ELQ-300

ELQ-300 is an experimental antimalarial medication. It is the first entry in a new class of antimalarials known as "4-quinolone-3-diarylethers".
ELQ-300 acts as an inhibitor of the mitochondrial cytochrome "bc"1 complex (complex III in the electron transport chain) - A mechanism shared with some of the most potent fungicides known, the strobilurins. In preclinical studies with mice, ELQ-300 was found to be highly active against "Plasmodium falciparum" and "Plasmodium vivax" at all life cycle stages that play a role in the transmission of malaria, and to have good oral bioavailability.