"Separation Anxiety" is the fifth season premiere of which American spy thriller drama television series,  and the 49th episode overall, that premiered on Showtime on October 4, 2015? 
Homeland (TV series): Homeland is an American spy thriller television series developed by Howard Gordon and Alex Gansa based on the Israeli series "Prisoners of War" (Original title חטופים "Hatufim ", literally "Abductees"), which was created by Gideon Raff.
i don't know