Clodronic Acid
Clodronic acid is a first generation bisphosphonate similar to [etidronic acid] and [tiludronic acid]. These drugs were developed to mimic the action of pyrophosphate, a regulator of calcification and decalcification. clodronate’s use has decreased over the years in favor of the third generation, nitrogen containing bisphosphonate [zoledronic acid], [ibandronic acid], [minodronic acid], and [risedronic acid].  Clodronic acid is not FDA approved, but is approved in Canada.