ALC-0315

ALC-0315 ([(4-hydroxybutyl)azanediyl]di(hexane-6,1-diyl) bis(2-hexyldecanoate)) is a component of the lipid mixture used in the SARS-CoV-2 vaccine, BNT162b2, from BioNTech and Pfizer to form lipid nanoparticles.
ALC-0315 is a physiological pH cationic synthetic lipid that can be used together with other lipids to form lipid nanoparticles (LNPs).
These nanoparticles promote the uptake of therapeutically effective nucleic acids such as oligonucleotides or messenger RNA both "in vitro" and "in vivo". 