Preventive and thera eutic effects of sesame oil on glucocorticoid-induced osteoporosis in rats
Objective: To study osteoporosis of glucocorticoid-induce and investigate effects of sesame oil on rats. Methods: thirty-two male rats were randomized into 4 equal groups, and were given intragastric administration with distilled water (NS), glucocorticoid (GC) at the daily dose of 3.5 mg/kg. GC plus SO at 5 mL/kg·d (GC+SO group), and GC plus ST at 5 mL/kg.d (GC+ST group). Left elbow-bone hydroxyproline, calcium and phosphate contents were measured in the rats; with the left femur taken for bone density; with the right femur taken for bone biomechanical test. Results: long-term administration of prednisone acetate could inhibit the growth of body weight on rats (P0.01), the indicators reflecting the amount of bone and bone quality apreventive effect in varying degrees (P 0.01 or P 0.05). Conclusions: long -term use of prednisone acetate can induce bone loss, reduce bone mineral density and bone biomechanical properties. Sesame oil under the given dosage plays a role on preventing rat's osteoporosis induced by prednisone acetate.