Nano TiCl2/cellulose: an eco friendly bio based catalyst for one pot synthesis of 4H pyrimido[2,1 b]benzothiazole derivatives
Cellulose is among the most abundant natural carbon based biopolymers containing free OH groups with nucleophilic character for bonding to Lewis acids such as TiCl4. Nano TiCl2/cellulose as a bio based and eco friendly Lewis acid catalyst was prepared via reaction of nano cellulose and TiCl4 in dichloromethane as solvent under room temperature conditions. This catalyst has been characterized by Fourier transform infrared spectroscopy, field emission scanning electron microscopy, powder X ray diffraction, energy dispersive X ray spectroscopy, X ray fluorescence techniques, and transmission electron microscopy. Nano TiCl2/cellulose has been shown to effectively promote multi component synthesis of 4H pyrimido[2,1 b]benzothiazole derivatives by reaction of aldehydes, b ketoester, and 2 amino benzothiazole under thermal conditions in polyethylene glycol 400 as solvent. Simple methodology,an eco friendly catalyst, a clean procedure, easy work up, and excellent yields are some of the important advantages of this protocol.Graphical Abstract
Research on Chemical Intermediates