Dihydroceramide desaturase

Dihydroceramide desaturase is the enzyme involved in the conversion of dihydroceramide into ceramide by inserting the 4,5-"trans"-double bond to the sphingolipid backbone of dihydroceramide. DDase require the and the NAD(P)H as cofactor.
The activity of DDase is influenced by several factors as 
N-[(1R,2S)-2-hydroxy-1-hydroxymethyl-2-(2-tridecyl-1-cyclopropenyl)ethyl]octanamide (GT11), is the inhibitor DDase activity.