Cross neutralization reaction of SARS virus BJ01 and GZ01 strains with sera of SARS patients from Beijing and Guangzhou regions
Objective To study the immunogenic relationship between SARS virus BJ01 and GZ01 strains, for selecting vaccine candidate virus strain. Methods Using Reed-Muench method to test the titers of SARS virus BJ01 and GZ01 strains. 6 sera from SARS patients of Beijing and Guangzhou were separately selected and cross-neutralization test was conferred to investigate their neutralization antibody titer and ability of cross neutralization. Results ① The sera of Beijing and Guangzhou patients could neutralize local isolated SARS virus. ② The sera of Beijing and Guangzhou patients could cross-neutralize both BJ01 and GZ01 strains. ③ Their neutralization antibody titers were almost the same with both virus strain. Conclusion The SARS virus BJ01 and GZ01 strains showed no distinct difference in terms of neutralization antibody reactivity.