While clustering is one of the most popular methods for data mining, analysts lack adequate tools for quick, iterative clustering analysis, which is essential for hypothesis generation and data reasoning. We introduce Clustrophile, an interactive tool for iteratively computing discrete and continuous data clusters, rapidly exploring different choices of clustering parameters, and reasoning about clustering instances in relation to data dimensions. Clustrophile combines three basic visualizations -- a table of raw datasets, a scatter plot of planar projections, and a matrix diagram (heatmap) of discrete clusterings -- through interaction and intermediate visual encoding. Clustrophile also contributes two spatial interaction techniques, @math and @math , and a visualization method, @math , for reasoning about two-dimensional projections obtained through dimensionality reductions.
To date, work in microarrays, sequenced genomes and bioinformatics has focused largely on algorithmic methods for processing and manipulating vast biological data sets. Future improvements will likely provide users with guidance in selecting the most appropriate algorithms and metrics for identifying meaningful clusters-interesting patterns in large data sets, such as groups of genes with similar profiles. Hierarchical clustering has been shown to be effective in microarray data analysis for identifying genes with similar profiles and thus possibly with similar functions. Users also need an efficient visualization tool, however, to facilitate pattern extraction from microarray data sets. The Hierarchical Clustering Explorer integrates four interactive features to provide information visualization techniques that allow users to control the processes and interact with the results. Thus, hybrid approaches that combine powerful algorithms with interactive visualization tools will join the strengths of fast processors with the detailed understanding of domain experts.