We propose a new family of combinatorial inference problems for graphical models. Unlike classical statistical inference where the main interest is point estimation or parameter testing, combinatorial inference aims at testing the global structure of the underlying graph. Examples include testing the graph connectivity, the presence of a cycle of certain size, or the maximum degree of the graph. To begin with, we develop a unified theory for the fundamental limits of a large family of combinatorial inference problems. We propose new concepts including structural packing and buffer entropies to characterize how the complexity of combinatorial graph structures impacts the corresponding minimax lower bounds. On the other hand, we propose a family of novel and practical structural testing algorithms to match the lower bounds. We provide thorough numerical results on both synthetic graphical models and brain networks to illustrate the usefulness of these proposed methods.
The problem of graphical model selection is to estimate the graph structure of a Markov random field given samples from it. We analyze the information-theoretic limitations of the problem of graph selection for binary Markov random fields under high-dimensional scaling, in which the graph size and the number of edges k, and or the maximal node degree d, are allowed to increase to infinity as a function of the sample size n. For pair-wise binary Markov random fields, we derive both necessary and sufficient conditions for correct graph selection over the class Gp,k of graphs on vertices with at most k edges, and over the class Gp,d of graphs on p vertices with maximum degree at most d. For the class Gp,k, we establish the existence of constants c and c' such that if n ; c' k2 log p. Similarly, for the class Gp,d, we exhibit constants c and c' such that for n ; c' d3 log p.  The Gaussian graphical model, a popular paradigm for studying relationship among variables in a wide range of applications, has attracted great attention in recent years. This paper considers a fundamental question: When is it possible to estimate low-dimensional parameters at parametric square-root rate in a large Gaussian graphical model? A novel regression approach is proposed to obtain asymptotically efficient estimation of each entry of a precision matrix under a sparseness condition relative to the sample size. When the precision matrix is not sufficiently sparse, or equivalently the sample size is not sufficiently large, a lower bound is established to show that it is no longer possible to achieve the parametric rate in the estimation of each entry. This lower bound result, which provides an answer to the delicate sample size question, is established with a novel construction of a subset of sparse precision matrices in an application of Le Cam's lemma. Moreover, the proposed estimator is proven to have optimal convergence rate when the parametric rate cannot be achieved, under a minimal sample requirement. The proposed estimator is applied to test the presence of an edge in the Gaussian graphical model or to recover the support of the entire model, to obtain adaptive rate-optimal estimation of the entire precision matrix as measured by the matrix @math operator norm and to make inference in latent variables in the graphical model. All of this is achieved under a sparsity condition on the precision matrix and a side condition on the range of its spectrum. This significantly relaxes the commonly imposed uniform signal strength condition on the precision matrix, irrepresentability condition on the Hessian tensor operator of the covariance matrix or the @math constraint on the precision matrix. Numerical results confirm our theoretical findings. The ROC curve of the proposed algorithm, Asymptotic Normal Thresholding (ANT), for support recovery significantly outperforms that of the popular GLasso algorithm.