Specs say it can use a 6th Gen i3, i5, or i7. I'd make sure the latest version of BIOS is installed and working with the i3 before swapping in the new CPU. Have a tube of decent thermal paste handy, and gently clean the old paste off the bottom of the heat sink.
Will the swap out with a i3 6100 CPU 3.7 GHz HD graphics 530 on a OC2XD version A01 motherboard 
intel core i5 6500 core 15 6th gen Skylake Quad core 3.2 GHz LGA 1151 65w intel 
HD graphics 530