Signaling Pathways in Osteoclast Differentiation
Osteoclasts are multinucleated cells of hematopoietic origin that are responsible for the degradation of old bone matrix. Osteoclast differentiation and activity are controlled by two essential cytokines, macrophage colony stimulating factor (M CSF) and the receptor activator of nuclear factor kB ligand (RANKL) M CSF and RANKL bind to their respective receptors c Fms and RANK to stimulate osteoclast differentiation through regulation of delicate signaling systems. Here, we summarize the critical or essential signaling pathways for osteoclast differentiation including M CSF c Fms signaling, RANKL RANK signaling, and costimulatory signaling for RANK.
Chonnam medical journal