An alternatively spliced TREM2 isoform lacking the ligand binding domain is expressed in human brain
RNF213 loss of function reshapes vascular transcriptome and spliceosome leading to disrupted angiogenesis and aggravated vascular inflammatory responses.
An early signaling GARP transcription factor regulates the entry point for differentiation in Giardia Allopurinol Blocks The Formation And Progression Of Aortic Aneurysm In A Mouse Model Of Marfan Syndrome Microbial loop of a Proterozoic ocean analogue Design, Mutate, Screen: High-throughput creation of genetic clocks with different period-amplitude characteristics Structure-Functional-Selectivity Relationship Studies on A-86929 Analogs and Small biaryl Fragments toward Discovery of biased D1 agonists Design of Specific Primer Sets for the Detection of SARS-CoV-2 Variants of Concern B.1.1.7, B.1.351, P.1, B.1.617.2 using Artificial Intelligence Mechanistic basis for understanding the dual activities of the bifunctional Azotobacter vinelandii mannuronan C-5 epimerase and alginate lyase AlgE7 Preprints in motion: tracking changes between preprint posting and journal publication during a pandemic Plasma membrane damage limits replicative lifespan in yeast and induces premature senescence in human fibroblasts Construction of a new chromosome-scale, long-read reference genome assembly for the Syrian hamster, Mesocricetus auratus A novel method for producing functionalized vesicles that efficiently deliver oligonucleotides in vitro in cancer cells and in vivo in mice Flexible reprogramming of Pristionchus pacificus motivation for attacking Caenorhabditis elegans in predator-prey competition Atomic Force Microscopy Reveals Distinct Protofilament-scale Structural Dynamics in Depolymerizing Microtubule Arrays First detection of herpesvirus and frequency of mycoplasma infection in free-ranging Hermann s tortoises (Testudo hermanni), and in potential pet vectors The ribose methylation enzyme FTSJ1 has a conserved role in neuron morphology and learning performance Isoprenoid biosynthesis regulation in poplars by methylerythritol phosphate and mevalonic acid pathways Evidence of an additional wild contributor, Malus orientalis Uglitzk., to the genome of cultivated apple varieties in the Caucasus and Iran Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition Optogenetic activation of the neural circuit between dorsal raphe nucleus and the pre-Botzinger complex contributes to inhibition of the seizure-induced respiratory arrest in the DBA/1 mouse SUDEP model Proteomics reveals unique identities of human TGF-β-induced and thymus-derived CD4+ regulatory T cells Depletion of CD206+ Tumour Macrophages via a Peptide-Targeted Star-Shaped Polyglutamate Inhibits Tumourigenesis and Metastatic Dissemination in Breast Cancer Models A map of binary SARS-CoV-2 protein interactions implicates host immune regulation and ubiquitination Force profile of the two-handed hardstyle kettlebell swing in novice older adults: an exploratory profile Hierarchical Bayesian Integrated Model for Estimating Migratory Bird Harvest in Canada