Posaconazole

Posaconazole, sold under the brand names Noxafil and Posanol is a triazole antifungal medication.
It was approved for medical use in the United States in September 2006, and is available as a generic medication.
Medical uses.
Posaconazole is used to treat invasive "Aspergillus" and "Candida" and fungal infections caused by "Scedosporium" and "Fusarium" species, which may occur in immunocompromised patients. It is also used for the treatment of oropharyngeal candidiasis (OPC), including OPC refractory to itraconazole and/or fluconazole therapy.
It is also used to treat invasive infections by "Candida", "Mucor", and "Aspergillus" species in severely immunocompromised patients.
Clinical evidence for its utility in treatment of invasive disease caused by "Fusarium" species (fusariosis) is limited.
It appears to be helpful in a mouse model of naegleriasis.
Pharmacology.
Pharmacodynamics.
Posaconazole works by disrupting the close packing of acyl chains of phospholipids, impairing the functions of certain membrane-bound enzyme systems such as ATPase and enzymes of the electron transport system, thus inhibiting growth of the fungi. It does this by blocking the synthesis of ergosterol by inhibiting of the enzyme lanosterol 14α-demethylase and accumulation of methylated sterol precursors. Posaconazole is significantly more potent at inhibiting 14-alpha demethylase than itraconazole.
Microbiology.
Posaconazole is active against the following microorganisms:
Pharmacokinetics.
Posaconazole is absorbed within three to five hours. It is predominately eliminated through the liver, and has a half-life of about 35 hours. Oral administration of posaconazole taken with a high-fat meal exceeds 90% bioavailability and increases the concentration by four times compared to fasting state.