Polymer Capsules for Plaque Targeted In Vivo Delivery.
Targeted polymer capsules can selectively bind to unstable plaques in mice after intravenous injection. Different formulations of the capsules are explored with a synthetic/biopolymer hybrid capsule showing the best stability and small molecule drug retention. The synthetic polymer is composed of pH sensitive blocks (PDPA) low binding blocks (PEG) and click groups for postfunctionalization with targeting peptides specific to plaques.
Advanced materials