I know you did not mention Jumbo Frames but this article does a good job discussing the ins and outs of enabling larger frames in your network.  The answer is really subjective to your particular network and what traffic you are running thru it. www.smallnetbuilder.com/.../30201-need-to-know-jumbo-frames-in-small-networks I hope this helps,
Just curious if there is any performance gain by increasing the frame size of ports in a LAG connecting two switches (both are 6248P)? If so, what size would be optimum?
6248P LAG MAX FRAME SIZE Question