High-resolution mass spectrometry method for the analysis of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone in waters
A method was developed for the analysis of 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) in drinking waters that is based on electron-ionization high-resolution mass spectrometry and selected-ion monitoring of the m/z 199 and 201 ions of the methyl derivative of MX and the use of isotopically labeled benzoic acid as the internal standard. High-resolution mass spectrometry is needed to provide sensitivity, selectivity, and confidence in the identification of MX in water extracts. In the analysis of matrix spikes and replicate samples, the method provided recoveries of 102-108% and a precision of 8% RSD