CBX7 (gene)

Chromobox homolog 7 is a protein that in humans is encoded by the "CBX7" gene. The loss of "CBX7" gene expression has been shown to correlate with a malignant form of thyroid cancer.
Model organisms.
Model organisms have been used in the study of CBX7 function. A conditional knockout mouse line, called "Cbx7tm1a(KOMP)Wtsi" was generated as part of the International Knockout Mouse Consortium program — a high-throughput mutagenesis project to generate and distribute animal models of disease to interested scientists — at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty six tests were carried out and three significant phenotypes were reported. Homozygous mutant female adults showed a decreased response to stress-induced hyperthermia and had an increased red blood cell count. Animals of both sex had an integument phenotype when tail epidermis was examined.