Behavioral characterization of CD36 knockout mice with SHIRPA primary screen
CD36 is a member of the class B scavenger receptor family of cell surface proteins, which plays a major role in fatty acid, glucose and lipid metabolism. Besides, CD36 functions as a microglial surface receptor for amyloid beta peptide. Regarding this, we suggest CD36 might also contribute to neuropsychiatric disease. The aim of this study was to achieve a behavioral phenotype of CD36 knockout (CD36( mice. We characterized the behavior of CD36( mice and C57BL/6J mice by subjecting them to a series of tests, which include SHIRPA primary behavioral screen test, 1% sucrose preference test, elevated plus maze test, open field test and forced swimming test. The results showed that CD36( mice traversed more squares, emitted more defecation, exhibited higher tail elevation and had more aggressive behaviors than C57BL/6J mice. The CD36( mice spent more time and traveled longer distance in periphery zone in the open field test. Meanwhile, the numbers that CD36( mice entered in the open arms of elevated plus maze were reduced. These findings suggest that CD36( mice present an anxious phenotype and might be involved in neuropsychiatric disorders.
Behavioural Brain Research