ASTE1

Asteroid homolog 1 (Drosophila) is a protein that in humans is encoded by the "ASTE1" gene. The gene is also known as "HT001".
Model organisms.
Model organisms have been used in the study of ASTE1 function. A conditional knockout mouse line, called "Aste1tm1a(KOMP)Wtsi" was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists.
Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty four tests were carried out on homozygous mutant mice and one significant abnormality was observed: females had an increased susceptibility to bacterial infection.