Aqua Tofana

Aqua Tofana (also known as Acqua Toffana, Acquetta Perugina, and Aqua Tufania and Manna di San Nicola) was a strong poison that was reputedly widely used in Naples, Perugia, and Rome, Italy. During the early 17th century Giulia Tofana, or Tofania, a woman from Palermo, made a good business for over twenty years selling her large production (she employed several helpers) of Aqua Tofana to would-be widows.
Original creation.
The first recorded mention of Aqua Tofana (literally meaning "Tofana water") is from 1632–33.
Perhaps an older recipe had been refined by Tofana and her daughter, Girolama Spera, around 1650 in Rome. The 'tradename' "Manna di San Nicola", i.e. "Manna of St. Nicholas of Bari" may have been a marketing device intended to divert the authorities, given that the poison was openly sold both as a cosmetic and a devotionary object in vials that included a picture of St. Nicholas. Some of her customers claimed to have used it for its advertised purposes and caused deaths only accidentally. Over 600 victims are alleged to have died from this poison, mostly abusive husbands, in a time where women did not have any rights or protection. Tofana was arrested and confessed to producing the poison, and she implicated several of her clients, claiming that they knew what they were buying. She was executed in July 1659. There was much disquiet throughout Italy and many of her clients fled, while others were strangled in prison, and indeed many were publicly executed. Between 1666 and 1676 the Marchioness de Brinvilliers poisoned her father and two brothers, amongst others, and she was executed on July 16, 1676.
Ingredients.
The ingredients of the mixture are basically known but not how they were blended. Aqua Tofana contained mostly arsenic and lead and possibly belladonna. It was a colorless, tasteless liquid and therefore easily mixed with water or wine to be served during meals.
Symptoms.
Poisoning by Aqua Tofana could go unnoticed as the substance is clear and has no taste. It is slow-acting, with symptoms resembling those of a progressive disease or other natural causes. The symptoms seen are similar to the effects of arsenic poisoning. Several symptoms were reported by those poisoned by Aqua Tofana. The first small dosage would produce cold-like symptoms. The victim was very ill by the third dose; symptoms included vomiting, dehydration, diarrhea, and a burning sensation in the digestive system. The antidote often given was vinegar and lemon juice. The fourth dose would kill the victim. As it was slow-acting, it allowed victims time to prepare for their death, including writing a will and repenting.
Legend about Mozart.
The legend that Mozart (1756—1791) was poisoned using Aqua Tofana is completely unsubstantiated, even though it was Mozart himself who started this rumor. Research by musicologists Oliver Hahn and Claudia Maurer Zenck on Mozart's manuscripts, however, revealed large amounts of arsenic in the manuscript of "Die Zauberflöte", the opera Mozart was working on towards the end of his life. Arsenic is a key ingredient of Aqua Tofana.