Synthetic Studies toward Actinorhodin and γ‐Actinorhodin by using a Homo‐coupling Strategy: Synthesis of Hemiactinorhodin and Hemi‐γ‐actinorhodin
A homo-coupling strategy toward the synthesis of actinorhodin and γ-actinorhodin has been explored. The monomeric unit was synthesized by employing an efficient combination of Dotz benzannulation and oxa-Pictet–Spengler reactions. Attempts towards oxidative homo-coupling of the pyranonaphthalene monomer intermediate to give dimer were unsuccessful. Later, monomer pyranonaphthalene was carried forward to complete the synthesis of hemiactinorhodin and hemi-γ-actinorhodin.