Who directed the 2010 film that caused Katherine Heigl to be absent from "Invest in Love"?
Invest in Love:  Katherine Heigl (Dr. Izzie Stevens) was absent from the episode, as she was filming the 2010 blockbuster "Life as We Know It". Life as We Know It (film): Life As We Know It is a 2010 American romantic comedy-drama film directed by Greg Berlanti, starring Katherine Heigl and Josh Duhamel.
Greg Berlanti