Assessment and Optimization of the Interpretability of Machine Learning Models Applied to Transcriptomic Data
Defining An Expanded RAS Conformational Landscape Based on Over 700 Experimentally Determined Structures of KRAS, NRAS, and HRAS
A novel Boolean network inference strategy to model early hematopoiesis aging Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition Dramatic differences in male and female mortality trends for selected European cohorts over ~20 years. Comparative genomics provides insight into the function of broad-host range sponge symbionts Maternal Western-Style Diet Impairs Bone Marrow Development and Drives a Hyperinflammatory Phenotype in Hematopoietic Stem and Progenitor Cells in Fetal Rhesus Macaques Design, Mutate, Screen: High-throughput creation of genetic clocks with different period-amplitude characteristics Age-associated changes to neuronal dynamics involve a disruption of excitatory/inhibitory balance in C. elegans Decoding the porcine developing spatial processing system and production of human entorhinal stellate cell-like cells by a direct programming approach. Long-read and chromosome-scale assembly of the hexaploid wheat genome achieves high resolution for research and breeding Human 14-3-3 proteins site-selectively bind the mutational hotspot region of SARS-CoV-2 nucleoprotein modulating its phosphoregulation RapidoPGS: A rapid polygenic score calculator for summary GWAS data without a test dataset Preprints in motion: tracking changes between preprint posting and journal publication during a pandemic Rattus Economicus: A neural model for rational regulation of water-seeking effort in rodents Interfacial tension driven open droplet microfluidics Neurological mechanism of sensory deficits after developmental exposure to non-dioxin-like polychlorinated biphenyls (PCBs) in zebrafish larvae Yolk sac-derived bipotent endothelial-macrophage progenitor cells are a self-renewing tissue-resident source of inflammation and neovascularization postnatally Somatic mutations of activated signaling genes, transcription factors, or tumor suppressors are a precondition for leukemic transformation from myelodysplastic syndromes: a sequencing analysis of 64 paired samples Re-convolving the compositional landscape of primary and recurrent glioblastoma reveals prognostic andtargetable tissue states Relationships between aboveground plant traits and carbon cycling in tundra plant communities Modifying root/shoot ratios improves root water influxes in wheat under drought stress Dilute phase oligomerization can oppose phase separation and modulate material properties of a ribonucleoprotein condensate Tracing back variations in archaeal cell division to protein domain architectures On the incongruence of genotype-phenotype and fitness landscapes A nontoxic tetrodotoxin analog, 5,6,11-trideoxytetrodotoxin, as an olfactory chemoattractant for the grass puffer