Effects of lactoferrin and lactoferricin on lymphocyte proliferation
Lactoferrin and its peptide were reported have many biological activities. Lactoferrin and its peptide from different sources showed great differences in many activities. The purpose of this study was to examine and compare the effects of four kinds of lactoferrin(native human, camel, bovine and sheep) and pepsin hydrolysates on the proliferation of mouse spleen lymphocytes, and provide scientific basis for the development and application of lactoferrin and its peptide. The experimental results showed that four kinds of lactoferrin all had inhibition effect of proliferation of spleen lymphocyte induced by Con A. The inhibitory effect of camel lactoferrin was strongest. While four lactoferrin polypeptides played a promoting role in certain concentration range on spleen lymphocyte proliferation induced by Con A, otherwise the opposite. The effect of four lactoferrin polypeptides on spleen lymphocyte proliferation induced by Con A had no significant difference between group comparison.