The answer is yes, though you'll need more than just the mainboard -- you'll need a new heastsink assembly and if you currently have a 65W power adapter, a 90W or better one.  All told, you're looking at well $300 or more just in parts.  Carefully compare the cost of a parts-only approach to that of buying a new(er) system -- putting that much money into an 8-year old system does not make much economic sense. One source of boards: [URL]  
Hi So ive have this Lattitude e5550 since 2015 and I passed it down to my brother. He ever since he has it hes been playing games on it like Fortnite, Gta V and roblox etc etc. But he is having concerns of if he can change the mother board from the normal Intel HD to the nVidia Mother board I myself couldn't confirm if he could or not but I thought of buying the motherboard but wasn't sure if it will work with it or if i'd need to buy something else for it to work.
E5550 - will a nvidia motherboard work