Thank you Charles for your reply! Yes, we had already tried the other working blade in this slot and didn't work, so we were sure that this was a Brocade and not a blade issue. Also our Brocades are not configured in Access Gateway mode but in Native mode. After all basic and advanced troubleshooting has been done on the Brocades we decided to do a rolling restart on the 2 FC switches.  After the reboot the first Brocade immediately detected the new M630 on (licensed) port 11 as 'N16 Online FC F-Port '.  The second Brocade did not immediately detect the blade but after a 'portcfgpersistentenable 11', which now worked without error, it detected the new blade too! The rolling reboot did not affect the production traffic at all, as the system (XenServer) had multipath enabled with active-active configuration.So, case is closed.
Hi Everyone, We have a M1000e chassis with 2 Brocade M6505 FC IOMs (B1/B2) and 9 working blades (M620/M630). The Brocades have 12 port licenses from which 1 is available. Brocades have DPOD mode enabled. The switchshow command shows active ports as 'N16 Online FC F-Port ' and the unused but licensed port 'In_Sync FC Disabled (Persistent)'. When we insert a new M630 blade with a dual port FC Qlogic QME2662 mezzanine HBA in slot B (fabric B), status of port 11 does not change and there is no connection indication on the Brocade, and the blade iDRAC shows the port 'down' and 'No Link'.  Note that the M630 has already OS installed (XenServer). We issue the "portcfgpersistentenable 11" command but we get: "Port 11: portcfgpersistentenable failed. Configuration operation is not supported on internal (server blade) port." The same blade was inserted to a slot of another already working blade and the switch detected it normally, showing the WWPN and the port going 'online' both on Brocade and in iDRAC. That eliminates any blade misconfiguration possibility. In this port portcfgpersistentdisable and portcfgpersistentenable commands are working normally. Note that when this slot is empty it shows as 'No_SigDet' and not as 'Disabled (Persistent)'. We included port 11 in the zoning configuration (forcibly aliasing the blade's WWPN) but no change in port status.  Are we missing something here? Does anyone have an idea on how to proceed?
Brocade M6505 (in Dell M1000e) licensed blade port cannot be (persistent) 
enabled