CCL4

Chemokine (C-C motif) ligands 4, also known as CCL4, is a protein which in humans is encoded by the "CCL4" gene.
Function.
CCL4, also known as Macrophage inflammatory protein-1β (MIP-1β) is a CC chemokine with specificity for CCR5 receptors. It is a chemoattractant for natural killer cells, monocytes and a variety of other immune cells.
CCL4 is a major HIV-suppressive factor produced by CD8+ T cells.
Perforin-low memory CD8+ T cells that normally synthesize MIP-1-beta.
CCL4 is produced by: neutrophils, monocytes, B cells, T cells, fibroblasts, endothelial cells, and epithelial cells.
Concentration of this chemokine has been shown to be inversely related with MicroRNA-125b. Concentration of CCL4 within the body increases with age, which may cause chronic inflammation and liver damage.
Interactions.
CCL4 has been shown to interact with CCL3.
CCL4 binds to G protein-Coupled Receptors CCR5 and CCR8.