Interferon gamma receptor 2

Interferon gamma receptor 2 also known as IFN-γR2 is a protein which in humans is encoded by the "IFNGR2" gene.
Function.
This gene ("IFNGR2") encodes the non-ligand-binding beta chain of the gamma interferon receptor. Human interferon-gamma receptor is a multimer of two IFN-γR1 chains (encoded by IFNGR1) and two IFN-γR2 chains.
Clinical significance.
Defects in "IFNGR2" are a cause of autosomal recessive mendelian susceptibility to mycobacterial disease (MSMD), also known as familial disseminated atypical mycobacterial infection.
All known mutations in "IFNGR2" are collected in the "IFNGR2" mutation database.