Uremic malnutrition-inflammation syndrome in chronic renal disease: a pathobiologic entity.
HRONIC UREMIA is an inflammatory condition that is characterized by a persistent metabolic derangement, nutritional and hormonal dysfunctions, oxidative imbalance, and immune dysregulation. There is a close association between malnutrition and inflammation in chronic renal disease (CRD), both of which are strong predictors of poor outcome. Thus, although protein energy malnutrition may be evident in about 45% of renal patients at initiation of dialysis, protracted nutritional deficiency and inflammatory-oxidative stress closely correlate with