CATALYTIC FUNCTION OF A HOST–GUEST COMPLEX DERIVED FROM OCTOPUS AZAPARACYCLOPHANE AND HYDROPHOBIC VITAMIN B12 AS A HOLOENZYME MODEL
The isomerization reaction accompanied with carbon-skeleton rearrangement, as typically catalyzed by the vitamin B12-dependent methylmalonyl-CoA mutase, was simulated by employing the host–guest complexes formed with an octopus azaparacyclophane having eight hydrocarbon chains and hydrophobic vitamin B12 derivatives.