Peptide Decorated Gold Nanoparticles as Functional Nano Capping Agent of Mesoporous Silica Container for Targeting Drug Delivery.
A stimuli responsive drug delivery system (DDS) with bioactive surface is constructed by end capping mesoporous silica nanoparticles (MSNs) with functional peptide coated gold nanoparticles (GNPs) MSNs are first functionalized with acid labile a amide b carboxyl groups to carry negative charges, and then capped with positively charged GNPs that are decorated with oligo lysine containing peptide. The resulting hybrid delivery system exhibits endo/lysosomal pH triggered drug release, and the incorporation of RGD peptide facilitates targeting delivery to avb3 integrin overexpressing cancer cells. The system can serve as a platform for preparing diversified multifunctional nanocomposites using various functional inorganic nanoparticles and bioactive peptides.
ACS applied materials interfaces