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Case of Rabbi Melvin Teitelbaum (Charges Dismissed)
Rabbi (1976 to 1982) - Ahavath Israel Congregation, Hollywood, CA
Superior Court Judge Everett Ricks dismissed the case against attorney Melvin Teitelbaum, at the request of the District Attorney's Office, which conceded it had insufficient evidence to prosecute after being accused of sexually assaulting a 13-year-old Iranian immigrant boy.
Rabbi Teitelbaum then filed a $10-million damage suit in Los Angeles Superior Court. In his suit that the Jewish Federation Council of Greater Los Angeles, the Jewish Family Service of Los Angeles and the family that accused him conspired to have him arrested and charged.Later, confronted with evidence that placed Teitelbaum elsewhere at the time of the alleged incident, the siblings changed their story, a move the prosecutor said was "devastating" to their credibility.
Charges against rabbi dismissed (12/21/1984)
Sexual assault charges dropped against former rabbi (12/22/1984)
Rabbi wanted for child molestation and rape (07/25/1984)
Former rabbi threatened with jail over witness harassment (08/24/1984)
Rabbi Sues Over False Charges of Molestation (05/24/1985)
Charges against rabbi dismissed
By MICHAEL D. HARRIS
United Press International December 21, 1984
LOS ANGELES: A judge Friday dismissed the remaining charges in a molestation case against a former Orthodox rabbi who was accused of sexually assaulting a 13-year-old Iranian immigrant boy.
Superior Court Judge Everett Ricks dismissed the case against Melvin Teitelbaum, 34, at the request of the District Attorney's Office, which conceded it had insufficient evidence to prosecute.
One count of child molestation and a count of oral copulation with a child were thrown out of court against Teitelbaum, an attorney who was head of Ahavath Israel Congregation in Hollywood from 1976 to 1982.
Deputy District Attorney Sandy Buttitta, who made the dismissal motion, said a continuing investigation of the case cast doubt on the credibility of the alleged victim and his family and that she believed their testimony would not hold up in court.
Other charges against the former rabbi -- that he had tried to rape the youth's mother and sexually assaulted a second teenager -- were dismissed in October at a preliminary hearing.
''Hopefully, this will vindicate the rabbi,'' said his attorney, Mitchell Egers. ''Among those who knew him, there was never a question as to his innocence.''
At the preliminary hearing, the immigrant boy sullenly testified that Teitelbaum had fondled and orally copulated him at his family's apartment in September 1983.
But Egers said he could prove Teitelbaum was at a car rental agency near International Airport at the time of the alleged molestation.
Municipal Court Judge Nancy Brown, who presided over the preliminary hearing, dismissed a charge that Teitelbaum had tried in 1981 to rape the boy's mother, also an Iranian immigrant, because a three-year statute of limitations had expired. Egers maintained all the charges were fabricated.
Judge Brown also dismissed a charge that Teitelbaum molested an unrelated 12-year-old boy while the youth was preparing for his bar mitzvah because prosecutors could not locate the alleged victim to have him testify.
Sexual assault charges dropped against former rabbi
United Press International - December 22, 1984
LOS ANGELES: Sexual assault charges against a former Orthodox rabbi have been dismissed by a judge who agreed there was insufficient evidence to prove the rabbi molested a 13-year-old Iranian immigrant boy.
Superior Court Judge Everett Ricks Friday dismissed the case against Melvin Teitelbaum, 34, at the request of the District Attorney's Office.
One count of child molestation and a count of oral copulation with a child were thrown out of court against Teitelbaum, an attorney who was head of Ahavath Israel Congregation in Hollywood from 1976-1982.
Earlier charges -- that the rabbi tried to rape the youth's mother and sexually assaulted a second teenager -- were dismissed in October at a preliminary hearing.
The immigrant boy sullenly testified at the preliminary hearing that Teitelbaum had fondled and orally copulated him at his family's apartment in September 1983.
Former rabbi threatened with jail over witness harassment
United Press International - August 23, 1984
LOS ANGELES: A judge has told a former rabbi charged with child molestation and attempted rape that he will be jailed if an alleged campaign to harass witnesses and victims does not end, a prosecutor said.
''I have never seen a case where witnesses have been harassed like this,'' prosecutor Sandy Buttitta said Wednesday after meeting with the judge in the case. ''It is illegal and immoral and is a perversion of our criminal justice system.''
The defendant, Melvin Teitelbaum, 34, was rabbi of Ahavath Israel Congregation until starting a law practice in 1982, and his lawyer strongly denied the harassment allegations.
''There has never been a campaign of harassment,'' said lawyer Mitchell Egers.
''These people (the victims and witnesses in the case) are known in the community for the preposterous things they have said,'' Egers said. ''Their credibility is in question, but that is not true of the rabbi, who is known to be an honest and truthful person.''
Mrs. Buttitta said Teitelbaum's brother and other rabbis are among those who have allegedly threatened witnesses and victims in the case in an effort to have the charges dropped.
One of the victims, an Iranian woman who Teitelbaum allegedly tried to rape, has allegedly been threatened with deportation if she continues to press the case.
Recently, the mother of a 12-year-old boy Teitelbaum is charged with molesting told a newspaper that the former rabbi is innocent, claiming police had put ''words in my son's mouth.''
Teitelbaum was charged last month with trying to rape the Iranian woman and with molesting her 13-year-old son and the 12-year-old boy. He was scheduled to surrender to police July 2, but fled. He surrendered Aug. 13 and pleaded innocent.
Teitelbaum is free on $25,000 bail, which Municipal Judge Michael Tynan threatened at Wednesday's meeting to revoke if the alleged harassment does not stop.
Rabbi wanted for child molestation and rape
United Press International - July 25, 1984
LOS ANGELES: Police issued an all-points bulletin for a rabbi suspected of child molestation and attempted rape who is believed to have fled to the East Coast, officials said Wednesday.
Police were seeking Rabbi Melvin Teitelbaum, 34, an attorney and former head of the Orthodox Ahavath Israel Congregation in Hollywood from 1976 to 1982.
Teitelbaum was wanted on a felony arrest warrant charging him with three counts of sex crimes against two boys under the age of 14, and one count of assault with intent to commit rape against one boy's mother, police said.
The alleged victims were Jewish immigrants Teitelbaum was helping to gain citizenship, Detective Ralph Bennett of the Police Department's Sexually Exploited Child Unit told the Los Angeles Daily News.
Bennett said police thoroughly investigated the case before asking the district attorney's office to issue an arrest warrant July 2.
''We strongly he has left the state,'' said Bob Gore, a spokesman for the district attorney's office.
Gore declined to comment on why there was no previous announcement on the pursuit of Teitelbaum, who was treasurer of the Rabbinical Council of California.
The alleged crimes happened over a period extending from March 1, 1981, to Feb. 4, 1982. The alleged victims kept quiet because they feared they might be deported, Bennett said.
When confronted with the allegations, Teitelbaum at first agreed to surrender at police headquarters downtown. Two hours after talking to police and one hour before the scheduled surrender, the rabbi ''fired his lawyer and fled the state,'' the all-points bulletin reported.
Investigators initially requested $25,000 bail be set, but when the religious leader fled they raised the amount requested to $250,000, Gore said.
No problems had ever been reported about Teitelbaum, said Jack Azoff, president of Teitelbaum's former congregation.
''This is devastating,'' Azoff said. ''I am stunned.''
The rabbi reportedly left the small congregation because his contract expired and he subsequently set up a law practice, Azoff said.
Rabbi Sues Over False Charges of Molestation
Los Angeles Times - May 24, 1985
A Los Angeles rabbi against whom child molesting charges were filed and later dismissed filed a $10-million damage suit Thursday in Los Angeles Superior Court.
Rabbi Melvin Teitelbaum claims in his suit that the Jewish Federation Council of Greater Los Angeles, the Jewish Family Service of Los Angeles and the family that accused him conspired to have him arrested and charged.
The agencies knew, the suit asserts, that incriminating statements against Teitelbaum "emanated from a family with a multitude of emotional and family problems."
According to the suit, the family of the purported victim was in therapy with the agencies and had "an extensive history of emotional, sexual, drug, religious and family problems."
Teitelbaum also names as defendants some local news media --including The Times, the Daily News and several radio and television stations -- form reporting the charges that he contends constitute libel and slander.
Ridicule, Obloquy
Teitelbaum, 34, who is also an attorney, says in the suit that this has caused him to be the object of ridicule and obloquy and has cost him $50,000 in legal expenses to defend himself and $100,000 in lost earnings.
Charges against the rabbi, who served the Ahavath Israel Congregation in Hollywood between 1976 and 1982, were dismissed last Dec. 21 at the request of a deputy district attorney, who said new evidence led her to question the story told by his accusers.
The charges stemmed from a 1983 report by a 13-year-old boy who claimed that Teitelbaum orally copulated him during a visit when the boy's parents were not at home. The boy's sister later told authorities that her brother told her about it and that she wrote an account of his story in her diary.
Later, confronted with evidence that placed Teitelbaum elsewhere at the time of the alleged incident, the siblings changed their story, a move the prosecutor said was "devastating" to their credibility.
Posted by The Awareness Center, Inc. at 12/21/1984 11:12:00 PM No comments:
Labels: alleged sex offender, child sexual abuse, clergy sexual abuse
Case of Rabbi Isadore Trachtman
In 1983 Rabbi Isador Trachtman was accuse of cult like practices at the HaMasmid Institute, Chicago, IL. Over the years allegations were made that he manipulated women into having sexual relations with him
The Jewish Learning Center closed down, and Rabbi Trachtman moved to Israel, where he currently resides.
In 1970, Rabbi Trachtman's son was on board a air plane that was hijacked.
Chicago Rabbi Tells of Son on Hijacked Jet in Jordan Desert (09/10/1970)
All We Can Do Is Pray and Wait': Hostage's Kin (09/11/1970)
For Hostages' Kin, The Vigil Continues (09/13/1970)
Rabbi Expects Son Back Home Tonight (09/14/1970)
Hijacked Boy Greeted With Song, Dance (09/15/1970)
Rabbi hit in 'sex-slavery' suit (12/21/1984)
PEOPLE ex rel. ROSEMAN v. TRACHTMAN (12/09/1985)
Briefs (12/17/1985)
Chicago Rabbi Tells of Son on Hijacked Jet in Jordan Desert
Chicago Tribune - September 10, 1970
All We Can Do Is Pray and Wait': Hostage's Kin
For Hostages' Kin, The Vigil Continues
Rabbi Expects Son Back Home Tonight
Hijacked Boy Greeted With Song, Dance
Rabbi hit in 'sex-slavery' suit
Chicago Sun Times - December 21, 1984
Case Name: PEOPLE ex rel. ROSEMAN v. TRACHTMAN
THE PEOPLE ex rel. CYNTHIA ROSEMAN et al., by their Parents, Max Roseman et al., Plaintiffs-Appellants, v. ISADORE TRACHTMAN, Defendant-Appellee
139 Ill. App. 3d 5 *
487 N.E.2d 77 **
1985 Ill. App. LEXIS 2787 ***
93 Ill. Dec. 633 ****
Appellate Court of Illinois, First District, First Division
December 9, 1985, Filed
Prior History:
[***1]
Appeal from the Circuit Court of Cook County; the Hon. James C. Murray, Judge, presiding.
Disposition: Judgment affirmed.
Counsel: Henry L. Mason III and Chaim T. Kiffel, both of Chicago, and James Alle, of Grosse Pointe, Michigan (Sidley & Austin, of counsel), for appellants. Patrick W. O'Brien, Lynne M. Raimondo and Ann Gales, all of Mayer, Brown & Platt, of Chicago, for appellee Isadore Trachtman. Patrick T. Murphy, of Chicago, for appellees Cynthia Roseman and Phillip Burnstein.
Judges: JUSTICE CAMPBELL delivered the opinion of the court. BUCKLEY, P. J., and O'CONNOR, J., concur.
Opinion by: CAMPBELL
Opinion: [*7] [**78] [****634] Plaintiffs, Max and Rose Roseman and Naomi Burnstein, appeal from the dismissal of their two-count amended complaint filed on behalf of their adult children, Cynthia Roseman and Phillip Burnstein, respectively. Count I alleged a cause of action in habeas corpus which sought the release of Cynthia and Phillip from the alleged domination and control of defendant, Rabbi Isadore Trachtman, dean of the HaMasmid Institute, a school for the study of the Torah. Count II sought equitable relief based upon an allegation of irreparable harm to Cynthia and Phillip.
[***2] The circuit court found that it lacked jurisdiction in either habeas corpus or equity to grant the relief requested and dismissed the amended complaint without prejudice to file in either probate or mental health court. Plaintiffs appealed. For the following reasons, we affirm the judgment of the circuit court.
The record reveals the following facts pertinent to this appeal. On October 14, 1983, at an ex parte hearing, plaintiffs filed a two-count petition for writ of habeas corpus, alleging that Cynthia and Phillip were being detained and unlawfully restrained of their liberty by defendant. Plaintiffs further alleged that a writ was necessary to liberate Cynthia and Phillip from defendant's bondage so that they could receive treatment from mental health professionals. Based solely upon plaintiffs' petition, the trial court issued a writ of habeas corpus, limited to directing defendant [**79]
[****635] to produce Cynthia and Phillip in the courtroom on October 20, 1983, and to certify and return therewith the time and cause of their detainment and restraint. The court further enjoined defendant from removing Cynthia and Phillip from the jurisdiction of [***3] the court.
On October 20, 1983, defendant appeared in court with Cynthia and Phillip and filed a motion to dismiss the habeas corpus petition, alleging, inter alia, that neither Cynthia nor Phillip are restrained or deprived of their liberty by defendant. Defendant further moved to dissolve the injunction on the ground that it was issued without notice to defendant in violation of section 11 -- 102 of the Code of Civil Procedure (Ill. Rev. Stat. 1983, ch. 110, par. 11 -- 102). At the same hearing, Cynthia and Phillip moved for leave to intervene and to file their motion to dismiss. The trial court dissolved the injunction and granted Cynthia and Phillip the right to intervene and to file their motion to dismiss.
Plaintiffs then filed their answer together with a supplemental memorandum and expert affidavits of clinical psychologists, Margaret T. Singer and Jesse S. Miller, and sociologist, Richard J. Ofshe, Ph.D. Each expert stated that in his or her opinion, Cynthia and Phillip were being socially, psychologically and physically restrained of their liberty [*8] by defendant.
Thereafter, Cynthia and Phillip filed a response to which they attached their personal [***4] affidavits. In Cynthia's affidavit, she stated that:
(1) she is 31 years old;
(2) her association with defendant has been voluntary and of her own volition;
(3) she has never been beaten or punished by defendant;
(4) she has never been prevented from leaving defendant's home, where she resides;
(5) allegations of sexual contact with participants of the HaMasmid Institute are lies;
(6) she has never been prevented from visiting or communicating with her family; and
(7) the only limitations on her freedom have been caused by harassment by her parents and their agents.
In Phillip's affidavit, he stated, inter alia, that:
(1) he is 36 years old;
(2) he has been associated with defendant and the HaMasmid Institute for the past 15 years as a student and as a worker; (3) he has been free to associate with anyone and has never been restricted from visiting or communicating with his family; (4) defendant does not control or sanction his activities;
(5) within the last three years, he has earned his bachelor of arts degree from Northeastern University and has become certified in data processing; and
(6) prior to the current lawsuit, he saw his mother regularly and spoke with her bi-weekly [***5] on the telephone. In addition to their personal affidavits, Cynthia and Phillip also attached the affidavit of Dr. Martin J. Schwarz, psychiatrist, who stated that he had interviewed Cynthia and Phillip separately for approximately one hour each and, in his opinion, there was no evidence of any form of domination or mind control.
Subsequently, plaintiffs moved for leave to amend their petition and to file a supplemental memorandum and "Jane Doe" affidavit which contained a statement by an anonymous former female member of the HaMasmid Institute who allegedly had observed the relationship between defendant and Cynthia as well as between defendant and Phillip.
Following a hearing on defendant's and intervenors' motions, the trial court dismissed the cause of action, concluding that a writ of habeas corpus was not the appropriate legal remedy to try a case involving mind control. The trial court stated that the appropriate remedy, if any, is a petition under the Mental Health and Developmental Disabilities Code (Ill. Rev. Stat. 1983, ch. 91 1/2, par. 1 -- 100 et seq.) or a petition in the probate court for appointment of a guardian. Further, the court found that actual or [***6] physical restraint, which had not been alleged by plaintiffs, is necessary to invoke a court's jurisdiction in habeas corpus.
Plaintiffs then filed an amended complaint, alleging physical restraint by mental means as well as irreparable harm, and seeking, alternatively, [*9] habeas corpus or equitable relief. Defendant and intervenors moved to dismiss the amended complaint [**80] [****636] for failure to state a cause of action. Following extensive oral arguments, the trial court dismissed the amended complaint without prejudice to file in probate or mental health court. Plaintiffs' timely appeal followed.
On appeal, plaintiffs contend that the trial court erred in dismissing the amended complaint. With respect to count I, plaintiffs argue that physical restraint by mental means is a recognized ground for habeas corpus relief which, at the very least, entitles them to an evidentiary hearing.
At common law, the writ of habeas corpus was a highly prerogative form of relief, the purpose for which was to allow the speedy release of persons who were illegally deprived of their liberty. (See People ex rel. Burbank v.Irving (1982), 108 Ill. App. 3d [***7] 697, 439 N.E.2d 554.) In order to state a cause of action in habeas corpus, petitioner must allege a prima facie case of unlawful restraint. (Ill. Rev. Stat. 1983, ch. 110, par. 10 -- 102; see United States v. Ju Toy (1980), 198 U.S. 253, 49 L. Ed. 1040, 25 S. Ct. 644.) Thus, mere allegations of physical restraint, whether by mental or physical means, are insufficient unless supported by factual allegations of illegality.
It is axiomatic that when considering a motion to dismiss, all well-pleaded facts are admitted as true and all surplusage and conclusory allegations are disregarded. (See Allstate Insurance Co. v. Winnebago County Fair Association, Inc. (1985), 131 Ill. App. 3d 225, 475 N.E.2d 230; Teeple v. Hunziker (1983), 118 Ill. App. 3d 492, 454 N.E.2d 1174.) Accordingly, pleadings which state mere conclusions and characterize acts rather than set forth facts are insufficient to state a cause of action. People v. Patrick J. Gorman Consultants, Inc. (1982), 111 Ill. App. 3d 729, 444 N.E.2d 776.
In the present case, upon review of the pleadings, it is our opinion that count I of plaintiffs' amended complaint is replete with vague allegations, characterizations [***8] and conclusions and lacks the necessary well-pleaded facts to support an allegation of unlawful restraint. Plaintiffs allege that defendant has
(1) taken control of both Cynthia's and Phillip's autonomy, mind, judgment and will;
(2) impaired their cognitive functioning;
(3) imposed acts of compulsion upon Cynthia such as strict obedience, performance of menial work, sexual intercourse, denial of communication with family and friends, submission to humiliating physical and verbal discipline;
(4) regulated, controlled and isolated Phillip;
(5) required Phillip to quit his job; and (6) forced Phillip to engage in illicit and unlawful activities. We find that the aforementioned conclusory allegations are insufficient in themselves to constitute a [*10] prima facie showing of unlawful restraint, and conclude that plaintiffs have failed to state a cause of action for habeas corpus relief. Our decision is buttressed by the fact that Cynthia and Phillip expressly stated in their affidavits that they are voluntary members of the HaMasmid Institute and have not been subjected to punishment, restraint or sexual abuse by defendant. It is well established that habeas corpus [***9] relief is not applicable to an adult who voluntarily remains in his or her environment. Cf. People ex rel. Drury v. Catholic Home Bureau (1966), 34 Ill. 2d 84, 212 N.E.2d 507.
In addition, we do not find that the affidavits of the clinical psychologists and sociologist submitted by plaintiffs lend the necessary factual support to plaintiffs' allegations of mind control. By their own admission, neither Dr. Singer nor Dr. Ofshe had ever met with Cynthia or Phillip. Dr. Miller had met with Cynthia for approximately 20 minutes and with Phillip for less than five minutes on one occasion immediately following the October 20 hearing. Further, we find the "Jane Doe" affidavit equally unpersuasive on the grounds that it merely characterizes alleged conduct and sets forth vague allegations.
With respect to count II of plaintiff's complaint which sought equitable relief predicated upon irreparable harm, plaintiffs realleged the vague and conclusory allegations of count I, adding only that "Cynthia and Phillip are suffering irreparable harm of a continuing nature" and that [**81] [****637] they are without an adequate remedy at law. In our view, plaintiffs' claim of irreparable [***10] harm fails to sufficiently specify a legally cognizable harm upon which relief can be granted. (See People v. Patrick J.Gorman Consultants, Inc. (1982), 111 Ill. App. 3d 729, 444 N.E.2d 776.) Regarding the availability of an adequate remedy at law, we concur with the trial court that mental issues are more appropriately brought before the mental health court for a determination of mental competency pursuant to the Mental Health and Developmental Disabilities Code (Ill. Rev. Stat. 1983, ch. 91 1/2, par. 1 -- 100 et seq.) or before the probate court pursuant to section 11a -- 3 of the Probate Act of 1975 (Ill. Rev. Stat. 1983, ch. 110 1/2, par. 11a -- 3). While we are cognizant of plaintiffs' genuine concern for the well-being of their adult children, we find that the pleadings fail to establish a cause of action for which relief can be granted.
Accordingly, we affirm the judgment of the circuit court of Cook County.
Chicago Tribune - December 17, 1985
For a 7th appearl of the Walter Jacobson libel loss, CBS will assist Sidley * Austin with P. Cameron DeVore of Seattle, known as a 1st Amendment specialist and inventive appeals attorney who had represented the networks in moves to lift restrictions on news gathering but is not widely known as a libel expert. . . Sidley loses another as the Illinois Appeals Court affirm the dismissal of a lawsuit that birthed a notorious newspaper headline elsewhere ["Rabbi hit in 'sex-slavery' suit"] and which charged that Rabbi Isadore Trachtman held two people in "psychological bondage."
Winners are Mayer Brown & Platt's Patrick O'Brien, Lynn Ralmondo and Ann Gales, who represented the rabbi, and Public Guardian Patrick Murphy, who handled the duo whose parents claimed were held in bondage.
Labels: Chicago, clergy sexual abuse, clergy sexual abuse against adult women, cult, HaMasmid Institute, mind control, Rabbi Isadore Trachtman
Case of Rabbi Dr. Avrohom Mondrowitz
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Once Upon a One More Time
Britney Spears musical to premiere in Chicago before Broadway
In DevelopmentOnce Upon a One More Time Caitlin Huston - March 12, 2019
"Once Upon a One More Time," a musical comedy featuring the music of Britney Spears, will make its world premiere in Chicago this fall...
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The stage production will make its world premiere in Chicago this fall.
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redpajama_set_name: RedPajamaCommonCrawl


Architect Richard Rogers is perhaps best known for designing iconic structures like the Pompidou Centre in Paris, the Millennium Dome and the Maggie's Centre in London and Terminal 4 Barajas Airport, Madrid. Trained at the Architectural Association in London and Yale School of Architecture on a Fulbright Scholarship, Rogers is one of the most sought-after architects of his generation. What many people don't know is that Rogers didn't learn to read until he was 11 years old and at the age of 6 he was caned by his headmaster for failing to memorize a poem.
Born in Italy to Anglo-Italian parents in 1933, Rogers was first exposed to contemporary art and furniture by his mother, a potter, and his father, a doctor.
In addition to designing buildings all over the world, Rogers has written books including Cities for a Small Planet. In 1995, he was the first architect invited to give the prestigious BBC Reith lectures. Among his numerous awards, Rogers is the recipient of the 2007 Pritzker Architecture Prize.
Rogers has five sons and lives in London with his wife, Ruthie, who is a founder of the River Café restaurant.
When did you first discover that you were dyslexic?
The first school I went to was called Kingswood House, in Epsom, near London. I also went to a special school for a year, which saved my life because they understood my difficulties and I realized that there were other students who also had great difficulties. I then went to the Architectural Association (college level), and on to Yale.
When did you first have an inkling that you were good at architecture?
There was no particular moment of realization, but a number of factors helped to influence my decision to become an architect. Growing up I was very close to my parents – my father was a doctor and my mother a potter and artist. They instilled me with a clear understanding of how, if we build well, we can create a socially inclusive environment. This has helped to drive my work. I also drew inspiration through my cousin, Ernesto Rogers who was probably one of the most important architects in Italy in the period following the Second World War. And going to the festival of Britain in 1951 was an enlightening experience – suddenly, it showed the potential of seeing what the world could be like; a window into the future.
How was school for you academically?
It was difficult during those first years. I went to an all-male elementary school, where art was seen as something that girls did. But I was brought up in a household that had modern paintings and furniture. My parents bought a couple of Picasso prints and our friends thought that they were out of their minds. By the age of 13, I was reading avidly about culture in a broader spectrum so I knew a little about modern architecture.
Do you read for pleasure today?
Although I started to read late, I have greatly enjoyed reading throughout my life. I have very good concentration, in other words, my mind doesn't wander.
Do you think your dyslexia helps you see things in a way that other people don't?
I believe it important to have someone who believes in you and is supportive which in turn builds your confidence whether it is your parent, teacher or a friend.
I still don't draw as well as most architects. There are a lot of architects who are dyslexic, the question is: do we have a better spatial understanding, which is what I say, or is it because we can't do anything else? (laughs). I have a good spatial knowledge. Would I have lost it if I didn't have dyslexia? I know a lot of people who have good spatial knowledge who are not dyslexic.
My father was a doctor, but I know that I could never have been a doctor. At that time I could not have gotten into university. I got into architecture school partly through the back door because I was older, more determined and pulled every string I could get hold of. I was interested from an early stage in social and political issues.
Can you talk about your way of thinking?
I have a good sense of space and I am good at solving problems. Learning by rote is impossible for me as I need to understand and absorb the problem I am dealing with.
I am interested in art, science, sociology and politics, which for me is the driving force in the design of buildings and public space.
I am very interested in the design and regeneration of cities and I am involved in the politics of architecture. When the Labour party came into power, I worked closely with John Prescott and the Deputy Prime Minister and I chaired the Urban Trade Force on the state of our cities. I was Chief Advisor on Architecture and Urbanism to former Mayor Ken Livingstone and have advised the current Mayor, Boris Johnson. I have also been an advisor to the Mayor of Barcelona's Urban Strategies Council.
I am passionate about the design of cities. As to buildings, the Centre Pompidou in Paris, the very first large building I designed with Renzo Piano, is what I'm best known for and it does reflect my way of thinking.
It is a cultural center with a large public piazza in front of the building. It was designed to be a place for people of all ages, all creeds, the poor and the rich. One of my favourite buildings is Terminal 4 Barajas Airport, Madrid, which uses colors of the rainbow as a form of identification and to create both joy and orientation for users. We tend to embrace the use of color as one of the ways to strengthen the 'mood' of our buildings. Color also helps to emphasize certain rhythms, geometries and scales – you can see this clearly at Terminal 4.
You mention your mother was a huge help to you.
We worked together; I would read to her for instance, she taught me a bit of French. We had tutors. This was an advantage of being middle class as I had the opportunity to have an extended support network which is not available to those less fortunate.
Nowadays looking at my children, particularly the middle one who is the most dyslexic, one can be thankful for a more supportive system.
What advice would you give to young people with dyslexia?
Each individual child needs to seek professional help to first of all diagnose the problem and then to find out what is the best form of support. It doesn't matter what sort of learning difficulty it is; with any type of learning challenge, those affected can see specialists and do courses and nowadays allowances are made for them in exams. It is most important to build the child's confidence and tell them that it doesn't matter if they don't read until a certain age – it is not important. A lot of famous people, like Einstein, didn't read until later than usual.
Were you allowed extra time on your exams?
No, no, no! I was just called stupid. I was always behind in the class. On the whole I wasn't a difficult child. I had a group of friends, we called it a 'gang' back then. I was gregarious. People who are excluded from society tend to express themselves in ways not acceptable to society.
My tutors at Yale and the Architecture Association such as Paul Rudolph, Serge Chermayeff, Vincent Scully and Peter Smithson, but I mainly learned from my partners such as Renzo Piano, Norman Foster and John Young to name but a few. And now I write books. Fortunately, my wife is very supportive and we work closely together. She can read my handwriting better than I can and I have a wonderful secretary. With computers now, the 'spell check' can figure out my spelling, but my middle son, who is a successful designer and is also dyslexic, says that spell check doesn't understand his words, which is interesting.
Did you learn to speak a foreign language?
Yes, Italian was my first language and I came over to the UK when I was 6. Today I can speak Italian. My close friend, Renzo Piano, was Italian and we spoke Italian together. I retrieved it as an adult. I learned it by ear; I'm not good at grammar and so forth.
And I speak reasonable French having lived there for six years when Renzo and I built the Pompidou Centre.
Many projects around the world. A very large live/work/leisure development in Sydney, one of the towers for the World Trade Center site in New York and residential and commercial buildings.
Any final advice for people with dyslexia?
It is important to get a proper diagnosis as early as possible whether it is dyslexia or another learning difficulty, as it allows you to seek professional support from specialists. Families and friends are then able to work together to support one's needs.
Getting diagnosed also means you're part of a group–there's a realization that lots of people have dyslexia or know someone that has it–and it puts you in a social and historical position. There's a tremendous amount of information on the web and it brings more awareness of the challenges facing those people in their day-to-day lives.
We know an awful lot more now than we used to know about dyslexia. In the past, when the difficulty with reading arose, you hadn't got a clue how to deal with it. It left you floating, saying, "Why can't I read, when everyone else can?" Learning more about dyslexia helps you realize that there are a large number of people out there like you. I see it in my children; they have faced up to their difficulties and have become successful as a result.
John Behrens is a 42-year-old self-taught director of photography who is much too busy to blow time on boredom. He's a sucker for a good story, fiction or fact, and he loves capturing it on film. He's shot movies, feature and television documentaries, television programs, commercials, concert films, and he lives to shoot more. Working for everyone, from Metallica to Tesla Motors to Disney Pictures, and almost every television or cable network, Behrens feels his dyslexia makes constant challenge fun.
Samuel Botero knows two things for sure. One is that being Samuel Botero is not easy. The other is that you need a sense of humor in this life.
Before he became a legendary artist and illustrator of children's books, gentle Jerry Pinkney was a little boy with a lot to do. By first grade he'd already figured out two important things: he had a gift with lines when it came to creating art, but an awful lag when those same lines formed letters for language.


text:
Q: Does the zombie preview screen give any clues as to which lanes the zombies will appear on? In Plants vs Zombies, at the beginning of every level you're given a preview of which zombies occur in that level while you select your plants. Is the arrangement of zombies on that screen random, or does it correspond to the lanes in which the zombies are going to appear?

A: The distribution is random. Here are a few screenshots I just took from the iOS version, backing out to the main menu between each one:

redpajama_set_name: RedPajamaStackExchange


text:
Wednesday January 20th, 2021 12:58AM
Posted 8:31AM on Monday 28th December 2020 ( 3 weeks ago )
Class 6A notebook: Buford looks for 2nd straight title
By Jeff Hart | Video by Seth Chapman
2020 Northeast Georgia region standingsJacobs Media will broadcast Buford, Jefferson state title showdownsImproved Buford OL faces its toughest test in Lee CountyQ&A: Marist's Chadwick talks success of the program, keys to a win
We've said it before and we'll say it again: the finals showdown between Buford and Lee County for the Class 6A title in the Georgia High School Association state playoffs may be the single-best matchup of the two-day event.
Kickoff is slated for Tuesday at 7 p.m. at Georgia State Stadium. You can hear the game live on WDUN AM 550 (Click to listen live) beginning at 6:30 p.m. with the pregame.
The game is considered a toss-up as the Wolves (12-1) and Lee County (12-1) have been ranked Nos. 1 and 2 the entire season. Buford is into the championship game for the 17th time since 2001 spanning six classifications, including winning the Class 5A title in 2019. Lee County has been the top dog in Class 6A advancing to the 6A finals for the third time in four seasons.
Be sure to check back with AccessWDUN's Friday Game Night throughout the days for score updates, game stories, and video highlights of Tuesday's action. You can also check for scores and highlights on our Twitter feed: @FridayGameNight
CLASS 6A NOTEBOOK
Buford and Lee County came in ranked Nos. 1 and 2 in the classification, and along with Class 4A, will be one of two finals with the top two ranked teams advancing to play for the championship. ... Buford is looking for a state title in its 6th classification, which would add to the Wolves state record. ... After having never made it past the 2nd round in its first 47 seasons, Lee County (the 2017 and 2018 6A champions) is into the finals for the third time in four years. The Trojans are now 3-0 in semifinal games in their history. They are 2-0 all-time in the finals. ... The cream definitely rose to the top in this classification. Buford is 2nd in scoring (41.2 ppg) and No. 1 in defense (8.15 ppg) in Class 6A. Lee County is 3rd in scoring (38.7 ppg) and 3rd in defense (13.6 ppg) among teams that played 12 or more games. ... This could be one of the quickest games of the three days as both teams look to run first and are averaging over 250 yards/game on the ground.
LEE COUNTY vs. BUFORD
-- WHEN: 7 p.m.
-- WHERE: Georgia State Stadium, Atlanta
-- RADIO: WDUN AM 550
-- LEE COUNTY (12-1): Ranked No. 1 in Class 6A; No. 1 seed from Region 1; defeated Region 4 champion Westlake 35-14 in the semifinals
-- BUFORD (12-1): Ranked No. 2 in Class 6A; No. 1 seed from Region 8; defeated Valdosta 45-26 in the semifinals
-- NOTABLE: First-ever meeting between the two programs. ... This is the second straight team from Region 1 the Wolves will face and the 10th team in 2020 they are facing for the first time. ... The Trojans have been the winningest team in the classification the last four years (52-5) with now their third finals appearance in 4 seasons. They won the 2017 and 2018 titles. ... Buford has been the winningest team in the state, all classifications, since 2000 (282-23) with 11 state titles in that span. ... Buford is 10-5 in championship games since 2000, including last year's thrilling 17-14 OT win over Warner Robins to win the 5A crown. But the Wolves are just 4-3 in their last 7 finals since 2011. They are 11-7 all-time in the finals. ... The Wolves also are working on another streak. They are 10-0 in their last 10 games vs. ranked teams regardless of classification. Their last loss to a ranked team came in 2018 in a 48-24 loss to Archer. ... Lee County is 20-3 in the last 23 games against ranked teams since 2017. The Trojans are 5-1 (Lowndes County 38-13) vs. ranked teams in 2020. ... The Trojans' Caleb McDowell (157-1,258, 8 ypc, 26 TD; 96.7 pyg avg; South Carolina-signee) has been nearly unstoppable in the playoffs. Against Westlake he had 143 yards rushing and scored 3 TDs and caught a TD pass. He now has scored 16 total TDs in the 2020 playoffs. ... Lee County Sr. RB Preston Simmons (155-994, 11 TD) is just shy of breaking the 1,000-yards. McDowell and Simmons with 1 combined fumble in 312 attempts in 2020. ... The Trojans defense is led by Jr. LB Juwan Bailey, who has 62 tkls, 15 sacks, and 12 more TFL on the season. Sr. DB AJ Patrick has 7 INTs.
Associated Tags: High school football, Buford football
We've said it before and we'll say it again: the finals showdown between Buford and Lee County for the Class 6A title in the Georgia High School Association state playoffs may be the single-best matchup of the two-day event...
8:31AM ( 9 minutes ago )
8:09AM ( 31 minutes ago )
Falcons' Koo misses late FG in loss to Chiefs
Kansas City clinched the top seed in the AFC and the only playoff bye when Patrick Mahomes threw a 25-yard touchdown pass to Demarcus Robinson with just under two minutes for a 17-14 win over Atlanta on Sunday...
Former Braves' HOF pitcher Phil Niekro dies
Jefferson and Buford stormed into the Georgia High School Association state finals last week.
Lakeview Academy and Chestatee split a pair of games at the Lynn Cottrell Court in their final tune-ups before the Lanierland tournament next week...
Jacobs Media will give basketball fans across northeast Georgia the opportunity to listen and watch every game of the 61st Lanierland Tournament.
The Region 8-6A All-Region football team was released recently with members of Buford and Habersham Central taking home season-ending awards...
8:28AM ( 1 week ago )
2020 Northeast Georgia region standings
10:31AM ( 3 days from now )
9:11AM ( 23 hours ago )
Marist has been one of the most successful programs in the state for more than two decades. Marist has been one of the most successful programs in the state for more than two decades.
By Bo Wilson
11:45AM ( 1 day ago )
Lee County has ruled the Class 6A roost since 2017, winning a pair of state titles and now making its third trip to the Class 6A championship game in four years. The Trojans will take on Buford, the state's winningest program over the past 20 years, for the Class 6A title at Georgia State Stadium on Tuesday...


IDDM is a form of diabetes mellitus (DM) characterized by the dysfunction of the pancreas to produce insufficient or no insulin. This disorder is caused by autoimmune-mediated destruction of the pancreatic β-cells. Over the years, it has been observed that autoimmunity associated with IDDM involves the participation of both B and T autoreactive lymphocytes. The evidence for B cell-mediated autoimmunity is based on the well reported findings that up to 98% of IDDM patients have antibodies against one or more of their own β-cell antigens. These include: insulin ; the major of the 2 isoforms of glutamic acid decarboxylase (GAD) 65 ; two of the protein tyrosine phosphatases, insulinoma antigen-2 and insulinoma antigen-2b (IA-2 and IA-2 β) [3, 4]; the heterogeneous islet cell cytoplasmic antigens (ICAs) [5, 6]. A minority of IDDM patients also have serum antibodies to a glycosylated islet cell membrane antigen, GLIMA . Recently, autoantibodies to other new antigens of protein tyrosine phosphatases, IA-2/ICA512 and IA-2 β/phogrin, expressed by pancreatic islet cells, have been detected .
The generation of autoantibodies to islet cells can be observed for as many as 10 years prior to the onset of clinical diabetes . Despite this observation, the existence of autoantibodies is not solely sufficient to cause IDDM development. This conclusion is based on the finding that infants born of antibody positive IDDM mothers can remain free of disease despite the existence of serum autoantibodies to insulin, GAD and other islet cell antigens . On the other hand, persons with severe genetic B cell deficiency can still develop IDDM . Generally, the level of autoantibodies correlates with the state of β-cell destruction [12, 13]. As such, they can therefore serve as indicators for autoimmune diabetes. A low level of GAD-specific autoantibodies is associated with a slow breakdown of β-cell function, while a high level of autoantibodies to IA-2 together with the maturation of autoantibody responses elicited against ICAs or GAD are signs for more severe and imminent β-cell failure .
Today it is well-known that IDDM is mediated by autoreactive T cells. The most direct indication of this finding is due to the examination of biopsy tissues obtained near the time of IDDM diagnosis, which show that the islets are infiltrated with activated T cells, primarily of the CD8+ population but also, to a lesser extent, CD4+ cells and macrophages as well [15-18]. The association of IDDM with the major histocompatibility complex (MHC)-associated susceptibility gene locus, IDDM1, is also well reported . Recurrence of organ-specific autoimmunity is responsible for β-cell destruction in diabetics transplanted with a pancreatic graft donated by their discordant, non-diabetic monozygotic twins . Furthermore, IDDM is transferable to non-diabetics given bone marrow transplant donated by diabetic HLA-identical siblings, or allogeneic donors [21, 22].
Autoreactive CD4+ cells of the Th1 subset are potentially capable of directly and indirectly causing islet damage: directly via the release of cytotoxic mediators such as nitric oxide or oxygen radicals , and indirectly through the secretion of IL-2 and IFN-γ by activating autoreactive CD8+ T cells and macrophages leading to their infiltration of the islets . In this regard, characterization and quantitation of autoreactive T cells in humans are important for the development of an improved diagnosis of IDDM, and intervention strategies for arresting disease progression. However, direct detection of autoreactive T cells in IDDM is more difficult than the detection of autoantibodies. The reason is that CD4+ and CD8+ autoreactive T cells generated in the course of IDDM development are only present at very low frequencies in the circulation of subjects with recent disease onset [25, 26]. Assays dependent on in vitro expansion to allow the detection of autoreactive CD4+ T cells in the pool of peripheral blood leucocytes (PBL) of diabetics are used in most studies. When employing in vitro proliferation assays, PBL of individuals with recent onset of IDDM respond to human insulin , a spectrum of islet cell antigens [28-30], and GAD . Regarding detection, GAD-specific autoreactive T cells can be generated and cloned from peripheral T cells of recent onset IDDM patients who are carrying the disease-susceptible HLA-DR alleles . Furthermore, endogenous GAD fragments presented by IDDM-associated HLA class II molecules can be isolated . The identification of HLA-DR-restricted GAD epitopes facilitates the in vitro expansion of peripheral GAD-specific T cells from individuals with IDDM at-risk and subjects with IDDM and the subsequent demonstration of the αβTCR specificity of the autoreactive T cells against the corresponding ligand using the HLA-class II tetramer analysis procedure .
Some laboratories focus on the characterization of diabetogenic CD8+ T cells. So far, autoreactive CD8+ T cells have been detected in humans against two β-cell antigens, namely GAD 65 and preproIAPP (precursor human islet amyloid polypeptide protein), which are cosecreted with insulin in subjects recently diagnosed with IDDM. GAD 65-specific cytotoxic T cells (CTLs) carrying the disease-associated allele, HLA-A2, following in vitro expansion with a HLA-A2 binding peptide, have been generated from PBL of these individuals . A recent study describes the presence of an autoreactive CD8+ subset in the circulation of recently diagnosed patients that recognize a 9 amino acid long immunodominant epitope of preproIAPP in the context of HLA-A2 using an IFN-γ-based ELISPOT assay . The feasibility to detect and quantitate circulating autoreactive T cells directly at early disease onset can undoubtedly serve as a valuable tool for improved diagnosis of IDDM, and the development of better tolerogens which can be used to arrest IDDM onset.
Normally, IDDM is diagnosed by the time 70-90% of the patients' islet cells are already destroyed. Over the years, immunological intervention strategies have been tested for their effectiveness at the prediabetic stage of the disease to prevent its subsequent onset, or at the early stage of the disease to halt further assault on the pancreatic islets in order to allow the remaining function of the organ to be preserved. A common approach to these strategies is to target the autoreactive T cells directly. Several of these developments do work primarily in the NOD mouse model of human diabetes, some have reached the clinical trial stage. The remaining part of this review will discuss the ongoing development of these strategies and the rationale behind why they are aimed at interfering with the activity and function of autoreactive T cells believed to be involved in causing IDDM.
In view of the detection of autoreactive T cells showing specificities against islet cell antigens, intervention strategies involving the administration of soluble and formulated islet cell antigens aim at tolerizing these autoreactive T cells. For this type of approach, three antigens, namely insulin, the glutamic decarboxylase (GAD65) and heat shock protein (hsp) 60, have attracted the most attention since diabetics are known to mount immune responses against them. It has been shown in preclinical studies that administration of the native form or analogs of these antigens induce T cell mediated regulatory mechanisms capable of preventing the development of autoimmune diabetes in the NOD mice. Thus, prediabetic animals treated with insulin are less susceptible to subsequent IDDM development [37, 38]. Induction of insulin-specific regulatory T lymphocytes is protective since untreated mice that accept T cells from those administered with insulin are also protected from disease development. The protection mechanism can be attributed to the production of immuno-suppressive cytokines, such as IL-4, IL-10 and TGF-β that exert negative regulation of the diabetogenic Th1 cells .
Prediabetic NOD mice subcutaneously injected with a recombinant version of GAD65 show a cellular response dominated by the secretion of IFN-γ by the GAD65-specific Th1 cells. Interestingly, additional injection of GAD65 is able to change the response deviating towards the production of Th2 cytokines, IL-4 and IL-10 that suppress the pathogenic role mediated by the autoreactive Th1 T cells .
In 1998 a previous pilot study reported that insulin therapy is effective in preventing IDDM onset in a significant number of high-risk individuals . However, clinical trials conducted as part of the Diabetes Prevention Trial-Type 1 (DPT-1) have recently reported that both low-dose insulin administration using a similar protocol to that in the pilot study, as well as the oral intake of insulin capsules are unable to protect high-risk subjects from developing the disease . The reason for this outcome can only be postulated at the present time to be attributable to several factors, such as a difference in the study groups or insufficient administration of insulin for making a difference . It has not been shown in a study conducted by the American Diabetes Association that intervention with the GAD65 molecule (Diamyd) is able to offer clear clinical benefit. The immunogen is currently being evaluated for its effectiveness to stop the onset of LADA (latent autoimmune diabetes of adults) .
The function of a subset of pathogenic T cells can be modulated via the engagement of their αβTCR with a natural (depending on the mode of administration) or an artificial ligand in association with the respective MHC class I or II molecule. A fragment comprising the amino acid residues 9-23 of the human insulin B-chain contains a promiscuous immunodominant T cell epitope that can be recognized by CD4+ autoreactive T cells of diabetics and the NOD mice. A proportion of CD4+ T cells infiltrating the diseased islets of the diabetic mice responds to peptide B:9-23, suggesting that autoimmunity directed against this site of the human insulin B-chain significantly contributes to IDDM [45, 46]. Subcutaneous injection of pepitde B:9-23 formulated in IFA or intranasal administration of the peptide is capable of conferring protection against IDDM development in prediabetic NOD mice. The protection is associated with modulation of autoreactive T cell function as judged by their reduced capability to proliferate to peptide B:9-23 [47, 48].
More recently, an artificial version of peptide B:9-23, NBI-6024, containing alanine substitutions at positions 16 and 19 of the parent fragment has been tested for its effectiveness in arresting IDDM. The altered ligand inhibits the proliferation of B:9-23-specific autoreactive T cells obtained from the NOD mice. Furthermore, subcutaneous injection of soluble NBI-6024 is capable of protecting both prediabetic and diabetic NOD mice from disease development. The mechanism of protection has been attributed to immune-deviation based on the observation that NBI-6024 preferentially induces T cells of the vaccinated animals to produce Th2 immunosuppressive cytokines, IL-4 and IL-10 .
In tests NBI-6024 shows sufficient safety levels to reach a phase I clinical trial. It will be interesting to know whether the strategy adopted to target an immunodominant population of diabetogenic T cells may prove to be more effective in preventing IDDM development than its native parent protein. In this regard, a separate report has recommended that the soluble immunogen would be best administered at low doses to avoid/minimize the development of anaphylaxis .
In addition to its ability to modulate the function of autoreactive CD4+ T cells, the fragment comprising the amino acid residue 15-23 within NBI-6024 also appears to contain an immunodominant murine MHC class I-restricted T cell epitope. Murine islet resident diabetogenic CD8+ T cells are able to recognize peptide B:15-23 . Despite the fact that an efficacy study has not been performed with peptide B:15-23, the results of a recent study suggest that vaccination with an altered influenza virus hemagglutinin (HA) MHC class I-restricted ligand can result in modulating the activity of diabetogenic HA-specific CD8+ T cells in the prevention of diabetes onset in a transgenic mouse model. Efficacy of the therapy is associated with decreased infiltration of the pathogenic T cells to the islets, and reduced cytotoxic potential of the effector cells .
GAD65 epitopes have similarly been investigated for their capabilities to arrest IDDM in the NOD mouse. The rationale for this approach is based on the finding that spontaneous disease onset in the diabetic animal is associated with T cell reactivities directed against various epitopes of GAD65. Intervention of GAD65-specific autoreactivity at the prediabetic stage may therefore be an effective means for IDDM prevention. We already know that certain epitopes of GAD65 are capable of arresting IDDM in NOD mice. GAD65 246-266, but not GAD65 509-528 or GAD65 524-543 peptide, given in PBS to pregnant animals using the ip (intraperitoneal) route induce tolerance of the offspring in terms of resistance against diabetes development. Surprisingly, vaccination with a mixture of GAD65 509-528 and GAD65 524-543 peptides, but not a triple combination of GAD65 509-528, GAD65 524-543 and GAD65 246-266 is also effective. The reason for this outcome is unclear at the moment. Overall, more investigation is needed to establish a clearer picture of the effectiveness of GAD peptides in IDDM prevention [53-55].
Another approach to prevent neonatal NOD mice from developing IDDM involves the administration of a monoclonal antibody directed against the CD3 complex non-covalently associated with the αβTCR expressed on conventional CD4 and CD8 subsets of T cells. Upon engagement of the αβTCR with its foreign ligand, or ligand derived from self antigen (in the case of autoreactive T cells), CD3 can mediate signal transduction events leading to the activation of T cells. Thus, binding of an anti-CD3 antibody to CD3 can be expected to affect the acitvity of autoreactive T cells in causing damage to the pancreatic β-cells. Preclinical studies demonstrated that young streptozocin (STZ)-induced diabetic CD1 mice administered with the non-mitogenic [F(ab')2] fragment of a monoclonal antibody directed against the ε chain of human CD3 are prevented from developing insulitis. Protection is attributed partly to the depletion of some T cells, and partly to the antibody being capable of inducing anergy to a significant proportion of T cells as judged by their failure to produce the Th1 type of cytokines such as IL-2 and IFN-γ .
Similar to conventional T lymphocytes, full activation of autoreactive CD4+ and CD8+ T cells requires both the engagement of its αβTCR with an antigenic peptide in association with the respective MHC class I or II molecules, as well as a second signal provided by co-stimulation. A co-stimulatory signal will be generated by the interaction of CD28 molecules expressed on naïve T cells with its ligands, B7-1 (CD80) and B7-2 (CD86), presented on APCs. Of the two ligands, B7-2 plays a more dominant role in interacting with CD28 to trigger T cell activation [57, 58]. In NOD mice, the engagement of CD28 with B7-1 and B7-2 are critical for the control of spontaneous diabetes development. Animals without CD28, and B7-1 with B7-2, have a reduced number of CD4+CD25+ regulatory T cells and succumb to clinical disease faster than their wild-type counterpart .
Reagents that bind B7-1 and/or B7-2 have been evaluated for their effectiveness to block the activation of autoreactive T cells in the course of IDDM prevention in NOD mice. Indeed, prediabetic NOD mice of 2-3 weeks of age given multiple doses of an anti-B7-2 monoclonal antibody over a period of 8 weeks are protected from subsequent development of diabetes. Animals subjected to a similar regimen by injecting them with a fusion protein, CTLA-4Ig comprising the extracellular domain of CTLA-4 and the fragment of human IgG1, which binds to B7-1 and B7-2 to inhibit co-stimulation, are also protected from the onset of IDDM [60-62]. Fine analysis of the NOD mice subjected to the entire course of anti-B7-2 and CTLA-4Ig treatments identifies that the reagents inhibit the development of clinical disease rather than insulitis because animals not treated on weeks 6 to 8 (final phase of therapy) succumb to IDDM . Surprisingly, the administration of an anti-B7-1 monoclonal antibody mediates an opposite effect by triggering an accelerated onset of the disease not only in the diabetes-prone female mice, but in the normally diabetes-resistant male mice as well. Apparently, disease exacerbation is due to the presence of pancreatic T cells displaying higher expression of CD69 indicating that T cells are in a higher activated state than those found in the pancreas of animals treated with the anti-B7-2 antibody and CTLA-4Ig. The contrasting outcome obtained from these studies can be attributed to the differential expression of B7-2 and B7-1 on lymphoid cells. Given that B7-2 is expressed more rapidly than B7-1 on APCs when they become activated , blocking of B7-2 seems essential for inhibiting its interaction with CD28 to arrest diabetes development. Results obtained from studies of B7-2 knock-out NOD mice similarly show that co-stimulation in the total absence of B7-2 participation is capable of delaying insulitis development until late in the adulthood of the animals. This is associated with a redistribution of pathogenic T cells to the spleens instead of the islets of the mice. Despite the observed clinical benefit, T cell differentiation and activation without B7-2 in the B7-2 knock outs generates neuropathy characterized by severe inflammation of the peripheral nerves which precedes insulitis development . On the other hand, blocking of B7-1 expressed on activated T cells would inhibit its interaction with CTLA-4 leading to a failure in generating a regulatory signal to control IDDM development.
Overall, costimulatory pathways leading to the regulation of T cell activation and function are complex, and further in-depth investigation is required to modify them for the intervention of IDDM.
In the course of spontaneous diabetes development, NOD mice develop an immunodominant autoreactive T cell response directed against a fragment comprising the amino acid residues 437-460 of hsp 60. T cells generated against a peptide, p277, encoding this sequence of hsp60 are diabetogenic based on the observation that recipient mice adoptively transferred with the cells turn diabetic . Thus, targeting this p277-specific subset of T cells to modulate its pathological function may prove useful for arresting IDDM. The spontaneous development of diabetes in adult NOD mice is preventable by a single injection of a hsp60 peptide, p277, formulated in IFA (Incomplete Freund's Adjuvant). Efficacy is associated with a reduced infiltration of IFN-γ-secreting T cells to the islets of the p277 treated mice [66, 67]. Follow up studies have demonstrated that T cells of p277 injected NOD mice secrete disproportionate amounts of IL-4 and IL-10 to down-regulate Th1 responses elicited not only to the immunizing antigen, but to GAD65 and insulin as well. Apart from the p277 encoded epitope, another study reports the discovery of another hsp60 epitope represented by the sequence 166-185 of the protein that is effective in arresting diabetes in the NOD mice .
Peptide p277 is now being tested in a double blind phase II clinical trial. Subjects with recent onset of IDDM subcutaneously injected with two doses of the peptide maintain their insulin secretion based on C-peptide measurement, and reduce their need for exogenous insulin as compared to the placebo group .
Several antibodies directed against lymphocytic antigens have been assessed for their effectiveness in halting disease progression in NOD mice. Apart from its effectiveness in preventing IDDM onset, multiple administration of the human CD3ε chain-specific monoclonal antibody is capable of conferring long-term protection in adult NOD mice with overt diabetes. Adult NOD mice injected daily with a low-dose regimen of 5.0 μg of the antibody for 5 days are protected from accelerated IDDM development induced by cyclophosphamide. The same therapeutic application is also effective in arresting spontaneous diabetes in adult animals for a significantly long period of time. Apparently, protection is not associated with the clearance of diabetogenic CD8+ cells in the pancreatic islets of the animals . The efficacy generated by anti-CD3 treatment is mediated primarily by TGF-β that is produced by a subset of CD4+CD25- regulatory T cells, as shown in a follow-up study using a similar protocol with a high-dose regimen of 50.0 μg of the antibody . Protection provided by anti-CD3 antibody administration is also attributed to the induction of anergy in autoreactive CD8+ cells . The safety of a humanized version of the murine anti-CD3 monoclonal antibody, hOKT3γ1Ala-Ala, has been evaluated and subsequently approved for phase one trials in patients with recent-onset of IDDM . So far, the results obtained from this trial are encouraging as judged by the majority of the treated patients being able to maintain and improve their insulin secretion. Interestingly, one parameter associated with the observed efficacy is an increase in the number of CD8+ cells in the treated subjects . The regulatory/effector function of these cells remains to be investigated.
NOD mice can also be protected from spontaneous diabetes development when they are treated with the non-depleting anti-CD4 monoclonal antibody, YTS177.9 [75, 76]. The protection mechanism seems to be due to the antibody acting directly against the autoreactive T cells since mice with infiltrates of CD4+ diabetogenic T cells in their islets are also protected upon the administration of the antibody. Follow-up studies suggest that YTS177.9 binding affects autoreactive T cells by altering their capability to secrete pro-inflammatory cytokines [76, 77].
Antibodies capable of interfering with the trafficking of autoreactive mononuclear cells to the pancreatic islets have been evaluated for arresting the ongoing diabetes in the NOD mice. Migration of lymphocytes, including autoreactive T cells, requires chemoattractants and their adhesion to endothelial cells for migration from the circulation into the tissues and organs . The integrin, α4β7, is expressed on the infiltrating mononuclear cells during the process of insulitis development . A monoclonal antibody against the α4-subunit of the heterodimer, α4β7, or VCAM-1 (the ligand for the integrin), is able to block the entry of insulitis-causing mononuclear cells to the islet of the diabetic mice [80, 81].
CD43 (leucosialin), expressed as a 95-135 kDa highly glycosylated protein on T cells, is an adhesion molecule . The administration of a monoclonal antibody against CD43 is effective in preventing the onset of diabetes in newborn and adult NOD mice . Protection is attributed to the inhibition of autoreactive T cells migrating to the pancreas.
Results of earlier studies show that the administration of mono-specific antibodies against MHC class I and CD8 molecules are effective in preventing further β-cell destruction in the IDDM-prone male adult NOD/Shi/Kbe and female NOD mice, respectively [84, 85]. These observations are associated with severe T cell depletion as judged by the absence of CD8+ cells in the spleen and islets of the experimental mice. There has been no follow-up in the further development of these reagents for the prevention of IDDM in humans.
A separate approach using a fusion protein comprising a MHC class II molecule linked to a specific altered ligand has been tested preclinically for its effectiveness in preventing IDDM progression. The ligand of a chimeric construct, BDC2.5-IAg7, binds well to a subset of CD4+ diabetogenic T cells (BDC2.5). Administration of BDC2.5-IAg7 is able to confer protection to NOD.BDC2.5 TCR transgenic mice transferred with the BDC2.5 cells. Efficacy is attributed to the ability of the fusion protein to induce death and anergy to some of the BDC2.5 cells and to modulate the remaining ones to secrete more of the Th2 type of anti-inflammatory cytokines .
The advent of our understanding of IDDM has opened up a variety of opportunities for us to utilize in the search for better treatment and prevention of the disease. Improved detection of autoreactive T cells in patients with IDDM may offer better and earlier diagnosis of the disease. Improved characterization of diabetogenic T cells can be applied to the development of more effective intervention strategies to arrest the spontaneous progression of IDDM. Despite the failure of the insulin trials, results revealed by the clinical trial conducted with the human anti-CD3 specific monoclonal antibody are encouraging, and there are promising findings from other preclinical studies as well. Although not covered in this review, it needs to be mentioned here that the role of regulatory T cells in the control of IDDM is also becoming clearer, and ways to stimulate them to exert positive immunoregulation for protection against IDDM are emerging. Let us hope that some more of these strategies will make their way through to clinical assessments.


text:
This Hubot script supports all movements of Bitbucket!!

## Supporting
- Repository Events
    + Push
    + Fork
- Pullrequest Events
    + Created
    + Updated
    + Approved
    + Approval Removed
    + Merged
    + Declined
    + Comment Created
    + ~~Comment Updated~~ (Not working by Bitbucket...?)
    + Comment Deleted
- Issue Event
    + Created
    + Updated
    + Comment Created

## Installation

In your hubot directory, run:

`npm install bitbucket2slack --save`

To enable a script, add the following to the external-scripts.json

```json
["bitbucket2slack"]
```

## Configuration

### Bitbucket Add webhook

`https://bitbucket.org/{owner_name}/{repository_name}/admin/addon/admin/bitbucket-webhooks/bb-webhooks-repo-admin`

- Set following URL

`{hubot_url}/bitbucket2slack`
(exampleURL: `http:example.com:8080/bitbucket2slack`)

### Set enviroment variable HUBOT_SLACK_TOKEN

`export HUBOT_SLACK_TOKEN = {your_slack_API_token}`

### Two ways to configure the notification destination

- Get params(**priority**)
`http:example.com:8080/bitbucket2slack?destination=random`

- Enviroment variable
`export HUBOT_BITBUCKET2SLACK_DESTINATION=j_michael`

destination is {CHANNELS or PRIVATE_GROUP or DM(user_name)}

### Option to change the slack attachments colors

|Action|Type|defaultColor|
|:-----|:--:|:----------:|
|Pullrequest Create|information|LightBlue|
|Pullrequest Approved|good|Green|
|Pullrequest Approval Removed|danger|Red|
|Pullrequest Merged|good|Green|
|Pullrequest Declined|danger|Red|
|Pullrequest Comment...|warning|Orange|
|Issue ...|information|LightBlue|
|Repository Push|information|LightBlue|
|Repository Fork|information|LightBlue|

- Get params(**priority**)
`http:example.com:8080/bitbucket2slack?good_color=000000`
`http:example.com:8080/bitbucket2slack?warning_color=ff0000&danger_color=f0f`
...etc

- Enviroment variable
`export HUBOT_BITBUCKET2SLACK_GOOD_COLOR = "000"`
`export HUBOT_BITBUCKET2SLACK_INFOMATION_COLOR = "ffff00"`

The color is **not included** "#"

redpajama_set_name: RedPajamaGithub


text:
Whitty makes case for teen vaccine amid 'substantial transmission' fears
Giving teenagers the vaccine will help manage disruption to schools and mitigate against the impact of a potential winter Covid "surge", England's chief medical officer has said, as he warned of "substantial transmission" amid older pupils.
Professor Chris Whitty made the case for 12 to 15-year-olds to get the jab during a hearing of the Parliamentary education committee this afternoon.
Teenagers are due to start receiving their vaccines in schools this week after the UK's chief medical officers advised ministers to proceed.
Whitty was quizzed about the programme alongside deputy chief medical officer Professor Jonathan Van Tam and Professor Wei Shen Lim, chair of the JCVI Covid-19 sub-committee.
Also appearing were Dr Camilla Kingdon from the Royal College of Paediatrics and Child Health and Professor Keith Willett from NHS England.
The educational benefits of a move to vaccinate younger children was questioned in light of the change in August which means under-18s who are close contacts of confirmed cases no longer have to self-isolate unless they themselves test positive.
However, the move has not ended disruption to schools, with attendance figures published yesterday showing that more than 100,000 pupils were off with either a confirmed or suspected case as of last Thursday.
Modelling suggests vaccine could prevent 12m school lost days
Today, Whitty pointed to modelling released last week, which suggested the impact of vaccinating the age group could result prevent 12 million days of absence, though the lower end of the modelling suggests the saving could be closer to 110,000 days.
He said testimony from across the UK was that "in some areas, the disruption has been repeated and if there's even small amounts more, the impact of that could be very substantial, in others much less so, this is not an evening out kind of situation".
He said the modelling had predicted 12 million school says could be list "if we would have a significant surge over winter".
"Now, I do not know, you do not know, and nobody knows what kind of surges we're going to have over time and how we will have to respond to them, but I think what this does do is it provides an insurance policy to reduce – not eliminate – but to reduce significantly the impact any significant surge would have."
Whitty warns of 'substantial transmission' among teens
Whitty also explained that when looking at options, it was important to compare vaccinating a child with "a near-certainty that child will get Covid".
"Our view is firmly that people who have an infection are likely to be off school for longer than people who have a vaccination on average. Therefore since virtually any child unvaccinated is likely to get an infection at some point between 12 and 15, that is the correct comparison, not against nothing, and that's a really key point."
He also said there was "substantial transmission" happening in the 12 to 15 age group.
"In fact the age group we're talking about is the one in which the highest rate of transmission is currently occurring as far as we can tell."
Data from the latest Office for National Statistics infection survey does show that school year groups 7 to 11 had the highest level of infection.
Van Tam added that "we are not looking at a theoretical risk of children 12 to 17 becoming infected – I think it is really quite inevitable that they will be so at some point".
Advice was 'categorically' not political
The decision to press ahead with vaccines for teenagers came after the Joint Committee on Vaccination and Immunisation ruled that the margin of benefit was "considered too small" to support advice on a universal programme of vaccination.
Asked today whether the decision to recommend vaccines for 12 to 15-year-olds anyway was entirely medical, not influenced by politicians, Whitty said he could "categorically say" it was.
"There is no point in asking for professional advice…if you then take into account extraneous things"


If you're a digital camera or gadget enthusiast you are probably aware that it can be difficult to know if your SD card is actually authentic. Counterfeit memory cards have now spread throughout the marketplace. Packaging on the cards can make it difficult to distinguish a fake SD card from the real thing.
SD Insight is a free, fast and easy to use application that you use on your cell phone. Within seconds the application reads the technical details from your SD card and displays the information in an easy to understand format.
SD Insight clearly displays the SD card's manufacturer name, date of manufacture, and the product name and serial number. You can also view technical details about the internal eMMC and SDIO devices in your cell phone. Additionally, you can easily see if your SD card is a counterfeit one.
3.Open Android Emulator for PC import the SD Insight APK file from your PC Into Android Emulator to install it.
4.Installieren SD Insight APK APPS für PC.Now Sie spielen können SD Insight APK auf PC.


"Decent location with a nice apartment...."
"Great all round. Would definitely book another night...."
"My husband, daughter and I stayed in this hotel to be close to relatives in Haringey. We had a lovely warm welcome from the lady on receptio..."
"The location and the hotel room with its self catereing facilities was almost perfect and was only let down by inconsistent house keeping. I..."
Welcome to United Lodge hotel and apartments. This building oozes character and has all the amenities for a short or long stay including fully equipped kitchens and en-suite rooms. Excellently located opposite Finsbury Park, we offer the good quality self-contained accommodation .
Our rooms have character, are en-suite with fully equipped kitchenettes in some cases. Along with spacious fitted wardrobes, comfortable beds and superb WiFi throughout, we envisage your stay to be one of comfort. We are less than a 5 minute walk to Manor House (Piccadilly Line) underground station and Harringay Green Lanes (Overground) plus beautifully overlooking the Finsbury Park. Along with the numerous bus routes if you wish to travel into the city, to central London, outside London or even pop over to Europe, then this is the perfect place to be. London Victoria (20 mins), Kings Cross (15mins) to board the Eurostar, (Stanstead Airport (45 mins) and London Heathrow airport (60 mins) are all easily accessible from us. Central London is 15 minutes away from your front door and we are located on Green Lanes, with attractive local features such as Finsbury Park, Camden, and a variety of well known local shops with an eclectic array, of restaurants and cuisines on your door step.
24/10/2017 to 27/02/2026 - Guests are required to show a photo identification and the card that was used to make the booking upon check-in. We also reserve the right to pre-authorise £50.00 from a card present upon check-in The price shown is based on the occupancy and dates you have searched for. Prices and availability are subject to change based on the arrival date, number of nights and occupancy searched for. All prices are inclusive of all local taxes.


text:
GOJO CH 123: WOMEN OF DIVISION 0
"It's surprising. Are you really going down?"
A purple-haired woman with a heavy figure asked with a motherly smile.
The one she was addressing was a slender and very youthful woman with fair skin, and long black hair that was adorned at the back by a large golden ornament in the shape of a crescent moon with numerous small lines radiating outwards.
The two of them were clad in the standard attire of Captain of the Gotei 13 with the exception that there was no number on their back but rather, four flowers.
"Kirio, what brings you to my city? Yes, I plan to go down to the Seireitei. Unohana brought me some interesting information."
The Royal Palace was divided into many sub palaces. Each of them was occupied by one of the five members of the Royal Guards. They regularly visited each other.
Kirio Hikifune laughed merrily as she eyed Senjumaru up and down.
"You know very well that I am here to verify your diet. If I didn't, you guys would starve yourself to death."
Senjumaru shuddered and took a few steps back.
"Enough with your food. We don't even need to eat. In fact, I believe that we have more chances of stuffing ourselves to death because of you."
"Just because you don't need to eat doesn't mean you shouldn't. Food is life. Life is power. You need to eat to become stronger and stay healthy, right?"
Senjumaru was speechless. If anyone said this, she would simply laugh it away. Souls could feel hunger and starve when they still had an above-average Reiryoku but as soon as they surpassed a certain level, food would once again become meaningless.
But this was different when said food was cooked by Kirio Hikifune–Former captain of the 12th division. Her food could literally heal and strengthen the people who ate it.
She called it <<Food Enhancement>> .
Using the same logic she used to invent Gikongan[1], Kirio would imbue the base ingredients of the food she created by infusing the materials from the onset of growth with her Reiatsu, fundamentally changing the nature and properties.
Through the use of these ingredients, she could augment any food she made which would then empower anyone who ate it beyond any level they could ever imagine.
If it wasn't because the process was extremely demanding on her body and she could only produce a very limited amount every few years, she would have most likely tried to feed the whole Gotei 13.
Then again, it wasn't as if anyone could eat her food without the risk of exploding because of the sudden increase in power.
Shaking her head, Senjumaru observed the different tissue rolls she had in her possession and decided to discard them.
She had been lacking inspiration lately. Her creations had been stagnant and unimaginative.
This was why, when Unohana said that she could help her get great designs, she jumped at the occasion.
Of course, she had no great expectations, but she was curious. It was something Ichibe understood and that was why he didn't stop Senjumaru from going down.
If said in a graceful way, all the members of Division 0 were people who researched the truth and were full of curiosity.
In a cruder way though, they were super huge nerds who happened to have the power to destroy countries.
Loyal as they may be, but they were first and foremost researchers who affected the whole history of the Soul Society.
"I am coming with you, by the way."
Senjumaru did not seem surprised and continued to search for her sewing needles.
"I promised I wouldn't bully anyone."
"I know. I know. But admit that your track record is pretty bad. For example, how many times did you sneak into Mayuri's research center?"
Senjumaru smiled mischievously.
"My, my, sneaking in? What big words. I never sneaked into his laboratory. I simply placed my hand against the door and it opened so easily. I think Mayuri-kun should invest in better locks. Fufufu!"
"This is why I must follow you. Furthermore, I am really curious about that guy."
"Heh. It seems like everyone was affected by him."
Kirio smiled bitterly, "How could we not? His healing power and skills as a healer interest Tenjiro, the way he uses Reishi and Reitasu intrigues me, Oetsu is going mad because he doesn't understand that boy's Zanpakuto, and Ichibe is worried because of him. Now he is even making you interested in him."
Senjumaru stayed still. Indeed. Satoru Gojo was an enigma for them. All his skills defied common senses and made the research they made seem like a joke.
It was even more so because they were aware of one truth —The fact that he only entered the Soul Society 10 years ago.
"Well. If you are curious, then I guess you will be able to satiate your curiosity soon."
"Indeed. If you are ready, let's go. Let's use the Tenchuren[2]"
"Soooo~ What are we doing here again?"
Standing in a huge square, Gojo and Unohana could be seen discussing calmly.
"We are waiting. They should be down soon."
Today was the day Senjumaru was supposed to come. Gojo had already managed to smooth his way through all the obstacles and the last one was the lack of Santa costumes.
Doing Christmas without a Santa costume was blasphemy.
On the side, Gojo had contacted some seamstresses, but it was simply impossible for them to produce such a large number of clothes in such a short amount of time. If Senjumaru was half as good as Unohana said, then it would be great.
"Soon?" Looking up, Gojo frowned, "Is it that thing that is coming down like a meteor?"
As soon as Unohana finished talking, a huge pillar fell from the sky and landed brutally on the ground, raising a cloud of dust in its wake.
Using his power, Gojo stopped the dust from reaching them and easily dispersed it.
"What's that thing?"
Gojo was rather surprised. Try as he might, he could hardly see what was inside the pillar. The concentration of Reishi in that thing was so dense that nearly nothing could go through.
"It's the Tenchuren. This thing is able to pierce through the dimension wall separating the Palace from the Seireitei. From what I have heard, it's pretty comfy inside."
When the pillar finally opened, it was accompanied by a great fanfare of music as a slender black haired woman stepped down. Behind her, six mechanical hands seemingly made out of gold were each holding an instrument as they played the music.
"Hello, Unohana! It has been a while!"
Coming from behind Senjumaru eccentric entrance, Kirio waved her hand at Unohana before giving a friendly smile to Gojo,
"Hello young man. You must be Gojo-san, right? Nice to meet you."
'Who is she?'
"Oh my. Excuse me. Where are my manners? My name is Kirio Hikifune. Second officer of Division 0 and Divine General of the South. Nice to meet you!"
"Heh, so this is the rumored Gojo? What a handsome lad. The name is Senjumaru Shutara, by the way. I am the fourth officer as well as the Divine General of the North. I hope your design will not disappoint me."
Looking at the two women standing in front of him, Gojo could only give a stiff smile because of what he was seeing through the Six eyes.
'Haha~What a bunch of monsters.'
He had tried to overestimate the Royal Guards as much as possible, but it seemed that he had still been quite short of the reality.
"Nice to meet you too. My name is Satoru Gojo. I hope we will have great cooperation."
'Well. It doesn't matter how strong they are—since I am stronger.'
This was the first meeting between Gojo and the members of the royal guards.
[1]: Artificial Soul Pill. They house the Gikon (Artificial souls) that shinigami use when they are on earth during their mission and have to use Gigai (Artificial bodies)
[2]: Heavenly Pillar Palanquin
(AN: Honestly, Division 0 is broken in another way aside from power. It's their ability to incredibly boost anyone in a short period of time. I really don't understand why they never used their skills to boost all captains and vice-captains. Or perhaps they did and it was not mentioned?)
GOJO CH 122: TOKINADA TSUNAYASHIRO
GOJO CH 124: DETHRONED KING
Categories: GOJO: A SORCERER IN THE SOUL SOCIETY
Tags: GOJO
Anonymous · 2022-03-06 at 4:39 AM
Nice chapter
So he's already reached that height of strength
They didn't boost anyone because they can't. They are forbidden from interfering with anything that's happening in Seretei unless enemy go up to the Palace
And it's admittedly incredibly dumb.
Which show that Kubo indeed created the division 0 somewhere between the end of Espada arc or during Fullbringer arc.
So he had to find an excuse the explain why those super duper powerful guys didn't appear when everything was going to hell
GOJO CH 148: FIGHTING UNOHANA (2)
Down below is the link towards the chapter on my new site. Give a try and give me opinion here or on the new site or on Discord (better on discord honestly) CH 148: FIGHTING Read more…
[Earth; Karakura Town] "Ken-chan, are you worried?" Lying down on the floor next to Zaraki, Yachiru was holding a picture book when she asked suddenly. She could feel that Zaraki had become quite restless and Read more…
GOJO CH 146: PROMISED BATTLE
*Bam* "Gin Ichimaru, in the light of your crimes and the fact that you may have been indoctrinated as a child by the criminal Sosuke Aizen, you are hereby sentenced to 2000 years of imprisonment Read more…


text:
Bloc Party's Kele Okereke announces new album with single 'Streets Been Talkin''
@@FarOutMag
Thu 6th Jul 2017 10.09 BST
Kele Okereke has announced his new album Fatherland, set for release October 6 via BMG.
Fatherland sees Okereke challenge himself musically in what he's described as the most adventurous chapter of his ever-evolving career, and includes duets with Olly Alexander of Years & Years and Corinne Bailey Rae. This is the Bloc Party frontman's third solo album, but first under his full name, and a significant sonic departure from adrenalised electronics of his previous two solo records, The Boxer and Trick.
'Streets Been Talkin" from the forthcoming album is available now to stream and download. The track "was one of the first tracks I wrote for the album," says Kele. "It's a bittersweet ode to romance and the passing of time."


text:
'Occupy' protests held around the world
From Tokyo to London, protesters worldwide join day of solidarity with New York's 'Occupy Wall Street' movement.
New York's 'Occupy Wall Street' movement goes global in several dozens of cities from Asia to Latin America [Reuters]
Protesters worldwide have joined the "Occupy Wall Street" movement in a cry of rage against bankers, financiers and politicians they accuse of ruining global economies and condemning millions to poverty and hardship through greed.
Dozens of cities across the world - from Tokyo to Alaska via London, Frankfurt and Washington - are holding demonstrations on Saturday, in a show of solidarity with the rallies that began last month in downtown New York.
"On October 15th people from all over the world will take to the streets and squares ... to initiate the global change we want," proclaimed the website United for #GlobalChange.
"We will peacefully demonstrate, talk and organize until we make it happen. It's time for us to unite; it's time for them to listen."
Melbourne, Australia's second-largest city, saw the day's first demonstration, when at least 1,000 people, including children, gathered at City Square.
"We face similar problems with our democracy here in Victoria and Australia as people face in most other developed nations," the Occupy Melbourne website said. "Our democracy is unwell."
In Sydney, about 2,000 protesters including representatives of Aboriginal groups, communists and trade unionists, protested outside the central Reserve Bank of Australia, at Martin Place in the central business district time.
'Occupy Asia'
Demonstrations of various sizes took place in Asia, namely in Japan's Tokyo, the Philippines' Manila, Taiwan's Taipei, South Korea's Seoul and China's Hong Kong.
Several protests and rallies were held simultaneously in various locations at the Japanese capital.
Hundreds of demonstrators marched to the headquarters of Tokyo Electric Power Co. and the Ministry of Economy, Trade and Industry to show dissatisfaction over the handling of the nuclear disaster triggered by the March 11 earthquake and tsunami.
Despite heavy rains in Seoul, the South Korean capital, members of more than 30 civic groups congregated outside the Financial Services Commission in Yeouido, the city's financial district.
Activists wearing Guy Fawkes masks staged performances to express their frustration with the growing income gap in Seoul, and chanted "We are the 99 per cent" - one of the seminal slogans of the Wall Street movement.
In Manila, about 100 members of Bayan, an alliance of various left-wing groups in the Philippines, marched to the US embassy, waving banners that read: "Down with US imperialism" and "Philippines not for sale", broadcaster APTN reported.
They took Saturday's occupy protest to voice support for the New York movement and to express their cricism of US troop presence in the country's south.
One man was seen carrying a placard that read: "Genuine people's democracy lives in the streets."
In Hong Kong, more than 200 people gathered at Exchange Square Podium in the city's central shopping and business district.
Some pitched tents to stay overnight at the site while others later migrated to the HSBC building nearby.
Taipei, the Taiwanese capital, saw a smaller turnout of near 100 people than the expected 1,500, at the city's landmark skyscraper Taipei 101, home to the Taiwan Stock Exchange.
#GlobalChange
The Occupy South Africa website announced "Operation Ubuntu", a Nguni word used to describe unity for a common purpose through an African worldview that people can only find fulfilment through interacting with other peoples.
Protests are scheduled in the country's major cities of Capetown, East London, Durban and Johannesburg for later on Saturday.
Greek protesters aligned with Spain's "Indignant" movement called an anti-austerity rally in Athens' Syntagma square, the focal point of many demonstrations during Greece's financial meltdown.
Cath Turner reports on Wall Street activists' defiance
In Germany, the financial centre of Frankfurt and the European Central Bank was expected to be a focus of marches called by the Real Democracy Now group.
"What is happening in Greece now is the nightmare waiting other countries in the future," Real Democracy said in a statement.
"Solidarity is people's weapon."
In Britain, about 4,000 people have signalled their intent to attend a peaceful demonstration that will start at noon today in the City of London -- a leading international financial centre -- under the banner "Occupy the Stock Exchange", according to organisers.
In the United States, the founding "Occupation Wall Street" movement has urged more people and cities to join them on Saturday.
There have also been calls for occupations similar to that in Manhattan's Zuccotti Park to take place in dozens of US cities.
In Houston, Texas, protesters plan to tap into anger at big oil companies.
Alert for violence
The protests are billed as peaceful. But in a sign of what may happen, a group of students stormed Goldman Sachs' offices in the Italian city of Milan on Friday.
The students managed to break into the hall of the Goldman Sachs building in the heart of Milan's financial district.
The protests were quickly dispersed but red graffiti was daubed on its walls expressing anger at Silvio Berlusconi, the Italian prime minister, and saying "Give us money".
Demonstrators also hurled eggs at the headquarters of UniCredit, Italy's biggest bank.
Italian police were on alert for thousands to march in Rome against austerity measures planned by Berlusconi's government.


The Earth, wind, and fire concept (EWF) applies the use sunlight, wind, and falling water to ventilate and cool down the rooms, and to supply warm water. Natural processes are used to ventilate the rooms: air is moved through falling water drops and through sunlight, warming up air in a vertical column. Two 'solar chimneys', constructed out of glass and with a backside of black solar panels, harvest the necessary warmth to move the air upwards. A heat exchanger transfers the warmth into a water circuit. A central heat pump further heats the water, to heat the rooms individually and to supply hot water for the showers. Learn more about EWF in this article or read the full dissertation here.
The Breeze Hotel in Amsterdam is initiated by Amstelius/Dutch Green Company in collaboration with Borghese Real Estate, and Bronconsult, the firm of Ben Bronsema. Read more about the hotel here.


If you are looking for a Thanksgiving dinner with all the fixings but none of the prep, clean-up, and endless hours in the kitchen—then you should head to one of these incredible Portland restaurants. Don't forget to call ahead and make those reservations! You can have your pick of restaurants offering prix fixe dinners, a la carte menus, and traditional bountiful buffets. We found the classic American style dishes, vegetarian fare, and flavorful International options. These restaurants fill up fast so make sure to call ahead and make your reservation. Read on to find out more.
Hubers Café has been a staple in Portland since they've opened in 1879. Over 100 years later they are still known for their delicious turkey and majestic décor. When you walk into the establishment you are taken back to another time. This place is so popular for Thanksgiving that people start reserving a year in advance. Stop everything now and call.
The Country Cat Dinnerhouse & Bar in Montavilla is back again with another incredible Thanksgiving feast! This year they will be serving a four-course classic prix-fixe Thanksgiving dinner on November 22. Thanksgiving hours are 2-8p.m. and they are currently taking reservations for parties of 2 or more, up to 10 people. You don't want to miss this yumminess! Check back soon for the menu. You can expect to pay $60 per person which does not include beverages or gratuity. Kids' under 10 will have a separate menu and pay $15 per person.
On Thanksgiving day head down to the waterfront for the perfect buffet with the perfect setting! The Portland Spirit is once again offering their Holiday Buffet Cruise which allows you to sit back, relax, eat, and cruise down the river! You'll have views of the city and the historic Milwaukie waterfront while others do all the cooking. You'll get a private table where you can enjoy live piano music, singing servers, a 2 ½ hour cruise, hot tea, and a holiday buffet with dessert. You pay $70 per person for the whole experience. Kids between the ages of 1 and 12 pay $35 per person. There are two cruise options that day. The first cruise boards at 11 a.m. and returns at 2 p.m. while the second ship boards at 4 p.m. returning at 7 p.m. Head over to their website to view their buffet menu.
Looking for something not quite so traditional? The beloved Peruvian restaurant Andina is offering a Peruvian twist on their Thanksgiving meal. They have a 3 course prix-fix menu with splashes of lots of Peruvian influenced recipes and spices. Kids pay ½ price and get half the food.
On Thanksgiving Day from Noon to 8 p.m. you can bring the whole family to Bread and Ink for a four course prix-fix lunch or dinner. You can select your choice of appetizer, soup or salad, one of any five entrees with sides, and one of their three decadent desserts. They are not accepting online reservations so make sure to call ahead.
If you join McMenamins this year you'll have to do ZERO cooking! The buffet ranges from classics like roasted turkey and pumpkin pies to Cranberry Fireside Port Relish and an assortment of fabulous desserts. With LOTS more in between! The bar will be open so you can order the perfect ale to accompany your meal. Load up your plate and enjoy tasty food alongside those you love the most. Now that's something to be thankful for.
Call ahead and make your reservation for anytime between 1 p.m. and 7 p.m.


Crowdfunding tip No. 1: Get Mark Zuckerberg's attention. If you do, chances are you'll blow past your crowdfunding goal. Just ask Code.org.
Code.org, a nonprofit that aims to bring computer science education to schools through online tutorials and teacher training, launched a crowdfunding campaign on Indiegogo in October with the goal of raising $5 million.
As of today, the campaign has raised almost $3 million, becoming the most funded project in Indiegogo history. The previous record was held by Stone Brewing Company at $2.5 million.
The campaign seeks to introduce 100 million students to an Hour of Code -- or one hour of computer coding training -- as a tie-in with Computer Science Education Week, which runs from Dec. 8 to Dec. 14.
Mark Zuckerberg, the Silicon Valley titan who founded Facebook, has donated $1 million to the cause. On top of that, a team of Code.org donors have comitting to match dollar-for-dollar every dollar donated. The collective of donors includes Microsoft, Google, Salesforce.com, Microsoft-founder Bill Gates, and Reid Hoffman, the co-founder of LinkedIn.
Launched in 2013 by founders Ali and Hadi Partovi, Code.org offers courses in more than 30 languages and its intro class has been used by more than 1.5 million students worldwide.
Have a looksee at the videos below to learn how the money raised will be used to benefit children in classrooms around the world.