Personalized prescription feedback to reduce antibiotic overuse in primary care: rationale and design of a nationwide pragmatic randomized trial
BackgroundAntimicrobial resistance has become a serious worldwide public health problem and is associated with antibiotic overuses. Whether personalized prescription feedback to high antibiotic prescribers using routinely collected data can lower antibiotic use in the long run is unknown.MethodsWe describe the design and rationale of a nationwide pragmatic randomized controlled trial enrolling 2900 primary care physicians in Switzerland with high antibiotic prescription rates based on national reimbursement claims data. About 1450 physicians receive quarterly postal and online antibiotic prescription feedback over 24 months allowing a comparison of the individual prescription rates with peers. Initially, they also receive evidence based treatment guidelines. The 1450 physicians in the control group receive no information. The primary outcome is the amount of antibiotics prescribed over a one year period, measured as defined daily doses per 100 consultations. Other outcomes include the amount of antibiotics prescribed to specific age groups <6, 6 to 18, 19 to 65, >65 years) to male and female patients, in addition to prescriptions of specific antibiotic groups. Further analyses address disease specific quality indicators for outpatient antibiotic prescriptions, the acceptance of the intervention, and the impact on costs.DiscussionThis trial investigates whether continuous personalized prescription feedback on a health system level using routinely collected health data reduces antibiotic overuse. The feasibility and applicability of a web based interface for communication with primary care physicians is further assessed.Trial registrationClinTrials.gov NCT01773824 (Date registered: August 24, 2012)
BMC Infectious Diseases