KMT5A

N-lysine methyltransferase KMT5A is an enzyme that in humans is encoded by the "KMT5A" gene. The enzyme is a histone methyltransferase, SET domain-containing and lysine-specific. The enzyme transfers one methyl group to histone H4 lysine residue at position 20. "S"-Adenosyl methionine (SAM) is both the cofactor and the methyl group donor. The lysine residue is converted to "N"6-methyllysine residue.
This histone modification is often abbreviated H4K20me1: