As vayne, Vayne shines during the late game as she can run down enemies due to her e and s. All she needs to do is to avoid getting CC'd.

A fully maxed out Ultimate n will give a massive power spike to Vayne. This is absolutely necessary to win the game and will allow Vayne to dish out tons of damage.

Vayne will have multiple items by now, which means that she will be hitting enemies like a truck. A defensive item should allow her to solidify her position as the primary carry of the team. As vayne, Vayne shines during the late part as she can run down the enemies due to her e and s. All she has to do is avoid getting CC'd. A maxed out Ultimate n will give Vayne a massive power peak. This is absolutely necessary to win the game and will allow Vayne to deposit tons of damage. Vayne will now have several items, which means she will hit enemies like a truck. A defensive element should allow her to solidify her position as the main port of the team.