Alkylation of 5-substituted 1-H-tetrazoles by Mannich bases under the action of ultrasound
Alkylation of 5-substituted 1-H-tetrazoles by Mannich bases — N-(3,5-dimethyl-4-hydroxybenzyl)piperidine and N-(2-hydroxy-3-methoxy-5-formylbenzyl)piperidine — under the action of ultrasound increases the yield of the desired products, reduces the reaction time, and improves the regioselectivity.