Non aqueous self double emulsifying drug delivery system: A new approach to enhance resveratrol solubility for effective transdermal delivery
Abstract trans Resveratrol, a naturally occurring polyphenol has attracted considerable interest for its beneficial potentials for human health. However, the biological effects of trans resveratrol appear strongly limited by its low solubility, which is a barrier to the development of therapeutic applications. Herein, we developed a novel formulation, non aqueous self double emulsifying drug delivery systems (SDEDDS) by formulating mixtures of hydrophilic surfactants and oil in oil (O/O) emulsions, which could improve trans resveratrol solubility through formulations optimization. SDEDDS can spontaneously emulsify to oil in oil in water double emulsions in the mixed aqueous solution, with drugs encapsulated in the internal oil phase of the double emulsions. We employed non aqueous SDEDDS to improve the skin retention of trans resveratrol solubility, a polyphenol drug with poor solubility. The optimized trans resveratrol SDEDDS was found to be stable up to 3 months under 30 degC and 40 degC. In vitro transdermal studies revealed that trans resveratrol from SDEDDS will most likely be higher than the drug permeation from the same dose of the free form aqueous solution. These studies demonstrated that non aqueous SDEDDS might be a promising strategy for topical delivery of poor solubility drug.