Conessine

Conessine is a steroid alkaloid found in a number of plant species from the family Apocynaceae, including "Holarrhena floribunda", "Holarrhena antidysenterica" and "Funtumia elastica". It acts as a histamine antagonist, selective for the H3 subtype (with an affinity of pKi = 8.27; Ki = ~5 nM). It was also found to have long CNS clearance times, high blood-brain barrier penetration and high affinity for the adrenergic receptors.