Prognosis of unresectable hepatocellular carcinoma: Comparison of seven staging systems (TNM, Okuda, BCLC, CLIP, CUPI, JIS, CIS) in a Chinese cohort.
305 Background: Many liver staging systems that include the tumor stage and the extent of liver function have been developed. However, Prognosis assessment for hepatocellular carcinoma (HCC) remains controversial. In this study, the performances of 7 staging systems were compared in a cohort of patients with HCC who underwent non surgical treatment. Methods: A total of 196 consecutive patients with HCC who underwent non surgical treatment seen between January 1, 2004, and December 31, 2007, were included. Performances of TNM sixth edition, Okuda, Barcelona Clinic Liver Cancer (BCLC) Cancer of the Liver Italian Program (CLIP) Chinese University Prognostic Index (CUPI) Japan Integrated Staging (JIS) and China integrated score (CIS) have been compared and ranked using concordance index (c index) Predictors of survival were identified using univariate and multivariate Cox model analyses. Results: The median survival time for the cohort was 7.6 months (95% CI 5.6 9.7) The independent predictors of surviv.