Singapore has so far detected more than 280 Zika infections since reporting its first case on Aug. 27.

Zika infections in pregnant women have been shown to cause microcephaly - a severe birth defect in which the head and brain are undersized - as well as other brain abnormalities. The connection between Zika and microcephaly first came to light last fall in Brazil, which has since confirmed more than 1,800 cases of the birth defect.

In adults, Zika infections have also been linked to a rare neurological syndrome known as Guillain-Barre, as well as other neurological disorders.

An analysis of two locally infected patients showed the Zika strain in Singapore likely evolved from a strain already circulating in Southeast Asia since the 1960s, the Straits Times newspaper said on its website.

The analysis will be made available for the benefit of the global scientific community, including the World Health Organization (WHO), the newspaper said.

On Wednesday, the WHO updated its assessment of the Zika virus as a cause of congenital brain abnormalities in babies and the Guillian-Barre syndrome, after considering months of research into the mosquito-borne disease. </s> Zika infections are expected to continue rising in the Asia-Pacific region, where authorities are increasing surveillance, preparing responses to complications and collaborating on information about the disease, the World Health Organization said Monday.

Complicating the fight against the virus, spread by mosquitoes, is the lack of a "foolproof" approach to mosquito control, as shown by decades of efforts to contain dengue virus, WHO Director General Margaret Chan said in her address to a Western Pacific regional meeting of the world health body.

She said other questions included why the first signs of the virus's existence in the Asia-Pacific region came from travelers whose infections were confirmed once they returned home.

"Is this weak surveillance an indication of population-wide immunity, or proof that the virus has somehow acquired greater epidemic potential?" she asked.

Zika symptoms are mild and no deaths have been reported globally, said Dr. Li Ailan, director for health security and emergencies at WHO's Western Pacific regional office. But she said based on WHO's risk assessment, Zika viral infection will continue to spread in the region and authorities are preparing for complications.

The complications include like microcephaly and Guillain-Barre syndrome. Babies born to Zika-infected mothers have been found to have microcephaly, or a birth defect where the head is abnormally small and brains might not have developed properly. Guillain-Barre syndrome is a disorder in which the body's immune system attacks part of the peripheral nervous system.

The Western Pacific region is the second most Zika-affected region in the world, Li said. Nineteen of its 27 countries have reported Zika cases since 2007 and 13 of them this year.

Dr. Shin Young-soo, WHO's Western Pacific regional head, said they are working very hard to increase surveillance and detection of Zika, and long-term response to the disease are among the topics to be discussed at the five-day conference. Those include detecting cases and reducing mosquito density, especially in high-risk locations, Dr. Li said.
The Ministry of Health of Peru reports that so far this year, 548 people have contracted Guillain–Barré syndrome in an outbreak in the country. It also clarified that in the five cases in which patients died, death was caused by complications with other serious diseases.