Activity and Toxicity of Intravenous Erwinia Asparaginase Following Allergy to E. coli Derived Asparaginase in Children and Adolescents With Acute Lymphoblastic Leukemia
Erwinia asparaginase is antigenically distinct from E.coli derived asparaginase and may be used after E.coli derived asparaginase hypersensitivity. In a single arm, multicenter study, we evaluated nadir serum asparaginase activity (NSAA) and toxicity with intravenously administered asparaginase Erwinia chrysanthemi (IV Erwinia) in children and adolescents with acute lymphoblastic leukemia (ALL) or lymphoblastic lymphoma with hypersensitivity to E.coli derived asparaginase.
Pediatric blood cancer