DNA vaccine pcD-flaB protects guinea pigs from Leptospira infection
Objective To observe the protective effects of the DNA vaccine pcD-flaB on guinea-pigs from the infection by pathogenic Leptospira . Methods DNA vaccine pcD-flaB was given to the healthy guinea pigs i.m. on day 0, and boost seven days later. The animals were then challenged with three serovars of pathogenic Leptospira — L.serovar lai, L.serovar linhai and L.serovar pomona respectively. Results DNA vaccine pcD-flaB protected guinea pigs from leptospiral infection and the protective rates against the three serovars were 8/9, 9/9 and 9/9 respectively. Conclusion DNA vaccine pcD-flaB provided protection not only from the same serovar of Leptospira infection, but also from the different serovars of Leptospira infection.