ATG16L1

Autophagy related 16 like 1 is a protein that in humans is encoded by the "ATG16L1" gene.
Function.
Autophagy is the major intracellular degradation system delivering cytoplasmic components to lysosomes, and it accounts for degradation of most long-lived proteins and some organelles. Cytoplasmic constituents, including organelles, are sequestered into double-membraned autophagosomes, which subsequently fuse with lysosomes. ATG16L1 is a component of a large protein complex essential for autophagy.
Clinical significance.
Mutations in the ATG16L1 gene may be linked to Crohn's disease.