Nanopore Analytical Chemistry
There is a plenty of biological nano-scale devices in nature,such as ion channels and protein pores,which inspired people to design and fabricate biomimetic systems(solid-state,hybrid nanopores and nano-channels) for analytical and sensing applications.Nanopore Analytical Chemistry designed based on these nano-devices are important for biosensors,nanofluidic devices,molecular filtration,synthetic biology,detection of single molecules and DNA sequence.In this paper,the history,classification,fundamental,applications and respects of nanopore analytical chemistry,especially recent advances of nanopore applications in DNA sequence and detection of proteins have been reviewed.