Globally setting MTU to 9216 should have no impact, or little impact, to devices still sending 1518 packets. During TCP handshake the MSS (Maximum Segment Size) will be set between two devices. This means that if device A is utilizing jumbo frames, reaches out to communicate with device B that does not support jumbo frames. Device B will return a MSS of 1518, and Device A will then change the frame size to match the MSS.  If you enable jumbo frames on one switch, it is recommended that all switches have jumbo frames enabled. Once Jumbo frames is enabled, I suggest initially monitoring network performance for any adverse reactions.
Hello All, I am in process of configuring N4064F switch that will act as Xenservers hyper-visors  backbone  We intend to connect 2x10G LACP for each server, 8 of them to use nfs storage  mount connection , each of the nfs we would like to make it mtu jumbo frame , and the rest of 10G connection with normal mtu 1518 I can see on manual that jumbo frame activation  is only global settings and not individual per port "#system jumbo mtu 9216" , and next all ports shows with MTU 9216 My question is would setting will cuase normal port with host operate mtu 1518 issues or i can safly turn this option on ? Please advice  Thanks 
Settings Jumbo frame on N4064F with mixed port settings