DEK (gene)

The human DEK gene encodes the DEK protein.
Function.
This gene encodes a protein with one SAP domain. The protein binds to cruciform and superhelical DNA and induces positive supercoils into closed circular DNA. It is also involved in splice site selection during mRNA processing. Chromosomal aberrations involving this region increased expression of this gene and the presence of antibodies against this protein are all associated with various diseases.
Interactions.
"DEK" interacts with TFAP2A.