Continuous‐Flow Microreactor Chemistry under High‐Temperature/Pressure Conditions
High-temperature organic synthesis can be performed under continuous-flow conditions in a stainless steel microtubular flow reactor capable of achieving temperatures of 350 °C and 200 bar. Under these extreme experimental environments transformations normally performed in a high-boiling solvent at reflux temperature – or under sealed-vessel microwave conditions – can be readily converted to a flow regime by using lower boiling solvents in or near their supercritical state.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2009)