  Update and better news. Fn+Esc has worked to return my F1 - F12 keys to normal function. CTRL+F4 now closes a doc in Word or Excel, and ALT+F4 now closes (exits from) Word or Excel,, in both cases with no need to hit the Fn key. I have not inspected the new (to me) BIOSes for any kind of related POST election, but as of now, there is no need. I'm dismayed that Dell set these wireless keyboards to require the Fn key for normal F1 - F12 operation (and without any warning or literature anywhere, including on Dell's web sites), and it took a big chunk of four days (and most of this summer weekend) to get to the bottom of this, but at least and at last I made progress.  Since we've spent approx. $6,000 on our three new PCs, I am quite angry about it. In so many ways, Dell just can't help its customers who didn't spend eight years in college studying computers, even if we did spend fourteen + years on our own pickling up needed skills.  I'm happy to have made progress on this issue, but really frustrated by a complete lack of ergonomic thinking by Dell. This might also have helped with my second issue, at [URL]    
Just got three new Dell PCs - one Precision 3660 Tower and two Optiplex 7000 Towers.  Per my orders, all three came with the Dell wireless keyboard and mouse model KM5221W (the box label says KM5221WBKB-US). On all three, in order to use the normal F1 through F12 keys, I must also hold down the Fn key. For example, to close a document in Word, hitting only CTRL + F4 does not work.  Instead, I need to do Fn + CTRL + F4. This is way wrong. How do I reverse this situation? According to How-To Geek, there should be an "Fn Lock" option that is the same as holding the Fn key down all the time.  See [URL]  Will this work on my Dell?  How exactly do I try this Fn Lock on my Pcs and this model keyboard? Thanks.
How to do Fn Lock on Dell Wireless Keyboard KM5221W so F1 - F12 keys work 
normally?