KDM6B

Lysine demethylase 6B is a protein that in humans is encoded by the KDM6B gene.
Regulation during differentation.
KDM6B was found to be expressional increased during cardiac and endothelial differentation of murine embryonic stem cells.
Small molecule inhibition.
A small molecule inhibitor (GSK-J1) has been developed to inhibit the jumonji domain of KDM6 histone demethylase family to modulate proinflammatory response in macrophages.
Diagnosis.
Standard laboratory exome sequencing can be used to identify the KDM6B gene variant.
Prognosis.
A 2019 study on symptoms from KDM6B variations reported:
Epidemiology.
For patients reporting intellectual disability and/or developmental delay, approximately 0.12% have de novo alterations in the KDM6B gene
See also.
Overlapping phenotypic features for patients between KDM6A associated with Kabuki syndrome and KDM6B variations include prominent ears, abnormal dentition, congenital heart disease, feeding difficulties, cryptorchidism, joint hyper-mobility, developmental delay, hypotonia, and behavioral difficulties.