the direct nucleophilic substitution of alcohols is of high interest as it provides access to a wide variety of derivatives , with the formation of water as the only by - product .
indeed , the acs green chemistry institute pharmaceutical roundtable identified oh activation for nucleophilic substitutions as a priority area currently used in the preparation of pharmaceutical intermediates that would greatly benefit from the development of better methods.1 unarguably , propargylic substitutions have progressed substantially since the pioneering work of nicholas on octacarbonyldicobalt - stabilised propargylic cations.2 the versatility of the propargylic moiety as a synthon in organic chemistry as well as its occurrence in natural products and synthetic pharmaceuticals have been the main driving forces for these advances .
furthermore , propargylic alcohols are easily prepared from the corresponding aldehydes or ketones by addition of an alkynyl anion .
diverse transition metals,3 such as ruthenium , palladium , gold or silver,4 have been successfully used in this context .
however , the cost of the catalyst , together with its selectivity ( metal  allenylidene vs. metal  propargylic intermediates ) remain important issues to solve .
the direct displacement of  activated  alcohols  such as benzylic , allylic , and propargylic alcohols  can also be achieved using brnsted or lewis acids by simple sn1 reactions.5 important advantages of brnsted acids over lewis acids often include lower catalytic loadings and easier handling as they are generally more stable towards oxygen and water .
sulfonic acids are the most commonly used brnsted acids for the nucleophilic substitution of propargylic alcohols as described in extensive work by sanz and co - workers with p - toluenesulfonic acid.6,7 inorganic acids , such as phosphomolybdic acid on silica , have also been studied with c- , n- and o - nucleophiles.8 depending on the substrates , the reactions required either 10 mol-% of acid at room temperature , or 1 mol-% in refluxing toluene .
an additional asset of these inorganic acids is their straightforward separation from the organic products through a simple basic workup .
a common feature for all these catalytic systems is their compatibility with air and reagent - grade solvents , although they are mostly undesirable ones ( toxic , costly to dispose of , such as meno2 ) .
hbf4 is a common acid in academic and industrial laboratories that has found diverse applications in synthesis , either as a reagent ( nucleophilic fluorination,9 synthesis of vinylidene  metal complexes10 ) , or catalyst ( amidation of olefins,11 biginelli reaction,12 acylation of aldehydes13 ) .
crafts alkylation of benzylic alcohols in the presence of an excess of hbf4oet2 solution at 78 c has been reported.14 even though high diastereoselectivities could be achieved with this methodology , the excess of acid and low reaction temperatures represent important drawbacks . herein , we report the use of hbf4 as a highly efficient catalyst for sn1 reactions of propargylic alcohols with different nucleophiles under mild , simple reaction conditions .
in a first step , the effect of different solvents was tested on the reaction of propargylic alcohol 1a with meoh to give 2a with 1 mol-% of hbf4 ( table1 ) .
of meoh and a commercially available 48 wt.-% solution of hbf4 in water as catalyst .
no attempts were made to optimise the reaction times . whereas sluggish reactions were observed in thf or in water ( table1 , entries 1 and 2 ) ,
high conversions were obtained in dcm , acetonitrile , and acetone ( table1 , entries 46 ) .
overall , acetone was chosen as our preferred solvent because of its greener profile.15 it is important to note that all tested solvents were technical grade , and in particular , the acetone employed in these reactions was standard laboratory washing acetone .
schuster rearrangement16 was not observed either in the model reaction or during the study of the scope of the reaction .
the use of different o - nucleophiles was first explored ( scheme  1 ) .
propargylic alcohol 1a was treated with different primary and secondary alcohols to form the expected ethers 2a  h in high yields under our standard conditions .
when chiral alcohols were used , the corresponding ethers 2 g and 2h were formed as a mixture of inseparable diastereoisomers . a tertiary alcohol , tbuoh , only led to low yields of the ether 2i , and the major product of that reaction ( 51  % conversion ) formed from dimerisation of the starting propargylic alcohol ( 3a ; vide infra for further details ) . on the other hand , an ortho - disubstituted aryl group was not detrimental to the reactivity of the propargylic alcohol , as exemplified with the formation of 2k . also ,
unlike most transition - metal - based methodologies,3 the reaction is not limited to terminal alkynes , and alkyl ( 2j , 2k ) , aryl ( 2l ) or silyl groups ( 2 m , 2n ) at the acetylenic position did not have any major effect on the outcome of the reaction ( scheme  1 ) .
also , several functional groups ( ketone , halogen or sulfone ) were shown to be compatible with the reaction conditions . in the absence of any other nucleophile , the starting propargylic alcohol dimerised to form the symmetrical ether as a mixture of diastereoisomers ( scheme  2 ) .
dr = diastereoisomeric ratio . [ a ] isolated yields ; h nmr conversions are provided in parentheses when lower than 95  % . [ b ] 51  % h nmr conversion into dimer 3a .
[ a ] isolated yields ; h nmr conversions are provided in parentheses when lower than 95  % .
on the other hand , when r on the starting propargylic alcohol was not an electron - rich aryl group , no reaction was observed at room temperature . in most cases , however , the formation of the desired ethers was possible by increasing the reaction temperature and/or the acid loading ( table2 ) .
good yields could be then obtained , except for a nitro - substituted substrate ( table2 , entry 4 ) .
it is important to note that , since no decomposition or undesired reactions were observed at room temperature , this difference in reactivity could be used to selectively functionalise a more complex molecule with two electronically dissimilar propargylic alcohols ( vide infra ) .
isolated yields ; h nmr conversions are provided in parentheses when lower than 95  % ; n.r . =
the inherent basicity of most amines is an obvious potential limitation of any brnsted acid catalysed reaction as they might simply neutralise the catalyst .
our conditions , however , could be successfully applied to different carbamates and sulfonamides , as well as weakly basic anilines ( scheme  3 ) , and the expected products 4 were prepared in good yields at room temperature , with the exception of 4e .
[ a ] isolated yields , h nmr conversions are provided in parentheses when lower than 95  % . [ b ] reaction carried out with 5 mol-% of hbf4 at 60 c .
carbon nucleophiles were also investigated , and diketones as well as electron - rich arenes reacted to form the expected products 5 in good to excellent yields ( scheme  4 ) .
very similar results were obtained with pentane-2,4-dione and a variety of substituted propargylic alcohols . for the formation of 5d , with an electron - neutral aryl group at the propargylic position , a higher catalyst loading and an elevated temperature were required in order to obtain high conversions .
phenol also reacted efficiently in a friedel  crafts - type reaction,17 to give para - substituted derivatives 5e  g exclusively .
when using 2-phenylphenol as the nucleophile , the hydroxy group had a stronger directing power than the arene , as expected ( scheme  4 , compound 5h ) .
we then tested a phenol with a second strongly activating group at the para position ( 4-methoxyphenol , for the formation of 5i ) . in this case , only the product derived from reaction at the ortho position to the phenol was isolated .
a ] isolated yields ; h nmr conversions are provided in parentheses when lower than 95  % .
[ b ] reaction carried out with 5 mol-% of hbf4 in mecn at 80 c .
surprisingly , allyltrimethylsilane proved to be a very poor reaction partner for the substitution of propargylic alcohols with hbf4 as the catalyst .
low conversions were obtained in either acetone or hot toluene , even when higher catalyst or nucleophile loadings were used ( table3 ) .
overall , the best results were obtained in mecn at 80 c , and still product 5j could only be isolated in 50  % yield .
it is important to note that alcohol 1a was stable under the studied conditions , and besides the expected product 5j , only 1a and ether 3a were evidenced in the h nmr spectra .
hence , no amide formation , which could potentially take place by a ritter reaction,18,19 was observed under these conditions .
when furan was used as nucleophile , the h nmr spectrum of the crude reaction mixture showed the formation of a complex mixture of products .
prompt purification allowed the isolation of 5k in moderate yield , but it is important to note that 5k still decomposed rapidly after purification .
these observations were perhaps not surprising as many furan derivatives are well - known to be acid - sensitive .
this is also the case for some indoles , but as it can be seen in table4 , better yields were obtained with this important family of heterocyclic nucleophiles.20 hbf4-catalysed propargylation reactions of heterocycles .
isolated yields ; h nmr conversions are provided in parentheses when lower than  95  % .
reaction carried out with 5 mol-% of hbf4 in toluene at 80 c . in order to investigate the influence of substitution on the nucleophile ,
different indole derivatives were treated with the same propargylic alcohol 1a . 1-methyl- and 1h - indoles reacted regioselectively at c-3 , as expected , leading to the formation of 5l and 5 m , respectively , in good yields .
this might be due to a higher instability under acidic conditions or its low solubility either in acetone or dcm . even under more forcing conditions ( 5 mol-% of acid at 80 c ) , no evidence for reaction of the hydroxy group could be detected .
gratifyingly , products 5o  q , derived from a friedel  crafts reaction at c-2 could be prepared under very simple reaction conditions . to the best of our knowledge ,
this is the first example of the synthesis of 2,3-disubstituted indoles by brnsted acid catalysed propargylation reactions.21 some of the reactions in table4 were carried out in dcm , instead of acetone , to avoid the formation of undesired by - products .
it has previously been reported that indoles can react with ketones or aldehydes as electrophiles under acidic conditions.22 indeed , when 1-methylindole was treated with propargylic alcohol 1a under our standard conditions in acetone , the expected product 5l was formed preferentially , but it was contaminated with bis(indole ) 6 ( scheme  5a ) .
the high yield obtained of 5l indicates that the indole reacts preferentially with the propargylic cation formed from 1a and that the reaction between the excess of indole and acetone is quite sluggish .
the formation of 6 remains undesirable , and hence acetone was avoided as a solvent for these reactions .
more problematic was the reaction of 1a with tryptophol as nucleophile ( scheme  5b ) . in this case the expected product could only be isolated in 40  % yield because of a competitive oxa - pictet 
spengler acid - catalysed cyclocondensation of tryptophol with the solvent,23 which consumed 70  % of the available nucleophile .
next , two competition experiments were performed to exploit the particular activity of hbf4 in propargylation reactions ( scheme  6 ) .
firstly , relatively electron - rich alcohol 1a reacted selectively in the presence of 1 g , bearing a chloro substituent at the para position of the phenyl ring ( scheme  6a ) .
also , the unexpected diminished reactivity of allylsilanes as nucleophiles was exploited when 1a was treated with 2 equiv . of benzyl alcohol and 2 equiv .
only 2b , derived from the reaction with benzyl alcohol , was formed under these conditions .
importantly , these chemoselectivities are not possible when using other brnsted acids reported for this transformation , such as p - toluenesulfonic acid,6a or phosphomolybdic acid.8a competition experiments with hbf4 .
finally , a gram - scale reaction was performed to further demonstrate the applicability of this reaction , and compound 5r was isolated in high yield when using our optimised conditions ( scheme  7 ) .
the scope and limitations of hbf4 as a practical catalyst for propargylation reactions have been explored . in general ,
good to excellent yields for the formation of c  o , c  n and c 
c bonds were obtained under exceptionally simple reaction conditions . challenging substrates such as electron - poor propargylic alcohols , or acid - sensitive indoles could be used with this methodology , even if slightly more forcing conditions were sometimes required .
all reactions were carried out in air and in technical solvents , and the acid used was a commercially available aqueous solution .
all the reactions were also completely regioselective , and no allene products were observed in any case .
furthermore , many of the reactions were extremely clean , and the desired products could be isolated analytically pure without the need for further purification after a simple aqueous workup ( i.e. , 2a , 2j , 2l  o , 5b  c ) .
overall , this is a convenient and powerful methodology that does not employ a costly metal catalyst .
for instance , we were pleased to see that an allylic alcohol also reacted with meoh at room temperature in very high yields ( scheme  8) .
general procedure for the nucleophilic substitution of propargylic alcohols : in a vial fitted with a screw cap and a stirring bar , the propargylic alcohol 1 ( 1 mmol ) , nucleophile ( 2 mmol ) and technical acetone ( 2 ml ) were introduced .
an aqueous solution of hbf4 ( 48 wt.-% , 1.2 l,1 mol-% ) was then added , and the reaction mixture was stirred at room temperature for 18 h. the reaction was quenched with a saturated aqueous solution of nahco3 and the mixture extracted with ethyl acetate .
the combined organic extracts were washed with brine , dried with anhydrous mgso4 , filtered , and concentrated under reduced pressure to give the title compound .
as a service to our authors and readers , this journal provides supporting information supplied by the authors .
such materials are peer reviewed and may be re - organized for online delivery , but are not copy - edited or typeset . technical support issues arising from supporting information ( other than missing files ) should be addressed to the authors
 the activity of hbf4 ( aqueous solution ) as a catalyst in propargylation reactions is presented . 
 diverse types of nucleophiles were employed in order to form new c  o , c  n and c  
 c bonds in technical acetone and in air . 
 good to excellent yields and good chemoselectivities were obtained using low acid loading ( typically 1 mol-% ) under simple reaction conditions . 