Open IE, change to the size/position desired, then choose File>Exit.  This should save window size/position information.
Recently whenever I open a WEB site using either IE or a shortcut on my desktop, the page that opens is about 1/3 the size of my screen instead of full size like it was in the past... I have tried full page under tools once oped and then it is ok.. but the next time I open a WEB site again using IE or a desktop short the size is small again.   Something has changed but what and how do I fix this?  I am using Vista.. 
IE Windows atarted coming up smaller