Enhancement of the Th1 phenotype immune system by the intake of Oyster mushroom (Tamogitake) extract in a double blind, placebo controlled study
Pleurotus cornucopiae (Oyster mushroom, Tamogitake) has long been eaten as a functional food for enhancement of the immune system, but its effectiveness has not been well confirmed in humans. To this end, we set up a double blind placebo controlled human clinical trial to investigate the potential of Oyster mushrooms with respect to the up regulation of the immune system. The subjects ingested Oyster mushroom extract for 8 weeks. We measured the serum cytokine levels involved in regulation of the immune system, including interferon (IFN) g, interleukin (IL) 4, IL 5, IL 10, IL 12, IL 13, and tumor necrosis factor (TNF) a. We found that intake of Oyster mushroom extract elevated IFN g (P 0.013) and IL 12, whereas serum levels of IL 10 and IL 13 and other cytokines were minimally changed. We also measured natural killer (NK) cell activity, the levels of which tended to increase, but not significantly. Taken together, these facts suggest that Oyster mushrooms have the potential to enhance the immune system, through Th1 phenotype potentiation as the macrophage IL 12 IFN g pathway. This results in activation of the cell mediated immune system as exemplified by up regulation of NK cell activity. Oyster mushroom extract may be beneficial for the prevention of various diseases, including infectious diseases and cancer, due to its stimulation of the immune system.
Journal of traditional and complementary medicine