Which large pre-Columbian archaeological site is the major Zapotec regional center?
El Palmillo:  Located on a hilltop in the eastern Tlacolula arm of the valley, El Palmillo is just to the south of the pre-Columbian site of Mitla and to the east of the major Zapotec regional center, Monte Albán. Monte Albán: Monte Albán, likely originally called Danipaguache (Zapotec for sacred mountain of life), is a large pre-Columbian archaeological site in the Santa Cruz Xoxocotlán Municipality in the southern Mexican state of Oaxaca (17.043° N, 96.767°W).
Monte Albán