Cell adhesion molecule 1

Cell adhesion molecule 1 is a protein that, in humans, is encoded by the "CADM1" gene.
Model organisms.
Model organisms have been used in the study of CADM1 function. A conditional knockout mouse line, called "Cadm1tm1.2Brd" was generated. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Twenty six tests were carried out on homozygous mutant mice and one significant abnormality was observed: males were infertile. Further analysis showed spermatogenesis had arrested in these mice.
Interactions.
Cell adhesion molecule 1 has been shown to interact with EPB41L3.
Association studies.
Genome-wide association studies identified an association between body mass index and two loci near the "CADM1" and "CADM2" gene. Experimental results of another study showed that obese mice had an over expression of both "CADM1" and "CADM2" genes, and that loss of "CADM1" protected mice from obesity, promoting a negative energy balance and weight loss. 
Furthermore, a 2019 GWAS study revealed an association between Anorexia nervosa and "CADM1".
In the brain, this genes mediate synaptic assembly, and mutations in "CADM1" are also associated with Autistic spectrum disorder. 