Comparing cryo-EM structures.
Electron cryo-microscopy (cryo-EM), is a rapidly emerging method for the determination of macromolecular complexes with an expanding presence in both the scientific literature and public data archives. Indeed, its role in moving biochemistry into a new era was recognized by the 2017 Nobel Prize in Chemistry to Jacques Dubochet, Joachim Frank, and Richard Henderson (nobelprize.org/prizes/chemistry/2017). EM Data Bank (EMDB) now holds more than 6500 cryo-EM density maps, and Protein Data Bank (PDB) holds more than 2500 structure coordinates, contributed by the growing cryo-EM community (Patwardhan and Lawson, 2016).