Many autonomous driving motion planners generate trajectories by optimizing a reward cost functional. Designing and tuning a high-performance reward cost functional for Level-4 autonomous driving vehicles with exposure to different driving conditions is challenging. Traditionally, reward cost functional tuning involves substantial human effort and time spent on both simulations and road tests. As the scenario becomes more complicated, tuning to improve the motion planner performance becomes increasingly difficult. To systematically solve this issue, we develop a data-driven auto-tuning framework based on the Apollo autonomous driving framework. The framework includes a novel rank-based conditional inverse reinforcement learning algorithm, an offline training strategy and an automatic method of collecting and labeling data. Our auto-tuning framework has the following advantages that make it suitable for tuning an autonomous driving motion planner. First, compared to that of most inverse reinforcement learning algorithms, our algorithm training is efficient and capable of being applied to different scenarios. Second, the offline training strategy offers a safe way to adjust the parameters before public road testing. Third, the expert driving data and information about the surrounding environment are collected and automatically labeled, which considerably reduces the manual effort. Finally, the motion planner tuned by the framework is examined via both simulation and public road testing and is shown to achieve good performance.
Objective—To evaluate the pharmacokinetics of a novel commercial formulation of ivermectin after administration to goats. Animals—6 healthy adult goats. Procedure—Ivermectin (200 μg kg) was initially administered IV to each goat, and plasma samples were obtained for 36 days. After a washout period of 3 weeks, each goat received a novel commercial formulation of ivermectin (200 μg kg) by SC injection. Plasma samples were then obtained for 42 days. Drug concentrations were quantified by use of high-performance liquid chromatography with fluorescence detection. Results—Pharmacokinetics of ivermectin after IV administration were best described by a 2-compartment open model; values for main compartmental variables included volume of distribution at a steady state (9.94 L kg), clearance (1.54 L kg d), and area under the plasma concentration-time curve (AUC; 143 [ng•d] mL). Values for the noncompartmental variables included mean residence time (7.37 days), AUC (153 [ng•d] mL), and clearance (1.43 L kg d). After ...  Recent research has shown the benefit of framing problems of imitation learning as solutions to Markov Decision Problems. This approach reduces learning to the problem of recovering a utility function that makes the behavior induced by a near-optimal policy closely mimic demonstrated behavior. In this work, we develop a probabilistic approach based on the principle of maximum entropy. Our approach provides a well-defined, globally normalized distribution over decision sequences, while providing the same performance guarantees as existing methods. We develop our technique in the context of modeling real-world navigation and driving behaviors where collected data is inherently noisy and imperfect. Our probabilistic approach enables modeling of route preferences as well as a powerful new approach to inferring destinations and routes based on partial trajectories. Imitation learning of sequential, goal-directed behavior by standard supervised techniques is often difficult. We frame learning such behaviors as a maximum margin structured prediction problem over a space of policies. In this approach, we learn mappings from features to cost so an optimal policy in an MDP with these cost mimics the expert's behavior. Further, we demonstrate a simple, provably efficient approach to structured maximum margin learning, based on the subgradient method, that leverages existing fast algorithms for inference. Although the technique is general, it is particularly relevant in problems where A* and dynamic programming approaches make learning policies tractable in problems beyond the limitations of a QP formulation. We demonstrate our approach applied to route planning for outdoor mobile robots, where the behavior a designer wishes a planner to execute is often clear, while specifying cost functions that engender this behavior is a much more difficult task. We consider learning in a Markov decision process where we are not explicitly given a reward function, but where instead we can observe an expert demonstrating the task that we want to learn to perform. This setting is useful in applications (such as the task of driving) where it may be difficult to write down an explicit reward function specifying exactly how different desiderata should be traded off. We think of the expert as trying to maximize a reward function that is expressible as a linear combination of known features, and give an algorithm for learning the task demonstrated by the expert. Our algorithm is based on using "inverse reinforcement learning" to try to recover the unknown reward function. We show that our algorithm terminates in a small number of iterations, and that even though we may never recover the expert's reward function, the policy output by the algorithm will attain performance close to that of the expert, where here performance is measured with respect to the expert's unknown reward function.