KIF5A

Kinesin heavy chain isoform 5A is a protein that in humans is encoded by the "KIF5A" gene.
This gene encodes a member of the kinesin family of proteins. Members of this family are part of a multisubunit complex that functions as a microtubule motor in intracellular organelle transport. Mutations in this gene cause autosomal dominant spastic paraplegia 10.
Interactions.
KIF5A has been shown to interact with KLC1.
Clinical significance.
Mutations in "KIF5A" were reported to cause hereditary spastic paraplegia type 10 (SPG1) by Douglas Marchuk in 2002. In 2018, mutations in "KIF5A" were also found to cause amyotrophic lateral sclerosis by Bryan Traynor and John Landers. KIF5A also plays a role in Alzheimer's disease by modulating the toxic effect of beta-amyloid on axonal transport of mitochondria. 