FMNL2

Formin-like protein 2 is a protein that in humans is encoded by the "FMNL2" gene.
Expression.
Alternatively spliced transcript variants of the FMNL2 gene encoding different isoforms have been described. The full length FMNL2 (FRL3) protein (1092 amino acids-NCBI Reference Sequence: NP_443137.2) is regulated through autoinhibition, and may become activated through Rho proteins. The FMNL2 gene is expressed in multiple human tissues.
Function.
Formin-like protein 2 is a formin-related protein. Formin-related proteins have been implicated in morphogenesis, cytokinesis, and cell polarity.
Clinical significance.
FMNL2 expression is considerably higher in colorectal cancer tumors compared to normal tissue.