What airline did one of the "Big Four" domestic airlines in the United States collide with over Carmel, New York?
1965 Carmel mid-air collision: The 1965 Carmel mid-air collision occurred on December 4, 1965, when Eastern Air Lines Flight 853 (N6218C), a Lockheed Super Constellation en route from Boston Logan International Airport to Newark International Airport, collided in mid-air with Trans World Airlines Flight 42 (N748TW), a Boeing 707-131B en route from San Francisco International Airport to John F. Kennedy International Airport, over Carmel, New York, United States. Trans World Airlines:  It was formed as Transcontinental & Western Air to operate a route from New York City to Los Angeles via St. Louis, Kansas City, and other stops, with Ford Trimotors. With American, United, and Eastern, it was one of the "Big Four" domestic airlines in the United States formed by the Spoils Conference of 1930.
Eastern Air Lines