Absorption of caffeine in rats after orally administered with Pu-erh tea
Comparative study of caffeine absorption in mice after oral administration of Pu'er tea, green tea and caffeine with three caffeine dose(5, 25 and 50 mg·kg-1·d-1) was conducted. The results showed that the plasma concentration of caffeine after feeding Pu'er tea was significantly less than that after oral administration green tea and caffeine at the doses of 25 mg·kg-1·d-1and 50 mg·kg-1·d-1. At the same time, the total absorption of caffeine was calculated by AUC(30-150 min)trapezoid formula. The total absorption of caffeine in plasma after administration of caffeine at the doses of 25 mg·kg-1·d-1and 50 mg·kg-1·d-1in the way of Pu'er tea was also significantly reduced after administration of caffeine at the doses of 25 mg·kg-1·d-1and 50 mg·kg-1·d-1in the way of green tea or caffeine(P0.05). Research results suggested that the absorption of caffeine in Pu'er tea was significantly decreased.