The Complete Genomic Sequence of XJ-160 Virus Fisrtly Isolated in China
Our study showed that the complete genomic sequence of XJ 160 virus contains 11?626nt, exclusive of 5′cap and 3′ poly A, coding for 3?731 amino acids. The non structural region is comprised of 7?461 nt (60 7?523), coding for four non-structural proteins (nsp1 4; 2?486 amino acids ). The structural region contains 3?738 nt (7?568-1,1306), coding for 1?245 amino acids (capsid, E1-3, 6K). There are three of 59nt, 45nt, 323nt noncoding regions in 5′ end, a junction between non structural and structural regions and a 3′end. XJ 160 virus conserves all consensus sequence elements commonly found in alphaviruses. Compared with Sindbis viurs AR339 (strain HRSP), significant divergence was found in the XJ 160 sequence. Only 82% nucleotides and 91.4% amino acids were shared by the two strains. We have submitted this sequence to GenBank (AF1037280).