Inhibition of BCMA signaling alters protein translation and Multiple Myeloma growth
Combined MEK and STAT3 inhibition reprograms stromal inflammation to overcome immunotherapy resistance in pancreatic cancer
Sensing their plasma membrane curvature allows migrating cells to circumvent obstacles The pH Dependence of Niclosamide Solubility, Dissolution, and Morphology Motivates Potentially Universal Mucin-Penetrating Nasal and Throat Sprays for COVID19, its Contagious Variants, and Other Respiratory Viral Infections Neutralization potential of Covishield vaccinated individuals sera against B.1.617.1 wnt16 exerts pleiotropic effects on bone and lean mass in zebrafish Dynamic tracing using ultra-bright labelling and multi-photon microscopy identifies endothelial uptake of poloxamer-188 coated poly(lactic-co-glycolic acid)nano-carriers in vivo A novel two-generation approach to the population dynamics of gregarious parasitoids Super-enhancer signature reveals key mechanisms associated with resistance to non-alcoholicsteatohepatitis in humans with obesity Deep inference of seabird dives from GPS-only records: performance and generalization properties The Functional Nanopore Screen: A Versatile High-throughput Assay to Study and Engineer Protein Nanopores in Escherichia coli Correlative all-optical quantification of mass density and mechanics of sub-cellular compartments with fluorescence specificity Allopurinol Blocks The Formation And Progression Of Aortic Aneurysm In A Mouse Model Of Marfan Syndrome Usutu virus escapes langerin-induced restriction to productively infect human Langerhans cells, unlike West Nile virus. Oscillations support short latency co-firing of neurons during human episodic memory formation. RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses. Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance Identifying complex motifs in massive omics data with a variable-convolutional layer in deep neural network A Substrate-triggered μ-Peroxodiiron(III) Intermediate in the 4-Chloro-L-Lysine-Fragmenting Heme-Oxygenase-like Diiron Oxidase (HDO) BesC: Substrate Dissociation from, and C4 Targeting by, the Intermediate A chemical screen based on an interruption of zebrafish gastrulation identifies the HTR2C inhibitor Pizotifen as a suppressor of EMT-mediated metastasis On-pathway multivalency of a broadly neutralizing evolution drug candidate Hierarchical clustering optimizes the tradeoff between compositionality and expressivity of task structures for flexible reinforcement learning The Evolution of Protein Folds by Creative Destruction Text has been revised, image definition has been revised. Preprints in motion: tracking changes between preprint posting and journal publication during a pandemic