Scientists in Canada have made DNA cubes that are programmed to unzip and reveal molecules locked inside them in response to a carefully chosen trigger. Hanadi Sleiman and colleagues at McGill University and the Jewish General Hospital in Montreal, designed the cubes to release the drug cargo they might be carrying only in diseased cells and not normal cells.
The DNA cube was also modified with hydrophobic and hydrophilic chains to modulate its cellular uptake and prevent enzymatic degradation.
‘Compared with previous DNA origami-based designs the present system does not rely on the use of M13 [bacteriophage] DNA and can therefore be applied to many targets,’ comments Hiroshi Sugiyama, a DNA nanotechnology expert at Kyoto University in Japan.
Next the team hope to demonstrate the encapsulation and release of sensitive oligonucleotide drugs, such as siRNA, using their new DNA platform.