The most versatile of all reactive intermediates?
The iron(II)- and 2-oxoglutarate-dependent oxygenases catalyze varied oxidative reactions. Spectroscopic analyses on the catalytic cycle of the chlorinating enzyme CytC3 reveal the presence of chloride–iron(IV)–oxo complexes, expanding the scope of chemistry known to be catalyzed by non-heme iron-oxo species.