No issue and EMC provides support for all vSphere components.
I am aware that VxRail includes 15 VM licenses of RecoverPoint for VMs.  If the customer would rather use vSphere Replication (VR), for example to protect 100 VMs (to avoid purchasing additional RP4VM licenses), is that scenario fully supported?  In other words, the customer is opting to use VR instead of RP4VMs.  If they call EMC Support and ask for assistance with vSphere Replication (VR) issues, will EMC Support will fully support the customer?
Any issues using vSphere Replication with VxRail?