Meta Analysis on the Correlation Between APOM rs805296 Polymorphism and Risk of Coronary Artery Disease
Background The present meta analysis aimed to summarize the inconsistent findings on the association of apolipoprotein M gene (ApoM) rs805296 polymorphism with the risk of coronary artery disease (CAD) and to obtain a more authentic result about this topic. Material/Methods A total of 7 available articles were identified through electronic databases PubMed, EMBASE, and Chinese National Knowledge Infrastructure (CNKI) and their useful data were carefully extracted. The relationship between ApoM rs805296 polymorphism and CAD risk was assessed by odds ratios (ORs) and corresponding 95% confidence intervals (95% CIs) which were calculated using the fixed or random effects model, according to the degree of heterogeneity. Hardy Weinberg equilibrium test, sensitivity test, and publication bias examination were also performed in this meta analysis. Results According to the pooled results, ApoM rs805296 polymorphism conferred an increased risk of CAD under all the genetic contrasts: CC versus TT, CC TC versus TT, CC versus TT+TC, C versus T, and TC versus TT (OR=2.13, 95% CI=1.16 3.91; OR=1.80, 95% CI=1.50 2.17; OR=1.91, 95% CI=1.04 3.51; OR=1.72, 95% CI=1.45 2.04; OR=1.78, 95% CI=1.47 2.15) Conclusions ApoM rs805296 polymorphism may be a risk factor for developing CAD.
Medical science monitor international medical journal of experimental and clinical research