Synthetic utility of endocyclic cleavage reaction
Abstract Existence of endocyclic cleavage reaction is now clearly shown from experimental evidence of endocyclic cleavage reaction as well as computational chemistry. Not only stereoelectronic factor, several factors could be main factors for endocyclic cleavage reaction. Endocyclic cleavage reaction is useful for 1,2-cis aminoglycoside formation, which is difficult by conventional glycosylation. By using endocyclic cleavage reaction, several glycosides with 1,2-cis aminoglycoside were prepared.