Transocean Air Lines Flight 512 crashed into the Pacific Ocean east of which island that is one of the most isolated islands in the world?  
Transocean Air Lines Flight 512:  On 12 July 1953, at approximately 08:41 GMT, the aircraft serving the flight, a Douglas DC-6A, registration N90806, crashed into the Pacific Ocean roughly 630 km (340 nmi) east of Wake Island while "en route" to Honolulu. Wake Island:  Wake Island is one of the most isolated islands in the world and the nearest inhabited island is Utirik Atoll in the Marshall Islands, 592 mi to the southeast.
Wake Island