Hi RMC,       With a RAID 5 RAID level in this case the answer would be no. You would have data loss or unavailability. This is because of the Dynamic pool architecture; there would be certain extents that would rely on those two drives to where you would lose an entire RAID set. This could effectively take the entire pool down as well.  Thanks
Unity 500F Storage Array. Pool1 12+1 (14 SSD disks drives). Can I lose more than one disk drive at the same time in the Pool without losing any data?
Pool Drive Failure