"Anyone have an idea why the rear USB 3.x ports would work but none of the front USB 3.x ports or rear USB 2 ports?" They are actually different. The rear ports are USB 3.1 Gen 2, twice as fast (10 Gbps) as the front ones which are USB 3.1 Gen 1 (5 Gbps).  Also, they are served by a different USB host controller.
MY R10 is about one month old. Suddenly out of the blue, all the USB ports randomly disconnect and reconnect. My AW 510 Keyboard turns off and reboots mid sentence, and I can hear all the sounds that occur when the USB ports disconnect and reconnect. Peripherals also shut down. This happens randomly sometimes every few minutes. I set up a custom power scheme in Windows 10 that disables USB power turning off. But it does not seem to hold, and even when I am pretty sure its active, it does not stop the USB disconnecting and reconnecting. If I choose the scheme in Windows and if I go into AWCC the scheme is not listed as active with a green bar next to it. If I choose it in AWCC and click save, it does not save as the active scheme.  In fact just going into AWCC deselects the power scheme from Windows 10 that I had set previously; after entering AWCC Power settings, when I look in Windows I see the scheme has change, usually back to balanced. All this seems to have started after upgrading my BIOS to 2.1.3. I will call Alienware support tomorrow, but I am wondering if anyone else is noticing this problem lately to make me think this could be a BIOS issue. So I do not know if this is a power scheme issue, computer issue, AWCC issue or what but it is sure a problem, Greg
Aurora R10, AMD 5900X, USBs disconnecting