It may work but 80 GB is not a compatible configuration as per the specs here. 64 GB is compatible as is 128GB. 
Hello all. Been lurking and I am glad to have found this very helpful community. I just bought an R10 machine, yet to be delivered, for quite a fair price given the GPU market especially, $1450 US for Ryzen 7 5800, RTX 3060 ti, 512 GB mvme drive, killer wifi and liquid cooling. I have settled for 2* GB RAM, 3200 Mhz. This should fit my needs for starts but not long term. People like you are making me more knowledgeable by the day but what is possible when upgrading RAM is still hazy for me. My plan is simple yet with a twist: guessing that my computer will have one 8 GB stick into  slot 2 and another 8GB into  slot  4, (counting from the left) I would like to two 32GB sticks of the same Hyper X Fury brand, same speed, to reach 80 GB, this for editing video and large 3D scenes in Blender. So here are my questions: should I use plots 1 and 3 for the 32 GB sticks? will I run into efficiency problems? will I run into unforeseen problems? will my house catch fire? TIA for your time and patience.  JM
Aurora R10, upgrade RAM to 80GB?