Vitamin B6 status, MTHFR and hyperhomocysteinaemia.
Sir, transmethylation pathway is impaired by the possession of a thermolabile MTHFR allele, that the transMild hyperhomocysteinaemia is accepted as a major risk factor for vascular disease, conferring an approxisulphuration pathway will take over. It might therefore be expected that serum vitamin B 6 concentramately three-fold relative risk.1 We have shown previously that homozygosity for the thermolabile tions would be lower in those possessing the thermolabile allele. Vitamin B 6 was measured in methylene tetrahydrofolate reductase (MTHFR) genotype was associated with higher concentrations of serum by HPLC according to Brain and Reynolds (1992).3 The results are shown by genotype in the total plasma homocysteine (tHcy) in a working male population aged 30–49 years (n=625). We also table below. The trend in vitamin B 6 values by genotype is showed that serum folate concentrations were related to the expression of the genotype; in men with folate apparent, yet does not reach statistical significance ( p=0.24) due to the wide spread of data. It must below the median value, a difference in tHcy between genotypes existed. This did not persist in be noted, however, that the magnitude of increase in mean concentration of vitamin B 6 between homomen with folate levels above the median value.2 We would now like to report the results for zygous thermolabiles (+/+) and homozygous normals (−/−)—a value of 21%—is comparable to vitamin B 6 . Homocysteine is either remethylated to S-adenosylmethionine, in which case it is initially that shown by folate and vitamin B 12 (32% and 20%, respectively). Vitamin B 6 was not correlated with remethylated to methionine by the vitamin-B 12 dependent enzyme methionine synthase, using homocysteine, folate or vitamin B 12 . Using a value of 30 pmol/l as an optimal/sub5-methyl tetrahydrofolate as the methyl donor, or disposed of by the transsulphuration pathway in optimal cut-off point,4 we found that 47% of the subjects in our population were sub-optimal for which the initial step is its condensation with serine to form the thioether cystathionine through the action vitamin B 6 . We can conclude that, in this study, vitamin B 6 of the vitamin-B 6 -dependent enzyme cystathionineb-synthase. It is therefore conceivable that if the did not play a major role in determining the levels