Combining transrectal ultrasound and CT for image guided adaptive brachytherapy of cervical cancer: Proof of concept.
PURPOSE To investigate the feasibility of a treatment planning workflow for three dimensional image guided cervix cancer brachytherapy, combining volumetric transrectal ultrasound (TRUS) for target definition with CT for dose optimization to organs at risk (OARs) for settings with no access to MRI. METHODS AND MATERIALS A workflow for TRUS/CT based volumetric treatment planning was developed, based on a customized system including ultrasound probe, stepper unit, and software for image volume acquisition. A full TRUS/CT based workflow was simulated in a clinical case and compared with MR or CT only delineation. High risk clinical target volume was delineated on TRUS, and OARs were delineated on CT. Manually defined tandem/ring applicator positions on TRUS and CT were used as a reference for rigid registration of the image volumes. Treatment plan optimization for TRUS target and CT organ volumes was performed and compared to MRI and CT target contours. RESULTS TRUS/CT based contouring, applicator reconstruction, image fusion, and treatment planning were feasible, and the full workflow could be successfully demonstrated. The TRUS/CT plan fulfilled all clinical planning aims. Dose volume histogram evaluation of the TRUS/CT optimized plan (high risk clinical target volume D90, OARs D2cm3 for) on different image modalities showed good agreement between dose values reported for TRUS/CT and MRI only reference contours and large deviations for CT only target parameters. CONCLUSIONS A TRUS/CT based workflow for full three dimensional image guided cervix brachytherapy treatment planning seems feasible and may be clinically comparable to MRI based treatment planning. Further development to solve challenges with applicator definition in the TRUS volume is required before systematic applicability of this workflow.
Brachytherapy