Localizing the Nanodeformation Impact of Magnetic Nanoparticles on Macromolecular Objects by Physical and Biochemical Means
A new magnetomechanical approach in biomedicine is described. It is based on the rotational oscillations of magnetic nanoparticles (MNPs) in a non-heating magnetic field (MF) at frequencies of 0.1–1000 Hz. Nanodeformations induced in associated macromolecules can be used for selective control of their properties. Models of local molecular effects are presented, and the possibility of inducing biochemical responses through the deformation of biomembranes and membrane structures is assessed. A way of macroscopically limiting the MNP activation volume in a gradient MF is proposed.