Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold.
Protein scaffold-based multimerization of soluble ACE2 efficiently blocks SARS-CoV-2 infection in vitro and in vivo
"Neighbourhood watch" model: embryonic epiblast cells assess positional information in relation to their neighbours Stimulus manipulations permit activation of fiber subpopulations in the mouse and rat vagus Trade-offs in biosensor optimization for dynamic pathway engineering Cellular feedback to organotelluranes displays modulation of antioxidant proteins gene expression Analysis of science journalism reveals gender and regional disparities in coverage Interactions between sensory prediction error and task error during implicit motor learning Swine H1N1 influenza virus variants with enhanced polymerase activity and HA stability promote airborne transmission in ferrets Propelling and perturbing appendages together facilitate strenuous ground self-righting First detection of herpesvirus and prevalence of mycoplasma infection in free-ranging Hermann s tortoises (Testudo hermanni), and in potential pet vectors Joint interactions with humans may pose a higher risk of zoonotic outbreaks than interactions with conspecifics among wildlife populations at human-wildlife interfaces Fatal COVID-19 and non-COVID-19 Acute Respiratory Distress Syndrome is Associated with Incomplete Alveolar Type 1 Epithelial Cell Differentiation from the Transitional State Without Fibrosis Embryo development in Carica papaya Linn. Inhibition of microbial deconjugation of micellar bile acids protects against intestinal permeability and liver injury Phylogenetic analysis of molecular pathways in Tregs Suppressor Function Structural basis for targeting the human T-cell leukemia virus Tax oncoprotein and syntenin-1 interaction using a small molecule Tissue homeostasis and adaptation to immune challenge resolved by fibroblast network mechanics Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition The nucleus bypasses obstacles by deforming like a drop with surface tension mediated by lamin A/C Using machine learning to design adeno-associated virus capsids with high likelihood of viral assembly A Positive Correlation between Bacterial GC Content and Growth Temperature SIX1 Reprograms Myogenic Transcription Factors to Maintain the Rhabdomyosarcoma undifferentiated state The polyglutamine amyloid nucleus in living cells is a monomer with competing dimensions of order Activation of the type 3 secretion system of enteropathogenic E. coli leads to remodeling of its membrane composition The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance