The Mediterranean Diet and Cognitive Function among Healthy Older Adults in a 6 Month Randomised Controlled Trial: The MedLey Study
Evidence from a limited number of randomised controlled intervention trials (RCTs) have shown that a Mediterranean dietary pattern may reduce the risk of cognitive decline and enhance cognitive function among healthy older adults. However, there are currently no data in non Mediterranean older adult populations. The present study aimed to address this gap by examining the effect of a Mediterranean dietary pattern (MedDiet) for six months on aspects of cognitive function in a randomised controlled intervention trial (the MedLey study) that extended for a duration of 18 months. In the final analysed cohort, a total of 137 men and women (mean age of 72.1 5.0 years) randomly assigned to either a MedDiet or control diet (HabDiet) (i.e. habitual dietary intake) were assessed on a comprehensive neuropsychological test battery, including 11 individual tests. In multivariable adjusted models, the MedDiet group did not perform significantly better than the HabDiet control group for executive functioning (adjusted mean differences: +2.53, 95% CI 2.59 to 7.65, p 0.33) speed of processing (adjusted mean differences: +3.24, 95% CI 1.21 to 7.70, p 0.15) memory (adjusted mean differences: +2.00, 95% CI 3.88 to 7.88, p 0.50) visual spatial ability (adjusted mean differences: +0.21, 95% CI 0.38 to 0.81, 0.48) and overall age related cognitive performance (adjusted mean differences: +7.99, 95% CI 4.00 to 19.9, p 0.19) In conclusion, this study did not find evidence of a beneficial effect of a MedDiet intervention on cognitive function among healthy older adults.
Nutrients