A MATHEMATICAL MODEL OF RAT VENTRICULAR CARDIOMYOCYTE WITH ANOVEL DESCRIPTION OF INTRACELLULAR AND T-TUBULAR Ca2+ DYNAMICS
In this paper, we present a novel quantitative description of
intracellular and t-tubular Ca2+ dynamics in a model of rat
cardiac ventricular myocyte. In order to simulate recently
published data, the model incorporates t-tubular and peripheral
dyads and intracellular subspaces, segmentation of the
t-tubular luminal volume, reformulation of the inactivation
properties of t-tubular and peripheral L-type calcium current
(ICa) and a description of exogenous Ca2+ buffer function in
the intracellular space. The model is used to explore
activity-induced changes of ion concentrations in the
intracellular and t-tubular spaces and their role in excitation
– contraction coupling in ventricular myocytes.