Grecs du roi

Les grecs du roi are a celebrated Greek typeface designed by Claude Garamond in 1541 and containing a very large number of ligatures.
The "grecs du roi" were ordered by Robert Estienne on behalf of King Francis I of France. The design was based on the handwriting of the Cretan copyist Angelo Vergecio, and include a vast variety of alternate letters and ligatures to achieve this. Arthur Tilley calls the resulting books "among the most finished specimens of typography that exist".
The "grecs du roi" design placed significant demands on printers, since it requires a choice among the many possible types for every word, in contrast to Latin-alphabet general-purpose typefaces which do not attempt to simulate handwriting as closely. Most following typefaces for Greek have been much simpler. Gerry Leonidas, a leading expert on Greek typesetting, has commented that Vergecio's handwriting "has all the marks of a script that is unsuitable for conversion to [printing]. That it was the model for the widely-copied "grecs-du-roi" was, with hindsight, unfortunate."
Digitization.
Digital versions of the Grecs du roi are available.
A commercial OpenType font from Anagrafi Fonts, "KS GrequeX", includes over 1100 glyphs and ligatures. 
There is a free digital font, "Grecs du roi WG", without any ligatures.