The actress that played Jackie Harris on "Roseanne" also appeared with John Candy and Amy Madigan in a 1989 comedy film directed by who?
Uncle Buck: Uncle Buck is a 1989 American comedy film directed by John Hughes and starring John Candy and Amy Madigan, with Jean Louisa Kelly, Gaby Hoffmann, Macaulay Culkin, Jay Underwood, and Laurie Metcalf in supporting roles. Laurie Metcalf:  She is known for her television roles as Jackie Harris on the ABC sitcom "Roseanne" (1988–97); Carolyn Bigsby on "Desperate Housewives" (2006); the recurring role of Mary Cooper on "The Big Bang Theory" (2007–present); Dr. Jenna James on "Getting On" (2013–15), and Marjorie McCarthy in "The McCarthys" (2014–15).
John Hughes