Objective: The objectives of the study were to assess and evaluate the knowledge before and after administration of client volunteer teaching and find out the association of knowledge of tuberculosis patient with selected variable. Methodology: Quasi-experimental research approach with one group pre-test and post test design was used and 100 respondents were selected by purposive sampling technique in selected DOTS centre of Ambala, Haryana. The content reliability for structured knowledge questionnaire was formulated by Kuder- Richardon 20(Kr -20) i.e 0.83. Result: The mean of structured knowledge questionnaire before and after administration of client volunteer teaching was 13 and 16.23 respectively. where as In the area wise were knowledge score: the highest of pre-test score was in the area of concept of tuberculosis, risk factors and causes (51.37%) and post test score in the area of Investigation, treatment and prevention (45%). Further the finding shows Knowledge with residence (2. 710), ventilation (3.76) and lightening (3.39) and age (3.15), Type of house (2.103), BCG (2.406), were found statistically significant at 0.05 level of significance respectively. Discussion: In the present study, mean post test knowledge score (16.23±3.73) was higher than mean pre test knowledge scores (13.00 ± 4.00). Nearly similar types of finding were reported by Raman lal patidar that the total mean pre –test score 52.73% and post –test score 81.05% which shows the increase in post test knowledge. Conclusion: The study concluded that the client volunteer teaching was effective in improving the knowledge of the tuberculosis patient.