Did you give permission in Windows? With speakers and mic plugged in, go to these screens: [IMAGE] Is volume for the mic turned up? (See bottom of Sound screen, below) Is Sound output set up correctly in Windows? [IMAGE] And choose the input device on the Sound screen too. Keep in mind this PC uses Waves MaxxAudio Pro as its main Sound controller. So you have to open Waves and configure it on its Playback screen to use your speakers. But first, power PC off and disconnect speakers (or earbuds) and mic. Boot PC and make sure Waves gets launched at boot. Then plug speakers into the correct port on PC and wait until Waves pops up and asks what you connected. Select the best option on the popup's list. Then open the Waves control panel and configure the speakers (turn the Equalizer on, choose music type, etc) on the Playback screen.  Close the control panel when done with speakers. Next, plug the mic into PC and wait to see if Waves pops up ask about that and choose the right option. Then open Waves and click the Voice screen and be sure to turn the mic on there too, and run the test at bottom of that screen to set mic volume. BTW: the audio input (mic) port on this PC is listed as a headset (headphone and microphone combo) port. So it may not work if you only have a mic without earbuds built in, and/or you may need an adapter for the mic's plug to work with this PC, even though the plug fits into the port on PC.  
I have a Dell 3881, windows 11. Whatever connection I use, at the moment only the camera appears to be working. I cannot get other two to run.   All worked OK on my last 3650 which had many more connections.
Connection camera, mic and speaker.