Define protein variant functions with high-complexity mutagenesis libraries and enhanced mutation detection software ASMv1.0
Unifying Transcriptome Regulation and Cellular Operational Efficiency: Application of the Locality and Caching Principles via a Cell-to-Computer Analogy
An environmentally responsive transcriptional state modulates cell identities during root development HP1 oligomerization compensates for low-affinity H3K9me recognition and provides a tunable mechanism for heterochromatin-specific localization Genome streamlining, proteorhodopsin, and organic nitrogen metabolism in freshwater nitrifiers SARS-CoV-2 RdRp uses NDPs as a substrate and is able to incorporate NHC into RNA from diphosphate form molnupiravir Epigenetic scores for the circulating proteome as tools for disease prediction Mitochondria preserve an autarkic one-carbon cycle to confer growth-independent cancer cell migration and metastasis Fatal COVID-19 ARDS associated with incomplete AEC1 differentiation from the transitional state without senescence or fibrosis 'rbioacc': an R-package to analyse toxicokinetic data Trade-offs in biosensor optimization for dynamic pathway engineering Using top-down modulation to optimally balance shared versus separated task representations Ultrahigh-Throughput Ambient MS: Direct Analysis at 22 Samples per Second by Infrared Matrix-Assisted Laser Desorption Electrospray Ionization Mass Spectrometry An hidden Markov model to estimate homozygous-by-descent probabilities associated with nested layers of ancestors First detection of herpesvirus and prevalence of mycoplasma infection in free-ranging Hermann s tortoises (Testudo hermanni), and in potential pet vectors Sperm Histone H3 Lysine 4 tri-methylation serves as a metabolic sensor of paternal obesity and is associated with the inheritance of metabolic dysfunction Design of a radial multi-offset detection pattern for in vivo phase contrast imaging of the retinal ganglion cells in humans Embracing curiosity eliminates the exploration-exploitation dilemma A liquid +TIP-network regulates microtubule dynamics through tubulin condensation Preprints in motion: tracking changes between preprint posting and journal publication during a pandemic Effect of a low concentration in chloride, sodium and potassium on oocyte maturation, oocyte hydration, ovulation and egg quality in rainbow trout. Pseudomonas aeruginosa C-terminal processing protease CtpA assembles into a hexameric structure that requires activation by a spiral-shaped lipoprotein binding partner Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition Flexible seed size enables ultra-fast and accurate read alignment A bacterial extracellular vesicle-based intranasal vaccine against SARS-CoV-2 protects against disease and elicits neutralizing antibodies to wild-type virus and Delta variant Modelling homing suppression gene drive in haplodiploid organisms