24807907
Comparative genomics and function analysis on BI1 family
Bax inhibitor-1 (BI1) family contains six known genes in human. Some members of BI1 family have been proved to play important roles in cell death. Here we discuss the similarities and differences among the members of BI1 family by comparative genomics and proteomics, and report here the discovery of a novel member, tmbim1b, in Bos taurus. BI1 family is evolutionarily conserved as integral membrane proteins containing multiple membrane-spanning segments and predominantly localized to intracellular membranes, similar to Bcl-2 family proteins. They share multiple motifs and transcriptional factors within the promoter and the coding regions. They may represent regulators of cell death pathways, which are concluded from structure conservation of BI1 family.
26669443
Bottom-up discovery of frequent rooted unordered subtrees
In the past decade, XML has emerged as the standard language for information exchanging over the Internet. Due to its tree-structure paradigm, XML is superior for its capability of storing, querying, and manipulating complex data. Therefore, discovering frequent tree patterns over tree-structured data has become an interesting topic for XML data management. In this paper, we propose a tree mining algorithm, named BUXMiner, for finding a special class of frequent trees, called rooted unordered trees, from a tree-structured database. BUXMiner employs an efficient bottom-up approach to enumerate all candidate trees over a compact global tree guide and computes the frequent trees based on the tree guide. In addition to BUXMiner, we also propose a mining approach called BUMXMiner to discover the maximal frequent rooted unordered trees. We compare BUXMiner with previous tree-structure mining algorithms, namely XQPMinerTID and FastXMiner, which were also proposed to discover rooted unordered trees. The experimental results show that our algorithm outperforms XQPMinerTID and FastXMiner in terms of efficiency. The performance results from real-world applications also indicate the usefulness of our proposed tree mining algorithms in a variety of web applications, such as analysis of web page access patterns and mining frequent XML query patterns for caching.
8340253
UGE4B: An Universal Grid Environment for Bioinformatics Research
Recent years, grid technology has been used widely in the fields of scientific research. In this paper, we present a universal grid environment for bioinformatics research (UGE4B). Although there have been several similar projects successfully constructed in the world, we need to meet some unique requirements from bioinformatics research in China. UGE4B consists of 6 components, including portal, task management, data management, information server, security and computing node. As a national-wide bioinformatics research platform, UGE4B is built through interconnecting multiple sub grids provided by each bioinformatics institutes. Besides provides a universal portal to end users for bioinformatics computing and data accessing, UGE4B also supported some special bioinformatics applications
5747087
Efficient Processing of Warping Time Series Join of Motion Capture Data
Discovering non-trivial matching subsequences from two time series is very useful in synthesizing novel time series. This can be applied to applications such as motion synthesis where smooth and natural motion sequences are often required to be generated from existing motion sequences. We first address this problem by defining it as a problem of l-e-join over two time series. Given two time series, the goal of l-e-join is to find those non-trivial matching subsequences by detecting maximal l-connections from the e-matching matrix of the two time series. Given a querying motion sequence, the l-e-join can be applied to retrieve all connectable motion sequences from a database of motion sequences. To support efficient l-e-join of time series, we propose a two-step filter-and-refine algorithm, called Warping Time Series Join (WTSJ) algorithm. The filtering step serves to prune those sparse regions of the e-matching matrix where there are no maximal l-connections without incurring costly computation. The refinement step serves to detect closed l-connections within regions that cannot be pruned by the filtering step. To speed up the computation of e-matching matrix, we propose a block-based time series summarization method, based on which the block-wise e-matching matrix is first computed. Lots of pairwise distance computation of elements can then be avoided by applying the filtering algorithm on the block-wise e-matching matrix.Extensive experiments on l-e-join of motion capture sequences are conducted. The results confirm the efficiency and effectiveness of our proposed algorithm in processing l-e-join of motion capture time series.
116588251
On-line evolutionary exponential family mixture
This paper deals with evolutionary clustering, which refers to the problem of clustering data with distribution drifting along time. Starting from a density estimation view to clustering problems, we propose two general on-line frameworks. In the first framework, i.e., historical data dependent (HDD), current model distribution is designed to approximate both current and historical data distributions. In the second framework, i.e., historical model dependent (HMD), current model distribution is designed to approximate both current data distribution and historical model distribution. Both frameworks are based on the general exponential family mixture (EFM) model. As a result, all conventional clustering algorithms based on EFMs can be extended to evolutionary setting under the two frameworks. Empirical results validate the two frameworks.
8051159
A Web-based Framework For On-line Collaborative Learning
This paper presents a framework for design of online courses and collaborative learning based on Web technologies. It provides the following features: construction of structured learning materials in a distributed environment; personalization of course contents in the run-time that adapts to the progress of individual students; it can supply relevant Web resources to the students by analyzing the learning history dynamically; students in a group could exchange their learning experiences and discover relevant knowledge via the communication channels provided by the framework. The proposed techniques could be deployed to a variety of online computer-assisted modules to improve the effectiveness of Web-based e-learning
11514442
A test pattern ordering algorithm for diagnosis with truncated fail data
In this paper, we propose a test pattern ordering algorithm for fault diagnosis. Test pattern ordering is effective in situations where the fail log is truncated and contains a limited number of fail data. In such cases, higher diagnostic resolution can be achieved with the test set appropriately ordered. Test pattern ordering is independent of the diagnosis algorithm used. The higher resolution achieved by test pattern ordering is obtained at no additional cost once the test patterns have been appropriately ordered. Experimental results on two industrial designs are presented to demonstrate the effectiveness of the proposed method
2501005
Coordinating Multiple Agents via Reinforcement Learning
In this paper, we attempt to use reinforcement learning techniques to solve agent coordination problems in task-oriented environments. The Fuzzy Subjective Task Structure model (FSTS) is presented to model the general agent coordination. We show that an agent coordination problem modeled in FSTS is a Decision-Theoretic Planning (DTP) problem, to which reinforcement learning can be applied. Two learning algorithms, ‘‘coarse-grained’’ and ‘‘fine-grained’’, are proposed to address agents coordination behavior at two different levels. The ‘‘coarse-grained’’ algorithm operates at one level and tackle hard system constraints, and the ‘‘fine-grained’’ at another level and for soft constraints. We argue that it is important to explicitly model and explore coordination-specific (particularly system constraints) information, which underpins the two algorithms and attributes to the effectiveness of the algorithms. The algorithms are formally proved to converge and experimentally shown to be effective.
37994970
Image coding quality assessment using fuzzy integrals with a three-component image model
Based on importance measures and fuzzy integrals, a new assessment method for image coding quality is presented in this paper. The proposed assessment is based on two subevaluations. In the first subevaluation, errors on edges, textures, and flat regions are computed individually. The errors are then assessed using an assessment function. A global evaluation with Sugeno fuzzy integral is then obtained based on the importance measure of edge, texture, and flat region. In the second subevaluation, an importance measure is first established depending on the types of regions where errors occur, a subtle evaluation is then obtained using Sugeno fuzzy integral on all pixels of the image. A final evaluation is obtained based on the two subevaluations. Experimental results show that this new image quality assessment closely approximates human subjective tests such as mean opinion score with a high correlation coefficient of 0.963, which is a significant improvement over peak signal-to-noise ratio, picture quality scale, and weighted mean square error, three other image coding quality assessment methods, which have the correlation coefficients of 0.821, 0.875, and 0.716, respectively.
34190440
Coercive subtyping for the calculus of constructions
13922126
Scene Simulation Platform Based on Data Fusion of Multiple Format 3D Models
Scene simulation technology has been the basal component for building 3D simulation application now. Constructing a general scene simulation platform based on multiple format 3D models can greatly speed developing process of simulation application and promote developing efficiency. According to the idea above, a method of building scene simulation platform based on models data fusion is put forward. With this method, multiple 3D model data format such as FLT, 3DS, X, WRL and GLS are fused and driven by OpenGL API. The layered structure and framework based on HLA are also presented to design the platform. Key technologies involving model data fusion and simulation driving are detailed. Finally, challenges associating with realization of the platform named plug-in framework and simulation examples based on the platform are brought forward. It shows greatest traits on building similar large-scale simulation application system.