Lactucopicrin

Lactucopicrin (Intybin) is a bitter substance that has a sedative and analgesic effect, acting on the central nervous system. It is a sesquiterpene lactone, and is a component of lactucarium, derived from the plant "Lactuca virosa" (wild lettuce), as well as being found in some related plants such as "Cichorium intybus". It is also found in dandelion coffee.
As well as their traditional use as sedatives and analgesics, these plants have also been used as antimalarials, and both lactucin and lactucopicrin have demonstrated antimalarial effects "in vitro". Lactucopicrin has also been shown to act as an acetylcholinesterase inhibitor.