Beta-cell specific Insr deletion promotes insulin hypersecretion and improves glucose tolerance prior to global insulin resistance
Small extracellular vesicles from young mice prevent frailty, improve healthspan and decrease epigenetic age in old mice.
Sablefish (Anoplopoma fimbria Pallas, 1814) plasma biochemistry and hematology reference intervals including blood cell morphology Rho Kinase regulates neutrophil NET formation that is involved in UVB-induced skin inflammation A Hierarchy of Biomolecular Proportional-Integral-Derivative Feedback Controllers for Robust Perfect Adaptation and Dynamic Performance Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment Egress of human cytomegalovirus through multivesicular bodies ATP binding facilitates target search of SWR1 chromatin remodeler by promoting one-dimensional diffusion on DNA Variation in female songbird state determines signal strength needed to evoke copulation Designing single-cell experiments to harvest fluctuation information while rejecting measurement noise Activity in perirhinal and entorhinal cortex predicts perceived visual similarities among category exemplars with highest precision Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition Somatic mutations of activated signaling genes, transcription factors, or tumor suppressors are a precondition for leukemic transformation from myelodysplastic syndromes: a sequencing analysis of 64 paired samples If Research is Not the Evidence, What is it? The Lack of Research Citations in Health Vlogs Relationship between shear wave velocity and muscle activation is inconsistent across different muscle types Visualization of loop extrusion by DNA nanoscale tracing in single human cells Brain endothelial STING1 activation by Plasmodium-sequestered heme promotes cerebral malaria via type I IFN response. Tree encroachment threatens the conservation potential and sustainability of U.S. rangelands A rationalized definition of tumor suppressor microRNAsexcludes miR-34a Non-targeted multimodal metabolomics and lipidomics data from ovine rumen fluid fractions Embryonic exposure to cannabidiol disrupts active neural circuits, an effect increased by Δ-9-tetrahydrocannabinol and involving CB1R and CB2R in zebrafish Phytoene synthase 2 in tomato fruits remains functional and contributes to abscisic acid formation Optimal strategies for learning multi-ancestry polygenic scores vary across traits DNA-controlled Spatio-temporal Patterning of a Cytoskeletal Active Gel Constraints on the evolution of toxin-resistant Na,K-ATPases have limited dependence on sequence divergence Metacells untangle large and complex single-cell transcriptome networks