Study on the association between the clinical manifestation of SLE and the HLA haplotypes
Objective To explore the association between the clinical manifestation of systemic lupus erythematosus (SLE) and the HLA haplotypes. Method The HLA DR and DQ alleles were typed by the PCR SSOPH among 113 cases of diagnosed patients with SLE and the their HLA haplotypes were analyzed. Results The haplotype of DQA1*0501 DQB1*0301 was negatively associated with proteinuria ( P c0.05), and DQA1*0301 DQB1*0302 positively associated with increased serum creatinine ( P c0.05), DQA1*0201 DQB1*0201 was positively with leukocytopenia ( P c0.05). The haplotype of DRB1*1501 DQA1*0103 DQB1*0303 was positively associated with uria cast ( P c0.001), and so were DRB1*1501 DQA1*0301 DQB1*0601 with neuropsychiatric manifestation ( P c0.01) and DRB1*1501 DQA1*0102 DQB1*0303 with uria cast ( P c0.01). DRB3*0202 DQA1*0501 DQB1*0301 was negatively associated with proteinuria ( P c0.05). Conclusion The SLE patients possessed special haplotypes which might be more important factors than single genes to affect the expression of SLE subtypes.