SENIES: DNA Shape Enhanced Two-layer Deep Learning Predictor for the Identification of Enhancers and Their Strength
A memetic algorithm enables efficient local and global all-atom protein-protein docking with backbone and sidechain flexibility
Point Mutations in SARS-CoV-2 Variants Induce Long-Range Dynamical Perturbations in Neutralizing Antibodies Human centromere formation activates transcription and opens chromatin fibre structure Perceptual gating of a brainstem reflex facilitates speech understanding in human listeners A Wnt/β-catenin signaling driven adipocyte population required for beiging and glucose homeostasis Inhibition of BCMA signaling alters protein translation and Multiple Myeloma growth Fine-scale coexistence between Mediterranean mesocarnivores is mediated by spatial, temporal and trophic resource partitioning Production and characterization of virus-free, CRISPR-CAR T cells capable of inducing solid tumor regression Localization of signaling receptors maximizes cellular informationacquisition in spatially-structured natural environments High-Potency Polypeptide-based Inhibition of Enveloped-virus Glycoproteins Hypoxia reduces cell attachment of SARS-CoV-2 spike protein by modulating the expression of ACE2, neuropilin-1, syndecan-1 and cellular heparan sulfate The female pheromone (Z)-4-undecenal mediates flight attraction and courtship in Drosophila melanogaster Co-infection of Candidatus Piscichlamydia trichopodus (order Chlamydiales) and Henneguya sp (Myxosporea, Myxobolidae) in snakeskin gourami Trichopodus pectoralis (Regan 1910) Frequency modulated timer regulates mammalian hibernation PIN-FORMED1 polarity in the shoot is insensitive to the polarity of neighbouring cells Trade-offs in biosensor optimization for dynamic pathway engineering Genetic analysis of mitochondrial DNA copy number and associated traits identifies loci implicated in nucleotide metabolism, platelet activation, and megakaryocyte proliferation, and reveals a causal association of mitochondrial function with mortality Itaconate and derivatives reduce interferon responses and inflammation in influenza A virus infection Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition If Research is Not the Evidence, What is it? The Lack of Research Citations in Health Vlogs Inhibitors of ERp44, PDIA1, and AGR2 induce disulfide-mediated oligomerization of Death Receptors 4 and 5 and cancer cell death Thirteen independent genetic loci associated with preserved processing speed in a study of cognitive resilience in 330,097 individuals in the UK Biobank Late-life fitness gains explain the absence of a selection shadow in ants A signalling axis involving CNOT3, Aurora B and ERK promotes differentiation and survival of mesendodermal progenitor cells Egress of human cytomegalovirus through multivesicular bodies