patients with heart failure ( hf ) older than 65 years have a two - fold increased risk of cognitive impairment than elders without hf ( 1 ) .
the prevalence of cognitive impairment in adults with chronic heart failure is recognized as a factor contributing to the complexity of care for these patients ( 2 ) .
cognitive impairment may impact the ability to perform heart failure self - care procedures and is associated with an increased risk of re - hospitalization and mortality ( 3 ) .   despite the prevalence of these two conditions , cognitive impairment in hf patients
is usually underestimated by physicians ( 4 ) and currently , there is insufficient evidence to develop recommendations for strategies to improve cognitive impairment for hf patients ( 5 ) .
this study was designed to determine factors related to cognitive impairment among elder with hf .
in this descriptive , correlational , cross - sectional study , 184 patients with chronic heart failure were selected from four mazandaran university of medical sciences teaching hospitals using convenience sampling : imam khomeini hospital in behshahr , fatemeh zahra heart center in sari , imam khomeini hospital in fereydunkenar and imam khomeini hospital in noor .
patients hospitalized for symptomatic heart failure between october 2013 and january 2014 were included in this study and confirmed by the cardiologists .
inclusion criteria were a history of at least six months involvement with heart failure , age  60 , and remaining stable 1 - 2 days after admission .
exclusion criteria were communication problems such as severe hearing impairment ( without hearing aids ) , speech problems , severe cognitive impairment with abbreviated mental test ( amt ) scores < 4 ( 6 ) and uncooperativeness .
after providing written informed consent , each patient was interviewed by an independent data collector who was not involved in the patient s care .
socio - demographic variables consisted of age , gender , location , living status , education level , and income .
clinical variables consisted of left ventricular ejection fraction ( ef ) , poly - pharmacy (  5 different drugs ) , comorbidities ( charlson comorbidity index ) , blood pressure , depressive symptoms , body mass index ( bmi ) , number of hospitalizations during the previous six months , and some biochemical characteristics of the blood . these variables were collected from patients medical records and by interviews .
cognitive status was measured using the iranian version of the abbreviated mental test . the ideal cut - off point reported 6 , while sensitivity and specificity identified at 88 and 99% , respectively ( 6 ) , using a 10-item scale .
each correct answer received a score of 1 and incorrect answers were scored as 0 .
a total score of  6 indicates the presence of cognitive impairment ( a score of 0 - 3 indicates severe cognitive impairment and 4 - 6 indicates moderate cognitive impairment ) .
the severity of comorbid conditions was assessed using the charlson comorbidity index ( 7 ) , which classifies comorbidities based on the number and seriousness of one - year survival , with higher scores indicating greater risk of death .
most diseases are assigned a score of 1 on the index , but more severe conditions are given a weight score of 2 , 3 or 6 .
fisher s exact test and logistic regression were used to compare cognitive status scores with demographic characteristics and disease related variables .
the independent samples t - test was used to compare biochemical characteristics of the blood from the subjects both with and without cognitive impairment .
socio - demographic variables consisted of age , gender , location , living status , education level , and income .
clinical variables consisted of left ventricular ejection fraction ( ef ) , poly - pharmacy (  5 different drugs ) , comorbidities ( charlson comorbidity index ) , blood pressure , depressive symptoms , body mass index ( bmi ) , number of hospitalizations during the previous six months , and some biochemical characteristics of the blood . these variables were collected from patients medical records and by interviews .
cognitive status was measured using the iranian version of the abbreviated mental test . the ideal cut - off point reported 6 , while sensitivity and specificity identified at 88 and 99% , respectively ( 6 ) , using a 10-item scale .
each correct answer received a score of 1 and incorrect answers were scored as 0 .
a total score of  6 indicates the presence of cognitive impairment ( a score of 0 - 3 indicates severe cognitive impairment and 4 - 6 indicates moderate cognitive impairment ) .
the severity of comorbid conditions was assessed using the charlson comorbidity index ( 7 ) , which classifies comorbidities based on the number and seriousness of one - year survival , with higher scores indicating greater risk of death .
most diseases are assigned a score of 1 on the index , but more severe conditions are given a weight score of 2 , 3 or 6 .
test and logistic regression were used to compare cognitive status scores with demographic characteristics and disease related variables .
the independent samples t - test was used to compare biochemical characteristics of the blood from the subjects both with and without cognitive impairment .
the amt mean was 6.18  2.002 ( minimum 4 and maximum 10 ) , with 95% ci ( 5.89 to 6.48 ) . the majority of the elders in the study ( 110 persons , 59.8% ) had scores of 4 - 6 and the others ( 74 persons , 40.2% ) had scores of 7 - 10 .
females made up 61.4% of participants ( 113 persons ) and 38.6% ( 71 persons ) were male .
the 60 - 75 age group comprised 70% of the subjects ( 128 persons ) , 29% ( 54 persons ) were in the 75 - 90 age group and 1% ( 2 persons ) were in the 90 - 94 age group .
the mean ages in women and men were 70.7  8.35 and 70.01  8.99 , respectively ( p = 0.595 ) .
the ci odds ratio was higher in older patients than in the younger ones ( p = 0.002 ) .
in addition , the ci odds ratio was higher in female subjects than male ( p < 0.001 ) ( table 1 )
. there were significant relationships between cognition status scores and living status ( p < 0.001 ) and also between cognition status scores and education level ( p < 0.001 ) ( table 2 ) .
values are expressed as mean  sd . the ci odds ratios were higher in subjects with an ejection fraction of < 40% compared to subjects with an ejection fraction of  40% ( p = 0.002 ) ( table 1 ) .
fisher s exact test results showed a significant relationship between cognitive status scores and hypertension ( p = 0.039 ) and also between cognitive status scores and anemia ( p = 0.046 ) .
although the ci odds ratio was higher among subjects with hypertension and anemia , there was not a significant relationship ( table 1 ) .
there was no significant correlation between biochemical characteristics of the blood and cognitive status scores .
however , there was a near - significant level for hemoglobin , blood urea nitrogen ( bun ) and systolic blood pressure ( table 3 ) .
values are expressed as mean  sd . the mean of charlson comorbidity index and depression symptoms were higher among subjects with cognition impairment ( p < 0.001 ) ( table 4 ) .
the amt mean was 6.18  2.002 ( minimum 4 and maximum 10 ) , with 95% ci ( 5.89 to 6.48 ) . the majority of the elders in the study ( 110 persons , 59.8% ) had scores of 4 - 6 and the others ( 74 persons , 40.2% ) had scores of 7 - 10 .
females made up 61.4% of participants ( 113 persons ) and 38.6% ( 71 persons ) were male .
the 60 - 75 age group comprised 70% of the subjects ( 128 persons ) , 29% ( 54 persons ) were in the 75 - 90 age group and 1% ( 2 persons ) were in the 90 - 94 age group .
the mean ages in women and men were 70.7  8.35 and 70.01  8.99 , respectively ( p = 0.595 ) .
the ci odds ratio was higher in older patients than in the younger ones ( p = 0.002 ) .
in addition , the ci odds ratio was higher in female subjects than male ( p < 0.001 ) ( table 1 ) .
there were significant relationships between cognition status scores and living status ( p < 0.001 ) and also between cognition status scores and education level ( p < 0.001 ) ( table 2 ) .
the ci odds ratios were higher in subjects with an ejection fraction of < 40% compared to subjects with an ejection fraction of  40% ( p = 0.002 ) ( table 1 ) .
fisher s exact test results showed a significant relationship between cognitive status scores and hypertension ( p = 0.039 ) and also between cognitive status scores and anemia ( p = 0.046 ) .
although the ci odds ratio was higher among subjects with hypertension and anemia , there was not a significant relationship ( table 1 ) .
there was no significant correlation between biochemical characteristics of the blood and cognitive status scores .
however , there was a near - significant level for hemoglobin , blood urea nitrogen ( bun ) and systolic blood pressure ( table 3 ) .
values are expressed as mean  sd . the mean of charlson comorbidity index and depression symptoms were higher among subjects with cognition impairment ( p < 0.001 ) ( table 4 ) .
in this study , the prevalence of cognitive impairment was higher among elderly subjects with a lower level of education , patients living alone or with their children , and females .
it seems that fewer years of education contribute to processing speed ( 2 ) . providing social support another important factor that may decrease patient stress and improve cognitive status .
the results of the present study show that comorbidities contribute to cognitive impairment in hf patients .
these findings are consistent with other studies ( 2 , 9 , 10 ) , but differ from that of pressler et al . who found no association between comorbidities and cognitive status ( 11 ) .
in this study , there were significant relationships between cognitive impairment with depression , hypertension , and anemia .
these findings are consistent with some studies ( 9 , 10 ) . in a clinical setting , it is hard to differentiate mild stages of dementia and late life depression , because both situations may have similar presentations ( 12 ) .
few studies have directly examined the association between cognitive impairment and depression in persons with heart failure , despite the likelihood of common mechanisms ( 13 ) .
persons with heart failure exhibit numerous pathological changes on neuro - imaging , including greater atrophy and the presence of white matter hyper - intensities , frequently in frontal brain regions ( 14 ) .
hypertension has a significant impact on cardiovascular function , cerebral structural integrity and associated cognitive deterioration ( 15 , 16 ) .
the most common explanation for the deleterious effect of hypertension on cognition is that hypertension increases cerebrovascular disease ( 17 ) .
some longitudinal studies have shown a positive association between hypertension and cognitive impairment ( 15 , 16 ) .
these effects were independent of clinical strokes and the association was stronger in individuals who did not use antihypertensive drugs ( 15 ) .
the results of some studies indicate that hypertension may be a risk factor dementia , especially alzheimer s disease ( ad ) ( 18 , 19 )
. however , the factors that predispose individuals with hypertension to developed ad are unknown ( 20 ) .
there have been very few studies on the association of anemia with cognitive status ( 22 ) .
the literature on the association between anemia and dementia is also limited and the results are inconsistent ( 23 , 24 ) .
anemia in heart failure may have multiple origins , which are thought to involve reduced erythrocyte production , decreased bmi , and hemodilution ( 25 ) .
further contributors to the risk of anemia in hf are comorbid renal disease and increased inflammation ( 26 ) .
elevated levels of pro - inflammatory cytokines may also inhibit hematopoietic proliferation ( 27 ) .
in addition , some medications , such as angiotensin - converting enzyme ( ace ) inhibitors and angiotensin receptor blockers , reduce erythropoietin production ( 25 ) .
first , this is a cross - sectional study and the correlations can not imply causation relationships between parameters .
moreover , the data represent only the subjects who agreed to participate in the study . identifying factors affecting cognitive impairment in hf may help clinicians in directing educational interventions on disease management to families to possibly prevent readmission of their loved ones .
further research to determine the feasibility and acceptability of cognitive assessment in routine clinical care is suggested .
first , this is a cross - sectional study and the correlations can not imply causation relationships between parameters .
moreover , the data represent only the subjects who agreed to participate in the study .
identifying factors affecting cognitive impairment in hf may help clinicians in directing educational interventions on disease management to families to possibly prevent readmission of their loved ones .
further research to determine the feasibility and acceptability of cognitive assessment in routine clinical care is suggested .
 backgroundpatients with heart failure ( hf ) older than 65 years have a two - fold increased risk of cognitive impairment than elders without hf . 
 identifying factors affecting cognitive impairment in hf may present targets for intervention.objectivesthe aim of the present study was to determine cognitive function and related factors among elderly patients with heart failure.patients and methodsin this cross - sectional study , 184 elderly patients with heart failure were selected from four mazandaran university of medical sciences teaching hospitals using convenience sampling . 
 data were collected from patients medical records and by interview , using the abbreviated mental test , geriatric depression scale , and charlson comorbidity index.resultsthere were significant relationships between cognitive status and living arrangement ( p < 0.001 ) , education ( p < 0.001 ) , hypertension ( p = 0.039 ) , anemia ( p = 0.046 ) , charlson comorbidity index ( p < 0.001 ) and geriatric depression scale ( p < 
 0.001).conclusionsscreening of cognitive impairment in elderly patients with heart failure seems necessary . 