P106 Role of Adenylate Cyclase Pathway in Prevention of Pulmonary Fibrosis
Our previous studies have shown that blocking Ca2+-signaling reduces TGFβ-mediated extracellular matrix (ECM) deposition and progression of bleomycin-mediated fibrosis. As such, disruption of Ca2+-wave activity may prove useful in the treatment of pulmonary fibrosis. Prostaglandin E2 (PGE2) is known to exhibit certain anti-fibrotic effects. However, its effect on …