Pyrroline-5-carboxylate reductase

In enzymology, a pyrroline-5-carboxylate reductase () is an enzyme that catalyzes the chemical reaction
The 3 substrates of this enzyme are -proline, NAD+, and NADP+, whereas its 4 products are 1-pyrroline-5-carboxylate, NADH, NADPH, and H+.
This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is -proline:NAD(P)+ 5-oxidoreductase. Other names in common use include proline oxidase, -proline oxidase, 1-pyrroline-5-carboxylate reductase, NADPH-L-Delta1-pyrroline carboxylic acid reductase, and -proline-NAD(P)+ 5-oxidoreductase. This enzyme participates in arginine and proline metabolism.
Structural studies.
As of late 2007, 5 structures have been solved for this class of enzymes, with PDB accession codes , , , , and .