Mutualism-enhancing mutations dominate early adaptation in a microbial community
The Evolution of Protein Folds by Creative Destruction
LADON, a natural antisense transcript of NODAL, promotes an invasive behaviour in melanoma cells. The effect of resource depletion on the thermal response of mosquito population fitness Small proline-rich proteins (SPRRs) are epidermally produced antimicrobial proteins that defend the cutaneous barrier by direct bacterial membrane disruption Thirteen independent genetic loci associated with preserved processing speed in a study of cognitive resilience in 330,097 individuals in the UK Biobank Citation needed? Wikipedia and the COVID-19 pandemic Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition Inhibitory proteins block substrate access by occupying the active site cleft of Bacillus subtilis intramembrane metalloprotease SpoIVFB Gradients in cellular metabolism regulate development of tonotopy along the cochlea. Outsourced hearing in an orb-weaving spider that uses its web as an auditory sensor Artificial seawater based long-term culture of colonial ascidians Hematopoietic differentiation is characterized by a transient peak of entropy at a single cell level. Oncomodulin derived from regeneration-associated macrophages in dorsal root ganglia after preconditioning injury promotes sensory axon regeneration in the spinal cord Dysfunction of an energy sensor NFE2L1 triggers uncontrollable AMPK signal and glucose metabolism reprogramming Cryo-EM structure of the Rhodobaca bogoriensis RC-LH1-PufX dimeric complex at 2.9 A Differential regulation of degradation and immune pathways underlies adaptation of the ectosymbiotic nematode Laxus oneistus to oxic-anoxic interfaces Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death Multiplex knockout of trichome-regulating MYB duplicates in hybrid poplar using a single gRNA A mitochondria-specific mutational signature of aging: increased rate of A>G substitutions on a heavy chain. NOMA: a high-throughput microchip for robust, sequential measurements of secretions from the same single-cells Transplantation of high fat fed mouse microbiota into zebrafish larvae identifies MyD88-dependent acceleration of hyperlipidaemia by Gram positive cell wall components SERCA function is impaired in skeletal and cardiac muscles from young DBA/2J mdx mice Effects of Ancestry and Hypopigmentation Alleles on Skin Color in a Caribbean Native American Population Liberation from fibrogenesis or tumorigenesis via cellular senescence by a novel small molecule A humanized nanobody phage display library yields potent binders of SARS CoV-2 spike