Reaction of Ethyl 5-Substituted-2-furoylmalonates with Secondary Amines
In situ prepared magnesium salts of ethyl malonate react with 5-X-2-furoyl chlorides (X = Br, NO 2 , C 6 H 5 S and C 6 H 5 SO 2 ) to give the corresponding ethyl 5-X-2-furoylmalonates. On treatment of these compounds with secondary amines no nucleophilic substitution of the group X in position 5 of the furan nucleus took place but, instead, amides of 5-X-2-furancarboxylic acids were isolated.