Effect of red cell transfusions, thymic hormone and deoxycytidine in severe combined immunodeficiency due to adenosine deaminase deficiency.
A child with severe combined immunodeficiency due to adenosine deaminase deficiency was treated with thymic hormone (TP1) alone, thymic hormone with red cell transfusions and finally with a combination of these and parenteral deoxycytidine. TP1 alone produced no benefit while the addition of red cell transfusions resulted in only partial immunological restoration despite improvement in clinical and biochemical findings. Deoxycytidine given subcutaneously produced no additional benefit in any of the parameters measured.