HCN1

Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 1 is a protein that in humans is encoded by the "HCN1" gene.
Function.
Hyperpolarization-activated cation channels of the HCN gene family, such as HCN1, contribute to spontaneous rhythmic activity in both heart and brain.
Tissue distribution.
HCN1 channel expression is found in the sinoatrial node, the neocortex, hippocampus, cerebellar cortex, dorsal root ganglion, trigeminal ganglion and brainstem.
Interactions.
HCN1 has been shown to interact with HCN2.
Epilepsy.
De novo mutations in HCN1 cause epilepsy.