Application and progress of dynamic kinetic resolution (DKR) technology in asymmetric catalysis
Catalytic asymmetric synthesis is an important field in organic chemistry. The disadvantage of the traditional kinetic resolution is that the maximum yield is only 50%. But by using dynamic kinetic resolution (DKR) technology, the racemic starting materials can be transformed to one enantiomer totally and the yield can reaches 100%. The enzymatic kinetic resolution, metal-catalyzed racemization,and the principle and application of DKR technology that combines enzymes and metal catalysts are described.