I'm pretty sure this is the problem you are having,  found it on the Equallogic Website KB. Solution Title MTU 1.1 on Windows 2008 SP2 errors with IO error on volume ( OSError: permission denied)  Solution Details When using MTU - Manual Transfer Utility 1.1 with Windows 2008 SP2  The software keeps error with "I/O error on volume (OSError: [Errno 13] Permission denied)  under diags you see c\:\\Program\ Files\\Equallogic\\reptool/reptool.exe is hanging up trying to online the volume.  This appears to be an issue with the new security restrictions in Windows 2008 SP2. The tool errors out and is no longer able to online the volume for replication thus error out with permission denied. Also logging in as default administrator and/or with run as administrator has no effect on this message and getting around it.  Please go to Disk Management and online the volume manually. Then proceed with the MTU process. If this fails with subsequent errors, please recommend using another operating system such as Windows XP SP2 if available to the customer. 
Trying to load data with MTU GUI, getting following error: "Data transfer operation could bnot start due to the follwing error: I/O error on volume: OSError; [Errno 13] Permission denied"   What am I missing? Anyone seen this error before using reptool? Thanks K  
Equallogic MTU offline repl - data load - errorno 13