LEKTI-2

Lympho-epithelial Kazal-type related inhibitor 2 (LEKTI-2) is a protein encoded by the "SPINK9" gene in humans. LEKTI-2 is an inhibitor of KLK5, a serine protease expressed in the epidermis and responsible for coordinating skin homeostasis and desquamation. "SPINK9" is a member of a gene family cluster located on chromosome 5q33.1, which includes "SPINK5" and "SPINK6".