recurrent pharyngotonsillitis is a common health problem causing medical appointments , antimicrobial treatments , and missed workdays or schooldays .
previously , we conducted two randomised controlled trials in adults with recurrent pharyngotonsillitis on the efficacy of tonsillectomy [ 2 , 3 ] .
while we noticed that tonsillectomy reduced the number of acute pharyngotonsillitis episodes and increased the quality of life , we also found out that the patients graded most of their episodes as nonsevere [ 3 , 4 ] .
thus , it seems like something other than the severity of throat pain may affect whether or not the patient consults the health care system during a pharyngitis episode . here
, we sought patient- and episode - related factors that would explain whether or not the patient made a medical visit for acute sore throat both before and after tonsillectomy .
study design was a secondary analysis of two randomised controlled trials exploring the effect of tonsillectomy in reducing further episodes of sore throat in adult patients with recurrent pharyngotonsillitis .
these trials have been described previously [ 2 , 3 ] . in brief , the first trial ( streptococcal material ) included 70 adults who had had at least 3 episodes of pharyngotonsillitis in 6 months or 4 episodes in 12 months , with one of them having to be of streptococcal origin .
the second trial ( pharyngotonsillitis material ) involved 86 adults who had had at least 3 episodes of pharyngotonsillitis of any origin in 12 months .
half of the participants were randomly assigned to immediate tonsillectomy and the other half to a waiting list .
thus , we followed up both operated and unoperated patients for approximately 5 to 6 months .
grades 3 and 4 tonsils according to the grading scale by brodsky were regarded as large .
tonsils were regarded as chronically infected if they were inflamed and cryptic and these crypts contained debris .
the patients were given a symptom diary where they recorded the presence of throat pain , fever , cough , and rhinitis .
in the pharyngotonsillitis material , also the severity ( mild , moderate , or severe ) of the throat pain was recorded .
the patients were told to seek medical advice for their acute symptoms during the trial in exactly the same way they had done before .
physicians recorded the date , location , diagnosis , and treatment of acute episodes as guided by trial instructions .
acute pharyngitis is a sudden inflammation or infection of the pharynx , usually causing a sore throat .
acute tonsillitis , on the other hand , is a sudden infection or inflammation of one or both of the palatine tonsils . in this paper
, we use the term pharyngotonsillitis for simplification for all the patients , since we have studied patients with sore throat episodes both before and after tonsillectomy .
for descriptive data , we calculated means with standard deviations or ranges . to explore patient - related variables and medical consultations
, we constructed kaplan - meier curves for each of the 156 patients , starting from the date of the randomisation .
we calculated the cumulative incidence of a medical consultation up to 5 months of follow - up using life - table analysis .
we used a cox proportional - hazards regression model to explore associations between various patient - related factors and medical consultations for sore throat .
the cumulative risk of visiting a physician was calculated as an adjusted hazard ratio ( hr ) with 95% confidence intervals ( cis ) .
the model included the following variables : age ( 20 or > 30 years versus 2130 years ) ; gender ; tobacco use ; prior streptococcal pharyngotonsillitis ; number of episodes of pharyngotonsillitis in the prior 6 months ( 3 versus > 3 ) ; and chronically infected tonsils .
the associations between patient - related factors and medical consultations were similar in the episodes before and after tonsillectomy , so these two datasets were combined . to study episode - related factors and medical consultations , we similarly constructed kaplan - meier curves of each of the 208 episodes of acute pharyngotonsillitis , starting from symptom onset .
the primary end point was the first visit to a physician because of pharyngotonsillitis during the first 7 days .
we calculated the cumulative incidence of a medical consultation up to the first week of symptoms using life - table analysis .
we used a cox regression model to explore the associations between various episode - related factors and medical consultations .
the cumulative risk of visiting a physician was calculated as an adjusted hr with 95% cis .
the model included the following variables : maximum throat pain during the episode ( mild versus moderate versus severe ) ; fever ; other respiratory symptoms ; and pre- versus postoperative episode .
the mean length of the follow - up was 5.9 ( sd 1.2 ) months .
female gender ( hr 3.3 , 95% ci 1.48.0 ) and chronically infected tonsils at clinical examination ( hr 2.7 , 95% ci 1.26.1 ) were factors that associated with medical consultation during a pharyngotonsillitis episode ( table 2 ) ( figure 1(a ) ) .
age , tobacco use , prior streptococcal pharyngotonsillitis , and frequent pharyngotonsillitis episodes did not affect the consultation rate .
seventy - eight patients had 208 acute pharyngotonsillitis episodes ( mean duration of 6.2 days , sd 4.5 ) .
thirty - six episodes ( 17% ) led to a medical consultation during the first 7 days of symptoms and the mean duration of symptoms before consultation was 4.1 ( sd 3.6 ) days .
the risk for medical visit increased after the third day of symptom onset ( figure 1(b ) ) . only the fact
that the patient had had severe throat pain during the first 7 days correlated significantly with the medical consultation ( hr 4.3 , 95% ci 1.018.5 ) ( table 2 ) . in contrast , having had moderate throat pain , fever , the presence of other respiratory symptoms , and whether the episode was pre- or postoperative were not associated with the medical consultation .
we found that acute pharyngotonsillitis episodes both before and after tonsillectomy lasted less than a week ; on average , majority of cases involved at most only nonsevere throat pain and less than one - third involved fever .
thus , it was not surprising that only one of every six episodes led to medical consultation .
we found that the medical appointment rate for acute pharyngotonsillitis was higher in women than in men .
this higher consultation rate may lead to an increased amount of recurrent pharyngotonsillitis diagnoses and may further increase referrals to specialist care for tonsillectomy among women . in fact
earlier literature reports that women have higher consultation rates with specialists for consideration of paranasal surgery due to recurrent acute rhinosinusitis , as well [ 79 ] .
severe throat pain during the acute pharyngotonsillitis episode increased the probability of a medical visit after the third day of symptom onset .
this finding indicates that patients are mainly looking for relief from severe pain and also suggests that patients may be aware that milder episodes usually heal by themselves without medical care [ 10 , 11 ] .
in contrast , such factors as age , tobacco use , streptococcal pharyngotonsillitis in history , fever , and whether the episode occurred before or after tonsillectomy did not correlate with a medical visit . to minimize the effect of participating in a trial
, we emphasized that it was important that the patients seek medical advice for their symptoms during the trial in exactly the same way they had done before .
this study was done in a country where national guidelines suggest that tests should be done for -haemolytic streptococcus a when treating acute pharyngotonsillitis , which must be considered when the generalizability of the results is evaluated . to conclude , even among adult patients who suffered from recurrent pharyngotonsillitis episodes , the overwhelming majority of the acute pharyngotonsillitis episodes were mild and only few resulted in a medical consultation , with female gender , chronically infected tonsils , and having severe throat pain increasing the consultation rate .
 
 objects . to seek patient- and episode - related factors that associate with medical consultation for acute sore throat because these factors may affect the patient being referred to specialist care and tonsillectomy for recurrent pharyngotonsillitis . methods . in a secondary analysis of two prior 
 randomised controlled trials , sore throat episodes and medical visits were explored among 156 adult patients referred for tonsillectomy because of recurrent pharyngotonsillitis . 
 results . 
 the 156 patients ( 104 females , mean age of 26 years ) suffered from 208 acute pharyngotonsillitis episodes during 5 - 6 months of follow - up . 
 forty ( 25% ) patients visited a physician , and female gender ( adjusted hazard ratio , hr , 3.3 ; 95% confidence interval 1.48.0 ) and finding of chronically infected tonsils ( hr 2.7 ; 1.26.1 ) were associated with medical consultation . 
 thirty - six ( 17% ) episodes led to medical consultation during the first 7 days of symptoms . 
 presence of severe throat pain was related to medical visit ( hr 4.3 ; 1.018.5 ) . 
 conclusions . even among patients with recurrent pharyngotonsillitis , 
 the acute sore throat episodes were usually mild and only few resulted in medical consultation , with female gender , chronically infected tonsils , and having severe throat pain increasing the consultation rate . 