Neu(ronal) custodians of cutaneous immunity
Sensory neurons have surfaced as key instigators of skin inflammation. In this issue of Cell, Zhang et al. define an anti-inflammatory Langerhans cell (LC)-neuron-mast cell (MC) circuit that underlies skin immune homeostasis. They uncover a role for LCs in maintaining innervation of MrgprD+ nonpeptidergic neurons that restrain MC activation via glutamate secretion.