sentence2_structure: Smoking<>tobaccowould most likely have<>a negative impact on the ability of an individual$$$it<>decreases<>stamina and cardiovascular efficiency
sentence1: In addition, by inhibiting CYP2A6, smoking can be decreased in tobacco-dependent individuals.
sentence2: Smoking tobaccowould  most likely have a negative impact on the ability of an individual to succeed at physical activities because it it decreases stamina and cardiovascular efficiency.
question: How would smoking tobacco most likely have a negative impact on the ability of an individual to succeed at physical activities?