( ( ( 5.3.1.5 Inhibition ) ( of ( ( DNA synthesis ) ( in ( ( Chinese ( hamster ( ovary ( ( -LRB- ( CHO -RRB- ) ) cells ) ) ) ) ( Powdered nickel ) ) ) ) ) ) ( ( ( ( blocked progression ) ( through ( ( S phase ) ( of ( ( ( the ( cell cycle ) ) ( -LRB- ( ( DNA replication ) -RRB- ) ) ) ( in ( cultured ( CHO cells ) ) ) ) ) ) ) ) ( in ( a ( flow ( cytometric ( assay ( -LRB- ( Costa ( et al. ) ) ) ) ) ) ) ) ) . ) )
(ROOT (S (NP (NP (CD 5.3.1.5) (NN Inhibition)) (PP (IN of) (NP (NP (NNP DNA) (NNP synthesis)) (PP (IN in) (NP (NP (JJ Chinese) (NN hamster) (NN ovary) (PRN (-LRB- -LRB-) (NP (NNP CHO)) (-RRB- -RRB-)) (NNS cells)) (NP (NN Powdered) (NN nickel))))))) (VP (VBD blocked) (NP (NN progression)) (PP (IN through) (NP (NP (NNP S) (NN phase)) (PP (IN of) (NP (NP (NP (DT the) (NN cell) (NN cycle)) (PRN (-LRB- -LRB-) (NP (NNP DNA) (NN replication)) (-RRB- -RRB-))) (PP (IN in) (NP (JJ cultured) (NNP CHO) (NNS cells))))))) (PP (IN in) (NP (DT a) (NNP flow) (JJ cytometric) (JJ assay) (-LRB- -LRB-) (NNP Costa) (FW et) (NN al.)))) (. .)))
5.3.1.5 Inhibition of DNA synthesis in Chinese hamster ovary (CHO) cells Powdered nickel blocked progression through S phase of the cell cycle (DNA replication) in cultured CHO cells in a flow cytometric assay (Costa et al.
(ROOT (S (PP (IN During) (NP (DT the) (NN synthesis) (NN phase))) (, ,) (NP (NN dna) (NN replication)) (VP (VBZ occurs) (PP (IN in) (NP (DT the) (NN cell) (NN cycle)))) (. .)))
During the synthesis phase, dna replication occurs in the cell cycle.