Epstein-Barr virus and lymphoproliferative disorders: Basic concepts and diagnostic approach
Abstract With an increasing number of immunosuppressed and HIV-infected patients, it is expected that EBV-related lymphoproliferative disorders will be more common than in the past. Experimental and clinical studies are providing important information about the role of EBV in these disorders and in the process of oncogenesis. The availability of new sensitive diagnostic tools, such as PCR, can improve our ability to establish a viral diagnosis and to delineate the full spectrum of EBV disease in this patient population. However, these new tests will require extensive clinical evaluation to establish their exact role in diagnosis and disease monitoring.