A single domain shark antibody targeting the transferrin receptor 1 delivers a TrkB agonist antibody across the blood brain barrier to provide full neuroprotection in a mouse model of Parkinson's Disease
The Digital Brain Bank, an open access platform for post-mortem datasets
Generalization of Cortical MOSTest Genome-Wide Associations Within and Across Samples Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic andtargetable tissue states Decreased cell stiffness facilitates detachment and migration of breast cancer cells in 3D collagen matrices: An exploratory study Emergent dynamics of a three-node regulatory network explain phenotypic switching and heterogeneity: a case study of Th1/Th2/Th17 cell differentiation Efficient and Economical Targeted Insertion in Plant Genomes via Protoplast Regeneration Embryo development in Carica papaya Linn. An estimate of the deepest branches of the tree of life from ancient vertically-evolving genes Barbary ground squirrels do not have a sentinel system but instead synchronise vigilance HSP90 modulates T2R bitter taste receptor nitric oxide production and innate immune responses in human airway epithelial cells and macrophages Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition SARS-CoV-2 spike-glycoprotein processing at S1/S2 and S2' and shedding of the ACE2 viral receptor: roles of Furin and TMPRSS2 and implications for viral infectivity and cell-to-cell fusion Physiological Substrates and Ontogeny-Specific Expression of the Ubiquitin Ligases MARCH1 and MARCH8 Metabolic reconstitution by a gnotobiotic microbiota varies over the circadian cycle Feed efficiency of lactating Holstein cows was not as repeatable across diets as within diet over subsequent lactation stages α-catenin links integrin adhesions to F-actin to regulate ECM mechanosensing and rigidity-dependence Loss of Resf1 reduces the efficiency of embryonic stem cell self-renewal and germline entry 3CAC: improving the classification of phages and plasmids in metagenomic assemblies using assembly graphs Bacterial H-NS contacts DNA at the same irregularly spaced sites in both bridged and hemi-sequestered linear filaments Analysis of science journalism reveals gender and regional disparities in coverage Spatial organization of chromosomes leads to heterogeneous chromatin motion and drives the liquid- or gel-like dynamical behavior of chromatin Intervene or wait? A model evaluating the timing of intervention in conservation conflicts adaptive management under uncertainty. Cellular feedback to organotelluranes displays modulation of antioxidant proteins gene expression Differences in gait stability and acceleration characteristics between healthy young and older females Development and Characterization of PAR-Trackers: New Tools for Detecting Poly(ADP-ribose) In Vitro and In Vivo