Functional evaluation of the P681H mutation on the proteolytic activation the SARS-CoV-2 variant B.1.1.7 (Alpha) spike
Identification of druggable host targets needed for SARS-CoV-2 infection by combined pharmacological evaluation and cellular network directed prioritization both in vitro and in vivo.
Somatic uniparental disomy mitigates the most damaging EFL1 allele combination in Shwachman-Diamond syndrome Genome-wide analysis of the apple family 1 glycosyltransferases identified a flavonoid-modifying UGT, MdUGT83L3, which is targeted by MdMYB88 and contributes to stress adaptation Modifying root/shoot ratios improves root water influxes in wheat under drought stress Second Heart Field-derived Cells Contribute to Angiotensin II-mediated Ascending Aortopathies Autophagosomes fuse to phagosomes and facilitate the degradation of apoptotic cells in Caenorhabditis elegans Potential autoimmunity resulting from molecular mimicry between SARS-CoV-2 Spike and human proteins TeamTree analysis: a new approach to evaluate scientific production 3D Reconstructions of Mouse Skeletal Muscle Reveal a Decrease in the MICOS Complex and Altered Mitochondrial Networks Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition ZIKV disrupts placental ultrastructure and drug transporter expression in mice Temperature drives variation in flying insect biomass across a German malaise trap network The emergence of highly fit SARS-CoV-2 variants accelerated by epistasis and caused by recombination Macroscopic control of synchronous electrical signaling with chemically-excited gene expression TAK1 blockade as a therapy for retinal neovascularization Differences in gait stability and acceleration characteristics between healthy young and older females HOXB7 induces STAT3-mediated transformation and lung metastasis in an immortalized mammary gland NMuMG cells First detection of herpesvirus and frequency of mycoplasma infection in free-ranging Hermann s tortoises (Testudo hermanni), and in potential pet vectors Risky choice: probability weighting explains Independence Axiom violations in monkeys Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption Precartilage condensation during limb skeletogenesis occurs by tissue phase separation controlled by a bistable cell-state switch with suppressed oscillatory dynamics Construction of a new chromosome-scale, long-read reference genome assembly for the Syrian hamster, Mesocricetus auratus The compound of baicalein, wogonin, and oroxylin-A inhibiting EMT in A549 cell line via PI3K/AKT-TWIST1-glycolysis pathway Emergent dynamics of a three-node regulatory network explain phenotypic switching and heterogeneity: a case study of Th1/Th2/Th17 cell differentiation Direct neural evidence for the contrastive roles of the complementary learning systems in adult acquisition of native vocabulary