Pathogenicity and immunogenicity of rabies virus strain 3aG-V adapted to vero cell line
A rabies virus strain 3aG-V adapted to Vero cell line had been characterised in pathogenicity and immunogenicity as wellPathogenicity of the virus strain was observed in mice,rabbits,Guinea pigs and caninies infected with this virus through different routesImmunogenicity in mice,rabbits,Guinea pigs had also been investigated by determining the protection indexMeanwhile,the virus strain was identified by rabies virus neutralizing antibody and the Negri body formation in mice central nervous system was observedBy comparing with rabies virus 3aG-5 strain,the 3aG-V possessed weak pathogenicity,longer incubation period, inclusion bodies forming in neurocells,and good immunogenicity in laboratory animalsThe 3aG-V was proven to be a fixed rabies virusThe results suggested that this strain can be used in preparation of purified Vero cell rabies vaccine in our country