kidney diseases are common in hiv - infected patients.17 the most common one is hiv - associated nephropathy ( hivan ) , as well as drug toxicities of various kinds .
interstitial nephritis is a possible complication of hiv infection.8,9 it is usually caused by drugs such as indinavir , foscarnet , abacavir , and co - trimoxazole ; mycobacterial infections ; infections by other viruses ; or dysimmune syndromes such as immune reconstitution inflammatory syndrome and diffuse infiltrative lymphocytosis syndrome ( dils ; table 1).10,11 interstitial nephritis might occur as a direct consequence of hiv infection , but cases demonstrating this through exclusion of other etiologies are rare . herein , we present a case of interstitial nephritis that was likely caused directly by hiv infection and not by other etiologies .
a 34-year - old african man was referred to our hospital because of microscopic hematuria identified at an annual health checkup at his workplace . the patient had no significant past medical history and was not taking any medications .
the patient gave written informed consent to be included in this case report . upon initial routine workup ,
the patient s serum creatinine level was 0.86 mg / dl , with blood urea nitrogen of 10.1 mg / dl .
urinalysis showed red blood cell ( rbc ) 3 + and urinary sediment showed dysmorphic rbcs ( > 100/high power field ) with rbc casts and absence of white blood cells .
urine 2-microglobulin was 913 g / l , urine n - acetyl - beta - d - glucosaminidase was 14.9
the patient was subsequently diagnosed with pulmonary tuberculosis and was treated with a standard regimen including four drugs for 2 months , followed by isoniazid and rifampin for 4 months . because of persistent hematuria , the patient was hospitalized to undergo renal biopsy .
the histopathological analysis revealed focal interstitial infiltration of lymphocytes and plasma cells in the renal cortex as well as in the corticomedullary junction , accompanied by mild tubulitis without microcysts ( figure 1 ) .
no tubular necrosis was observed , with erythrocytic casts and flattened tubular epithelium ( figure 2 ) .
analysis of glomeruli showed no evidence of podocyte hypertrophy , glomerular collapse , or endocapillary hypercellularity ( figure 2 ) .
neelsen staining of the biopsied specimens was negative , and there were no pathological findings suggestive of tuberculosis .
two weeks after the initiation of treatment for tuberculosis , antiretroviral therapy ( art ) , including lamivudine , abacavir , and dolutegravir , was started .
eight months after the initiation of art , urinary levels of 2-microglobulin and n - acetyl - beta - d - glucosaminidase normalized and microscopic hematuria resolved completely .
the onset and diagnosis of interstitial nephritis occurred prior to initiation of art or any other medications , eliminating the possibility of it being drug induced .
inflammatory disorders such as immune reconstitution inflammatory syndrome and dils could not have been the cause of interstitial nephritis in the present case because art was started only after the onset of renal disease .
moreover , other infections were unlikely to be causes of interstitial nephritis , as there were no signs of infectious diseases other than hiv and tuberculosis .
hivan is the most common cause of renal dysfunction in patients with hiv , and only up to 10% of renal dysfunction is caused by interstitial nephritis.4,5 hivan is characterized by proteinuria , with histopathological changes such as focal and segmental glomerulosclerosis or collapsing or noncollapsing nephropathy .
however , diagnostic confirmation by kidney biopsy is often important , particularly when the typical proteinuria is not observed , and other diagnoses such as those related to diabetes or hypertension can be confirmed frequently by kidney biopsy.12,13 hivan frequently accompanies interstitial inflammation of the kidney,1417 but the lack of pathognomonic findings in glomeruli in the present case made hivan unlikely .
the lack of other glomerular changes such as podocyte hypertrophy and hyperplasia also contributed to excluding the diagnosis of hivan .
the pathogenesis of hiv - associated renal diseases , including hivan , has been thoroughly investigated , and the majority of current knowledge was gained from studies using animal models .
hiv-1 can infect renal epithelial cells through infected cd4 + lymphocytes , and viral proteins such as nef and vpr may have a synergistic role in inducing podocyte dysfunction .
this also leads to renal tubular epithelial cell apoptosis and tubulointerstitial inflammation , which results in one of unique histopathological changes of hivan.15,18,19 through survey of the literature , we were unable to find studies on the pathogenesis of interstitial nephritis associated with hiv .
whether similar pathophysiological observations related to tubulointerstitial inflammation observed in patients with hivan applies to our case remains unknown .
the optimal therapy for hiv - associated interstitial nephritis is unknown,4 but art is likely to be effective , as shown in the present case .
an early study suggested that corticosteroids may be beneficial for improving the inflammatory lesions of hivan,20 but this treatment regimen is not commonly prescribed in the era of art .
additionally , we can not confirm that the application of corticosteroids would be beneficial for hiv - associated pure interstitial nephritis . the exact incidence and morbidity of interstitial nephritis caused by hiv
physicians should be aware of the possibility , and kidney biopsies should be performed for differential diagnosis of interstitial nephritis .
we identified interstitial nephritis without glomerular lesions in a treatment - naive hiv - infected patient , which was considered to be a complication of hiv infection . to our knowledge , the occurrence of interstitial nephritis in hiv - infected patients without other etiologies is rare , given the lack of similar reports .
the findings presented herein are rare and should be further investigated to understand the potential role of interstitial nephritis on the prognosis of hiv infection .
 interstitial nephritis is a common cause of renal dysfunction . 
 it is primarily caused by drugs , infections , or autoimmune disorders . 
 patients with human immunodeficiency virus ( hiv ) infection can develop interstitial nephritis , although it typically occurs because of the aforementioned etiologies and not as a direct consequence of hiv infection . 
 interstitial lesions may occur in patients with hiv - associated nephropathy ( hivan ) . 
 however , interstitial nephritis without the glomerular injuries characteristic of hivan , and without the risk factors described earlier , is very rare . here , we describe a rare case of interstitial nephritis that was likely caused directly by hiv infection and not by other etiologies . 