I'm not EMC support but I would try this video for a good walkthrough of the process:  [URL]  As for port assignment: as I understand it the replication traffic will exit the SP on the ports which the device can reach the remote system on. Those ports can be any ports within the device depending on the network configuration of the port. And like the previous poster mentioned you can aggregate ports if you choose.
I have tho VNXe 3100 storage systems, one for production and one for DR.  I have installed Replication Manager server on a host, and the production host connected via iSCSI to the production VNXe.  The production host has PowerPath, Unisphere server agent and Replication manager host installed.  I have read several documents about Replication Manager but I have not found how to configure the ports that each VNXe will use for replication purposes.  Which VNXe ethernet ports should I configure for replication? I have a total of six ethernet ports on each SP, two of them on each SP are being used for iSCSI conectivity.
How can I configure my two VNXe systems to replicate?