Single Initiator with Single Target is nearly always best practice.  In some cases, ports that can act as initiators or targets (i.e. MirrorView ports, for example) could accidentally log into each other if there were in a single initiator, multi-target zone.  There's seldom any performance impacts, just usability and cleanup.  Let us know if that helps!  Karl
Hi As of now we are using zoning with single initiator and multiple targets. We have both Dell Compellent and EMC VNX 5200 storage. With Compellent we are using virtual interfaces against each physical ports / wwns and DELL recommended to use all four virtual interfaces as target in a zone. With EMC SAN and MDS we are confused to go with "single initiator with single target" or "single initiator with multiple target" option. Is there performance impact or load for single initiator with multiple target option or is a just a best practice ?  Thanks in advance
Single Initiator and Single Target Zoning