( ( ( This ( catalytic reaction ) ) ( of selenium ) ) ( ( ( compounds ( with ( ( ( thiols likely ) accounts ) ( for ( selenium toxicity ) ) ) ) ) ( ( ( to ( cells ( ex vivo ) ) ) and ) ( in ( vivo ( where ( ( ( ( ( the ( major ( glutathione ( producing organ ) ) ) ) , ) ( the liver ) ) , ) ( ( is also ) ( ( the ( major ( target organ ) ) ) ( of ( selenium toxicity ) ) ) ) ) ) ) ) ) ) . ) )
(ROOT (S (NP (NP (DT This) (JJ catalytic) (NN reaction)) (PP (IN of) (NP (NN selenium)))) (VP (VBZ compounds) (PP (IN with) (NP (NP (ADJP (JJ thiols) (JJ likely)) (NNS accounts)) (PP (IN for) (NP (NN selenium) (NN toxicity))))) (PP (PP (TO to) (NP (NNP cells) (FW ex) (NNP vivo))) (CC and) (PP (IN in) (NP (NP (NN vivo)) (SBAR (WHADVP (WRB where)) (S (NP (NP (DT the) (JJ major) (NN glutathione) (VBG producing) (NN organ)) (, ,) (NP (DT the) (NN liver)) (, ,)) (VP (VBZ is) (ADVP (RB also)) (NP (NP (DT the) (JJ major) (NN target) (NN organ)) (PP (IN of) (NP (NN selenium) (NN toxicity))))))))))) (. .)))
This catalytic reaction of selenium compounds with thiols likely accounts for selenium toxicity to cells ex vivo and in vivo where the major glutathione producing organ, the liver, is also the major target organ of selenium toxicity.
(ROOT (S (NP (NNP Glutathione)) (VP (VBZ is) (NP (NP (DT a) (JJ low-molecular-weight) (NN compound)) (VP (VBN found) (PP (IN in) (NP (VBG living) (NNS cells)))) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (VP (VBN produced) (ADVP (RB naturally)) (PP (IN by) (NP (DT the) (NN liver))))))))) (. .)))