Due to physiological variation, patients diagnosed with the same condition may exhibit divergent, but related, responses to the same treatments. Hidden Parameter Markov Decision Processes (HiP-MDPs) tackle this transfer-learning problem by embedding these tasks into a low-dimensional space. However, the original formulation of HiP-MDP had a critical flaw: the embedding uncertainty was modeled independently of the agent's state uncertainty, requiring an unnatural training procedure in which all tasks visited every part of the state space---possible for robots that can be moved to a particular location, impossible for human patients. We update the HiP-MDP framework and extend it to more robustly develop personalized medicine strategies for HIV treatment.
Rich and complex time-series data, such as those generated from engineering systems, financial markets, videos, or neural recordings are now a common feature of modern data analysis. Explaining the phenomena underlying these diverse data sets requires flexible and accurate models. In this paper, we promote Gaussian process dynamical systems as a rich model class that is appropriate for such an analysis. We present a new approximate message-passing algorithm for Bayesian state estimation and inference in Gaussian process dynamical systems, a non-parametric probabilistic generalization of commonly used state-space models. We derive our message-passing algorithm using Expectation Propagation and provide a unifying perspective on message passing in general state-space models. We show that existing Gaussian filters and smoothers appear as special cases within our inference framework, and that these existing approaches can be improved upon using iterated message passing. Using both synthetic and real-world data, we demonstrate that iterated message passing can improve inference in a wide range of tasks in Bayesian state estimation, thus leading to improved predictions and more effective decision making. We exploit some useful properties of Gaussian process (GP) regression models for reinforcement learning in continuous state spaces and discrete time. We demonstrate how the GP model allows evaluation of the value function in closed form. The resulting policy iteration algorithm is demonstrated on a simple problem with a two dimensional state space. Further, we speculate that the intrinsic ability of GP models to characterise distributions of functions would allow the method to capture entire distributions over future values instead of merely their expectation, which has traditionally been the focus of much of reinforcement learning.  In this paper, we introduce PILCO, a practical, data-efficient model-based policy search method. PILCO reduces model bias, one of the key problems of model-based reinforcement learning, in a principled way. By learning a probabilistic dynamics model and explicitly incorporating model uncertainty into long-term planning, PILCO can cope with very little data and facilitates learning from scratch in only a few trials. Policy evaluation is performed in closed form using state-of-the-art approximate inference. Furthermore, policy gradients are computed analytically for policy improvement. We report unprecedented learning efficiency on challenging and high-dimensional control tasks.   In this paper, we bring techniques from operations research to bear on the problem of choosing optimal actions in partially observable stochastic domains. We begin by introducing the theory of Markov decision processes (mdps) and partially observable MDPs (pomdps). We then outline a novel algorithm for solving pomdps off line and show how, in some cases, a finite-memory controller can be extracted from the solution to a POMDP. We conclude with a discussion of how our approach relates to previous work, the complexity of finding exact solutions to pomdps, and of some possibilities for finding approximate solutions.  In this paper we introduce a new underlying probabilistic model for principal component analysis (PCA). Our formulation interprets PCA as a particular Gaussian process prior on a mapping from a latent space to the observed data-space. We show that if the prior's covariance function constrains the mappings to be linear the model is equivalent to PCA, we then extend the model by considering less restrictive covariance functions which allow non-linear mappings. This more general Gaussian process latent variable model (GPLVM) is then evaluated as an approach to the visualisation of high dimensional data for three different data-sets. Additionally our non-linear algorithm can be further kernelised leading to 'twin kernel PCA' in which a mapping between feature spaces occurs.