Unintended Pregnancies Observed With Combined Use of the Levonorgestrel Contraceptive Implant and Efavirenz based Antiretroviral Therapy: A Three Arm Pharmacokinetic Evaluation Over 48 Weeks
Women receiving efavirenz based antiretroviral therapy plus a contraceptive implant had significantly lower levonorgestrel pharmacokinetics than women not receiving antiretroviral therapy. An unexpected high pregnancy rate (3/20, 15% occurred in the efavirenz group, highlighting the clinical significance of this interaction.
Clinical infectious diseases an official publication of the Infectious Diseases Society of America