Mesoporous silica nanoparticles with organo bridged silsesquioxane framework as innovative platforms for bioimaging and therapeutic agent delivery.
Mesoporous silica material with organo bridged silsesquioxane frameworks is a kind of synergistic combination of inorganic silica, mesopores and organics, resulting in some novel or enhanced physicochemical and biocompatible properties compared with conventional mesoporous silica materials with pure Si O composition. With the rapid development of nanotechnology, monodispersed nanoscale periodic mesoporous organosilica nanoparticles (PMO NPs) and organo bridged mesoporous silica nanoparticles (MSNs) with various organic groups and structures have recently been synthesized from 100% or less, bridged organosilica precursors, respectively. Since then, these materials have been employed as carrier platforms to construct bioimaging and/or therapeutic agent delivery nanosystems for nano biomedical application, and they demonstrate some unique and/or enhanced properties and performances. This review article provides a comprehensive overview of the controlled synthesis of PMO NPs and organo bridged MSNs, physicochemical and biocompatible properties, and their nano biomedical application as bioimaging agent and/or therapeutic agent delivery system.
Biomaterials