2-(8-Hydroxy-6-methoxy-1-oxo-1H-isochromen-3-yl)propionic acid
Isocoumarin NM-3 is an orally bioavailable antiangiogenic isocoumarin with potential antineoplastic activity.  NM-3 inhibits vascular endothelial growth factor (VEGF), a pro-angiogenic growth factor, thereby inhibiting endothelial cell proliferation.  This agent also induces apoptosis by a mechanism involving reactive oxygen species. (NCI04)