Centromere protein E

Centromere-associated protein E is a protein that in humans is encoded by the "CENPE" gene.
Centromere-associated protein E is a kinesin-like motor protein that accumulates in the G2 phase of the cell cycle. Unlike other centromere-associated proteins, it is not present during interphase and first appears at the centromere region of chromosomes during prometaphase. CENPE is proposed to be one of the motors responsible for mammalian chromosome movement and/or spindle elongation.
Clinical significance.
Mutations in "CENPE" result in autosomal recessive primary microcephaly type 13, which includes skeletal abnormalities and immunodeficiency.