Radiomics is a term which refers to the analysis of the large amount of quantitative tumor features extracted from medical images to find useful predictive, diagnostic or prognostic information. Many recent studies have proved that radiomics can offer a lot of useful information that physicians cannot extract from the medical images and can be associated with other information like gene or protein data. However, most of the classification studies in radiomics report the use of feature selection methods without identifying the machine learning challenges behind radiomics. In this paper, we first show that the radiomics problem should be viewed as an high dimensional, low sample size, multi view learning problem, then we compare different solutions proposed in multi view learning for classifying radiomics data. Our experiments, conducted on several real world multi view datasets, show that the intermediate integration methods work significantly better than filter and embedded feature selection methods commonly used in radiomics.
In recent years, a great many methods of learning from multi-view data by considering the diversity of different views have been proposed. These views may be obtained from multiple sources or different feature subsets. In trying to organize and highlight similarities and differences between the variety of multi-view learning approaches, we review a number of representative multi-view learning algorithms in different areas and classify them into three groups: 1) co-training, 2) multiple kernel learning, and 3) subspace learning. Notably, co-training style algorithms train alternately to maximize the mutual agreement on two distinct views of the data; multiple kernel learning algorithms exploit kernels that naturally correspond to different views and combine kernels either linearly or non-linearly to improve learning performance; and subspace learning algorithms aim to obtain a latent subspace shared by multiple views by assuming that the input views are generated from this latent subspace. Though there is significant variance in the approaches to integrating multiple views to improve learning performance, they mainly exploit either the consensus principle or the complementary principle to ensure the success of multi-view learning. Since accessing multiple views is the fundament of multi-view learning, with the exception of study on learning a model from multiple views, it is also valuable to study how to construct multiple views and how to evaluate these views. Overall, by exploring the consistency and complementary properties of different views, multi-view learning is rendered more effective, more promising, and has better generalization ability than single-view learning.