Effects of 10-hydroxy-2-decenoic acid on phagocytosis and cytokines production of peritoneal macrophages in vitro.
AIM
To study the effect of 10-hydroxy-2-decenoic acid (HDA) on the macrophages activity of rats in vitro.


METHODS
To measure the effects of HDA on phagocytosis, the production of antitumor cytokines tumor necrosis factor (TNF) and interleukin-1 (IL-1) in vitro.


RESULTS
HDA 50, 100 mg.L-1 promoted phagocytic activity from 0.353 +/- 0.017 to 0.39 +/- 0.04 and 0.382 +/- 0.017 A, increased TNF and IL-1 production from 0.23 +/- 0.07% to 0.43 +/- 0.04%, 0.47 +/- 0.04% and from 2384 +/- 180 to 2943 +/- 295, 3825 +/- 450 dpm, respectively.


CONCLUSION
The upregulating effects of HDA on phagocytosis of PMO and production of TNF, IL-1 contribute to the host antitumor and immunomodulating mechanism.