DExD/H box proteins

DEAD box, DEAH, and the SKI families of proteins are all referred to as DExD/H box proteins. They are all quite distinct from one another and there is not one protein that belongs to more than one of these families. It is thought that each family may have a specific role in RNA metabolism, for example both DEAD box and DEAH box proteins NTPase activities become stimulated by RNA, but DEAD box proteins specifically hydrolyze ATP whereas DEAH can hydrolyze ATP and other NTPs.