Xeon 5500 and 5600 series processors are supported, including the X5650 specifically: [URL] You will need to update the BIOS (and other system firmware) before installing new processors.
I am looking to upgrade my PE T410 CPU's.  Looking at the manual it states it can be upgraded to Xeon X5560 or E5000 Series Processor.  I was wondering if it can support the X5650?  Would love the 6 core proc.  
PE T410 CPU Upgrade