MN1 (gene)

MN1 is a gene found on human chromosome 22, with gene map locus 22q12.3-qter. Its official full name is meningioma (disrupted in balanced translocation) 1 because it is disrupted by a balanced translocation (4;22) in a meningioma.
Function.
MN1 is a transcription coregulator that enhances or represses RAR/RXR-mediated gene transcription through interaction with RAC3 and p300. MN1 also acts as a coactivator of the vitamin D receptor.
Clinical significance.
Its inactivation may be part of the cause of certain meningiomas. A potential link to leukemia including acute myeloid leukemia has also been described.
Mutations in this gene have been associated with an atypical form of rhombencephalosynapsis.