as a first example of the first formulation , the toothpaste composition contains chlorhexidine bigluconate in amount of 1 % by weight basis , i . e ., 5 . 2 % of 20 % solution of chlorhexidine bigluconate . the oil phase comprises 4 . 5 % medium chain triglycerides ( mct oil , crodamol ™ tgcc , manufactured by croda ) and 0 . 5 % soya lecithin ( leci pc 35 , lucas meyer ), weight ratio between lecithin and oil phase is 1 : 10 . to prevent lecithin oxidation an antioxidant , alpha - tocopherol acid hemisuccinate , has been found to be useful in the present formulation . it was added in amount of 0 . 02 %. as surfactant with high hlb value polysorbate - 20 ( tween - 20 ™, polyethoxylated sorbitan monolaurate , manufactured by croda ) in amount 1 % was employed . in order to provide prolonged retention of the formulation , a mucoadhesive polymer is employed according to this embodiment in the present invention . the mucoadhesive polymer , compatible with chlorhexidine , is hydroxypropylmethylcellulose , manufactured by the dow chemical company and sold under the trademark methocel e100m . this material has two functions : mucoadhesive properties development in concentration of 0 . 5 %, and a total 1 . 5 % was used for viscosity regulation . dibasic calcium phosphate was used as a mild abrasive and filler material in amount of 36 %. the material may readily be substituted by calcium carbonate or silicon dioxide ( milled zeolite ). colloidal silicon dioxide manufactured by cabot or degussa was used as a binding agent and added in amount from between 0 . 5 to 5 %, and preferably 1 . 8 %. flavoring agents may be employed and as example , dl - menthol may be added in an amount of between 0 . 1 and 1 . 0 % and preferably 0 . 2 %. as an alternative , peppermint oil or wintergreen oil may be used . variations in the formulation include glycerol which can be substituted ( partially or completely ) with liquid polyethylene glycol ( e . g ., peg - 400 ) or propylene glycol . for viscosity regulation , other non - ionic gel - forming polymers can be used instead of hpmc : hydroxyethylcellulose ( hec ), hydroxypropylcellulose ( hpc ), methylcellulose . if instead of dry sorbitol ( powder ) 70 % solution is used , the amount of added water must be recalculated according to the generic formulation . tween ™ can be readily substituted by another suitable non - ionic surfactant , examples of which include peg - 32 stearate , simulsol ™, cremophor ™ el - 35 , tefose ™, etc . it will be appreciated also that at least part of abrasive component can be replaced by titanium dioxide ( white pigment ) to obtain white toothpaste . ______________________________________toothpaste composition of example 1 manu - component type / grade facturer % ______________________________________chlorhexidine bigluconate usp20 % solutioncontains : chlorhexidine 1 . 04 % bigluconatewater 4 . 16 % purified water usp / nf 32 . 84 % glycerol usp / nf henkel 7 . 00 % sorbitol powder usp / nf roquette 8 . 00 % mct ( medium chain crodamol croda 4 . 50 % triglycerides ) oil tgccalpha - tocopherol hemisuccinate vitamin e eastman 0 . 02 % acid succinatelecithin ( leci pc 35p ) usp / nf lucas 0 . 50 % meyertween - 20 ™ ( polysorbate - 20 ) usp / nf croda 1 . 00 % hydroxypropylmethylcellulose methocel dow 1 . 50 %( hpmc ) e100m chemicaldibasic calcium phosphate nf mendell 36 . 00 % dihydratecolloidal silicon dioxide usp / nf cabot 1 . 80 %( cab - o - sil 300 ) dl - menthol or peppermint oil nf fluka 0 . 20 % na saccharinate usp / nf 0 . 20 % na benzoate nf 0 . 20 % total 100 % ______________________________________ in terms of preparation of 10 kg batch of the toothpaste , following to example , at first stage 2 . 5 g of the methocel e100 m was dispersed in 500 gram of purified water . this mixture was heated to 90 ° c . and stirred until the polymer was completely hydrated . two kilograms of cold water was added and stirred until complete dissolution . glycerol , in an amount of 700 g , was added and stirred until a homogenous solution was obtained . at a second stage of preparation , 50 g of lecithin and 2 g of vitamin e acid succinate and 20 g of peppermint oil or d , l - menthol were consequently added to 450 g of medium chain triglyceride oil ( crodamol tgcc ) and stirred slowly until clear solution was prepared . after complete dissolution , 100 g of non - ionic surfactant tween - 20tm was added and stirred for homogenous dispersion . this oil phase was combined with 520 g of 20 % chlorhexidine bigluconate solution followed by intensive stirring . in a further stage , the product from the second stage described above was mixed with the material from the first stage , using a high speed rotor - stator type mixer ( ultra - turrax ®, polytron ®), silverson ™ or similar type arrangements ) until a homogenous emulsion was formed . the formed emulsion was treated with high pressure homogenizer ( gaulin ®, microfluidizer ®, avestin ® or similar ) at predetermined pressure between 600 and 1200 bar . the emulsion was passed between one to three times through the homogenizer to obtain desired submicron emulsion . sodium saccharine in amount of 20 g and 20 g of sodium benzoate and 800 g of sorbitol were added to emulsion and stirred until completely dissolved . in the final stage , 147 . 5 g of hydroxypropylmethylcellulose was dispersed in 784 g of water . this mixture was heated to 90 ° c . and mixed well until all the methocel e100m was hydrated . the homogenized submicron emulsion was added to hydrated methocel at room temperature and mixed until polymer was homogeneously distributed . dibasic calcium phosphate was gradually added to formed mixture in amount of 3600 g . the mixture was stirred well and then approximately 180 g of colloidal silicon dioxide were gradually added until desired viscosity is achieved . the latter number represents a variable amount , this may be adjusted during manufacture to reach desired viscosity of the paste . the viscous mixture was then passed through 60 mesh screen , degassed in vacuum to remove entrapped air bubbles and packaged . a bioadhesive submicron emulsion based toothpaste with 0 . 3 % triclosan as antibacterial agent , and sodium monofluorphosphate as anti - caries additive for improved oral hygiene . in this example , triclosan arranges as a part of a mixture as a component in amount from 0 . 1 to 1 . 0 %, or most desirably 0 . 3 %. further , the triglyceride oil , an example of which is myritol 318 ™ manufactured by cospha - henkel , was incorporated into the mix in amount from between 2 . 0 to 20 %, and desirably 4 . 62 %. egg lecithin was used as additional emulgator , and high molecular weight caroxymethylcellulose was employed as bioadhesive polymer and also as viscosity regulating agent . sorbitol was used as 70 % solution . ______________________________________toothpaste composition for example 2 manu - phasecomponent type facturer % ______________________________________a triclosan usp / nf 0 . 30 % a mct oil myritol 318 cospha - 4 . 62 % henkela alpha - tocopherol eastman 0 . 02 % hemisuccinatea lecithin ( 80 % e - 80 lipoid 0 . 50 % phosphatidylcholine ) a tween - 80 ™ usp / nf 1 . 00 %( polysorbate - 80 ) a peppermint oil flavorchem 1 . 00 % b purified water 10 . 00 % b sorbitol 70 % nf 18 . 00 % b carboxymethylcellulose nf hercules 0 . 10 % 9m31xfc sorbitol 70 % 8 . 00 % c glycerol 96 % henkel 8 . 20 % c carboxymethylcellulose 0 . 90 % 9m31xfc dibasic calcium 30 . 00 % phosphate , dihydratec dibasic calcium 16 . 00 % phosphate , anhydr . c sodium mono - 0 . 76 % fluorphosphatec sodium sacharinate 0 . 25 % c sodium benzoate 0 . 10 % c sodium phosphate , usp / nf fluka 0 . 25 % tribasictotal 100 % ______________________________________ carboxymethylcellulose grade and amount can be adjusted according to desired paste final viscosity value . polyacrylic acid ( carbomer , carbopol ™), xantan gum ( keltrol ), hydroxypropylmethylcellulose ( hpmc ) and other polymers , such as hydroxyethylcellulose ( hec ), hydroxypropylcellulose ( hpc ), methylcellulose can be used for viscosity regulation . tween - 80 ™ can be replaced by another suitable non - ionic surfactant ( peg - 32 stearate , poloxamer , simulsol , cremophor , tefose , etc .). in formulation with triclosan up to 80 % of tween ™ can be replaced by sodium laurylsulfate ( sls ) or sodium laurylsarcosinate or mixture thereof . ph of the toothpaste , if necessary , can be adjusted to desired value , using sodium triphosphate and / or monophosphate . this example sets forth a toothpaste based on bioadhesive submicron emulsion with 1 % chlorhexidine bigluconate and 0 . 22 % sodium fluoride for oral hygiene . this formulation was prepared as example 1 , but part of dibasic calcium phosphate was substituted with 0 . 22 % sodium fluoride to achieve anti - caries properties . this formulation represents submicron emulsion based clear gel for oral hygiene with cetylpiridinium chloride and sodium fluoride . it was prepared by the same method as example 1 , but lipid phase of the submicron emulsion is prepared of isopropyl palmitate and soya lecithin s - 75 , cetylpiridinium chloride employed as antibacterial agent , and abrasive silica was selected to prepare clear gel . sodium fluoride is used as anti - caries agent . ______________________________________toothpaste composition for example 4component % ______________________________________glycerin 96 % 16 . 5isopropyl palmitate 5 . 8tocopherol peg1000 succinate 0 . 2lecithin s - 75 0 . 64tween - 20 ™ ( polysorbate - 20 ) 1 . 0peppermint oil / clove oil / anise oil flavor mix 1 . 0purified water 5 . 0peg - 400 8 . 0cetylpiridinium chloride 1 . 0colloidal silicon dioxide 8 . 0sorbitol 70 % 37 . 9hydroxypropylmethylcellulose methocel ® e15m 0 . 4abrasive silica ( milled zeolite ) 14 . 0sodium fluoride 0 . 22sodium saccharinate 0 . 24sodium benzoate 0 . 1total 100 . 0______________________________________ in this example , a toothpaste based on bioadhesive submicron emulsion with 0 . 3 % of triclosan . this formulation was prepared as example 2 , but the amount of carboxymethylcellulose 9m31xf was substituted with carbopol 934p , and ph was adjusted to 6 . 0 - 6 . 5 to achieve optimal bioadhesive properties of the submicron emulsion . the main advantage of bioadhesive submicron toothpaste is significantly extended presence of the active ingredients of the toothpaste in the mouth thus providing prolonged antiseptic action and better tooth protection . secondly , most of the antibacterial substance , e . g ., chlorhexidine , is located on the oil / water interface of the submicron emulsion , in accordance with thermodynamic properties and partition and free drug concentration in the water phase is significantly decreased . it leads to apparent improvement of the taste of such submicron emulsion compositions . further , is connected with better penetration of submicron particles inside the surface layer of the oral mucose in the mouth . flavor components , included in the oil droplets , better penetrate and supply better freshness in local application . last , but not least factor is significantly lower teeth staining with chlorhexidine toothpastes based on submicron emulsion compositions . formulation can be readily adjusted by those skilled in the art to numerous modifications , comprising different active components , flavors and another ingredients . although embodiments of the invention have been described above , it is not limited thereto and it will be apparent to those skilled in the art that numerous modifications form part of the present invention insofar as they do not depart from the spirit , nature and scope of the claimed and described invention .