Ichthyotoxin

Ichthyotoxins are compounds which are either toxic to fish or are toxins produced by fish. The toxins can be found in gar eggs and the eggs of several other species' roe. It can also be found in some species of algae such as prymnesium parvum. They include euglenophycin and prymnesins, made by algae and can cause large-scale fish deaths, and ostracitoxin made by boxfish. Many toxin producing algal species can be found both in marine and fresh water environments when the algae is in bloom. The toxin is protein based and is poisonous to humans, small mammals, and some fish. An ichthyotoxic poisoning (in humans) can cause symptoms ranging in severity dependent on how much toxin was consumed. The symptoms of an ichthyotoxin poisoning can include headache, vomiting, diarrhea, dizziness, drop in blood pressure, and many others.
Anti-cancer Research.
It was discovered that euglonophycin, a euglenoid ichthyotoxin derived from "Euglena sanguinea", displays anticancer activity. By sharing a similar chemical structure to solenopsin, an angiogenic inhibitor and alkaloid toxin derived from fire ant venom, euglonophycin has been studied for potential application in natural products and drug development for cancer therapy. Based on experimental studies, anti-cancer activity by euglonophycin was demonstrated in leukemia, neuroblastoma, and colorectal cancer cell lines. Specifically, in colorectal cancer cells, euglenophycin exposure exhibited cytotoxic, anti-proliferative, anti-migratory, and anti-inflammatory activity.  It was determined that autophagic regulation and G1 cell cycle arrest contributes to euglenophycin’s ability to inhibit colorectal cancer cell proliferation, prevent metastasis, and suppress tumor inflammation.  