( ( In ( secretory ( proteins ( and ( type ( I ( transmembrane proteins ) ) ) ) ) ) ) ( , ( ( the ( signal sequence ) ) ( ( ( is immediately ) ( ( cleaved ( from ( the ( nascent polypeptide ) ) ) ) ( once ( it ( has ( been ( ( translocated ( into ( ( the membrane ) ( of ( ( ( ( ( the ER ) ( -LRB- ( eukaryotes -RRB- ) ) ) or ) ( plasma membrane ) ) ( -LRB- ( prokaryotes -RRB- ) ) ) ) ) ) ) ( by ( signal peptidase ) ) ) ) ) ) ) ) ) . ) ) ) )
(ROOT (S (PP (IN In) (NP (JJ secretory) (NNS proteins) (CC and) (NN type) (NN I) (JJ transmembrane) (NNS proteins))) (, ,) (NP (DT the) (NN signal) (NN sequence)) (VP (VBZ is) (ADVP (RB immediately)) (VP (VBN cleaved) (PP (IN from) (NP (DT the) (JJ nascent) (NN polypeptide))) (SBAR (IN once) (S (NP (PRP it)) (VP (VBZ has) (VP (VBN been) (VP (VBN translocated) (PP (IN into) (NP (NP (DT the) (NN membrane)) (PP (IN of) (NP (NP (DT the) (NNP ER)) (PRN (-LRB- -LRB-) (NP (NNS eukaryotes)) (-RRB- -RRB-)) (CC or) (NP (NN plasma) (NNS membrane)) (PRN (-LRB- -LRB-) (NP (NNS prokaryotes)) (-RRB- -RRB-)))))) (PP (IN by) (NP (NN signal) (NN peptidase)))))))))) (. .)))
In secretory proteins and type I transmembrane proteins, the signal sequence is immediately cleaved from the nascent polypeptide once it has been translocated into the membrane of the ER (eukaryotes) or plasma membrane (prokaryotes) by signal peptidase.
(ROOT (S (NP (JJ Transmembrane) (NNS proteins)) (VP (VBP span) (NP (DT the) (JJ entire) (NN plasma) (NN membrane))) (. .)))