Transdermal solid delivery of epigallocatechin 3 gallate using self double emulsifying drug delivery system as vehicle: Formulation, evaluation and vesicle skin interaction
The present study investigated a self double emulsifying drug delivery system loaded with epigallocatechin 3 gallate to improve epigallocatechin 3 gallate skin retention. The long chain solid lipids (cetostearyl alcohol) and macadamia oil were utilized as a carrier to deliver the bioactive ingredient. Response surface methodology was used to optimize the formulation, and the solid lipid to total lipid weight ratio, concentration of epigallocatechin 3 gallate and hydrophilic surfactant on skin retention were found to be the principal factors. The optimum formulation with high encapsulation efficiency (95.75% self double emulsification performance (99.58% and skin retention (87.24% were derived from the fitted models and experimentally examined, demonstrating a reasonable agreement between experimental and predicted values. Epigallocatechin 3 gallate self double emulsifying drug delivery system was found to be stable for 3 months. Transdermal studies could explain a higher skin diffusion of epigallocatechin 3 gallate from the self double emulsifying drug delivery system compared with EGCG aqueous solution. In vitro cytotoxicity showed that epigallocatechin 3 gallate self double emulsifying drug delivery system did not exert hazardous effect on L929 cells up to 1:10.
Journal of biomaterials applications