Redondoviridae

Redondoviruses (members of the Redondoviridae) are a family of human-associated DNA viruses. Their name derives from the inferred circular structure of the viral genome (“” means round in Spanish). Redondoviruses have been identified in DNA sequence based surveys of samples from humans, primarily samples from the oral cavity and upper airway.
Virology.
Taxonomy.
Redondoviruses are assigned to a new family by the International Committee on Taxonomy of Viruses (ICTV), the "Redondoviridae".
Classification.
The family "Redondoviridae" is divided into two species, "Brisavirus" and "Vientovirus". The names derive from the words for breeze and wind in Spanish (“” and “"viento"”), denoting the association with the human airway. Multiple strains have been proposed on the basis of viral genome structure.
The redondoviruses are members of the Circular Rep-Containing Single Stranded (CRESS) DNA Virus group.
Genome.
The redondovirus genome is circular, and by analogy to other CRESS viruses likely single stranded. Genomes range in size from about 3.0 to 3.1 kilobases. The genome encodes three inferred proteins:
Epidemiology.
Distribution.
Redondovirus genomes have been reported primarily from human samples surveyed using metagenomic DNA sequencing. They have been found primarily in oral and airway specimens.
Disease associations.
It is unknown whether redondoviruses cause human disease. Some CRESS viruses are known pathogens, such as porcine circovirus type 2
Redondoviruses have been reported associated with periodontitis. In one study, the levels fell with successful treatment. Abundance of redondovirus genomes has also been found to be high in some intensive care unit patients. At present the basis of these disease associations is unclear.