Discovery of pan-ErbB inhibitors protecting from SARS-CoV-2 replication, inflammation, and lung injury by a drug repurposing screen
Nelfinavir markedly improves lung pathology in SARS-CoV-2-infected Syrian hamsters despite lack of an antiviral effect
Inference of an integrative, executable network for Rheumatoid Arthritis combining data-driven machine learning approaches and a state-of-the-art mechanistic disease map Neuroinvasion and neurotropism by SARS-CoV-2 variants in the K18-hACE2 mouse Diverse wMel variants of Wolbachia pipientis differentially rescue fertility and cytological defects of the bag of marbles partial loss of function mutation in Drosophila melanogaster The role of Kabuki Syndrome genes KMT2D and KDM6A in development: Analysis in Human sequencing data and compared to mice and zebrafish Feed efficiency of lactating Holstein cows was not as repeatable across diets as within diet over subsequent lactation stages Multi-omics-based label-free metabolic flux inference reveals obesity-associated dysregulatory mechanisms in liver glucose metabolism Neuronal Activation of the Gastrointestinal Tract Shapes the Gut Environment in Mice POPULATION GENOMIC ANALYSIS OF CRYPTOCOCCUS BRAZILIAN ISOLATES REVEALS AN AFRICAN TYPE SUBCLADE DISTRIBUTION HOXB7 induces STAT3-mediated transformation and lung metastasis in an immortalized mammary gland NMuMG cells Quantifying the Morphology and Mechanisms of Cancer Progression in 3D in-vitro environments: Integrating Experiments and Multiscale Models Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition Design, Mutate, Screen: High-throughput creation of genetic clocks with different period-amplitude characteristics Medium-throughput zebrafish optogenetic platform identifies deficits in subsequent neural activity following brief early exposure to cannabidiol and Δ-9-tetrahydrocannabinol VIP plasma levels associate with survival in severe COVID-19 patients, correlating with protective effects in SARS-CoV-2-infected cells. We get by with a little help from our friends: diversity begets diversity through shared adaptive genetic variation Deficiency of gluconeogenic enzyme PCK1 promotes murine NASH progression and fibrosis by activation PI3K/AKT/PDGF axis Bifurcating Neurons In The Anterior Thalamic Nuclei "Adopt a Microorganism" methodology enhances the discourse richness of high school students in both hybrid learning and remote education The pathogen-encoded signaling receptor Tir exploits host-like intrinsic disorder to assist infection EGFR inhibition leads to enhanced desmosome assembly and cohesion in cardiomyocytes Action at a distance: Defects in division plane positioning in the root meristematic zone affect cell organization in the differentiation zone Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis Plant-host shift, spatial persistence, and the viability of an invasive insect population Flexible control of Pavlovian-instrumental transfer based on expected reward value