A Metabonomics Study on Heroin Addicts Using Liquid Chromatography Coupled with Ion Trap-Time of Flight Mass Spectrometry
To screen the possible biomarkers of heroin addicts,we used metabonoics method to detect serums and urine of those people.The samples of 16 heroin addicts and 16 healthy controls were analyzed by LC/MSIT-TOF in the metabonomics study.24 potential biomarkers in the serums and urine( 12 each) were identified from these participants by using multivariate statistical analysis.It was found that these two groups of people had existed-significant differences on their serums and urine metabolic levels.Our analyses of these metabolites provided evidence on heroin addicts could be differentiated from healthy individuals with potential biomarkers.24 potential biomarkers in the serums and urine( 12 each) were identified from these participants by using multivariate statistical analysis.It was found that these two groups had existed-significant differences on their serums and urine metabolic levels.These metabolites could be used as an evidence on heroin addicts and the potential biomarkers differing from healthy individuals.