Development of an alanine-derived chiral stabilized azomethine ylid based on the 5-(2′-naphthyl)morpholin-2-one template
A rows to enantiomerically pure α-methyl functionalized proline derivatives is presented, using a 1,3-dipolar cycloaddition strategy based upon a homochiral 5-(2′-naphthyl)morpholin-2-one template. A mild means of generating stabilized azomethine ylids using sonication and Lewis acid catalysis is developed, avoiding the use of excessive temperatures.