Synthesis of Optically Pure 4-Hydroxymethyloxazolidinone as Chiral Serinol Synthon from Glycidol
Optically pure 3-benzyl-4-hydroxymethyl-2-oxazolidinone and 4-benzoyloxymethyl-2-oxazolidinone as chiral serinol synthons were synthesized from optically active glycidol by intramolecular cyclization via 2,3-epoxycarbamates with strict SN2 behavior.