Study on the Directed Evolution of Interferon Family
This is the report of dir ected evolution of Human Interfero n Alpha Genes using DNA shuffling combined with phage display techno logy and cell-based competitive sc reening methods.The novel interfer on alpha hybrid with improved bioa ctivity was obtained and shows a g reat prospect in production.This s trategy also offers some informati on on the way of directed evolutio n of other cytokines or proteins.