( ( ( ( ( Most ( changes ( to ( the ( estrogen ( structure cause ) ) ) ) ) ) ( ( a loss ) ( of activity ) ) ) , ) ( such ( as ( conversion ( at ( ( position 3 ) of ) ) ) ) ) ) - )
(ROOT (NP (NP (JJS Most)) (NP (NP (NNS changes)) (PP (TO to) (NP (DT the) (NN estrogen) (NN structure) (NN cause)))) (NP (NP (DT a) (NN loss)) (PP (IN of) (NP (NN activity)))) (, ,) (PP (JJ such) (IN as) (NP (NP (NN conversion)) (PP (IN at) (NP (NP (NN position) (CD 3)) (PP (IN of)))))) (: -)))
Most changes to the estrogen structure cause a loss of activity, such as conversion at position 3 of -
(ROOT (S (NP (NNP Estrogen)) (VP (VBZ causes) (NP (NP (DT the) (NNS changes)) (PP (IN of) (NP (NN puberty))))) (. .)))