Versatile Synthesis of 1‐O‐(ω‐Aminolauryl)‐I(4,5)P2
The synthesis of a model 1-O-(ω-aminoacyl)-IP2 derivative, lauryl 4,5-bisphosphate 31, was realized following a versatile and high-yielding scheme. The flexible synthetic strategy used for this purpose allows the preparation of a range of other useful IP, IP2 and IP3 derivatives. In view of the central role played by IPs and PIPs in cellular life, the preparation of functionalized myo-inositol derivatives of this type may facilitate the isolation and fluorescent localization of related proteins.