SERINC3

Serine incorporator 3 is a protein that in humans is encoded by the "SERINC3" gene. It has been demonstrated that SERINC3 acts as a retrovirus restriction factor. 
Model organisms.
Model organisms have been used in the study of SERINC3 function. A conditional knockout mouse line called "Serinc3tm1a(KOMP)Wtsi" was generated at the Wellcome Trust Sanger Institute. Male and female animals underwent a standardized phenotypic screen to determine the effects of deletion. Additional screens performed: - In-depth immunological phenotyping 