877766
Inhibitory inputs increase a neurons's firing rate
Abstract Neurons are typically thought of as receiving information primarily through excitatory inputs, with inhibitory inputs playing a gating or regulating role. In this paper we demonstrate that increasing the strength of inhibitory inputs to the Hodgkin–Huxley and FitzHugh–Nagumo models can induce them to fire faster. This result is counter-intuitive and important in neural network modelling where inhibitory inputs are often neglected.
11160456
Structure of Lateral Inhibition in an Olfactory Bulb Model
It has been shown that mutual lateral inhibition of the projection neurones in the olfactory bulb, mediated by interneurones, serves to tune the representation of odours in the bulb and reduce the overlap between similaz odorants. In this paper we demonstrate that the parameters of the lateral interaction, specifically the relation of synaptic strength to cell separation and the effective overall gain of the network, have a significant effect on the strength and range of lateral inhibition in a simple model of the olfactory bulb.
7897839
Effects of Correlation and Degree of Balance in Random Synaptic Inputs on the Output of the Hodgkin-Huxley Model
We examine the effects of degree of balance between inhibitory and excitatory random synaptic inputs, and of positive correlation between the inputs on the mean and variability of the output of the classical Hodgkin-Huxley (HH) model for squid giant axon, using computer simulation. The mean interspike interval (ISI) and the coefficient of variation of ISI change little as the degree of balance changes, unlike the leaky integrate-and-fire model, frequently used in stochastic network modelling as an approximation to more biophysically based models. Low correlations (up to about 0.1) between 100 excitatory inputs each firing at 100 Hz reduce the mean(ISI) to below a third of its value when the inputs are independent, and CV by a factor of 5 from a near-Poisson range to one associated with regular firing.
206848726
Viewing a Class of Neurodynamics on Parameter Space
Nearly all models in neural networks start from the assumption that the input-output characteristic is a sigmoidal function. On parameter space we present a systematic and feasible method for analyzing the whole spectrum of attractors-all saturated, all-but-one saturated, all-but-two saturated, etc. — of a neurodynamical system with a saturated sigmoidal function as its input-output characteristic. We present an argument which claims, under a mild condition, that only all saturated or all-but-one saturated attractors are observable for the neurodynamics. For any given all saturated configuration ξ (all-but-one saturated configuration η) the paper shows how to construct an exact parameter region R(ξ) (¯R(η)) such that if and only if the parameters fall within R(ξ) (¯R(η)), then ξ (η) is an attractor (a fixed point) of the dynamics. The parameter region for an all saturated fixed point attractor is independent of the specific choice of a saturated sigmoidal function, whereas for an all-but-one saturated fixed point it is sensitive to the input-output characteristic.
10774169
Significance of random neuronal drive
Abstract Effectively random firing occurs frequently in the brain. Random components of neuronal drive are therefore often major influences on activity. We describe here how level of drive, inhibitory/excitatory balance, correlation between input streams, EPSP/IPSP characteristics, the nature of the postsynaptic neuron all affect pattern and level of firing, the influence often interacting in complex ways. Random firing might also be instrumental in facilitating synchronized firing. These factors are possibly important elements of the mechanisms by which some neural networks encode information. Clarifying them might therefore facilitate a deeper understanding of the nature of the neural code.
9793653
Paradoxical Relationship between Output and Input Regularity for the FitzHugh-Nagumo Model
We examine the effects of changing the coefficient of variation (CV) of the inter-stimulus interval on the CV of the output interspike interval (ISI), using constant magnitude, supra-threshold point-process stimuli of the membrane potential variable in the FitzHugh-Nagumo model. The coefficient of variation of the input is changed within the context of a displaced exponential distribution. We find that for some values of mean inter-stimulus interval, CV of ISI has an inverse relationship with input coefficient of variation, whereas for other mean stimulation rates, CV of ISI increases with input coefficient of variation. Over a wide range of input regularity CV of ISI is approximately constant, and is less than 0.4.
27826765
Analysing Flight Data Using Clustering Methods
This paper reviews existing forms of density-based, partitional and hierarchical clustering methods in the context of flight data analysis. Advantages and disadvantages are fully explored with a focus on proposing a clustering-based ensemble framework for monitoring flight data in order to search for anomalies during flight operation. Case studies in selected flight scenarios are provided to demonstrate the potential of clustering methods and their integration with reasoning techniques in detecting abnormal flights.
60537960
An orthodontic expert system
Abstract A Fuzzy Relational Inference Language, FRIL has been used to generate an expert system to help non-specialist dentists with orthodontic problems. The use of fuzzy relations, descriptors and numbers has been found useful in modelling the thought processes of orthodontic specialists.
9882695
Rigorously Defining and Analyzing Medical Processes: An Experience Report
This paper describes our experiences in defining the processes associated with preparing and administrating chemotherapy and then using those process definitions as the basis for analyses aimed at finding and correcting defects. The work is a collaboration between medical professionals from a major regional cancer center and computer science researchers. The work uses the Little-JIL language to create precise process definitions, the Propel system to specify precise process requirements, and the FLAVERS system to verify that the process definitions adhere to the requirement specifications. The paper describes how these technologies were applied to successfully identify defects in the chemotherapy process. Although this work is still ongoing, early experiences suggest that this approach can help reduce medical errors and improve patient safety. The work has also helped us to learn about the desiderata for process definition and analysis technologies, both of which are expected to be broadly applicable to other domains.
17110258
An ontology for scientific information in a Grid environment: the earth system Grid
In the emerging world of Grid Computing, shared computational, data, other distributed resources are becoming available to enable scientific advancement through collaborative research and collaboratories. This paper describes the increasing role of ontologies in the context of Grid Computing for obtaining, comparing and analyzing data. We present ontology entities and a declarative model that provide the outline for an ontology of scientific information. Relationships between concepts are also given. The implementation of some concepts described in this ontology is discussed within the context of the Earth System Grid II (ESG)[1].
19037738
The Virtualization Reality
A number of important challenges are associated with the deployment and configuration of contemporary computing infrastructure. Given the variety of operating systems and their many versions—including the often-specific configurations required to accommodate the wide range of popular applications—it has become quite a conundrum to establish and manage such systems.