In what year did Indiana Colts first draft and first ever selection pick win the Heisman Trophy?
Indianapolis Colts draft history:  The first draft that the current incarnation of the Colts franchise participated in was 1953, in which they made halfback Billy Vessels of Oklahoma their first ever selection. Billy Vessels:  He played college football at the University of Oklahoma and won the Heisman Trophy in 1952.
1952