6-(3,3-Dimethyl-2-methylideneindol-1-yl)hexanoic acid;hydrobromide
Hyaluronidase is an enzyme used to improve the absorption and dispersion of parenterally administered fluids, drugs, and contrast agents. The action of hyaluronidase was first described in 1936, and named in 1939. Early research into hyaluronidase identified it as a "spreading factor" which allowed for increased permeability of the connective tissue. Hyaluronidase has been used in surgical settings for at least the past 60 years to improve the diffusion of local anesthetics.  Hyaluronidase was first used in prescription products in the United States on 5 May 2004.