I was able to solve the problem and the solution was ... none of the above : )  Turns out that a user space application, splice.exe, (music software) was going nuts in the background and attempting to open  a lot of connections. After a few minutes this caused port exhaustion. I disabled splice and the now the internet connection is back to normal. Given the terrible reputation and performance of the Killer WiFi drivers, it was correct to assume they were the problem. In this case anyway, they were not the primary cause. It's possible they contributed to the problem in some way, but splice was the culprit. Thanks to Tesla1856 for offering advice as I worked through this.
When I boot my Alienware M15 R4 with AX1650 Wifi drivers, the internet connection works very briefly - only a few minutes.  However, the problem I am experiencing seems different than what other users have reported.  Here are the symptoms: 1. The issue affects, Killer Wifi,  Killer Ethernet, AND even a 3 party Thumbdrive Wifi card.  It is not limited to Killer Wifi. 2. The problem is the same across all three - a minute or two of internet access then most websites are no longer accessible. 3. Strangely,  YouTube and Spotify (both streaming services) seem the least affected and work OK.  But they are not immune from drops outs.  I mention this because I've seen references to Killer Wifi being optimized for gaming or streaming. 4.  The driver is up to date.  Currently it version 22.130.0.5.  The driver date is 3.15.2022.  Problems started in the last few weeks. 5.  Don't know if its related but this laptop has very short battery life.  Maybe one hour before it starts warning you it needs to be recharged.  If anyone has experienced these issues, I would appreciate your help.  I have done just about everything I have found online to include "network reset", turning off and then turning on the drivers;  various IPCONFIG and NETSH commands, and even using an external wifi card.  The symptoms are the same.
m15 R4, problem with Killer AX1650w WiFi drivers