Influence of pH, temperature, and alternating magnetic field on drug release from Keggin type heteropoly acid encapsulated in iron carboxylate nanoscale metal organic framework
Nanosized mesoporous iron carboxylate [MIL 100(Fe) encapsulated Keggin phosphotungstic acid H3PW12O40 (PW) was fabricated via an environmentally friendly hydrothermal synthesis method and characterized by Fourier transform infrared spectroscopy, high resolution transmission electron microscopy, field emission scanning electron microscopy, particle size analysis, and powder X ray diffraction analysis. The metal content was analyzed by energy dispersive X ray spectroscopy. PW@MIL 100(Fe) was then studied as a drug delivery system, exhibiting the ability to entrap epirubicin (EPI) as a model drug. The drug loading efficiency, drug content, and drug release behavior of PW@MIL 100(Fe) MIL 100(Fe) and PW@HKUST 1 [where HKUST 1 is Cu3(BTC)2 with BTC benzene 1,3,5 tricarboxylic acid] were also studied. The results indicate that PW@MIL 100(Fe) possessed high adsorption capacity (28 wt% and loading efficiency (91.6 for epirubicin. Drug release from PW@MIL 100(Fe) at different pH values (5, 5.8, 6.5, and 7.4) and temperatures and with an alternative magnetic field was investigated, and the stability of the nanocarrier after EPI release was studied by Fourier transform infrared spectroscopy and field emission scanning electron microscopy. Cellular toxicity was also investigated. The results show that this is a good candidate as a future drug nanocarrier.
Research on Chemical Intermediates