( ( Once again ) ( ( Wnt proteins ) ( ( binds ( to ( ( ( ( and ( activates Frizzled ) ) ( so ( that ( Frizzled ( activates ( ( a ( Dishevelled protein ) ) ( that ( is ( tethered ( to ( ( the plasma ) ( membrane ( through ( a ( Prickle protein ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) and ) ( transmembrane ( Stbm protein ) ) ) ) ) . ) ) )
(ROOT (S (ADVP (RB Once) (RB again)) (NP (NNP Wnt) (NNS proteins)) (VP (VBZ binds) (S (VP (TO to) (VP (VP (VB and) (NP (NNP activates) (NNP Frizzled)) (SBAR (RB so) (IN that) (S (NP (NNP Frizzled)) (VP (VBZ activates) (NP (NP (DT a) (NNP Dishevelled) (NN protein)) (SBAR (WHNP (WDT that)) (S (VP (VBZ is) (ADJP (JJ tethered) (PP (TO to) (NP (NP (DT the) (NN plasma)) (VP (VBN membrane) (PP (IN through) (NP (DT a) (NNP Prickle) (NN protein))))))))))))))) (CC and) (VP (VB transmembrane) (NP (NNP Stbm) (NN protein))))))) (. .)))
Once again Wnt proteins binds to and activates Frizzled so that Frizzled activates a Dishevelled protein that is tethered to the plasma membrane through a Prickle protein and transmembrane Stbm protein.
(ROOT (S (NP (JJ Transmembrane) (NNS proteins)) (VP (VBP span) (NP (DT the) (JJ entire) (NN plasma) (NN membrane))) (. .)))