Giant Cell Arteritis which Developed after the Administration of Granulocyte colony Stimulating Factor for Cyclic Neutropenia.
A 78 year old woman diagnosed with cyclic neutropenia 5 years previously had been treated with recombinant granulocyte colony stimulating factor (G CSF) She developed fever, tenderness and distension of temporal arteries after the treatment with G CSF. Magnetic resonance imaging and ultrasonography revealed wall thickening of the temporal arteries. She was therefore diagnosed with giant cell arteritis (GCA) Small vessel vasculitis has been reported as a complication of G CSF. However, the development of large vessel vasculitis after G CSF treatment is quite rare. To our knowledge, the present case is the first report of GCA suspected to be associated with coexisting cyclic neutropenia and G CSF treatment.
Internal medicine