Carnitine palmitoyltransferase II

Carnitine O-palmitoyltransferase 2, mitochondrial is an enzyme that in humans is encoded by the "CPT2" gene.
Function.
Carnitine palmitoyltransferase II precursor (CPT2) is a mitochondrial membrane protein which is transported to the mitochondrial inner membrane. CPT2 together with carnitine palmitoyltransferase I oxidizes long-chain fatty acids in the mitochondria. Defects in this gene are associated with mitochondrial long-chain fatty-acid (LCFA) oxidation disorders and carnitine palmitoyltransferase II deficiency.
Model organisms.
Model organisms have been used in the study of CPT2 function. A conditional knockout mouse line called "Cpt2tm1b(KOMP)Wtsi" was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping 