I had turned oplocks off on this share and made no difference.  I opened a case with Support and supplied them with PCAP log from a session with that client.  I was instructed to turn oplocks back on and run the test again.  The performance was what I would consider "much much faster".  That PCAP log was uploaded and am still waiting for feedback.  I'm also looking for another user to see if the problem persists with all users who acces this file or some.
Yeah, sounded cave man like..  Had a user complain about their files being "slow" after their data was migrated to the Isilon.  I visted the users and watched them open the file.    User 1 - MS Excel, performance was about what I expected - acceptable.to me, but may warrant some additional research.  HOWEVER,  User 2 - MS ACCESS performance was as follows.   Configuration is a 7 node X400 cluster.  6 of the nodes have both 10GB connections in use.  7th node is a storage node only.  Before I open a performance case are there any known issues with MS Access or other Office products that may have issues with Isilon?  Thanks,
Poor performance with MS Access on Isilon - Celerra good