This is the closest thing I could find to a guide. [URL] We'll be using it, but we also had to turn off oplocks for those shares where IIS is accessing Isilon over SMB.
I'm currently taking an EMC class for Isilon Admin and during the course of instruction it was mentioned there is a way to enhance performance of Windows IIS servers accessing SMB shares on the Isilon.  I've been searching for a EMC document (White Letter) that explains the process but I can't find it and was hoping someone could point me to it.  The training material states:  [IMAGE] Microsoft Internet Information Services (IIS) server can use its virtual directory feature to store website content remotely from the IIS web server. That content can experience poor performance when located on an Isilon cluster because IIS establishes only a single connection to the cluster. This problem can be resolved by establishing connections to multiple nodes within the cluster, and even establishing multiple connections to individual nodes. IISConnectIQ is a flexible load balancer that offers three different load-balancing policies: round-robin, random, and hashed. The objective of using the load-balancer is to convert UNC path names of the form \\clustername\...to UNC paths of the form \\node\.... This translation is performed transparently, ensuring that IIS-hosted applications do not need to be modified. As each UNC path is translated, IIS determines whether a connection to the node already exists and, if a connection does not exist, establishes a new one. Depending on the IIS server configuration, load, and load- balancing policy, IIS can send requests to any or all nodes, and even multiple connections to each node. This arrangement exploits the OneFS cluster architecture and maximizes the performance of IIS-hosted applications.
IIS ConnectIQ White Letter