[Pharmacodynamics of 5-(1,3,3-trimethylindolinyl)N,N-dimethyl carbamate in mice].
5-(1,3,3-Trimethylindolinyl) N, N-dimethyl carbamate (TMDMC) is a strong cholinesterase inhibitor. The concentration (C) in blood of mice was measured after ip TMDMC 1.5 mg/kg and the % inhibition of blood and brain cholinesterases were calculated by following equations: 
Ln[Eblood/(100-Eblood)]=3.58+/-0.9941 ln Cblood 
Ln[Ebrain/(100-Ebrain)]=1.91+/-ln Cblood 
The inhibition of brain cholinesterase was estimated by the following equation from the degree of blood cholinesterase inhibited. 
ln Ebrain=3.67 Eblood+3.69 
Measuring the extent of miosis (M) of mice following in TMDMC 1.0, 0.5, 0.25 mg/kg the blood concentration (C) was calculated by the equation: 
Ln (M/(100-M))=3.65+1.006 ln C