121764664
The DIRC prototype for the WASA experiment at COSY
The implementation of a DIRC (Detector or Internally Reflected Cherenkov light) was planned for the WASA-at-COSY experiment, located at the Forschungszentrum Julich and is a major project for the future PANDA experiment at FAIR. In order to study the components and the behavior of the detector under experimental conditions, a large scale demonstrator made of acrylic glass was built and tested at the external proton beam of the COSY accelerator. The main properties of the components, especially of the newly developed front end electronics and the results of the first tests are presented.
122970197
Multijet production in neutral current deep inelastic scattering at HERA and determination of alpha(s)
Multijet production rates in neutral current deep inelastic scattering (DIS) have been measured in the range of exchanged boson virtualities 10<Q2<5000 GeV2. The data were taken at the ep collider HERA with centre-of-mass energy using the ZEUS detector and correspond to an integrated luminosity of 82.2 pb-1. Jets were identified in the Breit frame using the kT cluster algorithm in the longitudinally invariant inclusive mode. Measurements of differential multijet cross sections are presented as functions of jet transverse energy , pseudorapidity and Q2 with and . Next-to-leading-order QCD calculations describe the data well. The value of the strong coupling constant αs(MZ), determined from the ratio of the trijet to dijet cross sections, is .
36263241
New optimization methods for converging perturbative series with a field cutoff
We take advantage of the fact that in lambda phi ^4 problems a large field cutoff phi_max makes perturbative series converge toward values exponentially close to the exact values, to make optimal choices of phi_max. For perturbative series terminated at even order, it is in principle possible to adjust phi_max in order to obtain the exact result. For perturbative series terminated at odd order, the error can only be minimized. It is however possible to introduce a mass shift in order to obtain the exact result. We discuss weak and strong coupling methods to determine the unknown parameters. The numerical calculations in this article have been performed with a simple integral with one variable. We give arguments indicating that the qualitative features observed should extend to quantum mechanics and quantum field theory. We found that optimization at even order is more efficient that at odd order. We compare our methods with the linear delta-expansion (LDE) (combined with the principle of minimal sensitivity) which provides an upper envelope of for the accuracy curves of various Pade and Pade-Borel approximants. Our optimization method performs better than the LDE at strong and intermediate coupling, but not at weak coupling where it appears less robust and subject to further improvements. We also show that it is possible to fix the arbitrary parameter appearing in the LDE using the strong coupling expansion, in order to get accuracies comparable to ours.
24114301
Discovery of a selective inhibitor of oncogenic B-Raf kinase with potent antimelanoma activity
BRAFV600E is the most frequent oncogenic protein kinase mutation known. Furthermore, inhibitors targeting “active” protein kinases have demonstrated significant utility in the therapeutic repertoire against cancer. Therefore, we pursued the development of specific kinase inhibitors targeting B-Raf, and the V600E allele in particular. By using a structure-guided discovery approach, a potent and selective inhibitor of active B-Raf has been discovered. PLX4720, a 7-azaindole derivative that inhibits B-RafV600E with an IC50 of 13 nM, defines a class of kinase inhibitor with marked selectivity in both biochemical and cellular assays. PLX4720 preferentially inhibits the active B-RafV600E kinase compared with a broad spectrum of other kinases, and potent cytotoxic effects are also exclusive to cells bearing the V600E allele. Consistent with the high degree of selectivity, ERK phosphorylation is potently inhibited by PLX4720 in B-RafV600E-bearing tumor cell lines but not in cells lacking oncogenic B-Raf. In melanoma models, PLX4720 induces cell cycle arrest and apoptosis exclusively in B-RafV600E-positive cells. In B-RafV600E-dependent tumor xenograft models, orally dosed PLX4720 causes significant tumor growth delays, including tumor regressions, without evidence of toxicity. The work described here represents the entire discovery process, from initial identification through structural and biological studies in animal models to a promising therapeutic for testing in cancer patients bearing B-RafV600E-driven tumors.
15336878
Hot subdwarfs from the stable Roche lobe overflow channel
Context. Hot subdwarfs are core-helium-burning stars with extremely thin envelopes. We discuss the formation and evolution of hot subdwarfs formed through the stable Roche lobe overflow (RLOF) channel of intermediate-mass binaries, although their formation channels are various. Aims. In this study, we concentrate on the formation and evolution of hot subdwarfs binaries through the stable RLOF channel of intermediate-mass binaries. We aim at setting out the properties of hot subdwarfs and their progenitors, so that we can understand the formation and evolution of hot subdwarfs. Methods. Employing Eggleton's stellar evolution code, we have computed conservative and nonconservative population I binary evolution sequences. The initial mass of the primary ranges from 2.2 to 6.3 M(circle dot), spaced by approximately 0.1 in log M, the initial mass ratio q(i) = M(1)/M(2) is between 1.1 and 4.5, and the Roche lobe overflow begins at the main sequence, the Hertzsprung gap and the first giant branch. In nonconservative binary evolution, we assume that 50 percent of the mass lost from the primary leaves the system, carrying away the specific angular momentum of the primary, and the remaining mass is accreted on to the secondary during the RLOF. Also, we have studied the distributions of the mass and orbital periods of hot subdwarfs using the population synthesis approach. Results. We have obtained the ranges of the initial parameters of progenitor binaries and the properties of hot subdwarfs through the stable RLOF channel of intermediate-mass binaries, e. g. mass, envelope mass and age of hot subdwarfs. We have found that hot subdwarfs could be formed through stable Roche lobe overflow at the main sequence and Hertzsprung gap. We have also found that some subdwarf B or OB stars have anomalously high mass (similar to 1 M(circle dot)) with a thick envelope (similar to 0.07 M(circle dot)-similar to 0.16) in our models. By comparing our theoretical results with observations on the hot subdwarfs in open clusters, we suggest that more hot subdwarfs in binary systems might be found in open clusters in the future.
15702909
The continuum limit of perturbative coefficients calculated with a large field cutoff
Abstract We report MC calculations of perturbative coefficients for lattice scalar field theory in dimensions l, 2 and 3, where the large field contributions are cutoff. This produces converging (instead of asymptotic) perturbative series. We discuss the statistical errors and the lattice effects and sho-kv that accurate calculations are possible even in a crossover region where no approximation works. We show that the field cutoff is also a UV regulator. We point out the relevance for QCD questions discussed by Tomboulis ad Trottier at this conference.
55133202
Entanglement entropy in a holographic p-wave superconductor model
In a recent paper, arXiv:1309.4877, a holographic p-wave model has been proposed in an Einstein– Maxwell-complex vector field theory with a negative cosmological constant. The model exhibits rich phase structure depending on the mass and the charge of the vector field. We investigate the behavior of the entanglement entropy of dual field theory in this model. When the above two model parameters change, we observe the second order, first order and zeroth order phase transitions from the behavior of the entanglement entropy at some intermediate temperatures. These imply that the entanglement entropy can indicate not only the occurrence of the phase transition, but also the order of the phase transition. The entanglement entropy is indeed a good probe to phase transition. Furthermore, the “retrograde condensation” which is a sub-dominated phase is also reflected on the entanglement entropy. © 2015 The Authors. Published by Elsevier B.V. This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). Funded by SCOAP 3 .
14227222
Two-Dimensional Stellar Evolution Code Including Arbitrary Magnetic Fields. II. Precision Improvement and Inclusion of Turbulence and Rotation
In the second paper of this series we pursue two objectives. First, in order to make the code more sensitive to small effects, we remove many approximations made in Paper I. Second, we include turbulence and rotation in the two-dimensional framework. The stellar equilibrium is described by means of a set of five differential equations, with the introduction of a new dependent variable, namely the perturbation to the radial gravity, that is found when the nonradial effects are considered in the solution of the Poisson equation. Following the scheme of the first paper, we write the equations in such a way that the two-dimensional effects can be easily disentangled. The key concept introduced in this series is the equipotential surface. We use the underlying cause-effect relation to develop a recurrence relation to calculate the equipotential surface functions for uniform rotation, differential rotation, rotation-like toroidal magnetic fields, and turbulence. We also develop a more precise code to numerically solve the two-dimensional stellar structure and evolution equations based on the equipotential surface calculations. We have shown that with this formulation we can achieve the precision required by observations by appropriately selecting the convergence criterion. Several examples are presented to show that the method works well. Since we are interested in modeling the effects of a dynamo-type field on the detailed envelope structure and global properties of the Sun, the code has been optimized for short timescales phenomena (down to 1 yr). The time dependence of the code has so far been tested exclusively to address such problems.
15779981
Can Temperature Be Quantized
It is shown that the temperature may be quantized in some spacetime due to the periodically topological structure of the Euclidean section. The quanta of the temperature is the Hawking-Unruh temperature.
119184187
Holographic entanglement entropy in P-wave superconductor phase transition
A bstractWe investigate the behavior of entanglement entropy across the holographic p-wave superconductor phase transition in an Einstein-Yang-Mills theory with a negative cosmological constant. The holographic entanglement entropy is calculated for a strip geometry at AdS boundary. It is found that the entanglement entropy undergoes a dramatic change as we tune the ratio of the gravitational constant to the Yang-Mills coupling, and that the entanglement entropy does behave as the thermal entropy of the background black holes. That is, the entanglement entropy will show the feature of the second order or first order phase transition when the ratio is changed. It indicates that the entanglement entropy is a good probe to investigate the properties of the holographic phase transition.
54197110
A COMPREHENSIVE STUDY OF GAMMA-RAY BURST OPTICAL EMISSION. II. AFTERGLOW ONSET AND LATE RE-BRIGHTENING COMPONENTS
We continue our systematic statistical study of various components of gamma-ray burst (GRB) optical light curves. We decompose the early onset bump and the late re-brightening bump with empirical fits and analyze their statistical properties. Among the 146 GRBs that have well-sampled optical light curves, the onset and re-brightening bumps are observed in 38 and 26 GRBs, respectively. It is found that the typical rising and decaying slopes for both the onset and re-brightening bumps are similar to 1.5 and similar to-1.15, respectively. No early onset bumps in the X-ray band are detected to be associated with the optical onset bumps, while an X-ray re-brightening bump is detected for half of the re-brightening optical bumps. The peak luminosity is anti-correlated with the peak time L-p proportional to t(p)(-1.81 +/- 0.32) for the onset bumps and L-p proportional to t(p)(-0.83 +/- 0.17) for the re-brightening bumps. Both L-p and the isotropic energy release of the onset bumps are correlated with E-gamma,E- iso, whereas no similar correlation is found for the re-brightening bumps. These results suggest that the afterglow onset bumps are likely due to the deceleration of the GRB fireballs. Taking the onset bumps as probes for the properties of the fireballs and their ambient medium, we find that the typical power-law index of the relativistic electrons is 2.5 and the medium density profile behaves as n proportional to r(-1) within the framework of the synchrotron external shock models. With the medium density profile obtained from our analysis, we also confirm the correlation between the initial Lorentz factor (Gamma(0)) and E-iso,E-gamma in our previous work. The jet component that produces the re-brightening bump seems to be on-axis and independent of the prompt emission jet component. Its typical kinetic energy budget would be about one order of magnitude larger than the prompt emission component, but with a lower Gamma(0), typically several tens.