Which river that streams westward from Pittsburgh, Pennsylvania, to Cairo, Illinois is the northern boundary of Downtown Louisville?
Downtown Louisville:  Its boundaries are the Ohio River to the north, Hancock Street to the east, York and Jacob Streets to the south, and 9th Street to the west. Ohio River: The Ohio River, which streams westward from Pittsburgh, Pennsylvania, to Cairo, Illinois, is the largest tributary, by volume, of the Mississippi River in the United States.
Ohio River