Alpha,alpha-trehalose-phosphate synthase (UDP-forming)

In enzymology, an alpha,alpha-trehalose-phosphate synthase (UDP-forming) () is an enzyme that catalyzes the chemical reaction
Thus, the two substrates of this enzyme are UDP-glucose and D-glucose 6-phosphate, whereas its two products are UDP and alpha,alpha'-trehalose 6-phosphate.
This enzyme belongs to the family of glycosyltransferases, specifically the hexosyltransferases. The systematic name of this enzyme class is "UDP-glucose:D-glucose-6-phosphate 1-alpha-D-glucosyltransferase". Other names in common use include "UDP-glucose-glucose-phosphate glucosyltransferase", "trehalosephosphate-UDP glucosyltransferase", "UDP-glucose-glucose-phosphate glucosyltransferase", "alpha,alpha-trehalose phosphate synthase (UDP-forming)", "phosphotrehalose-uridine diphosphate transglucosylase", "trehalose 6-phosphate synthase", "trehalose 6-phosphate synthetase", "trehalose phosphate synthase", "trehalose phosphate synthetase", "trehalose phosphate-uridine diphosphate glucosyltransferase", "trehalose-P synthetase", "transglucosylase", and "uridine diphosphoglucose phosphate glucosyltransferase". This enzyme participates in starch and sucrose metabolism.
Structural studies.
As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes , , and .