Synthesis and biological activity of carbocyclic substituted N‐alkylmorpholines
Abstract Synthetic approaches to the preparation of new carbocyclic substituted N‐alkylmorpholines are reported. R = phenyl, substituted phenyl, cyclohexyl, substituted cyclohexyl, bicyclo [2.2.1 ]heptyl (2), or 2,2‐dimethyl‐bicyclo [2.2.1] heptyl (3); R1,R2 = H, CH3; n = 0 ‐ 2 The derivatives were obtained by the following methods: ‐ Reaction of appropriate amines with 2,2’ ‐ dichloro‐dialkyl ether Reduction of /3‐morpholinopropiophenones Hydrogenation of aromatic substituted N‐alkylmorpholines Hydrogenation of unsaturated Mannich bases Some of the synthesized compounds showed a distinct fungicidal activity especially against Rhizoctonia solani, Erysiphe cichoracearum, and Erysiphe graminis.