RNA-Binding Proteins Chaperone Ribonucleoprotein Complex Assembly to Solve the RNA-Folding Problem
The inherent tendency of RNAs to misfold is a major problem that can impede efficient assembly of essential ribonucleoprotein complexes (RNPs), such as ribosomes. In this issue of Cell, Duss et al., (2019) and Rogers and Woodson (2019) reveal how transient RNA-protein interactions can chaperone RNA folding during RNP assembly.