Determination of Seven N-Nitrosamines in Eutrophic Drinking Water after Chlorination by High Performance Liquid ChromatographyTandem Mass Spectrometry
A method based on solid phase extraction-liquid chromatography-tandem mass spectrometry for determination of 7 nitrosamines( NAms)( NDMA,NMEA,NDEA,NDPA,NDBA,NPyr,NPip) in eutrophic drinking water was presented. The detection limits for NAms were 5. 0,14,8. 6,3. 6,2. 9,6. 3and 4. 9 ng / L,respectively,and correlation coefficients for all NAms were over 0. 999. The recoveries ranged from 80% to 120% except NDBA,which was about 60% and RSDs for all NAms were between 1. 4% and12. 6%. Matrix effects were evaluated by the ratio of the slope of matrix-matched and solvent-based calibration curves. The matrix effects in algae suspension ranged from 0. 79 to 0. 94 for 7 NAms,and the range of matrix effects in disinfected algae suspension for other was 0. 63- 0. 96 except NDMA( 0. 36). The method was applied to determine nitrosamines in tap water,eutrophic drinking water landscape water and algae suspension after chlorination and chloramination.