Synthesis and Characterization of Dual-function H2O2-Responsive Nanoparticles for Drug Delivery to Treat Atherosclerosis
Abstract Oxidative stress is one of the major factors involved in pathogenesis of atherosclerosis. Here, a smart dual-function drug delivery system (DDS) that neutralized the plaques through its reaction with the oxidative microenvironment was fabricated. Micelles were obtained from the graft copolymer of serotonin hydrochloride, polyethylene glycol, p (itaconic acid) and aminophenylboronic-acid-linked rutin. Fluorescence carbon quantum dots (CDs) were attached to the surface of the micelles to provide dual functionality of precise treatment and diagnosis. DDS was simultaneously served as a stimuli-responsive drug delivery carrier and as a probe to detect plaques. In vitro experiments indicated that these “smart” nanoparticles could efficiently target macrophages and provide accurate imaging. At the same time, their “smart” responses to H2O2 solved the problem of sudden drug release, which could significantly improve therapeutic effect of the delivered drug.