text:
Study protocol
The impact of the HEART risk score in the early assessment of patients with acute chest pain: design of a stepped wedge, cluster randomised trial
Judith M Poldervaart1,
Johannes B Reitsma1,
Hendrik Koffijberg1,
Barbra E Backus1,
A Jacob Six2,
Pieter A Doevendans3 &
Arno W Hoes1
Chest pain remains a diagnostic challenge: physicians do not want to miss an acute coronary syndrome (ACS), but, they also wish to avoid unnecessary additional diagnostic procedures. In approximately 75% of the patients presenting with chest pain at the emergency department (ED) there is no underlying cardiac cause. Therefore, diagnostic strategies focus on identifying patients in whom an ACS can be safely ruled out based on findings from history, physical examination and early cardiac marker measurement. The HEART score, a clinical prediction rule, was developed to provide the clinician with a simple, early and reliable predictor of cardiac risk. We set out to quantify the impact of the use of the HEART score in daily practice on patient outcomes and costs.
Methods/Design
We designed a prospective, multi-centre, stepped wedge, cluster randomised trial. Our aim is to include a total of 6600 unselected chest pain patients presenting at the ED in 10 Dutch hospitals during an 11-month period. All clusters (i.e. hospitals) start with a period of 'usual care' and are randomised in their timing when to switch to 'intervention care'. The latter involves the calculation of the HEART score in each patient to guide clinical decision; notably reassurance and discharge of patients with low scores and intensive monitoring and early intervention in patients with high HEART scores. Primary outcome is occurrence of major adverse cardiac events (MACE), including acute myocardial infarction, revascularisation or death within 6 weeks after presentation. Secondary outcomes include occurrence of MACE in low-risk patients, quality of life, use of health care resources and costs.
Stepped wedge designs are increasingly used to evaluate the real-life effectiveness of non-pharmacological interventions because of the following potential advantages: (a) each hospital has both a usual care and an intervention period, therefore, outcomes can be compared within and across hospitals; (b) each hospital will have an intervention period which enhances participation in case of a promising intervention; (c) all hospitals generate data about potential implementation problems. This large impact trial will generate evidence whether the anticipated benefits (in terms of safety and cost-effectiveness) of using the HEART score will indeed be achieved in real-life clinical practice.
ClinicalTrials.gov 80-82310-97-12154.
Patients presenting with chest pain at the emergency department (ED) pose a diagnostic challenge. Chest pain can be a symptom of an acute coronary syndrome (ACS), i.e. acute myocardial infarction (AMI) or unstable angina, which is the case in approximately 20% of the patients and requires prompt treatment. In the remaining 80%, chest pain is caused by many other, usually not life-threatening, conditions [1]. Unfortunately, decision-making in chest pain patients is hampered by limited predictive power of patient characteristics, including signs, symptoms and additional tests [1–3]. Therefore, physicians face the challenge of not wanting to miss an ACS on the one hand, while avoiding too many unnecessary diagnostic procedures that can be time-consuming and patient burdening on the other hand. Currently, the fear of missing a relevant cardiac condition makes physicians cautious and, to be on the safe side, a large proportion of patients are kept in the hospital from several hours to days for monitoring or additional testing.
Diagnostic strategies in patients with chest pain therefore focus on identifying patients in whom ACS can be safely ruled out based on readily available clinical findings from history, physical examination and early marker measurement of cardiac damage. Recent guidelines suggest the use of well-developed and validated risk scores to stratify patients in the emergency room [4–6]. Several prognostic risk scores have been developed for patients diagnosed with ACS, such as the TIMI (Thrombolysis in Myocardial Infarction) risk score and the GRACE (Global Registry of Acute Cardiac Events) risk score [7–9]. However, scores that identify ACS in patients suspected of ACS in the emergency setting and predict short-term mortality or coronary intervention are not available. The HEART score has been specifically developed for risk stratification in all patients with chest pain presenting at the ED.
The HEART score incorporates all five important elements of clinical judgement in chest pain patients: History, ECG (electrocardiogram), Age, Risk factors and Troponin (see Table 1). Similar to the Apgar score, applied worldwide to assess the need for intensive care in new-borns [10], each of the five elements is appreciated with 0, 1 or 2 points. The sum of all five elements results in a score between 0–10, which can easily be calculated.
Table 1 Elements to calculate HEART score for chest pain patients at the emergency department
The HEART score has been externally validated in various patient populations with a total of 6174 patients and its predictive effectiveness has been demonstrated [11–14]. Table 2 depicts an overview of these validation studies. In the Dutch multicenter validation study, major adverse cardiac events (MACE) occurred in 1.7% (95% CI 1.18-2.22) of all patients with a HEART score of 3 or lower. This is comparable with the around 2% incidence of ACS among discharged chest pain patients reported in the literature [15, 16]. Importantly, none of the patients in the low-risk HEART category experienced unexpected sudden cardiac death in our validation studies. MACE occurred in 16.6% of all patients with intermediate HEART scores (4–6), and in 50.1% of all patients with high HEART scores (7–10). Similar results were observed in relevant patient subgroups, such as women, elderly or diabetics [12]. Notwithstanding these promising validation results, the impact of the use of the HEART score in daily clinical practice remains to be established. The HEART score provides the physician with a formal risk score and a recommendation whether a chest pain patient should be admitted or not. A safe and early discharge could potentially result in a significant reduction of patient burden, hospital admissions and health care costs.
Table 2 Summary of results of previous validation studies of the HEART score
Therefore, we designed the HEART Impact study to investigate whether the use of the HEART score in the management of chest pain patients indeed leads to these positive health effects, while not causing an increase in the occurrence of MACE.
Study design: stepped wedge randomised trial
We will use a prospective, stepped wedge cluster randomised trial [17, 18]. Our aim is to include 6600 unselected chest pain patients from 10 hospitals in the Netherlands during an 11-month period. Key study design features are shown in Figures 1 and 2. In a stepped wedge design, there is no randomisation at patient level, but hospitals will be randomised with respect to the timing at which they introduce the HEART score. See Figure 1. During the first month, all chest pain patients presenting to the ten hospitals will receive usual care. Then, during a 10-month period, each month one randomly allocated hospital will start to apply the HEART score (HEART period) and continue to do so until the end of the study. During the last month of the inclusion period all 10 hospitals will be using the HEART score.
The Stepped Wedge Design for the HEART Impact study.
Flow of study and data collection in usual care period and in HEART period. ED: emergency department. QoL:quality of life. EQ-5D: EuroQol Five-Dimensional. SF-36: short-form 36. iPCQ: productivity cost questionnaire. MACE: major adverse cardiac events.
'Usual care' and 'HEART' period
Usual care is defined as 'daily practice of the cardiologist or attending emergency doctor to diagnose a patient with chest pain'. In this period, attending doctors assess the risk based on their clinical skills, previous experiences, gut feeling and various other criteria (for example, described in European Society of Cardiology Guidelines [6]), without using the HEART score. No attempt was made to explicitly standardise usual care across all hospitals. The assessment will typically include: gender, age, medical (cardiac) history, symptoms, risk factors, and current drug use, physical examination with special attention for the heart and lungs, blood pressure, heart rate, blood tests, ECG, and any other diagnostic procedures the physician considers necessary. The standard blood tests include measurements of troponin, glucose levels, creatinin levels (with a calculated estimated glomerular filtration rate (eGFR) according to MDRD (modification of diet in renal disease)), haemoglobin, and any other blood test required. A standard 12-lead ECG is recorded by a trained employee of the ED and classified by a single cardiologist according to the Minnesota coding criteria. All investigations take place in the ED.
During the HEART period, the HEART score will be formally determined in all patients. Decision-making about whether to admit a patient, any further testing or treatment decisions will be carried out similarly to usual care, with the exception of the availability of the HEART score in each individual patient and the recommendations linked to that score. This is also known as "directive use" of a prediction rule, as opposed to "assistive use" where only the predicted risk is given to the physician [19]. The recommendation for patients with a HEART score of 3 or lower will be reassurance and discharge. In those low-risk patients who are discharged, a second troponin will be performed at home to identify any missed ACS. A similar approach of home visits performed by ambulatory lab services was successfully applied in our earlier study in suspected ACS in primary care [20]. Obviously, in accordance with daily practice, the attending physician may decide to overrule the recommendation corresponding to a low HEART score and admit a patient. In such a case, information about the reasoning for this escape will be collected. Patients with a HEART score in the intermediate range (4–6), will generally be admitted to the hospital for further observation and investigation. The high-risk group (7–10) will typically receive prompt (invasive) treatments.
Study population and recruitment
All patients above 18 years presenting with chest pain to the (cardiac) ED of 10 participating hospitals are eligible. Only patients presenting with evident ST-segment elevation myocardial infarction (STEMI) will be excluded, since there is no diagnostic dilemma in these patients. Typically, such patients are directly taken to the intervention room. In both study periods, information about the study procedure will be provided by the treating physician and written consent for the use of data and follow-up is obtained at the first appropriate moment after presentation at the ED. In the HEART period, no consent from the patient is needed for the use of the HEART score, for several reasons. First, the number of additional procedures for patients is minimal since the HEART score consists of elements that are collected routinely. Furthermore, the HEART score is proven to be safe, and is a decision support tool rather than a real intervention, with the possibility for physicians to override the recommendations provided by the rule. The study was approved by the Institutional Review Board, and subsequently by the Boards of the participating hospitals.
The HEART impact trial aims to measure both the intended positive changes as well as any unintended negative effects associated with the use of the HEART score. Patient outcomes, use of health care resources and costs will be determined in both periods.
Primary outcome: occurrence of MACE
The primary outcome is the 6-week occurrence of major adverse cardiac events (MACE), consisting of the following events: acute myocardial infarction (AMI), Percutaneous Coronary Intervention (PCI), Coronary Artery Bypass Grafting (CABG) surgery, or death due to any cause. To identify MACE after discharge, a phone-call will be made to all patients at home after 3 months. Any information that could indicate to possible endpoints will be further investigated through hospital charts, hospital discharge letters and information obtained from the patient's general practitioner (GP). In addition, the Central Bureau for Statistics (CBS) will be consulted for information on vital status as the cause of death of participants. All cases with possible endpoints are reviewed by two independent adjudicators for endpoint classification. This adjudication committee will evaluate all relevant information to decide, using ESC guidelines, whether MACE occurred. In case of disagreement between two adjudicators, the case is discussed in a plenary adjudication committee meeting until consensus is reached.
Secondary outcomes include the following:
The occurrence of MACE in the specific subgroup of patients with a low HEART score.
Use of health care resources. The number of hospital admissions/discharges, duration of hospital stay, duration of stay on the ED, number of readmissions and GP visits after discharge will be collected.
Health-related quality of life. This will be determined in a subset of approximately 1000 patients, in both time periods in five of the participating hospitals. Data on health-related quality of life are collected at baseline (at ED) using the EuroQol Five-Dimensional (EQ-5D) questionnaire, and a 2-week and at 3-month follow-up using the short form-36 (SF-36) and the EQ-5D questionnaires. SF-36 is a short-form health survey with only 36 questions. For this study, we will only use the 11 questions addressing Health. EQ-5D comprises the following 5 dimensions: mobility, self-care, usual activities, pain/discomfort and anxiety/depression. Furthermore, the EQ VAS (visual analogue scale) records the respondent's self-rated health on a vertical, visual analogue scale where the endpoints are labelled 'Best imaginable health state' and 'Worst imaginable health state'. Higher scores are associated with a better health-related quality of life.
Direct and indirect costs. These will be determined in a subset of approximately 1000 patients, in both time periods in five of the participating hospitals. Actual medical costs using a health-care provider's perspective are obtained in both the time periods. Medical resource use is extracted from the electronic hospital patient files. Unit cost prices will be determined in two participating hospitals, one academic and one peripheral hospital, using micro-costing if possible and top down costing otherwise. The iPCQ (Productivity Cost Questionnaire) will be used to collect quantitative data on the relation between illness, treatment and work performance. The iPCQ is divided into 3 modules: (1) reduced productivity at paid work due to work absenteeism, (2) reduced productivity at paid work without absence from work and (3) unpaid labour production.
An additional sample of blood will be collected from patients of two participating hospitals during the emergency visit for future biomarkers investigation (Biobanking).
The 6-week cumulative incidence of MACE in both the intervention and usual care period will be analysed at the patient level using a generalised linear mixed model (GLMM) [21]. Risk differences with corresponding 95% CIs will be estimated from this model. No baseline differences in prognostic factors between patients included in both periods are expected, but in case these do occur, covariates will be added to the GLMM model to adjust for these baseline differences. Differences in health-related quality of life at baseline, 2 weeks and at 3 months will also be assessed, separately for the different questionnaires. Costs per patient will be calculated according to Dutch guidelines for pharmaco-economic analyses [22], and costs of drugs prescribed will be based on Dutch formulary cost-prices.
The aim of the HEART study is to evaluate whether the use of the HEART score streamlines the further management of chest pain patients, in particular whether it can identify low-risk patients who can be discharged sooner than usual. However, these benefits become only relevant if the use of the HEART score does not lead to an increase in adverse cardiac events. Our sample size calculation is therefore based on demonstrating that proportion of patients with MACE is not inferior to the proportion observed with usual care. The proportion MACE expected during usual care is 17%. The non-inferiority margin is based on clinical judgement and available literature as 3%, thus accepting an upper limit of the 95% confidence interval (CI) during the intervention period of 20%. With 10 hospitals, inclusion of 60 patients per hospital per month, a between-hospital variation in incidence of 16 to 18%, a one-sided alpha of 5% and a power of 80%, 6600 patients with chest pain should be included in total. Taken into account our inclusion rates of previous validation studies and with special attention and encouragement for inclusion, we expect a realistic inclusion rate of 60 patients per hospital per month.
A cost-effectiveness analysis will be performed from a societal perspective, for a 3-month and a life-time time horizon. The 3-month time horizon corresponds to the actual follow-up period and will consider the observed differences in costs and quality of life. A GLMM will be used to assess cost-effectiveness, accounting for the randomisation of clusters instead of patients. Uncertainty will be addressed through the GLMM model which will be extended with cluster and patient-level covariates if baseline characteristics are imbalanced. The life-time horizon will be applied to account for long-term costs and effects of the observed MACE. Here, the observed risks of MACE, as well as the direct treatment cost and productivity losses estimated using the friction cost approach, will serve as input for a Markov decision-analytic model [23]. If necessary, additional evidence on long-term costs and effects of adverse events will be obtained from the literature. Monte Carlo simulation will be applied to simulate the course of hypothetical patients through the model, and to estimate the number of quality-adjusted life years and costs of both strategies. Costs will be discounted with 4% per annum, and effects with 1.5% per annum, according to Dutch guidelines. The incremental cost-effectiveness ratio and the net monetary benefit (for various willingness to pay thresholds) will be estimated for the HEART score compared with usual care. Uncertainty will be assessed with probabilistic sensitivity analysis [24], and results will be presented in incremental cost-effectiveness planes and cost-effectiveness acceptability curves.
Regulation statement
This study will be conducted according to the principles of the current version of the declaration of Helsinki and in accordance with the Dutch law on Medical Research Involving Human Subjects Act (WMO).
The study was approved by the Institutional Review Board (medical ethical committee of the University Medical Center Utrecht, the Netherlands), and subsequently by the Boards of the participating hospitals.
Clinical prediction rules, like any other health care intervention, need proper evaluation before wide-spread use in clinical practice. Two key steps in this evaluation include external validation and impact assessment. External validation studies can reveal several problematic issues associated with the use of a clinical prediction rule [25–27]. Firstly, the rule has been developed on a dataset that was too small in relation to the number of variables that have been considered. This increases the risk that particularities of the dataset will be modeled rather than robust relationships. The consequence is that the performance of the model will decrease when applied to new patients (external validation). This is known as over-fitting. Secondly, the rule has been derived in a population which does not match the population where clinicians would like to use the rule. Here, your prediction model may be developed statistically sound, but applied to a new population the performance may decrease meaningfully. However, even after proper development and good performance in validation studies, often clinical prediction rules are hardly or incorrectly used in daily practice, because of difficulties in application or because physicians are not convinced of its usefulness in clinical practice. This is especially the case when the outcome used in the rule has no direct relevance for clinical practice. For all these reasons, it is of vital importance to study the impact of a clinical prediction rule when applied in real-life practice. Increasingly, stepped wedge designs are applied to measure the impact of clinical decision rules in clinical practice [28]. The stepped wedge design combines elements of both the cluster randomised trial and the before-after design (see Figure 1). The stepped wedge design has several features that make this design attractive for such impact studies. These characteristics are outlined in Table 3. We chose the stepped wedge design as an informative, efficient and valid design to examine whether expected improvements in patient outcomes, use of health care resources, and costs can be achieved when implementing a health care intervention on a large scale.
Table 3 Overview of key characteristics of the stepped wedge design
It is of importance to generate valid evidence that the use of the HEART score compared to usual care is safe and leads to fewer admissions and diagnostic procedures in real-life clinical practice. Using the stepped wedge design, we can also monitor the process of implementation of a clinical support tool at the ED across hospitals that vary in size and population. Patient inclusion has started July 1st of 2013.
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We thank all participating hospitals, especially all (cardiac) residents, nurses, secretaries, R&D departments and local laboratories. Research grant was obtained from the "Netherlands Organization for Health Research and Development" (ZonMw grant Project number 171202015), as part of the Effectiveness Program (Doelmatigheidsprogramma ZonMw).
Julius Center for Health Sciences and Primary care, University Medical Center, Stratenum 6.131, PO box 85500, 3508AB, Utrecht, The Netherlands
Judith M Poldervaart, Johannes B Reitsma, Hendrik Koffijberg, Barbra E Backus & Arno W Hoes
Department of Cardiology, Zuwe Hofpoort Hospital, Woerden, The Netherlands
A Jacob Six
Department of Cardiology, University Medical Center Utrecht, Utrecht, The Netherlands
Pieter A Doevendans
Judith M Poldervaart
Johannes B Reitsma
Hendrik Koffijberg
Barbra E Backus
Arno W Hoes
Correspondence to Judith M Poldervaart.
AW, JB and AJ designed the study. JM, JB, H, and AW drafted the manuscript. All authors read and approved the final manuscript.
Poldervaart, J.M., Reitsma, J.B., Koffijberg, H. et al. The impact of the HEART risk score in the early assessment of patients with acute chest pain: design of a stepped wedge, cluster randomised trial. BMC Cardiovasc Disord 13, 77 (2013). https://doi.org/10.1186/1471-2261-13-77
HEART score
Clinical prediction rule
Risk score implementation
Stepped wedge design
Cluster randomised trial

redpajama_set_name: RedPajamaCommonCrawl


text:
Juan Carlos Heredia, né le  à Córdoba (Argentine), est un footballeur international espagnol qui jouait au poste d'attaquant. Il possède la double nationalité argentine et espagnole.

Biographie

Clubs

Juan Carlos Heredia débute dans le championnat argentin avec le club de Defensores de Belgrano en 1971. Il joue ensuite avec Rosario Central en 1972.

Heredia joue ensuite six saisons au FC Barcelone où il remporte la Coupe d'Espagne en 1978 et la Coupe des coupes en 1979.

Équipe nationale

Juan Carlos Heredia joue trois matchs avec l'équipe d'Espagne.

Il joue son premier match le  contre la Roumanie, match comptant pour les éliminatoires de l'Euro 1980.

Palmarès
Avec le FC Barcelone :
 Vainqueur de la Coupe d'Europe des vainqueurs de coupe en  1979
 Vainqueur de la Coupe d'Espagne en 1978

Références

Liens externes

Footballeur international espagnol
Footballeur argentin
Joueur du Club Atlético Belgrano
Joueur de l'Elche CF
Joueur du FC Barcelone
Joueur de River Plate
Entraîneur argentin de football
Naissance en mai 1952
Naissance à Córdoba (Argentine)

redpajama_set_name: RedPajamaWikipedia


This is a list of ancient dishes, foods and beverages that have been recorded as originating during ancient history. The span of recorded history is roughly 5,000 years, beginning with Sumerian Cuneiform script, the oldest discovered form of coherent writing from the protoliterate period around the 30th century BC.
Although the end date of ancient history is disputed, some Western scholars use the fall of the Western Roman Empire in 476 AD (the most used), the closure of the Platonic Academy in 529 AD, the death of the emperor Justinian I in 565 AD, the birth of Islam in 610 CE or the rise of Charlemagne as the end of ancient and Classical European history. This list does not contain entries that originated after ancient history.
Anfu ham is a dry-cured ham from Anfu, Jiangxi, China that originated from the Qin Dynasty. It is eaten alone and also used as an ingredient to add flavor to various dishes.
Babaofan or Eight Treasure Glutinous Rice was first created for a banquet celebrating King Wu of Zhou's defeat of the last King of the Shang Dynasty King Zhou of Shang in the Battle of Muye (circa 1123 BCE according to this article but 1046 BCE according to English Wikipedia article).
Chili pepper (hot peppers) – remains of wild peppers were found in the Tehuacan Valley, 250 kilometres (160 mi) south of Mexico City, Mexico that date back to 7,000 BC. The peppers were found in fossilized human coprolites (fossilized human feces).
Rice – existed, but was "little-used in the ancient world" outside of Asia.
Beer is recorded in the written history of Mesopotamia and ancient Egypt and is one of the world's oldest prepared beverages.
Kombucha originated in what is now Manchuria around 220 BCE, and is said to have been imported to Japan around 400 CE by the physician Kombu.
Wine consumption and production has been found through archaeological evidence as early as c. 6000 BC.
Millet – a staple food of ancient China, Egypt and India; Staple in Northern China before rice.
Maize - originated in Central America between 5600 and 4000 BCE.
Rice - originated in Southern China 8,200 - 13,500 years ago.
Teff - a native grain to Ethiopia and Eritrea that happened to be domesticated sometime between 8000 and 5000 BC.
Brânză– an ancient Romanian cheese dating to "before the time of the Romans"
Hummus first mentioned in a cookbook from Cairo, Egypt from the 13th century.
Kuluban – an ancient Javanese dish of boiled vegetables served in spices, similar with today urap. Mentioned in The Rukam inscription dated 829 Saka (907 CE) from Mataram kingdom ancient Java, Indonesia.
Lalab – vegetable dish called as rumwah-rumwah in ancient Java, Indonesia. Mentioned in The Panggumulan (Kembang Arum) inscription dated 824 Saka (902 CE) from Mataram kingdom.
Rawon – meat stew, mentioned as rarawwan in ancient Javanese Taji inscription (901 CE).
Rujak – spicy fruit dish, mentioned as rurujak in ancient Javanese Taji inscription (901 CE).
Krupuk – traditional cracker made from rice flour, mentioned as kurupuk in ancient Javanese Taji inscription (901 CE).
Tempeh - high protein fermented soy product from Indonesia. First known as kadêlê mentioned in an old Javanese manuscript Serat Sri Tanjung from the 12th to 13th century CE.
Nattō is prepared using fermented soybeans, and has been described as likely being an ancient food. Its origins have been described as unknown. Nattō may have been developed independently in different areas that have the same ingredients, such as Japan, China and Korea.
Nattō is typically consumed atop rice.
^ "The origin of sausage goes back to ancient times."
^ "An ancient food, soup is prepared by cooking meat, fish or vegetables and the like in such fluids as water or milk; it is then consumed as a liquid."
^ "Smy, or thickened milk, both human and animal, is often mentioned in medical prescriptions."
^ "Cheese is represented in the tomb art of ancient Egypt and in Greek literature"
^ "In the Pacific Islands, poi, made from taro root, is an ancient food that is preserved through fermentation."
^ "Chickpea is an ancient food crop in the Highlands, but whether it was domesticated indigenously is debatable. Ethiopian varieties are infertile when crossed with Near Eastern varieties. This genetic incompatibility may reflect distinct ecological ..."
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Don't worry Maverick, I'm back to post a new tab, so I think everyone will be very busy digging this one: Endless Despair II. One of the hardest tabs I've ever wrote, but every minute spent was worth it. Guitar Tuning: 7-string standard tuning (BEADGBE) Bass Tuning: 5-string standard tuning (BEADG) Maverick, I'd like to thank you very much and the others for contributing with the thread while I was away. If you don't mind, I can review all your tabs and add the rest of the instruments together with Seth_Slax (yes, he's still around and again wrote the drums for this one, truly a master of drums). If you authorize, just lemme know ok? Then I can start working on them. I can't guarantee this one is 100% accurate, but I think it is very close and I hope you like it. See you next time and take care!
Hello everyone. Seth and I are back again, this time with Howling Moon II, for your listening pleasure. There might be some mistakes from my part in the solo, but I guarantee the tab is 90% accurate or so. Also, Seth did a godlike work with the drums, so I thank him once again for collaborating with me. Guitar Tuning: 7-string (BEADGBE) or 6-string (BEADGB) for the rhythm guitar. Lead/solo guitar could be in E Standard Tuning. Bass: 5-string (BEADG) or 4-string (BEAD) Most of the keyboards were written this time around. I'm sleepy right now, so sorry for any misspellings. Enjoy and 'till next time!
Hello guys! Seth and I are back now with the tab for SIX-HEROES, so we hope this compensates for the long wait =P There are more tabs coming in the next weeks and a few surprises for you, so check back once in a week ok? Guitar and Bass Tuning: Eb (half step down the standard one). There are some keyboards and all the drums (cortesy of Seth, of course). Enjoy! Six Heroes v1.0.zip Thank you TTNH03! Request taken. Added to the queue. Do not hesitate. I will do all songs eventually It just takes time and sometimes I may not be able too. Also, Seth may be busy to because he is the one who writes the drums for the tabs. Will, it is not exactly a II version from BBCP, but I think Six Heroes will do for now? Sorry Minato, we are back for a while now, I hope I can keep up and write more tabs. Take care everyone and keep rockin! Guilty Gear Xrd is around the corner!
Reuploading some old tabs I forgot, but now containing Seth_Slax drum work. Just reviewed Under Heaven Destruction. I've used the Dropped D Tuning for all guitars, and a D-Tuned 4-string bass okay? I wrote some of the keyboards and the solo. The tapping part, I did not use any effect or delay to emulate the original song, please, may I ask you guys to figure it out? I did a hybrid version, mixing elements of the AOU trailer version and the final song! I hope you still like it! I will update the first page now, so you won't have to worry about searching for the files anymore Till next time and keep rockin'! Added to the queue Added as well XD No donations required I'll do all of them eventually.
Hello guys. Long time no see. I hope you are doing well. Continuing the discussion, I think Terumi/Hazama is only "afraid" of Saya only because she is his new observer, which is hinted by the end of Continuum Shift when he deactivated Takamagahara, his current observer by then. But what I'm really intrigued is about that image of Azrael and Kagura. The aura behind Azrael is strikingly similar to the Black Beast, so here's my two cents about him: . He is either a homunculus or a human infused with the beast genes, in an experiment-gone-wrong by Sector Seven. . After the experiment, his mind was shattered and he became obsessed with combat; . It would explain his nature of not differentiating friend from foe due to the overuse of his "power" (this applies to Ragna, as seen during his bad ending in CS); . His name is a reference to an angel of death... Ragna is the god of death, so yeah... this could be a hint that their nature is similar; . Azrael did not attain the Soul Eater properties, but maybe Sector 7's objective was to create and mass produce powerful soldiers to use against the NOL... . Enchant Dragunov acts as a limiter and I bet it is magic, in the BB world magic > armagus.. This may be a huge stretch, but might be worthy of a discussion.... PS: I will be back with new BB and GG tabs as soon as I enter vacations, a couple months from now.
Hahahahahaha, actually. You and everyone from Dustloop are in for a treat, because I just did... Azrael's Theme!!!! I started to work a few weeks ago, but I was just able to put the final touches today. Seth_Slax wrote all the drums again (he's the true beast here gentlemen \m/). When I first listened to this theme, I felt like I needed a new challenge to overcome and create a cool tab for it Hope you like it. Tuning: Dropped C (Rhythm Guitar), E Standard (Solo/Lead Guitar), C Tuning (4-string bass). Instruments: Keyboards, Guitars, Bass (4-string), Drums I'm glad you like them. Some of them takes a lot of effort to figure out the correct notes. Not yet. You can always ask to include in the queue if you wish for a tab related do GG or BB. That's it for now guys! A kind reminder: if anyone chooses to download the tabs and throw in remixes somewhere, make sure to give credit to me and Seth ok? I appreciate. Merry Xmas everybody. See you soon!
Phew. Finally got some time to reply each message. One at a time. I'll try to be quick ok? Thanks Djentleman. Ride On Time will be added for sure. I'll count your vote Rest assured. I'll carry on. Sure. I'll add this one. Man, it is so cool to watch. Thank you for this. You don't offend my ears at all. For a first time, it is great. Please, keep up. Calm down, I'll do it someday. There will be many others from now on. Just be patient I don't have much knowledge to help you Thank you Ryter. Sure, I'll add them to the list. I'm glad to read this. I like this. Don't worry about the solo, the rhythm is just great. You achieved a great performance using only a 6-string. I hope you record more covers as time passes on. Please, do not give up playing. It takes a lot of time and effort (John Petrucci, of Dream Theater, practices a half dozen hours per day 0_0, for example). I'll honor your request. And about Hard Corps Uprising, I will have a listen to know better. Happy drumming I really loved your rendition of the lead guitar. Hope to see more of your videos soon! Hahah. I'm back Minato. Sorry for about the absence. I'll try not to vanish from the face of the earth (laughs). Jokes aside, I'm glad you like the tabs. Endless Despair will be done eventually. I'll carry on. Rest assured. Your messages are the things that keep me going with the thread. Cheers guys! I'll begin working on the next tab (????) shortly.
Hi all. I want to thank you for the patience and for not letting the thread die. Also, thank you all for the compliments and support. I'm truly happy. A lot of stuff has happened this year and I had to be absent to handle everything. Unfortunately, I had to stop my tabbing work because I'm not having free time as before, but I've managed to pull a new tab out just for you . First things first. I bring to you my newest work - Imperial Code - complete, with drums, guitar, solos and some of the keyboards. Tuning is Eb for all instruments. I'm using a 7-string line for the keyboards in order to reach the lower notes. Seth contacted me yesterday to ask how I was doing and luckly I just got back to my tab work last friday in order to add some keyboards (the keyboards are the most difficult lines for me to figure out because of mixing reasons). Well, I can say that I'm back (again, LOL) and I'll continue my work with the tabs. Some of you might wonder: "Why are you not following the queue this time"? I think I'll change the way I handle the queue. I'll leave the most complex tabs for last. I don't know if this is a bad thing or not, but this way I may be more consistent in creating the tabs and uploading then for you. I mean, I could deliver more tabs in a shorter time frame. Also, this method could add a little surprise and twist, because you don't know what's next. Maybe this is cool for some and not so cool for others. I'm sorry about this. I hope you understand. I will still update the queue by order of requests, so you may check if your song was added already. I'll answer every message (including private messages) during the week, but then again, I want to thank you all from Dustloop and the ones keeping this thread alive. I was happy to see the cover videos and all the positive feedback. And I want to say special thanks to Seth, he is doing an impressive job with the drum and percussion lines. Till the next time (or next tab?). And of course... Keep rockin'! PS: Give me a little time and I'll keep things in order in this thread.


Iman Khamis is Technical Services Librarian at NU-Q Library. Before joining NU-Q Library she was working at the Bibliotheca Alexandrina in Alexandria, Egypt. Over the last ten years she held several positions from Arabic Cataloger to Senior Technical Services Librarian at Alexandria Library, which includes creating metadata for library different resources, providing reference, resources selection, database management, and training staff.
She has a BA in biological and geological sciences, and MA in library & information science from the University College London, Qatar. Her research interests include bioinformatics, information management in medical field, information use in different cultures, RDA, Library Information Systems and Web 2.0 in libraries.


The Ernest Hemingway H4618 Eyeglasses by Ernest Hemingway has many superb features. The length of the temple pieces are 140 millimeters. The width of the bridge of this frame is 17 millimeters. The eyesize of this item is 46 millimeters. The dappled amber tones of tortoiseshell have timeless class. Item ranges in price between $60 and $100. A full plastic frame that may contain some metal for structual integrity. One of our most popular items. This item is eligible for prescription lens installation and has a high enough vertical width for your bi-focal or progressive lens. Black is the most common color seen in the dark. Full Rim glasses cover the lens on all sides. This item is eligible for prescription lens installation.
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text:
Is this really Nokia's 'masterpiece'?
By James Rogerson 2013-11-26T13:22:00.329Z Mobile phones
2. Interface
3. Contacts and calling
7. Lumia 925 vs Lumia 920 - which camera is best?
10. Battery life and connectivity
11. Maps and apps
12. Official gallery
13. Verdict
Getting down with the Nokia Lumia 925
The Nokia Lumia 925 comes with HERE Maps, which is Nokia's own mapping solution.
It's a pretty good offering, with options to get directions, view traffic data, public transport information or a satellite view of an area.
It will also list nearby places, and you can download maps for offline use, which is very handy when you're travelling. It never had any problem locking on to our location either.
Alongside it there's also HERE Drive, which is a free sat nav app, and is similarly useful.
Like the maps app it can download maps for offline use, plus it can also display maps in either a 2D or 3D view.
Once you set a destination and start driving it will give you both spoken and written instructions, as well as displaying an estimate of your current speed and even an estimated arrival time.
You can change between metric and imperial units, and there are useful extra features such as the ability to show petrol stations and car parks on the map or set an alert to go off if you exceed a certain speed. All in all, for a free offering it's a hugely accomplished app.
Completing the triumvirate of HERE apps, Nokia has also included HERE City Lens on the Lumia 925, which uses your phone's camera and compass to overlay the outside world with markers for places of interest and lead you to them, be they restaurants, museums or shops.
Nokia loves this app, but we're less impressed. We don't need to see where it is, just a list of what's around - the augmented reality element seems more gimmick than useful. It's no better than Google Maps at giving local treasures, so we'd like to see more from the app in the future for us to call it a boon.
The Nokia Lumia 925 doesn't fare quite so well with other, non-mapping, apps. Most fall into the category of the expected - such as a calendar, a calculator and an alarm clock, all of which are perfectly functional but don't do anything out of the ordinary, or the useless - such as Angry Birds Roost, which is basically just Angry Birds news, ringtones and wallpapers.
Similarly useless is World of Red Bull, which presents news and videos about athletes and sporting events that are sponsored or hosted by Red Bull.
Extreme sports enthusiasts may get some enjoyment out of it but we doubt many people will ever even open it. Plus it doesn't include Sebastian Vettel from Red Bull Racing in F1. What? Why?
It's not a total app write-off though with the Lumia 925, because you also get Data Sense, which is a handy tool for keeping track of how much data you use and ensuring that you don't go over your monthly limit.
There's also Microsoft Office and OneNote, the mobile versions of which while not quite as full featured as their desktop counterparts are still as much as you could ever hope to get from a phone app.
Since many businesses use the desktop versions, having the same software on your phone could come in handy for working on the move.
The biggest problem with apps on the Nokia Lumia 925 is the app store itself, since it's just not all that well stocked.
If we hadn't been spoiled by Apple's App Store and Google Play we might not have minded, but we have and we do.
A lot of major apps are covered, for example you can get YouTube and Facebook, but there's nowhere near the number or variety of apps that we'd like to see.
As we explained in the Introduction page, the way apps are organised on the Nokia Lumia 925 is impressive, though.
Apps are represented by Windows Phone 8 tiles, many of which display live information or pictures, such as the number of unread emails in your inbox or a slideshow of your contacts' photos.
Tap on a tile to launch the app or long-press it to move, resize or remove it.
Current page: Maps and apps
Prev Page Battery life and connectivity Next Page Official gallery


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March update from the director: Sea Grant's 50th anniversary
by Mark Risse, director of UGA Marine Extension and Georgia Sea Grant
Earlier this year, director Mark Risse attended "Coastal Day at the Capitol" to dialogue with policymakers about current coastal issues and Georgia Sea Grant's efforts to address them.
Let's start the celebration. In 1966, President Lyndon Johnson signed The National Sea Grant College and Program Act, establishing the Sea Grant Program. Today, the National Sea Grant College program is a network of 33 programs based at top universities in every coastal and Great Lakes state, Puerto Rico and Guam.
As the National Sea Grant College Program celebrates its 50th anniversary this year, it is important to take stock in what has been accomplished with this long-term partnership between the National Oceanic and Atmospheric Administration and the various states bordering significant water bodies around the country. Throughout the nation, these partnerships have yielded significant advances in knowledge, products and services that have helped coastal communities and constituents.
The Georgia Sea Grant College program is no exception. Through its partnerships with researchers at the University of Georgia and all other higher education institutions in Georgia, its engagement with coastal stakeholders and its emphasis on extension and education, Georgia Sea Grant has had profound impacts on the economic and ecological well-being of our coastal communities.
From transforming Georgia's shrimping industry with the use of Turtle Exclusion Devices that reduce by-catch to working with local governments in coastal communities to respond to sea level rise and nuisance flooding, Georgia Sea Grant has continued to make a difference.
We have trained seafood business employees in proper seafood handling and storage and protected consumers in the process. We are educating youth and preparing a responsible and skilled workforce while also engaging new scholars and seasoned researchers to help coastal leaders and managers solve critical issues.
Perhaps most importantly, we engage with our constituents. We work with them to identify the critical issues, investigate whether existing resources or solutions exist within our higher education or national networks and sponsor research to develop new solutions.
In the 36 years since its inception, the Georgia Sea Grant College Program continues to make a difference in the lives of Georgians by serving the state of Georgia and the nation. Over the coming year, as we celebrate the 50th anniversary of the National Sea Grant program, we hope to look back at some of our significant accomplishments as well as look forward to those yet to come.


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Setting Aside a Prenuptial Agreement
Published by Amir Ghorbani on August 5, 2022 August 5, 2022
I am often asked about the possibility of setting aside a prenuptial agreement. Some clients want to know whether a prenuptial agreement would protect them if their relationship broke down. Other clients have a prenuptial agreement that they are unhappy with and want it set aside.
In this article, I will explain how prenuptial agreements are set aside. I will also write about a 2016 Supreme Court of British Columbia case where the prenuptial agreement was set aside as an example.
Family Law Act – Setting Aside a Family Agreement Concerning Property Division
Section 93 of the Family Law Act provides judges with the power to set aside a family agreement. However, the criteria in section 93 must be met before a family agreement is set aside:
93 (1)This section applies if spouses have a written agreement respecting division of property and debt, with the signature of each spouse witnessed by at least one other person.
(2) For the purposes of subsection (1), the same person may witness each signature.
(3) On application by a spouse, the Supreme Court may set aside or replace with an order made under this Part all or part of an agreement described in subsection (1) only if satisfied that one or more of the following circumstances existed when the parties entered into the agreement:
(a) a spouse failed to disclose significant property or debts, or other information relevant to the negotiation of the agreement;
(b) a spouse took improper advantage of the other spouse's vulnerability, including the other spouse's ignorance, need or distress;
(c) a spouse did not understand the nature or consequences of the agreement;
(d) other circumstances that would, under the common law, cause all or part of a contract to be voidable.
(4) The Supreme Court may decline to act under subsection (3) if, on consideration of all of the evidence, the Supreme Court would not replace the agreement with an order that is substantially different from the terms set out in the agreement.
(5) Despite subsection (3), the Supreme Court may set aside or replace with an order made under this Part all or part of an agreement if satisfied that none of the circumstances described in that subsection existed when the parties entered into the agreement but that the agreement is significantly unfair on consideration of the following:
(a)the length of time that has passed since the agreement was made;
(b)the intention of the spouses, in making the agreement, to achieve certainty;
(c)the degree to which the spouses relied on the terms of the agreement.
(6) Despite subsection (1), the Supreme Court may apply this section to an unwitnessed written agreement if the court is satisfied it would be appropriate to do so in all of the circumstances.
The Family Law Act became law on March 18, 2013. Prior to that date, the Family Relations Act governed family law in the province. Applications to set aside agreements entered into before March 18, 2013 are decided under the Family Relations Act. Section 65 of the Family Relations Act has an effect similar to section 93 of the Family Law Act:
65 (1) If the provisions for division of property between spouses under section 56, Part 6 or their marriage agreement, as the case may be, would be unfair having regard to
(a) the duration of the marriage,
(b) the duration of the period during which the spouses have lived separate and apart,
(c) the date when property was acquired or disposed of,
(d) the extent to which property was acquired by one spouse through inheritance or gift,
(e) the needs of each spouse to become or remain economically independent and self sufficient, or
(f) any other circumstances relating to the acquisition, preservation, maintenance, improvement or use of property or the capacity or liabilities of a spouse,
the Supreme Court, on application, may order that the property covered by section 56, Part 6 or the marriage agreement, as the case may be, be divided into shares fixed by the court.
(2) Additionally or alternatively, the court may order that other property not covered by section 56, Part 6 or the marriage agreement, as the case may be, of one spouse be vested in the other spouse.
(3) If the division of a pension under Part 6 would be unfair having regard to the exclusion from division of the portion of a pension earned before the marriage and it is inconvenient to adjust the division by reapportioning entitlement to another asset, the Supreme Court, on application, may divide the excluded portion between the spouse and member into shares fixed by the court.
Therefore, we can see some of the factors that can convince a court to set aside a prenuptial agreement. These factors include:
Failure to disclose assets, property, or debt to a partner when the agreement was signed.
Taking advantage of a partner's financial or other vulnerability, ignorance, and distress.
One of the parties not understanding the legal consequences of the agreement when they sign it.
If the agreement is voidable under the rules of common law, such as:
The agreement is unconscionable.
The agreement was entered into under undue influence.
One of the parties did not have the legal capacity to enter into the contract at the time the contract was made.
If the prenuptial agreement was significantly unfair based on:
The length of time since it was signed.
The intentions of the spouses to achieve certainty when they signed the contract.
The degree to which the spouses relied on the terms of the prenuptial agreement.
H.S.S. v. S.H.D., 2016 BCSC 1300 [HSS]
HSS was a family law case between Mrs. D, a wealthy heiress whose family had fallen on hard times, and Mr. S, a self-made lawyer who had amassed a considerable fortune during his career. At the time of Mr. S and Mrs. D's marriage, the two signed a prenuptial agreement to protect Mrs. D's property. However, by the time of the trial, Mrs. D's family had lost a considerable part of their fortune. Although Mrs. D was still a wealthy woman by all accounts, having received millions of dollars in gifts and inheritances from her family.
Mr. S was not a wealthy person at the time of his marriage, however, by the time of trial in 2016, he had approximately $20 million dollars in personal wealth, more than twice as much as Mrs. D's assets.
The parties had two adult children at the time of the trial. The older daughter, N, had significant learning difficulties and allergies while she was young. As a result of N's health problems, Mrs. D had to leave her lucrative career in Human Resources to take care for N while Mr. S continued to work. Therefore, Mrs. D did not have an income when the parties separated in 2003, and she had not returned to her lucrative career by 2016.
The court decided to set aside the prenuptial agreement because Mrs. D and Mr. S had not considered the possibility of having a child with health difficulties at the time of signing the prenuptial agreement. Therefore, Mrs. D's lack of an income in 2016 and her lack of self-sufficiency was an unexpected consequence of the prenuptial agreement. This unexpected consequence justified setting the prenuptial agreement aside.
Lawyer's Role in Protecting Your Rights
As you can see, there are many reasons why a prenuptial agreement may be set aside. Therefore, it is imperative that you draft and sign your prenuptial agreement with the help of an experienced lawyer. The lawyer can draft a thorough agreement to reduce the chances of it becoming unfair in the future. Furthermore, the lawyer will ensure that the signing and execution of the agreement will be done under fair circumstances so that the agreement is not voidable.
Without the assistance of a lawyer in the drafting and execution of a prenuptial agreement, the chances of a challenge to the prenuptial agreement increase. Additionally, if the prenuptial agreement were to be challenged, it would be more likely that a court would set it aside.
If you are considering moving in with your partner or getting married, contact Amir Ghorbani about getting a prenuptial agreement to protect yourself and your property.
Categories: Family LawFamily Law AgreementsPrenuptial Agreements
Tags: prenupprenuptial agreementunfair prenuptial agreement
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Transform the member experience, increase operational efficiency, and generate more revenue through a suite of association solutions from Community Brands.
The association software suite helps professional, philanthropic and trade associations increase revenue, improve efficiency and engage members. With easy-to-use solutions, executive directors, membership managers, accountants, event planners, and foundation leaders can all work together to help their organizations achieve success.


For people who suffer from back pains, getting a recliner would be ideal. There are several companies in the market that sell recliners. So, what should you look out for when buying recliner? If you are having a challenge choosing which company you should get the recliners from, the tips below can make it much easier.
Contact your friends and family members and ask them if they know a good company that sells recliners. If the recliners are meeting their needs, they will recommend the company to you.
Variety is another factor you should consider when choosing a company to buy the recliners from. When it comes to recliners, people have different needs. A good company should have various types of recliners to suit the needs of their various clients. You can call the company and inquire, if they have the recliner that you are looking for.
Quality is another factor you should consider when buying recliners. A reputable company will ensure all the recliners that they are selling are of good quality. Recliners made from good material will serve you for a long duration of time and they will still be in good condition.
Does the company have experience in selling recliners? The longer the duration of time the company has been in this field, the better. The company has diverse knowledge in recliners that they have gained over the years.
How much is the company selling the recliner? The more features the recliner has, the higher the price will be. It is important you go through the website of different companies, compare the prices then choose one that is within your price range.
Before you buy the recliner from the company, ask them if they will issue you with a warranty. If the company does not issue a warranty, its best you look for another alternative.
Location is another factor you should consider when choosing a company to buy the recliners from. You can easily walk into the company and check the different recliners they have in stock. Use the internet to find companies that sell recliners that are based in your area.
It is advisable you check the reviews that have been done on the company you are planning to buy the recliners from. By reading the reviews that have been done on the company, you will know if the company is fit to get the recliners from or not. When reading the reviews, check from trusted sources online. Get the recliners from a company that has the best reviews online.
Get the recliners from a company that has staff who are friendly and polite.


MeetScoresOnline is a free online service for publishing and viewing gymnastic scores. You can publish both live and past scores to our site. MeetScoresOnline is the leading online resource for gymnastic scores and stats.
If you are a parent or athlete, MeetScoresOnline is the perfect place to get noticed with an MSO Athlete Profile.
Need to reach us? No problem! We are here for you. You can send us an email, send us a text, message, Facebook message us, Twitter, G+, etc. Follow our social links below if you wish to contact us through social networking. Reach us by phone, email or text.
If you are looking to publish scores, either live or past scores, click New Event Registration below. Also, you can distribute all of your event material here, simply publish all of your event information to MeetScoresOnline from the event registration console. Everything from event flyers, meet information, maps, directions, registration forms, and more.. publish everything to MSO under your event.
Receive live score updates to your mobile phone. Available for live publishing events only.
If you are having technical difficulties with your scoring software please contact the vendor directly.
An MSO Athlete Profile is the best way to highlight skills and accomplishments for the athlete. Get recognized on MSO, show off your skill and competition videos. With an Athlete Profile you can link competition videos to your scores, upload skill and training videos, write your biography, list your major accomplishments and more.
In order to publish scores first you must register your event. You can register your event - here -.
Once you have registered and activated your event then you are ready to go. Simply make note of your MeetID and Password that we generated and follow along with the instructions under Software Vendor Support. Publishing scores to MeetScoresOnline is built into these applications. Most people publish scores live at the event, but you can also publish scores after each rotation, session, day, or the weekend (whatever suits your needs).
Navigating the calendar is easy. Drop down by state and season to quickly find future and past events.
Need help with your AGymnast profile? What is an AGymnast profile? An AGymnast profile is an MSO Profile with your custom AGymnast Address, so it would be something like AGymnast.com/YourName This is your custom gymnastics website on the internet!
Live scoreboards are courtside displays that rotate all-around scores and team scores live while your meet is in progress.
Need to import gymnastic scores? Import Beyond the Scores CSV or scores from Excel. For complete instructions click on Full Instructions.
MSO is on Google+, Twitter, and Facebook. We hope you will follow, like, share, or tweet along with us. We also have a blog on our site you can keep up with.
Are you a writer, a photographer, videographer, or other enthusiast of the sport? Then MSO is your sounding board! Reach out to us and let us know how you would like to contribute. We are willing to give full credit to you for your outstanding work and showcase your information on our website and social sites.


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"Being the Ricardos" Official Trailer Reveals Aaron Sorkin's Lucy & Desi Drama
The official trailer for writer/director Aaron Sorkin's Being the Ricardos is here, giving us a longer glimpse at Nicole Kidman and Javier Bardem as the legendary Hollywood power couple Lucille Ball and Desi Arnaz. Sorkin's film will follow Lucy and Desi during a particularly tumultuous week of production on their groundbreaking, massively popular show I Love Lucy. Lucy finds herself at the center of a political smear campaign and the couple's romantic and professional life comes under unbearable scrutiny—all while they need to put on a show.
Sorkin knows his way around a story set behind the scenes of a television production. His shows Studio 60 on the Sunset Strip and The Newsroom were both set on set, on a Saturday Night Live-like sketch show in the former, and on a CNN-like news program in the latter. In Being the Ricardos, Sorkin has set his sights on one of the most transformative talents of the 20th century in Lucille Ball (Desi Arnaz was no slouch, either), and his ear for dialogue seems tailor-made for the legendary comedienne. Being the Ricardos will take us from a Monday table read through the live show on Friday and behind the closed doors of one of the most transformative television shows ever made. It will also take inside one of Hollywood's most fruitful, fitful relationships.
Joining Kidman and Bardem are a deep bench of great performers, including J.K. Simmons, Jake Lacy, Nina Arianda, Alia Shawkat, Linda Lavin, Clark Gregg, and Tony Hale. Being the Ricardos will open in theaters on December 10, and then onto Amazon Prime Video on December 21.
Check out the official trailer here:
For more on Amazon Prime Video, check out these stories:
"Being The Ricardos" Trailer Reveals Nicole Kidman & Javier Bardem as Lucille Ball & Desi Arnaz
Director Kay Cannon on Bringing the Modern & the Funny to "Cinderella"
Final "Annette" Trailer Sheds Fresh Light on Cannes Crowd Pleaser
Amazon Reveals First Image From "The Lord of the Rings" Series
"Annette" Trailer Reveals Adam Driver & Marion Cotillard's Mysterious Musical
Featured image: "Being the Ricardos" art. Courtesy Amazon.
TAGSAmazon Studios Being The Ricardos
"The Lord of the Rings: The Rings of Power" Early Reactions Call it a Beautiful, Joyous Return to Middle-earth
"The Lord of the Rings: The Rings of Power" Official Trailer Announces TV's Most Epic Production


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TRIUMF's Director Nigel S. Lockyer Tapped to Head Major U.S. Particle-Physics Laboratory
TRIUMF (Canada's National Laboratory of Particle and Nuclear Physics)
Jun 20, 2013, 13:10 ET
VANCOUVER, June 20, 2013 /CNW/ - In his capacity as Chairman of the Board of Directors of Fermi Research Alliance, LLC, University of Chicago President Robert J. Zimmer today announced that TRIUMF's director Nigel S. Lockyer has been selected to become the next director of the U.S. Department of Energy's Fermi National Accelerator Laboratory, located outside Chicago. Lockyer is expected to complete his work at TRIUMF this summer and begin at Fermilab in the autumn.
Paul Young, Chair of TRIUMF's Board of Management and Vice President of Research and Innovation at the University of Toronto said, "Nigel was selected from a truly outstanding set of international candidates for this challenging and important position. Although it will be a short-term loss, this development is a clear recognition of Nigel's vision and passion for science and the international leadership taken by TRIUMF and Canada in subatomic physics. On behalf of the entire TRIUMF Board, we wish Nigel, TRIUMF, and Fermilab every success in the future."
Lockyer set TRIUMF upon a new course when he arrived six years ago, focusing the team on "Advancing isotopes for science and medicine." Based on TRIUMF's existing infrastructure and talent, this initiative ranged from expanding the nuclear-medicine program so that it is now playing a leading role in resolving the medical-isotope crisis to the formulation and funding of a new flagship facility called ARIEL that will double TRIUMF's capabilities for producing exotic isotopes used in science and for developing tomorrow's medical isotopes. At the heart of ARIEL is a next-generation electron accelerator using modern superconducting radio-frequency technology.
Commenting on Nigel's leadership of TRIUMF, Paul Young added, "One look at TRIUMF's current trajectory and you can see that this is a man of great ambition and talent. Working with the Board and a great team at the lab, he propelled TRIUMF to new heights. We have all been fortunate at TRIUMF to have Nigel as a colleague and leader."
Reflecting on his time at TRIUMF and the upcoming transition to Fermilab, Nigel Lockyer said, "Knowing that TRIUMF is in good hands with a superb leadership team and seeing its growing string of accomplishments has helped make this decision a tiny bit easier. The laboratory's future is secure and TRIUMF knows exactly what it is doing. I am proud to have contributed to TRIUMF's successes and it is my hope to ignite the same energy and enthusiasm in the U.S. by heading the team at Fermilab." He added, "I also expect to foster a new level of partnership between the U.S. and Canada in these key areas of science and technology."
"Nigel has had a profound impact on TRIUMF," said David B. MacFarlane, chair of the National Research Council's Advisory Committee on TRIUMF and Associate Laboratory Director at the U.S. SLAC National Accelerator Laboratory. "He articulated an ambitious new vision for the laboratory and energetically set it upon a path toward an exciting world-class program in rare-isotope beams and subatomic-physics research. When ARIEL comes online, the lab will be fulfilling the vision that Nigel and his team boldly initiated." David MacFarlane added, "The TRIUMF community will certainly miss his warmth, his insatiable scientific curiosity, his creativity, and his faith in the laboratory and its entire staff. However, I fully expect these same characteristics will serve Nigel well in his new leadership role as Fermilab director."
As per standard practice, the TRIUMF Board of Management will announce plans and timelines for the international search process and interim leadership within the next few weeks.
For more about Fermilab and Lockyer's appointment, please see URL http://www.fnal.gov/pub/presspass/press_releases/2013/Lockyer-Named-Fermilab-Director-20130620.html.
About TRIUMF
TRIUMF is Canada's national laboratory for particle and nuclear physics. Together with its partner AAPS, Inc., TRIUMF also seeks to commercialize its technologies for the benefit of all Canadians. Located on the south campus of the University of British Columbia, TRIUMF receives operating support from the Government of Canada through a contribution agreement via National Research Council Canada; the Government of British Columbia provides capital for new buildings. TRIUMF is owned and operated as a joint venture by a consortium of the following Canadian universities: University of Alberta, University of British Columbia, University of Calgary, Carleton University, University of Guelph, University of Manitoba, McGill University, McMaster University, Université de Montréal, University of Northern British Columbia, Queen's University, University of Regina, Saint Mary's University, Simon Fraser University, University of Toronto, University of Victoria, University of Winnipeg, and York University. For more information, please visit us at http://www.triumf.ca.
SOURCE: TRIUMF (Canada's National Laboratory of Particle and Nuclear Physics)
Tim Meyer
Head, Strategic Planning & Communication
Tel: 604.222.7674 | Cell: 604.235.1925
Jim Hanlon
Secretary to the TRIUMF Board of Management
Head, Business & Administration Division


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Global indexing giant MSCI has rolled out a new factor investment system spanning multiple asset classes.
The MSCI Multi-Asset Class Factor Model "helps investors analyze key portfolio exposures across asset classes through an integrated and consistent framework", the group said in a statement.
Factor investing, also known as 'smart beta', has ballooned in recent years with fund managers and index providers scrambling to meet demand. Last year a survey by another index behemoth, FTSE Russell, found about half of large asset-owners globally had invested in smart beta strategies with a further 25 per cent intending to allocate to factor funds in the near term.
For example, the NZ Superannuation Fund, which has already plonked over $1 billion in factor strategies, is poised to up its allocation to smart beta investments, chief executive, Matt Whineray, said last year.
While smart beta has been traditionally limited to equities, MSCI says its just-released model will enable investors to identify, manage and combine factors across a wide range of asset classes including fixed income, commodities, and currencies.
MSCI says the growth of multi-strategy, outcomes-oriented and balanced fund styles has seen more investors exposed to "complex, dynamic" risk and return drivers.
communicate multi-asset class portfolio investments more easily.
Peter Zangari, MSCI global head of research and product development, said in the release: "The growth of factor investing has transformed the way investors view their portfolios, underscoring the importance of factor awareness in active portfolio management.


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On Tuesday night at the scenic LeFrak Center in Prospect Park, roughly 600 people came together for the 2015 Cancer Center Benefit, organized by the Brooklyn-based Maimonides Cancer Center, to celebrate the facility's 10th anniversary. The event was hosted by Patrick Borgen, M.D., director of the Maimonides Breast Center, and Erminia Rivera, co-chair of the Maimonides Cancer Center Advisory Board.
Rivera opened the event with a story of her own.
Three honors were given out at the event. The Brooklyn Nets were given the Champions of Brooklyn Award for their donations to the Cancer Center, with Brett Yormark, CEO of the Brooklyn Nets, and Barclays Center, representing the team.
The Community Leadership Award was given to Hildy J. Simmons, a Brooklyn-based independent consultant who has been involved with the philanthropic community for decades.
She was previously head of the Global Foundations Group at JP Morgan and has also served as the program director of the Norman Foundation.
Dr. Samuel Kopel, who has served as chief medical officer at Maimonides since 1995, was honored with the Founder's Award. He has been practicing for 44 years and specializes in hematology, which includes the study and treatment of diseases such as leukemia and lymphoma.


Engaging with citizens results in service improvements, enhanced efficiency and greater public goodwill, a number of forward-looking Indian public service providers are discovering.
A new publication, Engaging with Citizens to Improve Services, examines 10 initiatives designed to improve service, extend coverage and make public service providers more accountable to the public.
During the 1980s Bangalore's population grew rapidly, from 2.9 million in 1981 to 4.1 million in 1993. The city's emergence as a global software hub created a sudden expansion in the demand for municipal services, such as water and sanitation. As a result, there was a considerable lag between the demand and supply for services in Bangalore.
Concerned by the deteriorating situation, a group of residents formed the Public Affairs Centre, to create a citizen monitoring program -- Citizen Report Cards (CRC). The report cards survey citizens about the state of public services and developmental programs.
In the first survey, respondents were asked to assess eight of the city's key public agencies on a scale of 1 to 7. They were also asked what direct and indirect costs they bore as a result of poor service, how courteous the agency had been and whether it had been necessary to make illegal payments. Less than 25 percent of respondents expressed satisfaction with any of these agencies.
While CRCs do not trigger service improvements by themselves, they are a tool to gauge public feeling and convert it into intervention. The impact of the reports vary across situations, depending on the willingness of key government agencies to act on the findings.
However, a number of common gains and outcomes can be seen from the CRC experience. For example, in Bangalore the report card was used to pressure improvements from local service agencies by mobilizing a coalition of civil society organizations to demand better service.
The Public Affairs Centre calls the reports a move from 'shouting to counting' and from 'protest to proposal'.
In Mumbai, India's largest city, which is predicted to grow to the world's most populated city by 2015 with 28.5 million people, half of the population consists of the urban poor. Mumbai's island geography, its limited public railway system and its rapid population growth have resulted in a severe shortage of urban public services, housing and infrastructure.
In Mumbai, PRAJA, a civil society organization, helped the Mumbai Municipal Corporation set up an Online Complaint Monitoring System. This not only enables Mumbai citizens to register service-related complaints via telephone, personal visits, letter/fax and the Internet, but also to access online information regarding redressal status – without having to call or visit a corporation office.
The strong public demand for better governance in Mumbai has resulted in the emergence of over 2,000 active civil society groups demanding improved public services and quality of life.
All of the case studies underline the importance of effective consumer education in enabling users to hold their providers accountable. The process also triggers a gradual shift toward service outcomes that reflect customer satisfaction, rather than expenditure and construction targets as is currently the norm.
The case studies make it clear that significant service and accountability gains from formally engaging citizens at all points of the service delivery chain. Better services and delivery mechanisms, which are more efficient, affordable and reach more of the population, result when policy makers understand provider performance and citizens' needs.
While the above examples show what can be achieved for efficient, effective service provision through citizen engagement, a comprehensive application of mechanisms of citizen participation are yet to be seen in any single case.