Synthesis of 5(6)-decenoic acid
Use butyraldehyde and cyclohexanone as raw material via aldol condensation,hydrogenation,Beayer-Villiger oxidation and saponification dehydration reaction,to obtain the target product 5(6)-decenoic acid mixture(milk lactone).The factors influencing the yield of each step were analyzed,and the optimum conditions were obtained:(1)The aldol condensation:polyethylene glycol 400 as a phase transfer catalyst,n(butyraldehyde):n(cyclohexanone)=1:1.8,the temperature is 30 ℃;(2)The catalytic hydrogenation:hydrogen pressure is 2.5 MPa,temperature is 30 ℃;(3)The Baeyer-Villiger oxidation:n(2-butyl-cyclohexanone):n(urea peroxide)=1:1.8,temperature is 30 ℃;(4)The Saponification dehydration:alkali concentration of 30%(mass fraction),saponification temperature is 110 ℃.The total yield of reaction is 30.8%.