parasitic infections are increasing worldwide due to rapid urbanization of cities , global warming , and international traveling .
the diagnosis of parasitic diseases of the respiratory system is challenging because clinical manifestation and radiological findings are not specific .
the larvae can cause airway inflammation , whereas migration of the mature adult worm may cause mechanical obstruction .
we present a case of interstitial pneumonitis caused by parasitic infestation , which was diagnosed on transbronchial lung biopsy ( tblb ) .
a 54-year - old female presented with a history of exertional breathlessness and dry cough for two months .
she was afebrile with spo2 of 91% on room air and bilateral crepitations on respiratory examination .
l ( 46.4% ) , fvc of 1.45 l ( 45.2% ) , and fev1/fvc 83% with reduction in dlco 1.46 mmol / min / kpa ( 18% ) and corrected value with alveolar volume 0.49 mmol / min / kpa ( 30% ) .
high - resolution computed tomography ( hrct ) of chest showed multiple ill - defined nodular opacities in both lung fields showing centrilobular distribution associated with ground glass opacities bilaterally .
fine reticular densities were seen at places with segments of traction bronchiectasis [ figure 1 ] .
total serum ige was 145 iu / ml and specific ige for pigeon droppings ( < 0.10
tblb showed thickened alveolar septa with mild lymphoplasmacytic inflammatory infiltrate in the interstitium with cross - sections of calcified parasitic larvae with foreign body giant cell reaction around it [ figure 2 ] .
travel history revealed frequent travels in the himalayan belts yearly for 20 years during which she had frequent episodes of diarrhea .
she was given albendazole 400 mg for three days and oral corticosteroids for 12 weeks .
bronchoalveolar lavage ( bal ) for tuberculosis culture at 6 weeks was negative . at 6 weeks
high - resolution computed tomography chest showing multiple ill - defined centrilobular opacities with ground glass opacities bilaterally before treatment histopathology image of transbronchial lung biopsy showing calcified larva with thickened alveolar septa with mild lymphoplasmacytic inflammatory infiltrate in the interstitium high - resolution computed tomography chest showing remarkable improvement after treatment
diffuse lung diseases can be further divided into transient pulmonary infiltrates and alveolar or interstitial lung diseases .
ascariasis , anchylostomiasis , and toxocariasis usually cause transient pulmonary infiltrates , whereas schistosomiasis , strongyloidiasis , and tropical pulmonary eosinophilia can cause diffuse interstitial changes , as in the current case .
strongyloidiasis causes reticulonodular opacities because of secondary infection , hemorrhage , inflammatory pneumonitis , and bacterial abscess formation .
schistosomiasis eggs that are not passed into bladder or intestinal lumen are the main cause of chronic lung diseases causing granulomatous reaction and fibrosis .
tropical pulmonary eosinophilia typically results from a hypersensitivity reaction to wuchereria bancrofti and brugia malayi .
tropical pulmonary eosinophilia is an immunological response to microfilariae rather than acute infection , which usually present as reticulonodular opacities .
the diagnosis of parasitic infections is difficult on chest radiography or hrct of chest because of nonspecific presentations .
bronchoscopy may be helpful for diagnosis of parasitic infestation by variety of ways like direct visualization , bal , brushing , and tblb .
parasitic lung diseases can also show microscopic pulmonary calcification on lung biopsy . in the current report ,
transbronchial lung biopsy revealed showed thickened alveolar septa with mild lymphoplasmacytic inflammatory infiltrate in the interstitium with cross - sections of calcified parasitic larvae .
tblb is performed for obtaining tissue specimen from peripheral lung masses and focal or diffuse lung infiltrates .
the technique is useful in patients with suspected lung cancer , fungal and mycobacterial lung infections , unexplained infiltrates in immunocompromised hosts and in patients with suspected pulmonary sarcoidosis , lymphangitic carcinomatosis , and in selected cases of pulmonary langerhan 's cell histiocytosis , lymphangioleiomyomatosis , and cryptogenic organizing pneumonia .
with increasing travels and worldwide migration , parasitic infections should be considered in differential diagnosis of interstitial lung diseases particularly in the evaluation of diffuse lung infiltrates .
bronchoscopy and transbronchial lung biopsy can be useful in the diagnosis of diffuse lung infiltrates .
 parasite infections are increasing worldwide due to increasing migration and traveling . 
 parasitic infections can affect lungs and present as a focal or diffuse lung diseases . 
 high index of suspicion and detailed history are most important . 
 we present a case of interstitial pneumonitis caused by parasite infestation , which was diagnosed on transbronchial lung biopsy . 