Aromatase inhibitor of formestane and letrozole on sexual differentiation of muscovy
The differentiation of poultry′s gonads is related to the regulation of estrogen,and the synthesis of estrogen is catalyzed by aromatase.The female muscovy gonads can develop into male when the activity of aromatase is blocked by aromatase inhibitor before sexual differentiation.In order to learn the effection of aromatase inhibitor to the hatchability and the growth of sexual gonade on muscovy,in this experiment,the fertilized eggs were injected separately with two kinds of aromatase inhibitors,formestane(steroid) and letrozole(nonseroid).The results showed that 100 and 150 μg·egg-1 formestane(steroid) can effectively reverse female muscovy to male(P0.01),the rate of masculinization was 52.94% and 55.56% which was identified by genetic sex,but the hatchability of muscovy decreased along with the concentration of formestane,100 μg·egg-1 letrozole(nonseroid) can effectively reverse female muscovy to male(P0.05) and the rate of masculinization was 36.36%,but 50 and 150 μg·egg-1 letrozole can′t reverse sexual efficiency.The hatchability of letrozole groups were lower than that of the normal group.The two sides of sexual gonads on fully masculinized muscovys were like normal testis,but there were some morphologic differentiations among the two sides of sexual gonads on partial masculinized muscovys.The left gonad was reversed less than the right′s and the structure was between testis and ovary.