Probably not. It is too big, requires 2 slots and a 650W PSU. See for yourself-- your specs--See the list of cards that work. The card specs.    
Does anyone know if the Geforce RTX 2080 will fit inside the X51 R2? I Currently have a AMD R9 270 and an Intel i7-4600, so I figured it was time for an upgrade. I also have a 330W Power brick as well. Thank you in advance
X51 R2, Geforce RTX 2080 upgrade?