Mixture experiments with process variables: D-optimal orthogonal experimental designs
Blending experiments with mixture in the presence of process variables are considered. We present an experimental design for quadratic (or linear) blending. The design in two orthogonal blocks is D-optimized in the case where there are no restrictions on the blending in two orthogonal blocks is presented when there are arbitrary restrictions on the blending components. The pair of orthogonal blocks can be used with and arbitrary number of process variables. The number of design points needed when different orthogonal blocks are used is usually smaller than when a single block is repeated at the various process variables levels.