Remarkable Reaction Rate and Excellent Enantioselective Direct α‐Amination of Aldehydes with Azodicarboxylates Catalyzed by Pyrrolidinylcamphor‐Derived Organocatalysts
Remarkable reaction rate and excellent enantioselective direct α-amination of unmodified aldehydes with various azodicarboxylates was catalyzed by pyrrolidinylcamphor organo-catalyst 2a (5 mol-%) to provide the desired aminated products with excellent chemical yields and high to excellent levels of enantioselectivity (up to >99%ee) at 0 °C in CH 2 Cl 2 .