Nelfinavir induces cytotoxicity towards high-grade serous ovarian cancer cells, involving induction of the unfolded protein response, modulation of protein synthesis, DNA damage, lysosomal impairment, and potentiation of toxicity caused by proteasome inhibition
Deep learning: step forward to high-resolution in vivo shortwave infrared imaging
P2X2 receptor subunit interfaces are missense variant hotspots where mutations tend to increase apparent ATP affinity Chromatin-contact atlas reveals disorder-mediated protein interactions and moonlighting chromatin-associated RBPs Physiology and ecology together regulate host and vector importance for Ross River virus and other vector-borne diseases Higher-order effects, continuous species interactions, and trait evolution shape microbial spatial dynamics Immediate and sustained effects of cobalt and zinc-containing pigments on macrophages Population differences in the length and early-life dynamics of telomeres among European pied flycatchers Orchestrated Excitatory and Inhibitory Learning Rules Lead to the Unsupervised Emergence of Self-sustained and Inhibition-stabilized Dynamics Venomics and antivenomics of Indian spectacled cobra (Naja naja) from the Western Ghats Large Bi-ethnic Study of Plasma Proteome Leads to Comprehensive Mapping of cis-pQTL and Models for Proteome-wide Association Studies A multivariate view of cognitive performance reveals positive correlation in the Trinidadian Guppy (Poecilia reticulata) Creatine transporter deficient rat model show motor dysfunction, cerebellar alterations and muscle creatine deficiency without muscle atrophy Improving epigenetic clock performance and interpretation with deep learning Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition A novel 5 prime DNA binding site in RFC facilitates PCNA loading for gap DNA repair Quantifying the Morphology and Mechanisms of Cancer Progression in 3D in-vitro environments: Integrating Experiments and Multiscale Models Naming Human Diseases: Ethical Principles of Curating Exclusive Substitute for Inopportune Nosology Only 2 of 12 now-deleted genes of 19 identified and predicted Myb family DNA binding proteins are directly involved in rice Magnaporthe oryzae pathogenicity Ribosome actuator via the SpoT/ppGpp pathway to mitigate gene overexpression burden METHYLOME DYNAMICS UPON PROTEASOME INHIBITION BY THE PSEUDOMONAS VIRULENCE FACTOR SYRINGOLIN A A chemical screen based on an interruption of zebrafish gastrulation identifies the HTR2C inhibitor Pizotifen as a suppressor of EMT-mediated metastasis Prediction of survival after partial hepatectomy using a physiologically based pharmacokinetic model of indocyanine green liver function tests Parallel introgression, not recurrent emergence, explains apparent elevational ecotypes of polyploid Himalayan snowtrout Mitochondrial genomes of two parasitic Cuscuta species lack clear evidence of horizontal gene transfer and retain unusually fragmented ccmFC genes Estimation of differential cell cycle kinetics in higher plant root meristem with cellular fate and positional resolution.