Cis-Regulatory Element Hijacking by Structural Variants Overshadows Higher-Order Topological Changes in Primary Prostate Cancer
Somatic mutations of activated signaling genes, transcription factors, or tumor suppressors are a precondition for leukemic transformation from myelodysplastic syndromes: a sequencing analysis of 64 paired samples
TXN, a Xanthohumol Derivative, Attenuates High-Fat Diet Induced Hepatic Steatosis by Antagonizing PPARγ A chemical screen based on an interruption of zebrafish gastrulation identifies the HTR2C inhibitor Pizotifen as a suppressor of EMT-mediated metastasis Development of a Novel PROTAC using the Nucleic Acid Aptamer as a Targeting Ligand for Tumor Selective Degradation of Nucleolin Potent but transient immunosuppression of T-cells is a general feature of CD71+ erythroid cells Ovule siRNAs methylate protein-coding genes in trans Spontaneous Transmembrane Pore Formation by Short-chain Synthetic Peptide A Novel Organoid Model of In Vitro Spermatogenesis Using Human Induced Pluripotent Stem Cells Common physiological processes control mercury reduction during photosynthesis and fermentation Genome-scale metabolic modeling reveals SARS-CoV-2-induced metabolic changes and antiviral targets Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition Simulation of foraging behavior using a decision-making agent with Bayesian and inverse Bayesian inference: Temporal correlations and power laws in displacement patterns Polycystins are upregulated in fibrotic kidneys and promote renal fibrosis Imbalanced segregation of recombinant haplotypes in hybrid populations reveals inter- and intrachromosomal Dobzhansky-Muller incompatibilities Selection towards lighter seeds in Danish grasslands over an eight-year period Define and visualize pathological architectures of human tissues from spatially resolved transcriptomics using deep learning Feed efficiency of lactating Holstein cows was not as repeatable across diets as within diet over subsequent lactation stages Mean-field approximation of network of biophysical neurons driven by conductance-based ion exchange GCN5L1 promotes diastolic dysfunction by inhibiting cardiac pyruvate oxidation Synthetic periphyton as a model system to understand species dynamics in complex microbial freshwater communities Motor Protein MYO1C is Critical for Photoreceptor Opsin Trafficking and Visual Function Naming Human Diseases: Ethical Principles of Curating Exclusive Substitute for Inopportune Nosology Genome archaeology of two laboratory Salmonella enterica enterica sv Typhimurium Structure-Functional-Selectivity Relationship Studies on A-86929 Analogs and Small biaryl Fragments toward Discovery of biased D1 agonists Multivariate genome-wide association study on tissue-sensitive diffusion metrics identifies key molecular pathways for axonal growth, synaptogenesis, and astrocyte-mediated neuroinflammation