Which Route 22 runs through a major city?
Edenburg, Pennsylvania:  As of the 2010 census, the population was 681 residents. U.S. Route 22 in Pennsylvania:  In Pennsylvania, the route runs for 337.60 mi between the West Virginia state line at Washington County, where it is a limited-access expressway-grade route through the western suburbs of Pittsburgh, to the New Jersey state line at Easton.
i don't know