Effects of Moringa oleifera Lam Moringaceae Seeds in Rats Fed with High Fat Diet
The present work aims to study the potential effect of Moringa Oleifera (MO) seed oil and seed ethanol extract to give more protection against hyperlipidemia Thirty male albino rats were used over 30 days period. The animals were divided into (5) groups, wherein groups number (1) represent control which were fed basal diet, while group number (2) was received high fat diet to serve as hyperlipidemic group. Other three groups allowed to feed high fat diet supplemented with seed oil seed ethanol extract and atrovastatin, group number (3) treated simultaneously with moringa seed oil, fourth group treated with moringa seed ethanol extract while the last group treated with atrovastatin. At the end of the experimental period, blood samples were collected to determine lipid profile and determine the kidney functions include urea nitrogen and creatinine. Also liver was removed surgically for histopathological observation. From the obtained results we concluded that group of rats fed on high fat diet were considered as a major risk factor for hyperlipidemia disease. Our results could be summarized that moringa seed oil and moringa seed ethanol extract were considered the best for causing a reduction of TC, TG and LDL Also, kidney function has been improved and there were significant reduction urea than that of positive control group. It could be concluded that moringa seed oil and moringa seed ethanol extract under study are useful for the treatment of hyperlipidemia. Keyword: Moringa; Oil; Extracts; Triglycerides; Cholesterol