A few days ago, a computer technician came to my house to help. He did several diagnostics test, including one with Linux. He concluded that reinstalling Windows 10 was not a solution. At one point he said that he noticed static electricity. He opened the computer, changed the cell battery, reassigned external USB and HDMI devices to different USB ports. Three of the UBS ports in the rear were left empty. He said that there was a mixed up of USB 2.0 and USB 3.0. The mouse USB cable went back to the rear port. So far so good. Device manager still shows several unknowns and one with an exclamation sign. I accept this as solution to the mouse problem. Thanks to everyone. [IMAGE]  
I have been dealing with this mouse issue for two weeks. My original Dell wired mouse that came with my Dell XPS 8910 computer is not working. I have Windows 10 21H1, up to date. The light on the mouse is on, but the cursor is absent. When I plug it in any USB port, a message pops “Windows Explorer. USB device not recognized. The last USB device you connected malfunctioned, and Windows does not recognize it”, and I read “Windows has stopped this device because it has reported problems (code 43). A request for the USB device descriptor failed”. I have tried different USB ports, and I have tried with two different mouses. The USB ports seem OK because they work with other devices. The mouses are OK, because they work with two other different computers. The Device Manager shows two, sometimes three “Unknown USB Device (Device Descriptor Request Failed)” USB controllers. Uninstall of these does not fix the issue. A System Restore to August 2 2021 fixed the mouse for a few hours. When I tried another USB port for the mouse, the problem returned, so, I went back to the first USB port (where the mouse was plugged in during restore). Unfortunately, the issue came back a few hours later.  I have visited the “Mouse Usage and Troubleshooting Guide” several times. I have tried all the suggestions. The Dell SupportAssist app doesn’t find mouse issues. I have tried all suggestions for the “code 43” issue, without luck.  Any new suggestions are welcomed.
XPS 8910, USB, mouse issue