Synthesis and antimicrobial activity of Sucrose Methyl Fumarate
Selecting and preparing solid superacid SO2-4/TiO2 as catalyst, the sucrose methyl fumarate(SMF), a new type of preservatives and mold preventives, was synthesized. The process of synthesizing SMF includes three reactions: mono-Sucrose maleate(MSM) first obtained by esterification of maleic anhydride and sucrose; the formation of SMF by isomerization of MSM and then reaction with methanol. An optimizing "one pot" technology by single factors method was obtained. Some antimicrobial characters of sucrose methyl fumarate(SMF) of 5.5 degree of esterification(DE), such as minimum inhibition concentration(MIC), growth curves, adaptive phase, and so on, were studied and compared with sorbic acid and di-methyl fumarate(DMF). The result showed that SMF had broad-spectrum inhibition activity to bacteria, yeast and mold. The adaptive phase of Escherichia coli and Bacillus thuringensis was expanded 10 and 12 times of blank when 0.12% SMF was added. The adaptive phase of Bacillus thuringensis was extended 6 times of blank, Aspergillus niger began grow after 96h, and the blank started grow after 20h, when 0.10%, 0.06% SMF was added, respectively. The anti-microbial activity of SMF was higher than sorbic acid and close to DMF.