Recently acquired meaning there was not anything on this system you need to save.  Why not start with a fresh setup for both hardware and software. Cloning is making an identical image of partitions.  Bit for bit, block for block.  After replacing the original drive, a cloned drive will have drive C assigned. When you boot with and use file explorer from original drive, it will assign drive letter to each drive/partition in the system.  When you installed and boot with the cloned drive, operating system from the cloned drive will in turn, assign drive letter to each drive/partition in the system.  The operating system drive will self assigned as drive C to the drive being used.  So the drive letter is not a problem. The answer to your thread is still stand, if you cloned your system drive properly and swap it out, the new cloned drive should boot and work just like the original drive.  If it does not, you need to verify if it was cloned properly, or if any incorrect BIOS settings change was made after the cloning process.
I have a Precision 690, made around 2007 that I want to upgrade the smaller HDD to a 2 TB SSD.  I cloned the old drive just fine and it shows up as the E drive now, I can access it with no problems.  I changed the boot order in the BIOS so that it would boot from the SSD.  Upon restart the usual boot messages appear, but it gets to the "Serial ATA AHCI Bios" followed by "AHCI Bios installed"  and thats it - nothing loads past that point.  What am I missing here?  What do I need to do so that it will boot properly from the SSD?    The SSD is plugged into the motherboard SATA 0.
Precision 690 upgrade to SSD won't boot - Help Please