We present recursive cascaded networks, a general architecture that enables learning deep cascades, for deformable image registration. The proposed architecture is simple in design and can be built on any base network. The moving image is warped successively by each cascade and finally aligned to the fixed image; this procedure is recursive in a way that every cascade learns to perform a progressive deformation for the current warped image. The entire system is end-to-end and jointly trained in an unsupervised manner. In addition, enabled by the recursive architecture, one cascade can be iteratively applied for multiple times during testing, which approaches a better fit between each of the image pairs. We evaluate our method on 3D medical images, where deformable registration is most commonly applied. We demonstrate that recursive cascaded networks achieve consistent, significant gains and outperform state-of-the-art methods. The performance reveals an increasing trend as long as more cascades are trained, while the limit is not observed. Our code will be made publicly available.
We propose a novel cascaded framework, namely deep deformation network (DDN), for localizing landmarks in non-rigid objects. The hallmarks of DDN are its incorporation of geometric constraints within a convolutional neural network (CNN) framework, ease and efficiency of training, as well as generality of application. A novel shape basis network (SBN) forms the first stage of the cascade, whereby landmarks are initialized by combining the benefits of CNN features and a learned shape basis to reduce the complexity of the highly nonlinear pose manifold. In the second stage, a point transformer network (PTN) estimates local deformation parameterized as thin-plate spline transformation for a finer refinement. Our framework does not incorporate either handcrafted features or part connectivity, which enables an end-to-end shape prediction pipeline during both training and testing. In contrast to prior cascaded networks for landmark localization that learn a mapping from feature space to landmark locations, we demonstrate that the regularization induced through geometric priors in the DDN makes it easier to train, yet produces superior results. The efficacy and generality of the architecture is demonstrated through state-of-the-art performances on several benchmarks for multiple tasks such as facial landmark localization, human body pose estimation and bird part localization. Inspired by recent advances in deep learning, we propose a framework for reconstructing dynamic sequences of 2-D cardiac magnetic resonance (MR) images from undersampled data using a deep cascade of convolutional neural networks (CNNs) to accelerate the data acquisition process. In particular, we address the case where data are acquired using aggressive Cartesian undersampling. First, we show that when each 2-D image frame is reconstructed independently, the proposed method outperforms state-of-the-art 2-D compressed sensing approaches, such as dictionary learning-based MR image reconstruction, in terms of reconstruction error and reconstruction speed. Second, when reconstructing the frames of the sequences jointly, we demonstrate that CNNs can learn spatio-temporal correlations efficiently by combining convolution and data sharing approaches. We show that the proposed method consistently outperforms state-of-the-art methods and is capable of preserving anatomical structure more faithfully up to 11-fold undersampling. Moreover, reconstruction is very fast: each complete dynamic sequence can be reconstructed in less than 10 s and, for the 2-D case, each image frame can be reconstructed in 23 ms, enabling real-time applications. In object detection, an intersection over union (IoU) threshold is required to define positives and negatives. An object detector, trained with low IoU threshold, e.g. 0.5, usually produces noisy detections. However, detection performance tends to degrade with increasing the IoU thresholds. Two main factors are responsible for this: 1) overfitting during training, due to exponentially vanishing positive samples, and 2) inference-time mismatch between the IoUs for which the detector is optimal and those of the input hypotheses. A multi-stage object detection architecture, the Cascade R-CNN, is proposed to address these problems. It consists of a sequence of detectors trained with increasing IoU thresholds, to be sequentially more selective against close false positives. The detectors are trained stage by stage, leveraging the observation that the output of a detector is a good distribution for training the next higher quality detector. The resampling of progressively improved hypotheses guarantees that all detectors have a positive set of examples of equivalent size, reducing the overfitting problem. The same cascade procedure is applied at inference, enabling a closer match between the hypotheses and the detector quality of each stage. A simple implementation of the Cascade R-CNN is shown to surpass all single-model object detectors on the challenging COCO dataset. Experiments also show that the Cascade R-CNN is widely applicable across detector architectures, achieving consistent gains independently of the baseline detector strength. The code is available at https: github.com zhaoweicai cascade-rcnn. 7T MRI scanner provides MR images with higher resolution and better contrast than 3T MR scanners. This helps many medical analysis tasks, including tissue segmentation. However, currently there is a very limited number of 7T MRI scanners worldwide. This motivates us to propose a novel image post-processing framework that can jointly generate high-resolution 7T-like images and their corresponding high-quality 7T-like tissue segmentation maps, solely from the routine 3T MR images. Our proposed framework comprises two parallel components, namely (1) reconstruction and (2) segmentation. The reconstruction component includes the multi-step cascaded convolutional neural networks (CNNs) that map the input 3T MR image to a 7T-like MR image, in terms of both resolution and contrast. Similarly, the segmentation component involves another paralleled cascaded CNNs, with a different architecture, to generate high-quality segmentation maps. These cascaded feedbacks between the two designed paralleled CNNs allow both tasks to mutually benefit from each another when learning the respective reconstruction and segmentation mappings. For evaluation, we have tested our framework on 15 subjects (with paired 3T and 7T images) using a leave-one-out cross-validation. The experimental results show that our estimated 7T-like images have richer anatomical details and better segmentation results, compared to the 3T MRI. Furthermore, our method also achieved better results in both reconstruction and segmentation tasks, compared to the state-of-the-art methods. Semantic segmentation has been popularly addressed using Fully convolutional networks (FCN) (e.g. U-Net) with impressive results and has been the forerunner in recent segmentation challenges. However, FCN approaches do not necessarily incorporate local geometry such as smoothness and shape, whereas traditional image analysis techniques have benefitted greatly by them in solving segmentation and tracking problems. In this work, we address the problem of incorporating shape priors within the FCN segmentation framework. We demonstrate the utility of such a shape prior in robust handling of scenarios such as loss of contrast and artifacts. Our experiments show ( 5 ) improvement over U-Net for the challenging problem of ultrasound kidney segmentation. The number of mitoses per tissue area gives an important aggressiveness indication of the invasive breast carcinoma. However, automatic mitosis detection in histology images remains a challenging problem. Traditional methods either employ hand-crafted features to discriminate mitoses from other cells or construct a pixel-wise classifier to label every pixel in a sliding window way. While the former suffers from the large shape variation of mitoses and the existence of many mimics with similar appearance, the slow speed of the later prohibits its use in clinical practice. In order to overcome these shortcomings, we propose a fast and accurate method to detect mitosis by designing a novel deep cascaded convolutional neural network, which is composed of two components. First, by leveraging the fully convolutional neural network, we propose a coarse retrieval model to identify and locate the candidates of mitosis while preserving a high sensitivity. Based on these candidates, a fine discrimination model utilizing knowledge transferred from cross-domain is developed to further single out mitoses from hard mimics. Our approach outperformed other methods by a large margin in 2014 ICPR MITOS-ATYPIA challenge in terms of detection accuracy. When compared with the state-of-the-art methods on the 2012 ICPR MITOSIS data (a smaller and less challenging dataset), our method achieved comparable or better results with a roughly 60 times faster speed. Semantic segmentation research has recently witnessed rapid progress, but many leading methods are unable to identify object instances. In this paper, we present Multitask Network Cascades for instance-aware semantic segmentation. Our model consists of three networks, respectively differentiating instances, estimating masks, and categorizing objects. These networks form a cascaded structure, and are designed to share their convolutional features. We develop an algorithm for the nontrivial end-to-end training of this causal, cascaded structure. Our solution is a clean, single-step training framework and can be generalized to cascades that have more stages. We demonstrate state-of-the-art instance-aware semantic segmentation accuracy on PASCAL VOC. Meanwhile, our method takes only 360ms testing an image using VGG-16, which is two orders of magnitude faster than previous systems for this challenging problem. As a by product, our method also achieves compelling object detection results which surpass the competitive Fast Faster R-CNN systems. The method described in this paper is the foundation of our submissions to the MS COCO 2015 segmentation competition, where we won the 1st place. In this paper, we propose a new model called deep network cascade (DNC) to gradually upscale low-resolution images layer by layer, each layer with a small scale factor. DNC is a cascade of multiple stacked collaborative local auto-encoders. In each layer of the cascade, non-local self-similarity search is first performed to enhance high-frequency texture details of the partitioned patches in the input image. The enhanced image patches are then input into a collaborative local auto-encoder (CLA) to suppress the noises as well as collaborate the compatibility of the overlapping patches. By closing the loop on non-local self-similarity search and CLA in a cascade layer, we can refine the super-resolution result, which is further fed into next layer until the required image scale. Experiments on image super-resolution demonstrate that the proposed DNC can gradually upscale a low-resolution image with the increase of network layers and achieve more promising results in visual quality as well as quantitative performance.