A key challenge in complex visuomotor control is learning abstract representations that are effective for specifying goals, planning, and generalization. To this end, we introduce universal planning networks (UPN). UPNs embed differentiable planning within a goal-directed policy. This planning computation unrolls a forward model in a latent space and infers an optimal action plan through gradient descent trajectory optimization. The plan-by-gradient-descent process and its underlying representations are learned end-to-end to directly optimize a supervised imitation learning objective. We find that the representations learned are not only effective for goal-directed visual imitation via gradient-based trajectory optimization, but can also provide a metric for specifying goals using images. The learned representations can be leveraged to specify distance-based rewards to reach new target states for model-free reinforcement learning, resulting in substantially more effective learning when solving new tasks described via image-based goals. We were able to achieve successful transfer of visuomotor planning strategies across robots with significantly different morphologies and actuation capabilities.
Objective—To evaluate the pharmacokinetics of a novel commercial formulation of ivermectin after administration to goats. Animals—6 healthy adult goats. Procedure—Ivermectin (200 μg kg) was initially administered IV to each goat, and plasma samples were obtained for 36 days. After a washout period of 3 weeks, each goat received a novel commercial formulation of ivermectin (200 μg kg) by SC injection. Plasma samples were then obtained for 42 days. Drug concentrations were quantified by use of high-performance liquid chromatography with fluorescence detection. Results—Pharmacokinetics of ivermectin after IV administration were best described by a 2-compartment open model; values for main compartmental variables included volume of distribution at a steady state (9.94 L kg), clearance (1.54 L kg d), and area under the plasma concentration-time curve (AUC; 143 [ng•d] mL). Values for the noncompartmental variables included mean residence time (7.37 days), AUC (153 [ng•d] mL), and clearance (1.43 L kg d). After ...  In this paper we investigate the use of MPC-inspired neural network policies for sequential decision making. We introduce an extension to the DAgger algorithm for training such policies and show how they have improved training performance and generalization capabilities. We take advantage of this extension to show scalable and efficient training of complex planning policy architectures in continuous state and action spaces. We provide an extensive comparison of neural network policies by considering feed forward policies, recurrent policies, and recurrent policies with planning structure inspired by the Path Integral control framework. Our results suggest that MPC-type recurrent policies have better robustness to disturbances and modeling error. Reinforcement learning can acquire complex behaviors from high-level specifications. However, defining a cost function that can be optimized effectively and encodes the correct task is challenging in practice. We explore how inverse optimal control (IOC) can be used to learn behaviors from demonstrations, with applications to torque control of high-dimensional robotic systems. Our method addresses two key challenges in inverse optimal control: first, the need for informative features and effective regularization to impose structure on the cost, and second, the difficulty of learning the cost function under unknown dynamics for high-dimensional continuous systems. To address the former challenge, we present an algorithm capable of learning arbitrary nonlinear cost functions, such as neural networks, without meticulous feature engineering. To address the latter challenge, we formulate an efficient sample-based approximation for MaxEnt IOC. We evaluate our method on a series of simulated tasks and real-world robotic manipulation problems, demonstrating substantial improvement over prior methods both in terms of task complexity and sample efficiency.  Consider learning a policy from example expert behavior, without interaction with the expert or access to reinforcement signal. One approach is to recover the expert's cost function with inverse reinforcement learning, then extract a policy from that cost function with reinforcement learning. This approach is indirect and can be slow. We propose a new general framework for directly extracting a policy from data, as if it were obtained by reinforcement learning following inverse reinforcement learning. We show that a certain instantiation of our framework draws an analogy between imitation learning and generative adversarial networks, from which we derive a model-free imitation learning algorithm that obtains significant performance gains over existing model-free methods in imitating complex behaviors in large, high-dimensional environments.  Recent advances have shown the capability of Fully Convolutional Neural Networks (FCN) to model cost functions for motion planning in the context of learning driving preferences purely based on demonstration data from human drivers. While pure learning from demonstrations in the framework of Inverse Reinforcement Learning (IRL) is a promising approach, we can benefit from well informed human priors and incorporate them into the learning process. Our work achieves this by pretraining a model to regress to a manual cost function and refining it based on Maximum Entropy Deep Inverse Reinforcement Learning. When injecting prior knowledge as pretraining for the network, we achieve higher robustness, more visually distinct obstacle boundaries, and the ability to capture instances of obstacles that elude models that purely learn from demonstration data. Furthermore, by exploiting these human priors, the resulting model can more accurately handle corner cases that are scarcely seen in the demonstration data, such as stairs, slopes, and underpasses.