Proligestone

Proligestone, sold under the brand names Covinan and Delvosteron, is a progestin medication which is used in veterinary medicine.
Uses.
Veterinary.
Proligestone is used to control estrus in dogs and cats and has also been used to treat hypersexuality in dogs and cats.
Pharmacology.
Pharmacodynamics.
Proligestone is a progestogen, or an agonist of the progesterone receptor (PR).
Chemistry.
Proligestone, also known as 14α,17α-propylidenedioxyprogesterone or as 14α,17α-dihydroxyprogesterone cyclic acetal with propionaldehyde, as well as 14α,17α-propylidenedioxypregn-4-ene-3,20-dione, is a synthetic pregnane steroid and a derivative of progesterone and 17α-hydroxyprogesterone. It is a C14α,17α cyclic ketal of 14α,17α-dihydroxyprogesterone.
History.
Proligestone was described as early as 1968 and was introduced for veterinary use in 1975.
Society and culture.
Generic names.
"Proligestone" is the generic name of the drug and its and .
Brand names.
Proligestone is marketed under the brand names Covinan and Delvosteron.
Availability.
Proligestone is or has been available for veterinary use in Argentina, Australia, Austria, Belgium, Czechoslovakia, France, Germany, Ireland, Italy, the Netherlands, New Zealand, Poland, South Africa, Switzerland, and the United Kingdom.