Single-molecule imaging of cytoplasmic dynein in cellulo reveals the mechanism of motor activation and cargo capture
Glucose regulates expression of pro-inflammatory genes IL-1β and IL-12 through a mechanism involving hexosamine biosynthesis pathway dependent regulation of α-E catenin in the RAW 264.7 macrophage cell line
Identifying and correcting multiple sources of misspecification in GWAS summary statistics for polygenic scores Parallel Characterization of cis-Regulatory Elements for Multiple Genes Using CRISPRpath Bacterial but not fungal rhizosphere communities differ among perennial grass ecotypes under abiotic environmental stress Glucose inhibits haemostasis and accelerates diet-induced hyperlipidaemia in zebrafish larvae Trade-offs in biosensor optimization for dynamic pathway engineering Hierarchical clustering optimizes the tradeoff between compositionality and expressivity of task structures for flexible reinforcement learning Ultra-deep through-skull mouse brain imaging via the combination of skull optical clearing and three-photon microscopy Poly ADP-ribosylation of SET8 leads to aberrant H4K20 methylation domains in mammalian cells Comparison of hybrid learning and remote education in the implementation of the 'Adopt a Microorganism' methodology An Immune Cell Atlas Reveals Dynamic COVID-19 Specific Neutrophil Programming Amenable to Dexamethasone Therapy Mapping densely packed GPIIb/IIIa receptors in murine blood platelets with expansion microscopy Loss of SUMO-specific protease 2 causes isolated glucocorticoid deficiency by blocking adrenal cortex zonal transdifferentiation Neurological mechanism of sensory deficits after developmental exposure to non-dioxin-like polychlorinated biphenyls (PCBs) in zebrafish larvae Text has been revised, image definition has been revised. Polycomb suppresses a female gene regulatory network to ensure testicular differentiation Naturally occurring combinations of receptors from single cell transcriptomics in endothelial cells Bioinformatic and mechanistic analysis of the palmerolide PKS-NRPS biosynthetic pathway from the microbiome of an Antarctic ascidian Spatio-temporal, optogenetic control of gene expression in organoids Shorter effective lifespan in laboratory populations of D. melanogaster might reduce sexual selection. Chromatin accessibility landscape and active transcription factors in primary human invasive lobular and ductal breast carcinomas Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition Egress of human cytomegalovirus through multivesicular bodies Effects of substrate on shrimp growth, water quality and bacterial community in the biofloc system nursing Penaeus vannamei postlarvae Tree encroachment threatens the conservation potential and sustainability of U.S. rangelands