Phéromone synthésis-CXXXVII : A new synthesis of (+)-grandisol
The natural and (+)-enantiomer of grandisol [1, (1R,2S)-(+)-2-isopropenyl-1-methylcyclobutaneethanol] has been synthesized from (R)-(—)-carvone (2) by employing the intramolecular alkylation of 8 to give 9 as the key step.