Effect of Hippophae rhamnoides L. on antioxidant system in the liver and brain of mice with acute alcohol administration
Objective: Exploration the effects of Hippophae rhamnoides L on antioxidant system in the liver and brain of mice with acute alcohol administration. Methods: Male ICR mice were divided randomLy into five groups, including control group, alcohol model group and 0.6, 3, 6 g/kg bw Hippophae rhamnoides L. groups. Continuous administration for 14 days, since fifteenth, the daily after administration of 1 h, alcohol model group and Hippophae rhamnoides L. in different dosage groups with 40% alcohol by intragastric 15 mL/kg bw, end to twentieth days. Measured the activity of GSH, MDA, CAT and T-AOC in the liver and brain tissues of mice. Results: Compared with alcohol model, Hippophae rhamnoides L. in different dosage groups in liver tissue GSH content increase, low dose group of increased the activity of CAT, in the high dose group, the increase of T-AOC activity; in the low and high dose group of brain tissue GSH content increased, in the middle dose and high dose group increased the activity of T-AOC. Conclusion: Hippophae rhamnoides L. on alcohol induced mouse liver and brain oxidative damage had obviousrelieving.