Hi, A single RPVM cluster can manage 5 vCenters and a single vCenter can have up to 50 RPVM clusters. Note that the vRPAs would need to communicate over TCP/IP with all ESXs in a cluster with protected VM.   Hope that helps, Idan    
Hello, My customer have 2 different VxRail clusters in 1 datacenter, with 1 vCenter server managing both VxRail clusters. We need to configure RP4VM for local protection. Is 1 vRPA cluster for each VxRail cluster and only 1 vCenter server supported? Is 1 vRPA cluster for both VxRail clusters and only 1 vCenter server supported? Are there any limitation to the number of vRPA clusters that can be deployed with only 1 vCenter server managing 2 or more VxRail clusters? Appreciate any advise. Thanks. Rgds,Kay Shin
RP4VM with VxRail