Nope.  Only key that will be asked is for the operating sytstem that you are going to.  The upgrade will check current registry of current installed operating system. 
  I had a DEll 4100 the case is long gone and I didn't write the OEM Win2000 pro Software key or the service tag info down -I purchased a XP pro upgrade package from amazon, The question I have is Doing the upgrade will I need the winpro product key to complete the install or will the xp-pro upgrade package allow me to do a clean install on a New HD?   I looked on the dell my account page and it list all my dell computers going back to the dell 4200 I still use- I can not find any info for my old dell 4100. I contacted MS since the software I have was purchased from Dell the handed me off to dell very fast.   Thanks for ant and all input.
Software KEY