Deep convolutional neural networks have achieved great success in various applications. However, training an effective DNN model for a specific task is rather challenging because it requires a prior knowledge or experience to design the network architecture, repeated trial-and-error process to tune the parameters, and a large set of labeled data to train the model. In this paper, we propose to overcome these challenges by actively adapting a pre-trained model to a new task with less labeled examples. Specifically, the pre-trained model is iteratively fine tuned based on the most useful examples. The examples are actively selected based on a novel criterion, which jointly estimates the potential contribution of an instance on optimizing the feature representation as well as improving the classification model for the target task. On one hand, the pre-trained model brings plentiful information from its original task, avoiding redesign of the network architecture or training from scratch; and on the other hand, the labeling cost can be significantly reduced by active label querying. Experiments on multiple datasets and different pre-trained models demonstrate that the proposed approach can achieve cost-effective training of DNNs.
Intense interest in applying convolutional neural networks (CNNs) in biomedical image analysis is wide spread, but its success is impeded by the lack of large annotated datasets in biomedical imaging. Annotating biomedical images is not only tedious and time consuming, but also demanding of costly, specialty - oriented knowledge and skills, which are not easily accessible. To dramatically reduce annotation cost, this paper presents a novel method called AIFT (active, incremental fine-tuning) to naturally integrate active learning and transfer learning into a single framework. AIFT starts directly with a pre-trained CNN to seek worthy samples from the unannotated for annotation, and the (fine-tuned) CNN is further fine-tuned continuously by incorporating newly annotated samples in each iteration to enhance the CNNs performance incrementally. We have evaluated our method in three different biomedical imaging applications, demonstrating that the cost of annotation can be cut by at least half. This performance is attributed to the several advantages derived from the advanced active and incremental capability of our AIFT method.