That's a 165W CPU -- the answer is almost certainly no -- even if the system can boot with it, it'll throttle to the point where it'll probably be slower than a standard i9 CPU overall.  
Hi all, I'm considering upgrading the processor on my Alienware Area-51m R2 and I was strongly considering getting the Intel Core i9-10980XE. Does anyone know if this processor is compatible with the Area-51m R2? Thanks in advance!
Area-51m R2, can I use Intel Core i9-10980XE?