Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence
Weakly deleterious natural genetic variation greatly amplifies probability of resistance in multiplexed gene drive systems
Once-daily feeding is associated with better health in companion dogs: Results from the Dog Aging Project Active feature selection discovers minimal gene sets for classifying cell types and disease states with single-cell mRNA-seq data Hydrothermal Synthesis of Clove Bud-Derived Multifunctional Carbon Dots Passivated with PVP- Antioxidant, Catalysis, and Bioimaging Applications Tree invasions threaten the conservation potential and sustainability of U.S.rangelands Synergy of chemotherapy and macrophage depletion leads to B cell-mediated T cell memory activation and durable triple negative breast cancer regression IRGM/Irgm1 Aggravates Progression of Atherosclerosis by Inducing Macrophage Apoptosis through the MAPK Signaling Pathway Contrasting resistance and resilience to light variation of the coupled oxic and anoxic componentsof an experimental microbial ecosystem Flavobacterium johnsoniae Tyrosine Ammonia Lyase (FjTAL) in-silico Structure Prediction and Molecular Docking to L-Tyrosine, p-Coumaric Acid (pHCA) and Caffeic Acid Propionate ameliorates diabetes-induced neurological dysfunction through regulating the PI3K/Akt/eNOS signaling pathway Multivariate genome-wide association study on tissue-sensitive diffusion metrics identifies key molecular pathways for axonal growth, synaptogenesis, and astrocyte-mediated neuroinflammation Illuminating the plant transposon insertion landscape in real time using Cas9-targeted Nanopore sequencing and a novel pipeline Onset and kinetics of B cell polarization depend on substrate mechanics and antigen concentration Network Inference from Perturbation Time Course Data Regulation of ammonium acquisition and use in Oryza longistaminata ramets under nitrogen source heterogeneity Sperm Histone H3 Lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition "Adopt a Microorganism" methodology enhances the discourse richness of high school students in both hybrid learning and remote education A novel method for producing functionalized vesicles that efficiently deliver oligonucleotides in vitro in cancer cells and in vivo in mice Morphology of immatures of the thelytokous ant, Monomorium triviale Wheeler (Formicidae: Myrmicinae: Solenopsidini) with descriptions of the extraordinary last-instar queen larvae SufB intein splicing in Mycobacterium tuberculosis is influenced by two remote conserved N-extein Histidines A model of working memory for latent representations Adaptive anti-tumor immunity is orchestrated by a population of CCL5-producing tissue-resident NK cells Muscle activation strategies of the vastus lateralis according to sex Synthetic periphyton as a model system to understand species dynamics in complex microbial freshwater communities