Scalable Production of Sensor Arrays Based on High Mobility Hybrid Graphene Field Effect Transistors.
We have developed a scalable fabrication process for the production of DNA biosensors based on gold nanoparticle decorated graphene field effect transistors (AuNP Gr FETs) where monodisperse AuNPs are created through physical vapor deposition followed by thermal annealing. The FETs are created in a four probe configuration, using an optimized bilayer photolithography process that yields chemically clean devices, as confirmed by XPS and AFM, with high carrier mobility (3590 710 cm2/V*s) and low unintended doping (Dirac voltages of 9.4 2.7 V) The AuNP Gr FETs were readily functionalized with thiolated probe DNA to yield DNA biosensors with a detection limit of 1 nM and high specificity against noncomplementary DNA. Our work provides a pathway toward the scalable fabrication of high performance AuNP Gr FET devices for label free nucleic acid testing in a realistic clinical setting.
ACS applied materials interfaces