Hello, DirWig You can indeed. The management port is its own NIC. It's impossible to use iSCSI on the management NICs for these, so there will be no interruption on the iSCSI if you were to change the IPs. You can disconnect them, change them, whatever you want to the management ports without interruption on the iSCSI network. 
I need to change the IP address for the management interface only (due to subnet conflict with company merge).  Can I do that without interruption to the storage access via iSCSI from the guest servers? Thanks,
Changing the Management IP on a PowerVault MD3220i