Still cooling after all these years: Meta analysis of pre clinical trials of therapeutic hypothermia for acute ischemic stroke
Therapeutic hypothermia is the most potent neuroprotectant for experimental cerebral ischemia, illustrated in a 2007 meta analysis published in this journal. To address recent therapeutic nihilism, we systematically reviewed recent experimental literature. Quality scoring showed considerable improvement in study design. Using several outcome measures in a variety of models and species, therapeutic hypothermia was protective compared with normothermia, with powerful and statistically significant normalized treatment effect sizes, in 60 papers comprising 216 comparisons. In the past 5 years, preclinical studies of ischemic stroke re emphasize that therapeutic hypothermia is potently effective, justifying further development in larger human clinical trials.
Journal of cerebral blood flow and metabolism official journal of the International Society of Cerebral Blood Flow and Metabolism