( However ( , ( ( in ( ( the ( early application ) ) ( of ( thermodynamics ( to ( chemical reactions ) ) ) ) ) ) ( , ( this ( ( ( was not ) known ) . ) ) ) ) ) )
(ROOT (S (ADVP (RB However)) (, ,) (PP (IN in) (NP (NP (DT the) (JJ early) (NN application)) (PP (IN of) (NP (NP (NNS thermodynamics)) (PP (TO to) (NP (NN chemical) (NNS reactions))))))) (, ,) (NP (DT this)) (VP (VBD was) (RB not) (VP (VBN known))) (. .)))
However, in the early application of thermodynamics to chemical reactions, this was not known.
(ROOT (S (NP (NNP Chemical) (NNS reactions)) (VP (VBP follow) (NP (NP (DT the) (NNS laws)) (PP (IN of) (NP (NNS thermodynamics))))) (. .)))