text:
Daeun Yi
Gushing North Korean broadcaster Ri Chun Hee hails Trump-Kim summit
SEOUL North Korean television presenter Ri Chun Hee has for years announced the biggest news in her own effusive style, and this week she returned to the airwaves to herald Kim Jong Un's historic meeting with U.S. President Donald Trump.
SEOUL, June 14 North Korean television presenter Ri Chun Hee has for years announced the biggest news in her own effusive style, and this week she returned to the airwaves to herald Kim Jong Un's historic meeting with U.S. President Donald Trump.
Rush to replay leaders' handshake revives appeal of Korean movie set
NAMYANGJU, South Korea When a smiling North Korean leader Kim Jong Un shook hands with South Korean President Moon Jae-in on the border of their countries during a summit last month, images of the historic moment grabbed the world's attention. | Video
Exclusive: U.S. Gulf maritime proposal not military coalition against Iran - Pentagon official
The United States is not aiming to set up a military coalition against Iran with its new security initiative in the Gulf, but simply "shining a flashlight" in the region to deter attacks on commercial ships, a top Pentagon official told Reuters.
Mexico president calls 'El Chapo' sentence inhumane, vows better society
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Don't 'take the bait': Squad Dems decry Trump attacks


Kovalev Ivan Georgievich – neurologist, a graduate student, Research Institute named after VV Zakusov.
Stepanishhev Igor' L'vovich – MD, neurologist, head of psychoneurology Children's City Clinical Hospital named after ZA Bashlyaeva.
Address: ul. Geroev Panfilovcev,Moscow,Russia, 125373.
Address: ul. Barrikadnaja, d. 2/1, Moscow, Russia, 125993.
Voronina Tat'jana Aleksandrovna – MD, Professor, Honored Scientist, Head of Laboratory of Pharmacology Psychopharmacology.
Address: ul. Baltijskaja, 8, Moscow, Russia, 125315.
1. Gusev E.I., Gekht A.B., Khauzer V.A., Mil'chakova L.E., Churilin Yu.Yu. Epidemiology of epilepsy in Russia [Epidemiologiya epilepsii v Rossii (in Russian)]. 2011; 77-84.
2. Mukhin K.Yu., Petrukhin A.S., Mironov M.B. Epileptic syndromes. Diagnosis and Therapy. Reference Guide for physicians [Epilepticheskie sindromy. Diagnostika i terapiya. Spravochnoe rukovodstvo dlya vrachei (in Russian)]. Moscow. 2008.
3. Petrukhin A.S., Mukhin K.Yu., Blagosklonova N.K., Alikhanov A.A. Epileptology childhood [Epileptologiya detskogo vozrasta (in Russian)]. Moscow. 2000; 623 s.
4. Avoli M., Gloor P., Kostopoulos G., Gotman J. An analysis of penicillin-induced generalized spike-and-wave discharges using simultaneous recording of cortical and thalamic single units. J Neurophysiol. 1983; 50: 819-37.
5. Bauer G., Bauer R., Dobesberger J., Unterberger I., Ortler M., Ndayisaba J.P., Trinka E. Departments of Neurology, Medical University Innsbruck, Innsbruck, Austria. J Clin Neurophysiol. 2008 Oct; 25 (5): 250-4 Broad sharp waves-an underrecognized EEG pattern in patients with epileptic seizures.
6. Bancaud J., Talairach J., Geier S., Bonis A., Trottier S., Manrique M. Behavioral manifestations induced by electric stimulation of the anterior cingulate gyrus in man. Rev Neurol (Paris). 1976; 132: 705-24.
7. Chatrian G.E., Bergamini L., Dondey M. et al. A glossary of terms most commonly used by clinical electroencephalographers. EEG Clin Neyrophysiol. 1974; 37: 538-548.
8. Eftekhari S., Mehrabi S. et al. BDNF modifies hippocampal KCC2 and NKCC1 expression in a temporal lobe epilepsy model. Acta Neurobiol Exp. 2014, 74: 276-287.
9. Francis L. McNaughton – report in issue No. Epilepsia. 1966; 1 (7): 80-82.
10. Geiger L.R., Harner R.N. EEG patterns at the time of focal seizure onset. Arch Neurol. 1978; 35: 276-86.
11. Gloor P. Generalized cortico-reticular epilepsies. Some considerations on the pathophysiology of generalized bilaterally synchronous spike and wave discharge. Epilepsia. 1968 Sep; 9 (3): 249-63.
12. Halasz P. Generalized epilepsy with spikewave paroxysms as an epileptic disorder of the function of sleep promotion. Acta Physiol Acad Sci Hung. 1981; 57 (1): 51-86.
13. Liu J.S., Wang J.H., Zhou J., Tang X.H., Xu L., Shen T., Wu X.Y., Hong Z. Enhanced brain delivery of lamotrigine with Pluronic® P123based nanocarrier. International Journal of Nanomedicine. 2014; 9: 3923-3935.
14. Magnus O. Reunion Europeend'information. Marseille. 1-5 September 1970.
15. Magnus O.,Van der Holst M. Zeta waves: a special type of slow delta waves. EEG Clin Neurophysiol. 1987; 67: 140-146.
16. Marcus E.M., Watson C.W., Simon S.A. An experimental model of some varieties of petit mal epilepsy: electrical-behavioral correlations of acute bilateral epileptogenic foci in cerebral cortex. Epilepsia. 1968; 9: 233-248.
17. Meldrum B.S., Rogawski M.A. Molecular Targets for Antiepileptic Drug Development. Neurotherapeutics. 2007 January; 4 (1): 18-61.
18. Noachtar S., Binnie C., Ebersole J. et al. A glossary of terms most commonly used by clinical electro encephalographers and proposal for the report form for the EEG findings. In: Deuschl G., Eisen A., eds. Reccomendations for the Practice of Clinical Neurophysiology: Guidelines of the International Federation of Clinical Neurophysiology. 2nd ed. Amsterdam. 1999: 21-41.
19. Pollen D.A., Perot P., Reid K.H. Experimental bilateral wave and spike from thalamic stimulation in relation to level of arousal. Electroenceph clin Neurophysiol. 1963; 15: 1017-1028.
20. Stefan H., Snead O.C. In: Engel J., Pedley T.A., editors. Epilepsy: a comprehensive textbook. Philadelphia. 1997: 79-590.
21. Timofeev I., Steriade M. Neocortical seizures: initiation, development and cessation. Neuroscience. 2004; 123: 299-336.
22. Williams D.A. Study of thalamic and cortical rhythms in petit mal. Brain. 1953; 76: 50-69.


Seniors in Action: Community + Connection + Conversation offers activities that provide engaging opportunities for participants to learn something new, contribute their talents and experience, and deepen their connection to the West Hollywood community. This will be an interactive experience, so be prepared to participate! Refreshments will be served.
Presented by the West Hollywood Comprehensive Services Center in collaboration with the City of West Hollywood's Senior Advisory Board.


text:
Q: ERROR:HDLCompiler:1731 - found '0' definitions of operator "+", cannot determine exact overloaded matching definition for "+" I have an error in my vhdl code. I'm using ISE design.
What should I do to solve my problem?
library IEEE;
use IEEE.STD_LOGIC_1164.ALL;
use ieee.std_logic_unsigned.all;
use ieee.numeric_std.all;
use ieee.math_real.all;

library std;
use std.standard.all;
-- Uncomment the following library declaration if using
-- arithmetic functions with Signed or Unsigned values
--use IEEE.NUMERIC_STD.ALL;

-- Uncomment the following library declaration if instantiating
-- any Xilinx primitives in this code.
--library UNISIM;
--use UNISIM.VComponents.all;

entity neuron2 is
    port ( A : in integer :=1;
                B : in integer :=2;

                D : out real);
    constant C : real := 1.25;
    constant E : real := 2.25;
    end neuron2;

architecture Behavioral of neuron2 is

begin

  D <= A+B+C+E;

end Behavioral;

I get the following error:

ERROR:HDLCompiler:1731 -
  "C:\Users\Ida\Downloads\Mojo-Base-VHDL\percobaan2\neuron2.vhd" Line
  51: found '0' definitions of operator "+", cannot determine exact
  overloaded matching definition for "+"  ERROR:HDLCompiler:854 -
  "C:\Users\Ida\Downloads\Mojo-Base-VHDL\percobaan2\neuron2.vhd" Line
  46: Unit  ignored due to previous errors.

A: A and B are integers while C and E are reals. A and B must be type converted to reals before addition:
D <= real(A + B) + C + E;

Note: Real types are not synthesisable, so I assume this is simulation only code.

redpajama_set_name: RedPajamaStackExchange


text:
Liberian Women Continue Peaceful Protest Against Amendment of Rape Law
October 18, 2017 by Gbatemah Senah
MONROVIA, Montserrado – Women representing different organizations in Liberia continue to register their displeasure with the recent amendment to the rape law by the Senate.
The Liberian Senate recently voted to amend the Rape Law, making rape bailable for all offenses and granting parole to convicted rapists.
Since then, women have staged a peaceful march from Paynesville to the grounds of the Capitol Building through the streets of Monrovia, displaying posters and chanting slogans against rape.
The walk ended at the entrance of the home of the National Legislature where they had gathered to raise their concerns with the lawmakers.
In their position statement, the women said the two major amendments defeat the purpose of having a law that would deter perpetrators, especially in the midst of the high rate of the crime.
Although there is a court in Monrovia responsible for trying cases involving sexual violence, the women are calling for more efforts in that direction.
"We call on lawmakers to be progressive by ensuring budgetary allocations and policies that further invest in the implementation of the law such as the establishment of county levels [sexual and gender-based violence] crimes unit and branches of Criminal Court E, invest in forensic technology for the preservation and gathering [of] evidence," they wrote.
"By this, we request that [lawmakers] commence a process of external engagement and consultations with stakeholders in the women's rights sector, the Association of Female Lawyers and other justice/protection groups to get concrete indications of the impact of the rape crisis on women and girls across Liberia," they advanced.
The activists also emphasized specific concerns to the current prevalence of sexual violence and the state's obligation to addressing the human rights and public health crisis.
No member of the legislature was available to listen to their concerns on the amendment, apparently because it was not a session day and the protest was held just a day before nationwide elections.
Lakshmi Moore, ActionAid's country director and a member of the Liberia Feminist Forum, said the lawmakers were earlier notified and assured that they would meet with the women on Monday.
Moore said although the lawmakers have cleverly continued to ignore their plight, the protest was successful.
"We want to tell our representatives that election is tomorrow; when we come back from election, we will be here. They should not amend the law," she said.
Moore said their aim for the march was to send out a warning to the lawmakers that the women of Liberia were prepared to fight against the amendment.
"We find it very disappointing that they waited toward the end of the government when everybody is concentrating on the elections," she added.
Women are calling on lawmakers to vote against the new amendment, noting that it is not in the true spirit of justice and equality. Photo: Gbatemah Senah
The executive director for the Women NGO Secretariat of Liberia, Marpue Speare, said the action of the senators undermines the achievements of women's rights organization, since 2005.
Although the current law does not address every challenge with fighting to end rape in the country, she said it marks a milestone in the history of their advocacies.
The current law, which was passed in 2005, was drafted with the contribution of the Association of Female Lawyers of Liberia.
It extended the definition of rape to include both genders as possible perpetrators, expanded the definition of consent and presumption of the lack thereof, and provided for a maximum of life sentences for first-degree felony rape and a maximum sentence of 10 years imprisonment for second-degree felony rape.
The law in its current state also provides for gang rape and most importantly, makes it a first-degree felony offense. It also extends the list of capital offenses under Liberian laws to include first-degree rape as a capital offense, hence non-bailable.
The Association of Female Lawyers of Liberia's President Vivian Neal said, although the senators are yet to release a copy of the draft amendment to them, their action is intended to weaken the current law.
Neal disagreed with the Senate's press statement that the punishment for rape in the 2005 amended law is excessive, thus, unconstitutional. Photo: Gbatemah Senah
She said while first-degree rape is treated under the law as a capital offense, therefore non-bailable, the same law allows bail for an accused if the proof is evident and the presumption is great because there is insufficient evidence to indict the accused.
"Rape can be bailable depending on the gravity of the case," she clarified.
According to her, the activists' issue with the Senate's action is making rape in entirety a bailable offense without any condition attached.
"It's like they are talking more for the perpetrators than the victim," she stressed.
She said if the current amendment is not resisted, the law will favor mostly wealthy perpetrators of rape who can easily afford bond fees.
The Liberian Senate voted during its 60th day sitting of the sixth session to pass a bill submitted by Sinoe's Sen. Milton Teahjay to amend the current rape law, making the act a bailable offense.
While Grand Kru's Sen. Peter Coleman filed a motion for reconsideration, the amended legislation has been submitted to the House of Representatives for concurrence. Grand Bassa's Sen. Jonathan Kaipay was the only person who voted against the bill, while Coleman filed a motion to reconsider the amendment.
While most of the senators were on official break during the vote, the standing rules governing the body grant for a simple majority of the senators duly seated to constitute a quorum.
Featured photo by Gbatemah Senah
Tags ActionAid, Association of Female Lawyers, Jonathan Kaipay, Lakshmi Moore, Liberia Feminist Forum, Liberian Senate, Marpue Speare, Milton Teahjay, Peter Coleman, Vivian Neal, Women NGO Secretariat of Liberia
Gbatemah Senah
Senah is a graduate of the University of Liberia and a recipient of the Jonathan P. Hicks Scholarship for Mass Communications. Between 2017 and 2019, he won six excellent reporting awards from the Press Union of Liberia. They include a three-time Land Rights Reporter of the Year, one time Women's Rights Reporter of the Year, Legislative Reporter of the Year, and Human Rights Reporter of the Year.
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Victims of Gender-Based Violence Remembered at Candlelight Vigil
Board Orders Disaster Management Agency Audited, Amid Reports of Irregularities
Gov't and Health Workers Hold Discussions, But Strike Still Ongoing
January 17, 2020 by Sualeh Ziamo
January 16, 2020 by Richard Williams
January 17, 2020 by Kelvin Kollie
January 17, 2020 by Gbatemah Senah
January 14, 2020 by James Suah

redpajama_set_name: RedPajamaCommonCrawl


text:
Clinical Trial For Rett Syndrome Launched
Study marks the emergence of disease-modifying treatments for autism spectrum disorders
BOSTON, /PRNewswire-USNewswire/ — Researchers at Children's Hospital Boston have begun a randomized, placebo-controlled trial to test a potential drug treatment for Rett syndrome, the leading known genetic cause of autism in girls. The drug, mecasermin, a synthetic form of insulin-like growth factor-1 (IGF-1), is already FDA-approved for children with short stature due to IGF-1 deficiency.
The trial, now enrolling patients, marks the beginning of a trend toward drug treatments seeking to modify the underlying causes of autism spectrum disorders[1], rather than just behavioral symptoms such as anxiety or aggression. It follows research in animal models, published in 2009(1), which suggested that raising IGF-1 levels can reverse features of Rett syndrome by enhancing maturation of synapses —the points of communication between brain cells.
"We expect that therapy that stimulates synaptic maturation will serve as a model for pharmacological treatment of not only Rett syndrome, but of other autism spectrum disorders," says Omar Khwaja, MD, PhD, the study's principal investigator and director of the Rett Syndrome Program in the Department of Neurology at Children's.
Rett syndrome, occurring almost exclusively in girls, is an X-linked neurodevelopmental disorder causing severe cognitive, motor and language problems and autistic behaviors. Other features include loss of purposeful use of the hands; repetitive, stereotyped hand movements; slowed brain and head growth; and heart-rhythm and breathing problems. Although affected children appear normal during their first six months of life, symptoms emerge, tragically, between 6 and 18 months of age, a prime period of synaptic development.
The three-year pilot study will randomize 40 girls (aged 2 to 12) with Rett syndrome to receive the drug, known as Increlex® (Tercica Inc., a Subsidiary of the IPSEN Group) for five months. The study will use a cross-over design, allowing girls assigned to placebo to switch to active treatment after a six-week "washout" period. The main outcome measures will be improvement in neurodevelopment and in cardiorespiratory function.
Although Rett syndrome used to be seen as a degenerative, irreversible disease, recent research indicates that brain cells aren't actually lost, and the brain is structurally normal – instead, the synapses between cells are weak, preventing brain circuits from maturing. Rett syndrome's usual cause is mutation or deletion of a gene called MeCP2, which itself controls a group of genes that regulate synaptic changes in response to input from the environment. In 2007, working with a mouse model of Rett syndrome, researchers used genetic tricks to restore MeCP2's function in the brain.(2) The mice showed a striking recovery, suggesting that Rett syndrome, even when well established, might be a treatable disease – if only synapses could be built back up.
"This was an enormous intellectual proof-of-principle that we aren't wasting time thinking of therapies for girls who are already symptomatic," says Khwaja. "Before, it was thought that if there ever was a treatment, it would have to be given before symptoms appeared, and that once the disease started it couldn't be reversed."
IGF-1, the drug used in the trial, is indirectly regulated by MeCP2. It has been shown to enhance synapse maturation, and in mice missing the MeCP2 gene, treatment with IGF-1 ameliorated several features of their Rett-like disease.(1)
"There's been a big sea change in how Rett syndrome and other neurodevelopmental disorders are viewed," Khwaja says. "The synapses are very dynamic. They need to be stabilized, and if they don't receive the right stimulus, they'll naturally disappear. That change in paradigm has really affected the way that we look at treatments, and I think it brings a lot more hope."
The new view has already affected the way schooling and education of children with Rett syndrome are being approached. "There's more and more evidence in animals that enrichment and schooling can help synapses form and strengthen," says Khwaja. "The battle is getting the girls into appropriate educational settings. If you are repetitive, and give them ways to communicate, they actually can learn, and that's probably because you're reinforcing these synaptic connections."
The clinical trial is funded by the International Rett Syndrome Foundation, Autism Speaks and Harvard University's Catalyst Pilot Awards for Clinical Translational Research. For information on enrollment, contact Katherine Barnes (katherine.barnes@childrens.harvard.edu[2]; 617-355-5230) or visit www.childrenshospital.org/rett[3].
^ trend toward drug treatments seeking to modify the underlying causes of autism spectrum disorders (www.childrenshospital.org)
^ www.childrenshospital.org/rett (www.childrenshospital.org)
^ http://www.childrenshospital.org/clinicalservices/Site1886/mainpageS1886P0.html (www.childrenshospital.org)
^ http://www.childrenshospital.org/vector/vector_fall08/making_connections.html (www.childrenshospital.org)
^ http://www.autismconsortium.org/press-releases/ac-scientists-publish-study-defining-mechanism-and-potential-treatment-for-rett-syn.html (www.autismconsortium.org)
^ www.childrenshospital.org/newsroom (www.childrenshospital.org)
^ http://vectorblog.org (vectorblog.org)
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Filed Under: Wellness Buzz Tagged With: autism, BOSTON, Children Hospital Boston, Rett Syndrome
You are here: Home / Wellness Buzz / Clinical Trial For Rett Syndrome Launched


text:
When you are faced with the problem of having too many options, Acentric concept screening surveys provide a quick, low cost way to screen out the worst concept alternatives by exposing them to a sample of target consumers. Test up to 10 alternative concepts, and get feedback on differences in interest by demographic segment and an indication of which features consumers find most appealing.
When should concept testing be used?
Concept screening surveys are ideal for the early stages of new product and service research. Concept screens can also be used to evaluate brand extensions, new value propositions, product reformulations and new business ideas. Concept screening surveys go 'broad and shallow' – testing a broad range of ideas – as opposed to concept tests which go 'narrow but deep' (testing one concept in depth).
The concept test methodology is suitable for companies, entrepreneurs and inventors wishing to test consumer product or service concepts prior to risking large investments.
Eliminate the duds. Identify the best concept(s) to take forward for further development and testing.
Determine which segments find the product concept most appealing?
Identify the most appealing features to take forward to the next round of development.
When should I choose concept screening versus conjoint analysis?
Both concept screening and conjoint analysis can be applied to the same problem. The difference is that in cases where speed and cost are important, concept screening is preferable. If these are not an issue, then you should consider conjoint analysis, as this allows a larger range of alternatives to be tested. Conjoint analysis also allows to quantify the impact of each alternative feature on purchase intention / interest ratings so that you can trade-off features with one another. Price trade-off analysis is also possible.
Maximum 10 concepts.
Standard questions – only text in angle brackets <> may be changed on the questionnaire.
Between 5 to 15 working days counted from the day after you approve the final questionnaire.
This sample report illustrates a very basic concept screening test designed to work with survey modes that require brevity, while also catering to smaller budgets. For other modes that allow greater length, and where larger budgets are available, more detail can be collected. Please indicate your requirements when requesting a quote.
Report sample


This is your chance to see what the world has to offer.
Where Should The Orange Traveler Go In 2018?
Tampa, Florida — After visiting 13 different nations and municipalities, I'm ready to explore at least two more in 2018.
Once again, I am asking for your help in selecting my next destination. Last time, you helped me decide on planning a trip to Istanbul, Turkey, and the trip was one of the best I've ever had. I saw Istanbul-based club Besiktas play Kayserispor in a Süper Lig match and did so much more.
The nations and municipalities I have visited thus far are the Vatican City, Saba, Dominican Republic, Saint Martin, Italy, France, Belgium, Turkey, Brazil, Mexico, Canada, the Bahamas and, of course, the United States.
With that in mind, where do you think The Orange Traveler should go next? Voting is permitted once per day until Jan. 2. Have other suggestions? Tell me where I should go in the comments below.


This entry was posted on 8 September, 2015 at 22:26 and is filed under ABBA, History.	You can follow any responses to this entry through the RSS 2.0 feed. You can leave a response, or trackback from your own site.


Ripley's Believe It or Not Museum - Myrtle Beach, SC. Scale Model of worlds tallest man. Robert Wadlow .... G.E.A.R. Track Day May 2016 - Bolam Family Motorsports. WonderWorks Orlando Coupons & Discounts - WonderWorks Orlando. Hollywood Wax Museum in Pigeon Forge, Tennessee | Expedia.ca.


This chart is from the Montana Climate Office at the University of Montana, courtesy of Montana Environmental Information Center (MEIC) Facebook page.
This chart represents a statistical analysis of temperatures in the state from 1895-2012. The red trend line shows that average temperatures in the state have increased 2.6°, compared to 1.6° globally. The increase is most dramatic after 1990. In 23 years since that time, only four years have been below normal.
It is stunning that our representatives in Congress continue to deny the human causes of climate change. Are you listening Steve Daines?
Oil and gas development is directly linked to climate change. We need leaders who will establish a vision for change.
This entry was posted in Uncategorized and tagged climate change, Montana Climate Office, Montana Environmental Information Center, Steve Daines. Bookmark the permalink.


The Festive Afternoon Tea at Peacock Alley just got a whole lot more exciting. Along with the delicious selection of fresh morning scones, turkey and stuffing bites served on a cranberry brioche bun, decadent Christmas inspired pastries and festive delicacies created by the hotel's talented pastry chefs, guests will also stand the chance to win one of 24 extremely special luxury gifts curated by Laings and Waldorf Astoria Edinburgh - The Caledonian as part of the hotel's 24 days of sparkle.
A white gold rubellite and diamond cluster pendant worth over £1000.


Lovely, crystal clear pool, in a secluded glen, along the banks of the Shinglekill Creek, in Purling, NY.
Picturesque camp on a woodsy forest lot. "Purling Waters" is perched on a cliff, just downstream and on the opposite bank, from our main property Tumblin' Falls House. It is a small gem, close to everything, but beautifully hidden. Magical!


Related changes can be observed in recent art criticism and art history. Grant Kester has persuasively critiqued theory's conventional application in contemporary art writing, describing it as "a straightforward exegesis, in which a given theory, reduced to a set of notional principles, is simply juxtaposed with a given work of art, as if their sheer coexistence within the space of the essay constitutes meaningful evidence of their analytic co-relevance."2 In Kester's assessment, theory has been reduced to a kind of trans-historical, trans-cultural utility kit, ready to be applied to any and all forms of artistic production and whose success at unlocking the mysteries of the visual is taken to be preordained. Such an approach pays little mind to the specific conditions from which a given theoretical discourse originates or how the work of art might resist or complicate the theoretical directives that have been foisted upon it. For Kester, the result is an intellectually diminished form of art criticism, "in which primary importance is assigned to the ability to explicate theoretical texts in more simple or accessible terms than those in which they were originally conveyed."3 This view is no doubt a simplification that more accurately characterizes graduate seminar writing than the best theoretical criticism. Furthermore, we should remember that all forms of art writing—even formal analysis—have their own discursive substructures whose "analytic co-relevance" to the work of art is accepted as self-evident. Nonetheless, I found myself nodding vigorously as I read Kester's bracing call to consider how theory can fail to take the true measure of a work of art.
Like Kester, Shannon believes that art neither can nor should be subsumed by theory without remainder, and he raises the significant question of the division of labor between artist, theorist, and art historian. Is art history's task merely finding the right theory that "speaks" for the silent art object, or can it illuminate a set of cultural conditions by triangulating between theory and art in a manner that respects the ambiguities and ambivalences intrinsic to visual expression?
I believe that the points I have outlined here—however cursorily—point to the possibility of a generational shift in art's relationship to theory. Younger artists see no reason to be beholden to a theoretical edifice codified well before they were even born. And art writers are becoming more sensitive to the ways in which works of art can articulate their own theoretical positions that do not depend on the imprimatur of an extrinsic written corpus for their legibility. While in some quarters these developments might signal a loss of intellectual rigor, my hope is that they reflect a kind of disciplinary rebalancing, part of the ongoing task of keeping the house of art free of mice and ghosts.
1 Erwin Panofsky, "The History of Art as a Humanistic Discipline," in Meaning in the Visual Arts (Chicago: University of Chicago Press, 1955), 22.
2 Grant Kester, "The Device Laid Bare: On Some Limitations in Current Art Criticism," e-flux 50 (December 2013).
4 Joshua Shannon, "We Are Pop People," review of The First Pop Age, by Hal Foster, Art Journal 71, no. 4 (Winter 2012): 121.
MATTHEW L. LEVY is an assistant professor of art history at Penn State, Erie. His essay "David Novros's Painted Places" was recently published in the catalogue for Novros's current exhibition organized by the Museum Wiesbaden and Museum Kurhaus Kleve.


text:
Health Care, Regulation
An Alternative To Regulation of Opioids?
From Sy Mukherjee at Fortune comes the tale of an interesting study and approach to reducing the prescribing of addictive opioids: write a letter.
"A simple letter, supportive in tone, to inform clinicians of a scheduled drug harm to their patient resulted in fewer subsequent opioids dispensed by those clinicians," wrote the study authors, adding that, so far, "traditional state regulatory approaches to limiting opioid prescribing have not achieved great success."
Admittedly, the overall effect of these letters, highly personal missives from the families of opioid victims, were modest. But by no means were they negligible, according to the study. In fact, doctors informed of patient deaths through these personal communications were 7% less likely to prescribe opioids for new patients, and less likely to prescribe high-dose opioid painkillers, over the course of the next three months compared to those who didn't. It may not sound like much, but in the midst of a scourge claiming tens of thousands of lives every year, the public health effect isn't something to be easily brushed aside.
Moral of the study for me: you can persuade people when you offer a real-world rational argument, particularly one that touches the heart. Let's make regulation the last resort, not the first.
Our Jon Sanders advocates for the 'regulate as a last resort' approach in a different context — that of mandatory licensing of those who want to work in certain fields. A 2015 report shows that more than 20 percent of North Carolina's workforce is licensed.
Whether it's the prescribing of addictive pain killers or ensuring public health and safety by those who work in certain fields, there are alternatives to government regulation we should consider.
Last Thing We Need Is Biden's Medicaid Expansion Scheme
NC Medicaid Expansion: A Political Loser Then and Now
Significant Certificate-of-Need Reforms On The Way To The Governor's Desk


text:
Arbitration,	Automatic Stay
"Release the Kraken" – S.D.N.Y. Affirms Denial of Arbitration, Rules That Determinations Regarding Property of the Estate Belong In Bankruptcy Court
Contributed by Doron P. Kenter.
In a recent case out of the Southern District of New York, the court affirmed a denial of a motion for relief from the automatic stay to proceed with arbitration, ruling that the liquidating trustee was not bound by the arbitration clause in the debtor's prepetition consignment agreement and holding that the interests of other creditors militated in favor of a determination by the Bankruptcy Court regarding whether certain consigned artwork was property of the estate.
In In re Salander-O'Reilly Galleries, LLC, a prepetition consignor moved the bankruptcy court for relief from the automatic stay to allow arbitration to proceed regarding the proper ownership of a painting, "Madonna and Child," by Sandro Botticelli, valued at more than $8.5 million. Prior to Salander-O'Reilly's bankruptcy, Kraken Investments Limited, a limited company with its principal place of business in Jersey, Channel Islands, entered into a one-year consignment agreement with Salander-O'Reilly, pursuant to which the gallery would feature the painting at an exhibition and use its best efforts to sell the painting. That agreement referred all disputes between the parties to arbitration in the Channel Islands and stated that Channel Islands law would control in such arbitration. Kraken delivered the Botticelli to the gallery, but did not file a UCC-1 financing statement registering its interest in the painting. Days before the gallery's bankruptcy filing, Kraken commenced a state court action in New York, seeking seizure of the painting. The action was automatically stayed upon the commencement of Salander-O'Reilly's bankruptcy case.
Through court-approved procedures in the chapter 11 case, Kraken sought a determination from a special panel (established to handle requests for returns of consigned artwork) that the painting was not property of the estate under section 541 of the Bankruptcy Code, but was instead its own property, and merely on consignment with the gallery. When mediation through this process failed, Kraken moved for relief from the automatic stay so as to enter into arbitration in the Channel Islands pursuant to the consignment agreement. The bankruptcy court denied the motion, concluding that (i) the liquidation trustee for the debtor (who had succeeded to the debtor's interest in the Botticelli) was not a party to the consignment agreement and was therefore not bound by the arbitration clause; and (ii) for policy reasons, the bankruptcy court (and not an arbitrator) should resolve the question of whether the liquidation trustee could avoid unperfected liens pursuant to section 544 of the Bankruptcy Code.
On appeal, the district court affirmed the bankruptcy court's decision for the same basic reasons. First, the court observed that the liquidation trustee's rights (as successor to the estate) to avoid unperfected liens were in its capacity as a creditor of the debtor (rather than as a successor to the debtor's own interests). Because the trustee was not "stepping into the shoes" of the debtor, but rather exercising the rights of a creditor (either under section 544 of the Bankruptcy Code or as assignee of a lender's prepetition lien), it was not a party to the consignment agreement – at least for the purposes of arbitrating the dispute before the court regarding the ownership of the painting. Indeed, as the court noted, the dispute was "not simply an issue between Kraken and [Salander-O'Reilly]," but rather, between Kraken and the debtor's estate. Accordingly, the liquidation trustee was not bound by the arbitration clause.
Second, the district court concluded that, even if the liquidation trustee had been bound by the arbitration clause, the bankruptcy court did not err in denying arbitration on a policy basis, after weighing the conflicting interests of federal arbitration law and the Bankruptcy Code. The district court first observed that, in appeals regarding core proceedings, it must show due deference to determinations by the bankruptcy court regarding these competing policy interests. It then held that determinations regarding what constitutes estate property are constructs of section 541 of the Bankruptcy Code and are, at least in this case (and probably in most, if not all, cases), core proceedings "aris[ing] under" the Bankruptcy Code. The court further noted that determinations regarding estate property have "no existence outside bankruptcy" and would also constitute core proceedings "arising in" the bankruptcy case, and that, in any event, Kraken had filed a proof of claim in the bankruptcy case, thereby triggering core jurisdiction under 28 U.S.C. § 157(b)(2)(B) for "allowance or disallowance of claims against the estate."
The district court then found that the bankruptcy court had not abused its discretion in concluding that the interests of the Bankruptcy Code – including its goals of aggregating all estate property and of centralizing disputes in a single forum – outweighed the interest of the Federal Arbitration Act, insofar as it recognizes the enforceability of the arbitration clause pursuant to which Kraken wished to protect its own interests. Indeed, the court observed that, "[i]f every dispute as to whether property was part of the bankruptcy estate … were sent to arbitration pursuant to a pre-petition arbitration agreement, unreasonable delay, costs, and duplication of effort would result for all parties involved in the bankruptcy as well as the courts."
In so holding, the district court recognized that Kraken's frustration (even "outrage") at the possibility that the debtor's creditors might share in the proceeds of the sale of a painting allegedly owned by Kraken. It observed that the bankruptcy court had not yet determined the nature and extent of Kraken's interest in the painting, and that the only issue before the court was whether such dispute should be resolved in the bankruptcy court or by an arbitrator in the Channel Islands. Though the court's sympathies are well-taken, they may be cold comfort, as it seems clear under bankruptcy law that the liquidating trustee may avoid a lien where a consignor has failed to perfect its security interest by filing a financing statement. Though this result may seem unfair to Kraken, the courts in Salander-O'Reilly have provided useful guidance for holders of security interests and for those attempting to enforce prepetition arbitration clauses in bankruptcy proceedings.
Supreme Court Will Tell Us Soon if Creditor Violates Automatic Stay by Passively Retaining Debtor's Property
Automatic Stay,	Case Overviews,	Jurisdiction & Appeals,	Rules & Procedures
Denial of Stay Relief is a Final Order, Says the U.S. Supreme Court
Case Overviews,	Chapter 11 Plans,	Fees,	Jurisdiction & Appeals,	Post-Confirmation Issues,	What We're Watching
In re Buffets: A Fees-t for the United States Trustee


Help for hurricane victims through United Way.
On October 18, 2005, 28 local United Ways and one state organization became recipients of the first awards from the United Way Hurricane Response and Recovery Fund. The grants total more than $4.2 million of the more than $8 million in contributions made to the fund to date. The communities receiving the grants span the Gulf Coast from Texas to Alabama. The fund will award additional grants within the next few weeks.
The United Way Hurricane Rita Fund.
All gifts through the funds will be allocated for both front-line disaster relief and long-term recovery needs as determined by local United Ways in affected areas in coordination with a vast network of human services agencies and volunteer centers.
To give directly to any of the three United Way Hurricane Funds, click here to make a secure online gift.
Please make all checks payable to United Way of America and reference the appropriate hurricane fund in the memo.
United Way Hurricane Katrina Relief and Response Fund — code AG2882.
For companies pledging online through United eWay, the three hurricane response funds can be found under the "Locate an Agency" panel.
Volunteer opportunities to assist hurricane victims in our 40-town region can be found by clicking here for United Way of the Capital Area's Volunteer Solutions. Enter "hurricane" in the KEYWORDS section to search the current list of opportunities. The list changes often so consider completing the free registration to save your interests for fast future searches. You can also choose to receive email updates that let you know of any new opportunities that match your interest.


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Q: Count occurrences of values across multiple columns I am having a terrible time finding a solution to what I am sure is a simple problem.
I started an app with data in Lists of objects. It's pertinent objects used to look like this (very simplified):
class A {
    int[] Nums;
}

and
List<A> myListOfA;

I wanted to count occurrences of values in the member array over all the List.
I found this solution somehow:
var results
    from a in myListOfA
    from n in a.Nums
    group n by n into g
    orderby g.Key
    select new{ number = g.Key, Occurences = g.Count}

int NumberOfValues = results.Count();

That worked well and I was able to generate the histogram I wanted from the query.
Now I have converted to using an SQL database. The table I am using now looks like this:
MyTable {
  int Value1;
  int Value2;
  int Value3;
  int Value4;
  int Value5;
  int Value6;
}

I have a DataContext that maps to the DB.
I cannot figure out how to translate the previous LINQ statement to work with this. I have tried this:
MyDataContext myContext;

var results =
    from d in myContext.MyTable
    from n in new{ d.Value1, d.Value2, d.Value3, d.Value4, d.Value5, d.Value6 }
    group n by n into g
    orderby g.Key
    select new { number = g.Key, Occurences = g.Count() };

I have tried some variations on the constructed array like adding .AsQueryable() at the end - something I saw somewhere else. I have tried using group to create the array of values but nothing works. I am a relative newbie when it come to database languages. I just cannot find any clue anywhere on the web. Maybe I am not asking the right question. Any help is appreciated.

A: I received help on a microsoft site. The problem is mixing LINQ to SQL with LINQ to Objects.
This is how the query should be stated:
var results =
    from d in MyContext.MyTable.AsEnumerable()
    from n in new[]{d.Value1, d.Value2, d.Value3, d.Value4, d.Value5, d.Value6}
    group n by n into g
    orderby g.Key
    select new {number = g.Key, Occureneces = g.Count()};

Works like a charm.

A: If you wish to use LINQ to SQL, you could try this "hack" that I recently discovered.  It isn't the prettiest most cleanest code, but at least you won't have to revert to using LINQ to Objects.
var query =
    from d in MyContext.MyTable
    let v1 = MyContext.MyTable.Where(dd => dd.ID == d.ID).Select(dd => dd.Value1)
    let v2 = MyContext.MyTable.Where(dd => dd.ID == d.ID).Select(dd => dd.Value2)
    // ...
    let v6 = MyContext.MyTable.Where(dd => dd.ID == d.ID).Select(dd => dd.Value6)
    from n in v1.Concat(v2).Concat(v3).Concat(v4).Concat(v5).Concat(v6)
    group 1 by n into g
    orderby g.Key
    select new
    {
        number = g.Key,
        Occureneces = g.Count(),
    };

A: How about creating your int array on the fly?
var results =
    from d in myContext.MyTable
    from n in new  int[] { d.Value1, d.Value2, d.Value3, d.Value4, d.Value5, d.Value6 }
    group n by n into g
    orderby g.Key
    select new { number = g.Key, Occurences = g.Count() };

A: In a relational database, such as SQL Server, collections are represented as tables. So you should actually have two tables - Samples and Values. The Keys table would represent a single "A" object, while the Values table would represent each element in A.Nums, with a foreign key pointing to the one of the records in the Samples table. LINQ to SQL
's O/R mapper will then create a "Values" property for each Sample object, which contains a queryable collection of the attached Values. You would then use the following query:
var results =
    from sample in myContext.Samples
    from value in sample.Values
    group value by value into values
    orderby values.Key
    select new { Value = values.Key, Frequency = values.Count() };


The former PM was dressed in a white jacket complete with cigar and cat to perfect the Bond villain look.
After the shock general election result, Conservatives are scrambling to piece together a working government – but one former PM seems to be enjoying his time away from Westminster.
A photo of David Cameron appeared on Instagram over the weekend with the former Tory PM dressed as James Bond villain Emilio Largo.
Stood next to a similarly dressed friend, it appears Cameron was attending a fancy dress party, opting to go as the Thunderball villain.
The photo was soon deleted but was initially posted by Cameron's sister-in-law, Lohralee Astor.
With a white jacket, black eyepatch, black gloves, a cigar and a toy cat under his arm, Cameron had made a good effort to dress as Largo.
The caption under the photo read: "Didn't know Emilio Largo could look so good! Handsome brother in laws #jamesbond #villain."
Since his sudden departure from day-to-day politics in summer 2016, Cameron has been keeping a relatively low profile, embarking on a speaking tour in the US as well as being named as president of the dementia charity Alzheimer's Research UK.
He made the headlines earlier in the year after revealing he had purchased a luxury shed for his garden costing £25,000 in which he will write his memoirs.
It comes after a busy few weeks for Cameron after intense campaigning for the snap general election which saw the Tories lose their commons majority.


Fast pace, but a great trip!
The booking service was great. Very responsive on the phone and by email.
CIE representatives are always efficient and courteous. This was my second trip with CIE, and I have already booked a third.
For a first time visiting Ireland the CIE bus tour is a great choice.
We really enjoyed the CIE bus tour. Every detail was taken care of, the rooms were great and meals were good. When we arrived at the next destination our luggage was always delivered to our room.
Booking was easy. All of my questions were answered. When I called about not receiving my "Go To Guide" I was sent on by mail and also sent a PDF of the brochure in case the mailed one did not arrive before our departure.
I loved the Tour, The Guide and the Great Group of People on the Bus Tour.
The CIE tour was wonderful and booking was easy. Everyone, from the CS to the Guides, was friendly, knowledgable, helpful and kind.
This tour was the first my husband and I every went on. It was fantastic. Enjoyed the driver,hotel,food, tours and planning. I recommended this tour to two of my friends. I would definitely use your tour company again.
It was easy. I researched this trip a lot and feel like we got a great trip for an excellent price. The website was easy and if I needed to speak to someone, they were available and friendly.
Booking through CIE took the guess work out of everything and I didn't have to worry about a thing before, during, or after.


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Xinshe is a city near the mountainous area in the middle of Taiwan, famous as the place of origin of fresh mushrooms. The Xiao-Shi-Mi shortbread is made of the high-quality dried mushrooms produced in Xinshe. The packaging design adopts hand-drawn illustrations of local characteristics, such as the Sea of Flowers and animals common to the region. Three boxes with different motifs are included in a decorative gift box. Due to their shape and colour scheme, the individual elements combine to form a harmonious whole.


First, I enlarge my chosen knot to use as a template.
Then, I trace each of the paths of the knot on fusible web, fuse to fabric, and cut out as separate loops.
Next, I use the printed knot as placement guide. I weave the knot from the bottom up, so I locate where the paths go "under" another path near the top of the knot and cut open the loop. I layer the bottom row of loops according to the guide, and pin through all layers (fabric and paper).
Then I weave the paths over and under each other, row by row. I pin the two layers of fabric together at each intersection, but not to the paper beneath.
. . . weaving . . .
The entire knot can be lifted and treated as a single unit at this point. I unpin the bottom row from the paper guide (keeping the layers of fabric together). There is no problem sliding the knot off the paper guide and into position on the background fabric.
I move the piece to my ironing table. I carefully remove all the pins. After a final check of "overs" and "unders" for each path, I fuse the knot in position. From here, I can zig-zag the raw edges, and embellish at will (possibly an embroidered design down the center of each path).
Celtic knot Tree of Life, part six . . .
Celtic knot Tree of Life, part five . . .
Celtic knot Tree of Life, part eight . . .
It looks very complicated, and you are extremely generous to share your technique.
Thank you, Madeline. It's not as complicated as it looks (once you get the hang of it). I'm working on better written directions for the weaving process. According to the pictures above, "magic happens," LOL!!


XML Serialization can enable you to convert any common language runtime objects into XML documents or streams and vise versa. The XML Serialization makes it possible to convert XML documents into such a meaningful format that all programming languages can process the converted documents without any difficulty. It is also possible for you to transfer or transport the objects serialized to XML in an open standards compliant and platform agnostic manner.
The XML Serialization process in .NET Framework can make you to serialize objects into XML format that can conform to the specific XML Schema Definition (XSD) schema or even to the serialization format that has been defined in the SOAP specification. During any XML Serialization only the fields of objects that hold public properties alone are serialized. You must also be aware that during the XML Serialization it may not be possible all the time to preserve the type fidelity.
For instance, the Book object in a Library namespace cannot be deserialized into a same type of object and this indicates that there is no necessity for the target machine to have the same type of object and hence you can transfer or transport objects that has been serialized using XML Serialization in one machine to another machine even in the absence of original type in the target machine.
The XML documents that have been converted to objects by XML Serialization are strongly typed. A schema that has been written in XSD (XML Schema Definition) Language will be able to associate the information on data type with that of the attributes and elements of an XML document. The XML Serializer using the information of the data type in the schema converts the XML documents into strongly typed classes.
Further, the XML Serializer class can also be made for deserializing and serializing objects and with the help of the XML Schema Definition Tool you will be able to create classes meant for serialization. While serializing an object as XML with the XMLSerializer class, you can have full control over the process and while creating the XML Web Service, you have to apply all the attributes that control serialization to classes and members, so as to ensure that the envisaged XML output conforms to a particular schema always.
While using the XML Serializer, you can have a control over the need of a field or property to be encoded either as an attribute or an element. Further, while using the XML Serializer for specifying the name of an attribute or an element you can also additionally specify the XML namespace in the event of a field or property name becomes inappropriate.


It's all about connections that you can make with your audience.
You've got a great marketing idea, and a plan to execute it. You're all ready to go for the all important Spring Inventory Clearance sale. The ads are set, the in-store signage and price tags are ready to be set out, and you have a direct mail piece ready to go to all of the customers in your database.
Here's where you can consider adding the spice to make the marketing plan really sizzle. It's all about connections that you can make with your audience. These extra steps enhance involvement with your sale and your message.
While a number of campaigns can be successful with just direct mail a majority will benefit from adding other services like email marketing and web banner ads to their marketing plan. A newer service that Spectrum Marketing offers is IP Targeted Web Banner ads. These ads are sent to the same people who received your direct mail piece and are based off of physical addresses' IP address. With a regular web banner campaign add-on the ads are targeted based off email opens. The email address list used is based in the same geographic location which means that users must be opted-in to receive emails via a database and then served the ads. With IP Targeted Web Banner ads the physical mailing list is matched typically to 50-70% and then served directly to the users over a period of time. Using verified, offline data to reduce and/or eliminate non-human bot traffic, your company will get recognized and receive more quality leads. IP Targeting also meets HIPAA compliancy.
Email marketing is still a great way to build your sales. While not as powerful as direct mail in ROI, email marketing as an add-on to your campaign can be helpful to remind your customers about your campaign and immediately direct them to your online store, site, or landing page. Directing to an online coupon or offer can result in even more activity and a better bottom line. Remember, customers need to see your marketing pitch at least 7 times before they make a purchasing decision. Email marketing and online banner ads are two fantastic ways to keep reminding your customers about your sale or promotion and are especially great for newer stores and grand openings.
What's on your windows? When you are having any type of sales event, the windows should be used to blast out the message. Use clings that are removable and inexpensive to attract the attention of everyone passing your windows. They become more relevant because the message is one of urgency and is directed at people who not only come in to your business, but come in to save during the special sale time period. The design should be explosive, and Spectrum's 20 plus designers know how to make your simple sale message become an exciting magnet to bring people in.
Think about your mail piece. What about a scratch-off offer? The scratch-off is almost irresistible to people who receive mail. They want to see what is under the circle. Your Spectrum account executive can show you ways to make the scratch-off work that are incredibly cost effective. You will notice the enhanced response.
How about in-store coupons? These are small, business card sized hand outs that are very inexpensive to produce but result in a huge ROI. With rounded corners on glossy stock, these hand outs can feature special sale items, or can be a coupon good for that day only on whatever merchandise you choose. Simple, but they are a highly effective way to get your prospects more involved with your sale message.
When it comes to marketing, don't just get by. Add all the spice necessary to make your marketing plans go over the top!
Every year there are new emerging technologies and new practices that can help you rise above your competition. Only by adjusting your plan to include new directions and reach more customers can your business continue to thrive. Contact Spectrum Marketing today to learn how we can help you with your marketing results.


Welcome to Year 4, your child has now been in the school for four years and they are heading towards that all important 'top juniors'. They will have high expectations placed on them, both in their lessons, as they tackle new and exciting topics and in terms of being good role models to younger pupils. They will be encouraged, through their various subjects, to ask questions, use research techniques to try to answer questions independently and to challenge themselves on how work can be presented and displayed to the highest standard.
We have an exciting year ahead for your child in Year 4 and we are sure that they will enjoy the topics that we are covering. Have a look at Our Learning Plans to find out more about what we are learning in school. Class newsletters will be sent out termly, advising of forthcoming events and updating you on your child's progress. Mrs Roxborough will be teaching on Wednesday and Thursday afternoons.
Please check our page regularly through the year to see what we have been doing in Year 4.
In Year 4 each child will have a learning log which lasts one term. These will have tasks that cover the learning in the classroom, as well as giving children the opportunity to express and celebrate their talents. Please feel free to help your child with these tasks. Along with this, reading with your child every night will help improve their reading. Children will also be given spellings every week. They will be given out on a Friday and they will be tested the following Friday.
In Spring term Year 4 go swimming every Wednesday afternoon. Your child will need a swimming costume, towel and hat.
Select our Class News and Our Learning Plans to find out more about life in Year 4.
ClassDojo is a communication app for the classroom, each child has their own character that collects their points for them. At St. Wilfrid's we use ClassDojo to reward children for good behaviour, following school rules, fantastic work or being a good role model to others. At the end of each week/half term the child with the most Dojo's wins a prize.
We also use ClassDojo to keep parents informed about what we have been doing, sending class messages to all parents about the work we have been doing in class and then also sending private messages to parents celebrating their own child's achievements.


I came up with this idea after about a week of eating the same old boring meals of just throwing together something quickly without putting in any thought. I really needed to try something diffferent. These cauliflower steaks are relatively simple to make, and chances are you've probably got most the ingredients sat in your cupboard right now.
One cauliflower will make 2 steaks and a few extra florets, so you'll need to adjust the recipe accordingly for how many you need.
Remove the leaves from the cauliflower but leave the stalk, this will hold the steaks together when you're cooking them. Cut the cauliflower in half and then, making your steaks about 1 inch thick, cut the steaks from the centre side of each half. You'll get 2 steaks and some leftover florets that you can cook too!
Grate your ginger on a fine grater and crush your garlic, then in a small bowl mix them together with all your other ingredients.
Using a brush, coat both sides of your steaks in the marinade and then lay on a papered baking tray. You can use any leftover marinade for the spare florets.
Foil the tray and bake for 15 minutes at 180c, the remove the foil and bake for a further 10 minutes, turning halfway through.
Heat a pan with 1 tablespoon of oil and then fry your steaks for a couple of minutes on each side, watching they dont burn.
Serve with your choice of accompaniments!


1) Find the class mark of each interval by taking the average of the upper and lower limits.
For example, the class mark of the interval 10 < 20 is (20+10)/2 = 15.
3) Enter the data points using matrices.
Enter the products in one matrix and the frequencies in another matrix.
4) Note that the mean of a grouped data set is calculated by dividing the sum of the products for each interval by the sum of the frequencies. Use the sum function to find the average by entering sum(A)/sum(B).
The monthly salaries of 20 selected employees at a company are listed in the frequency distribution table below. What is the average monthly salary of these employees?
1) Find the class mark of each interval.
2) Enter the products of the class mark and number of employees (frequency) in matrix form.
3) Enter the frequencies in matrix form.
4) Find the average by entering sum (S)/sum (F).


text:
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https://www.last.fm/music/Toranja
Toranja is a portuguese rock group consisting of: Tiago Bettencourt - Vocals, guitar, piano Ricardo Frutoso - Guitar Dodi - Bass Rato - Drums They edited two albums, the first called "Esquissos" (2003) and the second "Segundo" (2005). You can check their (portuguese) website here. View wiki
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Formed in Olympia, Washington, USA in 2008, Milk Music are a very loud four-piece who make cosmic, electric, soul rock on the subject of life and the human condition. Sonically, their songs have often been compared to those of the Wipers, Neil Young & Crazy Horse, Hüsker Dü, the Velvet Underground, the Gun Club, and the Meat Puppets.
Halloween Music music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Halloween Music
Listen to music from Halloween Music like Adams Family Theme Song, Haunted Waltz & more. Find the latest tracks, albums, and images from Halloween Music.
Smart-Music.Net music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Smart-Music.Net
Listen to music from Smart-Music.Net like Mehmet Irdel - Gut (GUTted Remix), DJ Olive - Round Fire Strut & more. Find the latest tracks, albums, and images from Smart-Music.Net.
Strategic Music music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Strategic Music
Listen to music from Strategic Music like Beautiful Delusion. Part II, Placid Energy & more. Find the latest tracks, albums, and images from Strategic Music.
Music On Canvas music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Music On Canvas
Listen to music from Music On Canvas like Upside Down. Find the latest tracks, albums, and images from Music On Canvas. Listen to music from Music On Canvas like Upside Down. Find the latest tracks, albums, and images from Music On Canvas. Playing via Spotify Playing via YouTube.
UCA camp music music, videos, stats, and photos | Last.fm
https://www.last.fm/music/UCA camp music
Listen to music from UCA camp music like Nelly, Go State & more. Find the latest tracks, albums, and images from UCA camp music.
Centergy Music BMI music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Centergy Music BMI
Listen to music from Centergy Music BMI. Find the latest tracks, albums, and images from Centergy Music BMI.
CLOOB MUSIC music, videos, stats, and photos | Last.fm
https://www.last.fm/music/CLOOB MUSIC
Listen to music from CLOOB MUSIC like ROSINKA CLUBNYAKI (1), децл... & more. Find the latest tracks, albums, and images from CLOOB MUSIC. Listen to music from CLOOB MUSIC like ROSINKA CLUBNYAKI (1), децл... & more. Find the latest tracks, albums, and images from CLOOB MUSIC. ... Login; A new version of Last.fm is available, ...
SIIS-MUSIC music, videos, stats, and photos | Last.fm
https://www.last.fm/music/SIIS-MUSIC
Listen to music from SIIS-MUSIC like Zimbawe, Llorarás conmigo & more. Find the latest tracks, albums, and images from SIIS-MUSIC.
3ABN Music music, videos, stats, and photos | Last.fm
https://www.last.fm/music/3ABN Music
Three Angels Broadcasting Network, or 3ABN for short, is a nonprofit, 24-hour television and radio network that primarily focuses on Christian and health-oriented programming. It is an independently owned and operated ministry, not funded by any church or denominational group; however, it supports the Seventh-day Adventist Church.
lobby music music, videos, stats, and photos | Last.fm
https://www.last.fm/music/lobby music
Listen to music from lobby music like Prod Psymun, Smooth Love & more. Find the latest tracks, albums, and images from lobby music.
Flicker Music music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Flicker Music
Listen to music from Flicker Music like Forever and Grooved To Tears. Find the latest tracks, albums, and images from Flicker Music.
Music From The Vatican music, videos, stats, and photos ...
https://www.last.fm/music/Music From The Vatican
Listen to music from Music From The Vatican like Mater Ecclesiae, Advocata Nostra & more. Find the latest tracks, albums, and images from Music From The Vatican.
WorldStar Music music, videos, stats, and photos | Last.fm
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Listen to music from WorldStar Music like My Heart Will Go On, Greatest Love Of All & more. Find the latest tracks, albums, and images from WorldStar Music.
iTRAIN - Music music, videos, stats, and photos | Last.fm
https://www.last.fm/music/iTRAIN - Music
Listen to music from iTRAIN - Music like iTREAD Top40 HitMix Set25 Music Only. Find the latest tracks, albums, and images from iTRAIN - Music.
Relaxing Music music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Relaxing Music
Listen to music from Relaxing Music like 童神, フライ・ミー・トゥ・ザ・ムーン & more. Find the latest tracks, albums, and images from Relaxing Music.
Bamboo Music music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Bamboo Music
Bamboo Music from the lowlands of the Netherlands (handmade bamboo flutes). All instruments & samples produced & recorded by J.Derwort ABOUT Bamboo Music - Bamboo flute that takes you across the plains of Africa and through Japan before landing you in the middle of a Native American ceremony.
Best Relaxing Spa Music music, videos, stats, and photos ...
https://www.last.fm/music/Best Relaxing Spa Music
Listen to music from Best Relaxing Spa Music like Contemplation, Heavenly Space & more. Find the latest tracks, albums, and images from Best Relaxing Spa Music.
Bethel Music music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Bethel Music
BETHEL MUSIC is a ministry of Bethel Church, located in Redding, California. The mission of Bethel Church is "REVIVAL… the personal, regional, and global expansion of God's kingdom through His manifest presence."
Yes! Fitness Music music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Yes! Fitness Music
Listen to music from Yes! Fitness Music like Scream & Shout (feat. MC Joe & the Vanillas), We Are Young & more. Find the latest tracks, albums, and images from Yes! Fitness Music.
Mali Music music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Mali Music
Jamaal "Mali Music" Pollard was born on January 12, 1988 in Phoenix, AZ. The Savannah based singer, songwriter, producer is breaking out of conventional gospel music. Mali Music began playing piano at age 5 and wrote his first song at age 8 and has been actively pursuing his music… read more
AiB music, videos, stats, and photos | Last.fm
https://www.last.fm/music/AiB
Listen to music from AiB like Every Bollywood Party Song Feat. Irrfan, Honest Engineering Campus Placements | Part 03 & more. Find the latest tracks, albums, and images from AiB.
Gem music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Gem
GEM is a rock band from Utrecht, The Netherlands. 2. Gem is a 1990s band from Ohio with members from Guided By Voices, Doug Gillard and Tim Tobias. 3. GEM (Girls Entertainment Mixture) are a Japanese idol group and are the 3rd group to stem from iDOL Street. Sister group of SUPER☆GiRLS and Cheeky Parade.(PLEASE! CORRECT TAG TO GEM) 4.
Bok Bok music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Bok Bok
Listen to music from Bok Bok like Pure Shores - HXC Mix, Melba's Call (feat. Kelela) & more. Find the latest tracks, albums, and images from Bok Bok.
6pm music, videos, stats, and photos | Last.fm
https://www.last.fm/music/6pm
Listen to music from 6pm like Hate=Wellbeing=Exit. Find the latest tracks, albums, and images from 6pm.
Ar Log music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Ar Log
Ar Log is a Welsh band playing traditional music. Their name is Welsh for "For Hire". Ar Log has been performing and recording since 1976; the original members were Dave Burns (guitar), Dafydd Roberts (triple harp, flute), Gwyndaf Roberts (knee harp and bass), and Iolo Jones (fiddle…
Tsu music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Tsu
Listen to music from Tsu like ラベンダー, The Distance & more. Find the latest tracks, albums, and images from Tsu.
HCR music, videos, stats, and photos | Last.fm
https://www.last.fm/music/HCR
Listen to music from HCR like Dziekuje Wrogom, Zawrot Glowy & more. Find the latest tracks, albums, and images from HCR.
SPR music, videos, stats, and photos | Last.fm
https://www.last.fm/music/SPR
Listen to music from SPR like Cha Cha Cha, Dope Rider & more. Find the latest tracks, albums, and images from SPR.
任劍輝, 白雪仙 music, videos, stats, and photos | Last.fm
https://www.last.fm/music/任劍輝, 白雪仙
Yum Kim Fai, 任剑辉 (1912-1989) is one of the major figures in "Cantonese Opera", her performing career lasted over 30 years. Her role catagory would be "Sui Sung" Junior Male vocals and her singing catagory is "Ping Hau" or Male Voice. Yum was considered the 'Darling of Cantonese Opera'.
SBM music, videos, stats, and photos | Last.fm
https://www.last.fm/music/SBM
SBM, tedy Schola brněnské mládeže nebo-li "pokolínsky" Kalíšci. Protože naši zpěváci nepocházejí z jedné farnosti, ale z různých koutů nejen brněnských, ale i mimobrněnských, zdálo se nám Brno jako dostatečně obecné pro volbu názvu Schola brněnské mládeže.
agy music, videos, stats, and photos | Last.fm
https://www.last.fm/music/agy
Listen to music from agy like Arvedávgi (Rainbow), Supercrush & more. Find the latest tracks, albums, and images from agy.
G"‡ Žj music, videos, stats, and photos | Last.fm
https://www.last.fm/music/G"‡ Žj
Scrobble from Spotify? Connect your Spotify account to your Last.fm account and scrobble everything you listen to, from any Spotify app on any device or platform.
KMC music, videos, stats, and photos | Last.fm
https://www.last.fm/music/KMC
There are 6 artists named KMC: 1) Ken Marlon Charles a.k.a KMC (born January 5, 1971) is a soca artist from Trinidad. Famous for hits like "Soul on Fire", "Soca Bashment" and "Bashment to Carnival", KMC is signed to the US-based record label Sequence Records.
ID/PSA music, videos, stats, and photos | Last.fm
https://www.last.fm/music/ID/PSA
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Everything music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Everything
Everything is a pop/rock band from Virginia. They were most active in the mid to late '90s and early '00s. The band was formed in 1990 by students at James Madison University. Going on the road full time in '92, they played 200-250 shows a year for nearly the next 10 years, starting in the mid-Atlantic, and then gradually expanding their grass ...
KPN music, videos, stats, and photos | Last.fm
https://www.last.fm/music/KPN
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pH-1 music, videos, stats, and photos | Last.fm
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Six Pak music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Six Pak
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Anu music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Anu
There is more than one artist with this name: 1). ANU is a Tibetan rap group. They were founded in 2016 by Gong Ba and Baya. They are from Nangqian County, northwest China's Qinghai province. In July 2016, ANU released their first EP ANU, which included two songs, ANU and Living Hometown. On December 27, they released their single, Joke.
F.P.B. music, videos, stats, and photos | Last.fm
https://www.last.fm/music/F.P.B.
Login; A new version of Last.fm is available, to keep everything running smoothly, please reload the site. ... FPB View wiki. F.P.B. (Fourth Price Band) was one of the first Czech punk bands of the 80s and originated from Teplice and Praha. They lasted from 1981-1985 until ...
Pru music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Pru
Pru is an artist name used by 2 different artists: a thai band and female R&B/Soul singer Pru Renfro best known for the singles 'Candles' & 'Aaroma' Pru was formed in 2001 by brothers Kamol and Krissada Sukosol Clapp, the sons of a Thai mother, Kamala Sukosol, a jazz singer and heiress of the Siam City Hotels and Resorts chain, and an American father, Terrence H. Clapp.
BGE music, videos, stats, and photos | Last.fm
https://www.last.fm/music/BGE
Listen to music from BGE like Circulation 1, Propaganda & more. Find the latest tracks, albums, and images from BGE.
Raf music, videos, stats, and photos | Last.fm
https://www.last.fm/music/Raf
Listen to music from Raf like Self Control, Infinito & more. Find the latest tracks, albums, and images from Raf.
NRA music, videos, stats, and photos | Last.fm
https://www.last.fm/music/NRA
NRA is a punk rock band from Amsterdam, The Netherlands. Their current line up is Aziz on the mic, Orange on guitar, Gwynn on bass and Mr Feaver on the drums. It's been many solid years of recording and touring for NRA since their first release in 1989, and they show no signs of slowing down at all.
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You visited the company web page Southland Marketing Inc. The company is located in the state Alabama, the city of Conyers. The legal address of our company is 1915 Old Covington Road Northeast # C Conyers, GA 30013. For more information, please call (770) 760-0627.


Organic cation transporter (OCT) 2 mediates the entry step for organic cation secretion by renal proximal tubule cells and is a site of unwanted drug-drug interactions (DDIs). But reliance on decision tree–based predictions of DDIs at OCT2 that depend on IC50 values can be suspect because they can be influenced by choice of transported substrate; for example, IC50 values for the inhibition of metformin versus MPP transport can vary by 5- to 10-fold. However, it is not clear whether the substrate dependence of a ligand interaction is common among OCT2 substrates. To address this question, we screened the inhibitory effectiveness of 20 µM concentrations of several hundred compounds against OCT2-mediated uptake of six structurally distinct substrates: MPP, metformin, N,N,N-trimethyl-2-[methyl(7-nitrobenzo[c][1,2,5]oxadiazol-4-yl)amino]ethanaminium (NBD-MTMA), TEA, cimetidine, and 4–4-dimethylaminostyryl-N-methylpyridinium (ASP). Of these, MPP transport was least sensitive to inhibition. IC50 values for 20 structurally diverse compounds confirmed this profile, with IC50 values for MPP averaging 6-fold larger than those for the other substrates. Bayesian machine-learning models of ligand-induced inhibition displayed generally good statistics after cross-validation and external testing. Applying our ASP model to a previously published large-scale screening study for inhibition of OCT2-mediated ASP transport resulted in comparable statistics, with approximately 75% of "active" inhibitors predicted correctly. The differential sensitivity of MPP transport to inhibition suggests that multiple ligands can interact simultaneously with OCT2 and supports the recommendation that MPP not be used as a test substrate for OCT2 screening. Instead, metformin appears to be a comparatively representative OCT2 substrate for both in vitro and in vivo (clinical) use.
This work was supported by the National Institute of Diabetes and Digestive and Kidney Diseases [Grant 5R01DK058251]; the National Institutes of Health National Institute of General Medical Sciences [Grant R43GM122196]; the National Heart, Lung, and Blood Institute [Grant 5T32HL07249]; and the National Institute of Environmental Health Sciences [Grant 5P30ES006694].


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text:
Appalachian Advisors Network
Appalachians for Hire
How to Cover Appalachia
Bettina Byrd-Giles
Birmingham, Jefferson County, Alabama
Photo: Quez Shipman
About Bettina:
I am a leading expert in intercultural communication, implicit bias, health equity and community development and a dynamic speaker and facilitator. After almost two decades of working at Research I universities, I shattered paradigms regarding the role of healthcare institutions in transforming the quality of life of residents in communities they serve as CEO of a clinic that served patients regardless of their ability to pay. I began a movement to improve the built environment and perceptions in a small industrial community through capacity building of stakeholders, cultural arts, social and traditional media.
What she'd like to see happen during the first 100 days of the next presidential administration:
Our region needs to attract resources and the attention of national funders. We need a strategy to address the regions poor health outcomes and overall quality of life.
Bettina's advice for journalists who want to cover Appalachia:
Keep an open mind. Don't believe everything you have previously read or watched on television. You probably have unconscious biases from watching how the region is portrayed.
Reach out to Bettina through this form:
© 2021	Appalachian Advisors Network


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I have said it before, and I'm just beating a dead horse on which everyone else has already gotten their licks. It seems that almost every action/adventure/fantasy/science fiction movie these days is based on comic book characters. Most of the films seem to follow the same formula of grand battles that barely move the plot along, villains who do next to nothing until the last few minutes of the film and all the CGI that the studio can afford. Maybe it's the fact that it's origin story after origin story, but after awhile I get the same feeling I do when I watch horror films in October: almost all of them blur together, and they could largely be the same movie.
The Hunger Games got lambasted for being too close in plot to Battle Royale, but once the story really delivered in The Hunger Games: Catching Fire a lot of those comparisons ceased. Where Battle Royale was more concerned with the immediate story with a bare minimum of framing, it became clear that The Hunger Games was more concerned with the boiling revolution against the decadent society of Panem than about the titular games themselves. The second movie unfolded like a great science fiction novel, cutting off at just the right point to where the audience was left waiting for more.


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text:
Welcome to Earthshot Now
A podcast to change the message about climate change.
At Earthshot Now we are bringing to our audience, candid and engaging chats with people from different backgrounds to talk about themselves, their life journey, their vision of the future, and how they relate to climate change or how climate change relates to them. We end each segment with a challenge to the audience to get more involved on climate issues.
Evoking the Apollo Moon Landing we want to inspire a new generation of dreamers, inventors, and everyone else to help save spaceship Earth. We can seed this revolution through people and their stories. We will be talking to sports figures, chefs, entrepreneurs, winemakers, teachers, filmmakers, policy makers and just regular people.
Mark Bernstein
Mark Bernstein, co-founder of Earthshot is your host for Earthshot Now. Mark has been a lifelong supporter of renewable energy and the environment and a pioneer of innovative approaches to environmental protection. 25 years ago, Mark was telling people cleantech is not only better for the environment, but in the long-run they will be better for the economy too. And here we are - cleantech is cheaper, better and cooler. We will chat about that and other fun topics with interesting people during these podcasts.
Chef Ron Duprat
Chef Ron Duprat has had a passion for good, healthy, locally sourced foods ever since he was a small boy growing up in Mare, Haiti. Despite a poor upbringing, he always felt at home in the kitchen observing his grandmother cook. Today, Chef Ron Duprat – celebrated restaurateur, Top Chef contender, author, humanitarian and executive chef – credits those comforting times in his grandmother's kitchen as the basis for his food philosophy: fresh, flavorful, seasonal ingredients that create mouth-watering dishes with a nod to his heritage.
Dahntay Jones
Dahntay Jones retired from the NBA in 2017 after a 13-year career that included an NBA championship with the Cleveland Cavaliers in 2016. Among other ventures since retiring from basketball Dahntay has involved himself in helping support the building of affordable housing in Florida and California with a focus on building the housing sustainability – saving energy and resources.
Bob Wyman
Bob Wyman, co-founder of Earthshot, has been an environmental attorney for 40 years and was Latham & Watkins Global Chair of the Environment, Land & Resources Department and Co-Chair of the Air Quality & Climate Change Practice. Bob has been a leader in developing market-based strategies to encourage rapid technology development and deployment.
Nikhil Jain
Nikhil cofounded ObEN with a vision to create a full AI stack to power its PAI virtual humans including speech, computer vision, and machine learning.
Before co-founding ObEN, he founded two other startups, Up and Running Software and OnGreen. Nikhil had also spent 5 years at Kaiser Permanente developing electronic medical record applications. He received his MBA from University of Southern California and has a Bachelors in Electrical Engineering.
Terry Tamminen
Terry Tamminen has been working for environmental causes for over 20 years, including climate change, renewable energy, waste to energy, among others. He served as CA EPA Secretary under Governor Schwarzenegger. During his service in state government, Terry was the architect of many groundbreaking sustainability policies, including California's landmark Global Warming Solutions Act of 2006. Terry was CEO of the Leonardo DiCaprio Foundation and is currently President and Founder of 7th Generation Advisors.
Jean Nicolas-Meo
Jean Nicolas-Meo began his career in wine in 1989, when he left Paris and moved to Burgundy to guide his family's vineyards – land that have been in his family for centuries. He lead a bold new direction and find that he enjoyed the rhythms of country life, and the challenges of running a winery, Jean-Nicolas began a period of intense modernization. He began defining his own signature style, with an emphasis on depth, refinement and impeccable balance - a style that has catapulted Meo-Camuzet to fame and earned Jean-Nicolas respect as one of the finest Pinot Noir winemakers in the world.
MK Klassen
MK Klassen began her career in humanitarian aid, working frequently in the developing world. For the past decade, MK led the development of advanced clean energy solutions for U.S. security and peacekeeping forces operating beyond secure supply lines. She recently co-founded Mana Pacific a renewable energy project development Benefit Corporation providing equitable access of sustainable, affordable energy to Pacific Island Nations and Mana Boxes supporting South African artisan women buy bringing their goods to the US market.
Johanna Sterberock
Johanna Sterberock is the author of the novels Pigs and City of Ghosts. Her short stories and essays have appeared in numerous publications, and she is a 2019 Artist Trust/Gar LaSalle Storyteller Award recipient. In Pigs four children live on an island that is the repository for all the world's garbage. Garbage arrives, the children sort it, and then they feed it to a herd of pigs. When a boy washes ashore in a barrel, the children must decide what to do with him—is he more of the world's detritus, meant to be fed to the pigs, or is he one of them? The novel explores questions about community, environmental responsibility, and the possibility of innocence.
Rob Legato
Rob Legato is a visual effects supervisor, has been nominated for five Academy Awards and won three. His first win was for his visual effects work on Titanic, his second was for his work on Hugo and his third for The Jungle Book. Rob has pioneered the use of CGI in movies and the integration of live action and CGI to create realistic action in his movies.
Coming Soon to:


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