36976273
Discovery of a potent and selective aurora kinase inhibitor.
This communication describes the discovery of a novel series of Aurora kinase inhibitors. Key SAR and critical binding elements are discussed. Some of the more advanced analogues potently inhibit cellular proliferation and induce phenotypes consistent with Aurora kinase inhibition. In particular, compound 21 (SNS-314) is a potent and selective Aurora kinase inhibitor that exhibits significant activity in pre-clinical in vivo tumor models.
117276480
The Sun's Origin, Composition and Source of Energy
Composition: Diffusion enriches lighter elements and the lighter isotopes of each element at the solar surface. When corrected for mass fractionation, the most abundant nuclide that accreted on the Sun was shown to be Fe, the decay product of doubly-magic Ni; the next most abundant nuclide is the doublymagic O. These nuclides were recently observed in the ash of SN 1987A. The most abundant elements Fe, Ni, O, Si, S, Mg, and Ca are the seven, even-Z elements that Harkins found to comprise 99% of ordinary meteorites. The least abundant elements Li, Be and B have loosely bound nucleons, confirming a link between abundance and nuclear structure hidden beneath the Sun’s H-rich surface, with one conspicuous and important exception an excess of protons.
121130487
The Ising and anisotropy phase transitions of the periodic XY model in a transverse field
It is found that, for a periodic XY chain, the competition between periodicity and anisotropy gives rise to more than one phase-transition point at some parameter region. In this paper, the phase diagram of a period-two XY model in a transverse field is discussed. Two phase transitions, the Ising and anisotropy transitions, driven by the anisotropy parameter ?, are studied by singularities of the order parameters, the ground-state energy and the quantum entanglement. These two transitions are of second order and their traits are discussed.
119075496
HQEFT as a large component QCD and comments on the incompleteness of HQET
The heavy quark effective field theory (HQEFT) is revisited in a more intuitive way. It is shown that HQEFT is a consistent large component QCD of heavy quarks. In the nonrelativistic limit, HQEFT recovers the nonrelativistic QCD (NRQCD). The resulting new effects in the HQEFT of QCD are carefully re-examined. It is then natural to give comments on the usual heavy quark effective theory (HQET). Consistent phenomenological applications of HQEFT exhibit its interesting features and completeness in comparison with HQET. It then becomes manifest why we shall base on the HQEFT of QCD rather than HQET which is incomplete for computing 1/mQ corrections. More precise extraction for ∣Vcb∣ and ∣Vub∣ in the HQEFT of QCD is emphasized.
118041104
Correction to the Running of Gauge Couplings out of Extra Dimensional Gravity
We study the gravitational correction to the gauge couplings in the extra dimension model where the gravity propagates in the (4+n)-dimensional bulk. We show by explicit calculation in the background field method that the one-loop correction coming from graviton Kaluza-Klein states is nontrivial and tends to make the theory anti-asymptotically free. For the theory characterized with asymptotic freedom, the correction will induce a nontrivial UV-stable fixed point. This may lead to an interesting possibility that the non-abelian gauge coupling constants $g_2$ and $g_3$ in the SM and that of the gravity $g_{\kappa}$ unify at the fixed point in the limit of high energy scale.
121330294
Global analysis of D→ PV decays and SU(3) flavor symmetry breaking effects
We investigate in detail both the Cabibbo-allowed and singly Cabibbo-suppressed D→ PV decays based on the diagrammatic decomposition in the factorization formalism. Two sets of solutions discarded in the literature are picked up and discussed carefully. It is found that one of these solutions can provide satisfactory explanation in a natural manner on the process $D^+\to \overline {K}^0K^{*+}$ which is thought to be a puzzle. The relations EV+EP=0 and AV+AP=0 are badly broken, which indicates that the exchange and annihilation diagrams may receive contributions from more sources other than the $q\overline{q}$ intermediate state interactions. It is shown that, to have a consistent explanation to the experimental data with reasonable values for the parameters a1 and a2, the SU(3) symmetry breaking effects have to be considered. The SU(3) flavor symmetry breaking effects due to mass factors and due to formfactors and decay constants are analyzed in detail.
15834749
Exclusive B meson rare decays and general relations of form factors in effective field theory of heavy quarks
B meson rare decays (B --> K(K-*)ll and B --> K(*)gamma) are analyzed in the framework of effective field theory of heavy quarks. The semileptonic and penguin type form factors for these decays are calculated by using the light cone sum rules method at the leading order of 1/m(Q) expansion. Four exact relations between the two types of form factors are obtained at the leading order of 1/mQ expansion. In particular, the relations are found to hold for the whole momentum transfer region. We also investigate the validity of the relations resulting from the large energy effective theory based on the general relations obtained in the present approach. The branching ratios of the rare decays are presented and their potential importance for extracting the CKM matrix elements and probing new physics is emphasized.