Frameshift and wild-type proteins are highly similar because the genetic code and genomes were optimized for frameshift tolerance
The maize gene maternal derepression of r1 (mdr1) encodes a DNA glycosylase that demethylates DNA and reduces siRNA expression in endosperm
Multiple types of genomic variation contribute to adaptive traits in the mustelid subfamily Guloninae The Rab GTPase activating protein TBC-2 regulates endosomal localization of DAF-16 FOXO and lifespan Computational modeling and quantitative cell physiology reveal central parameters for the brassinosteroid-regulated cell growth of the Arabidopsis root The Roles of APOBEC-mediated RNA Editing in SARS-CoV-2 Mutations, Replication, and Fitness Resolving when (and where) the Thylacine went extinct LPS-TLR4 pathway exaggerates alcohol-induced acute-on-chronic liver failure via provoking NETs formation Identification of differentially distributed gene expression and distinct sets of cancer-related genes identified by changes in mean and variability Regulatory perturbations of ribosome allocation optimize the growth proteome with a trade-off in adaptation capacity Spatio-temporal patterns of multi-trophic biodiversity and food-web characteristics uncovered across a river catchment using environmental DNA A platform of patient-derived microtumors identifies individual treatment responses and therapeutic vulnerabilities in ovarian cancer. Elucidating Microscopic Events Driven by GTP Hydrolysis Reaction in Ras-GAP System with Semi-reactive Molecular Dynamics Simulation: Alternative Role of Phosphate Binding Loop as Mechanical Energy Storage Regulation of the PKD2 channel function by TACAN Crowdsourced identification of multi-target kinase inhibitors for RET- and TAU- based disease: the Multi-Targeting Drug DREAM Challenge Cell trajectory modeling identifies a primitive trophoblast state defined by BCAM enrichment A comparison of high resolution image reconstruction methods from confocal array detector with a new deconvolution algorithm Evidence for Deleterious Antigenic Imprinting in SARS-CoV-2 Immune Response Dynamic distortion of orientationrepresentation after learning in the mouseprimary visual cortex Diverse stem-chondrichthyan oral structures and evidence for an independently acquired acanthodid dentition "Adopt a Microorganism" methodology enhances the discourse richness of high school students in both hybrid learning and remote education Foraging with friends, moving with anyone: effects of the social environment on movement-integrated habitat selection Non canonical scaffold-type ligase complex mediates protein UFMylation New Segmentation and Feature Extraction Algorithm for Classification of White Blood Cells in Peripheral Smear Images Crystal structures of alphavirus nonstructural protein 4 (nsP4) reveal an intrinsically dynamic RNA-dependent RNA polymerase fold. The obstacles and potential clues of prime editing applications in tomato, a dicot plant