Spatial alanine metabolism determines local growth dynamics of Escherichia coli colonies
Antiviral activity of molnupiravir precursor NHC against SARS-CoV-2 Variants of Concern (VOCs) and its therapeutic window in a human lung cell model
Analysis of science journalism reveals gender and regional disparities in coverage Staphylococcus aureus-serine protease-like protein B (SplB) activates PAR2 and induces endothelial barrier dysfunction Cryo-EM Structures of the N501Y SARS-CoV-2 Spike Protein in Complex with ACE2 and Two Potent Neutralizing Antibodies SARS-CoV-2 infection induces soluble platelet activation markers and PAI-1 in the early moderate stage of COVID-19 Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition Pseudomonas aeruginosa C-terminal processing protease CtpA assembles into a hexameric structure that requires activation by a spiral-shaped lipoprotein binding partner Variation in female songbird state determines signal strength needed to evoke copulation State-dependent network interactions differentially gate sensory input at the motor and command neuron level in Caenorhabditis elegans Sablefish (Anoplopoma fimbria Pallas, 1814) plasma biochemistry and hematology reference intervals including blood cell morphology High performance single-cell gene regulatory network inference atscale: The Inferelator 3.0 The H4K20 demethylase DPY-21 regulates thedynamics of condensin DC binding Increased early sodium current causes familial atrial fibrillation and dampens effect of flecainide Medium-throughput zebrafish optogenetic platform identifies deficits in subsequent neural activity following brief early exposure to cannabidiol and Δ-9-tetrahydrocannabinol Synthetic periphyton as a model system to understand species dynamics in complex microbial freshwater communities In vitro pectate lyase activity and carbon uptake assays and whole genome sequencing of Bacillus amyloliquefaciens subsp. plantarum strains for a pectin defective pathway BatchDTA: Implicit batch alignment enhances deep learning-based drug-target affinity estimation Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas Multivariate genome-wide association study on tissue-sensitive diffusion metrics identifies key molecular pathways for axonal growth, synaptogenesis, and astrocyte-mediated neuroinflammation Tree invasions threaten the conservation potential and sustainability of U.S.rangelands Drug screening at single-organoid resolution via bioprinting and interferometry Sperm Histone H3 Lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction Cold stress upregulates the expression of heat shock and Frost genes, but the evolution of cold stress resistance is apparently not mediated through either heat shock or Frost genes in the cold stress selected populations of Drosophila melanogaster Genome editing excisase origins illuminated by somatic genome of Blepharisma