Diamphidia nigroornata

Diamphidia nigroornata or Bushman arrow-poison beetle, is an African leaf beetle species in the genus "Diamphidia".
The larvae and pupae of "Diamphidia" produce a toxin used by San people as an arrow poison.
The Finnish explorer Hendrik Jacob Wikar, who travelled in Southern Africa in 1773–1779, described the larvae as "poisonous worms". Hans Schinz was the first scientist to document the process by which the San people extract and use the poison.
The adults and larvae of "Diamphidia nigroornata" feed on "Commiphora angolensis".
Life cycle.
Adult females of "Diamphidia nigroornata" lay their eggs on the stems of "Commiphora" species and coat the eggs with their faeces which harden into a protective covering. As the larval instars develop, the pellets of their own faeces remain attached to their backs and posteriors. The final instar sheds this faecal coat when entering the soil to pupate. The "Diamphidia" larvae burrow down for a depth of up to 1 metre in the sand under the food plant, where they may lie dormant for several years before going through a very rapid pupal phase.
Toxin.
Diamphotoxin, the poisonous compound in "Diamphidia", is highly labile, and has a low molecular weight. It is bound to a protein that protects it from deactivation. It causes an increased permeability of cell membranes, which, while not affecting normal ionic flow between cells, allows easy access to "all" small ions, thereby fatally disrupting normal cellular ionic levels. Although it has no neurotoxic effect, it produces a lethal haemolytic effect, and may reduce haemoglobin levels by as much as 75%, leading to haemoglobinuria.
Parasite host.
"Diamphidia" is parasitised by a carabid "Lebistina" beetle, the larva of which attaches itself to a mature "Diamphidia" larva, clinging to it until the "Diamphidia" has formed its cocoon, enclosing both host and parasite, and then feeding on its host's soft tissue. The "Lebistina" larvae are more toxic than their hosts and are preferred by San hunters for arrow poison.