( ( ( ( ( ( ( Both ( the ( dominant ( and ( recessive mutations ) ) ) ) ) ( of ( ( mel-26 result ) ( in ( mei-1 protein ) ) ) ) ) ( ectopically ( localized ( in ( mitotic ( ( spindles and ) centrosomes ) ) ) ) ) ) , ) leading ) ( to ( ( ( small and ) misoriented ) ( cleavage spindles ) ) ) ) . )
(ROOT (NP (NP (NP (PDT Both) (DT the) (JJ dominant) (CC and) (JJ recessive) (NNS mutations)) (PP (IN of) (NP (NP (JJ mel-26) (NN result)) (PP (IN in) (NP (JJ mei-1) (NN protein)))))) (ADJP (RB ectopically) (JJ localized) (PP (IN in) (NP (JJ mitotic) (NNS spindles) (CC and) (NNS centrosomes)))) (, ,) (VP (VBG leading)) (PP (TO to) (NP (ADJP (JJ small) (CC and) (JJ misoriented)) (NN cleavage) (NNS spindles))) (. .)))
Both the dominant and recessive mutations of mel-26 result in mei-1 protein ectopically localized in mitotic spindles and centrosomes, leading to small and misoriented cleavage spindles.
(ROOT (S (NP (DT A) (JJ mitotic) (NN spindle)) (VP (VBZ forms) (PP (IN from) (NP (DT the) (NNS centrosomes)))) (. .)))
A mitotic spindle forms from the centrosomes.