high energy electron beams have been proposed for use with an ims ( vip sources for ion mobility spectrometry h .- r . during , g . arnoldl , v . l . budovich , bruker saxonia analytik gmbh , leipzig , germany and chromdet analytical instruments , moscow , russia ). the advantages of using electron beams are pulsed operation , high instantaneous and average currents ( related to dose rates ) and capability for varying the current . the use of high current dose rate results in high reactive ion density . a high reactive ion density is good in that it is possible to decrease the minimum detection limit ( mdl ), by ionizing a larger fraction of the molecules of interest . however , to our knowledge , the advantage of using e - beam ionization has not ever been realized . the apparent failure to realize this advantage may be due to space charge effects in the drift region . conventional ims devices , as well as an e - beam enhanced one , are shown in fig3 a and 3 b . a conventional , prior art ion mobility spectrometer is shown in fig3 a . an ion mobility spectrometer 10 includes a sample inlet 12 , a gas outlet 14 and a drift gas inlet 16 . a radioactive source 18 generates ions 20 that encounter a detector 22 . a gate grid or shutter 24 is also provided . an embodiment of the ion mobility spectrometer according to the present invention is shown in fig3 b . instead of a radioactive source 18 , an electron beam source 26 is provided . the electron beam passes through an e - beam window 28 into a primary ionization region 30 . as will be described more completely below , the spectrometer of the invention includes an ion pre - concentrator 32 . a preferred embodiment involves an electron beam that would not have the drawbacks of high voltage . the possibility of miniaturizing the device is severely compromised by the use of high voltage ( feedthroughs are heavy , transformer need high voltage dielectric , which makes them large and heavy ). at the same time , high energies are desirable . with high energies , it is possible to increase the thickness of the window through which the electrons need to flow , easing the vacuum tightness issues . in addition , the high energy results in increased penetration length of the electrons into the sample gas . the requirements can be met by the use of rf acceleration . three types of accelerators can be considered : the first one uses cyclotron resonance in a magnetic field ( electron cyclotron ), the second one uses linear accelerators ( linac ), and the third one incorporates a high voltage transformer inside an evacuated cavity where the electron beam is being produced . the first one , the electron cyclotron accelerators , can be made by the use of an rf cavity , a microwave source , a low field magnet , a high vacuum tube and appropriate electron injection . thus , if an evacuated cavity is placed in a ˜ 300 gauss field , with electron injection at a point or line location , the electrons would be continuously accelerated by the application of an rf field at 900 mhz . at this frequency , high efficiency , high power , solid state , components exist . the electrons are extracted from the source at relatively high energy , using the fact that as the energy of the electrons increases , the gyro radius of the electron motion increases . the window location would therefore determine the energy of the extracted electrons . such a device would trade off the high voltage for the requirement of a low field permanent magnet and compact , high efficiency amplifier module ( with powers on the order of about 10 w ). the second source , the electron linac , uses an rf cavity , with proper injection of the electrons , to provide acceleration . the rf cavity should be replaced with a slow wave structure because of the low velocity of the electrons with respect to the speed of light . the third electron source avoids the need of the high voltage feedthrough and the transformer dielectric requirements by operating the transformer at high frequencies and in vacuum . the current can be limited by the use of a photocathode . this unit has to be operated in a pulsed mode , since the accelerating voltage reverses direction . the frequency of the power supply can be adjusted to match the optimal ionization rate . the material of the electron beam extraction window needs to satisfy multiple requirements . it has to be non - permeable to gases to maintain the vacuum , strong enough so that it can support the large pressure differential ( atmospheric on one side and vacuum on the other ), and has to have high thermal conductivity in order to remove the heat deposited by the electrons . the material should be such that electron loss energy in the window is minimized . it has to be thin to maximize transmission , but thick enough for preventing gas permeation . if it is very thin , it needs to be supported by a high transparency “ hibachi ” type grid to minimize stress and strains . low - z materials such as epitaxially grown diamond , beryllium and sapphire are attractive window materials ( high thermal conductivity , made with low - z materials and high strength ). not described in u . s . pat . nos . 5 , 969 , 349 , 6 , 429 , 426 and 6 , 586 , 729 is the use of cold field emission cathodes . the use of a thermal emission cathode is unattractive . the thermo - ionic cathode requires a power supply at high voltage requiring substantial power . a cold emission cathode is thus very attractive for the present application . the photocathode , described in u . s . pat . no . 5 , 969 , 349 , requires a light source , but allows for a simple way to control the current . the difficulties associated with the space charge in the drift region can be avoided by using a preconcentrator that minimizes the ions that are not of interest ( usually low mass ions with high mobility , including the reactive ions ), while increasing the fraction of the product ions of interest . thus , in the drift region mainly the product ions are injected and separated , minimizing the space charge associated with higher mobility reactive ions , a problem especially pronounced during the initial phases of the separation process . this is because directly downstream from the shutter grids the drifting ion bunches are all superimposed on each other ( not separated axially ), while further downstream from the shutter grid the different ions separate axially , as different ions drift with different speeds . the desired preconcentration can be achieved by using appropriately varying electric fields in the region upstream from the shutter grids . pulsing the electric fields in a manner that is either symmetric or asymmetric can be used to preferentially concentrate the product ions in the region of the grid . the applied fields need to be generated between multiple grids , upstream from the shutter grid . fig4 shows a schematic of the process . first , grid a , upstream from the shutter grid , shuts off all positive ions , as shown in fig4 ( a ). then grid a admits positive ions , as shown in ( b 1 ) and ( b 2 ), to the point where the slow positive ions have made it all the way to the shutter grid ( b 2 ), and some of the high mobility positive ions have been collected and neutralized by the shutter grid . at this point , the field is reversed , fig4 ( c 1 ) and ( c 2 ). all ions start to move back , but as shown in ( c 2 ) all fast positive ions have been removed from the regions between the grid a and the shutter grid , with only slow mobility positive ions remaining . a similar technique ( with reversed electric fields ) can be used to separate negative ions . means of implementation of the multiple grids , including preferred embodiments , are discussed later in this specification . multiple preconcentrating regions can be used . thus , an array of grids as shown in fig5 can be used to eliminate the high mobility ions from multiple regions . the case of two preconcentrating regions is schematically shown in fig5 . fig5 ( a ) corresponds to the end point of the preconcentration event in fig4 ( c 2 ). the ions are shifted in fig5 ( b 1 ) and 5 ( b 2 ) to the preconcentration cell b from preconcentration cell a by appropriate use of electric fields . once the ions are in the preconcentration cell b , the ions can be maintained there by appropriate oscillation of the electric field ( since diffusion is small ), while the preconcentrator a can be used again for separating other ions . the process can be repeated , and the ion bunches “ joined ” in preconcentrator b . to first order , the length of the ion bunch in preconcentrator b is equal to the final size of the ion bunch in preconcentrator a times the number the bunches that have been introduced ( i . e ., the bunches in preconcentrator b are concatenated , added up head - to - tail , as opposed to superimposed ). nonlinearity in the mobility of different ion species can be used to aid in the preconcentration . mobility is defined as the ratio between the ion velocity and the applied electric field , and it is constant only in the region where the velocity is linear with respect to the field . a schematic of the nonlinear behavior of the ion velocities as a function of the applied electric field is shown in fig6 . for particles of type 1 , the effective mobility decreases at the higher electric fields , while the opposite is true for ions of type 2 . for ions of type 3 , the effective mobility increases at the intermediate fields but then decreases at the higher fields . for example , assume that the high mobility ions have a mobility that increases with electric field , such as ions of type 2 . then in the process of removing the high mobility ions from the preconcentration region shown in fig4 ( c 1 ), the fast ions move relatively faster out of the preconcentration region than moving in . the ratio vfast / vslow is larger during the depopulation of the preconcentration region ( fig4 ( c )) than during the population time ( fig4 ( b )). as a consequence , more of the slow ions are retained in the preconcentration region . a preferred method would be to vary the electric field by applying an appropriate waveform . ac fields in this region can be used to preferentially move the reactive ions of no interest away from the region of interest next to the shutter grid . the preconcentration is thus achieved by using either linear or nonlinear mobilities of the reactive ions and the heavier ones that are of interest . the separation motion in this case is with the electric field parallel to the main direction of the ions . although sinusoidal drive of the electric field could be used , better results can be achieved by using higher harmonics , even a non - symmetric square wave . an illustrative example is shown in fig7 a and 7 b . the ratio between v 1 to v 2 can be adjusted to achieve optimum preconcentration that depends on the nature of the background gas and other contaminants present in the gas stream . it is not necessary to have the applied electric field average to 0 , that is , it may be better to have a dc value to the applied electric field . the preconcentration would move the product ions of interest to the region close to the shutter grid . if the ions were to reach the shutter grid region , the ions would strike the grid and lose their charge in the grid ( the grid would collect the ions ). by adjusting the frequency of the field and the shape of the waveform ( positive and negative values , and average values ), it is possible to have the product ions of interest move in and out of the region near the grid , avoiding the loss of most of the product ions of interest . the grid can be used to collect and neutralize the ions that are not of interest ( the reactive ions ). preconcentrating ions of interest for a finite amount of time in the preconcentrator has additional advantages . the ions can be kept there for allowing chemistry , if it is advantageous , with a well determined time . in addition , if multiple ions of close mobilities are present , asymmetric fields can be used to take advantages of non - linear mobilities to remove ions that are not of interest . thus additional separation / selectivity can be obtained . in addition to providing separation of the ions , the process puts the ions of interest next to the shutter grid . when the shutter is activated , only low mobility ions are accepted . thus , the process reduces the space charge due to faster ions , which are the bulk of the ions . care must be taken when moving ions through a grid . in principle , the electric field strength should remain constant or increase from one cell to the next in the direction of ion motion . decreasing the field strength from one cell to the next ( or through the shutter electrode ) results in substantial loss of ions . these ions are collected by the grids , and can contribute to “ memory ” effects in the detector . deposition of ions on the grids can be minimized by adequate control of the electric fields , as well as improved grid design , as will be described below . preconcentrating the ions of interest in a very small region right next to the shutter grid will also increase the resolution of the detected peaks by decreasing the opening time of the shutter grid . at typical operation of ims , with shutter speeds on the order of 100 - 200 microseconds , the width of the ion bunch accepted into the drift region is on the order of 1 mm . thus , no large loss of signal occurs if only a small fraction of the ions are preconcentrated , since most of the ions generated in the ionization region are lost anyway . in order to best introduce the ions into the drift region and to minimize distortions of the potential , a 2 - dimensional grid ( instead of grids made from parallel wires ) should be used . the grids can be made using advanced manufacturing techniques , such as rapid prototyping , micromachining or microlithography . thus , the grids can be patterned on both sides of a substrate that is removed afterwards in the central region , but leaving the outside of grid support . very accurate positioning of the grid elements can thus be obtained , with high transparency . care must be taken in order to assure that the grid material ends in tension , in order to prevent buckling of the grids . alternatively , grids can be made with insulator support , with channels through both the conducting and insulating regions . thus , an embodiment would involve using sio 2 insulator , deposition of si on it , followed by removal of material to make the channels , which should have a high fraction of open area . the process can be repeated with additional layers of sio 2 and si to make a grid array . the grid array could have 2 - dimensional features ( squares , hexagons , etc ), and they can be interleaved ( so that the features in the grids do not align in the axial direction ). this manner allows the manufacturing of the grid arrays with well developed use of si - based processes . this ims multigrid concept is illustrated in fig8 . the conventional shutter grids are shown as a and b . the other grids ( two shown c and d ) constitute the preconcentrating cell . fig9 shows the potential profile as produced by a set of grids , for a different set of voltages than those shown in fig2 . the grids are made of 0 . 05 mm parallel wires with a center - to - center wire distance of 0 . 5 mm . the grids are separated by 0 . 3 mm . the geometry is similar to that of fig2 , with the only difference being the applied voltages . voltages were chosen so that the value of the electric field across grid a is the same on both sides of the grid . as can be seen , little distortion of the electric field occurs because of finite size of the grid wires . the second grid in fig2 b , grid b , on the other hand , has an electric field that is higher on the left than on the right hand side . the difference in electric fields results in large distortions of the field , with a large number of the electric field lines terminating in the wires that make up the grid . thus , the presence of the grid does not much affect the potential distribution if the electric field is uniform across the grid . thus , it would be possible to establish the drift region fields using grids , instead of rings as is the common practice . the use of grids allows for a more uniform field to be established in the drift region , and thus minimize the growth of the pulses . in addition to the possibility of increasing the concentration of the product ions by means of a higher dose from the electron beam source , it would also be possible to selectively increase the ionization probability of a molecule of interest by tuning the energy of the secondary electrons in the background gas . this can be accomplished by using an electric field external to the electron beam ( as taught by u . s . pat . no . 5 , 256 , 854 , l . bromberg et al ., tunable plasma method and apparatus using radio frequency heating and electron beam irradiation ). one process of ionizing some molecules is through a dissociative ionization . this process is a function of the electron energy that attaches to the molecule . using an external electric field , one can tune the energy of the secondary electrons generated in the background gas to the optimum electron energy needed for dissociative ionization . the average electron energy is shown in fig1 as a function of the reduced electric field ( electric field divided by the concentration of neutral particles ). the average electron energy may range from 0 . 025 ev for no electric field ( corresponding to room temperature ) to 4 ev for the maximum electric field achievable without electrical breakdown ( corresponding to about 30 kv / cm at atmospheric pressure ). for a value of the reduced electric field of 0 . 8 - 8 townsends ( tn ), the average electron energy would be approximately 0 . 2 ev and 1 ev , respectively . the application of the electric field for adjusting the ionization could be used for any source of electrons . thus it can be used for conventional radioactive sources as well as with electron beams . the optimal “ tuning ” electric field for increasing the energy of the secondary electrons may be different from that optimal for preconcentrating the ions . in this case , an additional grid ( or any other means of establishing an electric potential ) may be used . since the primary electrons ( and therefore the secondary electrons , which are mainly present in the region where the primary electrons are ) are localized to a small region next to the electron source , the “ tuning ” electric field needs to be generated in a small region compared with the preconcentrating and drift regions . alternatively , the “ tuning ” field can be enhanced or decreased in the primary ionization region by proper shaping of the electrodes . in this case the “ tuning ” electric field in the primary ionization region will always be ratioed to the electric field in the preconcentrating region . the “ tuning ” electric field may be dc applied , or ac in order to minimize drift of the ions ( if the ac field is fast enough to prevent large drifts of the ions ). the “ tuning ” electric field can be asymmetric , as is the case with the preconcentrating field . fig1 shows an illustrative diagram with the “ tuning ” field in the primary ionization region along with the preconcentrating electric field . the electric fields can be applied in such a manner to prevent common mode interaction of the fields . use of electron sources has the advantage that the source of ionization can be modulated ( turned on and off , and can be varied ). pulsing on and off is useful for synchronous detection of the ions ( by using homodyne detection ). the electron e - beam can be modulated and synchronized with the detector , so that any background signal can be cancelled out . a drawback of this approach is that the electron source is distributed over a volume ( because of spread of the high energy electrons as they collide with the gas ions ), and the separation is performed in space . therefore , for the scheme to work , ionized gas volumes can not overlap . a method of collimating the electron beam so that the ionization region has limited length along the axis of the device is shown in fig1 . multiple vanes capture those electrons that have been scattered substantially in the axial direction . this electron loss will lead to the decrease in the strength of the source ( i . e ., the radiation dose to the gas ). the distance between the sets of vanes determines , to zeroth order , the size of the ion bunch . in order to prevent uncontrolled charging of the vanes , they need to be conducting . the ions are then extracted and drifted by the application of an axial electric field perpendicular to the direction of injection of the electron beam , as shown in fig1 . using variable ionization strength is useful for increasing the dynamic range of the device . for low concentrations , the ionization strength can be large , while for high concentrations , the ionization strength would be reduced . this has the advantage of varying the ion current in the drift region . in addition , by using high strength it is possible to have large sample gas flow rate , with improved time response . the much larger ionization produced by the electron source can produce saturation of the signal . as the electron source is increased , it is expected that the signal from the product ions increases . the concentration of the molecules of interest can be derived from the saturation of the signal with increasing ionization source . this could make ims devices much more useful , since present ims devices can not be used for quantification of the concentration . a controllable ionization source ( such as an electron beam or a corona discharge ) can be used for modulating the source of the ions . space charge in the ionization region can be minimized by pulsing the ion source . ions generated in this manner need to diffuse or drift in the presence of either an applied or self - generated field away from the ionization region , with the high mobility ions drifting or diffusing faster . thus another method of separation is possible . this has the advantage , besides decreasing space charge , of timing the chemistry . by timing the injection time into the preconcentrator with the pulsing of the ionization source , the time of interaction between the reactive ion products and the ions of interest can be adjusted for optimal detection ( sensitivity or selectivity ). the methods described above should allow the increase of ims sensitivity by a factor of 30 to 1000 relative to present technology , and selectivity by a factor of 10 . although the preferred method of ionization is through the use of electron beams , it should be clear to an expert in the field that the preconcentration technique can be used with any ionization source that results in large concentrations of ions , with high space charge . the contents of all of the patents and literature articles cited herein are incorporated into this specification by reference .