Simultaneous Determination of 22 Sulfonamides in Cosmetics by Ultra Performance Liquid Chromatography Tandem Mass Spectrometry
A comprehensive analytical method based on ultra-performance liquid chromatography tandem mass spectrometry has been developed for the simultaneous determination of 22 sulfonamides(sulfaguanidine,sulfanilamide,sulfadiazine,sulfisomidine,sulfacetamide,sulfathiazole,sulfapyridine,sulfamerazine,sulfameter,sulfamoxole,sulfamethazine,sulfamethizole,sulfamethoxypyridazine,succinylsulfathiazole,sulfachloropyridazine,sulfamethoxazole,sulfamonomethoxine,sulfadoxine,sulfisoxazole,sulfadimethoxine,sulfaquinoxaline and sulfanitran).Various cosmetic samples,including cream,lotion,powder,shampoo and lipstick,were extracted under ultrasonication.Qualitative and quantitative analysis was carried out for the analyte under the MRM mode after the chromatographic separation on Waters ACQUITY UPLC BEH C18(50 mm×2.1 mm,1.7 μm) column.The limits of detection for the 22 sulfonamides were 3.5-14.1 μg/kg.The mean recoveries at the three spiked levels were 80.3%-103.6%,with the intra-day precision less than 12% and the inter-day precision less than 15%.