Effect of the Gardenia extracts T9 on VP16 mRNA in herpes simplex virus type-1 infected mice's brains
Objective To investigate the effect of the Gardenia extracts T9 on herpes simplex vires （HSV） viral protein 16（VP16） in HSV-1 infected mice＇s brains and its potential anti-viral mechanism. Methods HSV-1 infection was induced in BALB/c mice, the expression of HSV VP16 was detected by RTPCR on the 4th, 7th, 10th, 14th, and 21st day. Results The expression of VP16 mRNA decreased in both groups of large and low doses compared with virus group at the same time. Conclusion Gardenia extracts T9 can down-regulate the expression of VP16 mRNA in HSV infected mice＇s brains, and it may be one of its anti-HSV mechanisms. 
 
Key words: 
Gardenia extracts T9;  Herpes simplex virus type-1 ;  Viral protein 16