Correction: HER2 Phosphorylation Is Maintained by a PKB Negative Feedback Loop in Response to Anti-HER2 Herceptin in Breast Cancer
The authors would like to clarify that some of the blots previously depicted in Fig 1E and Fig 2B were for different experiments and were included in error. The correct blots for Fig 1E and part of Fig 2B could not be located. These panels have therefore been removed from the revised versions included here after a careful assessment and investigation determined that the results for which the original figure panels were cited are supported elsewhere in this article, and that removal of these panels does not affect the conclusions of the paper. The authors have provided new versions of Figs 1–5 to accommodate these changes. These revised figures now also clearly indicate blot splices that were not previously indicated or declared in Figs 1F and 2F, and replace incorrectly spliced blots with the un-spliced originals in Fig 4B. Those blots that are from the same experiment and share controls are now clearly indicated in the figure legends for Figs 1A, 2A, 2B, 2E, 3A and 5C. The authors have also corrected the inhibitor concentrations in the legend to Fig 5. The text in the Results sections titled “The effects of acute Herceptin treatment on HER3 and PKB phosphorylation” and “The discordant effects of Herceptin on ERK and PKB pathways” has been edited to accommodate the removal of panel E in Fig 1, and the rearrangement of panel F in Fig 1, as explained above. The text in the Results section titled “HER2 phosphorylation is maintained by its dimerisation with other HER receptors through ligand release” has been edited to accommodate the removal of part of Fig 2B. The corrected text, Figs 1–5 and their respective legends are included in this correction.