The role of NF-κB on cytokines secretion in pathogenesis of psoriasis
Objective To study the controlling mechanism of NF-κB in the pathogenesis of psoriasis. Methods Establish by mix-cultured T cells from psoriasis patients and keratinocytes, then cytokines were detected by semiquantitative RT-PCR and NF-κB activity was analyzed by EMSA. Results Compared with control group, the expression of cytokines increased with an enhanced NF-κB activity. TPCK and tripterygium glycosides treatment could inhibited cytokines secretion and NF-κB activation. Conclusion NF-κB activation is important in the inflammatory reaction of psoriasis, suggesting that inhibition of NF-κB activation may improve clinical pictures of psoriasis. [