SYNTHESIS AND ANTITUBERCULOTIC ACTIVITY OF SOME SUBSTITUTED 3-ARYLAMINO-5-CYANO-2-PYRAZINECARBOXAMIDES
Nucleophilic substitution of 3-chloro-5-cyano-2-pyrazinecarboxamide by substituted anilines afforded substituted 3-arylamino-5-cyano-2-pyrazinecarboxamides I-X . The structures of compounds were confirmed by elemental analysis, UV, IR and 1 H NMR spectra. The assessment of in vitro antimycotic and antimycobacterial activities of the compounds was carried out. The highest antituberculotic activity against M. tuberculosis in this series was shown by 3-anilino- 5-cyano-2-pyrazinecarboxamide ( I ), whose efficacy was the same as that of pyrazinecarboxamide.