Hi [NAME] there continues to be speculation that Microsoft are introducing changes (evolving) and these changes make it hard for the Dell SupportAssist application to function. On 23 May 2022 the windows transition to using Microsoft .Net Runtime - 6.0.5 (x64) caught my attention and I manually updated.  Still not sure why SupportAssist v3.12.1.180 installation was having problems and struggling to work. Not sure how this version has became stable.  This thread has an unknown solution. 
SupportAssist update installation invalid. See images that dispute SupportAssist version and declares that installation location is invalid. Dell SupportAssist application has been repeatedly removed and reinstalled to reinstate its full function, and Alienware 17 R5's Diagnostics, and Drivers & Downloads. But now always defaults to installation at "C:\Program Files\Dell\SupportAssistAgent\Bin\SupportAssistUI.exe", and struggles to work.  Dell messed-up again, is there a fix for this SupportAssist update?  [IMAGE]Dell SupportAssist Version 3.12.1.180[IMAGE]Dell SupportAssist Version 3.12.5.0[IMAGE]SupportAssist Shortcut[IMAGE]SupportAssist installation invalid
17 R5, SupportAssist x64 v3.12.5.0 or v3.12.1.180 installation invalid