The pathogenesis of Parkinson Disease the microbiota gut brain axis
3 Resumo: 4 Introduction 5 The Parkinson's Disease 5 The synuclein spreading hypothesis 6 The Braak's staging system 8 The microbiota 9 The microbiota gut brain axis: a novel concept in PD 9 Other environmental factors 13 Therapeutics and biomarkers/Future directions 14 Diagnosis 14 Therapeutics and disease management: 14 Conclusion 17 References: 18 ABREVIATIONS/ACRONIMS: ANS Autonomic Nervous System CNS Central Nervous System DMNV Dorsal Motor Nucleus of the Vagus Nerve ENS Enteric Nervous System GI Gastrointestinal LPS Lipopolysaccharide NMS Non Motor Symptoms PD Parkinson's Disease PIGD Postural Instability and Gait Difficulty SIBO Small Intestine Bacterial Overgrowth TLR Toll Like Receptor