Induction of a synuclein aggregate formation by CSF exosomes from patients with Parkinson's disease and dementia with Lewy bodies
Stuendl et al. show that CSF exosomes of patients with Parkinson's disease or dementia with Lewy bodies contain a synuclein and induce a synuclein aggregation in a reporter cell line. Thus, exosomes may support inter neuronal transmission of a synuclein pathology. CSF exosomal a synuclein may serve as a biomarker in a synuclein related neurodegeneration.
Brain a journal of neurology