
Bacillus subtilis type I antitoxin SR6

SR6 is a 100 nucleotide long antisense RNA antitoxin that overlaps 2 toxins: 3' end of "yonT" and "yoyJ" at its 5'end. In type I toxin-antitoxin (TA) systems the antitoxin is a small RNA that neutralizes a toxin protein. Several type I TA systems have been described in "B. subtilis". "YonT"/SR6 system is located on the SPβ prophage of the "B. subtilis" chromosome and it was shown to be multi-stress responsive. SR6 acts by promoting "yonT" mRNA degradation. It may regulate the second toxin, "yoyJ" by a different mechanism.