It's really going to come down to the load you put on the system. If you're storing lots of smaller files, a smaller stripe size may be beneficial. However, I'm not convinced that you'd notice much of a difference. I would somewhat expect the differences to be somewhat minor. I generally recommend to use the default settings. The presence of cache on the controller that accelerates reads and writes I would expect to mask most of the differences. You might see more of a benefit if you were trying to tune for a system with high-performance needs, but in this situation, I would think the defaults would work out well. 
Running ESXI 5.5 u3 on a single Dell PE T430 with a Perc H730.  My current RAID volumes are all SSD with 64k stripe sizes and RAID10.  I’m adding a new ESXI volume using 4 x 2Tb SATA in RAID10 and this will mainly be a storage volume for an existing Windows Server 2016 with Word, Excel and PDFs.  What would the best stripe size to use for this new RAID volume when I setup in my iDRAC?  I understand that smaller files benefit more with smaller stripe sizes like 64k. Thanks for any input. Ken
Best Stripe Size with ESXI