Portfolio Minister Time frame Notes President Kwame Nkrumah[1] 1 July 1960 – 24 February 1966 Minister for Foreign Affairs[2] Imoru Egala 1960 – 1961 Ebenezer Ako-Adjei[1] 1961 – 1962 Kwame Nkrumah 1962 – 1963 Kojo Botsio[3] 1963 – 1965 Alex Quaison-Sackey[4] 1965 – 1966 Minister for Defence Charles de Graft Dickson[5][6] 1960 – 1961 Kofi Baako[1][7][6] September 1961 – 24 February 1966 Minister for Interior[2] Ashford Emmanuel Inkumsah 1960 – 1961 Kwaku Boateng[1][8] (Interior and Local Government) 1961 – 1964[9] Lawrence Rosario Abavana 1964 – 1965 Ashford Emmanuel Inkumsah 1 February 1965 – 1965 Lawrence Rosario Abavana 1965 – 1966 Minister for Finance Komla Agbeli Gbedemah[10] 1954 – May 1961 Ferdinand Koblavi Dra Goka[8][1] (Minister for Finance and Trade) 8 May 1961[11] – February 1964 Kwame Nkrumah February 1964 – ?