Difficulties, obstacles, challenges, hardships, struggles, pain, setbacks, frustration, disappointment, exhaustion, confusion, uncertainty, failures, setbacks, dark times, despair, hopelessness, stress, anxiety, mistakes, regrets, self-doubt, loss, sadness, grief, loneliness, isolation, weariness, hardship, suffering, trials, tribulations, adversity, uphill battle, hurdles, stumbling blocks, setbacks, defeats, heartbreak, sacrifice, frustration, exhaustion, setbacks, wrong choices, missed opportunities, setbacks.