[Effects of oxyfedrine on blood rheology in rabbits].
The effects of oxyfedrine (OF) on blood viscosity (BV), hematocrit (HCT), plasma viscosity (PV), and erythrocyte electrophoretic mobility (EEM) were studied in rabbits. OF (0.12 mg/kg iv) decreased BV. (At shear rate of 70 s-l, peak value 1.01+0.44 mN.s/m2. P<O.O1: at shear rate of 700 s-l, peak value 0.35+0.13 mN.s/m2, P<0.05. HCT (peak value 2.04+1.66%, P<O.01) and PV (peak value 0.14 +0.13 mN.s/m2, P<0.05), and increased EEM (peak value 0.12+0.12 (vm .s-l)/(V.cm-l), P<0.05). These actions lasted about 100 min. There were no significant differences in the reduction of BV among 4 groups (iv OF 0.12, 0.24, 0.49, 1.00 mg/kg,respectively). These data suggest that OF decreases BV may be related to the decreasing of HCT and PV, and increasing of EEM by OF. It provides an explanation for the anti-anginal action of OF.