The Direction of Ring Fission of Unsymmetrically-substituted Succinic Anhydrides. 1. Interaction of α-Tetrahydrofurylsuccinic Anhydride with Benzylamine and 2,5-Xylidine
The reaction of α-tetrahydrofurylsuccinic anhydride with amines proceeds regiospecifically at room temperature with the formation of N-substituted 2-(α-tetrahydrofuryl)succinamic acids. On increasing the temperature the reaction direction is changed and the 3 isomer is mainly formed.