ACER1

Alkaline ceramidase 1 also known as ACER1 is a ceramidase enzyme which in humans is encoded by the "ACER1" gene.
Function.
ACER1 mediates cellular differentiation by controlling the generation of sphingosine (SPH) and sphingosine-1-phosphate (S1P).
Model organisms.
Model organisms have been used in the study of ACER1 function. A conditional knockout mouse line called "Acer1tm1a(EUCOMM)Wtsi" was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping - in-depth bone and cartilage phenotyping