Metal‐Free Oxidative Cyclization of o‐Acylphenols for the Construction of 2‐Aminobenzofuran‐3(2H)‐ones
An efficient metal-free approach to the synthesis of 2-aminobenzofuran-3(2H)-ones has been developed. Using TBHP as an oxidant and I2 (or TBAI) as catalyst, 2-acylphenols were treated with secondary amines to provide 2-aminobenzofuran-3(2H)-one derivatives in moderate to good yields. A possible reaction pathway for the formation of 2-dimorpholinobenzofuran-3(2H)-one is also discussed herein.