Research of association between type 1 diabetes and HLA-DR, DQ molecules in northern area in China
Objective To study the association between insulin dependent diabetes mellitus (IDDM) and HLA DR, DQ molecules. Methods Fifty three IDDM cases and 185 controls in northern China were HLA class Ⅱ DNA typed for DRB1, DQA1 and DQB1 analysis. Results DRB1*0301/DRB1*04 heterozygous was in the highest risk with the RR value of 51.13. By making the DQ analysis of Arg in the position 52 of DQ α chain as a susceptible factor (named as S, the opposite is P) and the non Asp in position 57 of DQ β chain as an another susceptible factor (S and P). The highest risk was found when an individual has the factor combination S≥3 (RR=29 89), and the protective factors were appeared when P≥2. However, the factors from DR molecule still could not be ignored since the RR value of DR3/DR4 heterozygous was 51.13. Conclusions The DR3/4 heterozygous can be the first marker for forecasting the IDDM susceptibility, and the 3S factor can be the second way for IDDM forecasting and prevention. In addition to DQ molecules, the susceptible factors from DR alleles could be further clarified by DR4 subtyping.