The Complexity of Translating Anti angiogenesis Therapy from Basic Science to the Clinic.
Formation of new blood vessels in tumors, a process termed tumor angiogenesis, is a crucial step during oncogenic progression. Blocking tumor angiogenesis is therefore expected to have a profound impact on tumor growth. It took several decades of collective efforts to translate this intriguing idea into tangible clinical benefit. Today, anti angiogenesis agents represent standard of care therapies for multiple types of cancers, and the clinical experience has taught us many lessons about the concept and application of anti angiogenesis. This Perspective is an attempt to summarize these lessons and how they can be leveraged to improve anti angiogenesis therapy.
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