Yes, as long as the PC video out ports are USB-C and DP. Any usage of HDMI, DVI, or VGA will not work with DP MST daisy chain. #1 PC USB-C out port --> U2422HE USB-C to USB-C cable --> U2422HE #6 USB-C upstream port (video + data) (Menu- Display- MST on)U2422HE #7 DP out port --> U2422HE DP to DP cable --> U2422H #4 DP in port [IMAGE]   #2 PC DP out port --> U2422H DP to DP cable --> U2422HE #4 DP in port (Menu- Display- MST on)U2422HE #7 DP out port --> retail DP to DP cable --> U2422H #4 DP in portU2422HE #8 USB-C upstream port (data only) --> U2422HE USB-C to USB-A cable --> U2422H USB-A downstream port [IMAGE]
Hi I consider this combination. Two PC connected to monitor U2422HE and to this monitor is connected another one U2422H (simpler model) through MKS(Daisy chain). Will this combination work? KVM switch in U2422HE won't have problem with 2 monitors and switch them both? 
U2422HE + U2422H + two PC