Selective Glycosylation with the Amino Sugar D‐Forosamine for the Synthesis of Spinosyns and Its Analogues
For the synthesis of novel spinosyn analogues, the selective introduction of the 2-deoxyamino sugar, D-forosamine, necessary for their bioactivity, is described. The reactions of different alcohol acceptors with the D-forosamine donor in the presence of iodine and Et3SiH gave the corresponding glycosides in yields of up to 96 % and with an α/β selectivity of 2:3.