The Hypoglycemic Pharmacodynamic and Clinical Study by Berberine
Objective To do some research for the hypoglycemic action of the traditional Chinese medicine berberine.Methods To set up the diabetic mice model with alloxan,then to treat the mice with various dosages of berberine and phenformin as control.The blood glucose Level and glucose tolerance were tested with the glucoseoxidase method and the serous insulin level was measured with radioimmunoassay method.To randomly divide 73 cases of patients who had NIDDM into the Berberine group and the control,Diamicron group,then make the clinical comparison and observation.Results Berberine showed hypoglycemic action for diabetic mice.It could improve the glucose tolerance and increase the serous level of insulin,which showed centain dose-effect relationship.The effective rate of 43 cases of NIDDM treated with Berberine were 81.39%,For 30 cases of the control group,the effective rate were 80.00%.Both groups showed obvious treatment effects without conspicuous difference(both P0.05).Conclusion Berberine has hypoglycemic function for diabetic mice and NIDDM.