Nicotiana rustica

Nicotiana rustica, commonly known as Aztec tobacco or strong tobacco, is a rainforest plant in the family Solanaceae. It is a very potent variety of tobacco, containing up to nine times more nicotine than common species of "Nicotiana" such as "Nicotiana tabacum" (common tobacco). More specifically, "N. rustica" leaves have a nicotine content as high as 9%, whereas "N. tabacum" leaves contain about 1 to 3%. The high concentration of nicotine in its leaves makes it useful for producing pesticides, and it has a wide variety of uses specific to cultures around the world. However, "N. rustica" is no longer cultivated in its native North America, as "N. tabacum" has replaced it.
Uses.
South America.
"Nicotiana rustica" is called "mapacho" in South America. It is often used for entheogenic purposes by South American shamans, because of its high nicotine content and comparatively high levels of beta-carbolines, including the harmala alkaloids harmane and norharmane. There are many methods of administration in South American ethnobotanical preparations. In a preparation known as "singado" or "singa", "N. rustica" is allowed to soak or be infused in water, and the water is then insufflated into the stomach. The plant is also smoked in cigars, used in enemas, and made into a lickable product known as "ambil". Finally, "N. rustica" is a common ingredient in "rapé", a smokeless tobacco product usually used as a nasal snuff. "Rapé" is often a combination of "N. rustica" and a host of other herbs, depending on the intended use, including tonka beans, cinnamon, clove buds, alkaline ashes (creating "nu-nu"), Anadenanthera, Erythroxylum, Virola, and more.
Russia.
In Russia, "N. rustica" is called "makhorka" (маxорка). Historically, makhorka was smoked mainly by the lower classes. "N. rustica" is a hardy plant and can be grown in most of Russia (as opposed to "N. virginiana" which requires a warm climate), it was more readily and cheaply available, and did not depend on transport in a country with an underdeveloped road network and climatic portage problems. This remained the case until ordinary tobacco became widely available in the 20th Century. During Soviet times, rustic tobacco was an important industrial crop of agriculture. In those times, dozens of varieties were bred, some of them considered equal in quality to "N. virginiana". In modern times, makhorka is still sometimes smoked by peasants and farmers due to its high availability and being almost free for them.
Vietnam.
The plant is called "Thuốc lào" in Vietnam, and is most commonly smoked after a meal on a full stomach to "aid in digestion", or along with green tea or local beer (most commonly the cheap bia hơi). A "rít" of thuốc lào is followed by a flood of nicotine to the bloodstream inducing strong dizziness that lasts several seconds. Heavy cigarette smokers have had trouble with the intense volume of smoke and the high nicotine content; side effects include nausea and vomiting.
The main difference between smoking thuốc lào and the use of other tobaccos is in the method of consumption, in that thuốc lào is consumed with a water pipe. The smoker is presented with either a bamboo pipe called a "điếu cày" (English: "farmer's pipe") or a ceramic hookah called a "điếu bát". It may also occasionally be smoked in a more uncommon pipe known as a "điếu ống". The pipe is filled with an appropriate amount of water and a small amount of thuốc lào is pressed into the bowl.
One then ignites the tobacco and inhales to create a body of smoke inside the pipe, before exhaling the smoke, reversing the process of air in the pipe by blowing into it to pop out the tobacco. The smoker then sharply inhales, usually tilting the pipe upwards to an almost horizontal position (but not completely, as the water would drain out of the mouth).
Turkey.
"Maraş otu" (English: Maraş weed) is a chewing variant of "Nicotiana rustica" commonly used by people who live in Maraş, Turkey and other areas of the country. Maraş Otu is a mix of Oak tree ash and "Nicotiana rustica" that resembles henna. They use this by putting the mixture under their lips like Swedish "snus" or Afghan "naswar". It is recognized as a drug by anti-drug activists. It can contribute to mouth cancers.