Association between ABO blood group and HCV related hepatocellular carcinoma risk in China
Abstract The ABO blood group has previously been reported to be associated with risk for certain malignancies; however, data about the risks for hepatocellular carcinoma (HCC) according to blood type are limited. Thus, we conducted a retrospective case control study to investigate whether the ABO blood group contributes to hepatitis C virus (HCV) infection induced HCC. From January 2010 to June 2016, 447 consecutive patients with chronic HCV infection were recruited. Of these patients, 217 had HCV related HCC, and 230 had chronic hepatitis C (CHC) without HCC. We performed multivariate logistic regression to probe the association between the ABO blood group and HCC risk. Compared with subjects with blood type O, patients with blood type A had an adjusted odds ratio (AOR) of 3.301 (95% confidence interval [CI] 1.927 5.653) for HCC after adjusting for age and gender. We found statistically significant associations between blood type A and HCC risk for both men (AOR [95% CI] 4.192 [1.959 8.973] and women (AOR [95% CI] 2.594 [1.231 5.466] and for patients aged below 70 years <60 years: AOR [95% CI] 3.418 [1.338 8.734] 60 69 years: AOR [95% CI] 3.917 [1.730 8.867] Thus, HCC risk is associated with ABO blood type in Chinese CHC patients, and CHC patients with blood type A are more susceptible to HCV related HCC than patients with other blood types.
Medicine