Heterocyclic derivatives of purines. 5. Nucleophilic substitution in series of imidazo[1,2-f]purine derivatives
The chlorination of 1,8-dimethyl-7-phenylimidazo[1,2-f]xanthine with an equimolar amount of PCl5 in POCl3 leads to 2,4-dichloro-8-methyl-7-phenylimidazo[1,2-f]-purine. The possibility of substitution of the halogen atoms in reactions with nucleophilic reagents to give various 4-amino and 2,4-diamino derivatives was studied.