Effects of Polygonatum polysaccharides on antioxidation and neurotransmitter in exercise fatigue rats
Objective: Effects of Polygonatum polysaccharide on anti-oxidation and central neurotransmitters in exercise training rats were investigated. Methods: 50 rats were randomly divided into quiet group, exercise group, Polygonatum polysaccharide in small, moderate and hige dose group. A rat model of long-term loaded training was established in all the other groups except the quiet group. Polygonatum polysaccharide was give 0.3, 0.6, 1.2 g/kg respectively in Polygonatum polysaccharide groups while equal dose of saline was given in the quiet group and exercise group. Blood and tissue specimens were immediately collected after the last training. Serum superoxide dismutase(SOD) and malondialdehyde(MDA), serotonin(5-HT) and dopamine(DA) in the brain were determined. Results: Polygonatum polysaccharide can significantly improve the SOD activity and decrease the MDA content in serum, and decrease the production of 5-HT and increase DA content in the brain of exercise fatigue rats, thereby delaying the occurenct of fatigue. Conclusion: Polygonatum polysaccharide can inhibit the lipid peroxidation, adjust the contents of 5-HT and DA in the brain, and play a role in delaying exercise-induced peripheral fatige and central fatigue.