Zwitterionic Cocrystals of Flavonoids and Proline: Solid State Characterization, Pharmaceutical Properties, and Pharmacokinetic Performance
We utilized the concepts of crystal engineering to acquire cocrystals of d/l proline with a variety of flavonoids and further evaluated the impact on solubility and pharmacokinetic of flavonoids. We have synthesized and characterized six d/l proline cocrystals with flavonoids and their single crystal structures were revealed. The powder dissolution profiles were determined and the pharmacokinetic properties for Kae l Pro were analyzed and compared with the corresponding physical mixture. d/l Proline was found to be a suitable coformer for a variety of structural similar flavonoids. This study may offer an alternative approach for the development of these widely used flavonoids.