Guineesine

Guineesine (or guineensine) is an alkaloid isolated from long pepper ("Piper longum") and black pepper ("Piper nigrum").
Research.
Guineensine inhibits the cellular reuptake of anandamide and 2-arachidonoylglycerol in a mouse model (EC50 = 290 nM). This causes an increase in the activity of the two neurotransmitters which are classified as endogenous cannabinoids.
Guineesine can dose-dependently produce cannabimimetic effects in a mouse model which are indicated by potent catatonic, analgesic, hypo-locomotive and hypo-thermic effects. In addition, the analgesic and catatonic effects were reversed by the cannabinoid receptor type 1 (CB1) inverse agonist rimonabant.
Guineesine is also a monoamine oxidase inhibitor (MAOI) "in vitro" (IC50 = 139.2 μM).