PSCA (gene)

Prostate stem cell antigen is a protein that in humans is encoded by the "PSCA" gene.
This gene encodes a glycosylphosphatidylinositol-anchored cell membrane glycoprotein. In addition to being highly expressed in the prostate it is also expressed in the bladder, placenta, colon, kidney, and stomach. This gene has a nonsynonymous nucleotide polymorphism at its start codon.
Clinical significance.
This gene is up-regulated in a large proportion of prostate cancers and is also detected in cancers of the bladder and pancreas.