( ( ( ( ( Many proteins ) , ) ( including antibodies ) ) , ) ( ( are ( difficult ( to ( ( express ( in ( host cells ) ) ) ( due ( to ( problems ( with ( insolubility ( , ( disulfide ( bonds ( or ( host ( cell toxicity ) ) ) ) ) ) ) ) ) ) ) ) ) ) ) . ) )
(ROOT (S (NP (NP (JJ Many) (NNS proteins)) (, ,) (PP (VBG including) (NP (NNS antibodies))) (, ,)) (VP (VBP are) (ADJP (JJ difficult) (S (VP (TO to) (VP (VB express) (PP (IN in) (NP (NN host) (NNS cells))) (PP (JJ due) (TO to) (NP (NP (NNS problems)) (PP (IN with) (NP (NN insolubility) (, ,) (NN disulfide) (NNS bonds) (CC or) (NN host) (NN cell) (NN toxicity)))))))))) (. .)))
Many proteins, including antibodies, are difficult to express in host cells due to problems with insolubility, disulfide bonds or host cell toxicity.
(ROOT (S (NP (NNS Antibodies)) (VP (VBP recognize) (CC and) (VBP combine) (PP (IN with) (NP (JJ harmful) (NNS materials))) (, ,) (PP (VBG including) (NP (NP (DT both) (JJ toxic) (NNS chemicals)) (CC and) (NP (JJ invasive) (NNS microorganisms))))) (. .)))