If it supports one, it will support two. However, it does not fit within the specifications that Dell has published for supported 5000-series processor specs: Up to two Dual-Core Intel Xeon 5000 sequence processors at up to 3.0GHz (runs at 3.73GHz)Intel Xeon 5000 Sequence: Dual Independent 667MHz (has 1066MHz)Intel Xeon 5000 Sequence: 2x2MB (OK - has 4MB) All the above may or may not  make a difference, but to add to that, the 5080 is also a 130W processor, requiring more power than any of the processors that meet the published specs (the X5355 is 120W).  The BIOS updates talk a lot about support being added for newer processors, but those are specifically named as being from the 5100/5200/5300/[5400] family, not the 5000 ... and nothing specifically about support for faster speeds/versions.  Now, that doesn't mean it won't work, just that there is a good chance that it will not.  So, if you have a 5080 to try, are getting one at a price that makes failure an acceptable risk, or have a good return policy, then try it and post what happens.  If not, then I would go to something that is definitely supported and even better than a 5080 (like a X5355).
Hello, all. I have a PowerEdge 1900 server (with II on the chassis) that originally had a Xeon 5050 3.00 GHz CPU.   Does this server support a Xeon 5080 3.73 GHz CPU?  If so, it would support two of these, correct?   Thanks!
PowerEdge 1900 II CPU upgrade