8-Aminoquinoline

8-Aminoquinoline is the 8-amino derivative of quinoline. It is structurally analogous to 8-hydroxyquinoline. The two nitrogen atoms are ideally situated to form complexes with metal ions. Derivatives of 8-aminoquinoline are effective directing groups in organic synthesis.
Derivatives.
The derivatives primaquine, tafenoquine and pamaquine have been tested for anti-malaria activity. Primaquine is still used routinely worldwide as part of the treatment of "Plasmodium vivax" and "Plasmodium ovale" malaria. Tafenoquine was approved for medical use in Australia and in the United States in 2018.