Mediastinal nodular AL-amyloidosis with progressive calcification.
Mediastinal localised light chain amyloidosis (AL)-amyloidosis remains a rare disease. Radiological manifestations are non-specific but calcification is seen with high frequency. Histological examination with characterization of amyloid deposit is required for definitive diagnosis.

Therefore, mediastinal AL-amyloidosis should be considered in the differential diagnosis of a large mediastinal mass, especially if calcifications are present.

Amyloidosis is a rare disease, characterized by deposits of insoluble proteins. In AL, the monoclonal free immunoglobulin light chains constitute the protein precursor of the deposit. AL amyloidosis is usually systemic and rarely localized. We report a case of mediastinal AL-amyloidosis, also called amyloidoma, with serial computerized tomography (CT)-scan showing a slowly progressive increase of the mass with diffuse calcifications over a 4-year period.

A 66-year-old man, a past smoker, with medical history of hypertension, coronary arterial disease and dyslipidemia consulted in 2011 for …