Against vayne, Vayne’s first power spike is when she is level 6. Her kill pressure and manoeuvrability increases dramatically whenever her Ultimate n  is up.

Vayne is incredibly weak in the early game. Try to abuse this if you can.

End the game as fast as possible. Vayne is a late-game monster and will be incredibly hard to kill in the late game. Against vayne, Vayne is incredibly weak in the beginning of the game. Try to abuse it if you can. Finish the game as fast as possible. Vayne is a monster of the end of the game and will be incredibly hard to kill in the end of the game.