It's not possible without using virtualization, no.  If you must run a DOS version, you need a system old enough that it still has support for CSM/Legacy mode -- a UEFI only system will not do the job.  
Hi,   Is it possible to run or natively install MSDOS on this machine?  I'm not talking about DOSbox or any Virtual machines.  I want to boot up natively in DOS either from the internal drive, or an external USB HDD or Floppy or CD?  I think the BIOS says it doesn't support LEGACY, so am I out of luck?   Thanks...
Installing or Running DOS on Inspiron 7706