The answer is: Yes. You can safely uninstall the Spanish and French versions of Microsoft (Office) 365, if you wish, without harming the English version.
My version of Windows 11 Pro includes English, French and Spanish. As a result, I have three versions of Microsoft (Office) 365, as shown in the image below, which was taken from Settings > Apps > Installed apps:  Can I uninstall the French and Spanish versions that I will never use, without harming the English version? Or do I have to uninstall everything, and download Microsoft (Office) 365 again? (I have a current subscription to Microsoft 365 Family.)
Can I Uninstall Unused French and Spanish Versions of Microsoft 365?