Neuroprotectin

Neuroprotectin D1 (NPD1) (10"R",17"S"-dihydroxy-4"Z",7"Z",11"E",13"E",15"Z",19"Z"-docosahexaenoic acid) also known as Protectin D1 (PD1) is a docosanoid derived from the polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA), which is a component of fish oil and the most important omega-3 PUFA. Like other members of the specialized proresolving mediators class of PUFA metabolites, NPD1 exerts potent anti-inflammatory and anti-apoptotic/neuroprotective bioactivity. Other neuroprotectins with similar activity include: PDX (10"R",17"S"-dihydroxy-4"Z",7"Z",11"E",13"Z",15"E",19"Z"-docosahexaenoic acid); 20-hydroxy-PD1 (10"R",17"S",20-trihydroxy-4"Z",7"Z",11"E",13"E",15"Z",19"Z"-docosahexaenoic acid); and 10-epi-PD1 (10"R",17"S"-Dihydroxy-4"Z",7"Z",11"E",13"E",15"Z",19"Z"-docosahexaenoic acid). The activity of neuroprotectin-like metabolite, 17-epi-PD1 (10"R",17"R"-dihydroxy-4"Z",7"Z",11"E",13"E",15"Z",19"Z"-docosahexaenoic acid), has not yet been reported.
Neuroprotectins A and B, which are bicyclohexapeptides, are to be distinguished structurally and mechanistically from the neuroprotectin D's.