Role of sympathetic nervous system in rat model of chronic visceral pain
Changes in central pain modulation have been implicated in generalized pain syndromes such as irritable bowel syndrome (IBS) We have previously demonstrated that reduced descending inhibition unveils a role of sympathoneuronal outflow in decreasing peripheral sensory thresholds, resulting in stress induced hyperalgesia. We investigated whether sympathetic nervous system (SNS) exacerbation of pain sensation when central pain inhibition is reduced is relevant to chronic pain disorders using a rat colon irritation (CI) model of chronic visceral hypersensitivity with hallmarks of IBS.
Neurogastroenterology and motility the official journal of the European Gastrointestinal Motility Society