Computer modeling of epilepsy: opportunities for drug discovery.
Analysis of the brain as a dynamical system can assist drug development for dynamical diseases such as epilepsy. The pathological trajectories that make up a seizure differ significantly from the physiological trajectories of normal brain function. These trajectories depend on parameters conductances and time constants of ion channels and synapses that can be modified by drugs. Drug development will benefit by taking account of the way in which multiple parameters multiple drug targets produce trajectory alterations. This may lead us to reconsider potential benefits of multi target polypharmacy, of drug cocktails, and of so called "dirty drugs" (drugs with activity at multiple locations)
Drug discovery today. Disease models