The role of exercising in improving the myocardial fibrosis of diabetic rats and its possible mechanism
The authors established a type 2 diabetic rat model by means of high fat feeding plus intraperitoneal injection of a small dose of streptozotocin(STZ),probed into the role of exercising in improving the myocardial fibrosis of type 2 diabetic rats,and revealed the following findings: as compared with those of the rats in the normal control group,the blood GLU,GHb,GSP and INS level as well as myocardium AGEs,Hyp,CVF,GSSG/GSH,MDA and NF-κB P65 protein expression of the rats in the diabetic control group increased significantly(P0.05 or P0.01);as compared with those of the rats in the diabetic control group,the blood GLU,GHb and GSP level as well as myocardium AGEs,Hyp,CVF,GSSG/GSH,MDA and NF-κB P65 protein expression of the rats in the diabetic exercising group decreased significantly(P0.05 or P0.01).The said findings indicated the followings: the type 2 diabetic rat model duplicated by this experiment showed such a sign as myocardial fibrosis;exercising could improve the fasting blood glucose of type 2 diabetic rats,lower myocardial tissue’s AGEs content,oxidative stress and the level of NF-κB P65 protein expression,play a role in improving the myocardial fibrosis of type 2 diabetic rats;AGEs or oxidative stress or NF-κB P65 might be an important channel for exercising to improve the myocardial fibrosis of type 2 diabetic rats.