January 5 - Felix Manz, co-founder of the Swiss Anabaptists, was drowned in the Limmat River in Zurich by the Zurich Reformed state church.
May 16 - Florentines drive out the Medici for a second time and Florence re-establishes a republic.
Battle of Tokay - Ferdinand of Austria defeats John Zapolya and takes over most of Hungary. John appeals to the Turks for help.