Jeff it looks like what you are descirbing is a distributed boot volume. Today this is not supported and you should see that restriction on the ESSM soon. You could replicate the boot volume using VMAX replication tools to the second site. If you want to create a local boot volume presented through the VPLEX that is fine.
Using Vplex metro, we have a number of physical servers starting to request boot from SAN so OS drive is available at DR site.  Anyone doing this successfully with VPLEX fronted Storage?   We have VMAX backend.  Jeff
Vplex Metro- anyone booting from SAN?