Evaluation of a new solid non aqueous self double emulsifying drug delivery system for topical application of quercetin
Abstract This study aimed to the evaluation of a new solid non aqueous self double emulsifying drug delivery system (SDEDDS) for topical application of quercetin. The new formulation was prepared through two step emulsification process and could spontaneously form oil in oil in water (O/O/W) double emulsions after dilution with aqueous medium, with inner oil phase mainly containing the drug. Solid state characterisation was performed by DSC and X ray powder diffraction. Furthermore, the optimised QT SDEDDS displayed sustained release profile and was found to be stable up to 30 days under 4 degC and 25 degC. Antioxidant capacities showed that quercetin could be protected by the solid non aqueous SDEDDS. Compared with the quercetin ethanol aqueous solution, the QT SDEDDS exhibited higher permeation ability, and significantly increased accumulation of quercetin in the skin. These studies demonstrated that the solid non aqueous SDEDDS might be a promising carrier for topical application of poorly water soluble and simultaneously poorly oil soluble drugs, such as quercetin.
Journal of microencapsulation