Botiller v. Dominguz was a decision by the United States Supreme Court that dealt with a region of the southwestern United States that was the third largest acquisition of territory in US history, with what being the largest? 
Botiller v. Dominguez: Botiller v. Dominguez, 130 U.S. 238 (1889), was a decision by the United States Supreme Court dealing with the validity of Spanish or Mexican land grants in the Mexican Cession, the region of the present day southwestern United States that was ceded to the U.S. by Mexico in 1848 under the Treaty of Guadalupe Hidalgo. Mexican Cession:  The Mexican Cession (529,000 sq. miles) was the third largest acquisition of territory in US history. Mexican Cession:  The largest was the Louisiana Purchase, with some 827,000 sq. miles, followed by the acquisition of Alaska (about 586,000 sq. miles).
i don't know