VieiraR, If you want VLAN 80 to pass as tagged traffic then yes you will need to make sure that VLAN 80- exist on both switches and then general mode with "switchport general allowed vlan add 80 tagged"On the S-series if it is: OS9 then you'll need to add port-channel 1 as tagged for VLAN 80 OS10 then switchport mode trunk with command "switchport trunk allow vlan 80"
I need some advice in making a config change to a Port-Channel that is currently setup in Access Mode. This network was setup by another Network Admin before my Company Acquired them. Let me explain to the best I can how the current Setup is..... I created a new VLAN 80 on Switch 1 and 2. However, it does not route because there is no Patch for this VLAN between the Switches. If I change Po1 on Switch 1 to a General Switchport and make VLAN 50 its pvid and allow Tagged VLAN 80 over will this cause any issues? I also will need to make a change to Switch 2 PO1 allowing VLAN 80 over it too.  The only other option is to create an Access VLAN 80 Port Channel on each Switch and connect them. 
SwtichPort Access vs General