Fluoroquinolone and Third Generation Cephalosporin Resistance among Hospitalized Patients with Urinary Tract Infections Due to Escherichia coli: Do Rates Vary by Hospital Characteristics and Geographic Region?
ABSTRACT This analysis of nearly 10,000 hospital associated urinary tract infection (UTI) episodes due to Escherichia coli showed that fluoroquinolone and third generation cephalosporin resistance rates were 34.5% and 8.6% respectively; the rate of concurrent resistance to both agents was 7.3% Fluoroquinolone resistance rates exceeded 25% regardless of geographic location or hospital characteristics. The findings suggest that fluoroquinolones should be reserved and third generation cephalosporins be used with caution as empirical agents for hospitalized patients with UTIs due to E. coli.
Antimicrobial Agents and Chemotherapy