I think your only choice is to run two video cables from the RTX 3080.
I have a U2723QE and a U4021QW running outside a server room. The connected PC is on the other side of the wall. I'd like to have both monitors connected to the PC without running another cable, but I'm about out of ideas. The U4021QW requires DP 1.4 for full resolution at 60Hz. It doesn't have DP output so it can't be the source of the DP MST daisy chain. The U2723QE has DP output, but I'm unsure if that connects on DP 1.4 which the U4021QW requires. Can anyone see options for daisy chaining these two displays? Thanks!
U2723QE, daisy chaining to U4021QW?