Pot, Atom and Step Economic (PASE) Synthesis of 2 Amino 3, 5 Dicarbonitrile 6 Thio Pyridines in Aqueous PEG 400 Promoted by Sodium Benzoate
An efficient pot, atom and step economic (PASE) sodium benzoate promoted synthesis of 2 amino pyridine 3, 5 dicarbonitriles by the reaction of aldehydes, malonitrile and thiophenol in PEG 400 in water is reported. This new protocol has the advantages of convenient procedure, eco friendliness, shorter reaction times and higher yields.