260 : Association of polymorphic variation of MCP-1 (-2518 A/G) SNP with clinical symptoms in systemic lupus erythematosus patients from western India
Systemic Lupus Erythematosus (SLE) is a clinically heterogeneous chronic, inflammatory autoimmune disorder that affects multiple organs. The exact etiology of the disease is not clearly understood. Various polymorphisms in genes of inflammatory mediators influence development of the disease. In this study, we have tried to see the association of Monocyte Chemoattractant Protein-1 ( MCP-1) − 2518 A/G Single Nucleotide Polymorphism (SNP) with clinical symptoms in Indian SLE cohort. The case control study conducted on 173 clinically diagnosed Indian SLE patients and 163 ethnically matched healthy controls. The disease severity was categorised into mild, moderate and severe based on SLEDAI score. The SLEDAI score varied from 3 to 41. Genotyping of MCP-1 ( − 2518 A/G) polymorphism was performed using a (PCR-RFLP) method. Arthritis and Malar rash were the clinical manifestations predominantly seen among our SLE patients. We did not report a statistically significant difference ( p  > 0.05) in the distribution of MCP-1 −2518 A/G polymorphic variants among SLE patients (29.77%) as compared to healthy individuals (36.8%). When we tried to evaluate its effect on clinical manifestations, we found statistically significant association of MCP-1 (−2518A/G) polymorphisms with the renal disorder ( p p MCP-1 −2518 (G/G and A/G with A/A) genotypes ( p  = 0.0126) and G/G with A/A ( p  = 0.0091) genotypes was noted in patients with Serositis. These results suggest that G allele of MCP-1 (−2518 A/G) polymorphism might be contributing in the diseases severity among Indian SLE patients.