Programmed cell death 1 ligand (PD-L1) on T cells generates Treg suppression from memory
A recent study shows that programmed cell death 1 ligand (PD-L1) on activated T cells promotes their conversion to suppressive inducible regulatory T cells (iTregs), preferentially from among memory T cells. This new mechanism may normally protect against autoimmunity but is dysregulated in rheumatoid arthritis.