Clinical relevance of antigen spreading pattern induced by CHP MAGE A4 cancer vaccination.
AIM To investigate the antigen spreading pattern in the CHP MAGE A4 vaccinated patients and analyze the clinical relevance of antigen spreading pattern as a surrogate marker of patient survival. MATERIALS METHODS 12 patients who had been injected with 300 mg of CHP MAGE A4 and 0.5 Klinische Einheit of OK 432 in more than five vaccinations were analyzed. RESULTS Increases in the anti MAGE A4 specific antibody response were observed in eight patients (66.7% compared with six patients (50% for anti NY ESO 1 and five patients (41.7% for anti MAGE A3 after five vaccinations. We identified frequent antigen spreading following MAGE A4 vaccinations without associations with the clinical response or patient prognosis. CONCLUSION Antigen spreading pattern might reflect tumor shrinkage as a response to treatment and treatment history (clinical trial registration number: UMIN000001999)
Immunotherapy