Hello,   You can use HIT/ME inside a VM providing that you are using the MS iSCSI initiator inside that VM to directly access EQL volumes formatted with the NTFS.   This is known as "Storage Direct".   In that case as far as the software is concerned is a physical host.   You will need two virtual nics in the guest, and two Virtual Machine Portgroups to properly configure MPIO as well.  If possible use dedicated NICs for this guest iSCSI, especially if you are using 1x GbE NICs.   On each portgroup, set one physical nic active and the other standby.  Reverse the order for the other Virtual Machine Portgroup.   This is not to be confused with configuring the ESXi iSCSI initiator VMkernel ports.   There some more info about Storage Direct in the TR1091 tech report on best practices with ESXi and EQL storage.   Regards, 
I got a suggestion in a thread last week to use HIT/ME ASM for my MS 2008 R2 iscsi data volumes, but I didn't make it clear that all of the 2008 servers are VMs in VMWare 5.5. Does HIT/ME still apply? All of the documentation and forum posts I've seen so far seem to indicate this is for Hyper-V hosts or bare metal servers. I realize there is a VMWare HIT appliance for the VM snapshots, so I will be setting that up. If the HIT/ME tool isn't for my VMs, I'll just keep using the built in EQ snapshot schedule. Thanks.
HIT/ME on VMWare MS guests