Recent Progress in the Development of HIV 1 Protease Inhibitors for the Treatment of HIV/AIDS.
HIV 1 protease inhibitors continue to play an important role in the treatment of HIV/AIDS, transforming this deadly ailment into a more manageable chronic infection. Over the years, intensive research has led to a variety of approved protease inhibitors for the treatment of HIV/AIDS. In this review, we outline current drug design and medicinal chemistry efforts toward the development of next generation protease inhibitors beyond the currently approved drugs.
Journal of medicinal chemistry