There is no known issue like this.  My recommendation would be to reboot SIS, and in the event of repeated failure to re-deploy the OVA, perhaps using a different IP.  You can of course choose to open an SR instead and support will guide you through collecting logs.
We have installed emc_solutions_integration_service_v69_x86_64_OVF10.ova recently and getting below error while trying to launch the web UI.  Please suggest how to fix this issue  [IMAGE]
EMC Solutions Integration Service HTTP Status 404