Analysis of B/C Recombinant Structure of C Gene in A Newly Found HBV Subtype
Hepatitis B is one of the most serious global threats to human health.Phylogenetic analysis of hepatitis B virus(HBV)can reveal the evolutionary relationship between HBV sequences and thus provide a basis for the prediction and treatment of hepatitis B and other aspects.In this study,we performed sequence analyses on the HBV sequences of five clinical HBV samples and the HBV sequences retrieved from the GenBank,EMBL,and DDBJ to construct a phylogenetic tree and analyze sequence structures.The experimental results revealed that the C gene of one cloned sequence had a recombinant structure of HBV B/ C subtype.Moreover,the phylogenetic results proved the existence of a newly found subtype HBV/B6in Xishuangbanna of Yunnan Province,China.The experimental conclusion represents certain value for phylogenetic studies of HBV in Yunnan ethnic minority groups.