KIAA1797

KIAA1797 is a protein that in humans is encoded by the "KIAA1797" gene.
A specific single-nucleotide polymorphism rs7875153 in "KIAA1797 "is associated with heart rate.
Gene.
"KIAA1797" is a protein-coding gene in "Homo sapiens". Alternate names for the gene are FLJ20375, OTTHUMP00000069845, and hypothetical protein LOC54914. Located on chromosome 9 at area q21.3, the entire gene including introns and exons is 375,010 base pairs on the plus strand. There are 19 alternative splice variants. Longest variant yields an mRNA of 6117 base pairs.
Expression.
"KIAA1797" was determined to express ubiquitously at varying levels throughout the human body. Based on the EST profile of Unigene, "KIAA1797" expression has been observed in tissues ranging from reproductive to secretory.
mRNA.
Predicted secondary mRNA structures in the 5'UTR and the 3'UTR are ugagaugaacucgguaucuca and uccuaagagaggag, respectively. Other possible secondary structures are shown in the table below.
Protein sequence.
The main isoform of the human protein is 1801 amino acids long, a total of 200,072 Da.
Two distinct domains of unknown function (DUF) are found in the sequence. DUF3730 (465-682aa) appears two times in the sequence; this domain family is found in eukaryotes and is typically between 220 and 262 amino acids in length. DUF3028(1213-1801aa). No additional information was available regarding this DUF.
Homology.
"KIAA1797" is well conserved in mammals, but it is also found in nonmammalians with lower sequence identities.
Gene neighborhood.
"KIAA1797" is downstream of "MLLT3" and upstream of "PTPLAD2". " MLLT3" is involved with myeloid/lymphoid or mixed-lineage leukemia. "PTPLAD2" is a protein tyrosine phosphatase.
Function.
The exact function of "KIAA1797" is not yet understood by the scientific community. It is, however, found to be a transmembrane protein.