Dell oem ssd options for 7450. so yes both nvme and sata ssd work
I picked up this Opti 7450 AIO for a friend who desperately "needs" a new PC (ain't goin' there as to what he uses now..!) and this was really inexpensive from my local "rebuilder".  But it came with a 7th Gen i5 and a 1TB SATA disk, which is OK, but having spoiled myself with SSD operational speed, I intended to replace this with a 512 GB SATA SSD... And was surprised to open this up and see an M.2 slot on the M/B (?)  Rilly? ... Well my poor little brain went into overdrive, seeing this, so I immediately slid over here to ask: I see that the Intel Optane 64GB is mentioned in the specs, but is this the only compatible M.2 drive that has been "tested and approved" or can I consider something like the Samsung 860 NVME I have in my 'stores drawer', or is it limited to SATA? Or CAN it accommodate any NVME of any form? ... or what precisely...? What are my options with this dude?  Is it bootable or suitable only for additional storage or what, exactly..?  I seem to have accumulated more than a couple of both SSDs and M.2's over the past few weeks (for  what reason I cannot explain - Um, maybe mostly 'cuz I love toys?) so I have  more than a couple of potential options, but with the cost of just about any solid sate disk being as low as I've seen, recently, (like $47...?) this just "tickles my fancy" as it were...  Input and advice from "out there.." please..?
Optiplex 7450 AIO M.2 slot drive compatibility