Complement component 5

Complement component 5 is a protein that in humans is encoded by the "C5" gene.
Complement component 5 is involved in the complement system. It is cleaved into C5a and C5b:
Deficiency is thought to cause Leiner's disease.
Function.
Complement component 5 is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is composed of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a C5-convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components.
Clinical significance.
Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis.
Therapeutic applications.
The drug eculizumab (trade name Soliris) prevents cleavage of C5 into C5a and C5b.