Archaeal initiation factors

Archaeal initiation factors are proteins that are used during the translation step of protein synthesis in archaea. The principal functions these proteins perform include ribosome RNA/mRNA recognition, delivery of the initiator Met-tRNAiMet, methionine bound tRNAi, to the 40s ribosome, and proofreading of the initiation complex.
Conservation of archaeal initiation factors.
Of the three domains of life, archaea, eukaryotes, and bacteria, the number of archaeal TIFs is somewhere between eukaryotes and bacteria; eukaryotes have the largest number of TIFs, and bacteria, having streamlined the process, have only three TIFs. Not only are archaeal TIF numbers between that of bacteria and eukaryote numbers, but archaeal initiation factors are seen to have both traits of eukaryotic and prokaryotic initiation factors. Two core TIFs, IF1/IF1A and IF2/IF5B are conserved across the three domains of life. There is also a semi-universal TIF found in all archaea and eukaryote called SUI1, but only in certain bacterial species (YciH). In archaea and eukaryotes, these TIFs help correct the identification of the initiation codon, while its function is unknown in bacteria. Just between eukaryote and archaea, a/eIF2 (trimer) and aIF6 in archaea are conserved in eukaryotes as eIF2(trimer) and eIF6 TIFs.