LHX3

LIM/homeobox protein Lhx3 is a protein that in humans is encoded by the "LHX3" gene.
Function.
"LHX3" encodes a protein of a large protein family, members of which carry the LIM domain, a unique cysteine-rich zinc-binding domain. The encoded protein is a transcription factor that is required for pituitary development and motor neuron specification. Two transcript variants encoding distinct isoforms have been identified for this gene.
Clinical significance.
Mutations in this gene have been associated with a syndrome of combined pituitary hormone deficiency and rigid cervical spine.
Interactions.
LHX3 has been shown to interact with Ldb1.