Hello dallasdunaway That shouldn't work, but populating them in 1,2,3 should work. If the memory is the same type(UDIMM/RDIMM) then you should also be able to put the 4GB DIMMs in 4,5,6. Thanks
currently, we have 6X4GB sticks of RAM for a total of 24GB.  I would like to upgrade, and I found 3x16GB RAM for a decent price and a total of 48GB.  Can I install 3 16GB sticks in sockets 1, 3, and 5 leaving sockets 2,4, and 6 blank?
RAM Upgrade questions...Poweredge R610