Daf-5

Daf-5 is an ortholog of the mammalian protein Sno/Ski，which present in the nematode worm "Caenorhabditis elegans" on the downstream of TGFβ signaling pathway. Without daf-7 signal, daf-5 combined with daf-3, co-SMAD for "C. elegans", to form a heterodimer and started dauer development.