Dose- and Exposure-Response to Ketamine in Depression
To the Editor: W e read with interest the recent report on the repeateddose use of ketamine as a rapidly acting antidepressant in patients with treatment-resistant depression (1). Despite the promising antidepressant responses to this intervention in this and other studies (2– 4), several important technical questions about administration of ketamine have not yet been explored (5). These include route of administration, dose– exposure relationship, and exposure– and dose–response information. In this letter, we present a simulation on projected exposures between intramuscular and intravenous (IV) ketamine to establish comparable doses and report preliminary dose–response data in patients with treatment-refractory bipolar II depression.