Here is a news article: The victim of the vicious flesh-eating attacker on the MacArthur Causeway on Saturday has been identified as 65-year-old Ronald Poppo, The Miami Herald has learned.

 Poppo remains in critical condition at Ryder Trauma Center with horrific facial injuries.

 His attacker, killed by Miami police at the crime scene, has also been identified as Rudy Eugene, who as a teenager in the late 1990s played high school football at North Miami Beach High.

 How the men's paths crossed in such a violent act remains unclear.

 More recently, court records show that Eugene was married in 2005 and divorced in 2007. According to the filing, he had no income and his assets included $2 cash and $50 for a cellphone.

 His former wife, Jenny Ductant, agreed to take on the couple's debt, which included the power and phone bills.

 "I don't want to talk about it," she said Tuesday when reached on her cellphone.

 The man Eugene attacked remained in extremely critical condition Monday at Jackson Memorial Hospital. Much of his face was gone, the skin ripped away, the nose bitten and the eyes gouged.

 What remained was his goatee and little else.

 Photos of the scene with Eugene and his victim quickly went viral on the Internet Monday.

 Were hoping that he pulls through, for his well-being, but also so he can tell us what happened, said Sgt. Javier Ortiz, vice president of the Miami police union. Only he knows.

 Details about Eugene's life in South Florida were emerging on Tuesday.

 As a teenager, he lived in North Miami-Dade, attending North Miami Beach High and North Miami High, where he was on the football team.

 The Miami Herald has obtained photographs of Eugene from North Miami Beach High yearbooks. One photograph was taken in 1997; the other was taken in 1998 when he was a junior. A group shot of the high school football team incudes Eugene.

 Eugene transferred to North Miami Senior for his final year of high school, North Miami Beach Principal Raymond Fontana said on Tuesday.

 He was killed by police on Saturday as a macabre scene unfolded about 2 p.m. on the MacArthur Causeways off-ramp to Biscayne Boulevard just south of the Miami Herald building. A Road Ranger spotted Eugene and his victim in what appeared to be a violent struggle and shouted on his loudspeaker for the naked attacker to back away.

 One witness said he was riding his bicycle on the MacArthur when he saw a man tearing off pieces of the victims flesh with his mouth. After an officer approached, Larry Vega told WSVN-FOX7, The guy just stood, his head up like that, with pieces of flesh in his mouth. And he growled.

 Eugene left behind few clues as to what could have prompted the attack.

 I wouldnt say he had mental problem but he always felt like people was against him . .. No one was for him, everyone was against him, his ex-wife told WPLG.

 He had just one arrest to suggest serious violence. Miami Beach police arrested him on a battery charge when he was 16, according to the Florida Department of Law Enforcement. The charge was later dropped.

 He was arrested seven other times over five years. Court records show that one was for misdemeanor battery, one was for vending near a school, one was for trespassing and four involved marijuana.

 The last case came in September 2009. In January, the charge was dropped.

 During Saturdays attack, an officer approached and told Eugene to get off his victim, but Eugene ignored the order and kept chewing, even after the officer shot him once.

 The officer fired again, hitting him several more times, eventually killing him. The name of that officer was not released.

 Security video from the adjacent Miami Herald building captured snippets of the violence as the two men  one dead, the other gravely injured and wearing only a shirt  lay on the sidewalk as officers arrived. .

 Days later, the chatter, theories and questions continued. The ghoulish event even spawned a Twitter account, dubbed The Miami Zombie.

 An emergency room doctor at Jackson Memorial Hospital said Eugenes attack could have been induced by bath salts, a drug nicknamed after the bathroom product it resembles.

 Police theorized earlier that it was cocaine psychosis, a drug-induced craze that bakes the body internally and often leads those it affects to strip naked to try to cool off.

 Investigators asked any witnesses who have not stepped forward to call the Miami police homicide unit at 305-603-6350.

 Miami Herald writers Luisa Yanez and Daniela Guzman contributed to this report, which includes information from Miami Herald news partner WFOR CBS 4. ||||| MIAMI -

 Sources identified the man who was shot and killed by police while biting off parts of another man's face near Downtown Miami on Saturday.

 Police sources identified the man as Rudy Eugene.

 Police said Eugene, 31, was found attacking another man near the west end of the MacArthur Causeway and Biscayne Boulevard on Saturday afternoon.

 "When the officer approached him, told him to stop, pointed a gun at him, he turned around and growled like a wild animal and kept eating at the man's face," Fraternal Order of Police President Armando Aguilar said Sunday.

 A witness said Eugene was biting off pieces of the other man's face and tossing them aside. He described it as looking like a scene out of The Walking Dead.

 Police then shot and killed Eugene after attempting to stop the assault.

 It's unclear what sparked the fight.

 Aguilar said Eugene had likely overdosed, citing four past instances in Miami-Dade County when people overdosed on a type of LSD, removed their clothes, and became violent.

 "It causes them to go completely insane and become very violent," said Aguilar.

 The victim, a homeless man who frequents the same area where he was nearly killed, is listed in critical condition at Jackson Memorial Hospital.

 Aguilar said 75 to 80 percent of the victim's face was missing.

 Both men have had prior run-ins with law enforcement. Miami-Dade court records for both show both men have been arrested for mostly a handful of misdemeanors.

 Who is Rudy Eugene?

 Eugene was previously married. He met his now ex-wife in high school at North Miami Beach Senior High.

 Their marriage was short-lived, lasting a year and a half.

 "I wouldn't say he had mental problem but he always felt like people was against him type of attitude. No one was for him, everyone was against him," said Eugene's ex-wife.

 The two filed for divorce in 2007 during a violent point in their relationship.

 The woman told Local 10's Terrell Forney that Eugene became increasingly violent toward her.

 "That's why I left," said Eugene's ex-wife.

 The two had not spoken in three or four years.

 A woman who answered the door at Eugene's former North Miami Beach home told Local 10 that the prior family had lost the 1-story house to foreclosure in 2011.

 However, Eugene would often pop up to the home unannounced, often looking for mail, which made the new family uncomfortable.

 "He kind of looked weird a little bit but other than that I said as long as I've got bats and got the alarm system put up, I was okay," said the woman.

 The homeless, who camp near where it all happened, say they knew Eugene. They saw him frequently in that area walking around confused.

 "I was actually talking to him the other day," one homeless man said. "It's pretty weird." |||||
A summary of this is?

– The Miami man shot dead as he chewed off another man's face has been identified as 31-year-old Rudy Eugene. He had a criminal record but nothing on the scale of Sunday's crazed attack, the Miami Herald finds. He was arrested on a battery charge when he was 16, and was busted seven other times between 2004 and 2009 for charges including vending near a school, trespassing, and marijuana-related offenses. He was married for more than a year to a woman who says he became increasingly violent with her. "I wouldn't say he had mental problem, but he always felt like people was against him. No one was for him, everyone was against him," his ex-wife, who filed for divorce in 2007, tells WPLG. At Eugene's former home, a woman says the previous occupants lost the home to foreclosure last year, but Eugene would often turn up unannounced looking for mail. Eugene's victim, who lost most of his face in the attack, is fighting for his life in a local hospital, and police still aren't sure what prompted the horrific attack. They believe it could have been cocaine psychosis or an overdose of "bath salts," a synthetic drug one police spokesman likens to a potent new kind of LSD.


Write an article based on this summary:

– One of the world's top mountain climbers fell to this death today, reports the BBC. Switzerland's Erhard Loretan—one of a relative handful of climbers to have scaled all 14 world peaks above 8,000 meters (26,247 feet)—fell after a climbing accident in the Swiss Alps. Loretan was known for another incident that marred his acclaim: He pleaded guilty to negligent manslaughter in 2001 after shaking his 7-month-old son to stop his crying. The death led to research highlighting the dangers of shaken baby syndrome, notes the Los Angeles Times.

Swiss mountaineer Erhard Loretan, one of the few climbers to have summited all 14 of the world's peaks above 8,000 meters (26,247 feet), died in a climbing accident on Thursday, his 52nd birthday.

 The Associated Press reported that Loretan was leading a Swiss client up the summit ridge of the Gruenhorn, in the Bernese Alps, when the pair fell for unknown reasons at a height of 3,800 meters (12,500 feet) up the 4,043 meter (13,264-foot) peak. Police from the Swiss canton of Valais said that Loretan died at the scene, while his 38-year-old client was flown to a hospital in serious condition.

 Loretan, originally from the canton of Fribourg, began climbing at age 11. He ascended his first 8,000-meter peak, Pakistan's Nanga Parbat, in 1982. It took him 13 years to climb the other 13, summiting the Himalayan peak of Kangchenjunga in 1995.

 Loretan was the third person, behind Italian climber Reinhold Messner and Polish mountaineer Jerry Kukuczka, to summit all the 8,000-meter peaks.

 Loretan was also renowned for his 1986 ascent of Mt. Everest in only 40 hours, climbing by night without the use of supplementary oxygen.

 Loretan's acclaim was marred by the tragic 2001 death of his 7-month-old son, who was killed when Loretan shook him to stop his crying. Loretan pleaded guilty to negligent manslaughter and was given a four-month suspended sentence. The case's notoriety led to new research showing that infants can die from being shaken.

 -- Kelly Burgess

 Twitter.com/latimesoutposts

 Photo: Erhard Loretan in 1998. Credit: Associated Press / Keystone / STR

  ||||| Image caption Loretan began climbing aged 11

 Renowned Swiss climber Erhard Loretan has died in a climbing accident in the Swiss Alps on his 52nd birthday.

 Swiss police say Loretan was leading a client up the summit ridge of the Gruenhorn, in the Bernese Alps, on Thursday afternoon when the pair fell.

 The climber died at the scene, while his Swiss client was flown to hospital in a serious condition.

 Loretan was one of the few people to have reached the summits of all 14 mountain peaks above 8,000m (26,247ft).

 But his career was blighted by a family tragedy just before Christmas 2001, when he killed his own infant son by shaking him to death to stop him crying.

 The two climbers fell for unknown reasons at a height of 3,800m, up the 4,043-m peak, police from the Swiss canton of Valais said.

 It was a fall of 200m, according to Swiss newspaper La Tribune de Geneve.

 Manslaughter conviction

 Loretan, originally from the canton of Fribourg, began climbing at the age of 11.

 He scaled his first 8,000-m peak, Nanga Parbat in Pakistan, in 1982.

 Over the next 13 years, he climbed the other 13.

 His 1986 ascent of Mount Everest, without bottled oxygen, by night and in just 40 hours, stunned the mountaineering world.

 That same year, he climbed 38 Swiss peaks in 19 days, La Tribune de Geneve reports.

 He told L'Objectif magazine in 1995 that he had an "extreme fear of death" but his fear kept him crucially alert when climbing.

 For the manslaughter of his son of seven months, Loretan was convicted and given a suspended sentence of four months in 2003.

 He said he had shaken the child for just a couple of seconds to stop him crying, then put him to bed and the crying had stopped. He later called an ambulance.

 The case's notoriety led to new research showing many parents were unaware that infants can die from being shaken for only a few seconds, because of weak neck muscles, the Associated Press news agency recalls. |||||


Here is a news article: Tweet with a location

 You can add location information to your Tweets, such as your city or precise location, from the web and via third-party applications. You always have the option to delete your Tweet location history. Learn more ||||| Yu Darvish says he isn't angry toward Yuli Gurriel, calling it a learning experience for Gurriel and adding that no one is perfect. (2:04)

 HOUSTON -- Astros first baseman Yuli Gurriel faces potential discipline from Major League Baseball for making a racially insensitive gesture Friday night during Game 3 of the World Series.

 After hitting a home run in the second inning off Los Angeles Dodgers pitcher Yu Darvish, Gurriel returned to the Astros dugout, where he used his fingers to motion at his own eyes in a mocking gesture and appeared to mouth a derogatory term in Spanish.

 In a statement, an MLB spokesman said: "We are aware of the situation and the Commissioner intends to speak with the player tomorrow."

 Speaking through an interpreter after the game, Gurriel said he made the gesture because he hasn't had success in the past against Japanese pitchers. In particular, he was 1-for-7 with one strikeout this season against Darvish.

 "I did not mean it to be offensive at any point," Gurriel said. "Quite the opposite. I have always had a lot of respect [for Japanese people]. ... I've never had anything against Darvish. For me, he's always been one of the best pitchers. I never had any luck against him. If I offended him, I apologize. It was not my intention."

 The 33-year-old Gurriel is a native of Cuba who played for the Yokohama DeNA Baystars of the Japanese Central League in 2014. Darvish is of Japanese and Iranian descent.

 Gurriel said it's common in Cuba to use the word "chinito" to describe someone of Asian heritage, although he admitted he realizes it's considered offensive in Japan.

 Darvish, also speaking through an interpreter, called the gesture and the word "disrespectful."

 "I feel like, of course, Houston has Asian fans and Japanese fans, and Asian fans live all over the place," Darvish said. "And acting like that, it's just disrespectful to people around the world, to the Houston organization. It's not OK.

 "Including him and I, nobody's perfect. Everybody's different. We've just got to learn from it. He made a mistake, and we've just got to learn from it. We are all human beings. It's just learn from it, and we've got to move forward."

 Astros manager A.J. Hinch described Gurriel as "remorseful." Most Astros players said they weren't aware that Gurriel had made a gesture or that they hadn't seen it.

 Dodgers outfielder Enrique Hernandez described the situation as "disappointing."

 "It's just unfortunate that he did that right after the homer and not thinking the cameras were on him," Hernandez said. "I'll let the league handle [potential discipline]. I'm not the right guy to handle that one."

 A source in the Dodgers organization said the team is "very upset" about the situation, "especially in these times in this environment."

 Darvish later tweeted a statement, saying people should put effort into "learning rather than to accuse [Gurriel]."

 "If we can take something from this, that is a giant step for mankind," Darvish wrote. "Since we are living in such a wonderful world, let's stay positive and move forward instead of focusing on anger. I'm counting on everyone's big love."

 Darvish played professionally in Japan from 2005 to 2011 before joining the Texas Rangers in 2012. He was traded to the Dodgers at this year's July 31 trade deadline.

 The Astros lead the series 2-1, with Game 4 set for Saturday at Minute Maid Park.

 ESPN's Marly Rivera and Ramona Shelburne contributed to this report. ||||| CLOSE Yu Darvish was hit early and often and the Houston Astros beat the Los Angeles Dodgers in Game 3 of the World Series. USA TODAY Sports

 Yuli Gurriel rounds the bases after hitting a solo home run in the second inning. (Photo: Thomas Shea, USA TODAY Sports)

 HOUSTON – The World Series was roiled by a race-related incident in Friday night’s Game 3 when Houston Astros first baseman Yuli Gurriel made a racist gesture in the wake of hitting a home run off Los Angeles Dodgers starter Yu Darvish.

 TV cameras caught Gurriel, a Cuban, making a slant-eyed gesture and laughing after his home run off Darvish kick-started a four-run second inning.

 Gurriel apologized afterward, saying he did not mean to offend Darvish, a native of Japan.

 MORE FROM GAME 3

 “Yesterday I was commenting that I’d never had any success against Darvish, and the gesture was saying that I wish he would look at me like one of them and maybe he’d throw me an easy pitch so I can do something,’’ said Gurriel, who was 1-for-7 in his career against Darvish before the home run. “At no point did I mean that in an offensive way. On the contrary, I’ve always had a lot of respect for them.’’

 Gurriel, who had a successful stint in the Japanese league in 2014 before defecting from Cuba and signing with the Astros in July 2016, also acknowledged using the word “chinito’’ – little Chinese guy – in the dugout in reference to Darvish.

 “In Cuba and in other places, we call all Asian people Chinese,’’ Gurriel said. “But I played in Japan and I know they find that offensive, so I apologize for that. I know they don’t like it.’’

 Darvish, the Japanese right-hander in his sixth major league season, said after the game that he'd seen a replay of the sequence and said he was “disappointed” in Gurriel’s gesture.

 "Acting like that…is disrespectful to people around the world," Darvish said through his interpreter after the Astros' 5-3 victory in Game 3. "I try not to care much about it, but he played in Japan and I have a lot of respect for him, so I try not to think about it too much against him."

 Darvish seemed subdued, but forgiving of Gurriel's gesture.

 "Nobody’s perfect. And everybody’s different," he says. " And we’re going to have to learn from it. We are all human beings. That’s what I’m saying. We’ll learn from it and we have to go forward."

 Dodgers teammate Kike Hernandez said he talked to Darvish about the incident and said Darvish was "extremely disappointed, as expected." Earlier this season, Toronto Blue Jays outfielder Kevin Pillar was suspended three games for directing a homophobic slur toward an opponent. It's not likely such a punishment would be adjudicated between Major League Baseball and the union during the World Series, but MLB has shown a greater intolerance for hateful speech.

 "I'll let the league handle that one," said Hernandez, a native of Puerto Rico. "All I can say it’s disappointing to me. It’s just unfortunate that he did that right after that and not thinking that the cameras were on him.

 "I’m sure (Darvish) is (stung). If it was meant toward Puerto Ricans, I’d be really disappointed. If he is really mad inside and didn't say much, I’m really proud of him for handling it the right way and remaining professional."

 MLB commissioner Rob Manfred is expected to meet with Gurriel before Saturday's game.

 Gallery: Best of the 2017 World Series |||||
A summary of this is?

– Yuli Gurriel of the Houston Astros hit a home run in the second inning off Dodgers pitcher Yu Darvish Friday night, giving him reason to celebrate in the dugout afterward. But Gurriel is now apologizing after cameras caught him taking things too far. The Cuban native can be seen making a slant-eyed gesture in regard to Darvish, who is from Japan. He also acknowledged using the word "chinto," meaning "little Chinese guy," reports USA Today. "At no point did I mean that in an offensive way," he said through an interpreter afterward. “Yesterday I was commenting that I’d never had any success against Darvish, and the gesture was saying that I wish he would look at me like one of them and maybe he’d throw me an easy pitch so I can do something." Darvish, for his part, called the gesture "disrespectful," but wasn't making a big deal about it. "I have a lot of respect for him," he said of Gurriel, who played for a while in Japan, "so I try not to think about it too much against him." Later, the pitcher tweeted: "Since we are living in such a wonderful world, let's stay positive and move forward instead of focusing on anger. I'm counting on everyone's big love." Gurriel could face league discipline, though it was unclear whether that might mean missing a World Series game. "We are aware of the situation and the commissioner intends to speak with the player," says a league spokesperson, per ESPN. The Astros won the game to take a 2-1 lead in the series.


Article:

A Clayton County teen who was abducted from her home early Tuesday morning is now back with her family.

 A neighbor told Channel 2 Action News she saw Ayvani Perez, 14, return to the family home in Ellenwood early Wednesday night.

 However, Channel 2 Action News has learned Ayvani did not spend the night at the home that she was abducted from nearly 48 hours earlier.

 Investigators announced in a new conference Wednesday that they had arrested Wildrego Jackson, 29, and Juan Alberto Rodriguez, 40, in connection to Ayvani's abduction.

 Police said two armed men broke into Ayvani's home early Tuesday and kidnapped her after asking her mother for money and jewelry.

 Police said Rodriguez and Jackson are not the same men that were pictured in the sketches investigators released on Tuesday.

 They said the men in the sketches are the ones that carried out the abduction, and they remain on the loose.

 "We believe those two suspects in the drawings are still at large," said Special Agent Rick Maxwell with the FBI.

 Clayton County Police Chief Greg Porter said Ayvani was in seemingly good health when police found her and she had been evaluated after police said they located her at a home in Conyers.

 Federal agents wouldn't say how they came to find Ayvani at the Conyers home.

 Porter said the suspects were captured "through hardcore police work."

 "I want to thank the community as a whole for supporting the Clayton County Police Department and all the collaborations between the agencies," Porter said.

 After digging into both men's criminal background, Channel 2 Action News learned there was a connection between one of the men arrested and Ayvani's mother, Maria Corral.

 ICE agents confirmed to Channel 2 Action News that Rodriguez was arrested in December 2012 in Henry County under the name of Juan Aberto Contreras-Ramirez, and was charged with trafficking marijuana.

 Channel 2's Erica Byfield confirmed that Ayvani's mother was also arrested in that same incident.

 Drug agents said they found 500 pounds of marijuana in the Henry County home where the Rodriguez and Ayvani's mother were arrested.

 Charges against both were later dropped but the case indicates this week's kidnapping may not be as random as authorities first believed.

 Rodriguez is currently being held on immigration-related charges. Jackson faces conspiracy to commit kidnapping charges.

 Channel 2 Action News dug into Jackson's record and found he has an extensive criminal background dating back to at least 2001.

 Records show multiple arrests through the years on charges that include assault, child cruelty, sale and distribution of cocaine, marijuana possession, and being a convicted felon in possession of a firearm. He was also arrested on obstruction charges.

 Neighbors told Byfield they are very happy the teen was returned safely.

 "We have just been praying as a community for her safe return and so I'm so excited," said neighbor Fran Pond.

 Pond said she doesn't know the girl but in the day and a half she saw Ayvani's picture all over the place, she felt a connection.

 "My heart goes out because I'm a mom, so my heart went out to her mom," Pond said.

 Lucille Howard lives two doors down from Ayvani and her family. Howard just moved to the seemingly quiet neighborhood three days ago. She made a point to hug the teen Wednesday evening shortly after Ayvani returned home safely.

 "Something like that really shook me up. But I'm going to find out more about this thing because some things don't make sense to me," Howard said. "She smiled, she gave me the biggest smile, she said thank you."

 Howard says the teen looked calm but tired and glad to be home. Now H oward and other neighbors have questions about the circumstances surrounding Ayvani's kidnapping

 "Just meeting her today, it doesn't matter what happened, since she is home safe. That's my main concern," Howard said. ||||| Just One More Thing...

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What is a summary?

– Authorities are still keeping quiet about just how they managed to find a kidnapped girl "at a residence" in Conyers, Ga.; they're calling it "hardcore police work," WSB-TV notes. In the meantime, however, new information is emerging about the circumstances of the kidnapping. One of the suspects had previously been arrested along with victim Ayvani Hope Perez's mother, the Atlanta Journal-Constitution reports. Juan Alberto Contreras-Ramirez—called as Contreras-Rodriguez in the kidnapping arrest—was nabbed in a 2012 drug trafficking case involving the seizure of 500 pounds of marijuana; Perez's mom, Maria Corral, and several others were also busted. Corral's charge was quickly dropped; in January, charges against Contreras-Ramirez were, as well, following a home search deemed unconstitutional. As for Corral, "I think she just happened to be in the wrong place at the wrong time," says Contreras-Ramirez's lawyer in the drug case. She was "talking in the driveway" with Contreras-Ramirez when the arrests occurred. As for Perez, "she looked tired, but not shaken up" upon arriving home, says a neighbor. "She was smiling. A look of relief was all over her."


The rate of developing esophageal squamous cell carcinoma (ESCC) nearly doubles in those who both smoke and drink compared to those who only smoke or drink, according to new research published in The American Journal of Gastroenterology. Although multiple studies have identified risk factors for the development of ESCC, notably, exposure to alcohol and tobacco, this research is the first meta-analysis to look at the interaction between alcohol and tobacco in the risk of ESCC, a class of esophageal cancer that begins in the flat cells lining the esophagus.

 "Our study suggests that not only do alcohol and tobacco play an important role in the development of esophageal cancer, the combination of their use markedly increases their potency as carcinogens. As a result, we as physicians should focus efforts directed at controlling the burden of esophageal cancer on those who consume both of these substances," said lead author Anoop Prabhu, MD, Advanced Endoscopy Fellow at the Icahn School of Medicine at Mount Sinai, in New York, NY.

 Dr. Prabhu, and authors Drs. Kenneth O. Obi and Joel H. Rubenstein at the University of Michigan Medical School, performed a systematic literature search in multiple electronic databases and looked at population-based case-control or cohort studies of ESCC that assessed the effects of tobaccos and/or alcohol. A synergy factor was calculated from each study to estimate the interaction on a multiplicative scale between tobacco and alcohol on the outcome of ESCC.

 "Our systematic review confirmed the expected exposure-dependent relationship of both alcohol and tobacco with the risk of ESCC, as alcohol use and tobacco use were both independent risk factors for the development of ESCC," stated Dr. Prabhu.

 According to the National Cancer Institute, it is estimated in 2014 there will be over 18,000 new cases of esophageal cancer in the United States, and over 15,000 deaths from the disease. ||||| "Grape or grain, but never the twain." So runs the old folk wisdom that advises against drinking wine or beer on the same night. It is far from uncommon to hear people who have woken up feeling sick, dehydrated and with a splitting headache blaming their hangovers on having unwisely mixed their drinks.

 Then there are the theories about the order in which to consume different tipples. One version suggests: “Wine before beer and you’ll feel queer. Beer before wine and you’ll feel fine.” Or is it the other way round? After a couple of drinks it’s not always easy to remember. All of which begs the question of how reliable these sayings are. Is there any evidence beyond the anecdotal that drinking wine followed by beer or vice versa makes hangovers worse?

 A review of previous research published in 2000 confirms that the causes of the main symptoms of hangovers are dehydration, changes in the levels of hormones such as aldosterone and cortisol, and the toxic effects of alcohol itself. In addition there’s evidence that the immune system is disrupted and that this could be the cause of the headache, the nausea and the fatigue.

 The first of the two main ingredients of a drink that affect the severity of a hangover is obvious. The higher the alcohol content, and the faster you drink it, the worse the hangover. This is however just an average. The same quantity of alcohol does not always result in the same severity of hangover. Many report that they don’t get hangovers and no one quite knows why. In a study of young Danes on holiday, almost a third of those who consumed at least 12 units of alcohol (roughly equivalent to four pints of lager or four 250ml glasses of wine) avoided hangovers.

 Mixing drinks needn’t necessarily increase the overall amount of alcohol consumed, but it may do with cocktails. If combining three or four measures of spirits alongside other ingredients, a throbbing head and dry throat is probably just the result of consuming more alcohol in total.

 Beyond the ethanol that triggers intoxication, the other key ingredients that affect hangovers are what the beverage industry calls congeners. These are the other substances produced during fermentation, such as acetone, acetaldehyde, fusel oil and the best-known, tannins, which give darker drinks their colour and part of their flavour. Bourbon whisky, for example, contains 37 times the quantity of congeners as vodka.

 To find out the effect of these substances on hangover severity, researchers in the US recruited university students who were regular drinkers, without alcohol problems. On different nights they were given either bourbon and cola, vodka and cola or a placebo which consisted of cola mixed with tonic, with a few drops of either bourbon or vodka to make it taste similar to the real stuff. They drank anything between three and six drinks, however much was enough to give them a concentration of 0.11g of alcohol per 100ml of breath. This would put them two to five times over the drink drive limit, depending which country they were in. They then spent the night in the clinic and were woken at 7am for breakfast before taking part in a battery of tests. For this they were paid a rather generous $450. The researchers found the students who drank bourbon rated their hangovers as worse, but interestingly they performed just as well on tasks such as reaction time tests.

 Clear drinks such as white rum, vodka and gin tend to cause fewer and less severe hangovers because they contain relatively low levels of congeners. Perhaps those who mix their drinks are more likely to choose a dark-coloured drink containing higher levels of these substances simply by virtue of their wider drinking range, but again it isn't the mixing in itself that causes the problem.

 No scientist seems to have done the perfect counter-balanced study where people are randomly assigned to drink beer followed by wine or wine followed by beer. But perhaps it’s not the grape or the grain that matters, but the effect that the strength of those drinks has on judgement. Beer is only between a third and half the strength of wine, so starting on it leads to less intoxication if followed by the stronger stuff. But if a person starts on wine or spirits, then their judgement may be impaired enough to drink more heavily later. There’s certainly evidence that people are not good at judging their own drunkenness. At low levels people overestimate the amount of alcohol in our blood, but after a few drinks they start to underestimate it.

 So, the existing evidence suggests that hangovers can't be blamed on mixing drinks. It's probably down to the high congener count of the booze, or over-drinking. As for hangover cures, scientists have looked into those too, and the British Medical Journal published a review of trials of everything from borage to artichoke and glucose to prickly pears in 2005. The bad news for drinkers is that none of them work.

 Do you agree? If you would like to comment on this, or anything else you have seen on Future, head over to our Facebook or Google+ page, or message us on Twitter. |||||

Write a summary.

– Many of us may avoid downing hard alcohol, wine, and beer on the same night for fear of a raging hangover the next day. But at the BBC, a review of existing research on the topic suggests the drinks' variety itself isn't the problem. Instead, Claudia Hammond points to other possible factors. For instance, she notes, having several different types of drinks may simply mean drinking more total alcohol. (As for "beer before liquor, never been sicker"? It appears no research has been done to prove or disprove the idea that drink order makes a difference.) "The existing evidence suggests that hangovers can't be blamed on mixing drinks," Hammond writes. But the amount of alcohol may not be the only culprit: Congeners, the non-ethanol products of the fermentation process, also contribute to a hangover. Tannins, for instance, are responsible for the color in darker types of alcohol. There are 37 times more congeners in bourbon than in vodka, and one study found that bourbon drinkers reported worse hangovers than those who drank vodka. So, Hammond writes, people having various types of drinks in a single night may end up indulging in drinks with more tannins. So go ahead and mix types of alcohol if you so desire, but you may want to avoid mixing alcohol with cigarettes: A study last month found that people who smoke and drink are at a higher risk of developing esophageal cancer, Science Daily reported. (If you do find yourself with a hangover, you may want to reach for a Sprite.)


Here is a news article: Robin Williams Widow and Kids Bitter Fight Over Property

 Robin Williams -- Widow and Kids in Bitter Fight Over Property

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 ' widow is fighting his 3 children over property the kids say is clearly theirs ... and the dispute is so bad it has ended up in court.has filed legal docs complaining someone came into the house days after Robin's death and took some of the actor's belongings. But the kids tell a very different story.andclaim Susan is essentially attempting a money grab by ignoring the plain language of his will and trust and trying to redefine it to benefit her.Sources connected with the kids tell TMZ ... Susan refused to let them in the house after Robin died. We're told before Robin met Susan -- he was very clear in the trust he created ... he left his personal effects, including his Oscar for the movie "", movie memorabilia, action figures, graphic novels, theater masks and other items to his 3 children.Susan -- who was only married to Robin for 3 years -- acknowledges she has no right to items related to his acting career, such as his suspenders from "," but she wants other items like the tux from his wedding and other "knickknacks."Sources connected with the children say Susan can absolutely keep the items she accumulated with Robin while they were married, but they say she has gone way further. For example, they're indignant she is apparently trying to redefine the word "jewelry." We're told the kids are supposed to get all of it, but she's saying "jewelry" does not include his watch collection.And people who were extremely close to Robin say he would be heartsick that this was not worked out between family ... privately. ||||| Nearly six months after the death of Robin Williams, the Academy Award-winning actor and comedian, his widow and his children have become engaged in a contentious legal dispute over his estate.

 Court documents filed in December and January outline a bitter disagreement over money and property between the widow, Susan Schneider Williams, who was Mr. Williams’s third wife, and Zak, Zelda and Cody Williams, the comedian’s children from two previous marriages that ended in divorce.

 At stake is not only a portion of the wealth that Mr. Williams accumulated in a film, television and stage career of some 40 years, but also cherished belongings that include his clothing, collectibles and personal photographs.

 In their court papers, both sides display keen interest in such memorabilia — everything from Mr. Williams’s bicycles to his collections of fossils and toys — as tangible, deeply personal reminders of the irrepressible, manic imagination that drove his performances as a comedian and actor. |||||
A summary of this is?

– In a sad but all-too-common postscript to someone's life cut short, Robin Williams' children and wife are locked in a bitter dispute over his estate. In court papers filed in December and January, the comedian's three adult children say they are "heartbroken" that widow Susan Williams is "challenging the plans he so carefully made for his estate" by trying to keep personal effects she's not entitled to, reports the New York Times. The children—Zak, Zelda, and Cody—are from two previous marriages, and they note that Susan was married to their father for "less than three years." They accuse her of adding "insult to a terrible injury" and say she refused to allow them in his Tiburon, Calif., home in the days after his death. Williams, who committed suicide in August, specified his estate go to his three children, but the dispute centers around a provision that the home, its contents, and enough cash to cover "all costs related to the residence" go to Susan Williams. The children accuse her of wrongly interpreting this to mean she can keep belongings she was never meant to have and of "greedily" trying to claim extra funds. Sources tell TMZ that the widow, who refers to Williams' collections of things like action figures and movie posters as "knickknacks," also argues that "jewelry" doesn't include things like watches. Her lawyer tells the Times that his client doesn't have "sticky fingers" and "compared to what the Williams children were set to receive from their father, this is a bucket of water in a lake."


Article:
“Sometimes I lost hope,” Faraj said. “I thought he was dead.”

 The 25-year-old rebel fighter had disappeared on the front lines of the battle on the eastern coast in March — after peaceful protests against Moammar Gaddafi turned into a war — joining the thousands of people missing in Libya.

 Many have been held for decades. Rebel leaders based here estimate that during the six-month-long conflict, nearly 60,000 more Libyans had disappeared. Even as they continue their search for Gaddafi, the rebels have opened his prisons in Tripoli, freeing thousands.

 But only about 10,000 prisoners have been accounted for, rebel leaders say, leaving families and friends to fear that thousands are in underground prisons or, perhaps, in mass graves.

 “Where in the world are they?” said Shamsiddin Ben-Ali, a spokesman for the Transitional National Council. “It’s a human crisis.”

 A family’s wait ends

 The Abu Salim facility in Tripoli, where Abdul Rauf was held for 48 days, was notorious within Gaddafi’s opaque prison system for its brutality, the place where many of his political opponents vanished.

 In 1996, after inmates at Abu Salim revolted over their living conditions, 1,200 of them were massacred. And it was the arrest in February of a lawyer representing the families of those killed in 1996 that helped spark the uprising, which started in Benghazi and spread across the country.

 After reuniting with his family members Sunday, Abdul Rauf told them that he was beaten and jabbed with electric prods every morning, from dawn until 10 o’clock, when he got a small piece of bread, some cheese, and, sometimes, a hard-boiled egg to share among six people. The first seven days, Abdul Rauf said, he was not allowed to use the bathroom and was given a bottle to use as a latrine.

 He shared a small cell with 70 people, all sleeping on the floor, and he told men who had been locked up for years what was happening outside the prison’s iron gates and towering walls.

 “There’s a revolution in the streets against Gaddafi. The people rose up,” he said he told them. The broken men finally had a glimmer of hope. They hugged him and wept, he said.

 At the airport Sunday morning, just after midnight, male relatives crowded around Abdul Rauf, kissing and hugging him. He said that he had been transferred to the Tajura prison, also in Tripoli, and that guards secretly working against Gaddafi unlocked cell and prison doors the day rebels converged on the capital last week.

 Neighbors stood at their gates waving as the young man rode past them with his father and uncle. Friends fired celebratory shots into the air. In the doorway of their home, his mother, Mariam Layas, and his sisters, Iman and Inas, waited in anticipation. When he entered the house, they showered him with kisses, hugs and tears while other female relatives cupped their hands over their mouths to trill with joy. ||||| Salahuddin, Libya (CNN) -- It's a harrowing story -- even by the standards of blood-soaked Libya.

 Muneer Masoud Own, 33, who made a living doing manual labor, said forces loyal to longtime Libyan leader Moammar Gadhafi slaughtered nearly 150 prisoners as rebels closed in on Tripoli last week.

 Charred bodies littered the ground around a warehouse -- roughly 30 feet by 45 feet -- where the detainees were kept. A volunteer who helped remove them, Bashir Own, estimated that he had seen about 150 bodies. He is not related to Muneer Own, who said he barely escaped an ordeal that started about a month ago.

 In early August, Muneer Own said, he and his 30-year-old brother were walking toward their grandfather's home when pro-Gadhafi forces detained them for reasons that were not explained. He said they were handcuffed, blindfolded and put into a warehouse with about 60 others who ranged in age from 17 to 70.

 Over the next 18 days, Gadhafi's forces kept bringing detainees, Own said. Soon, about 175 people were crammed inside the warehouse, near the headquarters of the Libyan military's 32nd Brigade -- a much-feared unit led by one of Gadhafi's sons, Khamis.

 Own said he endured horror and deprivation in the warehouse.

 "I don't know how I survived those moments. They were abusing us and beating us," Own said. "All I was thinking of was going home. I was dreaming of freedom."

 In the three days before he made his escape even as others around him were killed, the detainees had no food or water, Own said. The warehouse filled with the stench of human waste.

 Then, suddenly, Own and the others found a reason to hope: Guards said they would soon release everyone. It was all they talked about for a day or so.

 Just before sunset on the promised day of release, guards opened the warehouse doors, Own said, but the door did not lead to freedom. He said the guards tossed a grenade into the warehouse and started shooting.

 Dozens fell dead.

 Own ran for his life. He said about two dozen others managed to escape, but he lost track of his brother in the chaos. He has not heard from his brother since that day, he said, and assumes that he did not survive.

 When rebels finally took over the base and residents felt safe enough to approach the warehouse, all they found were charred remains. Volunteers said they pulled out at least 150 bodies, the majority of them unrecognizable.

 In another corner of the lot, piles of dug-up earth teemed with maggots. More bodies were found there.

 People found a handful of papers that could help identify the victims, but no one is sure. Many of the victims may remain unknown, their families left without answers to their fate. |||||Summary:

– Troops loyal to Moammar Gadhafi massacred some 150 detainees last week, according to volunteers who cleared charred bodies from the warehouse that had apparently served as the detainees’ prison. An escaped prisoner told his story to CNN: He and his brother were handcuffed and blindfolded for no apparent reason while out walking earlier this month. They were thrown into the warehouse with 60 others ages 17 to 70. The number inside quickly reached 175 as loyalists continued to imprison people. The detainees were given no food or water for days, said Muneer Own. Finally, the troops said they would set them free—but instead hurled a grenade at them and opened fire. About 25 people were able to escape, Own said; his brother apparently was not one of them. The mass of bodies was discovered when rebels eventually took over the area. Many remain unidentified, part of a growing number of prisoners whose whereabouts remain unknown, notes the Washington Post. Thousands—some of whom have been jailed for decades—could be in underground prisons or mass graves, rebels fear. Click through for one family’s story.


Here is a news article: “Sausage Party” scored at the box office this weekend, debuting to a meaty $33.6 million and providing a much-needed win for struggling Sony Pictures. In a summer dominated by spinoffs and reboots, the story of a gang of grocery items grappling with the dangers of the kitchen was an antidote to sequelitis and a reminder of the power of original ideas.

 “It was the something different that adult audiences have been craving,” said Jeff Bock, an analyst with Exhibitor Relations. “When comedy pushes the envelope, that’s when it works best.”

 In the case of “Sausage Party,” which liberally deploys sex jokes and four-letter words, it’s a foul-mouthed affair that more than earns its R rating. The $19 million animated comedy was also backed by Annapurna Pictures, the maker of “The Master” and “American Hustle.” Seth Rogen, Kristen Wiig, Edward Norton, Jonah Hill and Bill Hader are among the vocal cast members. The studio released “Sausage Party” in 3,103 locations, and it now holds the record for the largest August opening ever for an animated film.

 “When you have something so fresh, it just stands out to audiences,” said Rory Bruer, Sony’s distribution chief. “People were blown away by the movie. It’s outrageous, off-the-wall fun.”

 Related ‘Suicide Squad’ Is a Hit, But DC Needs to Start Making Better Movies

 It’s good news for Sony, which has had a bruising period at the multiplexes. Flops such as “Ghostbusters,” “Pride and Prejudice and Zombies” and “The 5th Wave” have outweighed hits such as “The Shallows” and “The Angry Birds Movie.” It gives Sony momentum as it tries to put its recent bad run behind it and prepares for a fall and winter that will bring the debuts of “The Magnificent Seven” with Denzel Washington and “Passengers” with Chris Pratt and Jennifer Lawrence.

 And then there are victories that feel more like defeats. “Suicide Squad” topped domestic charts with $43.8 million, bringing its stateside total to a hefty $222.9 million. However, that represented a punishing 67% slide in the superhero movie’s second week business, nearly equaling “Batman v Superman: Dawn of Justice’s” 69% sophomore plunge. It’s a signal that the deplorable reviews are catching up with the film and is unwelcome news for Warner Bros., which is trying to launch an inter-connected series of cinematic adventures based on DC Comics characters, but is still struggling to make movies that people like, as well as attend.

 The weekend’s other major new release, Disney’s “Pete’s Dragon,” faltered, mustering roughly $21.6 million from 3,702 locations, despite scoring glowing reviews. The remake of the 1977 family film about a boy who befriends a dragon stars Robert Redford and Bryce Dallas Howard. “Pete’s Dragon” snagged third place on the charts. It cost $65 million to make, making its opening a disappointment. Still, Disney believes that it could ultimately make a profit when its foreign grosses are factored into the picture.

 “We’re going to come out of this having made money,” said Dave Hollis, Disney’s distribution chief. “People who are coming out of the theater are just loving it and their advocacy is going to help us put together a nice, solid run.”

 Coming in fourth, Universal’s “Jason Bourne” added $13.6 million to its haul, pushing its domestic total to $126.8 million. STX Entertainment’s “Bad Moms” rounded out the top five with $11.4 million. The raunchy comedy has been a breakout hit for the new studio, earning $71.5 million to date on a $20 million production budget, and holding well on a week-to-week basis despite the presence of several summer tentpoles.

 Paramount debuted “Florence Foster Jenkins,” a comedy about an off-key opera singer and heiress (Meryl Streep) who rents out Carnegie Hall for a public performance, in 1,528 locations. The film did a muted $6.6 million worth of business, and appealed primarily to older audiences, with 97% of its opening weekend crowd clocking in over the age of 25.

 “Word-of-mouth is definitely going to be our friend,” said Megan Colligan, Paramount’s president of worldwide distribution and marketing. She added that the studio is confident that Streep and possibly her co-star Hugh Grant could end up in the hunt for awards, something which could goose revenues.

 “This is very much in line with the Academy’s sensibilities,” said Colligan.

 In limited release, Bleecker Street launched the World War II thriller “Anthropoid” in 452 theaters, earning $1.2 million.

 CBS Films scored with “Hell or High Water,” a bank heist picture that earned critical raves at the Cannes Film Festival. The thriller picked up an impressive $592,000 from 32 locations for a per screen average of $18,500. The studio partnered with Lionsgate on the distribution. It expects to keep expanding the film, which stars Chris Pine and Jeff Bridges, in the coming weeks.

 Total receipts were up nearly 15% from the year-ago period — a weekend that saw the release of “Straight Outta Compton” and “The Man From U.N.C.L.E.” Analysts said that August has now become a hospitable launching ground for films such as “Sausage Party” that deviate from Hollywood’s current franchise mentality. It has hosted the likes of “Inglourious Basterds,” “Superbad” and “Guardians of the Galaxy,” among other off-beat hits.

 “August is the time when the studios take off the gloves,” said Paul Dergarabedian, senior media analyst at comScore. “It’s not a time to play it safe.” ||||| Skip in Skip x Embed x Share An unlikely team of supervillains must save the day.

 Jai Courtney and Karen Fukuhara were among the 'Suicide Squad' baddies. (Photo: Warner Bros. Pictures)

 The hot dogs of the animated comedy Sausage Party cooked up a sizzling debut yet were ultimately shot down by the bad guys.

 Suicide Squad, the latest in the DC Films series, was No. 1 for a second weekend in a row with $43.8 million, according to studio estimates from comScore. It's good news and bad news for the comic-book film: That's a brutal 67% drop from its August-record $133.7 million opening, but the 10-day domestic total is $222.9 million for the supervillain-centric affair.

 Even with the diminishing returns and scathing reviews, Squad has made $465.4 million globally and should be considered a success, says comScore senior media analyst Paul Dergarabedian. "It may not be an emotional hit with critics and some of the fans, but it's certainly a box office hit."

 Jeff Bock, senior box office analyst for Exhibitor Relations, agrees. "What Warner Bros. and DC did was give audiences something that obviously they really wanted to see. This is a band of outsiders rolling up one of the top 20 debuts of all time. This is a big thing still, no matter how it breaks down."

 Sausage Party, an R-rated raunch-fest featuring the voices of Seth Rogen, Kristen Wiig and others as food products, racked up $33.6 million to come in at No. 2. The film managed a B Cinemascore from audiences, but critics approved — Party is rocking an 82% approval rating on the review-aggregate site RottenTomatoes.com.

 "Early on, everybody was marginalizing this movie because it looks like this frivolous ... concept, but audiences love original content if it's packaged the right way and if it's truly funny," Dergarabedian says.

 (Photo: Courtesy of Sony Pictures)

 In third place was the Disney family remake Pete's Dragon, starring Bryce Dallas Howard as a forest ranger who takes in a boy (Oakes Fegley) whose best friend is a giant green dragon. Its $21.5 million debut is the latest in a string of live-action kid-friendly movies that have struggled at the box office, though it played well with audiences (A Cinemascore) as well as critics (85% on Rotten Tomatoes).

 "That's a head-scratcher," Deregarabedian says. "It would seem in the midst of all this edgy material that Pete's Dragon would be a sanctuary for families."

 The heartwarming family films along the lines of Pete's and Steven Spielberg's The BFG "just aren't doing the business at the box office anymore," Bock adds. "Maybe that's just the sea change of where we are right now."

 The Matt Damon action movie Jason Bourne ran its domestic total to $126.8 million with a $13.6 million weekend — good enough for fourth place. Rounding out the top five is the comedy Bad Moms with $11.5 million.

 (Photo: Disney)

 The only other major movie out this week, Florence Foster Jenkins, earned $6.6 million. Starring Meryl Streep as a 1940s New York socialite with dreams of being an opera singer, the dramedy managed an A-minus Cinemascore and 86% at Rotten Tomatoes.

 In limited release, the Western heist film Hell or High Water — brandishing Jeff Bridges, Chris Pine and an astounding 99% on Rotten Tomatoes — rode tall in 32 theaters with $592,000, an $18,500-per-screen average. "It certainly made its presence known," Dergarabedian says, "and I think will do better as it expands to more theaters and offers up something original."

 Final figures are expected Monday.

 Read or Share this story: http://usat.ly/2bhpeVv |||||
A summary of this is?

– In case anyone wondered whether Seth Rogen could make what amounts to a movie-length penis joke and get people to flock to it, the answer is yes. Sausage Party scored this weekend with a solid $33.6 million debut, reports Variety. That wasn't enough to unseat Suicide Squad, which USA Today notes chalked up a $43.8 million win that was nevertheless "a brutal 67% drop from its August-record $133.7 million opening." Coming in third was Pete's Dragon, with a lackluster $21.6 million debut. And rounding out the top five were Jason Bourne with $13.6 million and Bad Moms with $11.5 million.


Image copyright Reuters Image caption The chief neuroscientist at the hospital in Rennes said there was no known antidote to the drug

 One man is brain-dead and another five people are in hospital after an experimental drug was administered to 90 people in a French clinical trial.

 There is no known antidote to the drug, the chief neuroscientist at the hospital in Rennes said.

 Of the six men in hospital, three could have permanent brain damage, Gilles Edan added.

 Reports that the drug is a cannabis-based painkiller have been denied by the health ministry.

 A fifth man is suffering from neurological problems and a sixth man is being monitored but is not in a critical condition, Mr Edan said.

 The trial, which involved taking the drug orally and has now been suspended, was conducted by a private laboratory in Rennes.

 The experimental drug was manufactured by the Portuguese company Bial.

 All those who volunteered for the trial have been recalled and the Paris prosecutor's office has opened an investigation.

 Health Minister Marisol Touraine pledged to "get to the bottom... of this tragic accident".

 "I was overwhelmed by their distress" she told reporters. "Their lives have been brutally turned upside down".

 Analysis

 By James Gallagher, health editor, BBC News website

 This is the bitter price of the new medicines we take for granted. Testing such experimental drugs, at the cutting edge of science, can never be completely risk-free.

 The safety and effectiveness of these drugs are rigorously tested in animals. The risks are low but there must still be a leap of faith when they are tried in people for the first time.

 This trial has been taking place since July without such major events being reported. Generally in Phase I trials the dose is increased slowly over time, which could be why the side-effects are appearing now.

 The hospitalised men started taking the drug regularly on 7 January and began showing severe side-effects three days later.

 Three of the volunteers are now facing a lifetime of disability in this "accident of exceptional gravity".

 It is a high price to pay, but thousands of people do safely take part in similar trials each year.

 The trial was conducted by Biotrial, a French-based company with an international reputation which has carried out thousands of trials since it was set up in 1989.

 In a message on its website, the company said that "serious adverse events related to the test drug" had occurred.

 The company insisted that "international regulations and Biotrial's procedures were followed at every stage".

 According to the health ministry, the adverse effects occurred on Thursday.

 Clinical trials

 Trials typically have three phases to assess a new medicine for safety and effectiveness

 Phase I tests for safety. A small number of people, sometimes healthy, and sometimes with a medical condition, are given a tiny dose of the drug under careful supervision, not to test if the drug works, but in order to check for any side effects

 Phase II sees the drug given to people who have a medical condition to see if it does indeed help them

 Phase III trials are only for medicines or devices that have already passed the first two stages, and involve them being compared to existing treatments or a placebo. The trials often last a year or more, involving several thousand patients

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 The study was a Phase I clinical trial, in which healthy volunteers take the medication to evaluate the safety of its use, the ministry said.

 Before any new medicine can be given to patients, detailed information about how it works and how safe it is must be collected.

 Image copyright AFP Image caption Health Minister Marisol Touraine travelled to Rennes to monitor the incident

 Clinical trials are the key to getting that data - and without volunteers to take part in the trials, there would be no new treatments for serious diseases such as cancer, multiple sclerosis and arthritis.

 Every year around the world thousands of people take part in clinical trials but incidents like this are very rare, the BBC's Hugh Schofield reports from Paris.

 New EU regulations to speed up clinical drug trials and streamline testing procedures across the 28-nation bloc are due to take effect in 2018. ||||| One person is brain dead and five others are seriously ill after taking part in a drug trial for Portuguese pharmaceutical firm Bial at a clinic in north-west France.

 The French health ministry said the six male patients aged 28 to 49 had been in good health until taking the oral medication. They started taking the drug on 7 January. One person started feeling ill on Sunday and the other five afterwards. The brain dead volunteer was admitted to hospital in Rennes on Monday. Other patients went in on Wednesday and Thursday.

 Pierre-Gilles Edan, head of the hospital’s neurology department, said one man was brain dead, three others were suffering a “handicap that could be irreversible” and another had neurological problems. The sixth volunteer had no symptoms but was being monitored.

 The French health minister, Marisol Touraine, said 90 people in total had taken part in the trial and received some dosage of the drug; others had taken a placebo. All trials on the drug have been suspended and all volunteers who have taken part in the trial are being called back.

 The ministry said the test was carried out by the Biotrial clinic for Bial, which “specialised in carrying out clinical trials”.

 The trial was intended to test for side-effects of the new drug but all trials at the clinic have been suspended and the French state prosecutor has opened an inquiry.

 Touraine said the drug was a so-called FAAH inhibitor meant to act on the body’s endocannabinoid system, which deals with pain. Earlier reports suggested that the drug contained cannabinoids, an active ingredient found in cannabis plants, but the minister said it did not contain the drug or any derivatives of it.

 Touraine said the study was a phase one clinical trial, in which healthy volunteers take the medication to “evaluate the safety of its use, tolerance and pharmacological profile of the molecule”.

 Medical trials typically have three phases to assess a new drug or device for safety and effectiveness. Phase one entails a small group of volunteers and focuses only on safety. Phase two and three are progressively larger trials to assess the drug’s effectiveness, although safety remains paramount.

 Testing had already been carried out on animals, including chimpanzees, starting in July, Touraine said.

 Bial said it was committed to ensuring the wellbeing of test participants and was working with authorities to discover the cause of the injuries, adding that the clinical trial had been approved by French regulators.

 Every year, thousands of volunteers, often students looking to make extra money, take part in such trials. Mishaps are relatively rare, but in 2006 six men were treated for organ failure in London after taking part in a clinical trial into a drug developed to fight auto-immune disease and leukaemia.

 The men now apparently have a higher risk of cancer and autoimmune diseases tied to their exposure to the experimental drug.

 Dr Ben Whalley, a neuropharmacology professor at Britain’s University of Reading, said standardised regulations for clinical trials were “largely the same” throughout Europe. “However, like any safeguard, these minimise risk rather than abolish it,” Whalley said. “There is an inherent risk in exposing people to any new compound.”

 Agence France-Presse contributed to this story

  ||||| PARIS (AP) — Rennes chief neurosurgeon Gilles Edan says three of the 6 men hospitalized over a botched clinical drug trial in France could have "irreversible" brain damage.

 Speaking Friday at a press conference in the western French city of Rennes, Edan said one man is brain dead and four others have "neurological problems" — of which three could have permanent damage. Another man is being kept in the hospital, but is in a less critical condition.

 Health Minister Marisol Touraine says all the men were healthy before they volunteered for the drug trial. She urged calm and said no drug currently on the market was implicated in the failed trial. |||||

Write a summary.

– A drug trial in France has gone horribly wrong, leaving one healthy volunteer brain-dead; three other men may have suffered irreversible brain damage, another has "neurological problems," and a sixth is hospitalized with less severe problems, reports AP. Details on what happened, including what drug was being tested and its manufacturer, remain under wraps. One thing that is known: No treatment is available. Early reports in France suggested it was a cannabis-based painkiller, reports the Guardian, but the health ministry has denied that. The AP describes it as some kind of "painkiller compound." Testing was being conducted by the French company Biotrial, a veteran player in the industry, at a clinic in Rennes. All 90 volunteers who took the drug were healthy before the trial started, reports the BBC. Those hospitalized range in age from 28 to 49 and began taking the drug on Jan. 7. Health Minister Marisol Touraine promised to "get to the bottom... of this tragic accident" and said she's been "overwhelmed" by the tragic turn for participants. "Their lives have been brutally turned upside down." The study had been in phase one, in which volunteers take the drug orally to evaluate its effectiveness and side effects. A message on Biotrial's website states that "serious adverse events" occurred and says that international regulations "were followed at every stage throughout the trial, in particular the emergency procedures for the transfer of subjects to the hospital."


Write a summary based on this article:

(CNN) The live-action "family movie" has become an especially elusive commodity, especially now that every member has distinct programming options on a variety of screens. Disney largely threads that needle with "Christopher Robin," a movie that -- once it gets going -- should entertain kids with the antics of Winnie the Pooh and company, while for parents squiring them, spending time with that beloved, silly old bear is no bother at all.

 Director Marc Forster has an eclectic resume -- including a Bond movie and "World War Z" -- but the key entry for these purposes is "Finding Neverland," his moving 2004 look at Peter Pan creator J.M. Barrie.

 Throw in a spoonful of "Mary Poppins" for good measure, and you have "Christopher Robin," which doesn't rise to that level. Yet as with that earlier movie, the universal plot is all about an adult accessing his inner child, having lost touch with that pure, unadulterated side of himself.

 Introduced as a lad cavorting with his plush pals, Christopher is quickly shown getting shipped off to boarding school, growing up into Ewan McGregor and getting married (Hayley Atwell plays his wife, making the most of a relatively small role).

 Now, however, he's got adult-sized responsibilities, which include finding time for his own daughter. Having survived World War II, he's working for a large luggage company, but thanks to his officious boss (Mark Gatiss), faces arduous hours and the unsettling prospect of slashing jobs to make ends meet.

 Read More ||||| The world of Winnie-the-Pooh is given an appealing new spin in “Christopher Robin,” Disney’s latest bid to reassert the relevance of A.A. Milne’s quaint kid-lit icon. On its face, the live-action film comes across as a chance to watch Ewan McGregor infuse an adult, critter-harried Christopher with his sly comedic edge. It’s surprising to see how straight McGregor plays it for director Marc Forster (the J.M. Barrie portrait “Finding Neverland”), allowing the CG-animated Pooh and friends to endearingly steal the show.

 Aside from its title and tweedy period aesthetic, this fictional confection doesn’t have much in common with last year’s indie Milne-and-son biopic “Goodbye Christopher Robin.” Both stories might show us a grown-up Christopher impatient to be done with the old bear’s silliness, but here the issue is something altogether more fanciful than pesky literary legacy.

 McGregor’s character is a beleaguered mid-management drone in post-World War II London, thanklessly toiling for a luggage manufacturer — as opposed to dealing with “baggage,” which presumably would’ve been too on-the-nose. He’s an overly serious sort forever caught between his uncaring boss (Mark Gatiss, the BBC’s “Sherlock”) and his wistfully neglected perfect family. (Underutilized Hayley Atwell, of “Captain America,” seems cast mostly for her period look as Christopher’s wife; Bronte Carmichael is capably cute as the couple’s little girl.)

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 In the midst of Christopher’s latest work crisis, Pooh reenters his life, magically whisked to the city from the Hundred Acre Wood on a particularly rambling honey quest. True to his boyhood promise, Christopher hasn’t forgotten Pooh with time. But he has no time for him, and promptly escorts his old playmate home — a little too comically conspicuously for comfort — so that beans can be counted and ledgers balanced.

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 The lessons McGregor’s stress case learns while off in the countryside are gently predictable: The forest’s gloomy new emptiness directly reflects what Christopher is feeling. He really ought to be spending time with his family at their wood’s-edge retreat, where they’ve reluctantly gone without him.

 What’s so satisfying about these telegraphed messages is the earnest, old-fashioned charm that McGregor and longtime Pooh voice actor Jim Cummings bring to them. The CG animals’ designs even look to E.H. Shepard’s vintage book illustrations as a template rather than previous, sleeker Disney incarnations.

 Meanwhile, voice cast additions such as Brad Garrett and a group of five writers (“Spotlight” filmmaker Tom McCarthy among them) lend the toy menagerie a contemporary flair that’s funny without being obtrusive. When Garrett’s Eeyore mutters, “Don’t get me started,” you don’t want him to stop.

 ★★★

 CHRISTOPHER ROBIN

 Directed by Marc Forster. Written by Alex Ross Perry, Tom McCarthy, and Allison Schroeder, from a story by Mark Steven Johnson and Greg Brooker. Starring Ewan McGregor, Hayley Atwell, Bronte Carmichael, Jim Cummings, Brad Garrett. At Boston theaters, West Newton, suburbs. 104 minutes. PG (action). ||||| Few things will break you out of a rut and get your mind right faster than having a friend you haven’t seen in 30 years show up in your yard, unannounced, without wearing any pants.

 Christopher Robin (Ewan McGregor) with his long time friend Winnie the Pooh in Disney’s live-action adventure "Christopher Robin." Disney

 Christopher Robin (Ewan McGregor) with his long time friend Winnie the Pooh in Disney’s live-action adventure "Christopher Robin." Disney

 Piglet, Pooh, Rabbit, Roo, Kanga, Tigger and Eeyore in Disney’s live-action adventure "Christopher Robin." Disney

 Eeyore, Pooh and Piglet in Disneyâ€™s live-action adventure CHRISTOPHER ROBIN.

 Few things will break you out of a rut and get your mind right faster than having a friend you haven’t seen in 30 years show up in your yard, unannounced, without wearing any pants.

 That’s pretty much how Winnie the Pooh operates, though — with a combination of wide-eyed innocence and behavior that would land anyone else in jail or a mental ward — throughout Disney’s “Christopher Robin.”

 It’s a movie every bit as messy as its “hunny”-craving bear, though only somewhat as lovable.

 The titular storybook hero (Ewan McGregor), having grown up and survived World War II since leaving the Hundred Acre Wood for boarding school all those many years ago, is now the harried efficiency manager at a London luggage company.

 His wife, Evelyn (Hayley Atwell), hasn’t seen him laugh in years, and his 9-year-old daughter, Madeline (Bronte Carmichael), is desperately looking forward to a weekend at Christopher’s childhood cottage, where she’ll get to play where he once played before she, too, is shipped off to boarding school.

 Christopher’s boss, however, has other intentions. The company is struggling, and if Christopher can’t come up with a cost-cutting plan to save it over that very weekend, he may not have a job come Monday.

 Just as Evelyn and Madeline are leaving Christopher behind for the country, Pooh (Jim Cummings, in his 30th year of voicing the bear) realizes that all of his friends are missing from the Hundred Acre Wood. Since Christopher Robin has taken on an almost mythical resonance since they’ve seen him, Pooh goes looking for his help — by walking inside a tree and popping out in the middle of London.

 Pooh, along with the primary characters of Eeyore (Brad Garrett), Tigger (Cummings again) and Piglet (Nick Mohammed), are brought to life, seams and all, with a heavy dose of movie magic — and just a touch of creepiness. The initial effect isn’t that far removed from those nightmares where your stuffed animals come alive after you’ve gone to sleep. McGregor is as game as any actor for the role, but given his resume, it’s easy to think the whole talking toys thing is merely a hallucination and you’ve accidentally stumbled into the “Winnie the Pooh”-“Trainspotting” mashup you never knew you wanted.

 Directed by Marc Forster (“Finding Neverland”) from a script by Alex Ross Perry, “Spotlight” Oscar winner Tom McCarthy and Allison Schroeder (“Hidden Figures”), “Christopher Robin” feels like two drastically different movies grafted onto each other.

 Oh, bother.

 For the first hour or more, it’s a somber, artsy meditation on lost childhoods and being outgrown.

 The Hundred Acre Wood is downright gloomy. We first meet Eeyore (a terrific use of Garrett’s laconic baritone) as he’s floating down a stream toward a waterfall, ready to end it all. When Christopher snaps and tells Pooh he hasn’t thought about him since childhood, the response — “We think about you every day,” in Pooh’s doddering-old-man whisper — evokes all of the feels.

 The last half hour or so, though, is a madcap romp through London that’s clearly aimed at the child behind me who’d become so disengaged early on, his dozen or more loud queries sent me scurrying to a faraway seat.

 The end result may be discordant, but both ideas are enjoyably strange.

 “Sometimes when I’m going somewhere and I wait,” Pooh says, doling out some of his famous wisdom, “somewhere comes to me.”

 Given the abrupt change in tone, the makers of “Christopher Robin” didn’t seem to have much faith in where their film was going.

 It’s impossible to tell if somewhere came to them.

 But “Christopher Robin” still is worth “oh, bother”-ing to see.

 Contact Christopher Lawrence at clawrence@reviewjournal.com or 702-380-4567. Follow @life_onthecouch on Twitter. ||||| One of the problems with “Christopher Robin” is right there in the title. Compared to his stuffed playthings, Christopher Robin is the least memorable character in the Hundred Acre Wood-set tales penned by A.A. Milne and illustrated by E. H. Shepard. And we don’t even get him as the imaginative, precocious child overlord of Milne’s stories. Instead, Christopher appears in the guise of 47-year-old Ewan McGregor, a man who, in his own words, has not thought about his old pal Winnie-the-Pooh in thirty years. So why does Pooh, a figment of Christopher’s young imagination, return to him after all these years? Because Disney wants your money, of course. I don’t begrudge their need for greed; I just wish they hadn’t given us yet another movie built on the pseudo-psychological cliché that adults need to reconnect with their childhoods in order to be better adults.

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 After a brief recap of the most famous moments in Pooh’s history, “Christopher Robin” settles into the present day. Pooh and his friends are living their best lives in the Hundred Acre Wood. They have accepted that Christopher has grown up and moved on to London. We see Pooh change from his pajamas into his familiar and very short red shirt (it’s odd that he wears more clothes to bed than he does when he’s roaming the streets, but I digress). Armed with his usual hungry tummy rumble, Pooh sets off to mooch hunny from his friends, only to find that everyone has mysteriously disappeared.

 Meanwhile, in the adult world, we learn that Christopher has grown up, gotten married to a woman named Evelyn (Hayley Atwell) and had a daughter name Madeline (a very good Bronte Carmichael). He works a miserable job in Winslow Luggage Factory and is shown to be a World War II veteran. Whoever thought it was a good idea to put violent war footage of the main character into a children’s film must know more about feel-good kiddie films than I do. But again, I digress.

 I dawdle because I don’t want to tell you that Christopher is a rather horrible person. He’s a workaholic who neglects his kid and frowns on any notion of playtime she may be harboring. (His idea of bedtime reading involves history books, not “Treasure Island.”) Despite her pleas, he intends to ship her off to boarding school. Making matters worse, Chris’ marriage is on the rocks because he and Evelyn are not doing that thing I can’t talk about in a review of a children’s movie. Worst of all, the luggage factory is failing financially due to lack of travel after the war, so Christopher must fire a good portion of the factory workers. This last item prevents him from going away for the weekend with his family, who is so used to his broken promises that they don’t even pack him a suitcase.

 For reasons unexplained, Pooh needs Christopher to help him find his friends Piglet, Eeyore, Rabbit, Owl, Tigger, Kanga and Roo. So when he shows up in London, having gone through Christopher’s tree in the Hundred Acre Wood, his former benefactor thinks he’s losing his mind. Once he’s accepted the situation, however, Christopher Robin sees Pooh as another problem he doesn’t have time to solve. But unlike Paddington Bear (whose movie is one of this year’s best), Pooh isn’t going to last 45 seconds in London. So Christopher Robin has to personally deliver him back to the Hundred Acre Wood, which requires returning to the same old house where Madeline and Evelyn are vacationing.

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 The travel scenes, and the return visit to the Hundred Acre Wood, are pleasant enough, with McGregor doing a fine job of credibly selling the reunion between him and his stuffed pals. Each of your favorite characters is brought to life in special effects I thought looked exceptionally creepy, but your mileage may vary. Their personalities remain intact, and McGregor interacts with each of them with an admirable amount of happiness and joy.

 This joy is short-lived, of course, because adulthood isn’t all fun and games. In fact, it stinks on ice. Christopher Robin has major league problems that the childlike, innocent Pooh and his crew are just not equipped to handle let alone supplement. That’s my biggest issue here. As a kid, the last thing you probably wanted during playtime was for it to be invaded by adults. Even though the characters are pulled into Christopher’s real-life universe, it feels as if reality has invaded the Hundred Acre Wood and sullied it. The film’s Madeline-led climax, a mad race to save Christopher’s ability to fire people, feels like a case where the children have to raise the adults.

 By now, you’re probably saying I should just change my name to OdiEeyore Henderson. And I’m fine with that, because I love Eeyore. He was my favorite character as a kid. My mother used to say I had the hyperactivity of Tigger and the miserableness of Eeyore, which is the nicest thing anyone has ever said about me. My partner in attitude is rendered magnificently by the voice of Brad Garrett. As Eeyore, he gets the best lines, which I would expect from a script co-written by misery specialist Alex Ross Perry, and Garrett digs into them with a hilarious mixture of pathos and pessimism. And Jim Cummings’ voice-work as Pooh is also superb, a warm and cozy nostalgic throwback to Sterling Holloway that’s as comforting as Pooh’s favorite food.

 Back in 1991, Steven Spielberg’s “Hook” tried to bring a grown Peter Pan, and all his adult problems, back to Neverland. It was a bad idea despite the fact that Neverland is well-matched with the more messed up parts of the adult male psyche. By contrast, the Hundred Acre Wood—Heffalumps notwithstanding—felt safer and more immune to intrusions from scary adulthood. Even at its most amusing—and there are moments when it is downright hilarious—“Christopher Robin” can’t reconcile its darkness and its light. But if these folks want to write an Eeyore movie that stays firmly planted in the Wood, I’ll be first in line to see it. |||||

– Disney's Christopher Robin sees its adult namesake (Ewan McGregor) reunited with his childhood friend Winnie the Pooh (Jim Cummings) outside the Hundred Acre Wood and just in time, as life in post-World War II London is pretty gloomy. What critics are saying about Marc Forster's latest: "It's a movie every bit as messy as its 'hunny'-craving bear, though only somewhat as lovable," writes Christopher Lawrence at the Las Vegas Review-Journal. As it meshes "a somber, artsy meditation on lost childhoods" with a second half meant to engage kids, "the end result may be discordant … but Christopher Robin still is worth 'oh, bother'-ing to see," he writes. Tom Russo at the Boston Globe calls it "an appealing new spin" on Winnie the Pooh's world. Appearing much like the vintage book illustrations by EH Shepard, "the CG-animated Pooh and friends… steal the show," he writes, noting the script adds "a contemporary flair that's funny without being obtrusive." "Younger kids might grow a bit fidgety" as the film "gets off to a somewhat slow start," writes Brian Lowry at CNN. Once it gets going, though, it offers "a genuine sweetness" and serves as "a reminder of the simple pleasures of hanging out with family and a talking bear, which, in these frenetic times, is the kind of silliness that's worth savoring." But Odie Henderson could've done without "another movie built on the pseudo-psychological cliché that adults need to reconnect with their childhoods in order to be better adults," especially one led by the Hundred Acre Wood's "least memorable character." "It feels as if reality has invaded the Hundred Acre Wood and sullied it," he writes at RogerEbert.com, giving the film two stars.


A 6-year-old boy with autism is back with his family in Westchester County after he was found driving a motorized toy car on the Bronx River Parkway over the weekend.Officers found the boy on the mini ATV just after 7 p.m. Sunday in Mount Vernon."We just blocked it in, was like a box and he was right in the middle," said Ana Rubio, a Good Samaritan.Ana Rubio still gets emotional as she speaks about the little boy she held in her arms, along the Bronx River Parkway Sunday night."He was like, 'I need to go home, mom, mom,' all he kept saying was 'mom,'" Rubio said.Rubio didn't know the child but thank goodness she and several others including her husband, Joel, were there to help."The first guy who came in contact with the boy, he was almost shaking, he had goose bumps, saying, 'I almost hit the kid,'" said Joel Reyes, a Good Samaritan.The Good Samaritans are now being called angels.Investigators say several drivers slowed down to block the child from other traffic.They spotted the 6-year-old little boy, riding a toy ATV on the Bronx River Parkway, in the far right lane with cars whizzing by, going at least 45 mph."It seemed like the child wanted to continue driving, he was trying to merge on the middle lane of the highway," Rubio said.This twisted tale began roughly two miles from the parkway.Police say the little boy, who is autistic, was with his grandmother near a park on South 7th Avenue.He slipped away, got on his blue battery powered toy, and took off.Witnesses say the boy's mother showed up at the park and frantically start calling for her son."You saw kids going back and forth and I asked them 'Did you find him?' and they said 'No,'" said Genoveva Burgos, a witness.The boy was heading to the parkway, and it's a long journey for such a little guy.As his mother was reporting him missing, police began getting a ton of 911 calls about a boy on an ATV on the parkway.By then, Rubio and several others had safely gotten the 6-year-old to the side of the parkway."It seemed like he didn't know he was on a highway, he just wanted to go home," Rubio said.Then her heart skipped another beat."When he saw the police officer he was ready to run onto the highway but I grabbed him and hugged him and said, 'we're going to help you, the officer will take you home,'" Rubio said.The boy was taken to a hospital for observation and found to be OK. ||||| The Blue miniature battery-powered ATV that a 6-year-old autistic boy drove onto the northbound ramp of the Bronx River Parkway near Oak Street in Mount Vernon Sunday evening. The child was safely taken off the road after three motorists slowed their vehicles to surround and protect the boy from other vehicles that might not have seen him. (Photo: Westchester County police)

 An autistic 6-year-old boy drove a miniature battery-powered ATV onto the Bronx River Parkway and was pulled over by good Samaritans on Sunday night, authorities said.

 The trip started off in a city park around 7 p.m. when family members lost track of the boy, who rode off in the toy vehicle.

 "They realized pretty quickly he was gone but couldn't lay eyes on him," Kieran O'Leary, spokesman for the Westchester County police, said of the Mount Vernon family.

 Relatives reported the boy missing to Mount Vernon police.

 At about 7:40 p.m., Westchester County police started receiving 911 calls about the unlicensed driver traveling in his vehicle — made popular by the toy brand Power Wheels — on the parkway.

 He had driven to Oak Street, from a park about a mile away on South Seventh Avenue, and taken the ramp onto the northbound parkway, police said.

 The young driver didn't make it very far.

 Good Samaritan: 'You could barely see him driving by'

 Three motorists slowed their vehicles to surround the boy and protect him from other vehicles that might not see him, O'Leary said. Someone was able to get out of their vehicle, and grab the boy and his ride off the parkway.

 "These good Samaritans got him to the safety of the side of the road," the police spokesman said. Police officers arrived shortly after.

 The child was taken to Montefiore Mount Vernon Hospital for observation and found to be OK. He was reunited with his family.

 The Blue miniature battery-powered ATV that a 6-year-old autistic boy drove onto the northbound ramp of the Bronx River Parkway near Oak Street in Mount Vernon Sunday evening. The child was safely taken off the road after three motorists slowed their vehicles to surround and protect the boy from other vehicles that might not have seen him. (Photo: Westchester County Police)

 The incident is under investigation.

 Twitter: @gshilly

 Read or Share this story: http://lohud.us/1s3texI |||||

Write a summary.

– Drivers on the Bronx River Parkway were a little surprised to see a 6-year-old driving his miniature ATV beside them last night. The boy's mom was even more surprised to discover him missing. It started on a family trip to a park in Mount Vernon, New York, where the autistic boy rode off unnoticed at around 7pm, the Journal News reports. "They realized pretty quickly he was gone but couldn't lay eyes on him," a police spokesman said. Bystanders say the mother was frantically calling for her boy as kids ran back and forth looking for him, 7Online reports. Soon he had zoomed onto the northbound parkway and was even trying to merge into the middle lane, police and witnesses say. So drivers boxed him in and grabbed him just as police arrived. "He was like, 'I need to go home, mom, mom,' all he kept saying was 'mom,'" said Ana Rubio, one of the drivers. Another was said to be shaking with goosebumps, telling people, "I almost hit a kid." As for the boy, he seemingly "didn't know he was on a highway, he just wanted to go home," said Rubio. He was taken to a hospital first and "found to be OK," reports 7Online, but police are still investigating. (Read about an autistic boy allegedly kept in a cage.)


Article:

These crawls are part of an effort to archive pages as they are created and archive the pages that they refer to. That way, as the pages that are referenced are changed or taken from the web, a link to the version that was live when the page was written will be preserved.Then the Internet Archive hopes that references to these archived pages will be put in place of a link that would be otherwise be broken, or a companion link to allow people to see what was originally intended by a page's authors.The goal is to fix all broken links on the web . Crawls of supported "No More 404" sites. ||||| "So how do you spend your time now that the tour is over?"

 384K 13K ||||| Dec 07, 2018

 Dec 07, 2018

 The Recording Academy announced the nominations for the 2019 Grammy Awards, and reputation clinched a nomination for Best Pop Vocal Album . Watch the awards on February 10, 2019 on CBS. ||||| Focused crawls are collections of frequently-updated webcrawl data from narrow (as opposed to broad or wide) web crawls, often focused on a single domain or subdomain. ||||| (CNN) It seems Taylor Swift may be about to reveal something big and "Swifties" -- as her fans are affectionately called -- suspect it's a new album.

 The pop star has wiped out her internet presence -- her Instagram, Twitter, Tumblr, YouTube and website have gone black.

 The purge arrives on the three-year anniversary of the premiere of "Shake It Off," which served as the chart-topping lead single to Swift's last album, "1989."

 Coincidence? Possibly, or perhaps the musician is the latest victim of hacking. A rep for Swift did not immediately respond to CNN's request for comment.

 The dramatic move sent fans into a frenzy on social media, using the trending topic "#TS6IsComing" to announce their anticipation for Swift's sixth studio album.

 Swifties: *Had 3 LONG years of preparing and waiting*

 Taylor: *does something for just an hour*#TS6isComing

 Swifties: pic.twitter.com/RO6rmozFCX — #TS6isComing (@TheMomentIKnew) August 18, 2017

 miss swift is coming to end careers left right and centre #TS6ISCOMING pic.twitter.com/ir9eAmlxbX — jasmine (@kiingbiebah) August 18, 2017

 HIDE YOUR FAVES. HIDE THE AWARDS. HIDE THE CHARTS.#TS6IsComing — TS6 IS COMING (@slaylorstan) August 18, 2017

 #TS6IsComing I CANT BREATHE GOD HELP ME HELP US ITS HAPPENING FINALLY HAPPENING OMG pic.twitter.com/yHzvrPgHeo — Sara 🌹 (@SaraMaliha27) August 18, 2017

 NO IM NOT WHAT IS HAPPENING #TS6IsComing pic.twitter.com/uOmlYkByjv — Taqfia Muskaan (@taqfia111) August 18, 2017

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What is a summary?

– Three years after dropping her Grammy-winning album 1989, speculation over when fans will get a new record from Taylor Swift has reached a fever pitch. According to Pitchfork, the pop star mysteriously blacked out her online presence—all photos and posts on Swift’s Instagram, Twitter, and Facebook accounts have been removed, leaving her profiles completely blank. Meanwhile, visitors to the musician’s official site will find a blank, black screen. Per CNN, the “purge” arrived three years to the date of the release of her chart-topping hit, Shake It Off. The move also comes ahead of the MTV Video Music Awards (airing August 27), where Swift is rumored to make an appearance and squash her beef with host Katy Perry. (Swift recently made headlines after winning a groping case against a former DJ.)