Sequential and compartmentalized action of Rabs, SNAREs, and MAL in the apical delivery of fusiform vesicles in urothelial umbrella cells
As major urothelial differentiation products, uroplakins are targeted to the apical surface of umbrella cells. Via the sequential actions of Rabs 11, 8, and 27b and their effectors, uroplakin vesicles are transported to a subapical zone above a K20 network and fuse, via a SNARE mediated and MAL facilitated step, with the urothelial apical membrane.
Molecular biology of the cell