Determination of New Type of 4 Bactericids Used for Control of Oomycete Diseases Residues in Fruits and Vegetables by Liquid Chromatography/Tandem Mass Spectrometry
A method was developed for the determination of ethaboxam,benthivalicarb-isopropyl,fluopicolide and mandipropamid in fruits and vegetables.The analytes were extracted from the samples by acetonitrile,and purified by dispersion solid phase extraction using ODS C18-N and PSA as solidphase,and then analyzed by LC/MS/MS with multiple reaction monitoring(MRM).The interference of matrix was reduced by the matrix-matched calibration standards curve.The linear range was from 1 μ /L to 100 μ /L for ethaboxam,fluopicolide,from 0.5 μ/L to 50 μ g/L for benthivalicarb-isopropyl,mandipropamid(r≥0.9994).The fortified recoveries were from 80.9% to 101.3% with relative standard deviations(RSD) lass than 6.3%.The limits of quantification were 0.53 μ g/kg to 1.3 μ g/kg and the limit of detection were 0.16 to 0.40 μ g/kg.