SYNTHESIS AND REACTIONS OF 5-METHYLTHIENO[2',3':5,6]PYRIMIDO-[2,1-a]ISOINDOL-4(5H)-ONE
The reaction of 2-(bromomethyl)benzonitrile with methyl 3-aminothiophene-2-carboxylate results in two tautomeric thienopyrimidoisoindolones. Their methylation yields 5-methylthieno[2',3':5,6]pyrimido[2,1- a ]isoindol-4(5 H )-one which reacts with N-substituted maleimides and dimethyl acetylenedicarboxylate.