and graph mining. Such applications arise in complex domains like bioinformatics, web mining, etc. In this paper, we present a novel algorithm, namedChopper, to discover frequent subtrees from ordered labeled trees. An extensive performance study shows that the newly developed algorithm outperformsTreeMiner V, one of the fastest methods proposed previously, in mining large databases. At the end of this paper, the potential improvement ofChopper is mentioned.
30881426
Constraint-Based Graph Mining in Large Database
Currently, constraints are increasingly considered as a kind of means of user- or expert-control for filtering those unsatisfied and redundant patterns rapidly during the web mining process. Recent work has highlighted the importance of constraint-based mining paradigm in the context of frequent itemsets, sequences, and many other interesting patterns in large database. However, it is still not clear how to push various constraints systematically into graph mining process. In this paper, we categorize various graph-based constraints into several major classes and develop a framework CabGin (i.e. C onstr a int- b ased G raph M in ing) to push them into mining process by their categories. Non-monotonic aggregates like average also can be pushed into CabGin with minor revision. Experimental results show that CabGin can prunes a large search space effectively by pushing graph-based constraints into mining process.
16642996
Implementation and performance evaluation of Selective Repeat ARQ for WiMAX NS-2 model
With the steady development of WiMAX based broadband wireless access networks, complete and accurate simulation studies become crucial. In an effort to further improve our ns-2 simulation model for mobile WiMAX, we have implemented a selective repeat automatic retransmission request (SR-ARQ) mechanism into our model and evaluated its performance and accuracy. In this paper, we present the design and implementation methodology of the WiMAX SR-ARQ simulation model in ns-2 and discuss its accuracy via extensive simulation studies. Our evaluation clearly shows that SR-ARQ achieves increased successful packet delivery ratio and goodput, which is true for both non-saturated channels and saturated channels. In each case a cost of increased bandwidth consumption and latency overhead for received packets is also quantitatively analyzed. We believe the implementation of SR-ARQ in the ns-2 simulation model and its evaluation studies will provide profound empirical values to WiMAX field test studies.