Metabolic Syndrome and Risk of Cancer A systematic review and meta analysis
RESULTSdWe analyzed 116 datasets from 43 articles, including 38,940 cases of cancer. In cohort studies inmen, the presence of metabolic syndrome was associatedwith liver (relative risk 1.43, P, 0.0001) colorectal (1.25, P, 0.001) and bladder cancer (1.10, P 0.013) In cohort studies in women, the presence of metabolic syndrome was associated with endometrial (1.61, P 0.001) pancreatic (1.58, P, 0.0001) breast postmenopausal (1.56, P 0.017) rectal (1.52, P 0.005) and colorectal (1.34, P 0.006) cancers. Associations with metabolic syndrome were stronger in women than in men for pancreatic (P 0.01) and rectal (P 0.01) cancers. Associations were different between ethnic groups: we recorded stronger associations in Asia populations for liver cancer (P 0.002) in European populations for colorectal cancer in women (P 0.004) and in U.S. populations (whites) for prostate cancer (P 0.001)