An Evaluation of the Efficacy of Selective Alpha Blockers in the Treatment of Children with Neurogenic Bladder Dysfunction Preliminary Findings
The aim of this study was to assess the usefulness of selective a1 blockers in children with neurogenic urinary tract dysfunctions and increased leak point pressure (LPP) 14 children from age 6 to 16 years with neurogenic urinary tract dysfunctions (neurogenic bladder) and LPP 40 cm H2O were enrolled in the study. All patients received a selective a1 blocker (doxazosin) for 6 8 weeks with an initial dosage of 0.03 mg/kg. During the observation period the continuation of oral anticholinergics, Clean Intermittent Catheterization (CIC) observation of "urinary dryness" and urinary incontinence periods were recommended. Patients were scheduled for a follow up visit and urodynamic investigation after 6 8 weeks after the doxazosin therapy was started. In 4 patients, urine leakage occurred at lower pressures; in 9 patients, no significant changes in urine leak point pressures were detected; in 3 patients, there was a significant increase in the bladder capacity; in one patient, deterioration in continence was noted. The differences both in LPP and LPV before and after the treatment were not statistically significant. Our observations are consistent with the conclusions from other studies and showed no evident efficacy of doxazosin in children with neurogenic bladder.
International journal of environmental research and public health