Which Route 22 runs through a major city?
U.S. Route 22 in Pennsylvania: U.S. Route 22 (US 22) is an east–west route stretching from Cincinnati, Ohio in the west to Newark, New Jersey in the east. U.S. Route 22 in Pennsylvania:  In Pennsylvania, the route runs for 337.60 mi between the West Virginia state line at Washington County, where it is a limited-access expressway-grade route through the western suburbs of Pittsburgh, to the New Jersey state line at Easton.
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