As malzahar, Malzahar’s first major power spike is when he gets his first component item. It will allow him to spam his abilities on the enemy laners. 

When Malzahar hits level 6, he can look for picks and set up kills for his ADC or the Jungler.

During the early game, Malzahar should try to use his Ultimate R whenever he can. Using it as soon as it comes up will help his lane get more kills and start a snowball.
 As malzahar, Malzahar's first major power peak is when he gets his first component. It will allow him to spam his abilities on enemy tires. When Malzahar reaches level 6, he can look for peaks and set up kills for his ADC or Jungler. During the early match, Malzahar should try to use his Ultimate R whenever he can.