EPS15

Epidermal growth factor receptor substrate 15 is a protein that in humans is encoded by the "EPS15" gene.
Function.
This gene encodes a protein that is part of the EGFR pathway. The protein is present at clathrin-coated pits and is involved in receptor-mediated endocytosis of EGF. Notably, this gene is rearranged with the HRX/ALL/MLL gene in acute myelogeneous leukemias. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.
Model organisms.
Model organisms have been used in the study of EPS15 function. A conditional knockout mouse line, called "Eps15tm1a(KOMP)Wtsi" was generated as part of the International Knockout Mouse Consortium program—a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists—at the Wellcome Trust Sanger Institute.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on mutant mice and one significant abnormality was observed: homozygous mutant animals had a decreased mean corpuscular hemoglobin concentration.
Interactions.
EPS15 has been shown to interact with: