Rutecarpine

Rutecarpine or rutaecarpine is a COX-2 inhibitor isolated from "Tetradium ruticarpum". It is claimed as one of the non-basic alkaloids.
In contrast to synthetic COX-2 inhibitors like Etoricoxib and Celecoxib Rutecarpine does not show their negative effects on the cardiovascular system; in fact it even does compensate for the adverse effects usually caused by COX-2 inhibition.