Tackling polypharmacology of kinase inhibitors and selecting chemical kinase probes by transcription factor activity profiling.
Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death
Entorhinal cortex epigenome-wide association study highlights four novel loci showing differential methylation in Alzheimer's disease Spatio-temporal patterns of multi-trophic biodiversity and food-web characteristics uncovered across a river catchment using environmental DNA Learning and motor inhibitory control in crows and domestic chickens Hematopoietic differentiation is characterized by a transient peak of entropy at a single cell level. Itaconate and its derivatives repress C2C12 myogenesis Sarcoplasmic reticulum calcium handling in young DBA/2J vs C57BL/10 mdx models of Duchenne muscular dystrophy Plasma proteome analyses in individuals of European and African ancestry identify cis-pQTLs and models for proteome-wide association studies Eye movements elevate crowding in idiopathic infantile nystagmus syndrome TNFa-induced LDL cholesterol accumulation involve elevated LDLR cell surface levels and SR-B1 downregulation in human arterial endothelial cellsan arterial endothelial cells Simpati: patient classifier identifies signature pathways based on similarity networks for the disease prediction Comparison of hybrid learning and remote education in the implementation of the 'Adopt a Microorganism' methodology Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition Population differences in the length and early-life dynamics of telomeres among European pied flycatchers Sperm Histone H3 Lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction Major orchestration of shikimate, early phenylpropanoid and stilbenoid pathways by Subgroup 2 R2R3-MYBs in grapevine Cellular Fitness Phenotypes of Cancer Target Genes from Oncobiology to Cancer Therapeutics Population bottleneck has only marginal effect on fitness evolution and its repeatability in dioecious C. elegans Microvesicles Transfer Mitochondria and Increase Mitochondrial Function in Brain Endothelial Cells 3D Reconstructions of Mouse Skeletal Muscle Reveal a Decrease in the MICOS Complex and Altered Mitochondrial Networks Correlation between speed and turning naturally arises for sparsely sampled cell movements A Hierarchy of Biomolecular Proportional-Integral-Derivative Feedback Controllers for Robust Perfect Adaptation and Dynamic Performance Recognition of discrete export signals in flagellar subunits during bacterial Type III secretion Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold. Effect of a low concentration in chloride, sodium and potassium on oocyte maturation, oocyte hydration, ovulation and egg quality in rainbow trout.