I was referring to the specific cable and port associated with that NIC.  It could also be a bad NIC. 
Have 1 virtual server (in hyper-v) with 4 nics. Server OS Win2008R2 Sp1 with EQL ASM is version 4.5. The lan nic is excluded by subnet in auto-snapshot manager/MPIO Settings. The 3 SAN adapters are in another subnet and are "included". The 3rd nic has no active sessions to the storage array. ISCSI connections MPIO tab confirms its allowed to connect to the san. Instead of 3 connections to the volume over 3 nics it's making 2 connections over 1 etc... Tried ping from the EQL to the configured IP of this particular nic, got no replies. The other 2 IP's are pingable. Checked the Hyper-V host; The 3 nics are in the same Vlan. This virtual server is the only one connected to the san with this issue. Any ideas on why and how to solve this?  
Dell Eql MPOI not using all configured nics