Inhibition of regrowth of prostatic glandular cells by epristeride.
AIM
To evaluate the ability of epristeride to inhibit the prostatic glandular regrowth.


METHODS
Normal rats were castrated. Testosterone was injected to induce the regrowth of glandular cells. HE staining was performed. The height of the glandular epithelium and the acinar luminal areas were determined, and dihydrotestosterone (DHT) was detected by immunohistochemistry.


RESULTS
Both the height and the acinar luminal areas were reduced by 48 % and 55 % in epristeride-treated group compared with control group respectively. The staining of DHT was comparatively strong in the control group. After 30-d of treatment, it turned much weaker.


CONCLUSION
The regrowth of glandular cells was inhibited by epristeride via declining of the DHT concentration in the rat prostate.