Global analysis of multi-mutants to improveprotein function
Nucleus size and its effect on the chromatin structure in living cells.
Can double PPO mutations exist in the same allele and are such mutants functional? An mRNA SARS-CoV-2 vaccine employing Charge-Altering Releasable Transporters with a TLR-9 agonist induces neutralizing antibodies and T cell memory Reconstitution of minimal motility system based on Spiroplasma swimming by expressing two bacterial actins in synthetic minimal bacterium In vitro evolution of uracil glycosylase towards DnaKJ and GroEL binding evolves different misfolded states Construction of a new chromosome-scale, long-read reference genome assembly for the Syrian hamster, Mesocricetus auratus Fusobacterium nucleatum induces pancreatic cancer cell proliferation and migration by regulating host autocrine and paracrine signaling First detection of herpesvirus and frequency of mycoplasma infection in free-ranging Hermann s tortoises (Testudo hermanni), and in potential pet vectors Precartilage condensation during limb skeletogenesis occurs by tissue phase separation controlled by a bistable cell-state switch with suppressed oscillatory dynamics Ineffectual AEC1 differentiation from KRT8hi transitional state without fibrosis is associated with fatal COVID-19 ARDS Greater spear nosed bats in Panama do not use social proximity to improve foraging efficiency What is valued in conservation? A framework to compare ethical perspectives Differential regulation of degradation and immune pathways underlies adaptation of the ectosymbiotic nematode Laxus oneistus to oxic-anoxic interfaces Advanced Functional Biotextiles for a Circular Materials Economy An estimation of the absolute number of axons indicates that human cortical areas are sparsely connected Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition Simple and practical sialoglycan encoding system reveals vast diversity in nature and identifies a universal sialoglycan-recognizing probe derived from AB5 toxin B subunits Substrate specialization in microbes is driven by biochemical constraints of dynamic flux sensing Amino acids targeted based metabolomics study in non-segmental Vitiligo: a pilot study An alternatively spliced TREM2 isoform lacking the ligand binding domain is expressed in human brain A novel nongenetic murine model of hyperglycemia and hyperlipidemia-associated aggravated atherosclerosis Arabidopsis AtPME2 has a pH-dependent processivity and control cell wall mechanical properties Proteogenomics: an analysis of how and when itenhances proteomics Basal Gp78 mitophagy promotes mitochondrial health and limits mitochondrial ROS production Comparison of hybrid learning and remote education in the implementation of the 'Adopt a Microorganism' methodology