(S,S)-Tetrahydrochrysene

("S","S")-Tetrahydrochrysene (("S","S")-THC) is a steroid-like nonsteroidal estrogen and agonist of both the estrogen receptors, ERα and ERβ. It is an enantiomer of ("R","R")-tetrahydrochrysene (("R","R")-THC), which, in contrast, is an ERβ silent antagonist and ERα agonist with 10-fold selectivity (i.e., affinity) for the ERβ over the ERα and with 20-fold greater affinity for the ERβ relative to that of ("S","S")-THC.