for those who may have read this, i received a response from support. This connectivity APD setting is specific for ESX hosts and does not affect your RPA's. Please note, that you do want to set this to APD as APD expects for the paths to return after the storage controller reboots during the upgrade and PDL does not, as it is "Permanents Device Loss".  Thanks.
per the most recent XIO Upgrade Customer Preparation guide, there is a requirement to change the array connectivity mode from PDL (previous default setting) to APD if you have VMware ESX servers attached. See KB 483391. I am OK doing that but the KB doesn't provide information regarding impact to other non-ESX initiators such as RecoverPoint.  Is it safe to assume there will be no impact to non-ESX hosts with the connectivity parameter change? It's a cluster-wide change thus my concerns.  PS: I do have a SR opened to answer this question but I haven't received a response yet (2 days) and i have a scheduled activity this Sunday to change one site array.  thanks.
XtremIO Connectivity parameter change