We consider the problem of detecting out-of-distribution (OOD) samples in deep reinforcement learning. In a value based reinforcement learning setting, we propose to use uncertainty estimation techniques directly on the agent's value estimating neural network to detect OOD samples. The focus of our work lies in analyzing the suitability of approximate Bayesian inference methods and related ensembling techniques that generate uncertainty estimates. Although prior work has shown that dropout-based variational inference techniques and bootstrap-based approaches can be used to model epistemic uncertainty, the suitability for detecting OOD samples in deep reinforcement learning remains an open question. Our results show that uncertainty estimation can be used to differentiate in- from out-of-distribution samples. Over the complete training process of the reinforcement learning agents, bootstrap-based approaches tend to produce more reliable epistemic uncertainty estimates, when compared to dropout-based approaches.
Obtaining models that capture imaging markers relevant for disease progression and treatment monitoring is challenging. Models are typically based on large amounts of data with annotated examples of known markers aiming at automating detection. High annotation effort and the limitation to a vocabulary of known markers limit the power of such approaches. Here, we perform unsupervised learning to identify anomalies in imaging data as candidates for markers. We propose AnoGAN, a deep convolutional generative adversarial network to learn a manifold of normal anatomical variability, accompanying a novel anomaly scoring scheme based on the mapping from image space to a latent space. Applied to new data, the model labels anomalies, and scores image patches indicating their fit into the learned distribution. Results on optical coherence tomography images of the retina demonstrate that the approach correctly identifies anomalous images, such as images containing retinal fluid or hyperreflective foci.