Study on delaying senility of spleen by lipoteichoic acid of Bifidobacterium bifidum
Objective To investigate the effect of lipoteichoic acid (LTA) of Bifidobacterium bifidum surface molecules on spleen index and DNA damage in spleen lymphocyte of aging mice induced by D-galactose. Methods Male Kunming mice were randomly divided into different groups. These mice were treated by subcutaneous injection of D-galactose on the back for aging induction and LTA was simultaneously administered for 40 days. Single cell gel electrophoresis was used for testing DNA oxidative damage. Results There were significant differences for spleen index,the appearance rate of comet and the length grade of DNA between the young control group and the aging model group(P0.05). In the mice treated by LTA,the changes were significantly inhibited as compared with the aging model group(P0.05). Conclusion LTA can decrease spleen index,restrict DNA damage of spleen lymphocyte,and so it may be a molecular mechanism to explain Bifidobacterium delaying senility.