text: By Kathleen Doheny 
   
   HealthDay Reporter 
   
   WEDNESDAY, Aug. 28 (HealthDay News) -- Drinking even one alcoholic drink a day in the years before a woman's first pregnancy can increase her risk of breast cancer later in life, according to a large new study. 
   
   Other research has linked alcohol consumption to increased breast cancer risk, as well as finding that delayed childbearing can increase breast cancer risk. 
   
   The new research is thought to be the first to focus on the effect of alcohol intake during the time frame between the start of menstruation and a first pregnancy, the researchers said. 
   
   "The risk increased by 11 percent for every 10 grams a day of intake, about six drinks per week," said study author Dr. Ying Liu, an instructor of public health sciences at Washington University School of Medicine, in St. Louis. "These risk values were estimated as compared with nondrinkers." 
   
   "One drink was defined as one bottle or can of beer, a 4-ounce glass of wine or a shot of liquor," Liu said. 
   
   Drinking about one drink a day also increased the risk for proliferative benign breast disease, a risk factor for breast cancer, by about 16 percent, according to the study, which was published Aug. 28 in the Journal of the National Cancer Institute. 
   
   The researchers analyzed data from more than 91,000 women who took part in the Nurses' Health Study II who had no cancer history when they began. They answered questions on alcohol consumption in 1989 and were followed through 2009 to analyze their risk of breast cancer. 
   
   The new study also looked at whether the women contracted benign breast disease, and whether alcohol may have played a role in that condition, in a subgroup of more than 60,000 women who were evaluated from 1991 through 2001. 
   
   The researchers found more than 1,600 cases of breast cancer and 970 diagnoses of benign breast disease during the study period. 
   
   Drinking alcohol after the first menstrual period and before the first pregnancy was linked with a risk of both, regardless of whether a woman drank after the first pregnancy. The link held after accounting for multiple other risk factors, including family history of breast cancer. 
   
   The more the women drank, the higher their risk. 
   
   The researchers, however, found only a link between pre-pregnancy drinking and breast cancer risk, not a cause-and-effect relationship. 
   
   "Breast tissues are particularly susceptible to environmental exposures between [the onset of menstruation] and first pregnancy because they undergo rapid cellular proliferation," Liu said. During pregnancy, however, other cellular changes make the breast tissue less susceptible to cancer. 
   
   "Our results suggest that alcohol intake before the first pregnancy consistently increases the risk of breast cancer and the risk of proliferative [benign breast disease]," Liu said. She speculated that the benign breast disease may be a pathway linking drinking in early life and breast cancer, ''but not the only route." 
   
   It is crucial to put the 11 percent increased risk in perspective, said Dr. Laura Kruper, co-director of the breast cancer program and director of the Cooper Finkel Women's Health Center at the City of Hope Cancer Center in Duarte, Calif. 
   
   Overall, a woman's lifetime risk of breast cancer is about one in eight, or 12 percent. "If you take the baseline risk -- 12 percent -- and increase that by 11 percent, it is about 13 percent," Kruper said. 
   
   Liu said the one-in-eight statistic includes both drinkers and nondrinkers, but she did not know of a statistic for lifetime breast cancer risk for nondrinkers. 
   
   So although the study did find an increased risk, Kruper said, "I think the real take-home point is the more you drink the more you increase risk." 
   
   The research is another call for moderation, Kruper and Liu agreed. Liu said all women in the age category she studied "should reduce their drinking to less than one drink a day, especially before first pregnancy, to reduce their breast cancer risk." 
   
   More information 
   
   To learn more about risk factors for breast cancer, visit the American Cancer Society. 
   
   Copyright © 2012 HealthDay. All rights reserved. ||||| Drinking alcohol before first pregnancy is associated with an increased risk of benign breast disease (BBD) and breast cancer, independent of drinking after first pregnancy, according to a new study published August 28 in the Journal of the National Cancer Institute. 
   
   Previous studies have shown that alcohol consumed in the past year affects a woman's breast cancer risk. However, data on the relationship between drinking alcohol during the period of time between a woman's first menstrual period and first pregnancy and the risk of proliferative BBD and breast cancer had not been reported. Breast tissue is particularly susceptible to carcinogens during that period of time. 
   
   Ying Liu, M.D., Ph.D., from the Washington University School of Medicine in St. Louis, MO, and colleagues analyzed data from 116,671 female registered nurses, aged 25-44 years, on medical history, reproductive history, and lifestyle. The data were collected using questionnaires as part of the Nurses' Health Study II (NHSII). Alcohol consumption in four age periods were obtained by asking participants about the total number of alcoholic drinks consumed at different ages (ages 15-17, 18-22, 23-30, and 31-40). After excluding women who did not meet the predetermined study criteria, a total of 91,005 women with a history of full-term pregnancy were included in the final analysis. Among these women, 1,609 cases of breast cancer and 970 cases of BBD occurred during the study period. These cases were confirmed by physicians who reviewed information from each patient's medical records. 
   
   Drinking alcohol between the first menstrual period and first pregnancy was associated with risk of breast cancer and proliferative BBD, regardless of drinking after the first pregnancy. The data indicated a dose-dependent relationship, which means the more alcohol a woman drinks during that time, the higher her risk of developing breast cancer. Also, the authors observed longer intervals between first menstrual period and first pregnancy showed stronger associations compared with shorter intervals. The authors also report drinking after the first pregnancy was associated with breast cancer risk but not BBD. 
   
   The authors write, "The general consistency in the patterns of association between alcohol and risk of proliferative BBD and of breast cancer lends support to the hypothesis that alcohol intake, particularly before first pregnancy when breast tissue is likely at its most vulnerable stage, may play an important role in the etiology of breast cancer." These findings have potentially important implications for breast cancer prevention. 
   
   Source: Journal of the National Cancer Institute
target: – Drinking a glass of wine a day may cut your heart disease risk, help you lose weight, or just make you generally healthier. But if you're a woman who hasn't had kids yet, it might also give you breast cancer, a new study suggests. The study found that women who had at least one drink a day between their first menstrual cycle and their first pregnancy were at significantly higher risk of eventually developing both benign and malignant breast cancer, HealthDay reports. "The risk increased by 11% for every 10 grams a day of intake, about six drinks per week," the study's author says. Previous research has suggested the alcohol-cancer link, and that waiting to have kids could increase your risk. But this is the first study to focus on alcohol in the pre-pregnancy period. Breast tissue is especially vulnerable to carcinogens during that window, Science Codex explains.