Dears  Finally I removed the EMC Powerpath and enabled MPIO and tested the LUN it was working fine.  Thankyou for the valuable feedback.
Dears  Our Environment consist of 2 node Hyper-V Cluster with AX4 shared storage.  Presently we have enable EMC Powerpath(Free for AX4)  and we are planning to connect the VNX 5300 to this cluster , Hence I believe the current EMC powerpath will not support VNX 5300 .  Hence How could I remove the EMC powerpath and enable MPIO  OR  Can I just leave the EMC powerpath  and continue to work ( we will be discarding the AX4 after the data is migrated)  Kindly advice.
How to disable EMC Powerpath