Tripartite motif family

The tripartite motif family (TRIM) is a protein family.
Function.
Many TRIM proteins are induced by interferons, which are important component of resistance to pathogens and several TRIM proteins are known to be required for the restriction of infection by lentiviruses. TRIM proteins are involved in pathogen-recognition and by regulation of transcriptional pathways in host defence.
Structure.
The tripartite motif is always present at the N-terminus of the TRIM proteins. The TRIM motif includes the following three domains:
The C-terminus of TRIM proteins contain either:
Family members.
The TRIM family is split into two groups that differ in domain structure and genomic organization:
Members of the family include: