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The Architecture and Applications of the Apollo Domain
The Domain system's objective is to integrate mainframe capability with local area networking and raster graphics capabilities at a cost appropriate to engineering and graphics applications.
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Professional Workstations (Panel Session)
Andries van Dam The panel will examine the evolution of the professional workstation from a time shared terminal to powerful graphics-based personal computer connected to a resource-sharing local n...
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Coursework in cognition by mathematics undergraduates: a seven year review
ABSTRACT In recent times it has become increasingly possible for mathematics students to include a limited number of approved optional non-specialist modules in their degree programs in the UK. These courses may offer opportunities for essay writing or experimental project work which are not generally available to students confined to specialist mathematics modules. Many staff believe the availability of such opportunities to be a valuable component of a degree program. This article surveys such coursework in four such non-specialist modules over a seven-year period and, in particular, examines work in the area of mathematical cognition.
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Automated semantic analysis of design models
Based on several years of experience in generating code from large SDL and UML models in the telecommunications domain, it has become apparent that model analysis must be used to augment more traditional validation and testing techniques. While model correctness is extremely important, the difficulty of use and non-scalability of most formal verification techniques when applied to large-scale design models renders them insufficient for most applications. We have also repeatedly seen that even the most complete test coverage fails to find many problems. In contrast, sophisticated model analysis techniques can be applied without human interaction to large-scale models. A discussion of the model analysis techniques and the model defects that they can detect is provided, along with some real-world examples of defects that have been caught.
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Mobile 3D Game Development: From Start to Market
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SIGGRAPH public policy committee activity detailed
We start this column with the results of our third on-line opinion survey on public policy issues affecting computer graphics. Next we provide an introduction to and a copy of the definition paper for a prospective study of computer graphics research to be conducted by the National Research Council with partial funding from SIGGRAPH. This is followed by an update on our activities in proposing a course on public policy and a panel on digital rights management of intellectual property for SIGGRAPH 2001. Myles Losch provides an update on the issues related to the slow pace of adoption of Digital TV. Finally, we close with another set of comments from a reader.
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High-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID)
BackgroundWe previously developed GoMiner, an application that organizes lists of 'interesting' genes (for example, under-and overexpressed genes from a microarray experiment) for biological interpretation in the context of the Gene Ontology. The original version of GoMiner was oriented toward visualization and interpretation of the results from a single microarray (or other high-throughput experimental platform), using a graphical user interface. Although that version can be used to examine the results from a number of microarrays one at a time, that is a rather tedious task, and original GoMiner includes no apparatus for obtaining a global picture of results from an experiment that consists of multiple microarrays. We wanted to provide a computational resource that automates the analysis of multiple microarrays and then integrates the results across all of them in useful exportable output files and visualizations.ResultsWe now introduce a new tool, High-Throughput GoMiner, that has those capabilities and a number of others: It (i) efficiently performs the computationally-intensive task of automated batch processing of an arbitrary number of microarrays, (ii) produces a human-or computer-readable report that rank-orders the multiple microarray results according to the number of significant GO categories, (iii) integrates the multiple microarray results by providing organized, global clustered image map visualizations of the relationships of significant GO categories, (iv) provides a fast form of 'false discovery rate' multiple comparisons calculation, and (v) provides annotations and visualizations for relating transcription factor binding sites to genes and GO categories.ConclusionHigh-Throughput GoMiner achieves the desired goal of providing a computational resource that automates the analysis of multiple microarrays and integrates results across all of the microarrays. For illustration, we show an application of this new tool to the interpretation of altered gene expression patterns in Common Variable Immune Deficiency (CVID). High-Throughput GoMiner will be useful in a wide range of applications, including the study of time-courses, evaluation of multiple drug treatments, comparison of multiple gene knock-outs or knock-downs, and screening of large numbers of chemical derivatives generated from a promising lead compound.