Correlation between Phototoxicity and Photoionization Efficiency of Phenothiazine Drugs
Irradiation of sodium hyaluronate (NaHA) in the presence of phenothiazine derivatives (PTZ) caused degradation of the biopolymer. It was found that measurement of the degradation efficiency was useful for estimation of the phototoxicity of the phenothiazine drugs. The results of laser photolysis suggested that the photoionization of PTZ is a key step in initiating degradation of NaHA.