CD226

CD226 (Cluster of Differentiation 226), PTA1 (outdated term, 'platelet and T cell activation antigen 1') or DNAM-1 (DNAX Accessory Molecule-1) is a protein that in humans is encoded by the "CD226" gene which is located on chromosome 18q22.3.
Structure and function.
CD226 is a ~65 kDa glycoprotein expressed on the surface of natural killer cells, platelets, monocytes and a subset of T cells. It is a member of the immunoglobulin superfamily containing 2 Ig-like domains of the V-set.
CD226 mediates cellular adhesion to other cells bearing its ligands, CD112 and CD155, and cross-linking CD226 with antibodies causes cellular activation.