Study of Cyclophilin-A, High Sensitivity C-reactive Protein, and Malondialdehyde in Obese and Nonobese Type 2 Diabetes Mellitus Patients
Aim and objectives: To study cyclophilin-A, high sensitivity C-reactive protein (hsCRP) and malondialdehyde in obese and nonobese type 2 diabetes mellitus (DM) patients. Material and methods: A total of 120 subjects aged 35–65 years were enrolled and grouped as: • Obese subjects with diabetes, • Nonobese subjects with diabetes, • Obese subjects without diabetes, • Nonobese subjects without diabetes. Their serum was tested for estimation of 4 biochemical parameters, namely cyclophilin-A, hsCRP, malondialdehyde, and lipid profile. Observation and results: The mean cholesterol, triglycerides (TG), VLDL, LDL levels were significantly higher in obese diabetics as compared to obese nondiabetics, normal body mass index (BMI) diabetics, and control group. The mean HDL was higher in nondiabetic obese as compared to obese diabetic patients, normal BMI diabetics and control group and this difference was statistically insignificant. Cyclophilin-A and hsCRP were significantly higher in obese diabetics as compared to non-diabetic obese patients, Normal BMI diabetics and control group. The mean lipid peroxide (malondialdehyde) was significantly higher in nondiabetic obese patients, as compared to obese diabetics, normal BMI diabetics, and control group. Conclusion: Cyclophillin-A (CypA) and hsCRP were significantly elevated in obese type 2 diabetics while malondialdehyde was significantly higher in nondiabetic Obese patients. Lipid profile parameters were also significantly elevated in obese type 2 diabetics. These inflammatory cardiometabolic risk biomarkers can be used for diagnostic, therapeutic and prognostic decisionmaking, especially in the context of inadequate quantitative risk assessments available to clinicians.