( ( In ( addition ( to ( D-type ( cyclin-cdk complexes ) ) ) ) ) ( , ( ( cyclin E-cdk2 ) ( ( ( has also ) ( been ( ( implicated ( in ( ( the regulation ) ( of ( cell ( cycle progression ) ) ) ) ) ) ( through ( the ( G ( 1 phase ) ) ) ) ) ) ) . ) ) ) )
(ROOT (S (PP (IN In) (NP (NP (NN addition)) (PP (TO to) (NP (JJ D-type) (JJ cyclin-cdk) (NNS complexes))))) (, ,) (NP (NN cyclin) (NNS E-cdk2)) (VP (VBZ has) (ADVP (RB also)) (VP (VBN been) (VP (VBN implicated) (PP (IN in) (NP (NP (DT the) (NN regulation)) (PP (IN of) (NP (NN cell) (NN cycle) (NN progression))))) (PP (IN through) (NP (DT the) (NNP G) (CD 1) (NN phase)))))) (. .)))
In addition to D-type cyclin-cdk complexes, cyclin E-cdk2 has also been implicated in the regulation of cell cycle progression through the G 1 phase.
(ROOT (S (NP (NNS Cyclins)) (VP (VB regulate) (NP (DT the) (NN cell) (NN cycle)) (ADVP (RB only)) (SBAR (WHADVP (WRB when)) (S (NP (PRP they)) (VP (VBP are) (ADJP (RB tightly) (VBN bound) (PP (TO to) (NP (NNS cdks)))))))) (. .)))