Studies of potential linkage between HLA class I alleles and HIV infection
Objective To investigate the association of HIV infection with frequencies of HLA class A, B, C alleles, and to analyze the correlation of HLA with susceptibility of HIV infection and with disease progression. Methods HLA class Ⅰ alleles was performed by Micro SSP TM , twenty-nine patients with HIV were detected. Results Analysis of the frequencies of specific at the A, B, and C loci revealed a significantly higher frequency of B35 alleles among HIV infectious patients comparing with controls (B35: P c0.05, RR=5.83). Conclusion HLA-B35 alleles were significantly higher than that in control group, HLA-B35 alleles are potentially associated with susceptible HIV infection. [