THE Tasmanian tiger has been extinct for more than 80 years — but that could be about to change.

Once considered a fanciful idea, it is now plausible that we’ll see the resurrection of certain extinct species. Continual advances in science, particularly in the field of genetics, means that we are getting ever closer to bringing the iconic Australian marsupial, and others, back to life.

Andrew Pask, a biologist from the University of Melbourne, was part of a team who worked for 10 years to successfully sequence the entire genome of a Tasmanian tiger, also known as a thylacine, with the help of a four-week-old joey preserved in a different solution to other damaged specimens.

Prof Pask referred to the preserved joey as the “the Holy Grail” specimen and allowed researchers to piece together the full picture of the marsupial’s “genetic blueprint”.

The researchers completed the genome sequencing in December last year, gaining fresh insight about the animal.

“It gave us so much information about what was unique about the thylacine. We learned more about its biology, we learned about its population structure over time, we also learned more about where it sits and how it related (biologically) to other marsupials” he said.

“It was a very, very unique marsupial species. The last one of its kind.”

That uniqueness is exactly why we might want to bring it back to life — but it’s a quality that also makes the process extra difficult.

Rapid advancements in technology are opening up the possibility of resurrecting certain species — or at least re-engineering something that looks close enough.

In particular, a cloning technique pioneered by Harvard geneticist George Church which is not too dissimilar to that imagined in Jurassic Park is at the forefront of the de-extinction movement.

His team is working to bring back the mammoth by using the DNA of its closest living relative, the Asian elephant, to essentially fill in the gaps of the mammoth DNA.

“That’s something that’s not science fiction any more, it’s science fact,” Prof Pask said. “They will be able to bring something mammoth-like back to life.” And it could one day open the floodgates for resurrecting other lost species.

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“The thing with the mammoth is, there is a very closely related living species around still — the elephant — which makes the task much easier,” Prof Pask said.

“What you have to do is take that elephant DNA and make all the changes you see in the mammoth genome on the elephant’s genetic blueprint. Basically you’re just editing the (elephant) DNA to make it look like a mammoth.”

The fewer changes you have to make, the easier it is.

However when it comes to the thylacine, there’s nothing really that closely related any more. The closest living relative is the numbat but it’s still quite different.

“You would have to make a lot more changes to make the numbat DNA look like a thylacine but the technology for making those changes has gotten exponentially easier in the last five or so years because of the people who are doing the mammoth work,” Prof Pask said.

It’s foreseeable as the technology improves, it would be able to be applied to bringing back the thylacine. Or, more accurately, a numbat/thylacine hybrid which takes on the appearance and attributes of a Tasmanian tiger.

The major development in this field has been the advent of CRISPR-Cas9 which is essentially a tool being used by genetic engineers to introduce enzymes that are used by bacteria to target and destroy foreign DNA.

CRISPR has been referred to as a kind of “molecular scissors” that allow scientists to easily, and more cheaply, edit DNA.

“That’s really the major advancement,” Prof Pask said.

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However CRISPR technology is still in its infancy and has only been used by scientists to edit genes for the past five years or so. Because tweaking the DNA of a numbat to produce something closer to a thylacine would require about 10 times the changes compared to the elephant/mammoth project, advancements in our understanding of the technology and DNA itself would be required before scientists set about trying to bring back the thylacine.

At this point, researchers will be waiting to see the long-term results of the mammoth project before they start applying the same technique to other extinct animals.

“We’ll wait and see what it looks like, how it behaves and all of those things and whether we could apply that same technology,” Prof Pask said.

But if it does come to pass, our continent could once again be host to one of Australia’s most iconic lost species.

The thylacine vanished from the Australian mainland about 3000 years ago. A thylacine population survived in Tasmania long after the demise of their mainland cousins, but a bounty was placed on their heads in the 19th century because they were believed to be responsible for sheep deaths.

The population went into rapid decline. The Tasmanian government introduced official protection for the species in 1936, but came too late. Just two months later, the last known thylacine died in captivity.

Searches for the thylacine have continued ever since, with some enthusiasts adamant they have seen living tigers in recent decades, but of course any proof has been lacking.</s>The extinct Tasmanian tiger is set to be resurrected by Australian scientists who plan to clone the species.

Thanks to continual advances in modern technology, scientists are closer than ever to bringing the iconic Australian marsupial, as well as other species, back to life, the Daily Telegraph reported.

Andrew Pask, a biologist from the University of Melbourne, was part of a team who successfully sequenced the genome of a Tasmanian tiger, known as a thylacine last year.

The specimen of a four week old joey allowed experts to piece together the marsupial's 'genetic blueprint'.

'It gave us so much information about what was unique about the thylacine.

We learned more about its biology, we learned about its population structure over time, we also learned more about where it sits and how it related to other marsupials' he said.

A cloning technique developed by Harvard geneticist George Church is leading the way in de-extinction.

Church's team are working to bring back the mammoth by using DNA of an Asian elephant (its closest living relative).

'That's something that's not science fiction any more, it's science fact. They will be able to bring something mammoth-like back to life,' Professor Andrew Pask said.

The closest living relative to the thylacine, is the numbat, but there are many differences in the two species.

'You would have to make a lot more changes to make the numbat DNA look like a thylacine but the technology for making those changes has gotten exponentially easier in the last five or so years because of the people who are doing the mammoth work,' Professor Pask said.

The Tasmanian Tiger officially became extinct in 1986, despite the death of the last known thylacine in Hobart Zoo in 1936.</s>The exhibition explores Melbourne’s fertile electronic music scene from 1969-1974 and, more broadly, the evolution of the commercially produced synthesizer by EMS (Electronic Music Studios Ltd.).

The Grainger Museum was at the heart of musical experimentation in Melbourne in the late 1960s, when composer and teacher Keith Humble returned from Paris brimming with avant-garde ideas to establish a renegade composition studio at the Grainger using early synthesizers.

A collaboration between the Grainger and Melbourne Electronic Sound Studio (MESS) – one of the most historically significant collections of electronic instruments in the world – the exhibition features key instruments on loan from MESS and the Museum of Applied Arts and Sciences, including the ultra rare EMS VCS-1 – one of three in the world – an EMS VCS-3 – used by Pink Floyd, Brian Eno and Jean-Michel Jarre – an EMS Spectre video synth and the cutting edge video art it produced (including electronic artist David Chesworth’s 50 Synthesizer Greats). You can check out David’s Cyclic Selects here.

Synthesizers: Sound of the Future

 Grainger Museum, University of Melbourne

 20 April – 9 September 2018

 Free Entry

You can find out more here.

And if you’re not in Melbourne you can view the exhibition here.
Biologists at the University of Melbourne announce plans to clone the extinct thylacine (Tasmanian tiger).