( Furthermore ( , ( caution ( ( should ( be ( exercised ( when ( ( combining digoxin ) ( with ( ( any drug ) ( that ( may ( ( ( ( cause ( a ( significant deterioration ) ) ) ( in ( renal function ) ) ) , ) ( since ( ( ( a decline ) ( in ( ( ( glomerular filtration ) or ) ( tubular secretion ) ) ) ) ( may ( impair ( ( the excretion ) ( of digoxin ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) . ) ) ) )
(ROOT (S (ADVP (RB Furthermore)) (, ,) (NP (NN caution)) (VP (MD should) (VP (VB be) (VP (VBN exercised) (SBAR (WHADVP (WRB when)) (S (VP (VBG combining) (NP (NN digoxin)) (PP (IN with) (NP (NP (DT any) (NN drug)) (SBAR (WHNP (WDT that)) (S (VP (MD may) (VP (VB cause) (NP (DT a) (JJ significant) (NN deterioration)) (PP (IN in) (NP (JJ renal) (NN function))) (, ,) (SBAR (IN since) (S (NP (NP (DT a) (NN decline)) (PP (IN in) (NP (NP (NN glomerular) (NN filtration)) (CC or) (NP (JJ tubular) (NN secretion))))) (VP (MD may) (VP (VB impair) (NP (NP (DT the) (NN excretion)) (PP (IN of) (NP (NN digoxin)))))))))))))))))))) (. .)))
Furthermore, caution should be exercised when combining digoxin with any drug that may cause a significant deterioration in renal function, since a decline in glomerular filtration or tubular secretion may impair the excretion of digoxin.
(ROOT (S (NP (NP (DT The) (JJ main) (NNS functions)) (PP (IN of) (NP (NN epithelia)))) (VP (VBP are) (NP (NP (NN protection)) (PP (IN from) (NP (NP (DT the) (NN environment) (, ,) (NN coverage) (, ,) (NN secretion) (CC and) (NN excretion)) (, ,) (NP (NN absorption)) (, ,) (CC and) (NP (NN filtration)))))) (. .)))