text: Scientists from Imperial College believe that intelligence may be influenced by two networks of genes, possibly controlled by a master regulatory system 
   
   British scientists believe they have made a huge step forward in the understanding of the mechanisms of human intelligence. That genetic inheritance must play some part has never been disputed. Despite occasional claims later dismissed, no-one has yet produced a single gene that controls intelligence. 
   
   But Michael Johnson of Imperial College London, a consultant neurologist and colleagues report in Nature Neuroscience that they may have discovered a very different answer: two networks of genes, perhaps controlled by some master regulatory system, lie behind the human gift for lateral thinking, mental arithmetic, pub quizzes, strategic planning, cryptic crosswords and the ability to laugh at limericks. 
   
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   As usual, such research raises potentially politically-loaded questions about the nature of intelligence. “Intelligence is a composite measure of different cognitive abilities and how they are distributed in a population. It doesn’t measure any one thing. But it is measurable,” Dr Johnson said. 
   
   About 40% of the variation in intelligence is explained by inheritance. The other factors are not yet certain. But the scientists raise the distant possibility that armed with the new information they may be able to devise ways to modify human intelligence. 
   
   “The idea of ultimately using drugs to affect cognitive performance is not in any way new. We all drink coffee to improve our cognitive performance,” Dr Johnson said. “It’s about understanding the pathways that are related to cognitive ability both in health and disease, especially disease so one day we could help people with learning disabilities fulfil their potential. That is very important.” 
   
   The two networks, known just as M1 and M3, one with roughly 1000 genes, the other with more than a 100, also play a role in neurodevelopmental disorders such as epilepsy, schizophrenia and autism. The functions do not seem to overlap, and the role of each network has yet to be settled. 
   
   “We know that genetics plays a major role in intelligence but until now haven’t known which genes are relevant. This research highlights some of the genes involved in human intelligence and how they interact with each other,” Dr Johnson said. “What’s exciting about this is that the genes we have found are likely to share a common regulation, which means that potentially we can manipulate a whole set of genes whose activity is linked to human intelligence.” 
   
   The discovery is testament to the power of patience, patients and the assembly of huge sets of data. The Imperial College scientists started with evidence from 100 mouse brains, 122 samples of human brain, and 102 whole human brains preserved postmortem. Such indicators of a genetic connection between neurodevelopmental problems or memory and understanding were then checked against records of 6,732 people in the “Generation Scotland” family health study, which tracks the life history of thousands of volunteers, and repeated in 1,003 healthy people who had volunteered to take part in a study called the Lothian Birth Cohort 1936. 
   
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   It assessed a range of cognitive abilities – among them memory, attention, processing speed and reasoning – and then it combined the results with genetic information donated by healthy people who had taken IQ tests, and from people with autism spectrum disorder and intellectual disability. Included in the research were studies of people who had undergone neurosurgery for epilepsy. 
   
   Then the scientists then harnessed massive computing power to see what the data could tell them. They found that the genes that influenced the intelligence and ability of healthy people were the same ones that impaired cognitive ability and caused epilepsy when mutated. If researchers understand what may go wrong in the interplay of inheritance that delivers human reasoning or memory, they might – the possibility for the moment is only theoretical – be able to devise new ways to deliver help. 
   
   “Traits such as intelligence are governed by large groups of genes working together - like a football team made up of players in different position,” he said. “We found that some of these genes overlap with those that cause severe childhood onset epilepsy or intellectual disability,” 
   
   The researchers may have identified a pool of players in a team: they still have to identify how the players co-operate, which are the key players and precisely what game is being played. 
   
   “Eventually we hope that this sort of analysis will provide new insights into better treatments for neurodevelopmental disease such as epilepsy, and ameliorate or treat the cognitive impairments associated with these devastating diseases.” 
   
   • This article was amended on 29 December 2015 to remove a reference to autism as a neurodevelopmental illness; it is a disorder, not an illness. ||||| STRADL - Stratifying Resilience and Depression Longitudinally In 2014, the Wellcome Trust awarded £4.8M to researchers in Edinburgh and Aberdeen to fund a study of depression using GS:SFHS. Experts say that rather than being one disease, clinical depression is a collection of different disorders with one common symptom – that of low mood. Over the next five years, scientists will study individual groups of people who have known depression risk factors such as a family history of low mood, early life problems such as being born underweight or psychological trauma in childhood. Participants will asked to complete new questionnaires on their mental health and resilience. A subset will also be invited to attend a new clinic visit in Aberdeen or edinburgh, which will include MRI brain imaging. By studying groupings of people both with and without depression in this way they hope to be able to identify its causes and mechanisms , which can be used in the quest for diagnostic tests and new therapies. Read more...
target: – Researchers from London's Imperial College think they've found two networks of genes, possibly controlled by a master system, that control cognitive functions—a find that may allow them to modify human intelligence down the line, the Guardian reports. In a study published in Nature Neuroscience, scientists say these M1 and M3 clusters control cognitive functions such as memory, attention, and reasoning, per the Daily Express. "Traits such as intelligence are governed by large groups of [genes] working together—like a football team made up of players in different [positions]," study co-author Dr. Michael Johnson says, per the Guardian. By figuring out how these "players" work together, scientists could perhaps boost cognitive abilities by simply flicking the equivalent of a master switch. And based on other findings in the study linking mutations of those same genes to cognitive impairments, research in this area may be lead to treatment of cognitive issues that accompany neurodevelopmental diseases such as epilepsy, Dr. Johnson notes, per the Guardian. Researchers analyzed "huge sets of data" taken from samples of mouse and human brains, the paper notes, as well as info from a previous health study and genetic data from volunteers (both healthy ones and those with autism and other intellectual disabilities) who took IQ tests. Not only did they find evidence for the disparate gene networks—they also found that the same genes that apparently contribute to the intelligence of healthy subjects damaged cognitive abilities if they were mutated. "Eventually we hope that this sort of analysis will provide new insights into better treatments for neurodevelopmental disease … and ameliorate or treat the cognitive impairments associated with these devastating diseases," Johnson says. Not everyone is thrilled with the idea of flipping a switch to play around with intelligence functioning. "Genetics is the science of inheritance, not pre-determinism, and there is no substitute for hard work and application," a University of Kent genetics professor tells the Express. (Predict your kid's intelligence—with a raisin.)