You certainly can.  To expand on what Jupiter_7 listed, here is what I did to get it where I was happy.  I removed the power supply shroud for clearance, then vinyl wrapped the power supply housing since the silver was funky.  The plastic motherboard connector cover was too close, so I removed that.  I bought a good quality PCI-E splitter and connected that to the 4080 power cable.  The card won't work with the Alienware support brackets either. The main issue with the R13 as everyone is familiar is cooling and noise.  I went from a 3090 to the 4080 and the 4080 runs cooler out of the box.  This will get it up and running, but especially since you have the I9, you may want to get things cooler.  To get my PC as a whole where I was happy, I replaced all the fans, went push/pull on the CPU cooler and have both the 12700K and the GPU undervolted and overclocked.  This gave me better numbers, ran much cooler and is MUCH quieter.  Almost silent at idle and still very quiet regardless of playing games from Metro, Cyberpunk, Plague Tale which made it roar before.  I'm sure people who hate Alienware would say "but can you run two stress test simultaneously while the PC is in an oven at 450 degrees?"  Whatever, real world usage, it is great.  The R13 has been wonderful, but I have wanted a 4090 and considered the water cooled Suprim in the R13, but the sale Dell just had pushed me to get the R15 with 13900KF and 4090.  This machine will now go to my son who can finally stop complaining about lagging in Tarkov.  Maybe. [IMAGE]
I am wondering if I can upgrade my graphic card to the 40 version like the 4080
Aurora R13, graphic card upgrade 4080?