Image denoising is an important pre-processing step in medical image analysis. Different algorithms have been proposed in past three decades with varying denoising performances. More recently, having outperformed all conventional methods, deep learning based models have shown a great promise. These methods are however limited for requirement of large training sample size and high computational costs. In this paper we show that using small sample size, denoising autoencoders constructed using convolutional layers can be used for efficient denoising of medical images. Heterogeneous images can be combined to boost sample size for increased denoising performance. Simplest of networks can reconstruct images with corruption levels so high that noise and signal are not differentiable to human eye.
We present a novel approach to low-level vision problems that combines sparse coding and deep networks pre-trained with denoising auto-encoder (DA). We propose an alternative training scheme that successfully adapts DA, originally designed for unsupervised feature learning, to the tasks of image denoising and blind inpainting. Our method's performance in the image denoising task is comparable to that of KSVD which is a widely used sparse coding technique. More importantly, in blind image inpainting task, the proposed method provides solutions to some complex problems that have not been tackled before. Specifically, we can automatically remove complex patterns like superimposed text from an image, rather than simple patterns like pixels missing at random. Moreover, the proposed method does not need the information regarding the region that requires inpainting to be given a priori. Experimental results demonstrate the effectiveness of the proposed method in the tasks of image denoising and blind inpainting. We also show that our new training scheme for DA is more effective and can improve the performance of unsupervised feature learning. Image denoising can be described as the problem of mapping from a noisy image to a noise-free image. The best currently available denoising methods approximate this mapping with cleverly engineered algorithms. In this work we attempt to learn this mapping directly with a plain multi layer perceptron (MLP) applied to image patches. While this has been done before, we will show that by training on large image databases we are able to compete with the current state-of-the-art image denoising methods. Furthermore, our approach is easily adapted to less extensively studied types of noise (by merely exchanging the training data), for which we achieve excellent results as well. We propose a novel image denoising strategy based on an enhanced sparse representation in transform domain. The enhancement of the sparsity is achieved by grouping similar 2D image fragments (e.g., blocks) into 3D data arrays which we call "groups." Collaborative Altering is a special procedure developed to deal with these 3D groups. We realize it using the three successive steps: 3D transformation of a group, shrinkage of the transform spectrum, and inverse 3D transformation. The result is a 3D estimate that consists of the jointly filtered grouped image blocks. By attenuating the noise, the collaborative filtering reveals even the finest details shared by grouped blocks and, at the same time, it preserves the essential unique features of each individual block. The filtered blocks are then returned to their original positions. Because these blocks are overlapping, for each pixel, we obtain many different estimates which need to be combined. Aggregation is a particular averaging procedure which is exploited to take advantage of this redundancy. A significant improvement is obtained by a specially developed collaborative Wiener filtering. An algorithm based on this novel denoising strategy and its efficient implementation are presented in full detail; an extension to color-image denoising is also developed. The experimental results demonstrate that this computationally scalable algorithm achieves state-of-the-art denoising performance in terms of both peak signal-to-noise ratio and subjective visual quality. Stacked sparse denoising autoencoders (SSDAs) have recently been shown to be successful at removing noise from corrupted images. However, like most denoising techniques, the SSDA is not robust to variation in noise types beyond what it has seen during training. To address this limitation, we present the adaptive multi-column stacked sparse denoising autoencoder (AMC-SSDA), a novel technique of combining multiple SSDAs by (1) computing optimal column weights via solving a nonlinear optimization program and (2) training a separate network to predict the optimal weights. We eliminate the need to determine the type of noise, let alone its statistics, at test time and even show that the system can be robust to noise not seen in the training set. We show that state-of-the-art denoising performance can be achieved with a single system on a variety of different noise types. Additionally, we demonstrate the efficacy of AMC-SSDA as a preprocessing (denoising) algorithm by achieving strong classification performance on corrupted MNIST digits. Previous work has shown that the difficulties in learning deep generative or discriminative models can be overcome by an initial unsupervised learning step that maps inputs to useful intermediate representations. We introduce and motivate a new training principle for unsupervised learning of a representation based on the idea of making the learned representations robust to partial corruption of the input pattern. This approach can be used to train autoencoders, and these denoising autoencoders can be stacked to initialize deep architectures. The algorithm can be motivated from a manifold learning and information theoretic perspective or from a generative model perspective. Comparative experiments clearly show the surprising advantage of corrupting the input of autoencoders on a pattern classification benchmark suite. We present an approach to low-level vision that combines two main ideas: the use of convolutional networks as an image processing architecture and an unsupervised learning procedure that synthesizes training samples from specific noise models. We demonstrate this approach on the challenging problem of natural image denoising. Using a test set with a hundred natural images, we find that convolutional networks provide comparable and in some cases superior performance to state of the art wavelet and Markov random field (MRF) methods. Moreover, we find that a convolutional network offers similar performance in the blind de-noising setting as compared to other techniques in the non-blind setting. We also show how convolutional networks are mathematically related to MRF approaches by presenting a mean field theory for an MRF specially designed for image denoising. Although these approaches are related, convolutional networks avoid computational difficulties in MRF approaches that arise from probabilistic learning and inference. This makes it possible to learn image processing architectures that have a high degree of representational power (we train models with over 15,000 parameters), but whose computational expense is significantly less than that associated with inference in MRF approaches with even hundreds of parameters. We explore an original strategy for building deep networks, based on stacking layers of denoising autoencoders which are trained locally to denoise corrupted versions of their inputs. The resulting algorithm is a straightforward variation on the stacking of ordinary autoencoders. It is however shown on a benchmark of classification problems to yield significantly lower classification error, thus bridging the performance gap with deep belief networks (DBN), and in several cases surpassing it. Higher level representations learnt in this purely unsupervised fashion also help boost the performance of subsequent SVM classifiers. Qualitative experiments show that, contrary to ordinary autoencoders, denoising autoencoders are able to learn Gabor-like edge detectors from natural image patches and larger stroke detectors from digit images. This work clearly establishes the value of using a denoising criterion as a tractable unsupervised objective to guide the learning of useful higher level representations.