the novel compounds encompassed by the instant invention can be described by general formula 1 : ## str3 ## wherein : r 1 , r 2 , r 3 , r 4 and r 7 , r 8 and r 9 are the same or different and represent hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; where x carbon , r 6 represents hydrogen , halogen , hydroxy , lower alkyl having 1 - 6 carbon atoms , or lower alkoxy ; and where x is nitrogen , r 6 represents an electron pair , where y is carbon , r 10 represents hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; and where y is nitrogen , r 10 represents an electron pair ; where z is carbon , r 11 represents hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy , or phenyl optionally substituted with one or two groups selected from hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; and when z is nitrogen , r 11 represents an electron pair ; r 12 and r 13 taken together may represent ( cr x r y ) s where s is an integer of from 1 - 6 and r x and r y independently represent hydrogen or lower alkyl ; r 7 and r 8 together may represent a benzo ring optionally substituted with up to four substitutents selected from hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; and r 14 , r 15 , r 16 and r 17 are the same or different and represent hydrogen or lower alkyl . preferred compounds of formula 1a are those where s is an integer of from 1 - 4 , and most preferably from 2 - 3 . the present invention also encompasses compounds of formula 2 : ## str4 ## wherein : r 1 , r 2 , r 3 , r 4 and r 7 , r 8 and r 9 are the same or different and represent hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; where x carbon , r 6 represents hydrogen , halogen , hydroxy , lower alkyl having 1 - 6 carbon atoms , or lower alkoxy ; and where x is nitrogen , r 6 represents an electron pair ; where y is carbon , r 10 represents hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; and where y is nitrogen , r 10 represents an electron pair ; where z is carbon , r 11 represents hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy , or phenyl optionally substituted with one or two groups selected from hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; and when z is nitrogen , r 11 represents an electron pair ; r 12 and r 13 taken together represent ( ch 2 ) s where s is an integer of from 1 - 6 ; r 7 and r 8 together may represent a benzo ring optionally substituted with up to four substitutents selected from hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy . preferred compounds of formula 2 are those where s is an integer of from 1 - 4 , and most preferably from 2 - 3 . the present invention further encompasses compounds of formula 3 : ## str5 ## wherein : r 1 , r 2 , r 3 , r 4 and r 7 , r 8 and r 9 are the same or different and represent hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; where x carbon , r 6 represents hydrogen , halogen , hydroxy , lower alkyl having 1 - 6 carbon atoms , or lower alkoxy ; and where x is nitrogen , r 6 represents an electron pair ; where y is carbon , r 10 represents hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; and where y is nitrogen , r 10 represents an electron pair ; r 7 and r 8 together optionally represent a benzo ring optionally substituted with up to four substitutents selected from hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy . preferred compounds of formula 3 are those where m is 2 , 3 or 4 . particularly preferred compounds of formula 3 are those where m is 2 or 3 ; r 1 , r 2 , r 3 , r 4 are hydrogen ; r 7 and r 9 are hydrogen and r 8 is hydrogen , hydroxy , halogen or alkoxy . more particularly preferred compounds of formula 3 are those where m is 2 or 3 ; r 1 , r 2 , r 3 , r 4 are hydrogen ; r 16 is hydrogen or methyl ; r 7 and r 9 are hydrogen ; and r 8 is hydrogen , hydroxy or methoxy . still other preferred compounds of formula 3 are those where m is 2 or 3 ; x and y independently represent methylene optionally substituted with lower alkyl , preferably methyl ; r 1 , r 2 , r 3 , r 4 are hydrogen ; r 16 is hydrogen or methyl ; r 7 and r 9 are hydrogen and r 8 is hydrogen , hydroxy or methoxy . the present invention also encompasses compounds of formula 4 : ## str6 ## wherein : r 1 , r 2 , r 3 , r 4 and r 7 , r 8 and r 9 are the same or different and represent hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; where y is carbon , r 10 represents hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; and where y is nitrogen , r 10 represents an electron pair ; r 7 and r 8 together may represent a benzo ring optionally substituted with up to four substitutents selected from hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy . preferred compounds of formula 4 are those where m is 2 , 3 or 4 . particularly preferred compounds of formula 4 are those where m is 2 or 3 ; and r 1 , r 2 , r 3 , r 4 are hydrogen ; r 7 and r 9 are hydrogen ; and r 8 is hydrogen , hydroxy , halogen or alkoxy . more particularly preferred compounds of formula 4 are those where m is 2 or 3 ; and r 1 , r 2 , r 3 , r 4 are hydrogen ; r 7 and r 9 are hydrogen ; and r 8 is hydrogen , hydroxy or methoxy . the present invention also encompasses compounds of formula 5 : ## str7 ## wherein : r 1 , r 2 , r 3 , r 4 and r 7 , r 8 and r 9 are the same or different and represent hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; where x carbon , r 6 represents hydrogen , halogen , hydroxy , lower alkyl having 1 - 6 carbon atoms , or lower alkoxy ; and where x is nitrogen , r 6 represents an electron pair ; where y is carbon , r 10 represents hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; and where y is nitrogen , r 10 represents an electron pair ; r 7 and r 8 together optionally represent a benzo ring optionally substituted with up to four substitutents selected from hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy . preferred compounds of formula 5 are those where m is 2 , 3 or 4 and n is 0 . particularly preferred compounds of formula 5 are those where r 12 is hydrogen or alkyl ; m is 2 , n is 0 ; z is ch 2 ; r 1 , r 2 , r 3 , r 4 are hydrogen ; r 7 and r 9 are hydrogen ; and r 8 is hydrogen , hydroxy , halogen or alkoxy . more particularly preferred compounds of formula 5 are those where r 12 is hydrogen or methyl ; m is 2 ; n is 0 ; z is ch 2 ; and r 1 , r 2 , r 3 , r 4 are hydrogen ; r 7 and r 9 are hydrogen ; and r 8 is hydrogen , hydroxy or methoxy . in addition , the present invention provides compounds of formula 6 : ## str8 ## wherein : r 1 , r 2 , r 3 , r 4 and r 8 are the same or different and represent hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; r 6 and r 10 independently represent hydrogen , halogen , hydroxy , lower alkyl , or lower alkoxy ; preferred compounds of formula 6 are those where m is 2 , 3 or 4 and n is 0 . particularly preferred compounds of formula 6 are those where r 12 is hydrogen or alkyl ; m is 2 , n is 0 ; z is ch 2 ; r 1 , r 2 , r 3 , r 4 are hydrogen ; and r 8 is hydrogen , hydroxy , halogen or alkoxy . more particularly preferred compounds of formula 6 are those where r 12 is hydrogen or methyl ; r 6 is hydrogen ; r 10 is hydrogen or lower alkoxy , preferably methoxy ; m is 2 ; n is 0 ; z is ch 2 ; and r 1 , r 2 , r 3 , r 4 are hydrogen ; and r 8 is hydrogen , hydroxy or methoxy . representative ## str9 ## groups of formula 1 above include the following : ## str10 ## preferred ## str11 ## groups of formula 1 above include the following : ## str12 ## representative compounds of the present invention , which are encompassed by formula 1 , include , but are not limited to the compounds shown below in table 1 and their pharmaceutically acceptable salts . non - toxic pharmaceutically acceptable salts include salts of acids such as hydrochloric , phosphoric , hydrobromic , sulfuric , sulfinic , formic , toluene sulfonic , hydroiodic , acetic and the like . those skilled in the art will recognize a wide variety of non - toxic pharmaceutically acceptable addition salts . the present invention also encompasses the acylated prodrugs of the compounds of formula 1 . those skilled in the art will recognize various synthetic methodologies which can be employed to prepare non - toxic pharmaceutically acceptable addition salts and acylated prodrugs of the compounds encompassed by formula 1 . by &# 34 ; aryl &# 34 ; and &# 34 ; ar &# 34 ; is meant an aromatic carbocyclic group having a single ring ( e . g ., phenyl ), multiple rings ( e . g ., biphenyl ), or multiple condensed rings in which at least one is aromatic , ( e . g ., 1 , 2 , 3 , 4 - tetrahydronaphthyl , naphthyl , anthryl , or phenanthryl ), which can optionally be unsubstituted or substituted with e . g ., halogen , lower alkyl , lower alkoxy , lower alkylthio , trifluoromethyl , lower acyloxy , aryl , heteroaryl , and hydroxy . by &# 34 ; alkyl &# 34 ; and &# 34 ; lower alkyl &# 34 ; is meant straight and branched chain alkyl groups having from 1 - 6 carbon atoms . by &# 34 ; lower alkoxy &# 34 ; and &# 34 ; alkoxy &# 34 ; is meant straight and branched chain alkoxy groups having from 1 - 6 carbon atoms . by &# 34 ; heteroaryl &# 34 ; is meant 5 , 6 , or 7 membered aromatic ring systems having at least one hetero atom selected from the group consisting of nitrogen , oxygen and sulfur . examples of heteroaryl groups are pyridyl , pyrimidinyl , pyrrolyl , pyrazolyl , pyrazinyl , pyridazinyl , oxazolyl , furanyl , quinolinyl , isoquinolinyl , thiazolyl , and thienyl , which can optionally be unsubstituted or substituted with e . g ., halogen , lower alkyl , lower alkoxy , lower alkylthio , trifluoromethyl , lower acyloxy , aryl , heteroaryl , and hydroxy . by alkylsulfonyl is meant a sulfonyl group substituted with a lower alkyl group . by arylalkylsulfonyl is meant a sulfonyl group substituted with an arylalkyl group . by aminosulfonyl is meant a sulfonyl group substituted with an amino group . by alkylaminosulfonyl is meant a sulfonyl group substituted with a lower alkylamino , or di - lower alkylamino group . representative examples of bridged 4 - phenyl - 2 - aminomethylimidazoles according to the invention are shown in table 1 below . the pharmaceutical utility of compounds of this invention are indicated by the following assays for dopamine receptor subtype affinity . pellets of cos cells containing recombinantly produced d2 or d3 receptors from african green monkey were used for the assays . the sample is homogenized in 100 volumes ( w / vol ) of 0 . 05m tris hcl buffer at 4 ° c . and ph 7 . 4 . the sample is then centrifuged at 30 , 000 × g and resuspended and rehomogenized . the sample is then centrifuged as described and the final tissue sample is frozen until use . the tissue is resuspended 1 : 20 ( wt / vol ) in 0 . 05m tris hcl buffer containing 100 mm nacl . incubations are carried out at 48 ° c . and contain 0 . 4 ml of tissue sample , 0 . 5 nm 3 h - ym 09151 - 2 and the compound of interest in a total incubation of 1 . 0 ml . nonspecific binding is defined as that binding found in the presence of 1 mm spiperone ; without further additions , nonspecific binding is less than 20 % of total binding . the binding characteristics of examples of this patent for the d2 and d 3 receptor subtypes are shown in table 2 for rat striatal homogenates . table 2______________________________________compound number . sup . 1 d . sub . 2 k . sub . i ( mm ) d3 k . sub . i ( mm ) ______________________________________1 2 . 380 & gt ; 1002 1 . 420 & gt ; 1003 1 . 937 & gt ; 100______________________________________ . sup . 1 compound numbers relate to compounds shown in table 1 above . clonal cell lines expressing the human dopamine d 4 receptor subtype were harvested in pbs and the cells centrifuged and the pellets stored at - 80 ° c . until used in the binding assay . the pellets were resuspended and the cells lysed at 4 ° c . in 50 mm tris ph 7 . 4 buffer containing 120 mm nacl , 1 mm edta and 5 mm mgcl 2 . the homogenate is centrifuged at 48000 × g for 10 minutes at 4 ° c . the resulting pellet is resuspended in fresh buffer and centrifuged again . after resuspension of the pellet in fresh buffer a 100 ml aliquot is removed for protein determination . the remaining homogenate is centrifuged as above , the supernatant removed and the pellet stored at 4 ° c . until needed at which time it is resuspended to a final concentration of 625 mg / ml ( 250 mg per sample ) with 50 mm tris buffer ( ph 7 . 4 ) and 120 mm nacl just prior to use . incubations were carried out for 60 minutes at 25 ° c . in the presence of 0 . 1 nm 3 h ! ym - 09151 - 2 . the incubation was terminated by rapid filtration through whatman gf / c filters and rinsed with 2 × 4 ml washes of chilled 50 mm tris ( ph 7 . 4 ) and 120 mm nacl . non - specific binding was determined with 1 mm spiperone and radioactivity determined by counting in an lkb beta counter . binding parameters were determined by non - linear least squares regression analysis , from which the inhibition constant ki could be calculated for each test compound . the binding characteristics of some examples of this invention are shown in table 3 for the dopamine d 4 binding assay . in general , compounds of the accompanying examples were tested in the above assay , and all were found to possess a ki value for the displacement of 3 h ! ym - 09151 - 2 from the human dopamine d 4 receptor subtype of below 500 nm . some specific data is indicated in table 3 . table 3______________________________________compound number . sup . 1 k . sub . i ( mm ) ______________________________________1 0 . 0122 0 . 0703 0 . 100______________________________________ . sup . 1 compound numbers relate to compounds shown in table 1 above . compounds 1 and 2 are particularly preferred embodiments of the present invention because of their profile in binding to dopamine receptor subtypes . the compounds of general formulas 1 may be administered orally , topically , parenterally , by inhalation or spray or rectally in dosage unit formulations containing conventional non - toxic pharmaceutically acceptable carriers , adjuvants and vehicles . the term parenteral as used herein includes subcutaneous injections , intravenous , intramuscular , intrasternal injection or infusion techniques . in addition , there is provided a pharmaceutical formulation comprising a compound of general formula 1 and a pharmaceutically acceptable carrier . one or more compounds of general formula 1 may be present in association with one or more non - toxic pharmaceutically acceptable carriers and / or diluents and / or adjuvants and if desired other active ingredients . the pharmaceutical compositions containing compounds of general formula 1 may be in a form suitable for oral use , for example , as tablets , troches , lozenges , aqueous or oily suspensions , dispersible powders or granules , emulsion , hard or soft capsules , or syrups or elixirs . compositions intended for oral use may be prepared according to any method known to the art for the manufacture of pharmaceutical compositions and such compositions may contain one or more agents selected from the group consisting of sweetening agents , flavoring agents , coloring agents and preserving agents in order to provide pharmaceutically elegant and palatable preparations . tablets contain the active ingredient in admixture with non - toxic pharmaceutically acceptable excipients which are suitable for the manufacture of tablets . these excipients may be for example , inert diluents , such as calcium carbonate , sodium carbonate , lactose , calcium phosphate or sodium phosphate ; granulating and disintegrating agents , for example , corn starch , or alginic acid ; binding agents , for example starch , gelatin or acacia , and lubricating agents , for example magnesium stearate , stearic acid or talc . the tablets may be uncoated or they may be coated by known techniques to delay disintegration and absorption in the gastrointestinal tract and thereby provide a sustained action over a longer period . for example , a time delay material such as glyceryl monosterate or glyceryl distearate may be employed . formulations for oral use may also be presented as hard gelatin capsules wherein the active ingredient is mixed with an inert solid diluent , for example , calcium carbonate , calcium phosphate or kaolin , or as soft gelatin capsules wherein the active ingredient is mixed with water or an oil medium , for example peanut oil , liquid paraffin or olive oil . aqueous suspensions contain the active materials in admixture with excipients suitable for the manufacture of aqueous suspensions . such excipients are suspending agents , for example sodium carboxymethylcellulose , methylcellulose , hydropropylmethylcellulose , sodium alginate , polyvinylpyrrolidone , gum tragacanth and gum acacia ; dispersing or wetting agents may be a naturally - occurring phosphatide , for example , lecithin , or condensation products of an alkylene oxide with fatty acids , for example polyoxyethylene stearate , or condensation products of ethylene oxide with long chain aliphatic alcohols , for example heptadecaethyleneoxycetanol , or condensation products of ethylene oxide with partial esters derived from fatty acids and a hexitol such as polyoxyethylene sorbitol monooleate , or condensation products of ethylene oxide with partial esters derived from fatty acids and hexitol anhydrides , for example polyethylene sorbitan monooleate . the aqueous suspensions may also contain one or more preservatives , for example ethyl , or n - propyl p - hydroxybenzoate , one or more coloring agents , one or more flavoring agents , and one or more sweetening agents , such as sucrose or saccharin . oily suspensions may be formulated by suspending the active ingredients in a vegetable oil , for example arachis oil , olive oil , sesame oil or coconut oil , or in a mineral oil such as liquid paraffin . the oily suspensions may contain a thickening agent , for example beeswax , hard paraffin or cetyl alcohol . sweetening agents such as those set forth above , and flavoring agents may be added to provide palatable oral preparations . these compositions may be preserved by the addition of an anti - oxidant such as ascorbic acid . dispersible powders and granules suitable for preparation of an aqueous suspension by the addition of water provide the active ingredient in admixture with a dispersing or wetting agent , suspending agent and one or more preservatives . suitable dispersing or wetting agents and suspending agents are exemplified by those already mentioned above . additional excipients , for example sweetening , flavoring and coloring agents , may also be present . pharmaceutical compositions of the invention may also be in the form of oil - in - water emulsions . the oily phase may be a vegetable oil , for example olive oil or arachis oil , or a mineral oil , for example liquid paraffin or mixtures of these . suitable emulsifying agents may be naturally - occurring gums , for example gum acacia or gum tragacanth , naturally - occurring phosphatides , for example soy bean , lecithin , and esters or partial esters derived from fatty acids and hexitol , anhydrides , for example sorbitan monoleate , and condensation products of the said partial esters with ethylene oxide , for example polyoxyethylene sorbitan monoleate . the emulsions may also contain sweetening and flavoring agents . syrups and elixirs may be formulated with sweetening agents , for example glycerol , propylene glycol , sorbitor or sucrose . such formulations may also contain a demulcent , a preservative and flavoring and coloring agents . the pharmaceutical compositions may be in the form of a sterile injectable aqueous or oleaginous suspension . this suspension may be formulated according to the known art using those suitable dispersing or wetting agents and suspending agents which have been mentioned above . the sterile injectable preparation may also be sterile injectable solution or suspension in a non - toxic parentally acceptable diluent or solvent , for example as a solution in 1 , 3 - butanediol . among the acceptable vehicles and solvents that may be employed are water , ringer &# 39 ; s solution and isotonic sodium chloride solution . in addition , sterile , fixed oils are conventionally employed as a solvent or suspending medium . for this purpose any bland fixed oil may be employed including synthetic mono or diglycerides . in addition , fatty acids such as oleic acid find use in the preparation of injectables . the compounds of general formula 1 may also be administered in the form of suppositories for rectal administration of the drug . these compositions can be prepared by mixing the drug with a suitable non - irritating excipient which is solid at ordinary temperatures but liquid at the rectal temperature and will therefore melt in the rectum to release the drug . such materials are cocoa butter and polyethylene glycols . compounds of general formula 1 may be administered parenterally in a sterile medium . the drug , depending on the vehicle and concentration used , can either be suspended or dissolved in the vehicle . advantageously , adjuvants such as local anaesthetics , preservatives and buffering agents can be dissolved in the vehicle . dosage levels of the order of from about 0 . 1 mg to about 140 mg per kilogram of body weight per day are useful in the treatment of the above - indicated conditions ( about 0 . 5 mg to about 7 g per patient per day ). the amount of active ingredient that may be combined with the carrier materials to produce a single dosage form will vary depending upon the host treated and the particular mode of administration . dosage unit forms will generally contain between from about 1 mg to about 500 mg of an active ingredient . it will be understood , however , that the specific dose level for any particular patient will depend upon a variety of factors including the activity of the specific compound employed , the age , body weight , general health , sex , diet , time of administration , route of administration , and rate of excretion , drug combination and the severity of the particular disease undergoing therapy . the compounds of the invention may be prepared by the reactions shown below in scheme 1 . those having skill in the art will recognize that the starting materials may be varied and additional steps employed to produce other compounds encompassed by the present invention . ## str19 ## where the a ring is as defined above and nr a r b represents the group ## str20 ## wherein cr &# 39 ; r &# 34 ;, k , r 11 , r 12 , r 13 , ar , and m and n are as defined above . the invention is further illustrated by the following examples which are not to be construed as limiting the invention in scope or spirit to the specific procedures and compounds described therein . to a solution of trimethyloxonium tetrafluoroborate ( 2 . 20 g , 14 . 9 mmol ) in ( ch 2 cl 2 , 20 ml ) was added a solution of phthalimidine ( 1 . 8 g , 13 . 5 mmol ) in ch 2 cl 2 ( 20 ml ) and the solution was stirred for 24 h . the solvent was evaporated in vacuo and the residue was dissolved inchloroform ( 80 ml ). to this solution was added 1 -( aminoethyl )- 4 -( 2 - pyrimidinyl ) piperazine ( 2 . 08 g , 9 . 0 mmol ) followed by triethylamine ( 5 ml ). the solution was boiled under reflux overnight and then the solvent was evaporated in vacuo to afford a semisolid residue . the residue was dissolved in water ( 100 ml ) and extracted with ethyl acetate ( 3 × 100 ml ) to remove unreacted phthalimidine and primary amine . the aqueous solution was adjusted to about 20 % naoh by slow addition of aqueous 50 % naoh and then extracted with chloroform ( 2 × 100 ml ). the combined chloroform extracts were dried ( k 2 co 3 ) and evaporated to give compound 1 as a pale yellow oil ( 2 . 9 g , quantitative ). the hydrobromide salt was crystallized from hot ethanol . this compound had a melting point of 292 °- 295 ° c . ( dec .). to a solution of trimethyloxonium tetrafluoroborate ( 1 . 10 g , 7 . 45 mmol ) in ( ch 2 cl 2 , 10 ml ) was added a solution of phthalimidine ( 0 . 9 g , 6 . 75 mmol ) in ch 2 cl 2 ( 10 ml ) and the solution was stirred for 24 h . the solvent was evaporated in vacuo and the residue was dissolved inchloroform ( 40 ml ). to this solution was added 3 -( aminopropyl )- 4 -( 2 - pyrimidinyl ) piperazine ( 1 . 1 g , 4 . 5 mmol ) followed by triethylamine ( 5 ml ). the solution was boiled under reflux overnight and then the solvent was evaporated in vacuo to afford a semisolid residue . the residue was dissolved in water ( 50 ml ) and extracted with ethyl acetate ( 3 × 50 ml ) to remove unreacted phthalimidine and primary amine . the aqueous solution was adjusted to about 20 % naoh by slow addition of aqueous 50 % naoh and then extracted with chloroform ( 2 × 50 ml ). the combined chloroform extracts were dried ( k 2 co 3 ) and evaporated to give compound 2 as a pale yellow oil ( 0 . 75 g , 38 %). the hydrobromide salt crystallized from hot ethanol : mp 149 °- 150 ° c . ; base 1 h - nmr ( cdcl3 ) 8 . 38 ( d , 2h ), 7 . 3 - 7 . 5 ( m , 5h ), 6 . 55 ( t , 1h ), 4 . 62 ( s , 2h ), 3 . 9 ( m , 4h ), 3 . 63 ( m , 2h ), 2 . 63 ( m , 6h ), 1 . 8 ( m , 2h ). the following compounds are prepared essentially according to the procedures set forth above in examples 1 and 2 . ( c ) 1 -( n - 3 -{ 1 -( 4 -( 2 - pyridyl ) piperazinyl )} propylamino !) aminoisoindole dihydrobromide , compound 5 , m . p . 283 °- 285 ° c . ( dec .). the disclosures in this application of all articles and references , including patents , are incorporated herein by reference . the invention and the manner and process of making and using it are now described in such full , clear , concise and exact terms as to enable any person skilled in the art to which it pertains , to make and use the same . it is to be understood that the foregoing describes preferred embodiments of the present invention and that modifications may be made therein without departing from the spirit or scope of the present invention as setforth in the claims . to particularly point out and distinctly claim the subject matter regarded as invention , the following claims conclude the specification .