Seems to be a known issue with Publisher and other MS products.  Instead of double-clicking the .pub file, open Publisher and use File>Open to open the file. Ron
Vista 64 Ultimate with a.o. MS Office2007  student/home.  After installing a trial version Publisher 2007 and activating, I can open and work with the program by clicking the icon on the desktop.  But when I click a  .pub  file in a random map or save and try to open a file I get an error: not a valid win-32 application. I have tried to connect the .pub extension to the relevant files but after clicking I keep getting the same error. Also de-installed en installed Publisher  again but it didn’t work….what can I do to solve this problem? I don't have any problems with word, excel or power point. It is only publisher?
error: this is not a valid win-32 application