angioma serpiginosum is a benign vascular nevoid disorder with proliferation and ectatic dilatation of capillaries in the papillary dermis .
most cases are sporadic but familial cases suggesting an autosomal dominant inheritance have also been described .
we report a case of late onset angioma serpiginosum localised to the breast , an unusual site .
a 46-year - old female patient presented to the dermatology out - patient clinic with an asymptomatic , progressive red eruption on the right breast of 4 years duration .
she did not provide a history of bleeding disorder , preceding trauma , or contact allergy prior to the eruption of the lesions .
clinical examination revealed multiple punctate macules in a serpiginous pattern against a bluish background , grouped at places , located on the lateral half of the right breast .
a 3 mm , red , soft papule was noted overlying these lesions at their lower extent [ figure 1 ] .
multiple , punctate macules in a serpiginious pattern against a bluish background on the right breast with a red smooth papule at the inferior aspect the differentials considered were angioma serpiginosum , unilateral nevoid telangiectasia , pigmented purpuric dermatoses and telangiectasia macularis eruptiva perstans .
epiluminescence microscopy with heine delta 20 dermatoscope ( heine optotechnik , herrsching , germany ) revealed multiple well demarcated oval to round red lagoons [ figure 2 ] .
epiluminescence microscopy ( 20 ) revealing the well demarcated red lagoon appearance histopathological examination of the nonblanching punctate macules showed a normal to mildly orthohyperkeratotic epidermis with dilated thin walled capillaries in the papillary dermis .
there was no evidence of extravasation of erythrocytes , inflammatory cell infiltrate or deposition of hemosiderin in the surrounding tissue [ figure 3 ] .
periodic acid - schiff ( pas ) stain showed a thick cuff of amorphous acidophilic pas - positive diastase - resistant material surrounding the dilated vessels [ figure 4 ] .
the red papule overlying the punctate macules revealed a well delineated papillary dermal lesion composed of closely placed ectatic thin walled capillaries engorged with erythrocytes that was consistent with a diagnosis of cherry angioma [ figure 5 ] . the clinical examination complemented by epiluminescence microscopy and
she was advised ophthalmic examination , which was refused and no further treatment was sought .
dilated thin walled capillaries ( arrow ) in the superficial papillary dermis with an unremarkable deep papillary and reticular dermis .
there is no extravasation of erythrocytes , inflammatory cell infiltrate or deposition of hemosiderin in the surrounding tissue ( h and e , 200 ) cuff of periodic acid - schiff ( pas ) positive diastase - resistant material ( arrow ) surrounding the dilated vessels ( pas , 200 ) well delineated papillary dermal lesion composed of closely placed ectatic thin walled capillaries engorged with erythrocytes ( h and e , 100 )
first described by hutchinson in 1889 and named by radcliffe - crocker in 1893 , angioma serpiginosum consists of multiple red , minute , nonblanchable and grouped macules , resembling purpura , in a serpiginous or gyrate pattern with a background of erythema or violaceous hue .
. the erythematous or violaceous background hue may be due to dilatation of the subpapillary venous plexus .
the eruption usually affects teenage females and in 90% cases has its onset before the age of 16 years .
it commonly affects the lower extremities and buttocks and is often asymmetric . any anatomic site with exceptions of the mucocutaneous junctions , palms and soles
can be affected , though there has been a case report describing plantar involvement as well as reports of disseminated distribution .
majority of cases occur in females and are of childhood onset . in view of female preponderance and progression of lesions in pregnancy ,
the role of hormonal stimuli has been refuted by the absence of estrogen - progesterone receptor stimulation .
epiluminescence microscopy reveals demarcated red lagoon appearance due to the presence of increased and dilated vascular spaces in the papillary dermis and can help distinguish the condition from purpuric dermatoses on the basis of typical lagoon pattern .
histopathological findings include a normal epidermis , dilated thin walled capillaries in the papillary dermis without an extravasation of red blood cells or deposition of hemosiderin in the surrounding tissue .
the capillary walls may be thickened due to deposition of pas positive material around blood vessels .
the absence of dermal mast cell increase , hemosiderin deposition and red blood cell extravasation in our case ruled out the differential diagnoses that were considered .
it was first described by campbell de morgan in 1872 . generally developing after the third decade
clinically , early lesions appear as flat , red macules that look like petechiae that later evolve into 1 - 5 mm red papules .
these are known to be related to chemical exposures , with liver transplants , graft - versus - host disease , and secondary to cyclosporine treatment . in the absence of
any known inciting factors , it is assumed that our patient had an incidental onset of solitary cherry angioma or as a result of chronological ageing .
histological examination of cherry angiomas shows numerous , newly formed capillaries in a lobular pattern in the papillary dermis .
there have reports of two female patients with chest wall involvement with the onset at 7 and 9 years of age
. chest involvement has also been described as a part of disseminated lesions in three patients .
two of these patients were beyond 50 years of age at presentation with the onset of their lesions in early childhood .
angioma serpiginosum has been described to be associated with angiokeratoma of the vulva in contiguous areas .
however , there has not been any report of cherry angioma in association with lesions of angioma serpiginosum or overlying the lesions .
our patient presented with a solitary cherry angioma superimposed on the angioma serpiginosum with the onset beyond 40 years of age and on the breast that is an unusual site for the latter . to the best of our knowledge
, there has been no reported case of this entity with late onset lesions in the english language literature .
co - existence of cherry angioma is assumed to be a result of chronological ageing process or may be secondary to a common vascular origin of both these lesions .
 angioma serpiginosum is a cutaneous vascular nevoid disorder that presents as red , nonblanchable and grouped macules distributed in a serpiginous pattern and resembles purpura . 
 it usually begins in childhood and commonly affects the lower limbs and the buttocks . 
 late onset of the lesions is unusual . 
 we report a 46-year - old female who presented with progressively extending lesions on her breast since preceding four years . 
 she also had a cherry angioma overlying the lesions , an observation hitherto not reported so far . 