BH11960

 
"Bartonella henselae" hypothetical protein 11960 (BH11960) is encoded by the "BH11960" gene. This hypothetical protein is conserved in all "Bartonella" species whose genomes have been sequenced to date, and are highlighted in the picture below.
Properties.
“Hypothetical protein BH11960 ("Bartonella henselaei" str. Houston-1”. .
Function.
The function of the BH11960 protein is not known, but its function is thought to be involved in signal transduction that regulates aerotolerance in conjunction with the other genes within its cluster. Evidence for such function is:
Protein sequence.
The importance of this protein lies in the beginning of the sequence, and is represented in the conceptual translation below. This region contains the aerotolerance motif, the transmembrane hydrophobic segment highlighted in yellow, and a high-conservation region represented in all studied orthologs. Furthermore, a signal peptide protein is present in this region that allows transport of a protein.
Based on sequence analysis performed by PSortB program, this protein is located in the cytoplasmic membrane of this Gram-negative bacterium and contains a double transmembrane domain.
Gene neighborhood.
The four-gene cluster of "BH11940, BH11950, BH11960", and "BH11970" all produce proteins of unknown function transcribed on the sense strand and encoded by the same promoter. The promoter is ubiquitously conserved in the other" Bartonella" species and contains a TATA box. BH11960 is the largest of the four proteins.
"Bartonella henselae": BH11960. KEGG Database. .