Identification of Piperlongumine (PL) as a new E3 ligase ligand to induce targeted protein degradation
A platform of patient-derived microtumors identifies individual treatment responses and therapeutic vulnerabilities in ovarian cancer.
GPI-anchored FGF directs cytoneme-mediated bidirectional signaling to self-regulate tissue-specific dispersion Non-Newtonian Blood Rheology Impacts Left Atrial Stasis in Patient-Specific Simulations Regulatory perturbations of ribosome allocation optimize the growth proteome with a trade-off in adaptation capacity A Human-Immune-System (HIS) humanized mouse model (DRAGA: HLA-A2. HLA-DR4. Rag1 KO.IL-2Rγc KO. NOD) for COVID-19 Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition RNA polymerase II is recruited to DNA double-strand breaks for dilncRNA transcription in Drosophila Conformity leading self-organised rescue from a suboptimal decision-making bias Neural support for contributions of utility and narrative processing of evidence in juror decision making Alpha-Frag: a deep neural network for fragment presence prediction improves peptide identification Muscle activation strategies of the vastus lateralis according to sex Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation Interplay between receptor binding, immune escape and protein stability determines the natural selection of SARS-CoV-2 variants A novel two-generation approach to the population dynamics of gregarious parasitoids Citation needed? Wikipedia and the COVID-19 pandemic Long-term conservation effects of protected areas in stochastic population dynamics Earliest photic zone niches probed by ancestral microbial rhodopsins POPULATION GENOMIC ANALYSIS OF CRYPTOCOCCUS BRAZILIAN ISOLATES REVEALS AN AFRICAN TYPE SUBCLADE DISTRIBUTION Robust retrieval of data stored in DNA by de Bruijn graph-based de novo strand assembly Somatic uniparental disomy mitigates the most damaging EFL1 allele combination in Shwachman-Diamond syndrome A small molecule that promotes cellular senescence prevents fibrogenesis and tumorigenesis in vitro Anchorage by seed mucilage prevents seed dislodgement in high surface flow: a mechanistic investigation SkewDB: A comprehensive database of GC and 10 other skews for over 28,000 chromosomes and plasmids Tackling polypharmacology of kinase inhibitors and selecting chemical kinase probes by transcription factor activity profiling. Structural insights into p300 regulation and acetylation-dependent genome organisation