the nipam polymers utilized in the present invention have the following formula : wherein n is a whole number of from 10 to 3 , 000 . the nipam polymers utilized in the present invention include various types of polymers that comprise the above - described monomer . the polymers may be formed entirely from the nipam monomer identified above , or other monomers can be incorporated into the polymer by copolymerizing the nipam monomer with other monomers , such as acrylic acid , acrylamide , n - acetylacylamide , n , n - dimethylacrylamide and butyl methacrylate . in addition , modified polymers or copolymers containing the nipam monomer can be prepared by functionalization of end groups , preparation of block copolymers , and cross - linking of polymers . all such polymers , copolymers or modifications thereof are referred to herein as either “ nipam polymers ” or “ pnipam ”. the nipam polymers utilized in the present invention will typically have molecular weights of from 1 , 000 to 300 , 000 daltons . the polymers are available from polymer source , inc ., dorval , quebec ( canada ). the amount of pnipam utilized in the compositions of the present invention will vary depending on the form of the compositions and the intended use thereof . the concentration of pnipam utilized will generally be an amount sufficient to obtain a solution surface tension of less than 50 millinewtons per meter (“ mnm − 1 ”) at room temperature ( 23 ° c .). the above - described nipam polymers are surface active , and therefore will readily adsorb to most types of surfaces . factors such as the type of surface ( hydrophobic versus hydrophilic ), temperature , buffer and excipients will influence the interaction between the polymers and a surface , and will influence the magnitude of the interactions . the above - described pnipam polymers may be combined with other components commonly utilized in products for treating contact lenses , such as rheology modifiers , enzymes , antimicrobial agents , surfactants , chelating agents or combinations thereof . the preferred surfactants include anionic surfactants , such as rlm 100 , and nonionic surfactants , such as the poloxamines available under the name “ tetronic ®”, and the poloxamers available under the name “ pluronic ®”. furthermore , a variety of buffering agents may be added , such as sodium borate , boric acid , sodium citrate , citric acid , sodium bicarbonate , phosphate buffers and combinations thereof . the compositions of the present invention that are intended for use as clc products will contain one or more ophthalmically acceptable antimicrobial agents in an amount effective to prevent microbial contamination of the compositions ( referred to herein as “ an amount effective to preserve ”), or in an amount effective to disinfect contact lenses by substantially reducing the number of viable microorganisms present on the lenses ( referred to herein as “ an amount effective to disinfect ”). the levels of antimicrobial activity required to preserve ophthalmic compositions from microbial contamination or to disinfect contact lenses are well known to those skilled in the art , based both on personal experience and official , published standards , such as those set forth in the united states pharmacopoeia (“ usp ”) and similar publications in other countries . the invention is not limited relative to the types of antimicrobial agents that may be utilized . examples of antimicrobial agents that may be used include : chlorhexidine , polyhexamethylene biguanide polymers (“ phmb ”), polyquaternium - 1 , and the amino biguanides described in co - pending u . s . patent application ser . no . 09 / 581 , 952 and corresponding international ( pct ) publication no . wo 99 / 32158 , the entire contents of which are hereby incorporated in the present specification by reference . the preferred antimicrobial agents are polyquaternium - 1 , and amino biguanides of the type described in u . s . patent application ser . no . 09 / 581 , 952 and corresponding international ( pct ) publication no . wo 99 / 32158 . the most preferred amino biguanide is identified in u . s . patent application ser . no . 09 / 581 , 952 as “ compound number 1 ”. this compound has the following structure : it is referred to below by means of the code number “ al - 8496 ”. the ophthalmic compositions of the present invention will generally be formulated as sterile aqueous solutions . the compositions must be formulated so as to be compatible with ophthalmic tissues and contact lens materials . the compositions will generally have an osmolality of from about 200 to about 400 milliosmoles / kilogram water (“ mosm / kg ”) and a physiologically compatible ph . the compositions of the present invention and the ability of those compositions to reduce protein adsorption on contact lenses are further illustrated by the following examples . unmodified ( i . e ., non - ionic ) nipam polymers and modified ( i . e ., end terminated with — cooh groups ) nipam polymers were added to appropriately buffered solutions to demonstrate the ability of these polymers to reduce protein adsorption when utilized as components of buffered multi - purpose solutions for treating contact lenses . a simple means of producing pnipam - modified surfaces was used in order to mimic the contact lens disinfection / cleaning regime typically used by the consumer . the tests described below were conducted to evaluate the ability of nipam polymers to modify contact lens surfaces and thereby reduce protein adsorption . the materials and methods utilized in the evaluation were as follows : lysozyme ( sigma , chicken egg white , grade 1 , 3 × crystalline ), trifluoroacetic acid anhydrous ( sigma , protein sequencing grade ) acetonitrile ( em science , hplc grade ), sodium phosphate monobasic , monohydrate ( sigma , acs reagent grade ), sodium phosphate dibasic , anhydrous ( sigma , acs reagent grade ), sodium chloride ( sigma , ultra pure grade ), unisol ® 4 ( alcon laboratories , inc ., preservative - free . ph - balanced saline solution for rinsing ) the nipam polymers utilized are identified in table 1 below . these polymers were purchased from polymer source inc . and were used without further purification . acuvue ( vistakon , a division of johnson & amp ; johnson vision products , inc ) lenses were used as the substrate in this study . the lenses had the following parameters : 42 % etafilcon a , 58 % water , fda group iv lens . diameter , 14 . 0 mm ; base curve , 8 . 8 mm ; power , − 2 . 00 . the nipam and nipam - cooh polymers identified in table 1 were formulated at ph 7 . 8 in a buffered vehicle containing 1 . 5 % sorbitol , 0 . 6 % boric acid and 0 . 32 % nacl . in a beaker , all the formulation chemicals except for the nipam polymers were weighed out and purified water was added ( qs to 95 %). the ph was adjusted to 7 . 8 with naoh / hcl . the nipam polymer was weighed out and added to the buffer solution and this was stirred overnight to solubilize the polymer . the test formulations are shown in table 2 below ; the concentrations are expressed as weight / volume percent (“ w / v %”): phosphate buffered saline ( pbs ) 1 . 311 g of monobasic sodium phosphate ( monohydrate ), 5 . 74 g of dibasic sodium phosphate ( anhydrous ), and 9 . 0 g of sodium chloride were dissolved in deionized water and the volume was brought to 1000 ml with deionized water , and ph was adjusted ( as necessary ). the final concentrations of sodium phosphate and sodium chloride were 0 . 05 m and 0 . 9 %, respectively . the final ph was 7 . 4 . a 1 . 5 - mg / ml lysozyme solution was prepared by dissolving 750 mg of lysozyme in 500 - ml phosphate buffered saline ph adjusted to 7 . 4 . a lens extraction solution was prepared by mixing 1 . 0 ml of trifluoroacetic acid with 500 - ml acetonitrile and 500 ml of deionized water . the ph of the solution ranged from 1 . 5 to 2 . 0 . each lens was immersed in 3 - ml of each test formulation and allowed to sit at room temperature overnight . the next morning , the lenses were removed from the test formulations and dabbed lightly on a towel . each presoaked lens was immersed in a wheaton glass sample vial containing 3 - ml of lysozyme solution . the vial was closed with a plastic snap cap and incubated in a constant temperature water bath at 37 ° c . for 24 hours . three additional lenses were included as controls to establish the total amount of lysozyme deposited . after incubation , the deposited lenses were removed from their vials and rinsed by dipping into three consecutive beakers containing 200 ml unisol ® 4 or water to remove any excess of the deposition solution . the lenses were extracted with 5 ml of acn / tfa extraction solution in a screw - capped glass scintillation vial . the extraction was done by shaking the vial with a rotary shaker ( red rotor ) at room temperature for at least 2 hours ( usually overnight ). quantitative determination of the lysozyme of the lens extract was carried out using a fluorescence spectrophotometer interfaced with an autosampler and a computer . the fluorescence intensity of a 2 ml aliquot from each sample solution was measured by setting the excitation / emission wavelength at 280 nm / 346 nm with excitation / emission slits of 2 . 5 nm / 10 nm , respectively , and the sensitivity of the photomultiplier was set at 950 volts . a lysozyme standard curve was established by diluting the lysozyme stock solution to concentrations ranging from 0 to 40 μg / ml , using the acn / tfa extraction solution for the lens extract and the vehicle for the soaking solutions . the instrument settings for measuring the fluorescence intensity were the same for the lens extracts and lens soaking solutions . the lysozyme concentrations for all of the samples were calculated based on the slope developed from the linear lysozyme standard curve . the % prophylaxis of each formulation was calculated by subtracting the amount of lysozyme in the lens extract from the amount of lysozyme from the control lenses ( total deposit ), then dividing that by the total deposit and multiplying by 100 . fig1 shows the % prophylaxis as a function of pnipam concentration ( g / 100 ml ) for nonionic nipam polymers having molecular weights of 46 , 380 ; 71 , 600 ; and 122 , 000 , respectively . fig1 shows that there was no significant pnipam molecular weight dependence on the % prophylaxis using the defined polymer concentrations . pnipam concentrations up to 0 . 2 g / 100 ml gave % prophylaxis results of approximately 30 %. with increasing pnipam concentrations above 0 . 2 g / 100 ml the % prophylaxis could be increased to 50 % to 60 % using polymer concentrations between 0 . 4 g / 100 ml and 0 . 65 g / 100 ml . the % prophylaxis was not dependent on the molecular weight of the nipam polymers . the prophylactic properties of nipam polymers were further evaluated using a 3 - day cycling study . two sets of lenses were prepared . one set was presoaked in the formulations shown in table 2 before going into the lysozyme solution , whereas the other set was not . both sets of lenses were then placed in the lysozyme solution for 8 hours ( day 1 ). at the end of the day all the lenses were rinsed and put in their respective formulations to soak overnight . the following day ( day 2 ), the lenses went back into the lysozyme for the day ( 8 hours ). this was repeated to complete 3 cycles ( 3 days ). at the end of the experiment all the lenses were analyzed in accordance with the procedures described in example 1 . the results are presented in table 3 : the results demonstrate that the buffered solutions containing a nipam polymer ( i . e ., p2991 - nipam ) were effective in reducing protein uptake in both the presoaked and non - presoaked lenses . for example , the presoaked lenses treated with solutions containing concentrations of 0 . 034 % and 0 . 017 % of the nipam polymer demonstrated prophylaxis values of 67 . 8 % and 60 . 8 %, respectively . for the non - presoaked lenses the prophylaxis values were 45 . 9 % and 41 . 9 % at concentrations of 0 . 034 % and 0 . 017 %, respectively . the results set forth in table 3 demonstrate that treatment of the lenses with a nipam polymer solution prior to exposure to proteins is preferable . however , the results also show that even when the lenses have already been exposed to proteins prior to an initial treatment with a nipam polymer solution , the uptake of protein is reduced when the lenses are subsequently treated with a nipam polymer solution . thus , the results of this study confirm that the compositions of the present invention are effective in reducing the formation of protein deposits on contact lenses , even when the lenses are repeatedly exposed to protein contamination . the prophylaxis work was extended to formulations containing the antimicrobial agent al - 8496 with unmodified nipam ( non - ionic ) and modified nipam ( end functionalized with cooh ) polymers . the formulations evaluated are shown in table 4 , below : the procedures utilized were the same as in example 1 . fig2 shows the prophylaxis data obtained using the overnight soak model with lenses pre - soaked in the respective pnipam formulations . fig2 shows that the prophylaxis properties of the nipam polymers were retained in the presence of the antimicrobial agent al - 8496 and other formulation components , including cleaning ingredients ( e . g ., citrate and tetronic ® 1304 ). the data demonstrate that both unmodified and modified nipam polymers can be incorporated into multi - purpose contact lens care formulations without compromising the prophylactic properties of the polymers . the disinfection activity of the formulations shown in table 4 above was also evaluated . the results are shown in table 5 below . several formulations were evaluated to compare the prophylaxis properties of pnipam with two well - known block co - polymers , tetronic ® 1107 and pluronic ® f127 . the formulation components and prophylaxis results are given in table 6 , below . the evaluation was carried out using the same procedures as outlined in example 1 . the buffered solution utilized as a control ( 10581 - 85j ) did not exhibit any prophylaxis properties . however , as shown in table 6 , the compositions of the present invention containing pnipam at concentrations of 0 . 2 % ( 10581 - 85b ) and 0 . 4 % ( 10581 - 85c ) produced prophylaxis results of 56 . 2 % and 63 %, respectively . in contrast , the solutions containing tetronic ® 1107 and pluronic ® f127 block co - polymers at concentrations of up to 0 . 8 % did not produce any significant prophylaxis .