Clinical features and treatment of hypertriglyceridemia induced acute pancreatitis during pregnancy: A retrospective study
Aim: To analyze the features and treatment of hypertriglyceridemia induced acute pancreatitis (HTGP) during pregnancy. Methods: A retrospective study of 21 pregnant women diagnosed with acute pancreatitis (AP) was performed. Patients were divided into acute biliary pancreatitis (ABP) HTGP, and idiopathic groups according to etiology. Results: 95% of the patients were in the third trimester of gestation. The percentage of patients with HTGP was higher than that of ABP (48% vs.14% The percentage of severe acute pancreatitis (SAP) in the HTGP group was higher than that in the ABP group (40.0% vs.0% The Ranson scores for moderately severe acute pancreatitis (MSAP) and SAP in the HTGP group were significantly different (2.50 0.58 vs.3.60 0.89, P 0.05, respectively) The mean serum triglyceride (TG) levels in the MSAP and SAP HTGP groups were not significantly different (18.81 11.13 vs. 30.53 24.20 mmol/L, P 0.05, respectively) In the HTGP group, there were five patients given plasma exchange therapy and five not. Plasmapheresis decreased the incidence of systemic inflammatory response syndrome (SIRS) from 100% to 28.6% and the TG level from 20.36 7.41 mmol/L to 5.23 3.62 mmol/L (P 0.05) The length of hospitalization of the plasmapheresis group was shorter than that of the nonplasmapheresis group (17.3 6.7 days vs. 37.0 20.8 days) Conclusions: Plasma exchange may be safe and effectively administered for HTGP patients during pregnancy with SIRS or multiple organ dysfunction syndrome (MODS) J. Clin. Apheresis 31:571 578, 2016. (c) 2015 Wiley Periodicals, Inc.
Journal of clinical apheresis