Segmentation is a key step in analyzing and processing medical images. Due to the low fault tolerance in medical imaging, manual segmentation remains the de facto standard in this domain. Besides, efforts to automate the segmentation process often rely on large amounts of manually labeled data. While existing software supporting manual segmentation is rich in features and delivers accurate results, the necessary time to set it up and get comfortable using it can pose a hurdle for the collection of large datasets. This work introduces a client server based online environment, referred to as Studierfenster (this http URL), that can be used to perform manual segmentations directly in a web browser. The aim of providing this functionality in the form of a web application is to ease the collection of ground truth segmentation datasets. Providing a tool that is quickly accessible and usable on a broad range of devices, offers the potential to accelerate this process. The manual segmentation workflow of Studierfenster consists of dragging and dropping the input file into the browser window and slice-by-slice outlining the object under consideration. The final segmentation can then be exported as a file storing its contours and as a binary segmentation mask. In order to evaluate the usability of Studierfenster, a user study was performed. The user study resulted in a mean of 6.3 out of 7.0 possible points given by users, when asked about their overall impression of the tool. The evaluation also provides insights into the results achievable with the tool in practice, by presenting two ground truth segmentations performed by physicians.
We present the integration of the OpenIGTLink network protocol for image-guided therapy (IGT) with the medical prototyping platform MeVisLab. OpenIGTLink is a new, open, simple and extensible network communication protocol for IGT. The protocol provides a standardized mechanism to connect hardware and software by the transfer of coordinate transforms, images, and status messages. MeVisLab is a framework for the development of image processing algorithms and visualization and interaction methods, with a focus on medical imaging. The integration of OpenIGTLink into MeVisLab has been realized by developing a software module using the C++ programming language. As a result, researchers using MeVisLab can interface their software to hardware devices that already support the OpenIGTLink protocol, such as the NDI Aurora magnetic tracking system. In addition, the OpenIGTLink module can also be used to communicate directly with Slicer, a free, open source software package for visualization and image analysis. The integration has been tested with tracker clients available online and a real tracking system. Background—OpenIGTLink is a new, open, simple and extensible network communication protocol for image-guided therapy (IGT). The protocol provides a standardized mechanism to connect hardware and software by the transfer of coordinate transforms, images, and status messages. MeVisLab is a framework for the development of image processing algorithms and visualization and interaction methods, with a focus on medical imaging. Virtual Reality, an immersive technology that replicates an environment via computer-simulated reality, gets a lot of attention in the entertainment industry. However, VR has also great potential in other areas, like the medical domain, Examples are intervention planning, training and simulation. This is especially of use in medical operations, where an aesthetic outcome is important, like for facial surgeries. Alas, importing medical data into Virtual Reality devices is not necessarily trivial, in particular, when a direct connection to a proprietary application is desired. Moreover, most researcher do not build their medical applications from scratch, but rather leverage platforms like MeVisLab, MITK, OsiriX or 3D Slicer. These platforms have in common that they use libraries like ITK and VTK, and provide a convenient graphical interface. However, ITK and VTK do not support Virtual Reality directly. In this study, the usage of a Virtual Reality device for medical data under the MeVisLab platform is presented. The OpenVR library is integrated into the MeVisLab platform, allowing a direct and uncomplicated usage of the head mounted display HTC Vive inside the MeVisLab platform. Medical data coming from other MeVisLab modules can directly be connected per drag-and-drop to the Virtual Reality module, rendering the data inside the HTC Vive for immersive virtual reality inspection. Volumetric change in glioblastoma multiforme (GBM) over time is a critical factor in treatment decisions. Typically, the tumor volume is computed on a slice-by-slice basis using MRI scans obtained at regular intervals. (3D)Slicer – a free platform for biomedical research – provides an alternative to this manual slice-by-slice segmentation process, which is significantly faster and requires less user interaction. In this study, 4 physicians segmented GBMs in 10 patients, once using the competitive region-growing based GrowCut segmentation module of Slicer, and once purely by drawing boundaries completely manually on a slice-by-slice basis. Furthermore, we provide a variability analysis for three physicians for 12 GBMs. The time required for GrowCut segmentation was on an average 61 of the time required for a pure manual segmentation. A comparison of Slicer-based segmentation with manual slice-by-slice segmentation resulted in a Dice Similarity Coefficient of 88.43 ± 5.23 and a Hausdorff Distance of 2.32 ± 5.23 mm.