Analysis of antimicrobial resistance of clinical isolates of enterococci from Nantong and other areas in Jiangsu Province
Objective :To analyze the antimicrobial resistance phenotype of entericocci to provide impersonal information. Methods : Disk diffusion method according to CLIS was used to test the antimicrobial resistance of 2936 enterococcal isolates from 4 comprehensive hospitals in Nantong and 10 grade 3 hospitals in other areas of China from years 2003 to 2006. The laboratory data was analyzed by WHONET5 statistic software. Results: Enterococcus. Faecalis isolates and E. faecium isolates accounted for 80.4% and15.1% of the entericoccus isolates in Nantong and 78.1% and 16.2% in other areas, respectively. The entericoccus isolates from urine, sputum, secretion with pus, blood, and bile accounted for top five 33.7%,22.9%,9.8%, 4.4%, and 3.0% of the entericoccus isolates in Nantong and 28.4%,16.3%,14.6%,S.0%, and 4.5% in other areas respectively. The resistance rates of E. faecalis to vancomycin, teicoplanin ampicillin, and high-level gentamicin were 2.0%v 1.4%, 17.0%, and 47.3% in Nantong , and 5.1%,3.7%,24%, and 49.2% in other areas; The resistance rates of E. faecalis to vancomycin, teicoplanin, ampicillin, and high-level gentamicin were 1.4%,2.7%,64.2%, and 64.9% in Nantong and 2.2%,3.1%,67.9%, and 62.3% in other areas respectively. The vancomycin-resistant rate of the total isolates of entericocci was 3.5%. Conclusions : Enterococcus faecium is the main species in the entericoccus isolates from clinical samples. E. faecium, compared with E. faecalis, resists many antimicrobial agents more strongly. Both of E. faecalis and E. faecium show the least resistance to vancomycin and teicoplanin.