[Hypercalcemia related to PTH rP revealing malignant hepatic epithelioid hemangioendothelioma]
Hypercalcemia caused by tumor production of PTH rp occurs most often in cases of squamous cell carcinoma of the lung, aerodigestive tract cancer, gynecological cancer and lymphoma. We report an exceptional case of PTH rp related to a hepatic hemangioendothelioma. A 70 years old male admitted for deterioration of the general state. The laboratory investigations revealed hypercalcemia, related to tumor production of PTH rp. Imaging revealed tumoral hepatic lesions. Histopathological study and immunohistochemistry showed diffuse response for CD31 marker, CK20 with CK7 and hepatocyt antigen The diagnosis of PTH rp related to hepatic hemangioendothelioma was make. The patient died with recurrence of fatal hypercalcemia. Management of patients presenting with humoral hypercalcemia includes a vigorous search for tumor lesions. Elevated PTH rp can be a bad prognostic factor. In front of tumoral liver lesions, a hepatic epithelioid hemangioendothelioma must be considered. Immunohistochemistry is necessary to make diagnosis.
Annales de biologie clinique