Pro-hevein

Pro-hevein (Alternative name: Major hevein, gene name: HEV1) is a wound-induced and a lectin-like protein from "Hevea brasiliensis" (rubber tree) where it is involved in the coagulation of latex.
The 187 amino-acid propeptide pro-hevein is cleaved in two fragments: a N-terminal 43 amino-acid Hevein bearing a chitin-binding type-1 domain (also known as CBM18 carbohydrate-binding module) that binds to chitin and a 138 amino-acid Win-like protein bearing a Barwin domain.
It has antifungal properties.
Role of hevein in latex allergy.
Hevein is the main IgE-binding epitope of the major latex allergen prohevein as are hevein-like protein domains in fruit class I chitinases. Therefore it is a possible cause for allergen cross-reactivity between latex and banana or other fruits like chestnuts or avocadoes. Hevein-like genes can be found in many plants including "Arabidopsis thaliana".
Hevein is called "Hev b 6" under the WHO allergen nomenclature. There are three entries under this classification, corresponding to the conformational epitopes "Hev b 6.01", "Hev b 6.03", and "Hev b 6.03". They correspond to the full Pro-Havein protein, the matur Hevein (N-terminal), and the C-terminal Barwin domain respectively.