Enantioselective terpene synthesis based on R-(+)-limonene
The prevalence of a C - common core in diverse C terpenes has been recognised. A bifun%onal C I 2-cyclopentanoid deriva%:% corresponding to this common-core has been prepared from R-(+)-limonene. The enantiomerically pure 2 has b een e laborated to several sesqui- and diterpene skeleta. In particular, enantioselective syntheses of isodaucane sesquiterpene, (+)-aphanamol-I, 3 and a dolabellane diterpene, 6-araneosene 26 have b een a ccomplished for the first time. A general solution to the stereochemical problem associated w ith t his c lass of compounds has been devised. Syntheses of (-)daucene 8 and (+)-isoamijiol 17 are also described.