New amino bisphosphonate compound for skeletal imaging: Comparison study with methylenediphosphonic acid (MDP) and (1 hydroxyethane 1,1 diyl) diphosphonic acid (HEDP)
Abstract A novel bisphosphonate derivative (1 aminoethane 1,1 diyl)diphosphonic acid (AEDP) has been prepared and successfully labeled with 99mTc at high labeling yields. The in vivo biodistribution of 99mTc AEDP has been investigated and compared with two reference compounds Tc 99m methylene diphosphonate (99mTc MDP) and Tc 99m (1 hydroxyethylidene) diphosphonate (99mTc HEDP) The biodistribution studies have demonstrated a high uptake of the radiotracer 99mTc AEDP in the bone and a rapid clearance from the blood (such as the two technetium labeled bone imaging agents in current use: 99mTc MDP and 99mTc HEDP) Additionally, the scintigraphic images of 99mTc AEDP in normal rats have revealed high selective skeletal uptake.