TRIM33

Tripartite motif-containing 33 (TRIM33) also known as transcriptional intermediary factor 1 gamma (TIF1-γ), is a human gene.
The protein encoded by this gene is thought to be a transcriptional corepressor. However unlike the related TIF1-α and TIF1-β proteins, few transcription factors such as Smad4 that interact with TIF1-γ have been identified.
Structure.
The protein is a member of the tripartite motif family. This motif includes three zinc-binding domains:
and a coiled-coil region.
Three alternatively spliced transcript variants for this gene have been described, however, the full-length nature of one variant has not been determined.
Interactions.
TRIM33 has been shown to interact with TRIM24.
Role in cancer.
TRIM33 acts as a tumor suppressor gene preventing the development chronic myelomonocytic leukemia.
TRIM33 regulates also the TGF-β1 receptor and promotes physiological aging of hematopoietic stem cells.
TRIM33 acts as an oncogene by preventing apoptosis in B-cell leukemias.