SYNTHESIS OF 6b,11b-DIHYDROXY-12-METHYLPHENYL-11b,12-DIHYDROBENZO[ g ]INDENO[1,2- b ]INDOLE-5,6,7(6b H )-TRIONES AND 2-(3-HYDROXY-4,9-DIOXO-4,9-DIHYDRO-1 H -BENZO[ f ]INDOL-2-YL)BENZAMIDES, THEIR STRUCTURE AND ANTIPROLIFERATIVE ACTIVITY
Methods of synthesis of 6b,11b-dihydroxy-12-methylphenyl-11b,12-dihydrobenzo[g]indeno[1,2-b]indole-5,6,7(6bH)-triones and 2(3hydroxy-4,9-dioxo-4,9-dihydro-1H-benzo[f]indol-2-yl)benzamides are proposed. It was found that 6b,11b-dihydroxy-12-(3-methylphenyl)-11b,12-dihydrobenzo[g]indeno[1,2-b]indole-5,6,7(6bH)-trione exists as two stereoisomers. The antiproliferative activity of 6b,11b-dihydroxy-12-methylphenyl-11b,12-dihydrobenzo[g]indeno[1,2-b]indole-5,6,7(6bH)-triones and 2-(3-hydroxy-4,9-dioxo-4,9dihydro-1H-benzo[f]indol-2-yl)benzamides against human tumor and nontumor cells along with the features of their structures that are important for the manifestation of this activity has been established.