Association of Interleukin 10 Gene Polymorphisms with Autoimmune Thyroid Disease: Meta Analysis
The aim of this study was to perform a meta analysis of eligible studies and to derive a precise estimate of the association between interleukin 10 (IL10) polymorphisms and susceptibility to autoimmune thyroid disease (AITD) Meta analyses were conducted on the associations between AITD and the 1082 G/A (rs1800896) 819 C/T (rs1800871) and 592 C/A (rs1800872) polymorphisms in IL10, and the haplotype of these polymorphisms and AITD. A total of 2903 AITD patients and 3060 controls in 10 eligible studies were included in the meta analysis. This meta analysis showed significant associations between IL10 at the 1082 G allele and overall AITD (OR: 1.44, 95% CI 1.13 1.82, P 0.003) but no association between the IL10 592 C allele and the 819 C allele and AITD. Subgroup studies demonstrated significant associations between the 1082 G allele and susceptibility to Graves' disease. Ethnicity specific meta analysis revealed significant associations between the 1082 G allele and AITD susceptibility in Asian populations; however, in Middle Eastern populations, no association was evident. Meta analysis of the IL10 haplotype revealed an association between the ATA haplotype and AITD (OR: 1.17, 95% CI 1.00 1.36, P 0.04) Meta analysis demonstrates that the IL10 polymorphisms are associated with susceptibility to AITD.
Scandinavian journal of immunology