if you are removing extra paths to a device and there is some sort of multi-pathing on the host, you will not experience any issues. You might have to do some clean up in PowerPath to delete dead paths.
Hello,  We hit a max number of SCSI paths to a ESXi host 1024 as we are having 8 paths per each lun, in order to go pass this issue we decided to reduce the number of paths to 6. So we need to remove one zone member from each fabric.  We are having two Connectrix ED140M(Mc data) switches first one represents Fabric A and the other Fabric B. So does this cause any disruption to the production or any data loss if we do this activity on the fly and I'll be doing this on one fabric at a time.  we've powerpath/ve 5.7 for all the hosts.
Need to remove the zone members from active zones does this require downtime 
for the host